Publications
180164
1
harvard-cite-them-right-no-et-al
50
date
desc
year
718
https://crmbm.univ-amu.fr/wp-content/plugins/zotpress/
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Jouenne, A., Sourdon, J., Varlet, I., Vilmen, C., Kober, F., Landrier, J.F., Bernard, M. and Desrois, M. (2025) ‘Resveratrol protection against cardiac remodeling and ischemia-reperfusion injury associated with hepatic lipid metabolism ameliorations and adipose tissue autotaxin pathway inhibition in a diet induced prediabetic female rat model’, The Journal of Nutritional Biochemistry, p. 109992. Available at: https://doi.org/10.1016/j.jnutbio.2025.109992.
Verdu-Diaz, J., Bolano-Díaz, C., Gonzalez-Chamorro, A., Fitzsimmons, S., Warman-Chardon, J., Kocak, G.S., Mucida-Alvim, D., Smith, I.C., Vissing, J., Poulsen, N.S., Luo, S., Domínguez-González, C., Bermejo-Guerrero, L., Gomez-Andres, D., Sotoca, J., Pichiecchio, A., Nicolosi, S., Monforte, M., Brogna, C., Mercuri, E., Bevilacqua, J.A., Díaz-Jara, J., Pizarro-Galleguillos, B., Krkoska, P., Alonso-Pérez, J., Olivé, M., Niks, E.H., Kan, H.E., Lilleker, J., Roberts, M., Buchignani, B., Shin, J., Esselin, F., Le Bars, E., Childs, A.M., Malfatti, E., Sarkozy, A., Perry, L., Sudhakar, S., Zanoteli, E., Di Pace, F.T., Matthews, E., Attarian, S., Bendahan, D., Garibaldi, M., Fionda, L., Alonso-Jiménez, A., Carlier, R., Okhovat, A.A., Nafissi, S., Nalini, A., Vengalil, S., Hollingsworth, K., Marini-Bettolo, C., Straub, V., Tasca, G., Bacardit, J., Díaz-Manera, J. and Myo‐Guide Consortium (2025) ‘Myo-Guide: A Machine Learning-Based Web Application for Neuromuscular Disease Diagnosis With MRI’, Journal of Cachexia, Sarcopenia and Muscle, 16(3), p. e13815. Available at: https://doi.org/10.1002/jcsm.13815.
Uher, D., Drenthen, G.S., Hoeberigs, C.M., van Lanen, R.H.G.J., Colon, A.J., Haast, R.A.M., van Kranen-Mastenbroek, V.H.J.M., Widman, G., Hofman, P.A.M., Wagner, L.G., Beckervordersandforth, J.C., Jansen, J.F.A., Schijns, O.E.M.G., Backes, W.H. and ACE study group (2025) ‘The role of ultra-high field MRI and image processing in the presurgical workup in MRI-negative focal epilepsy: A validated 7T MRI case study’, Epilepsy & Behavior Reports, 30, p. 100761. Available at: https://doi.org/10.1016/j.ebr.2025.100761.
Joppin, V., Bendahan, D., Ahmadi, A.A.E., Masson, C. and Bege, T. (2025) ‘Biomechanics of the abdominal wall before and after ventral hernia repair using dynamic MRI’, Hernia: The Journal of Hernias and Abdominal Wall Surgery, 29(1), p. 185. Available at: https://doi.org/10.1007/s10029-025-03337-4.
Jacquier, A., Tacher, V., Vidal, V., Kobeiter, H., Luciani, A., Boyer, L., Société Française d’imagerie cardiovasculaire diagnostique et interventionnelle (SFICV), Fédération de radiologie interventionnelle (FRI), Société Francaise de radiologie (SFR) and Conseil National Professionnel de Radiologie (G4) (2025) ‘Response to “2024 Global Statement Defining Interventional Radiology: Have We Reached the Tipping Point?”’, Cardiovascular and Interventional Radiology [Preprint]. Available at: https://doi.org/10.1007/s00270-025-04049-z.
Alonso-Ortiz, E., Papp, D., Barry, R.L., Poëti, K., Seifert, A.C., Gilbert, K.M., Lopez-Rios, N., Paska, J., Eippert, F., Weiskopf, N., Beghini, L., Graedel, N.N., Trampel, R., Callaghan, M.F., Aigner, C.S., Freund, P., Seif, M., Destruel, A., Callot, V., Vannesjo, J. and Cohen-Adad, J. (2025) ‘Multi-center benchmarking of cervical spinal cord RF coils for 7 T MRI: A traveling spines study’, Magnetic Resonance in Medicine [Preprint]. Available at: https://doi.org/10.1002/mrm.30551.
Mourre, H., Makhalova, J., Soncin, L., Garnier, E., Dary, H., Le Troter, A., Haast, R.A.M., Testud, B., Arthuis, M., Villalon, S.M., Lagarde, S., Pizzo, F., Bénar, C., Ranjeva, J.-P., Guye, M. and Bartolomei, F. (2025) ‘Nuclei-Specific Amygdala Enlargement Is Linked to Psychiatric Comorbidities in Drug-Resistant Focal Epilepsy’, Annals of Clinical and Translational Neurology [Preprint]. Available at: https://doi.org/10.1002/acn3.70071.
Plaindoux, A., Fur, Y.L., Courivaud, C., Beets, C., Samalens, L., Valette, J., Lemasson, B., Barbier, E.L., Stupar, V. and Fauvelle, F. (2025) ‘Mapping GABA+/Glx in experimental temporal lobe epilepsy using edited-MRSI at 9.4T’, NeuroImage, p. 121274. Available at: https://doi.org/10.1016/j.neuroimage.2025.121274.
Marignier, R., Villacieros-Álvarez, J., Espejo, C., Arrambide, G., Fissolo, N., Gutiérrez, L., Dinoto, A., Mulero, P., Rubio-Flores, L., Nieto, P., Alcalá, C., Meca-Lallana, J.E., Martínez-Garcia, P., Millán, J., Bernard-Valnet, R., González, I., Orvíz García, A., Tellez, R., Navarro, L., Presas-Rodríguez, S., Romero-Pinel, L., Martínez-Yélamos, S., Cuello, J.P., Alonso Torres, A.M., Piñar, R., Álvarez Bravo, G., Benyahya, L., Trouillet-Assant, S., Dyon-Tafani, V., Froment Tilikete, C., Ruet, A., Bourre, B., Deschamps, R., Papeix, C., Maillart, E., Kerschen, P., Ayrignac, X., Rovira, A., Auger, C., Audoin, B., Montalban, X., Tintore, M., Mariotto, S. and Cobo-Calvo, A. (2025) ‘Assessment of neuronal and glial serum biomarkers in myelin oligodendrocyte glycoprotein antibody-associated disease: the MULTIMOGAD study’, Journal of Neurology, Neurosurgery, and Psychiatry, p. jnnp-2024-335137. Available at: https://doi.org/10.1136/jnnp-2024-335137.
Cohen, M., Rollot, F., Debouverie, M., Zephir, H., Vukusic, S., De Seze, J., Labauge, P., Landes-Chateau, C., Mondot, L., Levraut, M., Ruet, A., Berger, E., Laplaud, D., Ciron, J., Bourre, B., Le Page, E., Papeix, C., Thouvenot, E., Al Khedr, A., Stankoff, B., Pelletier, J., Maillart, E., Casez, O., Moreau, T., Defer, G., Clavelou, P., Cabre, P., Moulin, S., Neau, J.P., Zedet, M., Hankiewicz, K., Doghri, I., Nasr, H.B., Pottier, C., Magy, L., Boulos, D.D., Heinzlef, O., Camdessanche, J.P., Coustans, M., Nifle, C., Brassat, D., Casey, R., Lebrun-Frenay, C. and OFSEP and SFSEP study groups (2025) ‘Secondary progression activity monitoring in MS despite an early highly active treatment the SPAM study’, European Journal of Neurology, 32(5), p. e16583. Available at: https://doi.org/10.1111/ene.16583.
Cotinat, M., Messaoudi, N., Robinet, E., Suissa, L., Doche, E., Guye, M., Audoin, B., Bensoussan, L., Ranjeva, J.-P. and Zaaraoui, W. (2025) ‘Dynamics of Ionic and Cytotoxic Edema During Acute and Subacute Stages of Patients With Ischemic Stroke: Complementarity of 23Na MRI and Diffusion MRI’, NMR in biomedicine, 38(5), p. e70028. Available at: https://doi.org/10.1002/nbm.70028.
Demortiere, S., Stolowy, N., Perriguey, M., Boutiere, C., Rico, A., Hilezian, F., Ndjomo-Ndjomo, B.-R., Durozard, P., Stellmann, J.-P., Marignier, R., Boucraut, J., Pelletier, J., Maarouf, A. and Audoin, B. (2025) ‘Diagnostic Utility of Kappa Free Light Chain Index in Adults With Inaugural Optic Neuritis’, Neurology(R) Neuroimmunology & Neuroinflammation, 12(3), p. e200386. Available at: https://doi.org/10.1212/NXI.0000000000200386.
Pennec, V.L., Douane, F., Brun, J.L., Thouveny, F., Martinelli, T., Bravetti, M., Mastier, C., Le Bras, Y., Rogopoulos, A., Barral, P.A., Marret, H., Chabrot, P., Jacquier, A., Senechal, Q., Doppelt, G. and Frandon, J. (2025) ‘Endovascular management of pelvic congestion syndrome: An expert consensus statement from the French Society of Cardiovascular Imaging (SFICV), Interventional Radiology Federation (FRI), College of French Radiology Teachers (CERF), and French Society of Women’s Imaging (SIFEM)’, Diagnostic and Interventional Imaging, pp. S2211-5684(25)00075–0. Available at: https://doi.org/10.1016/j.diii.2025.04.004.
Dollomaja, B., Wang, H.E., Guye, M., Makhalova, J., Bartolomei, F. and Jirsa, V.K. (2025) ‘Virtual epilepsy patient cohort: Generation and evaluation’, PLoS computational biology, 21(4), p. e1012911. Available at: https://doi.org/10.1371/journal.pcbi.1012911.
Cotinat, M., Robinet, E., Messaoudi, N., Suissa, L., Doche, E., Guye, M., Bensoussan, L., Zaaraoui, W. and Ranjeva, J.-P. (2025) ‘Added Value of Sodium MR Imaging and Proton MR Spectroscopy to Conventional MR Imaging for a Better Characterization of the Ischemic Stroke: A Narrative Review’, Magnetic resonance in medical sciences: MRMS: an official journal of Japan Society of Magnetic Resonance in Medicine [Preprint]. Available at: https://doi.org/10.2463/mrms.rev.2025-0002.
Hong, J., Gaubert, M., Lefort, M., Ferré, J.C., Le Page, E., Michel, L., Labauge, P., Pelletier, J., de Seze, J., Durand-Dubief, F., Cotton, F., Edan, G., Bannier, E., Combès, B. and Kerbrat, A. (2025) ‘Limited added value of systematic spinal cord MRI vs brain MRI alone to classify patients with MS as active or inactive during follow-up’, Journal of Neurology, 272(4), p. 316. Available at: https://doi.org/10.1007/s00415-025-13068-2.
Lodé, B., Hussein, B.R., Meurée, C., Walsh, R., Gaubert, M., Lassalle, N., Courbon, G., Martin, A., Le Bars, J., Durand-Dubief, F., Bourre, B., Maarouf, A., Outteryck, O., Mehier, C., Poulin, A., Cathelineau, C., Hong, J., Criton, G., Motillon-Alonso, S., Lecler, A., Charbonneau, F., Duron, L., Bani-Sadr, A., Delpierre, C., Ferré, J.-C., Edan, G., Cotton, F., Casey, R., Galassi, F., Combès, B. and Kerbrat, A. (2025) ‘Evaluation of a deep learning segmentation tool to help detect spinal cord lesions from combined T2 and STIR acquisitions in people with multiple sclerosis’, European Radiology [Preprint]. Available at: https://doi.org/10.1007/s00330-025-11541-0.
Piazzola, C., Graillon, T., Girard, N., Dufour, H., Brue, T. and Castinetti, F. (2025) ‘Desmopressin is a safe and effective secretagogue to replace corticotropin-releasing hormone in petrosal sinus sampling’, Annales d’Endocrinologie, 86(2), p. 101678. Available at: https://doi.org/10.1016/j.ando.2024.101678.
Bartolomei, F., Makhalova, J., Benoit, J. and Lagarde, S. (2025) ‘The different subtypes of temporal lobe seizures networks’, Revue Neurologique, pp. S0035-3787(25)00485–0. Available at: https://doi.org/10.1016/j.neurol.2025.03.004.
Barrit, S., Torcida, N., Mazeraud, A., Boulogne, S., Benoit, J., Carette, T., Carron, T., Delsaut, B., Diab, E., Kermorvant, H., Maarouf, A., Maldonado Slootjes, S., Redon, S., Robin, A., Hadidane, S., Harlay, V., Tota, V., Madec, T., Niset, A., Al Barajraji, M., Madsen, J.R., El Hadwe, S., Massager, N., Lagarde, S. and Carron, R. (2025) ‘Specialized Large Language Model Outperforms Neurologists at Complex Diagnosis in Blinded Case-Based Evaluation’, Brain Sciences, 15(4), p. 347. Available at: https://doi.org/10.3390/brainsci15040347.
Iftissen-Husser, F., Lavieille, J.-P. and Varoquaux, A. (2025) ‘Ultra-high resolution CT: A revolution in the evaluation of the temporal bone, middle and inner ear’, Diagnostic and Interventional Imaging, pp. S2211-5684(25)00047–6. Available at: https://doi.org/10.1016/j.diii.2025.03.003.
Roger, C., Lasbleiz, A., Dary, H., Pini, L., Ancel, P., Kovarova, A., Ranjeva, M.-P., Darmon, P., Gaborit, B., Fu, Y., Cozzone, P.J., Guye, M., Dutour, A. and Ranjeva, J.-P. (2025) ‘Structural alterations of individual hypothalamic nuclei in young females with obesity and anorexia nervosa: an in vivo 7-T MRI study’, The American Journal of Clinical Nutrition, pp. S0002-9165(25)00071–1. Available at: https://doi.org/10.1016/j.ajcnut.2025.02.003.
Testud, B., Destruel, A., Troalen, T., Ranjeva, J.-P. and Guye, M. (2025) ‘Review of 7T MRI imaging of pituitary microadenomas: are we there yet?’, Neuroradiology [Preprint]. Available at: https://doi.org/10.1007/s00234-025-03554-9.
Schilling, K.G., Grussu, F., Ianus, A., Hansen, B., Howard, A.F.D., Barrett, R.L.C., Aggarwal, M., Michielse, S., Nasrallah, F., Syeda, W., Wang, N., Veraart, J., Roebroeck, A., Bagdasarian, A.F., Eichner, C., Sepehrband, F., Zimmermann, J., Soustelle, L., Bowman, C., Tendler, B.C., Hertanu, A., Jeurissen, B., Verhoye, M., Frydman, L., van de Looij, Y., Hike, D., Dunn, J.F., Miller, K., Landman, B.A., Shemesh, N., Anderson, A., McKinnon, E., Farquharson, S., Dell’Acqua, F., Pierpaoli, C., Drobnjak, I., Leemans, A., Harkins, K.D., Descoteaux, M., Xu, D., Huang, H., Santin, M.D., Grant, S.C., Obenaus, A., Kim, G.S., Wu, D., Le Bihan, D., Blackband, S.J., Ciobanu, L., Fieremans, E., Bai, R., Leergaard, T.B., Zhang, J., Dyrby, T.B., Johnson, G.A., Cohen-Adad, J., Budde, M.D. and Jelescu, I.O. (2025) ‘Considerations and recommendations from the ISMRM diffusion study group for preclinical diffusion MRI: Part 2-Ex vivo imaging: Added value and acquisition’, Magnetic Resonance in Medicine [Preprint]. Available at: https://doi.org/10.1002/mrm.30435.
Villacieros-Álvarez, J., Espejo, C., Arrambide, G., Dinoto, A., Mulero, P., Rubio-Flores, L., Nieto, P., Alcalá, C., Meca-Lallana, J.E., Millan-Pascual, J., Martínez-García, P., Bernard-Valnet, R., González-Suárez, I., Orviz, A., Téllez, R., Navarro Cantó, L., Presas-Rodríguez, S., Martínez-Yélamos, S., Cuello, J.P., Alonso, A., Piñar Morales, R., Álvarez Bravo, G., Benyahya, L., Trouillet-Assant, S., Dyon-Tafan, V., Froment Tilikete, C., Ruet, A., Bourre, B., Deschamps, R., Papeix, C., Maillart, E., Kerschen, P., Ayrignac, X., Rovira, À., Auger, C., Audoin, B., Montalban, X., Tintore, M., Mariotto, S., Cobo-Calvo, A. and Marignier, R. (2025) ‘Profile and Usefulness of Serum Cytokines to Predict Prognosis in Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease’, Neurology(R) Neuroimmunology & Neuroinflammation, 12(2), p. e200362. Available at: https://doi.org/10.1212/NXI.0000000000200362.
Caradu, C., Webster, C., Nasr, B., Sobocinski, J., Louis, N., Thévenin, B., Goyault, G., Goueffic, Y., Ducasse, E. and LUMIFOLLOW collaborators (2025) ‘French multicentric registry on LUMINOR drug-eluting balloon for superficial femoral and popliteal arteries’, Journal of Vascular Surgery, 81(3), pp. 693-703.e3. Available at: https://doi.org/10.1016/j.jvs.2024.10.068.
Mainguy, M., Casey, R., Vukusic, S., Lebrun-Frenay, C., Berger, E., Kerbrat, A., Al Khedr, A., Bourre, B., Ciron, J., Clavelou, P., De Seze, J., Defer, G., Doghri, I., Dos Santos, A., Hankiewicz, K., Labauge, P.M., Le Page, E., Magy, L., Maillart, E., Manchon, E., Michel, L., Moreau, T., Moulin, S., Pelletier, J., Pottier, C., Ruet, A., Sarov, M., Stankoff, B., Thouvenot, E., Wahab, A., Zephir, H., Leray, E. and Laplaud, D.A. (2025) ‘Assessing the Risk of Relapse After In Vitro Fertilization in Women With Multiple Sclerosis’, Neurology(R) Neuroimmunology & Neuroinflammation, 12(2), p. e200371. Available at: https://doi.org/10.1212/NXI.0000000000200371.
Bouachba, A., De Jesus Neves, J., Royer, E., Bartin, R., Salomon, L.J., Grevent, D. and Gorincour, G. (2025) ‘Artificial intelligence, radiomics and fetal ultrasound: review of literature and future perspectives’, Ultrasound in Obstetrics & Gynecology: The Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology, 65(3), pp. 281–291. Available at: https://doi.org/10.1002/uog.29172.
Guttieres, L., Vannelli, L., Demortiere, S., Perriguey, M., Elziere, M., Durozard, P., Boutiere, C., Rico, A., Hilezian, F., Stellmann, J.-P., Pelletier, J., Maarouf, A., Stolowy, N. and Audoin, B. (2025) ‘Fluorescein Angiography as a Surrogate Marker of Disease Activity in Susac Syndrome’, Neurology(R) Neuroimmunology & Neuroinflammation, 12(2), p. e200379. Available at: https://doi.org/10.1212/NXI.0000000000200379.
Barral, P.-A., Ghelfi, J., Bravetti, M., Willoteaux, S., Agostini, A., Janot, K., Legendre, G., Torre, A., Midulla, M., Thouveny, F., Poclet, T., Rousset, P., Vernhet-Kovacsik, H., Jacquier, A., Marret, H. and Miquel, L. (2025) ‘Appropriateness of treatments for postpartum and post-abortion uterine vascular anomalies’, European Journal of Obstetrics, Gynecology, and Reproductive Biology, 308, pp. 132–142. Available at: https://doi.org/10.1016/j.ejogrb.2025.02.041.
Schilling, K.G., Howard, A.F.D., Grussu, F., Ianus, A., Hansen, B., Barrett, R.L.C., Aggarwal, M., Michielse, S., Nasrallah, F., Syeda, W., Wang, N., Veraart, J., Roebroeck, A., Bagdasarian, A.F., Eichner, C., Sepehrband, F., Zimmermann, J., Soustelle, L., Bowman, C., Tendler, B.C., Hertanu, A., Jeurissen, B., Verhoye, M., Frydman, L., van de Looij, Y., Hike, D., Dunn, J.F., Miller, K., Landman, B.A., Shemesh, N., Anderson, A., McKinnon, E., Farquharson, S., Dell’Acqua, F., Pierpaoli, C., Drobnjak, I., Leemans, A., Harkins, K.D., Descoteaux, M., Xu, D., Huang, H., Santin, M.D., Grant, S.C., Obenaus, A., Kim, G.S., Wu, D., Le Bihan, D., Blackband, S.J., Ciobanu, L., Fieremans, E., Bai, R., Leergaard, T.B., Zhang, J., Dyrby, T.B., Johnson, G.A., Cohen-Adad, J., Budde, M.D. and Jelescu, I.O. (2025) ‘Considerations and recommendations from the ISMRM Diffusion Study Group for preclinical diffusion MRI: Part 3-Ex vivo imaging: Data processing, comparisons with microscopy, and tractography’, Magnetic Resonance in Medicine [Preprint]. Available at: https://doi.org/10.1002/mrm.30424.
Jelescu, I.O., Grussu, F., Ianus, A., Hansen, B., Barrett, R.L.C., Aggarwal, M., Michielse, S., Nasrallah, F., Syeda, W., Wang, N., Veraart, J., Roebroeck, A., Bagdasarian, A.F., Eichner, C., Sepehrband, F., Zimmermann, J., Soustelle, L., Bowman, C., Tendler, B.C., Hertanu, A., Jeurissen, B., Verhoye, M., Frydman, L., van de Looij, Y., Hike, D., Dunn, J.F., Miller, K., Landman, B.A., Shemesh, N., Anderson, A., McKinnon, E., Farquharson, S., Dell’Acqua, F., Pierpaoli, C., Drobnjak, I., Leemans, A., Harkins, K.D., Descoteaux, M., Xu, D., Huang, H., Santin, M.D., Grant, S.C., Obenaus, A., Kim, G.S., Wu, D., Le Bihan, D., Blackband, S.J., Ciobanu, L., Fieremans, E., Bai, R., Leergaard, T.B., Zhang, J., Dyrby, T.B., Johnson, G.A., Cohen-Adad, J., Budde, M.D. and Schilling, K.G. (2025) ‘Considerations and recommendations from the ISMRM diffusion study group for preclinical diffusion MRI: Part 1: In vivo small-animal imaging’, Magnetic Resonance in Medicine [Preprint]. Available at: https://doi.org/10.1002/mrm.30429.
Senlis, J., Labombarda, F., Burel, J., Flouriot, A., Normant, S., Demeyere, M., Lairez, O., Ghannudi, S.E., Jacquier, A., Ghekiere, O., Cadour, F. and Dacher, J.-N. (2025) ‘Cardiac magnetic resonance imaging in the follow-up of patients with Fabry cardiomyopathy’, Diagnostic and Interventional Imaging, pp. S2211-5684(25)00008–7. Available at: https://doi.org/10.1016/j.diii.2025.02.002.
de Sèze, J., Labauge, P., Liblau, R., Martinez, M., Moreau, T., Suchet, L., Vermersch, P., Vukusic, S., Mathey, G., Michel, L., Ciron, J., Ruet, A., Maillart, E., Zephir, H., Papeix, C., Defer, G., Cohen, M., Laplaud, D.A., Berger, E., Clavelou, P., Thouvenot, E., Heinzlef, O., Pelletier, J., Giannesini, C., Casez, O., Bourre, B., Wahab, A., Magy, L., Camdessanché, J.-P., Doghri, I., Labeyrie, C., Hankiewicz, K., Neau, J.-P., Pottier, C., Dobay, P., Li, H., Levin, S., Gros, M., Ruiz, M. and Rollot, F. (2025) ‘LymphoTEC: a Retrospective Real-World Study on Lymphocyte Reconstitution After Lymphopenia in Patients with Multiple Sclerosis Treated with Dimethyl Fumarate in France’, Advances in Therapy [Preprint]. Available at: https://doi.org/10.1007/s12325-024-03092-5.
Erol, M.E., Bannon, S.T., Matias, A.A., Siokas, T., Nagarajan, R., Fur, Y.L., Park, S.-Y. and Layec, G. (2025) ‘Mitochondrial efficiency in resting skeletal muscle in vivo: a novel non-invasive approach using multinuclear magnetic resonance spectroscopy in humans’, The Journal of Physiology [Preprint]. Available at: https://doi.org/10.1113/JP287412.
Stolowy, N., Gutmann, L., Lüpke, M., David, T., Dorr, M., Mayer, C., Heesen, C., Oertel, F.C., Lin, T.-Y., Paul, F., Zimmermann, H.G. and Stellmann, J.-P. (2025) ‘OCT-Based Retina Assessment Reflects Visual Impairment in Multiple Sclerosis’, Investigative Ophthalmology & Visual Science, 66(2), p. 39. Available at: https://doi.org/10.1167/iovs.66.2.39.
Rossillon, A., Massad, N., Sagnet, R., Soler, R., Gaudry, M., Magnan, P.-E. and Bartoli, M.-A. (2025) ‘Long-Term Outcomes of Fenestrated Aortic Endovascular Repair in Patients Bearing JuxtaRenal Aneurysms’, Annals of Vascular Surgery, 111, pp. 250–259. Available at: https://doi.org/10.1016/j.avsg.2024.11.001.
Bartoli, A., Gnasso, C., Palmisano, A., Bettinelli, A., Vignale, D. and Esposito, A. (2025) ‘Myocardial Characterization on CT: Late Iodine Enhancement and Extracellular Volume’, Echocardiography (Mount Kisco, N.Y.), 42(2), p. e70108. Available at: https://doi.org/10.1111/echo.70108.
Baudouard, M., Guivier-Curien, C., Rapacchi, S., Jacquier, A. and Deplano, V. (2025) ‘Aortic displacement reconstruction to build a patient-specific computational model’, Multidisciplinary Biomechanics Journal, 49th congress of the Société de Biomécanique(Cardiovascular and respiratory biomechanics). Available at: https://doi.org/10.46298/mbj.14485.
Cho, S., Makhalova, J., Medina Villalon, S., Villeneuve, N., Trébuchon, A., Krouma, M., Scavarda, D., Lépine, A., Milh, M., Carron, R., Bonini, F., Daquin, G., Aubert, S., Lagarde, S., Pizzo, F. and Bartolomei, F. (2025) ‘Stereoelectroencephalographic exploration and surgical outcome in Lennox-Gastaut syndrome’, Epilepsia [Preprint]. Available at: https://doi.org/10.1111/epi.18283.
Pham, S.D.T., Chatziantoniou, C., van Vliet, J.T., van Tuijl, R.J., Bulk, M., Costagli, M., de Rochefort, L., Kraff, O., Ladd, M.E., Pine, K., Ronen, I., Siero, J.C.W., Tosetti, M., Villringer, A., Biessels, G.J. and Zwanenburg, J.J.M. (2025) ‘Blood Flow Velocity Analysis in Cerebral Perforating Arteries on 7T 2D Phase Contrast MRI with an Open-Source Software Tool (SELMA)’, Neuroinformatics, 23(2), p. 11. Available at: https://doi.org/10.1007/s12021-024-09703-4.
Licht, C., Ilicak, E., Boada, F.E., Guye, M., Zöllner, F.G., Schad, L.R. and Rapacchi, S. (2025) ‘A noise-robust post-processing pipeline for accelerated phase-cycled 23Na Multi-Quantum Coherences MRI’, Zeitschrift Fur Medizinische Physik, pp. S0939-3889(24)00117-X. Available at: https://doi.org/10.1016/j.zemedi.2024.12.004.
Ramdani, R., Pique, J., Deschamps, R., Ciron, J., Maillart, E., Audoin, B., Cohen, M., Zephir, H., Laplaud, D., Ayrignac, X., Collongues, N., Ruet, A., Thouvenot, E., Bourre, B., Papeix, C., Benyahya, L., Marignier, R. and NOMADMUS Study Group (2025) ‘Evaluation of the predictive value of CSF-restricted oligoclonal bands on residual disability and risk of relapse in adult patients with MOGAD: MOGADOC study’, Multiple Sclerosis (Houndmills, Basingstoke, England), p. 13524585241311436. Available at: https://doi.org/10.1177/13524585241311435.
Martin, S., André, R., Trabelsi, A., Michel, C.P., Fortanier, E., Attarian, S., Guye, M., Dubois, M., Abdeddaim, R. and Bendahan, D. (2025) ‘Importance of neural network complexity for the automatic segmentation of individual thigh muscles in MRI images from patients with neuromuscular diseases’, Magma (New York, N.Y.) [Preprint]. Available at: https://doi.org/10.1007/s10334-024-01221-3.
Farah, K., Mchinda, S., Pini, L., Baucher, G., Roche, P.-H., Fuentes, S. and Callot, V. (2025) ‘T1 mapping using MP2RAGE in degenerative cervical myelopathy: a longitudinal study’, European Spine Journal [Preprint]. Available at: https://doi.org/10.1007/s00586-025-08652-z.
Bertho, W., Van Weydevelt, E., Rossillon, A., Bartoli, M.-A., Mesnard, T., Sobocinski, J., Hostalrich, A., Chaufour, X., Lalys, F. and Kaladji, A. (2025) ‘Prediction of Late Proximal Endoleak Risk after EVAR by Preoperative Estimation of Endograft/Aortic Neck Apposition Surface’, Annals of Vascular Surgery, 110(Pt B), pp. 440–449. Available at: https://doi.org/10.1016/j.avsg.2024.09.050.
Pérot, J.-B., Ruze, A., Gaurav, R., Rebbah, S., Cadin, C., Le Troter, A., Soustelle, L., Mouton, L., Valabrègue, R., Parent, A., Mangone, G., Lejeune, F.-X., Arnulf, I., Corvol, J.-C., Vidailhet, M., Santin, M.D., Vila, M. and Lehéricy, S. (2025) ‘Longitudinal neuromelanin changes in prodromal and early Parkinson’s disease in humans and rat model’, Brain Communications, 7(3), p. fcaf204. Available at: https://doi.org/10.1093/braincomms/fcaf204.
Kretschmer, J.R., Tkachenko, D., Kümpfel, T., Havla, J., Engels, D., Paul, F., Schindler, P., Bellmann-Strobl, J., Berthele, A., Giglhuber, K., Zappe, C., Klotz, L., Revie, L., Dawin, E., Senel, M., Tumani, H., Bergh, F.T., Warnke, C., Kraemer, M., Walter, A., Bayas, A., Zettl, U.K., Lauenstein, A.-S., Yalachkov, Y., Etgen, T., Kaste, M., Luessi, F., Gingele, S., Passoke, S., Weber, M.S., Sieb, J.P., Haarmann, A., Oschmann, P., Rothhammer, V., Geis, C., Kowarik, M.C., Kern, P., Grothe, M., Stephanik, H., Angstwurm, K., Hoffmann, F., Wallwitz, U., Wildemann, B., Jarius, S., Stellmann, J.-P., Pakeerathan, T., Schwake, C., Ayzenberg, I., Kleiter, I., Fischer, K., Aktas, O., Ringelstein, M., Häußler, V., Trebst, C. and Hümmert, M.W. (2025) ‘Worse recovery from acute attacks and faster disability accumulation highlights the unmet need for improved treatment in patients with late-onset neuromyelitis optica spectrum disorders (COPTER-LO study)’, Frontiers in Immunology, 16, p. 1575613. Available at: https://doi.org/10.3389/fimmu.2025.1575613.
Fortanier, E., Michel, C.P., Hostin, M.A., Delmont, E., Verschueren, A., Guye, M., Bellemare, M.-E., Bendahan, D. and Attarian, S. (2025) ‘Quantitative muscle MRI combined with AI-based segmentation as a follow-up biomarker for ATTRv patients: A longitudinal pilot study’, European Journal of Neurology, 32(1), p. e16574. Available at: https://doi.org/10.1111/ene.16574.
Biagioni, T., Fratello, M., Garnier, E., Lagarde, S., Carron, R., Medina Villalon, S., Lambert, I., Marchi, A., Makhalova, J., Trebuchon, A., Bonini, F., Scavarda, D., Benar, C., Bartolomei, F. and Pizzo, F. (2025) ‘Interictal waking and sleep electrophysiological properties of the thalamus in focal epilepsies’, Brain Communications, 7(2), p. fcaf102. Available at: https://doi.org/10.1093/braincomms/fcaf102.