Central Nervous System

Mission statement

The main objective of the INPaC team is to develop innovative and quantitative pre-clinical and clinical MR methods at high and ultra-high magnetic fields, as well as image analysis techniques, in order to improve in vivo the physiological and pathophysiological characterization of both brain and spinal cord.

Preclinical studies of CNS pathological models help refine, reject, or generate hypotheses regarding the mechanistic basis of diseases by providing detailed structural, functional, and metabolic phenotypes/information associated with pathology.

Clinical MR methods developed by researchers and engineers are driven by clinical questions brought by the clinicians of the team specialized in Multiple Sclerosis, Epilepsy and Spinal Cord Injury. Researches focus on the different ways to characterize the anatomical, microstructural, hemodynamic, metabolic, ionic and functional alterations of the Human CNS.

The INPac team also provides through collaborations an academic platform based on the tools developed for the main topics adapted to characterize other CNS diseases (AD, ALS, Stroke, Parkinson, Schizophrenia, Spinal Cord Injury (LIA iLab-Spine) …).

Research Topics


Wilson, Sarah, Floriane Calocer, Fabien Rollot, Mathieu Fauvernier, Laurent Remontet, Laure Tron, Sandra Vukusic, et al. “Effects of Socioeconomic Status on Excess Mortality in Patients with Multiple Sclerosis in France: A Retrospective Observational Cohort Study.” The Lancet Regional Health. Europe 24 (January 2023): 100542. https://doi.org/10.1016/j.lanepe.2022.100542.
Levraut, Michael, Sabine Laurent-Chabalier, Xavier Ayrignac, Kévin Bigaut, Manon Rival, Sanae Squalli, Hélène Zéphir, et al. “Kappa Free Light Chain Biomarkers Are Efficient for the Diagnosis of Multiple Sclerosis: A Large Multicenter Cohort Study.” Neurology(R) Neuroimmunology & Neuroinflammation 10, no. 1 (January 2023): e200049. https://doi.org/10.1212/NXI.0000000000200049.
Hertanu, Andreea, Lucas Soustelle, Julie Buron, Julie Le Priellec, Myriam Cayre, Arnaud Le Troter, Valentin H. Prevost, et al. “Inhomogeneous Magnetization Transfer (IhMT) Imaging in the Acute Cuprizone Mouse Model of Demyelination/Remyelination.” NeuroImage, December 1, 2022, 119785. https://doi.org/10.1016/j.neuroimage.2022.119785.
Grimaldi, Stephan, Alexandre Eusebio, Romain Carron, Jean-Marie Regis, Lionel Velly, Jean-Philippe Azulay, and Tatiana Witjas. “Deep Brain Stimulation-Withdrawal Syndrome in Parkinson’s Disease: Risk Factors and Pathophysiological Hypotheses of a Life-Threatening Emergency.” Neuromodulation: Journal of the International Neuromodulation Society, November 4, 2022, S1094-7159(22)01285-5. https://doi.org/10.1016/j.neurom.2022.09.008.
Vukusic, Sandra, Clarisse Carra-Dalliere, Jonathan Ciron, Elisabeth Maillart, Laure Michel, Emmanuelle Leray, Anne-Marie Guennoc, et al. “Pregnancy and Multiple Sclerosis: 2022 Recommendations from the French Multiple Sclerosis Society.” Multiple Sclerosis (Houndmills, Basingstoke, England), November 1, 2022, 13524585221129472. https://doi.org/10.1177/13524585221129472.
Taso, Manuel, Fanny Munsch, Olivier M. Girard, Guillaume Duhamel, David C. Alsop, and Gopal Varma. “Fast-Spin-Echo versus Rapid Gradient-Echo for 3D Magnetization-Prepared Acquisitions: Application to Inhomogeneous Magnetization Transfer.” Magnetic Resonance in Medicine, October 28, 2022. https://doi.org/10.1002/mrm.29461.
Roos, Izanne, Charles Malpas, Emmanuelle Leray, Romain Casey, Dana Horakova, Eva Kubala Havrdova, Marc Debouverie, et al. “Disease Reactivation After Cessation of Disease-Modifying Therapy in Patients With Relapsing-Remitting Multiple Sclerosis.” Neurology 99, no. 17 (October 25, 2022): e1926–44. https://doi.org/10.1212/WNL.0000000000201029.
Has Silemek, Arzu Ceylan, Guido Nolte, Jana Pöttgen, Andreas K. Engel, Christoph Heesen, Stefan M. Gold, and Jan-Patrick Stellmann. “Topological Reorganization of Brain Network Might Contribute to the Resilience of Cognitive Functioning in Mildly Disabled Relapsing Remitting Multiple Sclerosis.” Journal of Neuroscience Research, October 19, 2022. https://doi.org/10.1002/jnr.25135.
Azilinon, Mikhael, Julia Makhalova, Wafaa Zaaraoui, Samuel Medina Villalon, Patrick Viout, Tangi Roussel, Mohamed M. El Mendili, et al. “Combining Sodium MRI, Proton MR Spectroscopic Imaging, and Intracerebral EEG in Epilepsy.” Human Brain Mapping, October 11, 2022. https://doi.org/10.1002/hbm.26102.
Testud, Benoit, Jan-Patrick Stellmann, Nadine Girard, and Jean-Francois Hak. “Tumoral Hemorrhagic Stroke Revealing Carotid Angiosarcoma-Related Cerebral Metastases.” Neurology India 70, no. 5 (October 2022): 2246–48. https://doi.org/10.4103/0028-3886.359227.
Scholly, Julia, Adrien Gras, Maxime Guye, Mathias Bilger, Maria Paola Valenti Hirsch, Edouard Hirsch, Alexander Timofeev, Pierre Vidailhet, Christian G. Bénar, and Fabrice Bartolomei. “Connectivity Alterations in Emotional and Cognitive Networks During a Manic State Induced by Direct Electrical Stimulation.” Brain Topography, September 7, 2022. https://doi.org/10.1007/s10548-022-00913-0.
Kai, Jason, Ali R. Khan, Roy Am Haast, and Jonathan C. Lau. “Mapping the Subcortical Connectome Using in Vivo Diffusion MRI: Feasibility and Reliability.” NeuroImage, August 9, 2022, 119553. https://doi.org/10.1016/j.neuroimage.2022.119553.
Alsop, David C., Ece Ercan, Olivier M. Girard, Alex L. Mackay, Carl A. Michal, Gopal Varma, Elena Vinogradov, and Guillaume Duhamel. “Inhomogeneous Magnetization Transfer (IhMT) Imaging: Concepts and Directions for Further Development.” NMR in Biomedicine, August 2, 2022. https://doi.org/10.1002/nbm.4808.
Forodighasemabadi, Arash, Guillaume Baucher, Lucas Soustelle, Thomas Troalen, Olivier M. Girard, Maxime Guye, Jean-Baptiste Grisoli, Jean-Philippe Ranjeva, Guillaume Duhamel, and Virginie Callot. “Spinal Cord and Brain Tissue Impairments as Long-Term Effects of Rugby Practice? An Exploratory Study Based on T1 and IhMTsat Measures.” NeuroImage. Clinical 35 (July 23, 2022): 103124. https://doi.org/10.1016/j.nicl.2022.103124.
Poullet, Zélia, Julie Pique, Adil Maarouf, Clemence Boutiere, Audrey Rico, Sarah Demortiere, Pierre Durozard, et al. “Pure Relapsing Short Myelitis: Part of the Multiple Sclerosis Spectrum or New Entity?” Neurology(R) Neuroimmunology & Neuroinflammation 9, no. 4 (July 2022): e1167. https://doi.org/10.1212/NXI.0000000000001167.
Maarouf, Adil, Bertrand Audoin, Soraya Gherib, Mohamed Mounir El Mendili, Patrick Viout, Fanelly Pariollaud, Clémence Boutière, et al. “Grey-Matter Sodium Concentration as an Individual Marker of Multiple Sclerosis Severity.” Multiple Sclerosis (Houndmills, Basingstoke, England), June 20, 2022, 13524585221102588. https://doi.org/10.1177/13524585221102587.
Hak, Jean-Francois, Gregoire Boulouis, Basile Kerleroux, Sandro Benichi, Sarah Stricker, Florent Gariel, Lorenzo Garzelli, et al. “Pediatric Brain Arteriovenous Malformation Recurrence: A Cohort Study, Systematic Review and Meta-Analysis.” Journal of NeuroInterventional Surgery 14, no. 6 (June 1, 2022): 611–17. https://doi.org/10.1136/neurintsurg-2021-017777.
Januel, Edouard, Jérôme De Seze, Patrick Vermersch, Elisabeth Maillart, Bertrand Bourre, Julie Pique, Xavier Moisset, et al. “Post-Vaccine COVID-19 in Patients with Multiple Sclerosis or Neuromyelitis Optica.” Multiple Sclerosis Journal 28, no. 7 (June 1, 2022): 1155–59. https://doi.org/10.1177/13524585211049737.
Drai, Maxime, Benoit Testud, Gilles Brun, Jean-François Hak, Didier Scavarda, Nadine Girard, and Jan-Patrick Stellmann. “Borrowing Strength from Adults: Transferability of AI Algorithms for Paediatric Brain and Tumour Segmentation.” European Journal of Radiology 151 (June 2022): 110291. https://doi.org/10.1016/j.ejrad.2022.110291.
Lefort, Mathilde, Sandra Vukusic, Romain Casey, Gilles Edan, Emmanuelle Leray, and OFSEP investigators. “Disability Progression in Multiple Sclerosis Patients Using Early First-Line Treatments.” European Journal of Neurology 29, no. 9 (May 26, 2022): 2761–71. https://doi.org/10.1111/ene.15422.
Makhalova, Julia, Samuel Medina Villalon, Huifang Wang, Bernard Giusiano, Marmaduke Woodman, Christian Bénar, Maxime Guye, Viktor Jirsa, and Fabrice Bartolomei. “Virtual Epileptic Patient Brain Modeling: Relationships with Seizure Onset and Surgical Outcome.” Epilepsia, May 23, 2022. https://doi.org/10.1111/epi.17310.
Thiery, Louis, Xavier Carle, Benoit Testud, Gregoire Boulouis, Paul Habert, Farouk Tradi, Anthony Reyre, et al. “Distal Cerebral Vasospasm Treatment Following Aneurysmal Subarachnoid Hemorrhage Using the Comaneci Device: Technical Feasibility and Single-Center Preliminary Results.” Journal of Neurointerventional Surgery, May 18, 2022, neurintsurg-2022-018699. https://doi.org/10.1136/neurintsurg-2022-018699.
Heesen, C., M. Magyari, J. P. Stellmann, C. Lederer, G. Giovannoni, A. Scalfari, and M. Daumer. “The Sylvia Lawry Centre for Multiple Sclerosis Research (SLCMSR)--Critical Review Facing the 20 Anniversary.” Multiple Sclerosis and Related Disorders 63 (May 16, 2022): 103885. https://doi.org/10.1016/j.msard.2022.103885.
Horowitz, T., S. Grimaldi, J.-P. Azulay, and E. Guedj. “Molecular Imaging in Parkinsonism: The Essential for Clinical Practice and Future Perspectives.” Revue Neurologique, May 5, 2022, S0035-3787(22)00547-1. https://doi.org/10.1016/j.neurol.2022.03.002.
Daoud, Maëva, Ricardo Salvador, Nada El Youssef, Alexane Fierain, Elodie Garnier, Maria Chiara Biagi, Samuel Medina Villalon, et al. “Stereo-EEG Based Personalized Multichannel Transcranial Direct Current Stimulation in Drug-Resistant Epilepsy.” Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology 137 (March 11, 2022): 142–51. https://doi.org/10.1016/j.clinph.2022.02.023.
Demuth, Stanislas, Maxime Guillaume, Bertrand Bourre, Jonathan Ciron, Hélène Zephir, Yoann Sirejacob, Anne Kerbrat, et al. “Treatment Regimens for Neuromyelitis Optica Spectrum Disorder Attacks: A Retrospective Cohort Study.” Journal of Neuroinflammation 19, no. 1 (March 2, 2022): 62. https://doi.org/10.1186/s12974-022-02420-2.
Rollot, Fabien, Justine Couturier, Romain Casey, Sandrine Wiertlewski, Marc Debouverie, Jean Pelletier, Jérôme De Sèze, et al. “Comparative Effectiveness of Natalizumab Versus Anti-CD20 in Highly Active Relapsing-Remitting Multiple Sclerosis After Fingolimod Withdrawal.” Neurotherapeutics: The Journal of the American Society for Experimental NeuroTherapeutics 19, no. 2 (March 2022): 476–90. https://doi.org/10.1007/s13311-022-01202-1.
Roussel, Tangi, Yann Le Fur, Maxime Guye, Patrick Viout, Jean-Philippe Ranjeva, and Virginie Callot. “Respiratory-Triggered Quantitative MR Spectroscopy of the Human Cervical Spinal Cord at 7 T.” Magnetic Resonance in Medicine, February 18, 2022. https://doi.org/10.1002/mrm.29182.
Testud, Benoit, Clara Delacour, Ahmed Ali El Ahmadi, Gilles Brun, Nadine Girard, Guillaume Duhamel, Christoph Heesen, et al. “Brain Grey Matter Perfusion in Primary Progressive Multiple Sclerosis: Mild Decrease over Years and Regional Associations with Cognition and Hand Function.” European Journal of Neurology, February 15, 2022. https://doi.org/10.1111/ene.15289.
Florent, C., M. Beylerian, K. Mairot, L. Dambricourt, N. André, T. David, N. Girard, F. Audic, and D. Denis. “Facteurs pronostiques des gliomes des voies optiques associés à la neurofibromatose de type 1 chez les enfants.” Journal Français d’Ophtalmologie 45, no. 2 (February 1, 2022): 173–84. https://doi.org/10.1016/j.jfo.2021.08.012.
Sip, Viktor, Maxime Guye, Fabrice Bartolomei, and Viktor Jirsa. “Computational Modeling of Seizure Spread on a Cortical Surface.” Journal of Computational Neuroscience 50, no. 1 (February 1, 2022): 17–31. https://doi.org/10.1007/s10827-021-00802-8.
Tardieu, Marion, Najat Salameh, Line Souris, David Rousseau, Laurène Jourdain, Hanadi Skeif, François Prévot, et al. “Magnetic Resonance Elastography with Guided Pressure Waves.” NMR in Biomedicine, January 27, 2022, e4701. https://doi.org/10.1002/nbm.4701.
Hümmert, Martin W., Louisa M. Schöppe, Judith Bellmann-Strobl, Nadja Siebert, Friedemann Paul, Ankelien Duchow, Hannah Pellkofer, et al. “Costs and Health-Related Quality of Life in Patients With NMO Spectrum Disorders and MOG-Antibody-Associated Disease: CHANCENMO Study.” Neurology, January 26, 2022, 10.1212/WNL.0000000000200052. https://doi.org/10.1212/WNL.0000000000200052.
Klomjai, Wanalee, Alain Giron, Mohamed Mounir El Mendili, Claire Aymard, Pascale Pradat-Diehl, Nicolas Roche, Rose Katz, Eléonore Bayen, and Alexandra Lackmy-Vallee. “Anodal TDCS of Contralesional Hemisphere Modulates Ipsilateral Control of Spinal Motor Networks Targeting the Paretic Arm Post-Stroke.” Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology 136 (January 20, 2022): 1–12. https://doi.org/10.1016/j.clinph.2021.12.016.
Perriguey, Marine, Adil Maarouf, Jan-Patrick Stellmann, Audrey Rico, Clemence Boutiere, Sarah Demortiere, Pierre Durozard, Jean Pelletier, and Bertrand Audoin. “Hypogammaglobulinemia and Infections in Patients With Multiple Sclerosis Treated With Rituximab.” Neurology(R) Neuroimmunology & Neuroinflammation 9, no. 1 (January 2022): e1115. https://doi.org/10.1212/NXI.0000000000001115.
Ringelstein, Marius, Ilya Ayzenberg, Gero Lindenblatt, Katinka Fischer, Anna Gahlen, Giovanni Novi, Helen Hayward-Könnecke, et al. “Interleukin-6 Receptor Blockade in Treatment-Refractory MOG-IgG-Associated Disease and Neuromyelitis Optica Spectrum Disorders.” Neurology(R) Neuroimmunology & Neuroinflammation 9, no. 1 (January 2022): e1100. https://doi.org/10.1212/NXI.0000000000001100.
Brun, Gilles, Benoit Testud, Olivier M. Girard, Pierre Lehmann, Ludovic de Rochefort, Pierre Besson, Aurélien Massire, et al. “Automatic Segmentation of Deep Grey Nuclei Using a High-Resolution 7T Magnetic Resonance Imaging Atlas—Quantification of T1 Values in Healthy Volunteers.” European Journal of Neuroscience 55, no. 2 (2022): 438–60. https://doi.org/10.1111/ejn.15575.
Petracca, Maria, Gary Cutter, Sirio Cocozza, Leorah Freeman, John Kangarlu, Monica Margoni, Matteo Moro, et al. “Cerebellar Pathology and Disability Worsening in Relapsing-Remitting Multiple Sclerosis: A Retrospective Analysis from the CombiRx Trial.” European Journal of Neurology 29, no. 2 (2022): 515–21. https://doi.org/10.1111/ene.15157.
Soustelle, Lucas, Thomas Troalen, Andreea Hertanu, Samira Mchinda, Jean-Philippe Ranjeva, Maxime Guye, Gopal Varma, David C. Alsop, Guillaume Duhamel, and Olivier M. Girard. “A Strategy to Reduce the Sensitivity of Inhomogeneous Magnetization Transfer (IhMT) Imaging to Radiofrequency Transmit Field Variations at 3 T.” Magnetic Resonance in Medicine 87, no. 3 (2022): 1346–59. https://doi.org/10.1002/mrm.29055.
Hertanu, Andreea, Lucas Soustelle, Julie Buron, Julie Le Priellec, Myriam Cayre, Arnaud Le Troter, Gopal Varma, et al. “T1D-Weighted IhMT Imaging – Part II. Investigating the Long- and Short-T1D Components Correlation with Myelin Content. Comparison with R1 and the Macromolecular Proton Fraction.” Magnetic Resonance in Medicine 87, no. 5 (2022): 2329–46. https://doi.org/10.1002/mrm.29140.
Hertanu, Andreea, Lucas Soustelle, Arnaud Le Troter, Julie Buron, Julie Le Priellec, Victor N. D. Carvalho, Myriam Cayre, et al. “T1D-Weighted IhMT Imaging – Part I. Isolation of Long- and Short-T1D Components by T1D-Filtering.” Magnetic Resonance in Medicine 87, no. 5 (2022): 2313–28. https://doi.org/10.1002/mrm.29139.
Aloi, Davide, Roya Jalali, Penelope Tilsley, R. Chris Miall, and Davinia Fernández-Espejo. “TDCS Modulates Effective Connectivity during Motor Command Following; a Potential Therapeutic Target for Disorders of Consciousness.” NeuroImage 247 (December 5, 2021): 118781. https://doi.org/10.1016/j.neuroimage.2021.118781.
Forodighasemabadi, Arash, Henitsoa Rasoanandrianina, Mohamed Mounir El Mendili, Maxime Guye, and Virginie Callot. “An Optimized MP2RAGE Sequence for Studying Both Brain and Cervical Spinal Cord in a Single Acquisition at 3T.” Magnetic Resonance Imaging 84 (December 1, 2021): 18–26. https://doi.org/10.1016/j.mri.2021.08.011.
Kerleroux, Basile, Joseph Benzakoun, Kévin Janot, Cyril Dargazanli, Dimitri Daly Eraya, Wagih Ben Hassen, François Zhu, et al. “Relevance of Brain Regions’ Eloquence Assessment in Patients With a Large Ischemic Core Treated With Mechanical Thrombectomy.” Neurology 97, no. 20 (November 16, 2021): e1975–85. https://doi.org/10.1212/WNL.0000000000012863.
Makhalova, Julia, Arnaud Le Troter, Sandrine Aubert-Conil, Bernard Giusiano, Aileen McGonigal, Agnès Trebuchon, Romain Carron, et al. “Epileptogenic Networks in Drug-Resistant Epilepsy with Amygdala Enlargement: Assessment with Stereo-EEG and 7 T MRI.” Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology 133 (November 10, 2021): 94–103. https://doi.org/10.1016/j.clinph.2021.10.012.
Péran, P., A.S. Salabert, T. Dondaine, X. Leclerc, H. Gros-Dagnac, J.-P. Ranjeva, R. Lopes, et al. “Functional Connectivity and Cognitive Changes after Donepezil Treatment in Healthy Participants.” Psychopharmacology 238, no. 11 (November 1, 2021): 3071–82. https://doi.org/10.1007/s00213-021-05923-7.
Gill, Ravnoor Singh, Hyo-Min Lee, Benoit Caldairou, Seok-Jun Hong, Carmen Barba, Francesco Deleo, Ludovico D’Incerti, et al. “Multicenter Validation of a Deep Learning Detection Algorithm for Focal Cortical Dysplasia.” Neurology 97, no. 16 (October 19, 2021): e1571–82. https://doi.org/10.1212/WNL.0000000000012698.
Medina, Nilser J. Laines, Charley Gros, Julien Cohen-Adad, Virginie Callot, and Arnaud Le Troter. “2D Multi-Class Model for Gray and White Matter Segmentation of the Cervical Spinal Cord at 7T.” arXiv, October 13, 2021. https://doi.org/10.48550/arXiv.2110.06516.
Cohen-Adad, Julien, Eva Alonso-Ortiz, Mihael Abramovic, Carina Arneitz, Nicole Atcheson, Laura Barlow, Robert L. Barry, et al. “Generic Acquisition Protocol for Quantitative MRI of the Spinal Cord.” Nature Protocols 16, no. 10 (October 2021): 4611–32. https://doi.org/10.1038/s41596-021-00588-0.
Rico, Audrey, Laetitia Ninove, Adil Maarouf, Clémence Boutiere, Pierre Durozard, Sarah Demortiere, Paola Mariela Saba Villarroel, et al. “Determining the Best Window for BNT162b2 MRNA Vaccination for SARS-CoV-2 in Patients with Multiple Sclerosis Receiving Anti-CD20 Therapy.” Multiple Sclerosis Journal - Experimental, Translational and Clinical 7, no. 4 (October 2021): 20552173211062144. https://doi.org/10.1177/20552173211062142.