Musculoskeletal System



Mission statement

The MSK group is conducting research related to Muscle energetics, Quantitative muscle MRI and Quantitative MSK MRI. A transversal project is devoted to muscle segmentation.

Regarding Muscle energetics, experiments are conducted in both humans and animal models. The corresponding topics are related to standardisation of results and protocols, metabolic effects of training, impact of muscle pathologies, metabolic control, muscle fatigue and functional effects of electrostimulation.

Quantitative investigation of muscle using MRI is mainly performed in collaboration with the Neurology Department of Prof. Attarian (Timone Hospital). The aim is to assess the validity of outcome measures for the follow-up of natural history of rare disorders affecting muscle and also to assess the efficiency of therapeutic strategy.

The MSK program is devoted to the quantitative and functional analysis of cartilage in both rheumatoid and osteo-arthritis using quantitative MRI approaches. Another topic is dedicated to microstructural analysis of bone at ultra high-field.

The transversal project related to segmentation mainly addresses the issue of an optimal supervised segmentation of individual muscles using a variety of approaches i.e. multi-atlas- based, registration-based, artificial intelligence-based…

Through national and international collaborations, we develop a multidiscplinary approach of muscle and joint function using different non invasive techniques and investigating a variety of physiological and pathophysiological conditions.

The muscle Group at CRMBM is a multidisciplinary team composed of biochemists, physiologists, physicists and clinicians.


Research Topics


Publications

Heskamp, Linda, Augustin Ogier, David Bendahan, and Arend Heerschap. “Whole-Muscle Fat Analysis Identifies Distal Muscle End as Disease Initiation Site in Facioscapulohumeral Muscular Dystrophy.” Communications Medicine 2, no. 1 (December 1, 2022): 155. https://doi.org/10.1038/s43856-022-00217-1.
Soldati, Enrico, Flavy Roseren, Daphne Guenoun, Lucia Mancini, Emilio Catelli, Silvia Prati, Giorgia Sciutto, et al. “Multiscale Femoral Neck Imaging and Multimodal Trabeculae Quality Characterization in an Osteoporotic Bone Sample.” Materials (Basel, Switzerland) 15, no. 22 (November 14, 2022): 8048. https://doi.org/10.3390/ma15228048.
Cadour, Farah, Jennifer Cautela, Stanislas Rapacchi, Arthur Varoquaux, Paul Habert, François Arnaud, Alexis Jacquier, et al. “Cardiac MRI Features and Prognostic Value in Immune Checkpoint                    Inhibitor–Induced Myocarditis.” Radiology 303, no. 3 (June 2022): 512–21. https://doi.org/10.1148/radiol.211765.
Boutray, Marie de, Mélanie Pons, Nicolas Graillon, Cyrille Chossegros, Anthony Reyre, Christophe Chagnaud, and Arthur Varoquaux. “Stensen’s Duct Stenosis Balloon Dilatation: Long-Term Evaluation of Clinical Outcomes and Quality of Life Impacts.” Otolaryngology–Head and Neck Surgery, May 3, 2022, 01945998221097636. https://doi.org/10.1177/01945998221097636.
Jourdan, Arthur, Stanislas Rapacchi, Maxime Guye, David Bendahan, Catherine Masson, and Thierry Bège. “Dynamic-MRI Quantification of Abdominal Wall Motion and Deformation during Breathing and Muscular Contraction.” Computer Methods and Programs in Biomedicine 217 (January 29, 2022): 106667. https://doi.org/10.1016/j.cmpb.2022.106667.
Michel, Constance P., Laurent A. Messonnier, Benoit Giannesini, Benjamin Chatel, Christophe Vilmen, Yann Le Fur, and David Bendahan. “Effects of Hydroxyurea on Skeletal Muscle Energetics and Function in a Mildly Anemic Mouse Model.” Frontiers in Physiology 13 (2022): 915640. https://doi.org/10.3389/fphys.2022.915640.
Shpringer, Guy, David Bendahan, and Noam Ben-Eliezer. “Accelerated Reconstruction of Dictionary-Based T2 Relaxation Maps Based on Dictionary Compression and Gradient Descent Search Algorithms.” Magnetic Resonance Imaging 87 (December 30, 2021): 56–66. https://doi.org/10.1016/j.mri.2021.12.006.
Brui, Ekaterina A., Stanislas Rapacchi, David Bendahan, and Anna E. Andreychenko. “Comparative Analysis of SINC-Shaped and SLR Pulses Performance for Contiguous Multi-Slice Fast Spin-Echo Imaging Using Metamaterial-Based MRI.” Magnetic Resonance Materials in Physics, Biology and Medicine 34, no. 6 (December 1, 2021): 929–38. https://doi.org/10.1007/s10334-021-00937-w.
Park, Jae Mo, Sonal Josan, Ralph E. Hurd, James Graham, Peter J. Havel, David Bendahan, Dirk Mayer, Youngran Chung, Daniel M. Spielman, and Thomas Jue. “Hyperpolarized NMR Study of the Impact of Pyruvate Dehydrogenase Kinase Inhibition on the Pyruvate Dehydrogenase and TCA Flux in Type 2 Diabetic Rat Muscle.” Pflügers Archiv - European Journal of Physiology 473, no. 11 (November 1, 2021): 1761–73. https://doi.org/10.1007/s00424-021-02613-3.
Arsovic, Emina, Marion Montava, Nicolas Fakhry, Jean-Pierre Lavieille, Karel Pacak, David Taïeb, and Arthur Varoquaux. “Quantitative Biomarkers Allow the Diagnosis of Head and Neck Paraganglioma on Multiparametric MRI.” European Journal of Radiology 143 (October 2021): 109911. https://doi.org/10.1016/j.ejrad.2021.109911.
Chatel, Benjamin, Sylvie Ducreux, Zeina Harhous, Nadia Bendridi, Isabelle Varlet, Augustin C. Ogier, Monique Bernard, et al. “Impaired Aerobic Capacity and Premature Fatigue Preceding Muscle Weakness in the Skeletal Muscle Tfam-Knockout Mouse Model.” Disease Models & Mechanisms 14, no. 9 (September 15, 2021): dmm048981. https://doi.org/10.1242/dmm.048981.
Soldati, Enrico, Jerome Vicente, Daphne Guenoun, David Bendahan, and Martine Pithioux. “Validation and Optimization of Proximal Femurs Microstructure Analysis Using High Field and Ultra-High Field MRI.” Diagnostics (Basel, Switzerland) 11, no. 9 (September 2, 2021): 1603. https://doi.org/10.3390/diagnostics11091603.
Fournel, Joris, Axel Bartoli, David Bendahan, Maxime Guye, Monique Bernard, Elisa Rauseo, Mohammed Y. Khanji, Steffen E. Petersen, Alexis Jacquier, and Badih Ghattas. “Medical Image Segmentation Automatic Quality Control: A Multi-Dimensional Approach.” Medical Image Analysis 74 (August 12, 2021): 102213. https://doi.org/10.1016/j.media.2021.102213.
Guedj, E., J. Y. Campion, P. Dudouet, E. Kaphan, F. Bregeon, H. Tissot-Dupont, S. Guis, et al. “18F-FDG Brain PET Hypometabolism in Patients with Long COVID.” European Journal of Nuclear Medicine and Molecular Imaging 48, no. 9 (August 2021): 2823–33. https://doi.org/10.1007/s00259-021-05215-4.
Winter, Josine M. de, Charlotte Gineste, Elisa Minardi, Lorenza Brocca, Maira Rossi, Tamara Borsboom, Alan H. Beggs, et al. “Acute and Chronic Tirasemtiv Treatment Improves in Vivo and in Vitro Muscle Performance in Actin-Based Nemaline Myopathy Mice.” Human Molecular Genetics 30, no. 14 (June 26, 2021): 1305–20. https://doi.org/10.1093/hmg/ddab112.
Velier, Mélanie, Stéphane Priet, Romain Appay, Thérèse Atieh, Hubert Lepidi, Gilles Kaplanski, Pierre André Jarrot, et al. “Severe and Irreversible Pancytopenia Associated With SARS-CoV-2 Bone Marrow Infection in a Patient With Waldenstrom Macroglobulinemia.” Clinical Lymphoma, Myeloma & Leukemia 21, no. 6 (June 2021): e503–5. https://doi.org/10.1016/j.clml.2021.01.005.
Soldati, Enrico, Francesca Rossi, Jerome Vicente, Daphne Guenoun, Martine Pithioux, Stefano Iotti, Emil Malucelli, and David Bendahan. “Survey of MRI Usefulness for the Clinical Assessment of Bone Microstructure.” International Journal of Molecular Sciences 22, no. 5 (March 2, 2021): 2509. https://doi.org/10.3390/ijms22052509.
Chatel, Benjamin, Emmanuelle Bernit, Christophe Vilmen, Constance Michel, David Bendahan, and Laurent A. Messonnier. “In Vivo Muscle Function and Energetics in Women with Sickle Cell Anemia or Trait: A 31P-Magnetic Resonance Spectroscopy Study.” Journal of Applied Physiology (Bethesda, Md.: 1985) 130, no. 3 (March 1, 2021): 737–45. https://doi.org/10.1152/japplphysiol.00790.2020.
Molto, Anna, Laure Gossec, Serge Poiraudeau, Pascal Claudepierre, Martin Soubrier, Françoise Fayet, Daniel Wendling, et al. “Evaluation of the Impact of a Nurse-Led Program of Patient Self-Assessment and Self-Management in Axial Spondyloarthritis: Results of a Prospective, Multicentre, Randomized, Controlled Trial (COMEDSPA).” Rheumatology (Oxford, England) 60, no. 2 (February 1, 2021): 888–95. https://doi.org/10.1093/rheumatology/keaa480.
Secondulfo, Laura, Augustin C. Ogier, Jithsa R. Monte, Vincent L. Aengevaeren, David Bendahan, Aart J. Nederveen, Gustav J. Strijkers, and Melissa T. Hooijmans. “Supervised Segmentation Framework for Evaluation of Diffusion Tensor Imaging Indices in Skeletal Muscle.” NMR in Biomedicine 34, no. 1 (January 2021): e4406. https://doi.org/10.1002/nbm.4406.
Vergez, S., N. Fakhry, C. Cartier, T. Kennel, M. Courtade-Saidi, E. Uro-Coste, A. Varoquaux, et al. “Guidelines of the French Society of Otorhinolaryngology–Head and Neck Surgery (SFORL), Part I: Primary Treatment of Pleomorphic Adenoma.” European Annals of Otorhinolaryngology, Head and Neck Diseases 138, no. 4 (2021): 269–74. https://doi.org/10.1016/j.anorl.2020.09.002.
Meyerspeer, Martin, Chris Boesch, Donnie Cameron, Monika Dezortová, Sean C. Forbes, Arend Heerschap, Jeroen A.L. Jeneson, et al. “31P Magnetic Resonance Spectroscopy in Skeletal Muscle: Experts’ Consensus Recommendations.” NMR in Biomedicine 34, no. 5 (2021). https://doi.org/10.1002/nbm.4246.
Soldati, Enrico, Lucas Escoffier, Sophie Gabriel, Augustin C. Ogier, Christophe Chagnaud, Jean P. Mattei, Serge Cammilleri, David Bendahan, and Sandrine Guis. “Assessment of in Vivo Bone Microarchitecture Changes in an Anti-TNFα Treated Psoriatic Arthritic Patient.” PloS One 16, no. 5 (2021): e0251788. https://doi.org/10.1371/journal.pone.0251788.
Jourdan, Arthur, Arnaud Le Troter, Pierre Daude, Stanislas Rapacchi, Catherine Masson, Thierry Bège, and David Bendahan. “Semiautomatic Quantification of Abdominal Wall Muscles Deformations Based on Dynamic MRI Image Registration.” NMR in Biomedicine 34, no. 4 (2021): e4470. https://doi.org/10.1002/nbm.4470.
Baboudjian, Michael, Mehdi Mhatli, Adel Bourouina, Bastien Gondran-Tellier, Vassili Anastay, Lea Perez, Pauline Proye, et al. “Is Minor Surgery Safe during the COVID-19 Pandemic? A Multi-Disciplinary Study.” PloS One 16, no. 5 (2021): e0251122. https://doi.org/10.1371/journal.pone.0251122.
Ogier, Augustin C., Marc-Adrien Hostin, Marc-Emmanuel Bellemare, and David Bendahan. “Overview of MR Image Segmentation Strategies in Neuromuscular Disorders.” Frontiers in Neurology 12 (2021): 625308. https://doi.org/10.3389/fneur.2021.625308.
Arsovic, Emina, Marion Montava, Jean-Pierre Lavieille, Karel Pacak, Arthur Varoquaux, and David Taïeb. “Facial Nerve Canal Paraganglioma.” Clinical Nuclear Medicine 45, no. 12 (December 2020): 982–83. https://doi.org/10.1097/RLU.0000000000003321.
Berg, Ole Kristian, Oh Sung Kwon, Thomas J. Hureau, Heather L. Clifton, Taylor S. Thurston, Yann Le Fur, Eun-Kee Jeong, et al. “Skeletal Muscle Mitochondrial Adaptations to Maximal Strength Training in Older Adults.” The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 75, no. 12 (November 13, 2020): 2269–77. https://doi.org/10.1093/gerona/glaa082.
Pelletier, Laurent, Anne Petiot, Julie Brocard, Benoit Giannesini, Diane Giovannini, Colline Sanchez, Lauriane Travard, et al. “In Vivo RyR1 Reduction in Muscle Triggers a Core-like Myopathy.” Acta Neuropathologica Communications 8, no. 1 (November 11, 2020): 192. https://doi.org/10.1186/s40478-020-01068-4.
Falgarone, Géraldine, Frédéric Pamoukdjian, Johann Cailhol, Audrey Giocanti-Auregan, Sandrine Guis, Guilhem Bousquet, Olivier Bouchaud, and Olivier Seror. “Lung Ultrasound Is a Reliable Diagnostic Technique to Predict Abnormal CT Chest Scan and to Detect Oxygen Requirements in COVID-19 Pneumonia.” Aging 12, no. 20 (October 30, 2020): 19945–53. https://doi.org/10.18632/aging.104150.
Poullain, F., J. C. Mattei, A. Rochwerger, C. Bouvier, C. Chagnaud, P. Champsaur, and T. Le Corroller. “Percutaneous Cryoablation of Osteoblastoma in the Proximal Femur.” Skeletal Radiology 49, no. 9 (September 2020): 1467–71. https://doi.org/10.1007/s00256-020-03413-z.
Laurendon, Thomas, Thomas Radulesco, Justine Mugnier, Mélanie Gérault, Christophe Chagnaud, Ahmed-Ali El Ahmadi, and Arthur Varoquaux. “Bilateral Transient Olfactory Bulb Edema during COVID-19-Related Anosmia.” Neurology 95, no. 5 (August 4, 2020): 224–25. https://doi.org/10.1212/WNL.0000000000009850.
Fortanier, E., A. C. Ogier, E. Delmont, M.-N. Lefebvre, P. Viout, M. Guye, D. Bendahan, and S. Attarian. “Quantitative Assessment of Sciatic Nerve Changes in Charcot-Marie-Tooth Type 1A Patients Using Magnetic Resonance Neurography.” European Journal of Neurology 27, no. 8 (August 2020): 1382–89. https://doi.org/10.1111/ene.14303.
Brui, Ekaterina, Aleksandr Y. Efimtcev, Vladimir A. Fokin, Remi Fernandez, Anatoliy G. Levchuk, Augustin C. Ogier, Alexey A. Samsonov, et al. “Deep Learning-Based Fully Automatic Segmentation of Wrist Cartilage in MR Images.” NMR in Biomedicine 33, no. 8 (August 2020): e4320. https://doi.org/10.1002/nbm.4320.
Molto, Anna, Laure Gossec, Serge Poiraudeau, Pascal Claudepierre, Martin Soubrier, Françoise Fayet, Daniel Wendling, et al. “Evaluation of the Impact of a Nurse-Led Program of Systematic Screening of Comorbidities in Patients with Axial Spondyloarthritis: The Results of the COMEDSPA Prospective, Controlled, One Year Randomized Trial.” Seminars in Arthritis and Rheumatism 50, no. 4 (August 2020): 701–8. https://doi.org/10.1016/j.semarthrit.2020.05.012.
Ogier, Augustin C., Linda Heskamp, Constance P. Michel, Alexandre Fouré, Marc-Emmanuel Bellemare, Arnaud Le Troter, Arend Heerschap, and David Bendahan. “A Novel Segmentation Framework Dedicated to the Follow-up of Fat Infiltration in Individual Muscles of Patients with Neuromuscular Disorders.” Magnetic Resonance in Medicine 83, no. 5 (May 2020): 1825–36. https://doi.org/10.1002/mrm.28030.
Radulesco, Thomas, Lionel Meister, Gilles Bouchet, Arthur Varoquaux, Jérome Giordano, Patrick Dessi, Pierre Perrier, and Justin Michel. “Computational Fluid Dynamics and Septal Deviations-Virtual Surgery Can Predict Post-Surgery Results: A Preliminary Study Including Two Patients.” Clinical Otolaryngology: Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery 45, no. 2 (March 2020): 286–91. https://doi.org/10.1111/coa.13495.
Fouré, Alexandre, Augustin C. Ogier, Maxime Guye, Julien Gondin, and David Bendahan. “Muscle Alterations Induced by Electrostimulation Are Lower at Short Quadriceps Femoris Length.” European Journal of Applied Physiology 120, no. 2 (February 2020): 325–35. https://doi.org/10.1007/s00421-019-04277-5.
Simeoni, Umberto, Clive Osmond, Ricardo Garay, Christophe Buffat, Farid Boubred, Christophe Chagnaud, Elisabeth Jouve, Christine Audebert, Jean-Michel Antoine, and Kent Thornburg. “Leptin and Insulin in Young Adulthood Are Associated with Weight in Infancy.” The Journal of Endocrinology 244, no. 2 (February 2020): 249–59. https://doi.org/10.1530/JOE-18-0538.
Guenoun, D., M. Pithioux, J. -C. Souplet, S. Guis, T. Le Corroller, A. Fouré, V. Pauly, et al. “Assessment of Proximal Femur Microarchitecture Using Ultra-High Field MRI at 7 Tesla.” Diagnostic and Interventional Imaging 101, no. 1 (January 1, 2020): 45–53. https://doi.org/10.1016/j.diii.2019.06.013.
Delmas, Justine, Arthur Varoquaux, Lucas Troude, Florent Salburgo, Jean-Pierre Lavieille, and Marion Montava. “Incidental Effect of Long-Term Tacrolimus Treatment on Sporadic Vestibular Schwannoma Volume Shrinkage and Clinical Improvement.” Otology & Neurotology: Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 41, no. 1 (January 2020): e89–93. https://doi.org/10.1097/MAO.0000000000002428.
Touati, J., G. Rico, P. Habert, M. Gérault, J. Y. Gaubert, C. Chagnaud, and A. Varoquaux. “Prevention of Nosocomial Transmission of SARS-CoV-2 Using Pre-Operative Chest CT: A Monocentric Study during the Outbreak.” The Journal of Hospital Infection 106, no. 1 (2020): 186–88. https://doi.org/10.1016/j.jhin.2020.07.005.
Hurshkainen, Anna, Marc Dubois, Anton Nikulin, Christophe Vilmen, David Bendahan, Stefan Enoch, Stanislav Glybovski, and Redha Abdeddaim. “Radio Frequency Coil for Dual-Nuclei MR Muscle Energetics Investigation Based on Two Capacitively Coupled Periodic Wire Arrays.” IEEE Antennas and Wireless Propagation Letters 19, no. 5 (2020): 721–25. https://doi.org/10.1109/LAWP.2019.2960610.
Ansari, Behnaz, Emmanuelle Salort-Campana, Augustin Ogier, Arnaud Le Troter PhD, Benjamin De Sainte Marie, Maxime Guye, Emilien Delmont, et al. “Quantitative Muscle MRI Study of Patients with Sporadic Inclusion Body Myositis.” Muscle & Nerve 61, no. 4 (2020): 496–503. https://doi.org/10.1002/mus.26813.
Bas, Joachim, Augustin C. Ogier, Arnaud Le Troter, Emilien Delmont, Benjamin Leporq, Lauriane Pini, Maxime Guye, et al. “Fat Fraction Distribution in Lower Limb Muscles of Patients with CMT1A: A Quantitative MRI Study.” Neurology 94, no. 14 (07 2020): e1480–87. https://doi.org/10.1212/WNL.0000000000009013.
Gineste, Charlotte, Augustin C. Ogier, Isabelle Varlet, Zaynab Hourani, Monique Bernard, Henk Granzier, David Bendahan, and Julien Gondin. “In Vivo Characterization of Skeletal Muscle Function in Nebulin-Deficient Mice.” Muscle & Nerve 61, no. 3 (2020): 416–24. https://doi.org/10.1002/mus.26798.
Benacchio, Simon, Olivier Doutres, Arthur Varoquaux, Éric Wagnac, Arnaud Le Troter, Virginie Callot, and Franck Sgard. “Use of Magnetic Resonance Image Registration to Estimate Displacement in the Human Earcanal Due to the Insertion of In-Ear Devices.” The Journal of the Acoustical Society of America 146, no. 4 (October 2019): 2452. https://doi.org/10.1121/1.5126857.
Kammoun, Malek, Jerome Piquereau, Lydie Nadal-Desbarats, Sandra Même, Maud Beuvin, Gisèle Bonne, Vladimir Veksler, et al. “Novel Role of Tieg1 in Muscle Metabolism and Mitochondrial Oxidative Capacities.” Acta Physiologica (Oxford, England), September 27, 2019, e13394. https://doi.org/10.1111/apha.13394.
Radulesco, Thomas, Ugo Scemama, Julien Mancini, Guy Moulin, Patrick Dessi, Justin Michel, and Arthur Varoquaux. “Role of Diffusion-Weighted Imaging in the Discrimination of Purulent Intrasinusal Content: A Retrospective Study.” Clinical Otolaryngology: Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery 44, no. 5 (September 2019): 762–69. https://doi.org/10.1111/coa.13388.
Felici, F., U. Scemama, D. Bendahan, J.-P. Lavieille, G. Moulin, C. Chagnaud, M. Montava, and A. Varoquaux. “Improved Assessment of Middle Ear Recurrent Cholesteatomas Using a Fusion of Conventional CT and Non-EPI-DWI MRI.” AJNR. American Journal of Neuroradiology 40, no. 9 (September 2019): 1546–51. https://doi.org/10.3174/ajnr.A6141.