Central Nervous System



Mission statement

The main objective of the CNS team is to develop innovative and quantitative pre-clinical and clinical MR methods at high and ultra-high magnetic fields, as well as image analysis techniques, in order to improve in vivo the physiological and pathophysiological characterization of both brain and spinal cord.

Preclinical studies of CNS pathological models help refine, reject, or generate hypotheses regarding the mechanistic basis of diseases by providing detailed structural, functional, and metabolic phenotypes/information associated with pathology.

Clinical MR methods developed by researchers and engineers are driven by clinical questions brought by the clinicians of the team specialized in Multiple Sclerosis, Epilepsy and Spinal Cord Injury. Researches focus on the different ways to characterize the anatomical, microstructural, hemodynamic, metabolic, ionic and functional alterations of the Human CNS.

The CNS team also provides through collaborations an academic platform based on the tools developed for the main topics adapted to characterize other CNS diseases (AD, ALS, Stroke, Parkinson, Schizophrenia, Spinal Cord Injury (LIA iLab-Spine) …).


Research Topics


Publications

Graille-Avy, Lisa, Clemence Boutiere, Camille Rigollet, Marine Perriguey, Audrey Rico, Sarah Demortiere, Pierre Durozard, et al. “Effect of Prior Treatment With Fingolimod on Early and Late Response to Rituximab/Ocrelizumab in Patients With Multiple Sclerosis.” Neurology(R) Neuroimmunology & Neuroinflammation 11, no. 3 (May 2024): e200231. https://doi.org/10.1212/NXI.0000000000200231.
Demortiere, Sarah, Bastien Joubert, Marie Benaiteau, Frederic Hilezian, Clemence Boutiere, Audrey Rico, Natacha Stolowy, et al. “Anti-IgLON5 Disease With Inaugural Bilateral Neuropapillitis.” Neurology 102, no. 8 (April 23, 2024): e209284. https://doi.org/10.1212/WNL.0000000000209284.
Kümpfel, Tania, Katrin Giglhuber, Orhan Aktas, Ilya Ayzenberg, Judith Bellmann-Strobl, Vivien Häußler, Joachim Havla, et al. “Correction to: Update on the Diagnosis and Treatment of Neuromyelitis Optica Spectrum Disorders (NMOSD) - Revised Recommendations of the Neuromyelitis Optica Study Group (NEMOS). Part II: Attack Therapy and Long-Term Management.” Journal of Neurology, April 5, 2024. https://doi.org/10.1007/s00415-024-12288-2.
Horowitz, Tatiana, Eric Guedj, Alexandre Eusebio, Frédérique Fluchère, Jean-Philippe Azulay, Emilien Delmont, and Stephan Grimaldi. “Molecular Imaging in CANVAS: A Contribution for Differential Diagnosis?” Movement Disorders Clinical Practice, April 4, 2024. https://doi.org/10.1002/mdc3.14041.
Tilsley, Penelope, Antoine Moutiez, Alexandre Brodovitch, Mohamed Mounir El Mendili, Benoit Testud, Wafaa Zaaraoui, Annie Verschueren, et al. “Neurofilament Light Chain Levels Interact with Neurodegenerative Patterns and Motor Neuron Dysfunction in Amyotrophic Lateral Sclerosis.” AJNR. American Journal of Neuroradiology, March 28, 2024. https://doi.org/10.3174/ajnr.A8154.
Cruz, Eva Sole, Etienne Fortanier, Frederic Hilezian, Adil Maarouf, Clémence Boutière, Sarah Demortière, Audrey Rico, et al. “Factors Affecting the Topography of Nitrous Oxide-Induced Neurological Complications.” European Journal of Neurology, March 26, 2024, e16291. https://doi.org/10.1111/ene.16291.
Jouvenot, Guillaume, Guilhem Courbon, Mathilde Lefort, Fabien Rollot, Romain Casey, Emmanuelle Le Page, Laure Michel, et al. “High-Efficacy Therapy Discontinuation vs Continuation in Patients 50 Years and Older With Nonactive MS.” JAMA Neurology, March 25, 2024, e240395. https://doi.org/10.1001/jamaneurol.2024.0395.
Khamaysa, M., M. Lefort, M. Pélégrini-Issac, A. Lackmy-Vallée, M. M. El Mendili, A. Preuilh, D. Devos, et al. “Quantitative Brainstem and Spinal MRI in Amyotrophic Lateral Sclerosis: Implications for Predicting Noninvasive Ventilation Needs.” Journal of Neurology 271, no. 3 (March 1, 2024): 1235–46. https://doi.org/10.1007/s00415-023-12045-x.
Sole Cruz, E., N. Stolowy, R. Attia, B. Audoin, and S. Demortière. “Acute Posterior Ischemic Optic Neuropathy Associated with a Hypertensive Crisis.” Revue Neurologique 180, no. 3 (March 1, 2024): 218–19. https://doi.org/10.1016/j.neurol.2023.12.002.
Androdias, Géraldine, Louise Noroy, Dimitri Psimaras, Cristina Birzu, Jean Pelletier, Ysoline Beigneux, Pierre Branger, et al. “Impact of Immune Checkpoint Inhibitors on the Course of Multiple Sclerosis.” Neurology(R) Neuroimmunology & Neuroinflammation 11, no. 2 (March 2024): e200202. https://doi.org/10.1212/NXI.0000000000200202.
Collongues, Nicolas, Françoise Durand-Dubief, Christine Lebrun-Frenay, Bertrand Audoin, Xavier Ayrignac, Caroline Bensa, Kévin Bigaut, et al. “Cancer and Multiple Sclerosis: 2023 Recommendations from the French Multiple Sclerosis Society.” Multiple Sclerosis (Houndmills, Basingstoke, England), February 15, 2024, 13524585231223880. https://doi.org/10.1177/13524585231223880.
Benallegue, Nail, Fabien Rollot, Sandrine Wiertlewski, Romain Casey, Marc Debouverie, Anne Kerbrat, Jérôme De Seze, et al. “Highly Effective Therapies as First-Line Treatment for Pediatric-Onset Multiple Sclerosis.” JAMA Neurology, February 12, 2024. https://doi.org/10.1001/jamaneurol.2023.5566.
Bolton, Thomas A. W., Dimitri Van De Ville, Jean Régis, Tatiana Witjas, Nadine Girard, Marc Levivier, and Constantin Tuleasca. “Dynamic Functional Changes upon Thalamotomy in Essential Tremor Depend on Baseline Brain Morphometry.” Scientific Reports 14, no. 1 (January 31, 2024): 2605. https://doi.org/10.1038/s41598-024-52410-y.
Testud, Benoit, Xavier Carle, Claire Costes, Jean-François Hak, and Maxime Guye. “Added Value of Ultrahigh-Resolution 7T MRI in Dural Arteriovenous Fistulas.” Stroke, January 25, 2024. https://doi.org/10.1161/STROKEAHA.123.045930.
Jeantin, Lina, Edouard Januel, Pierre Labauge, Elisabeth Maillart, Jérôme de Seze, Hélène Zéphir, Jean Pelletier, et al. “COVID-19 Outcomes in Patients with Multiple Sclerosis: Understanding Changes from 2020 to 2022.” Multiple Sclerosis (Houndmills, Basingstoke, England), January 21, 2024, 13524585231218148. https://doi.org/10.1177/13524585231218149.
Venet, Melany, Anne Lepine, Adil Maarouf, Damien Biotti, Clémence Boutiere, Olivier Casez, Mikael Cohen, et al. “Control of Disease Activity with Large Extended-Interval Dosing of Rituximab/Ocrelizumab in Highly Active Pediatric Multiple Sclerosis.” Multiple Sclerosis (Houndmills, Basingstoke, England), January 2, 2024, 13524585231223068. https://doi.org/10.1177/13524585231223069.
Kümpfel, Tania, Katrin Giglhuber, Orhan Aktas, Ilya Ayzenberg, Judith Bellmann-Strobl, Vivien Häußler, Joachim Havla, et al. “Update on the Diagnosis and Treatment of Neuromyelitis Optica Spectrum Disorders (NMOSD) – Revised Recommendations of the Neuromyelitis Optica Study Group (NEMOS). Part II: Attack Therapy and Long-Term Management.” Journal of Neurology 271, no. 1 (January 1, 2024): 141–76. https://doi.org/10.1007/s00415-023-11910-z.
Perles-Barbacaru, Adriana T. “Editorial for ‘Feasibility of Multiparametric Perfusion Assessment in Diabetic Foot Ulcer Using Intravoxel Incoherent Motion and Blood Oxygenation-Level Dependent MRI.’” Journal of Magnetic Resonance Imaging 59, no. 5 (2024): 1567–68. https://doi.org/10.1002/jmri.28953.
Desnous, Beatrice, Guillaume Carles, Florence Riccardi, Nathalie Stremler, Melissa Baravalle, Fedouah El-Louali, Benoit Testud, and Mathieu Milh. “Diffuse Interstitial Lung Disease in a Male Fetus with Periventricular Nodular Heterotopia and Filamin A Mosaic Variant.” Prenatal Diagnosis 44, no. 3 (2024): 364–68. https://doi.org/10.1002/pd.6505.
Braun, Bente, Felix Fischbach, Johanna Richter, Lena Kristina Pfeffer, Heike Fay, Stefanie Reinhardt, Manuel A. Friese, et al. “Benefits of AHSCT over Alemtuzumab in Patients with Multiple Sclerosis besides Disability and Relapses: Sustained Improvement in Cognition and Quality of Life.” Multiple Sclerosis and Related Disorders 82 (December 27, 2023): 105414. https://doi.org/10.1016/j.msard.2023.105414.
Lebret, Anna, Simon Lévy, Nikolai Pfender, Mazda Farshad, Franziska C. S. Altorfer, Virginie Callot, Armin Curt, Patrick Freund, and Maryam Seif. “Investigation of Perfusion Impairment in Degenerative Cervical Myelopathy beyond the Site of Cord Compression.” Scientific Reports 13, no. 1 (December 19, 2023): 22660. https://doi.org/10.1038/s41598-023-49896-3.
Rollot, Fabien, Zoé Uhry, Emmanuelle Dantony, Sandra Vukusic, Marc Debouverie, Emmanuelle Le Page, Jonathan Ciron, et al. “Comparison of 2 Methods for Estimating Multiple Sclerosis–Related Mortality.” Neurology 101, no. 24 (December 12, 2023): e2483–96. https://doi.org/10.1212/WNL.0000000000207925.
Duchow, Ankelien, Judith Bellmann-Strobl, Tim Friede, Orhan Aktas, Klemens Angstwurm, Ilya Ayzenberg, Achim Berthele, et al. “Time to Disability Milestones and Annualized Relapse Rates in NMOSD and MOGAD.” Annals of Neurology, December 12, 2023. https://doi.org/10.1002/ana.26858.
Jin, Sameer Omer, Inés Mérida, Ioannis Stavropoulos, Robert D. C. Elwes, Tanya Lam, Eric Guedj, Nadine Girard, Nicolas Costes, and Alexander Hammers. “Characterisation of a Novel [18F]FDG Brain PET Database and Combination with a Second Database for Optimising Detection of Focal Abnormalities, Using Focal Cortical Dysplasia as an Example.” EJNMMI Research 13, no. 1 (November 15, 2023): 98. https://doi.org/10.1186/s13550-023-01023-z.
Rosenkranz, Sina C., Lilija Gutmann, Arzu Ceylan Has Silemek, Michael Dorr, Vivien Häußler, Margareta Lüpke, Andrea Mönch, et al. “Visual Function Resists Early Neurodegeneration in the Visual System in Primary Progressive Multiple Sclerosis.” Journal of Neurology, Neurosurgery, and Psychiatry 94, no. 11 (November 2023): 924–33. https://doi.org/10.1136/jnnp-2023-331183.
Chakraborty, Sudesna, Sun Kyun Lee, Sarah M. Arnold, Roy A. M. Haast, Ali R. Khan, and Taylor W. Schmitz. “Focal Acetylcholinergic Modulation of the Human Midcingulo-Insular Network during Attention: Meta-Analytic Neuroimaging and Behavioral Evidence.” Journal of Neurochemistry, October 21, 2023. https://doi.org/10.1111/jnc.15990.
Tessier, Anthony, Anthony J. Ruze, Isabelle Varlet, Estelle M. H. Laïb, Emilien Royer, Monique Bernard, Angèle Viola, and Teodora-Adriana Perles-Barbacaru. “Quantitative MRI of Gd-DOTA Accumulation in the Mouse Brain After Intraperitoneal Administration: Validation by Mass Spectrometry.” Journal of Magnetic Resonance Imaging: JMRI, October 9, 2023. https://doi.org/10.1002/jmri.29034.
Tilsley, Penelope, Isanbert Arun Strohmeyer, Inga Heinrich, Friederike Rosenthal, Stefan Patra, Karl Heinz Schulz, Sina C. Rosenkranz, et al. “Correction to: Physical Fitness Moderates the Association between Brain Network Impairment and Both Motor Function and Cognition in Progressive Multiple Sclerosis.” Journal of Neurology 270, no. 10 (October 2023): 4889. https://doi.org/10.1007/s00415-023-11874-0.
Tilsley, Penelope, Isanbert Arun Strohmeyer, Inga Heinrich, Friederike Rosenthal, Stefan Patra, Karl Heinz Schulz, Sina C. Rosenkranz, et al. “Physical Fitness Moderates the Association between Brain Network Impairment and Both Motor Function and Cognition in Progressive Multiple Sclerosis.” Journal of Neurology 270, no. 10 (October 2023): 4876–88. https://doi.org/10.1007/s00415-023-11806-y.
El Mendili, Mohamed Mounir, Annie Verschueren, Jean-Philippe Ranjeva, Maxime Guye, Shahram Attarian, Wafaa Zaaraoui, and Aude-Marie Grapperon. “Association between Brain and Upper Cervical Spinal Cord Atrophy Assessed by MRI and Disease Aggressiveness in Amyotrophic Lateral Sclerosis.” Neuroradiology 65, no. 9 (September 1, 2023): 1395–1403. https://doi.org/10.1007/s00234-023-03191-0.
Claverie, Roxane, Marine Perriguey, Audrey Rico, Clemence Boutiere, Sarah Demortiere, Pierre Durozard, Frederic Hilezian, et al. “Efficacy of Rituximab Outlasts B-Cell Repopulation in Multiple Sclerosis: Time to Rethink Dosing?” Neurology(R) Neuroimmunology & Neuroinflammation 10, no. 5 (September 2023): e200152. https://doi.org/10.1212/NXI.0000000000200152.
Testud, B., N. Fabiani, S. Demortière, S. Mchinda, N. L. Medina, J. Pelletier, M. Guye, B. Audoin, J. P. Stellmann, and V. Callot. “Contribution of the MP2RAGE 7T Sequence in MS Lesions of the Cervical Spinal Cord.” AJNR. American Journal of Neuroradiology 44, no. 9 (September 2023): 1101–7. https://doi.org/10.3174/ajnr.A7964.
Soustelle, Lucas, Thomas Troalen, Andreea Hertanu, Jean-Philippe Ranjeva, Maxime Guye, Gopal Varma, David C. Alsop, Guillaume Duhamel, and Olivier M. Girard. “Quantitative Magnetization Transfer MRI Unbiased by On-Resonance Saturation and Dipolar Order Contributions.” Magnetic Resonance in Medicine 90, no. 3 (September 2023): 875–93. https://doi.org/10.1002/mrm.29678.
Demortiere, Sarah, Adil Maarouf, Audrey Rico, Clemence Boutiere, Frederic Hilezian, Pierre Durozard, Jean Pelletier, and Bertrand Audoin. “Disease Evolution in Women With Highly Active MS Who Suspended Natalizumab During Pregnancy vs Rituximab/Ocrelizumab Before Conception.” Neurology(R) Neuroimmunology & Neuroinflammation 10, no. 5 (September 2023): e200161. https://doi.org/10.1212/NXI.0000000000200161.
Heim, Xavier, Anne Michele Hubert, Issam Raouak, Anthony Charles Nzepa, Jean-Louis Mege, Emilien Delmont, Shahram Attarian, et al. “Validation of ELISA Assays for the Calculation of FLC Indices for the Diagnosis of Intrathecal Immunoglobulin Synthesis.” Clinical Chemistry and Laboratory Medicine (CCLM) 61, no. 9 (August 1, 2023): 1623–29. https://doi.org/10.1515/cclm-2022-0602.
Lee, Hyo M, Seok-Jun Hong, Ravnoor Gill, Benoit Caldairou, Irene Wang, Jian-guo Zhang, Francesco Deleo, et al. “Multimodal Mapping of Regional Brain Vulnerability to Focal Cortical Dysplasia.” Brain 146, no. 8 (August 1, 2023): 3404–15. https://doi.org/10.1093/brain/awad060.
Brocard, Guillaume, Romain Casey, Nathalie Dufay, Romain Marignier, Laure Michel, Michael Hisbergues, Xavier Ayrignac, et al. “The Biological Sample Collection of the OFSEP French MS Registry: An Essential Tool Dedicated to Researchers.” Multiple Sclerosis and Related Disorders 77 (July 7, 2023): 104872. https://doi.org/10.1016/j.msard.2023.104872.
Jarius, Sven, Orhan Aktas, Ilya Ayzenberg, Judith Bellmann-Strobl, Achim Berthele, Katrin Giglhuber, Vivien Häußler, et al. “Update on the Diagnosis and Treatment of Neuromyelits Optica Spectrum Disorders (NMOSD) – Revised Recommendations of the Neuromyelitis Optica Study Group (NEMOS). Part I: Diagnosis and Differential Diagnosis.” Journal of Neurology 270, no. 7 (July 1, 2023): 3341–68. https://doi.org/10.1007/s00415-023-11634-0.
Rode, Julie, Julie Pique, Adil Maarouf, Xavier Ayrignac, Bertrand Bourre, Jonathan Ciron, Mikael Cohen, et al. “Time to Steroids Impacts Visual Outcome of Optic Neuritis in MOGAD.” Journal of Neurology, Neurosurgery & Psychiatry 94, no. 4 (April 1, 2023): 309–13. https://doi.org/10.1136/jnnp-2022-330360.
Thiery, Louis, Xavier Carle, Benoit Testud, Gregoire Boulouis, Paul Habert, Farouk Tradi, Anthony Reyre, et al. “Distal Cerebral Vasospasm Treatment Following Aneurysmal Subarachnoid Hemorrhage Using the Comaneci Device: Technical Feasibility and Single-Center Preliminary Results.” Journal of NeuroInterventional Surgery 15, no. 4 (April 1, 2023): 325–29. https://doi.org/10.1136/neurintsurg-2022-018699.
Dollomaja, Borana, Julia Makhalova, Huifang Wang, Fabrice Bartolomei, Viktor Jirsa, and Christophe Bernard. “Personalized Whole Brain Modeling of Status Epilepticus.” Epilepsy & Behavior: E&B 142 (March 30, 2023): 109175. https://doi.org/10.1016/j.yebeh.2023.109175.
Gavoille, Antoine, Fabien Rollot, Romain Casey, Marc Debouverie, Emmanuelle Le Page, Jonathan Ciron, Jerome De Seze, et al. “Investigating the Long-Term Effect of Pregnancy on the Course of Multiple Sclerosis Using Causal Inference.” Neurology 100, no. 12 (March 21, 2023): e1296–1308. https://doi.org/10.1212/WNL.0000000000206774.
Hümmert, Martin W., Franziska Bütow, Daria Tkachenko, Ilya Ayzenberg, Thivya Pakeerathan, Kerstin Hellwig, Luisa Klotz, et al. “Effects of the COVID-19 Pandemic on Patients With NMO Spectrum Disorders and MOG-Antibody-Associated Diseases: COPANMO(G)-Study.” Neurology(R) Neuroimmunology & Neuroinflammation 10, no. 2 (March 2023): e200082. https://doi.org/10.1212/NXI.0000000000200082.
Ridley, Ben, Filomena Morsillo, Wafaa Zaaraoui, and Francesco Nonino. “Variability by Region and Method in Human Brain Sodium Concentrations Estimated by 23Na Magnetic Resonance Imaging: A Meta-Analysis.” Scientific Reports 13, no. 1 (February 24, 2023): 3222. https://doi.org/10.1038/s41598-023-30363-y.
Chen, John J., Eoin P. Flanagan, Sean J. Pittock, Nicole Caroline Stern, Nanthaya Tisavipat, M. Tariq Bhatti, Kevin D. Chodnicki, et al. “Visual Outcomes Following Plasma Exchange for Optic Neuritis: An International Multicenter Retrospective Analysis of 395 Optic Neuritis Attacks.” American Journal of Ophthalmology, February 21, 2023, S0002-9394(23)00066-1. https://doi.org/10.1016/j.ajo.2023.02.013.
Hümmert, Martin W., Carlotta Stern, Friedemann Paul, Ankelien Duchow, Judith Bellmann-Strobl, Ilya Ayzenberg, Carolin Schwake, et al. “Cognition in Patients with Neuromyelitis Optica Spectrum Disorders: A Prospective Multicentre Study of 217 Patients (CogniNMO-Study).” Multiple Sclerosis (Houndmills, Basingstoke, England), February 14, 2023, 13524585231151212. https://doi.org/10.1177/13524585231151212.
Carra-Dallière, Clarisse, Fabien Rollot, Romain Deschamps, Jonathan Ciron, Sandra Vukusic, Bertrand Audoin, Aurélie Ruet, et al. “Pregnancy and Post-Partum in Patients with Myelin-Oligodendrocyte Glycoprotein Antibody-Associated Disease.” Multiple Sclerosis Journal 29, no. 2 (February 1, 2023): 270–76. https://doi.org/10.1177/13524585221134214.
Grimaldi, Stephan, Alexandre Eusebio, Romain Carron, Jean-Marie Regis, Lionel Velly, Jean-Philippe Azulay, and Tatiana Witjas. “Deep Brain Stimulation–Withdrawal Syndrome in Parkinson’s Disease: Risk Factors and Pathophysiological Hypotheses of a Life-Threatening Emergency.” Neuromodulation 26, no. 2 (February 1, 2023): 424–34. https://doi.org/10.1016/j.neurom.2022.09.008.
Sabathé, Camille, Romain Casey, Sandra Vukusic, Emmanuelle Leray, Guillaume Mathey, Jérôme De Sèze, Jonathan Ciron, et al. “Improving the Decision to Switch from First- to Second-Line Therapy in Multiple Sclerosis: A Dynamic Scoring System.” Multiple Sclerosis Journal 29, no. 2 (February 1, 2023): 236–47. https://doi.org/10.1177/13524585221139156.
Wang, Huifang E., Marmaduke Woodman, Paul Triebkorn, Jean-Didier Lemarechal, Jayant Jha, Borana Dollomaja, Anirudh Nihalani Vattikonda, et al. “Delineating Epileptogenic Networks Using Brain Imaging Data and Personalized Modeling in Drug-Resistant Epilepsy.” Science Translational Medicine 15, no. 680 (January 25, 2023): eabp8982. https://doi.org/10.1126/scitranslmed.abp8982.