Central Nervous System


Mission statement

The main objective of the CNS team is to develop innovative and quantitative pre-clinical and clinical MR methods at high and ultra-high magnetic fields, as well as image analysis techniques, in order to improve in vivo the physiological and pathophysiological characterization of both brain and spinal cord.

Preclinical studies of CNS pathological models help refine, reject, or generate hypotheses regarding the mechanistic basis of diseases by providing detailed structural, functional, and metabolic phenotypes/information associated with pathology.

Clinical MR methods developed by researchers and engineers are driven by clinical questions brought by the clinicians of the team specialized in Multiple Sclerosis, Epilepsy and Spinal Cord Injury. Researches focus on the different ways to characterize the anatomical, microstructural, hemodynamic, metabolic, ionic and functional alterations of the Human CNS.

The CNS team also provides through collaborations an academic platform based on the tools developed for the main topics adapted to characterize other CNS diseases (AD, ALS, Stroke, Parkinson, Schizophrenia, Spinal Cord Injury (LIA iLab-Spine) …).

Research Topics

Brain Imaging
PHENIQS - Physics and digital technologies for quantitative imaging of the central nervous system
Preclinical Imaging
Spinal Cord Imaging
Translational Neuroscience and Clinical Applications

Publications

Pakeerathan, T., J. Havla, C. Schwake, A. Salmen, M. Ringelstein, O. Aktas, M. Weise, et al. “Rapid Differentiation of MOGAD and MS after a Single Optic Neuritis.” Journal of Neurology, September 9, 2024. https://doi.org/10.1007/s00415-024-12666-w.
Lévi-Strauss, Julie, Julia Makhalova, Samuel Medina Villalon, Romain Carron, Christian G. Bénar, and Fabrice Bartolomei. “Transient Alteration of Awareness Triggered by Direct Electrical Stimulation of the Brain.” Brain Stimulation, August 30, 2024, S1935-861X(24)00154-2. https://doi.org/10.1016/j.brs.2024.08.013.
Passoke, Sarah, Carlotta Stern, Vivien Häußler, Tania Kümpfel, Joachim Havla, Daniel Engels, Sven Jarius, et al. “Cognition in Patients with Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease: A Prospective, Longitudinal, Multicentre Study of 113 Patients (CogniMOG-Study).” Journal of Neurology, Neurosurgery, and Psychiatry, July 30, 2024, jnnp-2024-333994. https://doi.org/10.1136/jnnp-2024-333994.
Köksal-Ersöz, Elif, Julia Makhalova, Maxime Yochum, Christian-G. Bénar, Maxime Guye, Fabrice Bartolomei, Fabrice Wendling, and Isabelle Merlet. “Whole-Brain Simulation of Interictal Epileptic Discharges for Patient-Specific Interpretation of Interictal SEEG Data.” Neurophysiologie Clinique = Clinical Neurophysiology 54, no. 5 (July 18, 2024): 103005. https://doi.org/10.1016/j.neucli.2024.103005.
Jougleux, C., H. Joly, H. Brissard, B. Lenne, S. François, F. Hamelin, N. Derache, et al. “French Consensus Procedure for Neuropsychological Assessment in Multiple Sclerosis.” Revue Neurologique, July 12, 2024, S0035-3787(24)00558-7. https://doi.org/10.1016/j.neurol.2024.06.005.
Krämer, Julia, Carolin Balloff, Margit Weise, Valeria Koska, Yannik Uthmeier, Isabell Esderts, Mai Nguyen-Minh, et al. “Evolution of Retinal Degeneration and Prediction of Disease Activity in Relapsing and Progressive Multiple Sclerosis.” Nature Communications 15, no. 1 (June 19, 2024): 5243. https://doi.org/10.1038/s41467-024-49309-7.
Pinto, Joana, Allison McGee, Hendrik Mattern, Karin Markenroth Bloch, Roy A. M. Haast, Thomas Küstner, and S. Johanna Vannesjo. “ESMRMB 2024 Focus Topic ‘MR Beyond Structures: The Dynamic Body at Different Scales.’” Magma (New York, N.Y.), June 8, 2024. https://doi.org/10.1007/s10334-024-01175-6.
Grimaldi, Stephan, Arnaud Le Troter, Mohamed Mounir El Mendili, Hugo Dary, Jean-Philippe Azulay, Wafaa Zaaraoui, Jean-Philippe Ranjeva, Alexandre Eusebio, Ludovic de Rochefort, and Maxime Guye. “Energetic Dysfunction and Iron Overload in Early Parkinson’s Disease: Two Distinct Mechanisms?” Parkinsonism & Related Disorders 124 (May 6, 2024): 106996. https://doi.org/10.1016/j.parkreldis.2024.106996.
Maarouf, Adil, Jan Patrick Stellmann, Audrey Rico, Clemence Boutiere, Sarah Demortiere, Pierre Durozard, Wafaa Zaaraoui, Jean-Philippe Ranjeva, Jean Pelletier, and Bertrand Audoin. “Active and Non-Active Progression Independent of Relapse Activity within the First 20 Years of Relapsing Multiple Sclerosis.” Journal of Neurology, Neurosurgery, and Psychiatry, May 6, 2024, jnnp-2024-333597. https://doi.org/10.1136/jnnp-2024-333597.
Durozard, Pierre, Adil Maarouf, Wafaa Zaaraoui, Jan-Patrick Stellmann, Clémence Boutière, Audrey Rico, Sarah Demortière, et al. “Cortical Lesions as an Early Hallmark of Multiple Sclerosis: Visualization by 7 T MRI.” Investigative Radiology, May 2, 2024. https://doi.org/10.1097/RLI.0000000000001082.
Graille-Avy, Lisa, Clemence Boutiere, Camille Rigollet, Marine Perriguey, Audrey Rico, Sarah Demortiere, Pierre Durozard, et al. “Effect of Prior Treatment With Fingolimod on Early and Late Response to Rituximab/Ocrelizumab in Patients With Multiple Sclerosis.” Neurology(R) Neuroimmunology & Neuroinflammation 11, no. 3 (May 2024): e200231. https://doi.org/10.1212/NXI.0000000000200231.
Demortiere, Sarah, Bastien Joubert, Marie Benaiteau, Frederic Hilezian, Clemence Boutiere, Audrey Rico, Natacha Stolowy, et al. “Anti-IgLON5 Disease With Inaugural Bilateral Neuropapillitis.” Neurology 102, no. 8 (April 23, 2024): e209284. https://doi.org/10.1212/WNL.0000000000209284.
Kümpfel, Tania, Katrin Giglhuber, Orhan Aktas, Ilya Ayzenberg, Judith Bellmann-Strobl, Vivien Häußler, Joachim Havla, et al. “Correction to: Update on the Diagnosis and Treatment of Neuromyelitis Optica Spectrum Disorders (NMOSD) - Revised Recommendations of the Neuromyelitis Optica Study Group (NEMOS). Part II: Attack Therapy and Long-Term Management.” Journal of Neurology, April 5, 2024. https://doi.org/10.1007/s00415-024-12288-2.
Horowitz, Tatiana, Eric Guedj, Alexandre Eusebio, Frédérique Fluchère, Jean-Philippe Azulay, Emilien Delmont, and Stephan Grimaldi. “Molecular Imaging in CANVAS: A Contribution for Differential Diagnosis?” Movement Disorders Clinical Practice, April 4, 2024. https://doi.org/10.1002/mdc3.14041.
Tilsley, Penelope, Antoine Moutiez, Alexandre Brodovitch, Mohamed Mounir El Mendili, Benoit Testud, Wafaa Zaaraoui, Annie Verschueren, et al. “Neurofilament Light Chain Levels Interact with Neurodegenerative Patterns and Motor Neuron Dysfunction in Amyotrophic Lateral Sclerosis.” AJNR. American Journal of Neuroradiology, March 28, 2024. https://doi.org/10.3174/ajnr.A8154.
Cruz, Eva Sole, Etienne Fortanier, Frederic Hilezian, Adil Maarouf, Clémence Boutière, Sarah Demortière, Audrey Rico, et al. “Factors Affecting the Topography of Nitrous Oxide-Induced Neurological Complications.” European Journal of Neurology, March 26, 2024, e16291. https://doi.org/10.1111/ene.16291.
Jouvenot, Guillaume, Guilhem Courbon, Mathilde Lefort, Fabien Rollot, Romain Casey, Emmanuelle Le Page, Laure Michel, et al. “High-Efficacy Therapy Discontinuation vs Continuation in Patients 50 Years and Older With Nonactive MS.” JAMA Neurology, March 25, 2024, e240395. https://doi.org/10.1001/jamaneurol.2024.0395.
Benallegue, Nail, Fabien Rollot, Sandrine Wiertlewski, Romain Casey, Marc Debouverie, Anne Kerbrat, Jérôme De Seze, et al. “Highly Effective Therapies as First-Line Treatment for Pediatric-Onset Multiple Sclerosis.” JAMA Neurology 81, no. 3 (March 1, 2024): 273–82. https://doi.org/10.1001/jamaneurol.2023.5566.
Guérémy, Alexandre, José Boucraut, John Boudjarane, Aude-Marie Grapperon, Etienne Fortanier, Laure Farnault, Jean Gabert, et al. “Clinical, Biological, Electrophysiological and Therapeutic Profile of Patients with Anti-MAG Neuropathy According to MYD88L265P and CXCR4 Mutations and Underlying Haemopathy.” Journal of Neurology 271, no. 3 (March 1, 2024): 1320–30. https://doi.org/10.1007/s00415-023-12068-4.
Khamaysa, M., M. Lefort, M. Pélégrini-Issac, A. Lackmy-Vallée, M. M. El Mendili, A. Preuilh, D. Devos, et al. “Quantitative Brainstem and Spinal MRI in Amyotrophic Lateral Sclerosis: Implications for Predicting Noninvasive Ventilation Needs.” Journal of Neurology 271, no. 3 (March 1, 2024): 1235–46. https://doi.org/10.1007/s00415-023-12045-x.
Sole Cruz, E., N. Stolowy, R. Attia, B. Audoin, and S. Demortière. “Acute Posterior Ischemic Optic Neuropathy Associated with a Hypertensive Crisis.” Revue Neurologique 180, no. 3 (March 1, 2024): 218–19. https://doi.org/10.1016/j.neurol.2023.12.002.
Androdias, Géraldine, Louise Noroy, Dimitri Psimaras, Cristina Birzu, Jean Pelletier, Ysoline Beigneux, Pierre Branger, et al. “Impact of Immune Checkpoint Inhibitors on the Course of Multiple Sclerosis.” Neurology(R) Neuroimmunology & Neuroinflammation 11, no. 2 (March 2024): e200202. https://doi.org/10.1212/NXI.0000000000200202.
Collongues, Nicolas, Françoise Durand-Dubief, Christine Lebrun-Frenay, Bertrand Audoin, Xavier Ayrignac, Caroline Bensa, Kévin Bigaut, et al. “Cancer and Multiple Sclerosis: 2023 Recommendations from the French Multiple Sclerosis Society.” Multiple Sclerosis (Houndmills, Basingstoke, England), February 15, 2024, 13524585231223880. https://doi.org/10.1177/13524585231223880.
Bolton, Thomas A. W., Dimitri Van De Ville, Jean Régis, Tatiana Witjas, Nadine Girard, Marc Levivier, and Constantin Tuleasca. “Dynamic Functional Changes upon Thalamotomy in Essential Tremor Depend on Baseline Brain Morphometry.” Scientific Reports 14, no. 1 (January 31, 2024): 2605. https://doi.org/10.1038/s41598-024-52410-y.
Testud, Benoit, Xavier Carle, Claire Costes, Jean-François Hak, and Maxime Guye. “Added Value of Ultrahigh-Resolution 7T MRI in Dural Arteriovenous Fistulas.” Stroke, January 25, 2024. https://doi.org/10.1161/STROKEAHA.123.045930.
Jeantin, Lina, Edouard Januel, Pierre Labauge, Elisabeth Maillart, Jérôme de Seze, Hélène Zéphir, Jean Pelletier, et al. “COVID-19 Outcomes in Patients with Multiple Sclerosis: Understanding Changes from 2020 to 2022.” Multiple Sclerosis (Houndmills, Basingstoke, England), January 21, 2024, 13524585231218148. https://doi.org/10.1177/13524585231218149.
Venet, Melany, Anne Lepine, Adil Maarouf, Damien Biotti, Clémence Boutiere, Olivier Casez, Mikael Cohen, et al. “Control of Disease Activity with Large Extended-Interval Dosing of Rituximab/Ocrelizumab in Highly Active Pediatric Multiple Sclerosis.” Multiple Sclerosis (Houndmills, Basingstoke, England), January 2, 2024, 13524585231223068. https://doi.org/10.1177/13524585231223069.
Kümpfel, Tania, Katrin Giglhuber, Orhan Aktas, Ilya Ayzenberg, Judith Bellmann-Strobl, Vivien Häußler, Joachim Havla, et al. “Update on the Diagnosis and Treatment of Neuromyelitis Optica Spectrum Disorders (NMOSD) – Revised Recommendations of the Neuromyelitis Optica Study Group (NEMOS). Part II: Attack Therapy and Long-Term Management.” Journal of Neurology 271, no. 1 (January 1, 2024): 141–76. https://doi.org/10.1007/s00415-023-11910-z.
Chakraborty, Sudesna, Sun Kyun Lee, Sarah M. Arnold, Roy A. M. Haast, Ali R. Khan, and Taylor W. Schmitz. “Focal Acetylcholinergic Modulation of the Human Midcingulo-Insular Network during Attention: Meta-Analytic Neuroimaging and Behavioral Evidence.” Journal of Neurochemistry 168, no. 4 (2024): 397–413. https://doi.org/10.1111/jnc.15990.
Radunsky, Dvir, Chen Solomon, Neta Stern, Tamar Blumenfeld-Katzir, Shir Filo, Aviv Mezer, Anita Karsa, et al. “A Comprehensive Protocol for Quantitative Magnetic Resonance Imaging of the Brain at 3 Tesla.” PloS One 19, no. 5 (2024): e0297244. https://doi.org/10.1371/journal.pone.0297244.
Wirsich, Jonathan, Giannina Rita Iannotti, Ben Ridley, Elhum A. Shamshiri, Laurent Sheybani, Frédéric Grouiller, Fabrice Bartolomei, et al. “Altered Correlation of Concurrently Recorded EEG-FMRI Connectomes in Temporal Lobe Epilepsy.” Network Neuroscience (Cambridge, Mass.) 8, no. 2 (2024): 466–85. https://doi.org/10.1162/netn_a_00362.
Duchow, Ankelien, Judith Bellmann-Strobl, Tim Friede, Orhan Aktas, Klemens Angstwurm, Ilya Ayzenberg, Achim Berthele, et al. “Time to Disability Milestones and Annualized Relapse Rates in NMOSD and MOGAD.” Annals of Neurology 95, no. 4 (2024): 720–32. https://doi.org/10.1002/ana.26858.
Desnous, Beatrice, Guillaume Carles, Florence Riccardi, Nathalie Stremler, Melissa Baravalle, Fedouah El-Louali, Benoit Testud, and Mathieu Milh. “Diffuse Interstitial Lung Disease in a Male Fetus with Periventricular Nodular Heterotopia and Filamin A Mosaic Variant.” Prenatal Diagnosis 44, no. 3 (2024): 364–68. https://doi.org/10.1002/pd.6505.
Braun, Bente, Felix Fischbach, Johanna Richter, Lena Kristina Pfeffer, Heike Fay, Stefanie Reinhardt, Manuel A. Friese, et al. “Benefits of AHSCT over Alemtuzumab in Patients with Multiple Sclerosis besides Disability and Relapses: Sustained Improvement in Cognition and Quality of Life.” Multiple Sclerosis and Related Disorders 82 (December 27, 2023): 105414. https://doi.org/10.1016/j.msard.2023.105414.
Lebret, Anna, Simon Lévy, Nikolai Pfender, Mazda Farshad, Franziska C. S. Altorfer, Virginie Callot, Armin Curt, Patrick Freund, and Maryam Seif. “Investigation of Perfusion Impairment in Degenerative Cervical Myelopathy beyond the Site of Cord Compression.” Scientific Reports 13, no. 1 (December 19, 2023): 22660. https://doi.org/10.1038/s41598-023-49896-3.
Rollot, Fabien, Zoé Uhry, Emmanuelle Dantony, Sandra Vukusic, Marc Debouverie, Emmanuelle Le Page, Jonathan Ciron, et al. “Comparison of 2 Methods for Estimating Multiple Sclerosis–Related Mortality.” Neurology 101, no. 24 (December 12, 2023): e2483–96. https://doi.org/10.1212/WNL.0000000000207925.
Testud, Benoit, Aurélie Manchon, Jan-Patrick Stellmann, and Jean-Francois Hak. “White Matter Spreading MRI Pattern of Listeria Monocytogenes.” Neurology 101, no. 21 (November 21, 2023): 972–73. https://doi.org/10.1212/WNL.0000000000207803.
Jin, Sameer Omer, Inés Mérida, Ioannis Stavropoulos, Robert D. C. Elwes, Tanya Lam, Eric Guedj, Nadine Girard, Nicolas Costes, and Alexander Hammers. “Characterisation of a Novel [18F]FDG Brain PET Database and Combination with a Second Database for Optimising Detection of Focal Abnormalities, Using Focal Cortical Dysplasia as an Example.” EJNMMI Research 13, no. 1 (November 15, 2023): 98. https://doi.org/10.1186/s13550-023-01023-z.
Rosenkranz, Sina C., Lilija Gutmann, Arzu Ceylan Has Silemek, Michael Dorr, Vivien Häußler, Margareta Lüpke, Andrea Mönch, et al. “Visual Function Resists Early Neurodegeneration in the Visual System in Primary Progressive Multiple Sclerosis.” Journal of Neurology, Neurosurgery, and Psychiatry 94, no. 11 (November 2023): 924–33. https://doi.org/10.1136/jnnp-2023-331183.
Attia, Ruben, Ruben Fitoussi, Kevin Mairot, Sarah Demortiere, Jan-Patrick Stellman, Penelope Tilsley, Bertrand Audoin, Thierry David, and Natacha Stolowy. “Risk Factors Associated with Progression from Papilloedema to Optic Atrophy: Results from a Cohort of 113 Patients.” BMJ Open Ophthalmology 8, no. 1 (November 2023): e001375. https://doi.org/10.1136/bmjophth-2023-001375.
Chorschew, Anna, Firat Kesgin, Judith Bellmann-Strobl, Peter Flachenecker, Insa Schiffmann, Friederike Rosenthal, Patrick Althoff, et al. “Translation and Validation of the Multiple Sclerosis Walking Scale 12 for the German Population - the MSWS-12/D.” Health and Quality of Life Outcomes 21, no. 1 (October 9, 2023): 110. https://doi.org/10.1186/s12955-023-02190-2.
Tilsley, Penelope, Isanbert Arun Strohmeyer, Inga Heinrich, Friederike Rosenthal, Stefan Patra, Karl Heinz Schulz, Sina C. Rosenkranz, et al. “Physical Fitness Moderates the Association between Brain Network Impairment and Both Motor Function and Cognition in Progressive Multiple Sclerosis.” Journal of Neurology 270, no. 10 (October 2023): 4876–88. https://doi.org/10.1007/s00415-023-11806-y.
Tilsley, Penelope, Isanbert Arun Strohmeyer, Inga Heinrich, Friederike Rosenthal, Stefan Patra, Karl Heinz Schulz, Sina C. Rosenkranz, et al. “Correction to: Physical Fitness Moderates the Association between Brain Network Impairment and Both Motor Function and Cognition in Progressive Multiple Sclerosis.” Journal of Neurology 270, no. 10 (October 2023): 4889. https://doi.org/10.1007/s00415-023-11874-0.
El Mendili, Mohamed Mounir, Annie Verschueren, Jean-Philippe Ranjeva, Maxime Guye, Shahram Attarian, Wafaa Zaaraoui, and Aude-Marie Grapperon. “Association between Brain and Upper Cervical Spinal Cord Atrophy Assessed by MRI and Disease Aggressiveness in Amyotrophic Lateral Sclerosis.” Neuroradiology 65, no. 9 (September 1, 2023): 1395–1403. https://doi.org/10.1007/s00234-023-03191-0.
Demortiere, Sarah, Adil Maarouf, Audrey Rico, Clemence Boutiere, Frederic Hilezian, Pierre Durozard, Jean Pelletier, and Bertrand Audoin. “Disease Evolution in Women With Highly Active MS Who Suspended Natalizumab During Pregnancy vs Rituximab/Ocrelizumab Before Conception.” Neurology(R) Neuroimmunology & Neuroinflammation 10, no. 5 (September 2023): e200161. https://doi.org/10.1212/NXI.0000000000200161.
Claverie, Roxane, Marine Perriguey, Audrey Rico, Clemence Boutiere, Sarah Demortiere, Pierre Durozard, Frederic Hilezian, et al. “Efficacy of Rituximab Outlasts B-Cell Repopulation in Multiple Sclerosis: Time to Rethink Dosing?” Neurology(R) Neuroimmunology & Neuroinflammation 10, no. 5 (September 2023): e200152. https://doi.org/10.1212/NXI.0000000000200152.
Testud, B., N. Fabiani, S. Demortière, S. Mchinda, N. L. Medina, J. Pelletier, M. Guye, B. Audoin, J. P. Stellmann, and V. Callot. “Contribution of the MP2RAGE 7T Sequence in MS Lesions of the Cervical Spinal Cord.” AJNR. American Journal of Neuroradiology 44, no. 9 (September 2023): 1101–7. https://doi.org/10.3174/ajnr.A7964.
Soustelle, Lucas, Thomas Troalen, Andreea Hertanu, Jean-Philippe Ranjeva, Maxime Guye, Gopal Varma, David C. Alsop, Guillaume Duhamel, and Olivier M. Girard. “Quantitative Magnetization Transfer MRI Unbiased by On-Resonance Saturation and Dipolar Order Contributions.” Magnetic Resonance in Medicine 90, no. 3 (September 2023): 875–93. https://doi.org/10.1002/mrm.29678.
Heim, Xavier, Anne Michele Hubert, Issam Raouak, Anthony Charles Nzepa, Jean-Louis Mege, Emilien Delmont, Shahram Attarian, et al. “Validation of ELISA Assays for the Calculation of FLC Indices for the Diagnosis of Intrathecal Immunoglobulin Synthesis.” Clinical Chemistry and Laboratory Medicine (CCLM) 61, no. 9 (August 1, 2023): 1623–29. https://doi.org/10.1515/cclm-2022-0602.
Lee, Hyo M, Seok-Jun Hong, Ravnoor Gill, Benoit Caldairou, Irene Wang, Jian-guo Zhang, Francesco Deleo, et al. “Multimodal Mapping of Regional Brain Vulnerability to Focal Cortical Dysplasia.” Brain 146, no. 8 (August 1, 2023): 3404–15. https://doi.org/10.1093/brain/awad060.