Cozzone Patrick

Professor Emeritus of Biophysics

Founder and Director Emeritus of CRMBM

Download my Resume (FR / EN)

Publications :

180164 Cozzone 1 harvard-cite-them-right-no-et-al 50 date desc year 3168 https://crmbm.univ-amu.fr/wp-content/plugins/zotpress/
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Roger, C., Lasbleiz, A., Dary, H., Pini, L., Ancel, P., Kovarova, A., Ranjeva, M.-P., Darmon, P., Gaborit, B., Fu, Y., Cozzone, P.J., Guye, M., Dutour, A. and Ranjeva, J.-P. (2025) “Structural alterations of individual hypothalamic nuclei in young females with obesity and anorexia nervosa: an in vivo 7-T MRI study,” The American Journal of Clinical Nutrition, pp. S0002-9165(25)00071–1. Available at: https://doi.org/10.1016/j.ajcnut.2025.02.003.
Norris, D.G., Haase, A. and Cozzone, P.J. (2023) “Celebrating 30 years of Magma’,” Magnetic Resonance Materials in Physics, Biology and Medicine, 36(1), pp. 1–2. Available at: https://doi.org/10.1007/s10334-023-01069-z.
Tromp, J., Seekings, P.J., Hung, C.-L., Iversen, M.B., Frost, M.J., Ouwerkerk, W., Jiang, Z., Eisenhaber, F., Goh, R.S.M., Zhao, H., Huang, W., Ling, L.-H., Sim, D., Cozzone, P., Richards, A.M., Lee, H.K., Solomon, S.D., Lam, C.S.P. and Ezekowitz, J.A. (2022) “Automated interpretation of systolic and diastolic function on the echocardiogram: a multicohort study,” The Lancet. Digital Health, 4(1), pp. e46–e54. Available at: https://doi.org/10.1016/S2589-7500(21)00235-1.
Escande-Beillard, N., Loh, A., Saleem, S.N., Kanata, K., Hashimoto, Y., Altunoglu, U., Metoska, A., Grandjean, J., Ng, F.M., Pomp, O., Baburajendran, N., Wong, J., Hill, J., Beillard, E., Cozzone, P., Zaki, M., Kayserili, H., Hamada, H., Shiratori, H. and Reversade, B. (2020) “Loss of PYCR2 Causes Neurodegeneration by Increasing Cerebral Glycine Levels via SHMT2,” Neuron, 107(1), pp. 82-94.e6. Available at: https://doi.org/10.1016/j.neuron.2020.03.028.
Charles, C.J., Lee, P., Li, R.R., Yeung, T., Ibraham Mazlan, S.M., Tay, Z.W., Abdurrachim, D., Teo, X.Q., Wang, W.-H., de Kleijn, D.P.V., Cozzone, P.J., Lam, C.S.P. and Richards, A.M. (2020) “A porcine model of heart failure with preserved ejection fraction: magnetic resonance imaging and metabolic energetics,” ESC heart failure, 7(1), pp. 92–102. Available at: https://doi.org/10.1002/ehf2.12536.
Lum, F.-M., Zhang, W., Lim, K.-C., Malleret, B., Teo, T.-H., Koh, J.-J., Lee, K.J., Chua, T.-K., Kam, Y.-W., Yee, W.-X., Huen, I., Tan, J.J.L., Amrun, S.N., Prakash Kn, B., Cozzone, P.J., Renia, L., Lee, P.T.H. and Ng, L.F.P. (2018) “Multimodal assessments of Zika virus immune pathophysiological responses in marmosets,” Scientific Reports, 8(1), p. 17125. Available at: https://doi.org/10.1038/s41598-018-35481-6.
Cozzone, P.J. (2017) “A note from Patrick J. Cozzone, MAGMA Editor-in-Chief,” Magnetic Resonance Materials in Physics, Biology and Medicine, 30(6), pp. 517–518. Available at: https://doi.org/10.1007/s10334-017-0662-8.
Layec, G., Bringard, A., LE Fur, Y., Micallef, J.-P., Vilmen, C., Perrey, S., Cozzone, P.J. and Bendahan, D. (2016) “Mitochondrial Coupling and Contractile Efficiency in Humans with High and Low V˙O2peaks,” Medicine and Science in Sports and Exercise, 48(5), pp. 811–821. Available at: https://doi.org/10.1249/MSS.0000000000000858.
Sdika, M., Tonson, A., Le Fur, Y., Cozzone, P.J. and Bendahan, D. (2016) “Multi-atlas-based fully automatic segmentation of individual muscles in rat leg,” Magma (New York, N.Y.), 29(2), pp. 223–235. Available at: https://doi.org/10.1007/s10334-015-0511-6.
Bernard, M., Maixent, J.-M., Gerbi, A., Lan, C., Cozzone, P.J., Pieroni, G., Armand, M. and Coste, T.C. (2016) “Dietary docosahexaenoic acid-enriched glycerophospholipids exert cardioprotective effects in ouabain-treated rats via physiological and metabolic changes,” Food & Function, 7(2), pp. 798–804. Available at: https://doi.org/10.1039/c5fo01300c.
Koob, M., Viola, A., Le Fur, Y., Viout, P., Ratiney, H., Confort-Gouny, S., Cozzone, P.J. and Girard, N. (2016) “Creatine, Glutamine plus Glutamate, and Macromolecules Are Decreased in the Central White Matter of Premature Neonates around Term,” PloS One, 11(8), p. e0160990. Available at: https://doi.org/10.1371/journal.pone.0160990.
Lutz, N.W., Banerjee, P., Wilson, B.J., Ma, J., Cozzone, P.J. and Frank, M.H. (2016) “Expression of Cell-Surface Marker ABCB5 Causes Characteristic Modifications of Glucose, Amino Acid and Phospholipid Metabolism in the G3361 Melanoma-Initiating Cell Line,” PloS One, 11(8), p. e0161803. Available at: https://doi.org/10.1371/journal.pone.0161803.
Prevost, V.H., Girard, O.M., Callot, V., Cozzone, P.J. and Duhamel, G. (2015) “Fast imaging strategies for mouse kidney perfusion measurement with pseudocontinuous arterial spin labeling (pCASL) at ultra high magnetic field (11.75 tesla),” Journal of Magnetic Resonance Imaging, 42(4), pp. 999–1008. Available at: https://doi.org/10.1002/jmri.24874.
Lecocq, A., Le Fur, Y., Maudsley, A.A., Le Troter, A., Sheriff, S., Sabati, M., Donadieu, M., Confort-Gouny, S., Cozzone, P.J., Guye, M. and Ranjeva, J.-P. (2015) “Whole-brain quantitative mapping of metabolites using short echo three-dimensional proton MRSI,” Journal of magnetic resonance imaging: JMRI, 42(2), pp. 280–289. Available at: https://doi.org/10.1002/jmri.24809.
Girard, O.M., Prevost, V.H., Varma, G., Cozzone, P.J., Alsop, D.C. and Duhamel, G. (2015) “Magnetization transfer from inhomogeneously broadened lines (ihMT): Experimental optimization of saturation parameters for human brain imaging at 1.5 Tesla,” Magnetic Resonance in Medicine, 73(6), pp. 2111–2121. Available at: https://doi.org/10.1002/mrm.25330.
Jubeau, M., LE Fur, Y., Duhamel, G., Wegrzyk, J., Confort-Gouny, S., Vilmen, C., Cozzone, P.J., Mattei, J.P., Bendahan, D. and Gondin, J. (2015) “Localized metabolic and t2 changes induced by voluntary and evoked contractions,” Medicine and Science in Sports and Exercise, 47(5), pp. 921–930. Available at: https://doi.org/10.1249/MSS.0000000000000491.
Layec, G., Bringard, A., Le Fur, Y., Micallef, J.-P., Vilmen, C., Perrey, S., Cozzone, P.J. and Bendahan, D. (2015) “Opposite effects of hyperoxia on mitochondrial and contractile efficiency in human quadriceps muscles,” American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 308(8), pp. R724-733. Available at: https://doi.org/10.1152/ajpregu.00461.2014.
Lecocq, A., Le Fur, Y., Amadon, A., Vignaud, A., Cozzone, P.J., Guye, M. and Ranjeva, J.-P. (2015) “Fast water concentration mapping to normalize (1)H MR spectroscopic imaging,” Magma (New York, N.Y.), 28(1), pp. 87–100. Available at: https://doi.org/10.1007/s10334-014-0451-6.
Le Fur, Y. and Cozzone, P.J. (2015) “Hemi-spectrum substitution after water signal fitting (HESWAF): an improvement of the modulus post-processing of MR spectra,” Magma (New York, N.Y.), 28(1), pp. 67–85. Available at: https://doi.org/10.1007/s10334-014-0444-5.
Desrois, M., Piccardo, A., Zogheib, E., Dalmasso, C., Lan, C., Fourré, D., Cozzone, P.J., Caus, T. and Bernard, M. (2014) “Heart donation after cardiac death: preliminary study on an isolated, perfused Swine heart after 20 minutes of normothermic ischemia,” Transplantation Proceedings, 46(10), pp. 3314–3318. Available at: https://doi.org/10.1016/j.transproceed.2014.04.021.
Lutz, N.W., Béraud, E. and Cozzone, P.J. (2014) “Metabolomic Analysis of Rat Brain by High Resolution Nuclear Magnetic Resonance Spectroscopy of Tissue Extracts,” Journal of Visualized Experiments, (91), p. e51829. Available at: https://doi.org/10.3791/51829.
Gondin, J., Vilmen, C., Cozzone, P.J., Bendahan, D. and Duhamel, G. (2014) “High-field (11.75T) multimodal MR imaging of exercising hindlimb mouse muscles using a non-invasive combined stimulation and force measurement device,” NMR in biomedicine, 27(8), pp. 870–879. Available at: https://doi.org/10.1002/nbm.3122.
Grapperon, A.-M., Verschueren, A., Duclos, Y., Confort-Gouny, S., Soulier, E., Loundou, A.D., Guye, M., Cozzone, P.J., Pouget, J., Ranjeva, J.-P. and Attarian, S. (2014) “Association between structural and functional corticospinal involvement in amyotrophic lateral sclerosis assessed by diffusion tensor MRI and triple stimulation technique,” Muscle & Nerve, 49(4), pp. 551–557. Available at: https://doi.org/10.1002/mus.23957.
Le Fur, Y. and Cozzone, P.J. (2014) “FID modulus: a simple and efficient technique to phase and align MR spectra,” Magnetic Resonance Materials in Physics, Biology and Medicine, 27(2), pp. 131–148. Available at: https://doi.org/10.1007/s10334-013-0381-8.
Duhamel, G., Prevost, V., Girard, O.M., Callot, V. and Cozzone, P.J. (2014) “High-resolution mouse kidney perfusion imaging by pseudo-continuous arterial spin labeling at 11.75T,” Magnetic Resonance in Medicine, 71(3), pp. 1186–1196. Available at: https://doi.org/10.1002/mrm.24740.
Maarouf, A., Audoin, B., Konstandin, S., Rico, A., Soulier, E., Reuter, F., Troter, A.L., Confort-Gouny, S., Cozzone, P.J., Guye, M., Schad, L.R., Pelletier, J., Ranjeva, J.-P. and Zaaraoui, W. (2014) “Topography of brain sodium accumulation in progressive multiple sclerosis,” Magnetic Resonance Materials in Physics, Biology and Medicine, 27(1), pp. 53–62. Available at: https://doi.org/10.1007/s10334-013-0396-1.
Ratel, S., Tonson, A., Cozzone, P.J. and Bendahan, D. (2014) “The rate of PCr resynthesis is not a reliable index of skeletal muscle oxidative capacity,” European Journal of Applied Physiology, 114(1), pp. 217–218. Available at: https://doi.org/10.1007/s00421-013-2765-x.
Gineste, C., Ottenheijm, C., Le Fur, Y., Banzet, S., Pecchi, E., Vilmen, C., Cozzone, P.J., Koulmann, N., Hardeman, E.C., Bendahan, D. and Gondin, J. (2014) “Alterations at the cross-bridge level are associated with a paradoxical gain of muscle function in vivo in a mouse model of nemaline myopathy,” PloS One, 9(9), p. e109066. Available at: https://doi.org/10.1371/journal.pone.0109066.
Desrois, M., Kober, F., Lan, C., Dalmasso, C., Cole, M., Clarke, K., Cozzone, P.J. and Bernard, M. (2014) “Effect of isoproterenol on myocardial perfusion, function, energy metabolism and nitric oxide pathway in the rat heart – a longitudinal MR study,” NMR in Biomedicine, 27(5), pp. 529–538. Available at: https://doi.org/10.1002/nbm.3088.
Layec, G., Malucelli, E., Le Fur, Y., Manners, D., Yashiro, K., Testa, C., Cozzone, P.J., Iotti, S. and Bendahan, D. (2013) “Effects of exercise-induced intracellular acidosis on the phosphocreatine recovery kinetics: a 31P MRS study in three muscle groups in humans,” NMR in Biomedicine, 26(11), pp. 1403–1411. Available at: https://doi.org/10.1002/nbm.2966.
Capron, T., Troalen, T., Cozzone, P.J., Bernard, M. and Kober, F. (2013) “Cine-ASL: a steady-pulsed arterial spin labeling method for myocardial perfusion mapping in mice. Part II. Theoretical model and sensitivity optimization,” Magnetic Resonance in Medicine, 70(5), pp. 1399–1408. Available at: https://doi.org/10.1002/mrm.24588.
Troalen, T., Capron, T., Cozzone, P.J., Bernard, M. and Kober, F. (2013) “Cine-ASL: a steady-pulsed arterial spin labeling method for myocardial perfusion mapping in mice. Part I. Experimental study,” Magnetic Resonance in Medicine, 70(5), pp. 1389–1398. Available at: https://doi.org/10.1002/mrm.24565.
Lutz, N.W., Fur, Y.L., Chiche, J., Pouysségur, J. and Cozzone, P.J. (2013) “Quantitative In Vivo Characterization of Intracellular and Extracellular pH Profiles in Heterogeneous Tumors: A Novel Method Enabling Multiparametric pH Analysis,” Cancer Research, 73(15), pp. 4616–4628. Available at: https://doi.org/10.1158/0008-5472.CAN-13-0767.
Fellah, S., Caudal, D., De Paula, A.M., Dory-Lautrec, P., Figarella-Branger, D., Chinot, O., Metellus, P., Cozzone, P.J., Confort-Gouny, S., Ghattas, B., Callot, V. and Girard, N. (2013) “Multimodal MR imaging (diffusion, perfusion, and spectroscopy): is it possible to distinguish oligodendroglial tumor grade and 1p/19q codeletion in the pretherapeutic diagnosis?,” AJNR. American journal of neuroradiology, 34(7), pp. 1326–1333. Available at: https://doi.org/10.3174/ajnr.A3352.
Tachrount, M., Duhamel, G., Laurin, J., Marqueste, T., de Paula, A.M., Decherchi, P., Cozzone, P.J. and Callot, V. (2013) “In vivo short TE localized (1) H MR spectroscopy of mouse cervical spinal cord at very high magnetic field (11.75 T),” Magnetic resonance in medicine, 69(5), pp. 1226–1232. Available at: https://doi.org/10.1002/mrm.24360.
Leporq, B., Le Troter, A., Le Fur, Y., Salort-Campana, E., Cozzone, P., Beuf, O. and Bendahan, D. (2013) “Combination of a Fat Volume Fraction Quantification Method with a Dedicated Automatic Segmentation Algorithm for Simultaneous Measurement of Infiltrated Fatty Tissue Fraction and Muscle Relaxation Times.,” in. ISMRM 21st Annual Meeting & Exhibition, Salt Lake City, Utah, USA.
Gineste, C., De Winter, J.M., Kohl, C., Witt, C.C., Giannesini, B., Brohm, K., Le Fur, Y., Gretz, N., Vilmen, C., Pecchi, E., Jubeau, M., Cozzone, P.J., Stienen, G.J.M., Granzier, H., Labeit, S., Ottenheijm, C.A.C., Bendahan, D. and Gondin, J. (2013) “In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype,” Neuromuscular disorders: NMD, 23(4), pp. 357–369. Available at: https://doi.org/10.1016/j.nmd.2012.12.011.
Moll, N., Reuter, F., Zaaraoui, W., Rico, A., Malikova, I., Crespy, L., Faivre, A., Loundou, A., Auquier, P., Cozzone, P., Ranjeva, J.P., Audoin, B. and Pelletier, J. (2013) “T2 Lesion Load Influences Cognitive Impairment at the Early Phase of MS,” Neurology, 80.
Lutz, N.W., Fernandez, C., Pellissier, J.-F., Cozzone, P.J. and Béraud, E. (2013) “Cerebral biochemical pathways in experimental autoimmune encephalomyelitis and adjuvant arthritis: a comparative metabolomic study,” PloS one, 8(2), p. e56101. Available at: https://doi.org/10.1371/journal.pone.0056101.
Gineste, C., Le Fur, Y., Vilmen, C., Le Troter, A., Pecchi, E., Cozzone, P.J., Hardeman, E.C., Bendahan, D. and Gondin, J. (2013) “Combined MRI and (31)P-MRS Investigations of the ACTA1(H40Y) Mouse Model of Nemaline Myopathy Show Impaired Muscle Function and Altered Energy Metabolism,” PloS one, 8(4), p. e61517. Available at: https://doi.org/10.1371/journal.pone.0061517.
Gineste, C., Duhamel, G., Le Fur, Y., Vilmen, C., Cozzone, P.J., Nowak, K.J., Bendahan, D. and Gondin, J. (2013) “Multimodal MRI and (31)P-MRS Investigations of the ACTA1(Asp286Gly) Mouse Model of Nemaline Myopathy Provide Evidence of Impaired In Vivo Muscle Function, Altered Muscle Structure and Disturbed Energy Metabolism,” PloS one, 8(8), p. e72294. Available at: https://doi.org/10.1371/journal.pone.0072294.
Garcia, C., Lutz, N.W., Confort-Gouny, S., Cozzone, P.J., Armand, M. and Bernard, M. (2012) “Phospholipid fingerprints of milk from different mammalians determined by 31P NMR: towards specific interest in human health,” Food Chemistry, 135(3), pp. 1777–1783. Available at: https://doi.org/10.1016/j.foodchem.2012.05.111.
Ratel, S., Martin, V., Tonson, A., Cozzone, P.J. and Bendahan, D. (2012) “Skeletal muscle mitochondrial function cannot be properly inferred from PCr resynthesis without taking pH changes into account,” Magnetic resonance imaging, 30(10), pp. 1542–1543. Available at: https://doi.org/10.1016/j.mri.2012.06.017.
Wybrecht, D., Reuter, F., Zaaraoui, W., Faivre, A., Crespy, L., Rico, A., Malikova, I., Confort-Gouny, S., Soulier, E., Cozzone, P.J., Pelletier, J., Ranjeva, J.-P. and Audoin, B. (2012) “Voxelwise analysis of conventional magnetic resonance imaging to predict future disability in early relapsing-remitting multiple sclerosis,” Multiple sclerosis (Houndmills, Basingstoke, England), 18(11), pp. 1585–1591. Available at: https://doi.org/10.1177/1352458512442991.
Bartoli, M.A., Kober, F., Cozzone, P., Thompson, R.W., Alessi, M.C. and Bernard, M. (2012) “In vivo assessment of murine elastase-induced abdominal aortic aneurysm with high resolution magnetic resonance imaging,” European journal of vascular and endovascular surgery: the official journal of the European Society for Vascular Surgery, 44(5), pp. 475–481. Available at: https://doi.org/10.1016/j.ejvs.2012.08.002.
Faivre, A., Rico, A., Zaaraoui, W., Crespy, L., Reuter, F., Wybrecht, D., Soulier, E., Malikova, I., Confort-Gouny, S., Cozzone, P.J., Pelletier, J., Ranjeva, J.-P. and Audoin, B. (2012) “Assessing brain connectivity at rest is clinically relevant in early multiple sclerosis,” Multiple sclerosis (Houndmills, Basingstoke, England), 18(9), pp. 1251–1258. Available at: https://doi.org/10.1177/1352458511435930.
Zaaraoui, W., Konstandin, S., Audoin, B., Nagel, A.M., Rico, A., Malikova, I., Soulier, E., Viout, P., Confort-Gouny, S., Cozzone, P.J., Pelletier, J., Schad, L.R. and Ranjeva, J.-P. (2012) “Distribution of brain sodium accumulation correlates with disability in multiple sclerosis: a cross-sectional 23Na MR imaging study,” Radiology, 264(3), pp. 859–867. Available at: https://doi.org/10.1148/radiol.12112680.
Layec, G., Bringard, A., Yashiro, K., Le Fur, Y., Vilmen, C., Micallef, J.-P., Perrey, S., Cozzone, P.J. and Bendahan, D. (2012) “The slow components of phosphocreatine and pulmonary oxygen uptake can be dissociated during heavy exercise according to training status,” Experimental physiology, 97(8), pp. 955–969. Available at: https://doi.org/10.1113/expphysiol.2011.062927.
Ratel, S., Martin, V., Tonson, A., Cozzone, P.J. and Bendahan, D. (2012) “Can we simply infer mitochondrial function from PCr resynthesis after exercise in skeletal muscle?,” Pediatric research, 72(2), p. 221. Available at: https://doi.org/10.1038/pr.2012.67.
Gaborit, B., Kober, F., Jacquier, A., Moro, P.J., Flavian, A., Quilici, J., Cuisset, T., Simeoni, U., Cozzone, P., Alessi, M.-C., Clément, K., Bernard, M. and Dutour, A. (2012) “Epicardial fat volume is associated with coronary microvascular response in healthy subjects: a pilot study,” Obesity (Silver Spring, Md.), 20(6), pp. 1200–1205. Available at: https://doi.org/10.1038/oby.2011.283.