Nutrition, Lipids and Health Programming (DOHaD concept)

Research Works

This work is part of the research domain on the “first 1000 days” of life (from conception to 2 years of age) in connection with DOHaD concept (Developmental Origins of Health and Diseases) according to which chronic diseases, that are increasing exponentially in our century, originate very early in life due to an unfavorable environment (exposome). This early period of life has been recognized since 2012 by the WHO as being decisive in the development of the child and of the health of the future becoming adult. Indeed, the exposome that an individual is confronted with in this “critical window” is at the origin of the programming of chronic diseases that will manifest themselves later in life (in adolescence, in adulthood) or even from early childhood. This period is a source of inequities in the protection against the risk for cardiovascular, neurological, and metabolic (obesity, diabetes) diseases, and has been identified as a target to focus on to stop the expansion of such chronic diseases. Nutrition, and specifically exposure to omega 3 and omega 6 polyunsaturated fatty acids (PUFA) (using GC technology), or to phospholipids (using P31-NMR methodology), are the main factors studied.

Lab’s members involved:
Martine Armand (Senior Research Scientist, INSERM)
Catherine Sarté (ASSI-CDD, AMU)
Patrick Viout (Clinical Technician, AP-HM)
Yann Le-Fur (Research Engineer, CNRS)

List of research projects:

•  Lipids and health programming in birth cohort-studies:
  – in the French birth cohorts EDEN and ELFE in collaboration with CRESS UMR 1153 INSERM, EARoH Team, Barbara Heude, Jonathan Bernard, Marie-Aline Charles, Villejuif (EDEN cohort;ELFE cohort);
  – in the preterm birth cohort EPIPAGE 2 (subgroup EPINUTRI) in collaboration with Alexandre Lapillonne, Necker Children Hospital, APHP, Paris;
• Milk bioactive molecules and health (PUFA, Phospholipids)
  – in collaboration with the neonatology department at Nord Hospital Marseille, Catherine Gire, Véronique Brévaut-Malaty, Barthélémy Tosselo.
  – in rodent longitudinal studies in collaboration with INSERM 1055 LBFA, Grenoble-Alpes University, Karine Couturier, Grenoble.