Central Nervous System

Mission statement

The main objective of the INPaC team is to develop innovative and quantitative pre-clinical and clinical MR methods at high and ultra-high magnetic fields, as well as image analysis techniques, in order to improve in vivo the physiological and pathophysiological characterization of both brain and spinal cord.

Preclinical studies of CNS pathological models help refine, reject, or generate hypotheses regarding the mechanistic basis of diseases by providing detailed structural, functional, and metabolic phenotypes/information associated with pathology.

Clinical MR methods developed by researchers and engineers are driven by clinical questions brought by the clinicians of the team specialized in Multiple Sclerosis, Epilepsy and Spinal Cord Injury. Researches focus on the different ways to characterize the anatomical, microstructural, hemodynamic, metabolic, ionic and functional alterations of the Human CNS.

The INPac team also provides through collaborations an academic platform based on the tools developed for the main topics adapted to characterize other CNS diseases (AD, ALS, Stroke, Parkinson, Schizophrenia, Spinal Cord Injury (LIA iLab-Spine) …).

Research Topics


Daoud, Maëva, Ricardo Salvador, Nada El Youssef, Alexane Fierain, Elodie Garnier, Maria Chiara Biagi, Samuel Medina Villalon, et al. “Stereo-EEG Based Personalized Multichannel Transcranial Direct Current Stimulation in Drug-Resistant Epilepsy.” Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology 137 (March 11, 2022): 142–51. https://doi.org/10.1016/j.clinph.2022.02.023.
Demuth, Stanislas, Maxime Guillaume, Bertrand Bourre, Jonathan Ciron, Hélène Zephir, Yoann Sirejacob, Anne Kerbrat, et al. “Treatment Regimens for Neuromyelitis Optica Spectrum Disorder Attacks: A Retrospective Cohort Study.” Journal of Neuroinflammation 19, no. 1 (March 2, 2022): 62. https://doi.org/10.1186/s12974-022-02420-2.
Roussel, Tangi, Yann Le Fur, Maxime Guye, Patrick Viout, Jean-Philippe Ranjeva, and Virginie Callot. “Respiratory-Triggered Quantitative MR Spectroscopy of the Human Cervical Spinal Cord at 7 T.” Magnetic Resonance in Medicine, February 18, 2022. https://doi.org/10.1002/mrm.29182.
Testud, Benoit, Clara Delacour, Ahmed Ali El Ahmadi, Gilles Brun, Nadine Girard, Guillaume Duhamel, Christoph Heesen, et al. “Brain Grey Matter Perfusion in Primary Progressive Multiple Sclerosis: Mild Decrease over Years and Regional Associations with Cognition and Hand Function.” European Journal of Neurology, February 15, 2022. https://doi.org/10.1111/ene.15289.
Tardieu, Marion, Najat Salameh, Line Souris, David Rousseau, Laurène Jourdain, Hanadi Skeif, François Prévot, et al. “Magnetic Resonance Elastography with Guided Pressure Waves.” NMR in Biomedicine, January 27, 2022, e4701. https://doi.org/10.1002/nbm.4701.
Hümmert, Martin W., Louisa M. Schöppe, Judith Bellmann-Strobl, Nadja Siebert, Friedemann Paul, Ankelien Duchow, Hannah Pellkofer, et al. “Costs and Health-Related Quality of Life in Patients With NMO Spectrum Disorders and MOG-Antibody-Associated Disease: CHANCENMO Study.” Neurology, January 26, 2022, 10.1212/WNL.0000000000200052. https://doi.org/10.1212/WNL.0000000000200052.
Klomjai, Wanalee, Alain Giron, Mohamed Mounir El Mendili, Claire Aymard, Pascale Pradat-Diehl, Nicolas Roche, Rose Katz, Eléonore Bayen, and Alexandra Lackmy-Vallee. “Anodal TDCS of Contralesional Hemisphere Modulates Ipsilateral Control of Spinal Motor Networks Targeting the Paretic Arm Post-Stroke.” Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology 136 (January 20, 2022): 1–12. https://doi.org/10.1016/j.clinph.2021.12.016.
Hertanu, Andreea, Lucas Soustelle, Arnaud Le Troter, Julie Buron, Julie Le Priellec, Victor N. D. Carvalho, Myriam Cayre, et al. “T1D -Weighted IhMT Imaging - Part I. Isolation of Long- and Short-T1D Components by T1D -Filtering.” Magnetic Resonance in Medicine, January 17, 2022. https://doi.org/10.1002/mrm.29139.
Hertanu, Andreea, Lucas Soustelle, Julie Buron, Julie Le Priellec, Myriam Cayre, Arnaud Le Troter, Gopal Varma, et al. “T1D -Weighted IhMT Imaging - Part II. Investigating the Long- and Short-T1D Components Correlation with Myelin Content. Comparison with R1 and the Macromolecular Proton Fraction.” Magnetic Resonance in Medicine, January 9, 2022. https://doi.org/10.1002/mrm.29140.
Perriguey, Marine, Adil Maarouf, Jan-Patrick Stellmann, Audrey Rico, Clemence Boutiere, Sarah Demortiere, Pierre Durozard, Jean Pelletier, and Bertrand Audoin. “Hypogammaglobulinemia and Infections in Patients With Multiple Sclerosis Treated With Rituximab.” Neurology(R) Neuroimmunology & Neuroinflammation 9, no. 1 (January 2022): e1115. https://doi.org/10.1212/NXI.0000000000001115.
Ringelstein, Marius, Ilya Ayzenberg, Gero Lindenblatt, Katinka Fischer, Anna Gahlen, Giovanni Novi, Helen Hayward-Könnecke, et al. “Interleukin-6 Receptor Blockade in Treatment-Refractory MOG-IgG-Associated Disease and Neuromyelitis Optica Spectrum Disorders.” Neurology(R) Neuroimmunology & Neuroinflammation 9, no. 1 (January 2022): e1100. https://doi.org/10.1212/NXI.0000000000001100.
Brun, Gilles, Benoit Testud, Olivier M. Girard, Pierre Lehmann, Ludovic de Rochefort, Pierre Besson, Aurélien Massire, et al. “Automatic Segmentation of Deep Grey Nuclei Using a High-Resolution 7T MRI Atlas - Quantification of T1 Values in Healthy Volunteers.” The European Journal of Neuroscience, December 22, 2021. https://doi.org/10.1111/ejn.15575.
Januel, Edouard, Jérôme De Seze, Patrick Vermersch, Elisabeth Maillart, Bertrand Bourre, Julie Pique, Xavier Moisset, et al. “Post-Vaccine COVID-19 in Patients with Multiple Sclerosis or Neuromyelitis Optica.” Multiple Sclerosis (Houndmills, Basingstoke, England), December 21, 2021, 13524585211049736. https://doi.org/10.1177/13524585211049737.
Aloi, Davide, Roya Jalali, Penelope Tilsley, R. Chris Miall, and Davinia Fernández-Espejo. “TDCS Modulates Effective Connectivity during Motor Command Following; a Potential Therapeutic Target for Disorders of Consciousness.” NeuroImage 247 (December 5, 2021): 118781. https://doi.org/10.1016/j.neuroimage.2021.118781.
Kerleroux, Basile, Joseph Benzakoun, Kévin Janot, Cyril Dargazanli, Dimitri Daly Eraya, Wagih Ben Hassen, François Zhu, et al. “Relevance of Brain Regions’ Eloquence Assessment in Patients With a Large Ischemic Core Treated With Mechanical Thrombectomy.” Neurology 97, no. 20 (November 16, 2021): e1975–85. https://doi.org/10.1212/WNL.0000000000012863.
Soustelle, Lucas, Thomas Troalen, Andreea Hertanu, Samira Mchinda, Jean-Philippe Ranjeva, Maxime Guye, Gopal Varma, David C. Alsop, Guillaume Duhamel, and Olivier M. Girard. “A Strategy to Reduce the Sensitivity of Inhomogeneous Magnetization Transfer (IhMT) Imaging to Radiofrequency Transmit Field Variations at 3 T.” Magnetic Resonance in Medicine, November 15, 2021. https://doi.org/10.1002/mrm.29055.
Makhalova, Julia, Arnaud Le Troter, Sandrine Aubert-Conil, Bernard Giusiano, Aileen McGonigal, Agnès Trebuchon, Romain Carron, et al. “Epileptogenic Networks in Drug-Resistant Epilepsy with Amygdala Enlargement: Assessment with Stereo-EEG and 7 T MRI.” Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology 133 (November 10, 2021): 94–103. https://doi.org/10.1016/j.clinph.2021.10.012.
Petracca, Maria, Gary Cutter, Sirio Cocozza, Leorah Freeman, John Kangarlu, Monica Margoni, Matteo Moro, et al. “Cerebellar Pathology and Disability Worsening in Relapsing-Remitting Multiple Sclerosis: A Retrospective Analysis from the CombiRx Trial.” European Journal of Neurology, October 25, 2021. https://doi.org/10.1111/ene.15157.
Sip, Viktor, Maxime Guye, Fabrice Bartolomei, and Viktor Jirsa. “Computational Modeling of Seizure Spread on a Cortical Surface.” Journal of Computational Neuroscience, October 23, 2021. https://doi.org/10.1007/s10827-021-00802-8.
Hak, Jean-Francois, Gregoire Boulouis, Basile Kerleroux, Sandro Benichi, Sarah Stricker, Florent Gariel, Lorenzo Garzelli, et al. “Pediatric Brain Arteriovenous Malformation Recurrence: A Cohort Study, Systematic Review and Meta-Analysis.” Journal of NeuroInterventional Surgery, September 28, 2021, neurintsurg-2021-017777. https://doi.org/10.1136/neurintsurg-2021-017777.
Gill, Ravnoor Singh, Hyo-Min Lee, Benoit Caldairou, Seok-Jun Hong, Carmen Barba, Francesco Deleo, Ludovico D’Incerti, et al. “Multicenter Validation of a Deep Learning Detection Algorithm for Focal Cortical Dysplasia.” Neurology, September 14, 2021, 10.1212/WNL.0000000000012698. https://doi.org/10.1212/WNL.0000000000012698.
Forodighasemabadi, Arash, Henitsoa Rasoanandrianina, Mohamed Mounir El Mendili, Maxime Guye, and Virginie Callot. “An Optimized MP2RAGE Sequence for Studying Both Brain and Cervical Spinal Cord in a Single Acquisition at 3T.” Magnetic Resonance Imaging, September 10, 2021, S0730-725X(21)00141-7. https://doi.org/10.1016/j.mri.2021.08.011.
Giovannelli, Jonathan, Jonathan Ciron, Mikael Cohen, Ho-Jin Kim, Su-Hyun Kim, Jan-Patrik Stellmann, Ingo Kleiter, et al. “A Meta-Analysis Comparing First-Line Immunosuppressants in Neuromyelitis Optica.” Annals of Clinical and Translational Neurology, September 10, 2021. https://doi.org/10.1002/acn3.51451.
Frison, Eric, Cecile Proust-Lima, Jean-Francois Mangin, Marie-Odile Habert, Stephanie Bombois, Pierre-Jean Ousset, Florence Pasquier, et al. “Diabetes Mellitus and Cognition: Pathway Analysis in the MEMENTO Cohort.” Neurology 97, no. 8 (August 24, 2021): e836–48. https://doi.org/10.1212/WNL.0000000000012440.
Droby, Amgad, Mohamed Mounir El Mendili, Nir Giladi, Jeffery M. Hausdorff, Inbal Maidan, and Anat Mirelman. “Gait and Cognitive Abnormalities Are Associated with Regional Cerebellar Atrophy in Elderly Fallers - A Pilot Study.” Gait & Posture 90 (August 18, 2021): 99–105. https://doi.org/10.1016/j.gaitpost.2021.08.012.
Cohen-Adad, Julien, Eva Alonso-Ortiz, Mihael Abramovic, Carina Arneitz, Nicole Atcheson, Laura Barlow, Robert L. Barry, et al. “Open-Access Quantitative MRI Data of the Spinal Cord and Reproducibility across Participants, Sites and Manufacturers.” Scientific Data 8, no. 1 (August 16, 2021): 219. https://doi.org/10.1038/s41597-021-00941-8.
Cohen-Adad, Julien, Eva Alonso-Ortiz, Mihael Abramovic, Carina Arneitz, Nicole Atcheson, Laura Barlow, Robert L. Barry, et al. “Generic Acquisition Protocol for Quantitative MRI of the Spinal Cord.” Nature Protocols, August 16, 2021. https://doi.org/10.1038/s41596-021-00588-0.
Péran, P., A. S. Salabert, T. Dondaine, X. Leclerc, H. Gros-Dagnac, J.-P. Ranjeva, R. Lopes, et al. “Functional Connectivity and Cognitive Changes after Donepezil Treatment in Healthy Participants.” Psychopharmacology, August 9, 2021. https://doi.org/10.1007/s00213-021-05923-7.
Has Silemek, Arzu C., Jean-Philippe Ranjeva, Bertrand Audoin, Christoph Heesen, Stefan M. Gold, Simone Kühn, Martin Weygandt, and Jan-Patrick Stellmann. “Delayed Access to Conscious Processing in Multiple Sclerosis: Reduced Cortical Activation and Impaired Structural Connectivity.” Human Brain Mapping 42, no. 11 (August 1, 2021): 3379–95. https://doi.org/10.1002/hbm.25440.
Tanoh, Ian-Christopher, Elisabeth Maillart, Pierre Labauge, Mikael Cohen, Adil Maarouf, Sandra Vukusic, Cécile Donzé, et al. “MSCopilot: New Smartphone-Based Digital Biomarkers Correlate with Expanded Disability Status Scale Scores in People with Multiple Sclerosis.” Multiple Sclerosis and Related Disorders 55 (July 23, 2021): 103164. https://doi.org/10.1016/j.msard.2021.103164.
Hashemi, Meysam, Anirudh N. Vattikonda, Viktor Sip, Sandra Diaz-Pier, Alexander Peyser, Huifang Wang, Maxime Guye, Fabrice Bartolomei, Marmaduke M. Woodman, and Viktor K. Jirsa. “On the Influence of Prior Information Evaluated by Fully Bayesian Criteria in a Personalized Whole-Brain Model of Epilepsy Spread.” PLoS Computational Biology 17, no. 7 (July 14, 2021): e1009129. https://doi.org/10.1371/journal.pcbi.1009129.
Fissolo, Nicolás, Beatrice Pignolet, Jordi Rio, Patrick Vermersch, Aurélie Ruet, Jerome deSèze, Pierre Labauge, et al. “Serum Neurofilament Levels and PML Risk in Patients With Multiple Sclerosis Treated With Natalizumab.” Neurology(R) Neuroimmunology & Neuroinflammation 8, no. 4 (July 2021): e1003. https://doi.org/10.1212/NXI.0000000000001003.
Corgier-Pattberg, Anaïs, Marie Beylerian, Stephanie Clave, Mathilde Cailliez, Benoit Testud, and Beatrice Desnous. “Threatening Blindness in a Child With Typical Hemolytic Uremic Syndrome.” Pediatric Neurology 122 (June 25, 2021): 35–37. https://doi.org/10.1016/j.pediatrneurol.2021.06.008.
Callot, Virginie, Aurélien Massire, Maxime Guye, Shahram Attarian, and Annie Verschueren. “Visualization of Gray Matter Atrophy and Anterior Corticospinal Tract Signal Hyperintensity in Amyotrophic Lateral Sclerosis Using 7T MRI.” Neurology 96, no. 23 (June 8, 2021): 1094–95. https://doi.org/10.1212/WNL.0000000000012072.
Hilezian, Frédéric, Adil Maarouf, Clemence Boutiere, Audrey Rico, Sarah Demortiere, Philippe Kerschen, Thomas Sene, et al. “TNF-α Inhibitors Used as Steroid-Sparing Maintenance Monotherapy in Parenchymal CNS Sarcoidosis.” Journal of Neurology, Neurosurgery, and Psychiatry, June 8, 2021. https://doi.org/10.1136/jnnp-2020-325665.
Häußler, Vivien, Friederike Ufer, Jana Pöttgen, Christine Wolschke, Manuel A. Friese, Nicolaus Kröger, Christoph Heesen, and Jan-Patrick Stellmann. “AHSCT Is Superior to Alemtuzumab in Maintaining NEDA and Improving Cognition in Multiple Sclerosis.” Annals of Clinical and Translational Neurology 8, no. 6 (June 2021): 1269–78. https://doi.org/10.1002/acn3.51366.
Baucher, G., H. Rasoanandrianina, S. Levy, L. Pini, L. Troude, P.-H. Roche, and V. Callot. “T1 Mapping for Microstructural Assessment of the Cervical Spinal Cord in the Evaluation of Patients with Degenerative Cervical Myelopathy.” AJNR. American Journal of Neuroradiology, May 13, 2021. https://doi.org/10.3174/ajnr.A7157.
Sourdon, Joevin, Tangi Roussel, Claire Costes, Patrick Viout, Maxime Guye, Jean-Philippe Ranjeva, Monique Bernard, Frank Kober, and Stanislas Rapacchi. “Comparison of Single-Voxel 1H-Cardiovascular Magnetic Resonance Spectroscopy Techniques for in Vivo Measurement of Myocardial Creatine and Triglycerides at 3T.” Journal of Cardiovascular Magnetic Resonance: Official Journal of the Society for Cardiovascular Magnetic Resonance 23, no. 1 (May 13, 2021): 53. https://doi.org/10.1186/s12968-021-00748-x.
Ameli, Roxana, Charles R. G. Guttmann, Juan Carlos Prieto, Fabien Rollot, Miklos Palotai, Sandra Vukusic, Romain Marignier, et al. “Aquaporin 4 Distribution in the Brain and Its Relevance for the Radiological Appearance of Neuromyelitis Optica Spectrum Disease.” Journal of Neuroradiology = Journal De Neuroradiologie 48, no. 3 (May 2021): 170–75. https://doi.org/10.1016/j.neurad.2019.03.015.
Ayzenberg, Ilya, Daniel Richter, Eugenia Henke, Susanna Asseyer, Friedemann Paul, Corinna Trebst, Martin W. Hümmert, et al. “Pain, Depression, and Quality of Life in Neuromyelitis Optica Spectrum Disorder: A Cross-Sectional Study of 166 AQP4 Antibody-Seropositive Patients.” Neurology(R) Neuroimmunology & Neuroinflammation 8, no. 3 (May 2021): e985. https://doi.org/10.1212/NXI.0000000000000985.
Perez, Thomas, Audrey Rico, Clémence Boutière, Adil Maarouf, Marjorie Roudot, Stéphane Honoré, Jean Pelletier, Pierre Bertault-Peres, and Bertrand Audoin. “Comparison of Rituximab Originator (MabThera®) to Biosimilar (Truxima®) in Patients with Multiple Sclerosis.” Multiple Sclerosis (Houndmills, Basingstoke, England) 27, no. 4 (April 2021): 585–92. https://doi.org/10.1177/1352458520912170.
Payoux, Pierre, and Jean-Philippe Ranjeva. “Contributions of PET and MRI Imaging in the Evaluation of CNS Drugs in Human Neurodegenerative Diseases.” Therapie 76, no. 2 (April 2021): 121–26. https://doi.org/10.1016/j.therap.2020.12.008.
Tuleasca, Constantin, Tatiana Witjas, Marc Levivier, Nadine Girard, Axelle Cretol, Nicolas Levy, Jean-Philippe Thiran, Eric Guedj, Dimitri Van de Ville, and Jean Régis. “The Brain Connectome after Gamma Knife Radiosurgery of the Ventro-Intermediate Nucleus for Tremor: Marseille-Lausanne Radiobiology Study Protocol.” Stereotactic and Functional Neurosurgery, March 8, 2021, 1–6. https://doi.org/10.1159/000514066.
Lévy, Simon, Pierre-Hugues Roche, Maxime Guye, and Virginie Callot. “Feasibility of Human Spinal Cord Perfusion Mapping Using Dynamic Susceptibility Contrast Imaging at 7T: Preliminary Results and Identified Guidelines.” Magnetic Resonance in Medicine 85, no. 3 (March 2021): 1183–94. https://doi.org/10.1002/mrm.28559.
Chard, Declan T., Adnan A. S. Alahmadi, Bertrand Audoin, Thalis Charalambous, Christian Enzinger, Hanneke E. Hulst, Maria A. Rocca, et al. “Mind the Gap: From Neurons to Networks to Outcomes in Multiple Sclerosis.” Nature Reviews. Neurology 17, no. 3 (March 2021): 173–84. https://doi.org/10.1038/s41582-020-00439-8.
Sip, Viktor, Julia Scholly, Maxime Guye, Fabrice Bartolomei, and Viktor Jirsa. “Evidence for Spreading Seizure as a Cause of Theta-Alpha Activity Electrographic Pattern in Stereo-EEG Seizure Recordings.” PLoS Computational Biology 17, no. 2 (February 26, 2021): e1008731. https://doi.org/10.1371/journal.pcbi.1008731.
Stellmann, Jan-Patrick, Nadine Wanke, Adil Maarouf, Susanne Gellißen, Christoph Heesen, Bertrand Audoin, Stefan M. Gold, Wafaa Zaaraoui, and Jana Poettgen. “Cognitive Performance Shows Domain Specific Associations with Regional Cortical Thickness in Multiple Sclerosis.” NeuroImage. Clinical 30 (February 24, 2021): 102606. https://doi.org/10.1016/j.nicl.2021.102606.
Opheim, Giske, Anja van der Kolk, Karin Markenroth Bloch, Albert J. Colon, Kathryn A. Davis, Thomas R. Henry, Jacobus F. A. Jansen, et al. “7T Epilepsy Task Force Consensus Recommendations on the Use of 7T MRI in Clinical Practice.” Neurology 96, no. 7 (February 16, 2021): 327–41. https://doi.org/10.1212/WNL.0000000000011413.
Krause, Nicole, Karin Riemann-Lorenz, Tanja Steffen, Anne Christin Rahn, Jana Pöttgen, Jan-Patrick Stellmann, Sascha Köpke, et al. “Study Protocol for a Randomised Controlled Trial of a Web-Based Behavioural Lifestyle Programme for EmPOWERment in Early Multiple Sclerosis (POWER@MS1).” BMJ Open 11, no. 2 (February 16, 2021): e041720. https://doi.org/10.1136/bmjopen-2020-041720.
Massire, Aurélien, Charlotte Seiler, Thomas Troalen, Olivier M. Girard, Pierre Lehmann, Gilles Brun, Axel Bartoli, et al. “T1-Based Synthetic Magnetic Resonance Contrasts Improve Multiple Sclerosis and Focal Epilepsy Imaging at 7 T.” Investigative Radiology 56, no. 2 (February 1, 2021): 127–33. https://doi.org/10.1097/RLI.0000000000000718.