Cardiovascular System



Mission statement

We develop MR biomarkers to give new insights into metabolic, physiological and functional alterations in cardiovascular diseases. Our work aims at improving prognosis, diagnosis and therapeutic follow up. We target pathologies leading to diffuse alterations of heart and blood vessels (diabetes and obesity, heart transplantation, dilated cardiomyopathy).

Development of original methods focuses on arterial spin labeling (ASL) perfusion MRI, advanced sampling and reconstruction strategies, flow imaging, sodium MRI and proton and phosphorus spectroscopy. We propose a comprehensive and transversal characterization of the cardiovascular system scaling from isolated perfused rodent heart model to in vivo rodent models and human studies. Thus, a wide range of MR modalities is exploited to cover each scientific domain with dedicated methodology.

The team is inherently multidisciplinary with expertise in biochemistry and physics as well as in various medical disciplines: namely cardiology, radiology and vascular surgery.


Research Topics


Publications

Silva-Verissimo, W., F. El Louali, Y. Godio-Raboutet, Lugdivine Leblond, Joevin Sourdon, S. Rapacchi, and Morgane Evin. “Traction Mechanical Characterization of Porcine Mitral Valve Annulus.” Journal of Biomechanics 146 (November 20, 2022): 111396. https://doi.org/10.1016/j.jbiomech.2022.111396.
Barral, Pierre-Antoine, Mariangela De Masi, Axel Bartoli, Paul Beunon, Arnaud Gallon, Farouk Tradi, Jean-François Hak, Marine Gaudry, and Alexis Jacquier. “Angio Cone-Beam CT (Angio-CBCT) and 3D Road-Mapping for the Detection of Spinal Cord Vascularization in Patients Requiring Treatment for a Thoracic Aortic Lesion: A Feasibility Study.” Journal of Personalized Medicine 12, no. 11 (November 11, 2022): 1890. https://doi.org/10.3390/jpm12111890.
Alqahtani, Mubarak, Amandine Claudinot, Marine Gaudry, Axel Bartoli, Pierre Antoine Barral, Vincent Vidal, Louis Boyer, et al. “Endovascular Management of Vascular Complications in Ehlers-Danlos Syndrome Type IV.” Journal of Clinical Medicine 11, no. 21 (October 27, 2022): 6344. https://doi.org/10.3390/jcm11216344.
Gaudry, Marine, Carine Guivier-Curien, Arnaud Blanchard, Alizée Porto, Laurence Bal, Virgile Omnes, Mariangela De Masi, et al. “Volume Analysis to Predict the Long-Term Evolution of Residual Aortic Dissection after Type A Repair.” Journal of Cardiovascular Development and Disease 9, no. 10 (October 12, 2022): 349. https://doi.org/10.3390/jcdd9100349.
Bernard, Monique. “Editorial for ‘Differential Adaptation of Biventricular Myocardial Kinetic Energy in Patients with Repaired Tetralogy of Fallot Assessed by MR Tissue Phase Mapping.’” Journal of Magnetic Resonance Imaging: JMRI, September 13, 2022. https://doi.org/10.1002/jmri.28417.
Lezoualc’h, F., L. Badimon, H. Baker, M. Bernard, G. Czibik, R. A. de Boer, T. D’Humières, et al. “The Need for Adjusting Experimental Models to Meet Clinical Reality.” Cardiovascular Research, September 9, 2022, cvac152. https://doi.org/10.1093/cvr/cvac152.
Calcagno, Claudia, John A. David, Abdallah G. Motaal, Bram F. Coolen, Thijs Beldman, Alexandra Corbin, Arnav Kak, et al. “Self-Gated, Dynamic Contrast-Enhanced Magnetic Resonance Imaging with Compressed-Sensing Reconstruction for Evaluating Endothelial Permeability in the Aortic Root of Atherosclerotic Mice.” NMR in Biomedicine, August 28, 2022, e4823. https://doi.org/10.1002/nbm.4823.
Rapacchi, Stanislas, Magalie Viallon, and Pierre Croisille. “Editorial for ‘Impact of Temporal Resolution and Methods for Correction on Cardiovascular Magnetic Resonance Perfusion Quantification.’” Journal of Magnetic Resonance Imaging: JMRI, August 22, 2022. https://doi.org/10.1002/jmri.28402.
Quiclet, Charline, Martine Armand, Hervé Dubouchaud, Guillaume Vial, Eric Fontaine, Cécile Batandier, and Karine Couturier. “Maternal Training during Lactation Modifies Breast Milk Fatty Acid Composition and Male Offspring Glucose Homeostasis in Rat.” Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids, August 17, 2022, 159223. https://doi.org/10.1016/j.bbalip.2022.159223.
Kober, Frank, Astrid Soghomonian, and Anne Dutour. “Editorial for ‘Effect of Obesity on Left Ventricular Remodeling and Clinical Outcome in Chinese Patients With Hypertrophic Cardiomyopathy Assessed by Cardiac Magnetic Resonance Imaging.’” Journal of Magnetic Resonance Imaging: JMRI, July 8, 2022. https://doi.org/10.1002/jmri.28339.
Lutz, Norbert W., and Monique Bernard. “Methodological Developments for Metabolic NMR Spectroscopy from Cultured Cells to Tissue Extracts: Achievements, Progress and Pitfalls.” Molecules (Basel, Switzerland) 27, no. 13 (June 30, 2022): 4214. https://doi.org/10.3390/molecules27134214.
Cadour, Farah, Jennifer Cautela, Stanislas Rapacchi, Arthur Varoquaux, Paul Habert, François Arnaud, Alexis Jacquier, et al. “Cardiac MRI Features and Prognostic Value in Immune Checkpoint                    Inhibitor–Induced Myocarditis.” Radiology 303, no. 3 (June 2022): 512–21. https://doi.org/10.1148/radiol.211765.
Quast, Christine, Frank Kober, Katrin Becker, Elric Zweck, Jasmina Hoffe, Christoph Jacoby, Vera Flocke, et al. “Multiparametric MRI Identifies Subtle Adaptations for Demarcation of Disease Transition in Murine Aortic Valve Stenosis.” Basic Research in Cardiology 117, no. 1 (May 29, 2022): 29. https://doi.org/10.1007/s00395-022-00936-5.
Hoesl, Michaela A. U., Lothar R. Schad, and Stanislas Rapacchi. “Volumetric 23Na Single and Triple-Quantum Imaging at 7T: 3D-CRISTINA.” Zeitschrift Für Medizinische Physik 32, no. 2 (May 1, 2022): 199–208. https://doi.org/10.1016/j.zemedi.2021.09.001.
Yuan, Wen Lun, Jonathan Y. Bernard, Martine Armand, Catherine Sarté, Marie Aline Charles, and Barbara Heude. “Associations of Maternal Consumption of Dairy Products during Pregnancy with Perinatal Fatty Acids Profile in the EDEN Cohort Study.” Nutrients 14, no. 8 (April 14, 2022): 1636. https://doi.org/10.3390/nu14081636.
Garbi, Aurélie, Martine Armand, Any-Alejand Beltran-Anzola, Catherine Sarté, Véronique Brévaut-Malaty, Barthélémy Tosello, and Catherine Gire. “Effect of Massage with Oil Balanced in Essential Fatty Acids on Development and Lipid Parameters in Very Premature Neonates: A Randomized, Controlled Study.” Children 9, no. 4 (March 25, 2022): 463. https://doi.org/10.3390/children9040463.
Xerri, Alexandre, Frédéric Gallardo, Frank Kober, Calypso Mathieu, Natacha Fourny, Thi Thom Tran, Jean-Louis Mege, et al. “Female Hormones Prevent Sepsis-Induced Cardiac Dysfunction: An Experimental Randomized Study.” Scientific Reports 12, no. 1 (March 23, 2022): 4939. https://doi.org/10.1038/s41598-022-08889-4.
Bernard, Monique. “Editorial for ‘Prospective Evaluation of Virtual MR Elastography With Diffusion Weighted Imaging in Subjects With Nonalcoholic Fatty Liver Disease.’” Journal of Magnetic Resonance Imaging: JMRI, March 15, 2022. https://doi.org/10.1002/jmri.28155.
Cadour, Farah, François Silhol, Nicolas Iline, Roch Giorgi, Aurélien Lorthioir, Laurence Amar, Marc Sapoval, et al. “Insights from Intravascular Pressure Measurement of Renal Artery Revascularization in Patients with Fibromuscular Dysplasia: The DYSART Study.” Journal of Vascular Surgery 75, no. 3 (March 1, 2022): 939-949.e1. https://doi.org/10.1016/j.jvs.2021.09.023.
Pirocca, Ugo, Nawale Hadouiri, Axel Bartoli, Thibaud Morcet-Delattre, François Pontana, Hubert Cochet, Vania Tacher, Farah Cadour, Damien Mandry, and Alexis Jacquier. “How Attractive Is Cardiac Imaging to French Radiology Residents?” Diagnostic and Interventional Imaging 103, no. 3 (March 2022): 185–88. https://doi.org/10.1016/j.diii.2021.12.004.
Vergara Gomez, Tania S., Marc Dubois, Kaizad Rustomji, Elodie Georget, Tryfon Antonakakis, Alexandre Vignaud, Stanislas Rapacchi, et al. “Hilbert Fractal Inspired Dipoles for Passive RF Shimming in Ultra-High Field MRI.” Photonics and Nanostructures - Fundamentals and Applications 48 (February 1, 2022): 100988. https://doi.org/10.1016/j.photonics.2021.100988.
Jourdan, Arthur, Stanislas Rapacchi, Maxime Guye, David Bendahan, Catherine Masson, and Thierry Bège. “Dynamic-MRI Quantification of Abdominal Wall Motion and Deformation during Breathing and Muscular Contraction.” Computer Methods and Programs in Biomedicine 217 (January 29, 2022): 106667. https://doi.org/10.1016/j.cmpb.2022.106667.
Daudé, Pierre, Patricia Ancel, Sylviane Confort Gouny, Alexis Jacquier, Frank Kober, Anne Dutour, Monique Bernard, Bénédicte Gaborit, and Stanislas Rapacchi. “Deep-Learning Segmentation of Epicardial Adipose Tissue Using Four-Chamber Cardiac Magnetic Resonance Imaging.” Diagnostics (Basel, Switzerland) 12, no. 1 (January 6, 2022): 126. https://doi.org/10.3390/diagnostics12010126.
Bartoli, Axel, Joris Fournel, Léa Ait-Yahia, Farah Cadour, Farouk Tradi, Badih Ghattas, Sébastien Cortaredona, et al. “Automatic Deep-Learning Segmentation of Epicardial Adipose Tissue from Low-Dose Chest CT and Prognosis Impact on COVID-19.” Cells 11, no. 6 (January 2022): 1034. https://doi.org/10.3390/cells11061034.
Cadour, Farah, Franck Thuny, and Joevin Sourdon. “New Insights in Early Detection of Anticancer Drug-Related Cardiotoxicity Using Perfusion and Metabolic Imaging.” Frontiers in Cardiovascular Medicine 9 (2022): 813883. https://doi.org/10.3389/fcvm.2022.813883.
Boussuges, Alain, Paul Habert, Guillaume Chaumet, Rawah Rouibah, Lea Delorme, Amelie Menard, Matthieu Million, et al. “Diaphragm Dysfunction after Severe COVID-19: An Ultrasound Study.” Frontiers in Medicine 9 (2022): 949281. https://doi.org/10.3389/fmed.2022.949281.
Kober, Frank, and Monique Bernard. “Cardiac In Vivo Magnetic Resonance Spectroscopy.” In Encyclopedia of Biophysics, edited by Gordon Roberts and Anthony Watts, 1–4. Berlin, Heidelberg: Springer, 2022. https://doi.org/10.1007/978-3-642-35943-9_10103-1.
Brui, Ekaterina A., Stanislas Rapacchi, David Bendahan, and Anna E. Andreychenko. “Comparative Analysis of SINC-Shaped and SLR Pulses Performance for Contiguous Multi-Slice Fast Spin-Echo Imaging Using Metamaterial-Based MRI.” Magnetic Resonance Materials in Physics, Biology and Medicine 34, no. 6 (December 1, 2021): 929–38. https://doi.org/10.1007/s10334-021-00937-w.
Dudouet, Pierre, Serge Cammilleri, Eric Guedj, Alexis Jacquier, Didier Raoult, and Carole Eldin. “Aortic 18F-FDG PET/CT Hypermetabolism in Patients with Long COVID: A Retrospective Study.” Clinical Microbiology and Infection 27, no. 12 (December 1, 2021): 1873–75. https://doi.org/10.1016/j.cmi.2021.09.020.
Volff, Maxime, David Tonon, Youri Bommel, Noémie Peres, David Lagier, Geoffray Agard, Alexis Jacquier, et al. “Factors Associated with 90-Day Mortality in Invasively Ventilated Patients with COVID-19 in Marseille, France.” Journal of Clinical Medicine 10, no. 23 (November 30, 2021): 5650. https://doi.org/10.3390/jcm10235650.
Tacher, Vania, Islem Sifaoui, Rym Kharrat, Jean-Nicolas Dacher, Virgile Chevance, Romain Gallet, Emmanuel Teiger, et al. “The Use of Cardiac Computed Tomography Angiography in the Assessment of Percutaneous Left Atrial Appendage Closure – Review and Experts Recommendations Endorsed by the Société Française d’imagerie Cardiaque et Vasculaire Diagnostique et Interventionnelle.” Diagnostic and Interventional Imaging 102, no. 10 (October 1, 2021): 586–92. https://doi.org/10.1016/j.diii.2021.05.010.
Hostalrich, Aurélien, Thomas Mesnard, Raphael Soler, Paul Girardet, Adrien Kaladji, Elixéne Jean Baptiste, Serguei Malikov, et al. “Prospective Multicentre Cohort Study of Fenestrated and Branched Endografts After Failed Endovascular Infrarenal Aortic Aneurysm Repair with Type Ia Endoleak.” European Journal of Vascular and Endovascular Surgery: The Official Journal of the European Society for Vascular Surgery 62, no. 4 (October 2021): 540–48. https://doi.org/10.1016/j.ejvs.2021.06.019.
Préau, Yannis, Sébastien Galie, Pauline Schaepelynck, Martine Armand, and Denis Raccah. “Benefits of a Switch from Intermittently Scanned Continuous Glucose Monitoring (IsCGM) to Real-Time (Rt) CGM in Diabetes Type 1 Suboptimal Controlled Patients in Real-Life: A One-Year Prospective Study §.” Sensors (Basel, Switzerland) 21, no. 18 (September 13, 2021): 6131. https://doi.org/10.3390/s21186131.
Fourny, Natacha, Carole Lan, Monique Bernard, and Martine Desrois. “Male and Female Rats Have Different Physiological Response to High-Fat High-Sucrose Diet but Similar Myocardial Sensitivity to Ischemia-Reperfusion Injury.” Nutrients 13, no. 9 (August 24, 2021): 2914. https://doi.org/10.3390/nu13092914.
Fournel, Joris, Axel Bartoli, David Bendahan, Maxime Guye, Monique Bernard, Elisa Rauseo, Mohammed Y. Khanji, Steffen E. Petersen, Alexis Jacquier, and Badih Ghattas. “Medical Image Segmentation Automatic Quality Control: A Multi-Dimensional Approach.” Medical Image Analysis 74 (August 12, 2021): 102213. https://doi.org/10.1016/j.media.2021.102213.
Barral, Pierre-Antoine, Alexis Jacquier, Virgile Omnes, Philippe Piquet, and Marine Gaudry. “Type B Aortic Dissection Treated With a Branched Aortic Arch Stent Graft and the STABILISE Technique.” Annals of Vascular Surgery 75 (August 2021): 531.e19-531.e22. https://doi.org/10.1016/j.avsg.2021.03.028.
Préau, Yannis, Martine Armand, Sébastien Galie, Pauline Schaepelynck, and Denis Raccah. “Reply to Letter by Alexander Seibold on ‘Impact of Switching from Intermittently Scanned to Real-Time Continuous Glucose Monitoring Systems in a Type 1 Diabetes Patient French Cohort: An Observational Study of Clinical Practices’ by Yannis Préau, et al. (Doi: 10.1089/Dia.2020.0674).” Diabetes Technology & Therapeutics 23, no. 8 (August 2021): 598–600. https://doi.org/10.1089/dia.2021.0087.
Soler, Raphael, Michel A. Bartoli, Philippe Amabile, Gabrielle Sarlon-Bartoli, and Pierre-Édouard Magnan. “STABILISE for Complicated Type B Dissection after 15 Months’ Follow Up: A Word of Caution.” European Journal of Vascular and Endovascular Surgery: The Official Journal of the European Society for Vascular Surgery 62, no. 1 (July 2021): 138–39. https://doi.org/10.1016/j.ejvs.2021.02.025.
Le Ven, Florent, François Pontana, Gilles Barone-Rochette, Laurent Macron, Jérome Garot, Olivier Genée, Damien Mandry, et al. “Position Paper on Stress Cardiac MRI in Chronic Coronary Syndrome: Endorsed by the Société Française de Radiologie (SFR) the Société Française d’Imagerie CardioVasculaire (SFICV) and the Société Française de Cardiologie (SFC).” Diagnostic and Interventional Imaging 102, no. 6 (June 2021): 337–45. https://doi.org/10.1016/j.diii.2021.02.005.
Gaudry, Marine, Pierre-Antoine Barral, Arnaud Blanchard, Sylvie Palazzolo, Sonia Bolomey, Virgile Omnes, Mariangela De Masi, et al. “Prevalence of Thoracic Aortic Aneurysms in Patients with Degenerative Abdominal Aortic Aneurysms: Results from the Prospective ACTA Study.” European Journal of Vascular and Endovascular Surgery: The Official Journal of the European Society for Vascular Surgery 61, no. 6 (June 2021): 930–37. https://doi.org/10.1016/j.ejvs.2021.03.004.
Ku, Min-Chi, Frank Kober, Yi-Ching Lai, Andreas Pohlmann, Fatimunnisa Qadri, Michael Bader, Lucie Carrier, and Thoralf Niendorf. “Cardiovascular Magnetic Resonance Detects Microvascular Dysfunction in a Mouse Model of Hypertrophic Cardiomyopathy.” Journal of Cardiovascular Magnetic Resonance: Official Journal of the Society for Cardiovascular Magnetic Resonance 23, no. 1 (May 31, 2021): 63. https://doi.org/10.1186/s12968-021-00754-z.
Finance, Julie, Laurent Zieleskewicz, Paul Habert, Alexis Jacquier, Philippe Parola, Alain Boussuges, Fabienne Bregeon, and Carole Eldin. “Low Dose Chest CT and Lung Ultrasound for the Diagnosis and Management of COVID-19.” Journal of Clinical Medicine 10, no. 10 (May 19, 2021): 2196. https://doi.org/10.3390/jcm10102196.
Sourdon, Joevin, Tangi Roussel, Claire Costes, Patrick Viout, Maxime Guye, Jean-Philippe Ranjeva, Monique Bernard, Frank Kober, and Stanislas Rapacchi. “Comparison of Single-Voxel 1H-Cardiovascular Magnetic Resonance Spectroscopy Techniques for in Vivo Measurement of Myocardial Creatine and Triglycerides at 3T.” Journal of Cardiovascular Magnetic Resonance: Official Journal of the Society for Cardiovascular Magnetic Resonance 23, no. 1 (May 13, 2021): 53. https://doi.org/10.1186/s12968-021-00748-x.
Préau, Yannis, Martine Armand, Sébastien Galie, Pauline Schaepelynck, and Denis Raccah. “Impact of Switching from Intermittently Scanned to Real-Time Continuous Glucose Monitoring Systems in a Type 1 Diabetes Patient French Cohort: An Observational Study of Clinical Practices.” Diabetes Technology & Therapeutics 23, no. 4 (April 2021): 259–67. https://doi.org/10.1089/dia.2020.0515.
Le Ven, Florent, Jean-Nicolas Dacher, François Pontana, Gilles Barone-Rochette, Laurent Macron, Jerome Garot, Olivier Genée, et al. “Position Paper on Stress Cardiac Magnetic Resonance Imaging in Chronic Coronary Syndrome: Endorsed by the Société Française de Radiologie (SFR), the Société Française d’imagerie Cardiovasculaire (SFICV) and the Société Française de Cardiologie (SFC).” Archives of Cardiovascular Diseases 114, no. 4 (April 2021): 325–35. https://doi.org/10.1016/j.acvd.2021.02.004.
Sarlon-Bartoli, G., Q. Michel, E. Sarlon, M. Carcopino-Tusoli, P. Suchon, R. Soler, M. A. Bartoli, D. Brunet, P. Morange, and A. Charbonnier. “Ultrasound Arterial Anomalies in Patients Exposed to Nilotinib Therapy for Chronic Myeloid Leukemia.” Journal De Medecine Vasculaire 46, no. 2 (April 2021): 66–71. https://doi.org/10.1016/j.jdmv.2021.02.002.
Gaborit, B., P. Ancel, A. E. Abdullah, F. Maurice, I. Abdesselam, A. Calen, A. Soghomonian, et al. “Effect of Empagliflozin on Ectopic Fat Stores and Myocardial Energetics in Type 2 Diabetes: The EMPACEF Study.” Cardiovascular Diabetology 20, no. 1 (March 1, 2021): 57. https://doi.org/10.1186/s12933-021-01237-2.
Kober, Frank. “Editorial for ‘Clinical Quantification of Myocardial Perfusion With Vasodilation Using Arterial Spin Labeling at 1.5T.’” Journal of Magnetic Resonance Imaging: JMRI 53, no. 3 (March 2021): 789–90. https://doi.org/10.1002/jmri.27422.
Rossem, Lenie van, Henriette A. Smit, Martine Armand, Jonathan Y. Bernard, Hans Bisgaard, Klaus Bønnelykke, Signe Bruun, et al. “Breast Milk N-3 Long-Chain Polyunsaturated Fatty Acids and Blood Pressure: An Individual Participant Meta-Analysis.” European Journal of Nutrition 60, no. 2 (March 2021): 989–98. https://doi.org/10.1007/s00394-020-02310-4.
Foussier, C., P. A. Barral, M. Jerosh-Herold, V. Gariboldi, S. Rapacchi, A. Gallon, A. Bartoli, et al. “Quantification of Diffuse Myocardial Fibrosis Using CMR Extracellular Volume Fraction and Serum Biomarkers of Collagen Turnover with Histologic Quantification as Standard of Reference.” Diagnostic and Interventional Imaging 102, no. 3 (March 2021): 163–69. https://doi.org/10.1016/j.diii.2020.07.005.