FREBOURG Guillaume

PhD Student / AMU

spinal cord MRI

PhD Student

Download my Resume (EN)

Detailed Activities

The general objective of the Spinal Cord MR Imaging research group is to improve the non invasive characterization of the spinal cord impairments and to help in the description of the spinal cord pathophysiological mechanisms using quantitative and multi-parametric Magnetic Resonance Imaging.

My objective during my thesis, co-directed between Marseille and Montreal, is to carry out a structural analysis of the spinal cord in cervical spondylotic myelopathy and central cord syndrome using Diffusion and Perfusion weighted images at 7T to find new biomarkers. Then, to study the stresses and strains during biomechanical simulation in order to identify biomarkers related to those found in MRI.

This project aims to combine MR and biomechanical computational modeling in order to provide an extensive and multi-physic description of traumatic and degenerative spinal cord pathologies (International Research Laboratory (IRL/LIA) “iLab-Spine ”, France/Canada).


  • Image Processing
  • New MR Biomarkers
  • Perfusion Methods
  • Quantitative MRI
  • Spinal Cord
  • Ultra-high field MRI

Research Projects


Oral Presentation:
G. Frebourg, A. Massire, L. Pini, M.Guye, B. Audoin, A. Veschueren, P.-H. Roche, V. Callot. The good, the bad and the ugly : a retrospective study of human cervical spinal cord image quality at 7T. ISMRM annual meetings (2021).
G. Frebourg , P. Sudres, V. Callot, M. Evin. MR-based Quasi-Automatic Segmentation and 3D reconstruction of the Cervical Subarachnoid Space. Nominated for the Best Poster Award. 45th Congress of the Société de Biomécanique (2020).

Publications :

Sellal, F., Wallon, D., Martinez-Almoyna, L., Marelli, C., Dhar, A., Oesterlé, H., Rovelet-Lecrux, A., Rousseau, S., Kourkoulis, C.E., Rosand, J., DiPucchio, Z.Y., Frosch, M., Gombert, C., Audoin, B., Miné, M., Riant, F., Frebourg, T., Hannequin, D., Campion, D., Greenberg, S.M., Tournier-Lasserve, E. and Nicolas, G. (2017) ‘APP Mutations in Cerebral Amyloid Angiopathy with or without Cortical Calcifications: Report of Three Families and a Literature Review’, Journal of Alzheimer’s Disease, 56(1), pp. 37–46. Available at: