Cardiovascular System


Mission statement

We develop MR biomarkers to give new insights into metabolic, physiological and functional alterations in cardiovascular diseases. Our work aims at improving prognosis, diagnosis and therapeutic follow up. We target pathologies leading to diffuse alterations of heart and blood vessels (diabetes and obesity, heart transplantation, dilated cardiomyopathy).

Development of original methods focuses on arterial spin labeling (ASL) perfusion MRI, advanced sampling and reconstruction strategies, flow imaging, sodium MRI and proton and phosphorus spectroscopy. We propose a comprehensive and transversal characterization of the cardiovascular system scaling from isolated perfused rodent heart model to in vivo rodent models and human studies. Thus, a wide range of MR modalities is exploited to cover each scientific domain with dedicated methodology.

The team is inherently multidisciplinary with expertise in biochemistry and physics as well as in various medical disciplines: namely cardiology, radiology and vascular surgery.

Research Topics

Artificial intelligence and cardiac image segmentation
Emerging Technologies in Diabetes and Cardiometabolic Health
Experimental models of type-2 diabetes
Metabolism and microcirculation in cardiovascular pathologies
Nutrition, Lipids and Health Programming (DOHaD concept)
Preclinical and clinical perfusion MRI
Tissue Remodeling in cardiomyopathies
Vascular MRI

Publications

Božić-Iven, Maša, Stanislas Rapacchi, Qian Tao, Iain Pierce, George Thornton, Christian Nitsche, Thomas A. Treibel, Lothar R. Schad, and Sebastian Weingärtner. “Improved Reproducibility for Myocardial ASL: Impact of Physiological and Acquisition Parameters.” Magnetic Resonance in Medicine, September 5, 2023. https://doi.org/10.1002/mrm.29834.
Aramendía-Vidaurreta, Verónica, and Frank Kober. “Chapter 14 - Perfusion MRI in the Heart: Arterial Spin Labeling.” In Advances in Magnetic Resonance Technology and Applications, edited by Hai-Ling Margaret Cheng and Gustav J. Strijkers, 11:337–66. Quantitative Perfusion MRI. Academic Press, 2023. https://doi.org/10.1016/B978-0-323-95209-5.00008-8.
Kober, Frank. “Noninvasive Cardiovascular Imaging in Preclinical Research: Do We Get New Biomarkers Usable in Humans?” JACC. Basic to Translational Science 8, no. 7 (July 2023): 817–19. https://doi.org/10.1016/j.jacbts.2023.02.009.
Azogui, Ron, Alizee Porto, Maxime Castelli, Virgile Omnes, Mariangela De Masi, Michel Bartoli, Philippe Piquet, et al. “In Marfan Syndrome and Related Diseases, STABILISE Technique Should Be Used with Care: Results from a Volumetric Comparative Study of Endovascular Treatment for Aortic Dissection.” Journal of Clinical Medicine 12, no. 13 (June 29, 2023): 4378. https://doi.org/10.3390/jcm12134378.
Lezoualc’h, Frank, Lina Badimon, Hana Baker, Monique Bernard, Gabor Czibik, Rudolf A de Boer, Thomas D’Humières, et al. “Diabetic Cardiomyopathy: The Need for Adjusting Experimental Models to Meet Clinical Reality.” Cardiovascular Research 119, no. 5 (May 1, 2023): 1130–45. https://doi.org/10.1093/cvr/cvac152.
Choquet, Caroline, Pierre Sicard, Juliette Vahdat, Thi Hong Minh Nguyen, Frank Kober, Isabelle Varlet, Monique Bernard, et al. “Nkx2-5 Loss of Function in the His-Purkinje System Hampers Its Maturation and Leads to Mechanical Dysfunction.” Journal of Cardiovascular Development and Disease 10, no. 5 (May 2023): 194. https://doi.org/10.3390/jcdd10050194.
Ogier, Augustin C., Stanislas Rapacchi, and Marc-Emmanuel Bellemare. “Four-Dimensional Reconstruction and Characterization of Bladder Deformations.” Computer Methods and Programs in Biomedicine 237 (April 29, 2023): 107569. https://doi.org/10.1016/j.cmpb.2023.107569.
Debbi, Kawtar, Paul Habert, Anaïs Grob, Anderson Loundou, Pascale Siles, Axel Bartoli, and Alexis Jacquier. “Radiomics Model to Classify Mammary Masses Using Breast DCE-MRI Compared to the BI-RADS Classification Performance.” Insights into Imaging 14, no. 1 (April 13, 2023): 64. https://doi.org/10.1186/s13244-023-01404-x.
Porto, Alizée, Virgile Omnes, Michel A. Bartoli, Ron Azogui, Noémie Resseguier, Mariangela De Masi, Laurence Bal, et al. “Reintervention of Residual Aortic Dissection after Type A Aortic Repair: Results of a Prospective Follow-Up at 5 Years.” Journal of Clinical Medicine 12, no. 6 (March 18, 2023): 2363. https://doi.org/10.3390/jcm12062363.
Boyer, Jérémy, Axel Bartoli, Pierre Deharo, Antoine Vaillier, Jérôme Ferrara, Pierre-Antoine Barral, Nicolas Jaussaud, et al. “Feasibility of Non-Invasive Coronary Artery Disease Screening with Coronary CT Angiography before Transcatheter Aortic Valve Implantation.” Journal of Clinical Medicine 12, no. 6 (March 15, 2023): 2285. https://doi.org/10.3390/jcm12062285.
Arega, Tewodros Weldebirhan, Stéphanie Bricq, François Legrand, Alexis Jacquier, Alain Lalande, and Fabrice Meriaudeau. “Automatic Uncertainty-Based Quality Controlled T1 Mapping and ECV Analysis from Native and Post-Contrast Cardiac T1 Mapping Images Using Bayesian Vision Transformer.” Medical Image Analysis 86 (February 15, 2023): 102773. https://doi.org/10.1016/j.media.2023.102773.
Cadour, Farah, Morgane Quemeneur, Loic Biere, Erwan Donal, Zakarya Bentatou, Jean-Christophe Eicher, François Roubille, et al. “Prognostic Value of Cardiovascular Magnetic Resonance T1 Mapping and Extracellular Volume Fraction in Nonischemic Dilated Cardiomyopathy.” Journal of Cardiovascular Magnetic Resonance: Official Journal of the Society for Cardiovascular Magnetic Resonance 25, no. 1 (February 6, 2023): 7. https://doi.org/10.1186/s12968-023-00919-y.
Garcia Hernandez, Armando, Pierre Fau, Julien Wojak, Hugues Mailleux, Mohamed Benkreira, Stanislas Rapacchi, and Mouloud Adel. “Synthetic Computed Tomography Generation for Abdominal Adaptive Radiotherapy Using Low-Field Magnetic Resonance Imaging.” Physics and Imaging in Radiation Oncology 25 (January 2023): 100425. https://doi.org/10.1016/j.phro.2023.100425.
Soghomonian, Astrid, Anne Dutour, Nadjia Kachenoura, Franck Thuny, Adele Lasbleiz, Patricia Ancel, Robin Cristofari, et al. “Is Increased Myocardial Triglyceride Content Associated with Early Changes in Left Ventricular Function? A 1H-MRS and MRI Strain Study.” Frontiers in Endocrinology 14 (2023): 1181452. https://doi.org/10.3389/fendo.2023.1181452.
Bernard, Monique. “Editorial for ‘Differential Adaptation of Biventricular Myocardial Kinetic Energy in Patients with Repaired Tetralogy of Fallot Assessed by MR Tissue Phase Mapping.’” Journal of Magnetic Resonance Imaging 57, no. 5 (2023): 1505–6. https://doi.org/10.1002/jmri.28417.
Henry, J. A., I. Abdesselam, O. Deal, A. J. Lewis, J. Rayner, M. Bernard, A. Dutour, et al. “Changes in Epicardial and Visceral Adipose Tissue Depots Following Bariatric Surgery and Their Effect on Cardiac Geometry.” Frontiers in Endocrinology 14 (2023): 1092777. https://doi.org/10.3389/fendo.2023.1092777.
Kober, Frank, Astrid Soghomonian, and Anne Dutour. “Editorial for ‘Effect of Obesity on Left Ventricular Remodeling and Clinical Outcome in Chinese Patients With Hypertrophic Cardiomyopathy Assessed by Cardiac Magnetic Resonance Imaging.’” Journal of Magnetic Resonance Imaging 57, no. 3 (2023): 810–11. https://doi.org/10.1002/jmri.28339.
Calcagno, Claudia, John A. David, Abdallah G. Motaal, Bram F. Coolen, Thijs Beldman, Alexandra Corbin, Arnav Kak, et al. “Self-Gated, Dynamic Contrast-Enhanced Magnetic Resonance Imaging with Compressed-Sensing Reconstruction for Evaluating Endothelial Permeability in the Aortic Root of Atherosclerotic Mice.” NMR in Biomedicine 36, no. 1 (2023): e4823. https://doi.org/10.1002/nbm.4823.
Aita, Jean-François, Thibault Agripnidis, Benoit Testud, Pierre-Antoine Barral, Alexis Jacquier, Anthony Reyre, Ammar Alnuaimi, et al. “Stenting in Brain Hemodynamic Injury of Carotid Origin Caused by Type A Aortic Dissection: Local Experience and Systematic Literature Review.” Journal of Personalized Medicine 13, no. 1 (December 27, 2022): 58. https://doi.org/10.3390/jpm13010058.
Quiclet, Charline, Martine Armand, Hervé Dubouchaud, Guillaume Vial, Eric Fontaine, Cécile Batandier, and Karine Couturier. “Maternal Training during Lactation Modifies Breast Milk Fatty Acid Composition and Male Offspring Glucose Homeostasis in Rat.” Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1867, no. 12 (December 1, 2022): 159223. https://doi.org/10.1016/j.bbalip.2022.159223.
Marage, Louis, Paul-Michael Walker, Julien Boudet, Pierre Fau, Pierre Debuire, Emmanuelle Clausse, Aurélie Petitfils, Léone Aubignac, Stanislas Rapacchi, and Igor Bessieres. “Characterisation of a Split Gradient Coil Design Induced Systemic Imaging Artefact on 0.35 T MR-Linac Systems.” Physics in Medicine & Biology 68, no. 1 (December 2022): 01NT03. https://doi.org/10.1088/1361-6560/aca876.
Silva-Verissimo, W., F. El Louali, Y. Godio-Raboutet, Lugdivine Leblond, Joevin Sourdon, S. Rapacchi, and Morgane Evin. “Traction Mechanical Characterization of Porcine Mitral Valve Annulus.” Journal of Biomechanics 146 (November 20, 2022): 111396. https://doi.org/10.1016/j.jbiomech.2022.111396.
Barral, Pierre-Antoine, Mariangela De Masi, Axel Bartoli, Paul Beunon, Arnaud Gallon, Farouk Tradi, Jean-François Hak, Marine Gaudry, and Alexis Jacquier. “Angio Cone-Beam CT (Angio-CBCT) and 3D Road-Mapping for the Detection of Spinal Cord Vascularization in Patients Requiring Treatment for a Thoracic Aortic Lesion: A Feasibility Study.” Journal of Personalized Medicine 12, no. 11 (November 11, 2022): 1890. https://doi.org/10.3390/jpm12111890.
Alqahtani, Mubarak, Amandine Claudinot, Marine Gaudry, Axel Bartoli, Pierre Antoine Barral, Vincent Vidal, Louis Boyer, et al. “Endovascular Management of Vascular Complications in Ehlers-Danlos Syndrome Type IV.” Journal of Clinical Medicine 11, no. 21 (October 27, 2022): 6344. https://doi.org/10.3390/jcm11216344.
Gaudry, Marine, Carine Guivier-Curien, Arnaud Blanchard, Alizée Porto, Laurence Bal, Virgile Omnes, Mariangela De Masi, et al. “Volume Analysis to Predict the Long-Term Evolution of Residual Aortic Dissection after Type A Repair.” Journal of Cardiovascular Development and Disease 9, no. 10 (October 12, 2022): 349. https://doi.org/10.3390/jcdd9100349.
Lutz, Norbert W., and Monique Bernard. “Methodological Developments for Metabolic NMR Spectroscopy from Cultured Cells to Tissue Extracts: Achievements, Progress and Pitfalls.” Molecules (Basel, Switzerland) 27, no. 13 (June 30, 2022): 4214. https://doi.org/10.3390/molecules27134214.
Cadour, Farah, Jennifer Cautela, Stanislas Rapacchi, Arthur Varoquaux, Paul Habert, François Arnaud, Alexis Jacquier, et al. “Cardiac MRI Features and Prognostic Value in Immune Checkpoint Inhibitor–Induced Myocarditis.” Radiology 303, no. 3 (June 2022): 512–21. https://doi.org/10.1148/radiol.211765.
Quast, Christine, Frank Kober, Katrin Becker, Elric Zweck, Jasmina Hoffe, Christoph Jacoby, Vera Flocke, et al. “Multiparametric MRI Identifies Subtle Adaptations for Demarcation of Disease Transition in Murine Aortic Valve Stenosis.” Basic Research in Cardiology 117, no. 1 (May 29, 2022): 29. https://doi.org/10.1007/s00395-022-00936-5.
Hoesl, Michaela A. U., Lothar R. Schad, and Stanislas Rapacchi. “Volumetric 23Na Single and Triple-Quantum Imaging at 7T: 3D-CRISTINA.” Zeitschrift Für Medizinische Physik 32, no. 2 (May 1, 2022): 199–208. https://doi.org/10.1016/j.zemedi.2021.09.001.
Yuan, Wen Lun, Jonathan Y. Bernard, Martine Armand, Catherine Sarté, Marie Aline Charles, and Barbara Heude. “Associations of Maternal Consumption of Dairy Products during Pregnancy with Perinatal Fatty Acids Profile in the EDEN Cohort Study.” Nutrients 14, no. 8 (April 14, 2022): 1636. https://doi.org/10.3390/nu14081636.
Garbi, Aurélie, Martine Armand, Any-Alejand Beltran-Anzola, Catherine Sarté, Véronique Brévaut-Malaty, Barthélémy Tosello, and Catherine Gire. “Effect of Massage with Oil Balanced in Essential Fatty Acids on Development and Lipid Parameters in Very Premature Neonates: A Randomized, Controlled Study.” Children 9, no. 4 (March 25, 2022): 463. https://doi.org/10.3390/children9040463.
Xerri, Alexandre, Frédéric Gallardo, Frank Kober, Calypso Mathieu, Natacha Fourny, Thi Thom Tran, Jean-Louis Mege, et al. “Female Hormones Prevent Sepsis-Induced Cardiac Dysfunction: An Experimental Randomized Study.” Scientific Reports 12, no. 1 (March 23, 2022): 4939. https://doi.org/10.1038/s41598-022-08889-4.
Cadour, Farah, François Silhol, Nicolas Iline, Roch Giorgi, Aurélien Lorthioir, Laurence Amar, Marc Sapoval, et al. “Insights from Intravascular Pressure Measurement of Renal Artery Revascularization in Patients with Fibromuscular Dysplasia: The DYSART Study.” Journal of Vascular Surgery 75, no. 3 (March 1, 2022): 939-949.e1. https://doi.org/10.1016/j.jvs.2021.09.023.
Pirocca, Ugo, Nawale Hadouiri, Axel Bartoli, Thibaud Morcet-Delattre, François Pontana, Hubert Cochet, Vania Tacher, Farah Cadour, Damien Mandry, and Alexis Jacquier. “How Attractive Is Cardiac Imaging to French Radiology Residents?” Diagnostic and Interventional Imaging 103, no. 3 (March 2022): 185–88. https://doi.org/10.1016/j.diii.2021.12.004.
Vergara Gomez, Tania S., Marc Dubois, Kaizad Rustomji, Elodie Georget, Tryfon Antonakakis, Alexandre Vignaud, Stanislas Rapacchi, et al. “Hilbert Fractal Inspired Dipoles for Passive RF Shimming in Ultra-High Field MRI.” Photonics and Nanostructures - Fundamentals and Applications 48 (February 1, 2022): 100988. https://doi.org/10.1016/j.photonics.2021.100988.
Jourdan, Arthur, Stanislas Rapacchi, Maxime Guye, David Bendahan, Catherine Masson, and Thierry Bège. “Dynamic-MRI Quantification of Abdominal Wall Motion and Deformation during Breathing and Muscular Contraction.” Computer Methods and Programs in Biomedicine 217 (January 29, 2022): 106667. https://doi.org/10.1016/j.cmpb.2022.106667.
Daudé, Pierre, Patricia Ancel, Sylviane Confort Gouny, Alexis Jacquier, Frank Kober, Anne Dutour, Monique Bernard, Bénédicte Gaborit, and Stanislas Rapacchi. “Deep-Learning Segmentation of Epicardial Adipose Tissue Using Four-Chamber Cardiac Magnetic Resonance Imaging.” Diagnostics (Basel, Switzerland) 12, no. 1 (January 6, 2022): 126. https://doi.org/10.3390/diagnostics12010126.
Bartoli, Axel, Joris Fournel, Léa Ait-Yahia, Farah Cadour, Farouk Tradi, Badih Ghattas, Sébastien Cortaredona, et al. “Automatic Deep-Learning Segmentation of Epicardial Adipose Tissue from Low-Dose Chest CT and Prognosis Impact on COVID-19.” Cells 11, no. 6 (January 2022): 1034. https://doi.org/10.3390/cells11061034.
Kober, Frank, and Monique Bernard. “Cardiac In Vivo Magnetic Resonance Spectroscopy.” In Encyclopedia of Biophysics, edited by Gordon Roberts and Anthony Watts, 1–4. Berlin, Heidelberg: Springer, 2022. https://doi.org/10.1007/978-3-642-35943-9_10103-1.
Bernard, Monique. “Editorial for ‘Prospective Evaluation of Virtual MR Elastography With Diffusion Weighted Imaging in Subjects With Nonalcoholic Fatty Liver Disease.’” Journal of Magnetic Resonance Imaging 56, no. 5 (2022): 1457–58. https://doi.org/10.1002/jmri.28155.
Rapacchi, Stanislas, Magalie Viallon, and Pierre Croisille. “Editorial for ‘Impact of Temporal Resolution and Methods for Correction on Cardiovascular Magnetic Resonance Perfusion Quantification.’” Journal of Magnetic Resonance Imaging 56, no. 6 (2022): 1720–21. https://doi.org/10.1002/jmri.28402.
Cadour, Farah, Franck Thuny, and Joevin Sourdon. “New Insights in Early Detection of Anticancer Drug-Related Cardiotoxicity Using Perfusion and Metabolic Imaging.” Frontiers in Cardiovascular Medicine 9 (2022): 813883. https://doi.org/10.3389/fcvm.2022.813883.
Boussuges, Alain, Paul Habert, Guillaume Chaumet, Rawah Rouibah, Lea Delorme, Amelie Menard, Matthieu Million, et al. “Diaphragm Dysfunction after Severe COVID-19: An Ultrasound Study.” Frontiers in Medicine 9 (2022): 949281. https://doi.org/10.3389/fmed.2022.949281.
Brui, Ekaterina A., Stanislas Rapacchi, David Bendahan, and Anna E. Andreychenko. “Comparative Analysis of SINC-Shaped and SLR Pulses Performance for Contiguous Multi-Slice Fast Spin-Echo Imaging Using Metamaterial-Based MRI.” Magnetic Resonance Materials in Physics, Biology and Medicine 34, no. 6 (December 1, 2021): 929–38. https://doi.org/10.1007/s10334-021-00937-w.
Dudouet, Pierre, Serge Cammilleri, Eric Guedj, Alexis Jacquier, Didier Raoult, and Carole Eldin. “Aortic 18F-FDG PET/CT Hypermetabolism in Patients with Long COVID: A Retrospective Study.” Clinical Microbiology and Infection 27, no. 12 (December 1, 2021): 1873–75. https://doi.org/10.1016/j.cmi.2021.09.020.
Volff, Maxime, David Tonon, Youri Bommel, Noémie Peres, David Lagier, Geoffray Agard, Alexis Jacquier, et al. “Factors Associated with 90-Day Mortality in Invasively Ventilated Patients with COVID-19 in Marseille, France.” Journal of Clinical Medicine 10, no. 23 (November 30, 2021): 5650. https://doi.org/10.3390/jcm10235650.
Tacher, Vania, Islem Sifaoui, Rym Kharrat, Jean-Nicolas Dacher, Virgile Chevance, Romain Gallet, Emmanuel Teiger, et al. “The Use of Cardiac Computed Tomography Angiography in the Assessment of Percutaneous Left Atrial Appendage Closure – Review and Experts Recommendations Endorsed by the Société Française d’imagerie Cardiaque et Vasculaire Diagnostique et Interventionnelle.” Diagnostic and Interventional Imaging 102, no. 10 (October 1, 2021): 586–92. https://doi.org/10.1016/j.diii.2021.05.010.
Hostalrich, Aurélien, Thomas Mesnard, Raphael Soler, Paul Girardet, Adrien Kaladji, Elixéne Jean Baptiste, Serguei Malikov, et al. “Prospective Multicentre Cohort Study of Fenestrated and Branched Endografts After Failed Endovascular Infrarenal Aortic Aneurysm Repair with Type Ia Endoleak.” European Journal of Vascular and Endovascular Surgery: The Official Journal of the European Society for Vascular Surgery 62, no. 4 (October 2021): 540–48. https://doi.org/10.1016/j.ejvs.2021.06.019.
Préau, Yannis, Sébastien Galie, Pauline Schaepelynck, Martine Armand, and Denis Raccah. “Benefits of a Switch from Intermittently Scanned Continuous Glucose Monitoring (IsCGM) to Real-Time (Rt) CGM in Diabetes Type 1 Suboptimal Controlled Patients in Real-Life: A One-Year Prospective Study §.” Sensors (Basel, Switzerland) 21, no. 18 (September 13, 2021): 6131. https://doi.org/10.3390/s21186131.
Fourny, Natacha, Carole Lan, Monique Bernard, and Martine Desrois. “Male and Female Rats Have Different Physiological Response to High-Fat High-Sucrose Diet but Similar Myocardial Sensitivity to Ischemia-Reperfusion Injury.” Nutrients 13, no. 9 (August 24, 2021): 2914. https://doi.org/10.3390/nu13092914.