SC#4 – Pathological SC MR investigations

Research Works

New protocols including anatomical and parametric MRI (morphometry, DTI, MT/ihMT, T1 mapping) are investigated on both high and ultra-high field MR systems in order to better characterize human SC pathologies, in terms of diagnostic, prognostic and evaluation of the potential recovery.

Current investigations more particularly concern cervical myelopathy (CSM), as well as amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS).

Recent results demonstrated the added values of ihMTR (inhomogeneous magnetization transfer ratio) in demyelinating pathologies such as MS, strong atrophy (Cross Sectional Area measurements, CSA) in ALS, as well as great potential of MP2RAGE acquisitions in the detection of MS lesion.


          Multiparametric MR imaging in ALS patients at 3T (from Rasoanandrianina et al, 2017)
             Improved SC lesion detection in MS using 3T MP2RAGE (from Demortière et al., 2020)
3T vs. 7T MRI – Improved lesion detection using 7T


Close Collaborators – APHM

Pr. PH. Roche (Neurosurgery);
Pr. B. Audoin, Pr. J. Pelletier, Dr. S. Demortière (Neurology);
Dr. A. Verschueren, Pr. S. Attarian, Dr. AM. Grapperon (Neurology and Neuromuscular Diseases);
Dr. JB. Grisoli (Sports Medicine)



Acknowledgments : we deeply thank our patients and their family for their participation. We strongly acknowledge grant supports from Fondation ARSEP (aide à la recherche sur la sclérose en plaques) and Fondation de France / Fondation thierry Latran.



Associated Keywords

  • Multiple Sclerosis
  • New MR Biomarkers
  • Spinal Cord
  • Ultra-high field MRI