Cardiovascular System



Mission statement

We develop MR biomarkers to give new insights into metabolic, physiological and functional alterations in cardiovascular diseases. Our work aims at improving prognosis, diagnosis and therapeutic follow up. We target pathologies leading to diffuse alterations of heart and blood vessels (diabetes and obesity, heart transplantation, dilated cardiomyopathy).

Development of original methods focuses on arterial spin labeling (ASL) perfusion MRI, advanced sampling and reconstruction strategies, flow imaging, sodium MRI and proton and phosphorus spectroscopy. We propose a comprehensive and transversal characterization of the cardiovascular system scaling from isolated perfused rodent heart model to in vivo rodent models and human studies. Thus, a wide range of MR modalities is exploited to cover each scientific domain with dedicated methodology.

The team is inherently multidisciplinary with expertise in biochemistry and physics as well as in various medical disciplines: namely cardiology, radiology and vascular surgery.


Research Topics


Publications

Yuan, Wen Lun, Jonathan Y. Bernard, Martine Armand, Catherine Sarté, Marie Aline Charles, and Barbara Heude. “Associations of Maternal Consumption of Dairy Products during Pregnancy with Perinatal Fatty Acids Profile in the EDEN Cohort Study.” Nutrients 14, no. 8 (April 14, 2022): 1636. https://doi.org/10.3390/nu14081636.
Garbi, Aurélie, Martine Armand, Any-Alejand Beltran-Anzola, Catherine Sarté, Véronique Brévaut-Malaty, Barthélémy Tosello, and Catherine Gire. “Effect of Massage with Oil Balanced in Essential Fatty Acids on Development and Lipid Parameters in Very Premature Neonates: A Randomized, Controlled Study.” Children 9, no. 4 (March 25, 2022): 463. https://doi.org/10.3390/children9040463.
Xerri, Alexandre, Frédéric Gallardo, Frank Kober, Calypso Mathieu, Natacha Fourny, Thi Thom Tran, Jean-Louis Mege, et al. “Female Hormones Prevent Sepsis-Induced Cardiac Dysfunction: An Experimental Randomized Study.” Scientific Reports 12, no. 1 (March 23, 2022): 4939. https://doi.org/10.1038/s41598-022-08889-4.
Bernard, Monique. “Editorial for ‘Prospective Evaluation of Virtual MR Elastography With Diffusion Weighted Imaging in Subjects With Nonalcoholic Fatty Liver Disease.’” Journal of Magnetic Resonance Imaging: JMRI, March 15, 2022. https://doi.org/10.1002/jmri.28155.
Cadour, Farah, Jennifer Cautela, Stanislas Rapacchi, Arthur Varoquaux, Paul Habert, François Arnaud, Alexis Jacquier, et al. “Cardiac MRI Features and Prognostic Value in Immune Checkpoint Inhibitor-Induced Myocarditis.” Radiology, March 1, 2022, 211765. https://doi.org/10.1148/radiol.211765.
Vergara Gomez, Tania S., Marc Dubois, Kaizad Rustomji, Elodie Georget, Tryfon Antonakakis, Alexandre Vignaud, Stanislas Rapacchi, et al. “Hilbert Fractal Inspired Dipoles for Passive RF Shimming in Ultra-High Field MRI.” Photonics and Nanostructures - Fundamentals and Applications 48 (February 1, 2022): 100988. https://doi.org/10.1016/j.photonics.2021.100988.
Jourdan, Arthur, Stanislas Rapacchi, Maxime Guye, David Bendahan, Catherine Masson, and Thierry Bège. “Dynamic-MRI Quantification of Abdominal Wall Motion and Deformation during Breathing and Muscular Contraction.” Computer Methods and Programs in Biomedicine 217 (January 29, 2022): 106667. https://doi.org/10.1016/j.cmpb.2022.106667.
Daudé, Pierre, Patricia Ancel, Sylviane Confort Gouny, Alexis Jacquier, Frank Kober, Anne Dutour, Monique Bernard, Bénédicte Gaborit, and Stanislas Rapacchi. “Deep-Learning Segmentation of Epicardial Adipose Tissue Using Four-Chamber Cardiac Magnetic Resonance Imaging.” Diagnostics (Basel, Switzerland) 12, no. 1 (January 6, 2022): 126. https://doi.org/10.3390/diagnostics12010126.
Bartoli, Axel, Joris Fournel, Léa Ait-Yahia, Farah Cadour, Farouk Tradi, Badih Ghattas, Sébastien Cortaredona, et al. “Automatic Deep-Learning Segmentation of Epicardial Adipose Tissue from Low-Dose Chest CT and Prognosis Impact on COVID-19.” Cells 11, no. 6 (January 2022): 1034. https://doi.org/10.3390/cells11061034.
Volff, Maxime, David Tonon, Youri Bommel, Noémie Peres, David Lagier, Geoffray Agard, Alexis Jacquier, et al. “Factors Associated with 90-Day Mortality in Invasively Ventilated Patients with COVID-19 in Marseille, France.” Journal of Clinical Medicine 10, no. 23 (November 30, 2021): 5650. https://doi.org/10.3390/jcm10235650.
Hoesl, Michaela A. U., Lothar R. Schad, and Stanislas Rapacchi. “Volumetric 23Na Single and Triple-Quantum Imaging at 7T: 3D-CRISTINA.” Zeitschrift Fur Medizinische Physik, October 26, 2021, S0939-3889(21)00083-0. https://doi.org/10.1016/j.zemedi.2021.09.001.
Cadour, Farah, François Silhol, Nicolas Iline, Roch Giorgi, Aurélien Lorthioir, Laurence Amar, Marc Sapoval, et al. “Insights from Intravascular Pressure Measurement of Renal Artery Revascularization in Patients with Fibromuscular Dysplasia: The DYSART Study.” Journal of Vascular Surgery, September 30, 2021, S0741-5214(21)02180-7. https://doi.org/10.1016/j.jvs.2021.09.023.
Dudouet, Pierre, Serge Cammilleri, Eric Guedj, Alexis Jacquier, Didier Raoult, and Carole Eldin. “Aortic [18F] FDG-PET/CT Hypermetabolism in Patients with Long COVID: A Retrospective Study.” Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases, September 27, 2021, S1198-743X(21)00542-5. https://doi.org/10.1016/j.cmi.2021.09.020.
Préau, Yannis, Sébastien Galie, Pauline Schaepelynck, Martine Armand, and Denis Raccah. “Benefits of a Switch from Intermittently Scanned Continuous Glucose Monitoring (IsCGM) to Real-Time (Rt) CGM in Diabetes Type 1 Suboptimal Controlled Patients in Real-Life: A One-Year Prospective Study §.” Sensors (Basel, Switzerland) 21, no. 18 (September 13, 2021): 6131. https://doi.org/10.3390/s21186131.
Fourny, Natacha, Carole Lan, Monique Bernard, and Martine Desrois. “Male and Female Rats Have Different Physiological Response to High-Fat High-Sucrose Diet but Similar Myocardial Sensitivity to Ischemia-Reperfusion Injury.” Nutrients 13, no. 9 (August 24, 2021): 2914. https://doi.org/10.3390/nu13092914.
Fournel, Joris, Axel Bartoli, David Bendahan, Maxime Guye, Monique Bernard, Elisa Rauseo, Mohammed Y. Khanji, Steffen E. Petersen, Alexis Jacquier, and Badih Ghattas. “Medical Image Segmentation Automatic Quality Control: A Multi-Dimensional Approach.” Medical Image Analysis 74 (August 12, 2021): 102213. https://doi.org/10.1016/j.media.2021.102213.
Préau, Yannis, Martine Armand, Sébastien Galie, Pauline Schaepelynck, and Denis Raccah. “Reply to Letter by Alexander Seibold on ‘Impact of Switching from Intermittently Scanned to Real-Time Continuous Glucose Monitoring Systems in a Type 1 Diabetes Patient French Cohort: An Observational Study of Clinical Practices’ by Yannis Préau, et al. (Doi: 10.1089/Dia.2020.0674).” Diabetes Technology & Therapeutics 23, no. 8 (August 2021): 598–600. https://doi.org/10.1089/dia.2021.0087.
Barral, Pierre-Antoine, Alexis Jacquier, Virgile Omnes, Philippe Piquet, and Marine Gaudry. “Type B Aortic Dissection Treated With a Branched Aortic Arch Stent Graft and the STABILISE Technique.” Annals of Vascular Surgery 75 (August 2021): 531.e19-531.e22. https://doi.org/10.1016/j.avsg.2021.03.028.
Soler, Raphael, Michel A. Bartoli, Philippe Amabile, Gabrielle Sarlon-Bartoli, and Pierre-Édouard Magnan. “STABILISE for Complicated Type B Dissection after 15 Months’ Follow Up: A Word of Caution.” European Journal of Vascular and Endovascular Surgery: The Official Journal of the European Society for Vascular Surgery 62, no. 1 (July 2021): 138–39. https://doi.org/10.1016/j.ejvs.2021.02.025.
Brui, Ekaterina A., Stanislas Rapacchi, David Bendahan, and Anna E. Andreychenko. “Comparative Analysis of SINC-Shaped and SLR Pulses Performance for Contiguous Multi-Slice Fast Spin-Echo Imaging Using Metamaterial-Based MRI.” Magma (New York, N.Y.), June 28, 2021. https://doi.org/10.1007/s10334-021-00937-w.
Tacher, Vania, Islem Sifaoui, Rym Kharrat, Jean-Nicolas Dacher, Virgile Chevance, Romain Gallet, Emmanuel Teiger, et al. “The Use of Cardiac Computed Tomography Angiography in the Assessment of Percutaneous Left Atrial Appendage Closure - Review and Experts Recommendations Endorsed by the Société Française d’imagerie Cardiaque et Vasculaire Diagnostique et Interventionnelle.” Diagnostic and Interventional Imaging, June 16, 2021, S2211-5684(21)00140-6. https://doi.org/10.1016/j.diii.2021.05.010.
Gaudry, Marine, Pierre-Antoine Barral, Arnaud Blanchard, Sylvie Palazzolo, Sonia Bolomey, Virgile Omnes, Mariangela De Masi, et al. “Prevalence of Thoracic Aortic Aneurysms in Patients with Degenerative Abdominal Aortic Aneurysms: Results from the Prospective ACTA Study.” European Journal of Vascular and Endovascular Surgery: The Official Journal of the European Society for Vascular Surgery 61, no. 6 (June 2021): 930–37. https://doi.org/10.1016/j.ejvs.2021.03.004.
Le Ven, Florent, François Pontana, Gilles Barone-Rochette, Laurent Macron, Jérome Garot, Olivier Genée, Damien Mandry, et al. “Position Paper on Stress Cardiac MRI in Chronic Coronary Syndrome: Endorsed by the Société Française de Radiologie (SFR) the Société Française d’Imagerie CardioVasculaire (SFICV) and the Société Française de Cardiologie (SFC).” Diagnostic and Interventional Imaging 102, no. 6 (June 2021): 337–45. https://doi.org/10.1016/j.diii.2021.02.005.
Ku, Min-Chi, Frank Kober, Yi-Ching Lai, Andreas Pohlmann, Fatimunnisa Qadri, Michael Bader, Lucie Carrier, and Thoralf Niendorf. “Cardiovascular Magnetic Resonance Detects Microvascular Dysfunction in a Mouse Model of Hypertrophic Cardiomyopathy.” Journal of Cardiovascular Magnetic Resonance: Official Journal of the Society for Cardiovascular Magnetic Resonance 23, no. 1 (May 31, 2021): 63. https://doi.org/10.1186/s12968-021-00754-z.
Rapacchi, Stanislas, and Bénédicte Gaborit. “Editorial for ‘Association of Type 2 Diabetes Mellitus and Glycemic Control With Intracranial Plaque Characteristics in Patients With Acute Ischemic Stroke.’” Journal of Magnetic Resonance Imaging: JMRI, May 27, 2021. https://doi.org/10.1002/jmri.27739.
Finance, Julie, Laurent Zieleskewicz, Paul Habert, Alexis Jacquier, Philippe Parola, Alain Boussuges, Fabienne Bregeon, and Carole Eldin. “Low Dose Chest CT and Lung Ultrasound for the Diagnosis and Management of COVID-19.” Journal of Clinical Medicine 10, no. 10 (May 19, 2021): 2196. https://doi.org/10.3390/jcm10102196.
Sourdon, Joevin, Tangi Roussel, Claire Costes, Patrick Viout, Maxime Guye, Jean-Philippe Ranjeva, Monique Bernard, Frank Kober, and Stanislas Rapacchi. “Comparison of Single-Voxel 1H-Cardiovascular Magnetic Resonance Spectroscopy Techniques for in Vivo Measurement of Myocardial Creatine and Triglycerides at 3T.” Journal of Cardiovascular Magnetic Resonance: Official Journal of the Society for Cardiovascular Magnetic Resonance 23, no. 1 (May 13, 2021): 53. https://doi.org/10.1186/s12968-021-00748-x.
Préau, Yannis, Martine Armand, Sébastien Galie, Pauline Schaepelynck, and Denis Raccah. “Impact of Switching from Intermittently Scanned to Real-Time Continuous Glucose Monitoring Systems in a Type 1 Diabetes Patient French Cohort: An Observational Study of Clinical Practices.” Diabetes Technology & Therapeutics 23, no. 4 (April 2021): 259–67. https://doi.org/10.1089/dia.2020.0515.
Le Ven, Florent, Jean-Nicolas Dacher, François Pontana, Gilles Barone-Rochette, Laurent Macron, Jerome Garot, Olivier Genée, et al. “Position Paper on Stress Cardiac Magnetic Resonance Imaging in Chronic Coronary Syndrome: Endorsed by the Société Française de Radiologie (SFR), the Société Française d’imagerie Cardiovasculaire (SFICV) and the Société Française de Cardiologie (SFC).” Archives of Cardiovascular Diseases 114, no. 4 (April 2021): 325–35. https://doi.org/10.1016/j.acvd.2021.02.004.
Sarlon-Bartoli, G., Q. Michel, E. Sarlon, M. Carcopino-Tusoli, P. Suchon, R. Soler, M. A. Bartoli, D. Brunet, P. Morange, and A. Charbonnier. “Ultrasound Arterial Anomalies in Patients Exposed to Nilotinib Therapy for Chronic Myeloid Leukemia.” Journal De Medecine Vasculaire 46, no. 2 (April 2021): 66–71. https://doi.org/10.1016/j.jdmv.2021.02.002.
Gaborit, B., P. Ancel, A. E. Abdullah, F. Maurice, I. Abdesselam, A. Calen, A. Soghomonian, et al. “Effect of Empagliflozin on Ectopic Fat Stores and Myocardial Energetics in Type 2 Diabetes: The EMPACEF Study.” Cardiovascular Diabetology 20, no. 1 (March 1, 2021): 57. https://doi.org/10.1186/s12933-021-01237-2.
Kober, Frank. “Editorial for ‘Clinical Quantification of Myocardial Perfusion With Vasodilation Using Arterial Spin Labeling at 1.5T.’” Journal of Magnetic Resonance Imaging: JMRI 53, no. 3 (March 2021): 789–90. https://doi.org/10.1002/jmri.27422.
Foussier, C., P. A. Barral, M. Jerosh-Herold, V. Gariboldi, S. Rapacchi, A. Gallon, A. Bartoli, et al. “Quantification of Diffuse Myocardial Fibrosis Using CMR Extracellular Volume Fraction and Serum Biomarkers of Collagen Turnover with Histologic Quantification as Standard of Reference.” Diagnostic and Interventional Imaging 102, no. 3 (March 2021): 163–69. https://doi.org/10.1016/j.diii.2020.07.005.
Rossem, Lenie van, Henriette A. Smit, Martine Armand, Jonathan Y. Bernard, Hans Bisgaard, Klaus Bønnelykke, Signe Bruun, et al. “Breast Milk N-3 Long-Chain Polyunsaturated Fatty Acids and Blood Pressure: An Individual Participant Meta-Analysis.” European Journal of Nutrition 60, no. 2 (March 2021): 989–98. https://doi.org/10.1007/s00394-020-02310-4.
Castelli, Maxime, Arnaud Maurin, Axel Bartoli, Michael Dassa, Baptiste Marchi, Julie Finance, Jean-Christophe Lagier, et al. “Correction to: Prevalence and Risk Factors for Lung Involvement on Low-Dose Chest CT (LDCT) in a Paucisymptomatic Population of 247 Patients Affected by COVID-19.” Insights into Imaging 12, no. 1 (February 16, 2021): 21. https://doi.org/10.1186/s13244-020-00950-y.
Jourdan, Arthur, Arnaud Le Troter, Pierre Daude, Stanislas Rapacchi, Catherine Masson, Thierry Bège, and David Bendahan. “Semiautomatic Quantification of Abdominal Wall Muscles Deformations Based on Dynamic MRI Image Registration.” NMR in Biomedicine, February 1, 2021, e4470. https://doi.org/10.1002/nbm.4470.
Habert, Paul, Mathieu Di Bisceglie, Axel Bartoli, Alexis Jacquier, Pauline Brige, Vincent Vidal, Jean-François Hak, Farouk Tradi, and Jean-Yves Gaubert. “Description of Morphological Evolution of Lung Tumors Treated by Percutaneous Radiofrequency Ablation: Long Term Follow-up of 100 Lesions with Chest CT.” International Journal of Hyperthermia 38, no. 1 (January 1, 2021): 786–94. https://doi.org/10.1080/02656736.2021.1928773.
Sourdon, Joevin, Sabra C. Lewsey, Michael Schär, and Robert G. Weiss. “Measuring Myocardial Energetics with Cardiovascular Magnetic Resonance Spectroscopy.” Heart Failure Clinics 17, no. 1 (January 2021): 149–56. https://doi.org/10.1016/j.hfc.2020.08.011.
Bartoli, Axel, Joris Fournel, Zakarya Bentatou, Gilbert Habib, Alain Lalande, Monique Bernard, Loïc Boussel, et al. “Deep Learning-Based Automated Segmentation of Left Ventricular Trabeculations and Myocardium on Cardiac MR Images: A Feasibility Study.” Radiology. Artificial Intelligence 3, no. 1 (January 2021): e200021. https://doi.org/10.1148/ryai.2020200021.
Soler, Raphael J., Michel A. Bartoli, Jeremy Bourenne, Alberto Riberi, David Lagier, Philippe Amabile, Gabrielle Sarlon-Bartoli, and Pierre-Edouard Magnan. “STABILISE Technique for a Non-A Non-B Acute Aortic Dissection in Marfan Syndrome.” Annals of Vascular Surgery 70 (January 2021): 569.e5-569.e10. https://doi.org/10.1016/j.avsg.2020.08.132.
Dhumal, Dinesh, Wenjun Lan, Ling Ding, Yifan Jiang, Zhenbin Lyu, Erik Laurini, Domenico Marson, et al. “An Ionizable Supramolecular Dendrimer Nanosystem for Effective SiRNA Delivery with a Favorable Safety Profile.” Nano Research 14, no. 7 (2021): 2247–54. https://doi.org/10.1007/s12274-020-3216-8.
Fourny, Natacha, Christophe Beauloye, Monique Bernard, Sandrine Horman, Martine Desrois, and Luc Bertrand. “Sex Differences of the Diabetic Heart.” Frontiers in Physiology 12 (2021): 661297. https://doi.org/10.3389/fphys.2021.661297.
Lasbleiz, Adèle, Bénédicte Gaborit, Astrid Soghomonian, Axel Bartoli, Patricia Ancel, Alexis Jacquier, and Anne Dutour. “COVID-19 and Obesity: Role of Ectopic Visceral and Epicardial Adipose Tissues in Myocardial Injury.” Frontiers in Endocrinology 12 (2021): 726967. https://doi.org/10.3389/fendo.2021.726967.
McGinnity, Colm J., Daniela A. Riaño Barros, Eric Guedj, Nadine Girard, Christopher Symeon, Helen Walker, Sally F. Barrington, Mary Summers, Mervi Pitkanen, and Yusof Rahman. “A Retrospective Case Series Analysis of the Relationship Between Phenylalanine: Tyrosine Ratio and Cerebral Glucose Metabolism in Classical Phenylketonuria and Hyperphenylalaninemia.” Frontiers in Neuroscience 15 (2021): 664525. https://doi.org/10.3389/fnins.2021.664525.
Chuang, Kai-Hsiang, Frank Kober, and Min-Chi Ku. “Quantitative Analysis of Renal Perfusion by Arterial Spin Labeling.” In Preclinical MRI of the Kidney, 2216:655–66. Methods in Molecular Biology. New York, NY: Humana, 2021. https://doi.org/10.1007/978-1-0716-0978-1_39.
Chuang, Kai-Hsiang, Martin Meier, María A. Fernández-Seara, Frank Kober, and Min-Chi Ku. “Renal Blood Flow Using Arterial Spin Labeling (ASL) MRI: Experimental Protocol and Principles.” In Preclinical MRI of the Kidney, 2216:443–53. Methods in Molecular Biology. New York, NY: Humana, 2021. https://doi.org/10.1007/978-1-0716-0978-1_26.
Ku, Min-Chi, María A. Fernández-Seara, Frank Kober, and Thoralf Niendorf. “Noninvasive Renal Perfusion Measurement Using Arterial Spin Labeling (ASL) MRI: Basic Concept.” In Preclinical MRI of the Kidney, 2216:229–39. Methods in Molecular Biology. New York, NY: Humana, 2021. https://doi.org/10.1007/978-1-0716-0978-1_13.
Sourdon, Joevin, Caterina Facchin, Anaïs Certain, Thomas Viel, Blaise Robin, Franck Lager, Carmen Marchiol, et al. “Sunitinib-Induced Cardiac Hypertrophy and the Endothelin Axis.” Theranostics 11, no. 8 (2021): 3830–38. https://doi.org/10.7150/thno.49837.
Lyu, Zhenbin, Ling Ding, Aura Tintaru, and Ling Peng. “Self-Assembling Supramolecular Dendrimers for Biomedical Applications: Lessons Learned from Poly(Amidoamine) Dendrimers.” Accounts of Chemical Research 53, no. 12 (December 15, 2020): 2936–49. https://doi.org/10.1021/acs.accounts.0c00589.
Castelli, Maxime, Arnaud Maurin, Axel Bartoli, Michael Dassa, Baptiste Marchi, Julie Finance, Jean-Christophe Lagier, et al. “Prevalence and Risk Factors for Lung Involvement on Low-Dose Chest CT (LDCT) in a Paucisymptomatic Population of 247 Patients Affected by COVID-19.” Insights into Imaging 11, no. 1 (November 17, 2020): 117. https://doi.org/10.1186/s13244-020-00939-7.