Central Nervous System


Mission statement

The main objective of the CNS team is to develop innovative and quantitative pre-clinical and clinical MR methods at high and ultra-high magnetic fields, as well as image analysis techniques, in order to improve in vivo the physiological and pathophysiological characterization of both brain and spinal cord.

Preclinical studies of CNS pathological models help refine, reject, or generate hypotheses regarding the mechanistic basis of diseases by providing detailed structural, functional, and metabolic phenotypes/information associated with pathology.

Clinical MR methods developed by researchers and engineers are driven by clinical questions brought by the clinicians of the team specialized in Multiple Sclerosis, Epilepsy and Spinal Cord Injury. Researches focus on the different ways to characterize the anatomical, microstructural, hemodynamic, metabolic, ionic and functional alterations of the Human CNS.

The CNS team also provides through collaborations an academic platform based on the tools developed for the main topics adapted to characterize other CNS diseases (AD, ALS, Stroke, Parkinson, Schizophrenia, Spinal Cord Injury (LIA iLab-Spine) …).

Research Topics

Brain Imaging
PHENIQS - Physics and digital technologies for quantitative imaging of the central nervous system
Preclinical Imaging
Spinal Cord Imaging
Translational Neuroscience and Clinical Applications

Publications

Makhalova, Julia, Tanguy Madec, Samuel Medina Villalon, Aude Jegou, Stanislas Lagarde, Romain Carron, Didier Scavarda, Elodie Garnier, Christian G. Bénar, and Fabrice Bartolomei. “The Role of Quantitative Markers in Surgical Prognostication after Stereoelectroencephalography.” Annals of Clinical and Translational Neurology, September 21, 2023. https://doi.org/10.1002/acn3.51900.
Kümpfel, Tania, Katrin Giglhuber, Orhan Aktas, Ilya Ayzenberg, Judith Bellmann-Strobl, Vivien Häußler, Joachim Havla, et al. “Update on the Diagnosis and Treatment of Neuromyelitis Optica Spectrum Disorders (NMOSD) - Revised Recommendations of the Neuromyelitis Optica Study Group (NEMOS). Part II: Attack Therapy and Long-Term Management.” Journal of Neurology, September 7, 2023. https://doi.org/10.1007/s00415-023-11910-z.
Demortiere, Sarah, Adil Maarouf, Audrey Rico, Clemence Boutiere, Frederic Hilezian, Pierre Durozard, Jean Pelletier, and Bertrand Audoin. “Disease Evolution in Women With Highly Active MS Who Suspended Natalizumab During Pregnancy vs Rituximab/Ocrelizumab Before Conception.” Neurology(R) Neuroimmunology & Neuroinflammation 10, no. 5 (September 2023): e200161. https://doi.org/10.1212/NXI.0000000000200161.
Claverie, Roxane, Marine Perriguey, Audrey Rico, Clemence Boutiere, Sarah Demortiere, Pierre Durozard, Frederic Hilezian, et al. “Efficacy of Rituximab Outlasts B-Cell Repopulation in Multiple Sclerosis: Time to Rethink Dosing?” Neurology(R) Neuroimmunology & Neuroinflammation 10, no. 5 (September 2023): e200152. https://doi.org/10.1212/NXI.0000000000200152.
Testud, Benoit, Aurélie Manchon, Jan-Patrick Stellmann, and Jean-Francois Hak. “The White Matter Spreading MRI Pattern of Listeria Monocytogenes.” Neurology, August 21, 2023, 10.1212/WNL.0000000000207803. https://doi.org/10.1212/WNL.0000000000207803.
Perles-Barbacaru, Adriana T. “Editorial for ‘Feasibility of Multiparametric Perfusion Assessment in Diabetic Foot Ulcer Using Intravoxel Incoherent Motion and Blood Oxygenation-Level Dependent MRI.’” Journal of Magnetic Resonance Imaging: JMRI, August 19, 2023. https://doi.org/10.1002/jmri.28953.
Testud, B., N. Fabiani, S. Demortière, S. Mchinda, N. L. Medina, J. Pelletier, M. Guye, B. Audoin, J. P. Stellmann, and V. Callot. “Contribution of the MP2RAGE 7T Sequence in MS Lesions of the Cervical Spinal Cord.” AJNR. American Journal of Neuroradiology, August 10, 2023. https://doi.org/10.3174/ajnr.A7964.
El Mendili, Mohamed Mounir, Annie Verschueren, Jean-Philippe Ranjeva, Maxime Guye, Shahram Attarian, Wafaa Zaaraoui, and Aude-Marie Grapperon. “Association between Brain and Upper Cervical Spinal Cord Atrophy Assessed by MRI and Disease Aggressiveness in Amyotrophic Lateral Sclerosis.” Neuroradiology, July 17, 2023. https://doi.org/10.1007/s00234-023-03191-0.
Haast, Roy A. M., Benoit Testud, Julia Makhalova, Hugo Dary, Alexandre Cabane, Arnaud Le Troter, Jean-Philippe Ranjeva, Fabrice Bartolomei, and Maxime Guye. “Multi-Scale Structural Alterations of the Thalamus and Basal Ganglia in Focal Epilepsy Using 7T MRI.” Human Brain Mapping, July 12, 2023. https://doi.org/10.1002/hbm.26414.
Rosenkranz, Sina C., Lilija Gutmann, Arzu Ceylan Has Silemek, Michael Dorr, Vivien Häußler, Margareta Lüpke, Andrea Mönch, et al. “Visual Function Resists Early Neurodegeneration in the Visual System in Primary Progressive Multiple Sclerosis.” Journal of Neurology, Neurosurgery, and Psychiatry, July 11, 2023, jnnp-2023-331183. https://doi.org/10.1136/jnnp-2023-331183.
Brocard, Guillaume, Romain Casey, Nathalie Dufay, Romain Marignier, Laure Michel, Michael Hisbergues, Xavier Ayrignac, et al. “The Biological Sample Collection of the OFSEP French MS Registry: An Essential Tool Dedicated to Researchers.” Multiple Sclerosis and Related Disorders 77 (July 7, 2023): 104872. https://doi.org/10.1016/j.msard.2023.104872.
Tilsley, Penelope, Isanbert Arun Strohmeyer, Inga Heinrich, Friederike Rosenthal, Stefan Patra, Karl Heinz Schulz, Sina C. Rosenkranz, et al. “Physical Fitness Moderates the Association between Brain Network Impairment and Both Motor Function and Cognition in Progressive Multiple Sclerosis.” Journal of Neurology, June 21, 2023. https://doi.org/10.1007/s00415-023-11806-y.
Destruel, Aurelien, Franck Mauconduit, Aurélien Massire, Redha Abdeddaim, Maxime Guye, Vincent Gras, and Virginie Callot. “Optimized Interferometric Encoding of Presaturated TurboFLASH B1 Mapping for Parallel Transmission MRI at 7 T: Preliminary Application for Quantitative T1 Mapping in the Spinal Cord.” Magnetic Resonance in Medicine, May 29, 2023. https://doi.org/10.1002/mrm.29708.
Soustelle, Lucas, Thomas Troalen, Andreea Hertanu, Jean-Philippe Ranjeva, Maxime Guye, Gopal Varma, David C. Alsop, Guillaume Duhamel, and Olivier M. Girard. “Quantitative Magnetization Transfer MRI Unbiased by On-Resonance Saturation and Dipolar Order Contributions.” Magnetic Resonance in Medicine, May 8, 2023. https://doi.org/10.1002/mrm.29678.
Jarius, Sven, Orhan Aktas, Ilya Ayzenberg, Judith Bellmann-Strobl, Achim Berthele, Katrin Giglhuber, Vivien Häußler, et al. “Update on the Diagnosis and Treatment of Neuromyelits Optica Spectrum Disorders (NMOSD) - Revised Recommendations of the Neuromyelitis Optica Study Group (NEMOS). Part I: Diagnosis and Differential Diagnosis.” Journal of Neurology, April 6, 2023. https://doi.org/10.1007/s00415-023-11634-0.
Heim, Xavier, Anne Michele Hubert, Issam Raouak, Anthony Charles Nzepa, Jean-Louis Mege, Emilien Delmont, Shahram Attarian, et al. “Validation of ELISA Assays for the Calculation of FLC Indices for the Diagnosis of Intrathecal Immunoglobulin Synthesis.” Clinical Chemistry and Laboratory Medicine, April 6, 2023. https://doi.org/10.1515/cclm-2022-0602.
Thiery, Louis, Xavier Carle, Benoit Testud, Gregoire Boulouis, Paul Habert, Farouk Tradi, Anthony Reyre, et al. “Distal Cerebral Vasospasm Treatment Following Aneurysmal Subarachnoid Hemorrhage Using the Comaneci Device: Technical Feasibility and Single-Center Preliminary Results.” Journal of NeuroInterventional Surgery 15, no. 4 (April 1, 2023): 325–29. https://doi.org/10.1136/neurintsurg-2022-018699.
Rode, Julie, Julie Pique, Adil Maarouf, Xavier Ayrignac, Bertrand Bourre, Jonathan Ciron, Mikael Cohen, et al. “Time to Steroids Impacts Visual Outcome of Optic Neuritis in MOGAD.” Journal of Neurology, Neurosurgery & Psychiatry 94, no. 4 (April 1, 2023): 309–13. https://doi.org/10.1136/jnnp-2022-330360.
Dollomaja, Borana, Julia Makhalova, Huifang Wang, Fabrice Bartolomei, Viktor Jirsa, and Christophe Bernard. “Personalized Whole Brain Modeling of Status Epilepticus.” Epilepsy & Behavior: E&B 142 (March 30, 2023): 109175. https://doi.org/10.1016/j.yebeh.2023.109175.
Gavoille, Antoine, Fabien Rollot, Romain Casey, Marc Debouverie, Emmanuelle Le Page, Jonathan Ciron, Jerome De Seze, et al. “Investigating the Long-Term Effect of Pregnancy on the Course of Multiple Sclerosis Using Causal Inference.” Neurology 100, no. 12 (March 21, 2023): e1296–1308. https://doi.org/10.1212/WNL.0000000000206774.
Hümmert, Martin W., Franziska Bütow, Daria Tkachenko, Ilya Ayzenberg, Thivya Pakeerathan, Kerstin Hellwig, Luisa Klotz, et al. “Effects of the COVID-19 Pandemic on Patients With NMO Spectrum Disorders and MOG-Antibody-Associated Diseases: COPANMO(G)-Study.” Neurology(R) Neuroimmunology & Neuroinflammation 10, no. 2 (March 2023): e200082. https://doi.org/10.1212/NXI.0000000000200082.
Lee, Hyo M, Seok-Jun Hong, Ravnoor Gill, Benoit Caldairou, Irene Wang, Jian-guo Zhang, Francesco Deleo, et al. “Multimodal Mapping of Regional Brain Vulnerability to Focal Cortical Dysplasia.” Brain, February 28, 2023, awad060. https://doi.org/10.1093/brain/awad060.
Ridley, Ben, Filomena Morsillo, Wafaa Zaaraoui, and Francesco Nonino. “Variability by Region and Method in Human Brain Sodium Concentrations Estimated by 23Na Magnetic Resonance Imaging: A Meta-Analysis.” Scientific Reports 13, no. 1 (February 24, 2023): 3222. https://doi.org/10.1038/s41598-023-30363-y.
Chen, John J., Eoin P. Flanagan, Sean J. Pittock, Nicole Caroline Stern, Nanthaya Tisavipat, M. Tariq Bhatti, Kevin D. Chodnicki, et al. “Visual Outcomes Following Plasma Exchange for Optic Neuritis: An International Multicenter Retrospective Analysis of 395 Optic Neuritis Attacks.” American Journal of Ophthalmology, February 21, 2023, S0002-9394(23)00066-1. https://doi.org/10.1016/j.ajo.2023.02.013.
Hümmert, Martin W., Carlotta Stern, Friedemann Paul, Ankelien Duchow, Judith Bellmann-Strobl, Ilya Ayzenberg, Carolin Schwake, et al. “Cognition in Patients with Neuromyelitis Optica Spectrum Disorders: A Prospective Multicentre Study of 217 Patients (CogniNMO-Study).” Multiple Sclerosis (Houndmills, Basingstoke, England), February 14, 2023, 13524585231151212. https://doi.org/10.1177/13524585231151212.
Sabathé, Camille, Romain Casey, Sandra Vukusic, Emmanuelle Leray, Guillaume Mathey, Jérôme De Sèze, Jonathan Ciron, et al. “Improving the Decision to Switch from First- to Second-Line Therapy in Multiple Sclerosis: A Dynamic Scoring System.” Multiple Sclerosis Journal 29, no. 2 (February 1, 2023): 236–47. https://doi.org/10.1177/13524585221139156.
Grimaldi, Stephan, Alexandre Eusebio, Romain Carron, Jean-Marie Regis, Lionel Velly, Jean-Philippe Azulay, and Tatiana Witjas. “Deep Brain Stimulation–Withdrawal Syndrome in Parkinson’s Disease: Risk Factors and Pathophysiological Hypotheses of a Life-Threatening Emergency.” Neuromodulation 26, no. 2 (February 1, 2023): 424–34. https://doi.org/10.1016/j.neurom.2022.09.008.
Wang, Huifang E., Marmaduke Woodman, Paul Triebkorn, Jean-Didier Lemarechal, Jayant Jha, Borana Dollomaja, Anirudh Nihalani Vattikonda, et al. “Delineating Epileptogenic Networks Using Brain Imaging Data and Personalized Modeling in Drug-Resistant Epilepsy.” Science Translational Medicine 15, no. 680 (January 25, 2023): eabp8982. https://doi.org/10.1126/scitranslmed.abp8982.
Hertanu, Andreea, Lucas Soustelle, Julie Buron, Julie Le Priellec, Myriam Cayre, Arnaud Le Troter, Valentin H. Prevost, et al. “Inhomogeneous Magnetization Transfer (IhMT) Imaging in the Acute Cuprizone Mouse Model of Demyelination/Remyelination.” NeuroImage 265 (January 1, 2023): 119785. https://doi.org/10.1016/j.neuroimage.2022.119785.
Vukusic, Sandra, Romain Marignier, Jonathan Ciron, Bertrand Bourre, Mikael Cohen, Romain Deschamps, Maxime Guillaume, et al. “Pregnancy and Neuromyelitis Optica Spectrum Disorders: 2022 Recommendations from the French Multiple Sclerosis Society.” Multiple Sclerosis Journal 29, no. 1 (January 1, 2023): 37–51. https://doi.org/10.1177/13524585221130934.
Vukusic, Sandra, Clarisse Carra-Dalliere, Jonathan Ciron, Elisabeth Maillart, Laure Michel, Emmanuelle Leray, Anne-Marie Guennoc, et al. “Pregnancy and Multiple Sclerosis: 2022 Recommendations from the French Multiple Sclerosis Society.” Multiple Sclerosis Journal 29, no. 1 (January 1, 2023): 11–36. https://doi.org/10.1177/13524585221129472.
Wilson, Sarah, Floriane Calocer, Fabien Rollot, Mathieu Fauvernier, Laurent Remontet, Laure Tron, Sandra Vukusic, et al. “Effects of Socioeconomic Status on Excess Mortality in Patients with Multiple Sclerosis in France: A Retrospective Observational Cohort Study.” The Lancet Regional Health. Europe 24 (January 2023): 100542. https://doi.org/10.1016/j.lanepe.2022.100542.
Levraut, Michael, Sabine Laurent-Chabalier, Xavier Ayrignac, Kévin Bigaut, Manon Rival, Sanae Squalli, Hélène Zéphir, et al. “Kappa Free Light Chain Biomarkers Are Efficient for the Diagnosis of Multiple Sclerosis: A Large Multicenter Cohort Study.” Neurology(R) Neuroimmunology & Neuroinflammation 10, no. 1 (January 2023): e200049. https://doi.org/10.1212/NXI.0000000000200049.
Comino Garcia-Munoz, Alicia, Yasser Alemán-Gómez, Rafael Toledano, Claudia Poch, Irene García-Morales, Ángel Aledo-Serrano, Antonio Gil-Nagel, and Pablo Campo. “Morphometric and Microstructural Characteristics of Hippocampal Subfields in Mesial Temporal Lobe Epilepsy and Their Correlates with Mnemonic Discrimination.” Frontiers in Neurology 14 (2023): 1096873. https://doi.org/10.3389/fneur.2023.1096873.
Alsop, David C., Ece Ercan, Olivier M. Girard, Alex L. Mackay, Carl A. Michal, Gopal Varma, Elena Vinogradov, and Guillaume Duhamel. “Inhomogeneous Magnetization Transfer Imaging: Concepts and Directions for Further Development.” NMR in Biomedicine 36, no. 6 (2023): e4808. https://doi.org/10.1002/nbm.4808.
Taso, Manuel, Fanny Munsch, Olivier M. Girard, Guillaume Duhamel, David C. Alsop, and Gopal Varma. “Fast-Spin-Echo versus Rapid Gradient-Echo for 3D Magnetization-Prepared Acquisitions: Application to Inhomogeneous Magnetization Transfer.” Magnetic Resonance in Medicine 89, no. 2 (2023): 550–64. https://doi.org/10.1002/mrm.29461.
Thaler, Christian, Jan Sedlacik, Nils D. Forkert, Jan-Patrick Stellmann, Gerhard Schön, Jens Fiehler, and Susanne Gellißen. “Effect of Geometric Distortion Correction on Thickness and Volume Measurements of Cortical Parcellations in 3D T1w Gradient Echo Sequences.” PloS One 18, no. 4 (2023): e0284440. https://doi.org/10.1371/journal.pone.0284440.
Eydoux, Raphaëlle, Emmanuelle Lesieur, Julie Blanc, Nadine Girard, Claude D’ercole, Sabine Sigaudy, Kathia Chaumoitre, and Florence Bretelle. “Relevance of Fetal Brain Magnetic Resonance Imaging Compared to Ultrasound for Detecting Cerebral Anomalies in Fetuses with Cleft Lip and/or Palate: A Cohort Study.” Fetal Diagnosis and Therapy 50, no. 1 (2023): 37–46. https://doi.org/10.1159/000528906.
Azilinon, Mikhael, Julia Makhalova, Wafaa Zaaraoui, Samuel Medina Villalon, Patrick Viout, Tangi Roussel, Mohamed M. El Mendili, et al. “Combining Sodium MRI, Proton MR Spectroscopic Imaging, and Intracerebral EEG in Epilepsy.” Human Brain Mapping 44, no. 2 (2023): 825–40. https://doi.org/10.1002/hbm.26102.
Has Silemek, Arzu Ceylan, Guido Nolte, Jana Pöttgen, Andreas K. Engel, Christoph Heesen, Stefan M. Gold, and Jan-Patrick Stellmann. “Topological Reorganization of Brain Network Might Contribute to the Resilience of Cognitive Functioning in Mildly Disabled Relapsing Remitting Multiple Sclerosis.” Journal of Neuroscience Research 101, no. 1 (2023): 143–61. https://doi.org/10.1002/jnr.25135.
Aita, Jean-François, Thibault Agripnidis, Benoit Testud, Pierre-Antoine Barral, Alexis Jacquier, Anthony Reyre, Ammar Alnuaimi, et al. “Stenting in Brain Hemodynamic Injury of Carotid Origin Caused by Type A Aortic Dissection: Local Experience and Systematic Literature Review.” Journal of Personalized Medicine 13, no. 1 (December 27, 2022): 58. https://doi.org/10.3390/jpm13010058.
Bolton, Thomas A. W., Dimitri Van De Ville, Jean Régis, Tatiana Witjas, Nadine Girard, Marc Levivier, and Constantin Tuleasca. “Exploring the Heterogeneous Morphometric Data in Essential Tremor with Probabilistic Modelling.” NeuroImage. Clinical 37 (December 6, 2022): 103283. https://doi.org/10.1016/j.nicl.2022.103283.
Kai, Jason, Ali R Khan, Roy AM Haast, and Jonathan C Lau. “Mapping the Subcortical Connectome Using in Vivo Diffusion MRI: Feasibility and Reliability.” NeuroImage 262 (November 15, 2022): 119553. https://doi.org/10.1016/j.neuroimage.2022.119553.
Scholly, Julia, Adrien Gras, Maxime Guye, Mathias Bilger, Maria Paola Valenti Hirsch, Edouard Hirsch, Alexander Timofeev, Pierre Vidailhet, Christian G. Bénar, and Fabrice Bartolomei. “Connectivity Alterations in Emotional and Cognitive Networks During a Manic State Induced by Direct Electrical Stimulation.” Brain Topography 35, no. 5 (November 1, 2022): 627–35. https://doi.org/10.1007/s10548-022-00913-0.
Roos, Izanne, Charles Malpas, Emmanuelle Leray, Romain Casey, Dana Horakova, Eva Kubala Havrdova, Marc Debouverie, et al. “Disease Reactivation After Cessation of Disease-Modifying Therapy in Patients With Relapsing-Remitting Multiple Sclerosis.” Neurology 99, no. 17 (October 25, 2022): e1926–44. https://doi.org/10.1212/WNL.0000000000201029.
Maarouf, Adil, Bertrand Audoin, Soraya Gherib, Mohamed Mounir El Mendili, Patrick Viout, Fanelly Pariollaud, Clémence Boutière, et al. “Grey-Matter Sodium Concentration as an Individual Marker of Multiple Sclerosis Severity.” Multiple Sclerosis Journal 28, no. 12 (October 1, 2022): 1903–12. https://doi.org/10.1177/13524585221102587.
Testud, Benoit, Jan-Patrick Stellmann, Nadine Girard, and Jean-Francois Hak. “Tumoral Hemorrhagic Stroke Revealing Carotid Angiosarcoma-Related Cerebral Metastases.” Neurology India 70, no. 5 (October 2022): 2246–48. https://doi.org/10.4103/0028-3886.359227.
Forodighasemabadi, Arash, Guillaume Baucher, Lucas Soustelle, Thomas Troalen, Olivier M. Girard, Maxime Guye, Jean-Baptiste Grisoli, Jean-Philippe Ranjeva, Guillaume Duhamel, and Virginie Callot. “Spinal Cord and Brain Tissue Impairments as Long-Term Effects of Rugby Practice? An Exploratory Study Based on T1 and IhMTsat Measures.” NeuroImage. Clinical 35 (July 23, 2022): 103124. https://doi.org/10.1016/j.nicl.2022.103124.
Poullet, Zélia, Julie Pique, Adil Maarouf, Clemence Boutiere, Audrey Rico, Sarah Demortiere, Pierre Durozard, et al. “Pure Relapsing Short Myelitis: Part of the Multiple Sclerosis Spectrum or New Entity?” Neurology(R) Neuroimmunology & Neuroinflammation 9, no. 4 (July 2022): e1167. https://doi.org/10.1212/NXI.0000000000001167.
Bolton, Thomas A. W., Dimitri Van De Ville, Jean Régis, Tatiana Witjas, Nadine Girard, Marc Levivier, and Constantin Tuleasca. “Morphometric Features of Drug-Resistant Essential Tremor and Recovery after Stereotactic Radiosurgical Thalamotomy.” Network Neuroscience (Cambridge, Mass.) 6, no. 3 (July 2022): 850–69. https://doi.org/10.1162/netn_a_00253.