BERNARD Monique

Research Director (PhD)

at CNRS

Director CRMBM
Co-head of the cardiovascular team

Research Director (PhD)

Download my Resume (FR )

Detailed Activities

My research interests are focused on the study of metabolic, physiological and functional alterations during cardiovascular pathologies related to diffuse or localized ischemia (atherosclerosis, diabetic and obesity related cardiomyopathy, atrial fibrillation, ischemia during transplantation) both in animal models and humans. Magnetic resonance techniques with both spectroscopy (MRS, 31P, 23Na and 1H) and imaging (MRI) are combined to biochemical analyses and molecular biology methods Experimental models range from the isolated perfused rodent heart model to in vivo rodent models and to humans.

Keywords

  • Metabolism
  • New MR Biomarkers
  • Sodium Homeostatis
  • X-Nuclei
  • Ischemia
  • Diabetes
  • Obesity
  • Transplantation

General Information

Membership on public advisory committees (last ten years)

· Elected Member of the Scientific committee of Medical School of Marseille (since 2006)
· Member of section 28 (imaging, bioengineering, pharmacology) of CNRS Comité National 2012-2021, President from 2016 to 2021.
· Coordinator of the Marseille node for Bioimaging of the National Infrastructure “France Life Imaging” and member of the national steering committee since 2012
· Councillor for the national Institute for health technology (ITMO Technologies pour la santé) since 2012
· Member of the steering committee of Institut Carnot STAR since 2016
· Member of the Scientific committee “Ligue contre le cancer grand ouest” since 2019
· Deputy director of Marseille Imaging Institute since september 2019
· Member of CNRS Health Mirror Group dedicated to Horizon Europe since 2021
·“Chargée de mission” CNRS engineering institute (INSIS) since January 2022

Expertises :

– Member of the National Panel of Experts on Organ Transplantation, INSERM (2007-2009).
– Evaluation of national and international research grants : Programme Hospitalier de Recherche Clinique (PHRC), Agence Nationale de la Recherche (ANR), Agence de la Biomedecine, PEPS projects of CNRS, Hcéres, Ligue contre le Cancer, Région Aquitaine, Ville de Paris, Sorbonne Université, région île de France, CIFRE fellowships, Medical Research Council, Welcome Trust, Diabetes UK (GB), Technology Foundation (Netherlands), Swiss National Foundation, Bridge Discovery (Switzerland), Israel Science Foundation, Research Council KU Leuven (Belgium).

Editorial activity :

– Member of the editorial committee of the journal of the international Society of Magnetic Resonance « Journal of Cardiovascular Magnetic Resonance » (2007-2011).
– Referee for numerous journals (imaging, cardiovascular, generalist)

Publications :

Bernard, M. (2022) ‘Editorial for “Differential Adaptation of Biventricular Myocardial Kinetic Energy in Patients with Repaired Tetralogy of Fallot Assessed by MR Tissue Phase Mapping”’, Journal of magnetic resonance imaging: JMRI [Preprint]. Available at: https://doi.org/10.1002/jmri.28417.
Lezoualc’h, F., Badimon, L., Baker, H., Bernard, M., Czibik, G., de Boer, R.A., D’Humières, T., Kergoat, M., Kowala, M., Rieusset, J., Vilahur, G., Détrait, M., Watson, C. and Derumeaux, G.A. (2022) ‘The need for adjusting experimental models to meet clinical reality’, Cardiovascular Research, p. cvac152. Available at: https://doi.org/10.1093/cvr/cvac152.
Lutz, N.W. and Bernard, M. (2022) ‘Methodological Developments for Metabolic NMR Spectroscopy from Cultured Cells to Tissue Extracts: Achievements, Progress and Pitfalls’, Molecules (Basel, Switzerland), 27(13), p. 4214. Available at: https://doi.org/10.3390/molecules27134214.
Yuan, W.L., Bernard, J.Y., Armand, M., Sarté, C., Charles, M.A. and Heude, B. (2022) ‘Associations of Maternal Consumption of Dairy Products during Pregnancy with Perinatal Fatty Acids Profile in the EDEN Cohort Study’, Nutrients, 14(8), p. 1636. Available at: https://doi.org/10.3390/nu14081636.
Xerri, A., Gallardo, F., Kober, F., Mathieu, C., Fourny, N., Tran, T.T., Mege, J.-L., Singer, M., Lalevée, N., Bernard, M. and Leone, M. (2022) ‘Female hormones prevent sepsis-induced cardiac dysfunction: an experimental randomized study’, Scientific Reports, 12(1), p. 4939. Available at: https://doi.org/10.1038/s41598-022-08889-4.
Daudé, P., Ancel, P., Confort Gouny, S., Jacquier, A., Kober, F., Dutour, A., Bernard, M., Gaborit, B. and Rapacchi, S. (2022) ‘Deep-Learning Segmentation of Epicardial Adipose Tissue Using Four-Chamber Cardiac Magnetic Resonance Imaging’, Diagnostics (Basel, Switzerland), 12(1), p. 126. Available at: https://doi.org/10.3390/diagnostics12010126.
Bernard, M. (2022) ‘Editorial for “Prospective Evaluation of Virtual MR Elastography With Diffusion Weighted Imaging in Subjects With Nonalcoholic Fatty Liver Disease”’, Journal of Magnetic Resonance Imaging, 56(5), pp. 1457–1458. Available at: https://doi.org/10.1002/jmri.28155.
Kober, F. and Bernard, M. (2022) ‘Cardiac In Vivo Magnetic Resonance Spectroscopy’, in G. Roberts and A. Watts (eds) Encyclopedia of Biophysics. Berlin, Heidelberg: Springer, pp. 1–4. Available at: https://doi.org/10.1007/978-3-642-35943-9_10103-1.
Chatel, B., Ducreux, S., Harhous, Z., Bendridi, N., Varlet, I., Ogier, A.C., Bernard, M., Gondin, J., Rieusset, J., Westerblad, H., Bendahan, D. and Gineste, C. (2021) ‘Impaired aerobic capacity and premature fatigue preceding muscle weakness in the skeletal muscle Tfam-knockout mouse model’, Disease Models & Mechanisms, 14(9), p. dmm048981. Available at: https://doi.org/10.1242/dmm.048981.
Fourny, N., Lan, C., Bernard, M. and Desrois, M. (2021) ‘Male and Female Rats Have Different Physiological Response to High-Fat High-Sucrose Diet but Similar Myocardial Sensitivity to Ischemia-Reperfusion Injury’, Nutrients, 13(9), p. 2914. Available at: https://doi.org/10.3390/nu13092914.
Fournel, J., Bartoli, A., Bendahan, D., Guye, M., Bernard, M., Rauseo, E., Khanji, M.Y., Petersen, S.E., Jacquier, A. and Ghattas, B. (2021) ‘Medical image segmentation automatic quality control: A multi-dimensional approach’, Medical Image Analysis, 74, p. 102213. Available at: https://doi.org/10.1016/j.media.2021.102213.
de Winter, J.M., Gineste, C., Minardi, E., Brocca, L., Rossi, M., Borsboom, T., Beggs, A.H., Bernard, M., Bendahan, D., Hwee, D.T., Malik, F.I., Pellegrino, M.A., Bottinelli, R., Gondin, J. and Ottenheijm, C.A.C. (2021) ‘Acute and chronic tirasemtiv treatment improves in vivo and in vitro muscle performance in actin-based nemaline myopathy mice’, Human Molecular Genetics, 30(14), pp. 1305–1320. Available at: https://doi.org/10.1093/hmg/ddab112.
Sourdon, J., Roussel, T., Costes, C., Viout, P., Guye, M., Ranjeva, J.-P., Bernard, M., Kober, F. and Rapacchi, S. (2021) ‘Comparison of single-voxel 1H-cardiovascular magnetic resonance spectroscopy techniques for in vivo measurement of myocardial creatine and triglycerides at 3T’, Journal of Cardiovascular Magnetic Resonance: Official Journal of the Society for Cardiovascular Magnetic Resonance, 23(1), p. 53. Available at: https://doi.org/10.1186/s12968-021-00748-x.
Gaborit, B., Ancel, P., Abdullah, A.E., Maurice, F., Abdesselam, I., Calen, A., Soghomonian, A., Houssays, M., Varlet, I., Eisinger, M., Lasbleiz, A., Peiretti, F., Bornet, C.E., Lefur, Y., Pini, L., Rapacchi, S., Bernard, M., Resseguier, N., Darmon, P., Kober, F. and Dutour, A. (2021) ‘Effect of empagliflozin on ectopic fat stores and myocardial energetics in type 2 diabetes: the EMPACEF study’, Cardiovascular Diabetology, 20(1), p. 57. Available at: https://doi.org/10.1186/s12933-021-01237-2.
Foussier, C., Barral, P.A., Jerosh-Herold, M., Gariboldi, V., Rapacchi, S., Gallon, A., Bartoli, A., Bentatou, Z., Guye, M., Bernard, M. and Jacquier, A. (2021) ‘Quantification of diffuse myocardial fibrosis using CMR extracellular volume fraction and serum biomarkers of collagen turnover with histologic quantification as standard of reference’, Diagnostic and Interventional Imaging, 102(3), pp. 163–169. Available at: https://doi.org/10.1016/j.diii.2020.07.005.
van Rossem, L., Smit, H.A., Armand, M., Bernard, J.Y., Bisgaard, H., Bønnelykke, K., Bruun, S., Heude, B., Husby, S., Kyhl, H.B., Michaelsen, K.F., Stark, K.D., Thijs, C., Vinding, R.K., Wijga, A.H. and Lauritzen, L. (2021) ‘Breast milk n-3 long-chain polyunsaturated fatty acids and blood pressure: an individual participant meta-analysis’, European Journal of Nutrition, 60(2), pp. 989–998. Available at: https://doi.org/10.1007/s00394-020-02310-4.
Bartoli, A., Fournel, J., Bentatou, Z., Habib, G., Lalande, A., Bernard, M., Boussel, L., Pontana, F., Dacher, J.-N., Ghattas, B. and Jacquier, A. (2021) ‘Deep Learning-based Automated Segmentation of Left Ventricular Trabeculations and Myocardium on Cardiac MR Images: A Feasibility Study’, Radiology. Artificial Intelligence, 3(1), p. e200021. Available at: https://doi.org/10.1148/ryai.2020200021.
Fourny, N., Beauloye, C., Bernard, M., Horman, S., Desrois, M. and Bertrand, L. (2021) ‘Sex Differences of the Diabetic Heart’, Frontiers in Physiology, 12, p. 661297. Available at: https://doi.org/10.3389/fphys.2021.661297.
Lutz, N.W. and Bernard, M. (2020) ‘Contactless Thermometry by MRI and MRS: Advanced Methods for Thermotherapy and Biomaterials’, iScience, 23(10), p. 101561. Available at: https://doi.org/10.1016/j.isci.2020.101561.
Capron, T., Cautela, J., Scemama, U., Miola, C., Bartoli, A., Theron, A., Pinto, J., Porto, A., Collart, F., Lepidi, H., Bernard, M., Guye, M., Thuny, F., Avierinos, J.-F. and Jacquier, A. (2020) ‘Cardiac magnetic resonance assessment of left ventricular dilatation in chronic severe left-sided regurgitations: comparison with standard echocardiography’, Diagnostic and Interventional Imaging, 101(10), pp. 657–665. Available at: https://doi.org/10.1016/j.diii.2020.04.014.
Debski, K.J., Ceglia, N., Ghestem, A., Ivanov, A.I., Brancati, G.E., Bröer, S., Bot, A.M., Müller, J.A., Schoch, S., Becker, A., Löscher, W., Guye, M., Sassone-Corsi, P., Lukasiuk, K., Baldi, P. and Bernard, C. (2020) ‘The circadian dynamics of the hippocampal transcriptome and proteome is altered in experimental temporal lobe epilepsy’, Science Advances, 6(41), p. eaat5979. Available at: https://doi.org/10.1126/sciadv.aat5979.
Habert, P., Capron, T., Hubert, S., Bentatou, Z., Bartoli, A., Tradi, F., Renard, S., Rapacchi, S., Guye, M., Bernard, M., Habib, G. and Jacquier, A. (2020) ‘Quantification of right ventricular extracellular volume in pulmonary hypertension using cardiac magnetic resonance imaging’, Diagnostic and Interventional Imaging, 101(5), pp. 311–320. Available at: https://doi.org/10.1016/j.diii.2019.12.008.
Bentatou, Z., Troalen, T., Bernard, M., Guye, M., Pini, L., Bartoli, A., Jacquier, A., Kober, F. and Rapacchi, S. (2020) ‘Simultaneous multi-slice T1 mapping using MOLLI with blipped CAIPIRINHA bSSFP’, Magnetic Resonance Imaging, pp. S0730-725X(19)30796–9. Available at: https://doi.org/10.1016/j.mri.2020.03.006.
Masi, B., Perles-Barbacaru, T.-A., Bernard, M. and Viola, A. (2020) ‘Clinical and Preclinical Imaging of Hepatosplenic Schistosomiasis’, Trends in Parasitology, 36(2), pp. 206–226. Available at: https://doi.org/10.1016/j.pt.2019.11.007.
Guenoun, D., Pithioux, M., Souplet, J.-C., Guis, S., Le Corroller, T., Fouré, A., Pauly, V., Mattei, J.-P., Bernard, M., Guye, M., Chabrand, P., Champsaur, P. and Bendahan, D. (2020) ‘Assessment of proximal femur microarchitecture using ultra-high field MRI at 7 Tesla’, Diagnostic and Interventional Imaging, 101(1), pp. 45–53. Available at: https://doi.org/10.1016/j.diii.2019.06.013.
Abellan Lopez, M., Bertrand, B., Kober, F., Boucekine, M., De Fromont De Bouailles, M., Vogtensperger, M., Bernard, M., Casanova, D., Magalon, J. and Sabatier, F. (2020) ‘The Use of Higher Proportions of Platelet-Rich Plasma to Enrich Microfat Has Negative Effects: A Preclinical Study’, Plastic and Reconstructive Surgery, 145(1), pp. 130–140. Available at: https://doi.org/10.1097/PRS.0000000000006406.
Gineste, C., Ogier, A.C., Varlet, I., Hourani, Z., Bernard, M., Granzier, H., Bendahan, D. and Gondin, J. (2020) ‘In vivo characterization of skeletal muscle function in nebulin-deficient mice’, Muscle & Nerve, 61(3), pp. 416–424. Available at: https://doi.org/10.1002/mus.26798.
Tran, T.T., Mathieu, C., Torres, M., Loriod, B., Lê, L.T., Nguyen, C., Bernard, M., Leone, M. and Lalevée, N. (2019) ‘Effect of landiolol on sex-related transcriptomic changes in the myocardium during sepsis’, Intensive Care Medicine Experimental, 7(1), p. 50. Available at: https://doi.org/10.1186/s40635-019-0263-0.
Vergara Gomez, T.S., Dubois, M., Glybovski, S., Larrat, B., de Rosny, J., Rockstuhl, C., Bernard, M., Abdeddaim, R., Enoch, S. and Kober, F. (2019) ‘Wireless coils based on resonant and nonresonant coupled-wire structure for small animal multinuclear imaging’, NMR in biomedicine, 32(5), p. e4079. Available at: https://doi.org/10.1002/nbm.4079.
Warnez-Soulie, J., Macia, M., Lac, S., Pecchi, E., Bernard, M., Bendahan, D., Bartoli, M., Carrier, A. and Giannesini, B. (2019) ‘Tumor protein 53-induced nuclear protein 1 deficiency alters mouse gastrocnemius muscle function and bioenergetics in vivo’, Physiological Reports, 7(10), p. e14055. Available at: https://doi.org/10.14814/phy2.14055.
Fourny, N., Lan, C., Kober, F., Boulghobra, D., Bresciani, J., Reboul, C., Bernard, M. and Desrois, M. (2019) ‘Cardiac remodeling and higher sensitivity to ischemia-reperfusion injury in female rats submitted to high-fat high-sucrose diet: An in vivo/ex vivo longitudinal follow-up’, The Journal of Nutritional Biochemistry, 69, pp. 139–150. Available at: https://doi.org/10.1016/j.jnutbio.2019.03.022.
Visentin, S., Michel, G., Oudin, C., Cousin, B., Gaborit, B., Abdesselam, I., Maraninchi, M., Nowicki, M., Valéro, R., Guye, M., Bernard, M., Auquier, P., Chambost, H., Alessi, M.-C. and Béliard, S. (2019) ‘Lipodystrophy-like features after total body irradiation among survivors of childhood acute leukemia’, Endocrine Connections, 8(4), pp. 349–359. Available at: https://doi.org/10.1530/EC-18-0497.
Rapacchi, S., Troalen, T., Bentatou, Z., Quemeneur, M., Guye, M., Bernard, M., Jacquier, A. and Kober, F. (2019) ‘Simultaneous multi-slice cardiac cine with Fourier-encoded self-calibration at 7 Tesla’, Magnetic Resonance in Medicine, 81(4), pp. 2576–2587. Available at: https://doi.org/10.1002/mrm.27593.
Wei, W., Evin, M., Rapacchi, S., Kober, F., Bernard, M., Jacquier, A., Kahn, C.J.F. and Behr, M. (2019) ‘Investigating heartbeat-related in-plane motion and stress levels induced at the aortic root’, Biomedical Engineering Online, 18(1), p. 19. Available at: https://doi.org/10.1186/s12938-019-0632-7.
Fourny, N., Lan, C., Sérée, E., Bernard, M. and Desrois, M. (2019) ‘Protective Effect of Resveratrol against Ischemia-Reperfusion Injury via Enhanced High Energy Compounds and eNOS-SIRT1 Expression in Type 2 Diabetic Female Rat Heart’, Nutrients, 11(1), p. E105. Available at: https://doi.org/10.3390/nu11010105.
Lutz, N.W. and Bernard, M. (2019) ‘A method for multiparametric statistical quantification of the heterogeneity of free Na+ concentration by 19 F MR spectroscopy: Proof of principle in silico and in vitro’, NMR in biomedicine, 32(9), p. e4117. Available at: https://doi.org/10.1002/nbm.4117.
Lutz, N.W. and Bernard, M. (2019) ‘Multiparametric statistical quantification of pH heterogeneity by 1H MRS and MRSI of extracellular pH markers: Proof of principle’, NMR in Biomedicine, 32(11), p. e4134. Available at: https://doi.org/10.1002/nbm.4134.
Chatel, B., Messonnier, L.A., Vilmen, C., Bernard, M., Pialoux, V. and Bendahan, D. (2019) ‘Ischaemia-induced muscle metabolic abnormalities are poorly alleviated by endurance training in a mouse model of sickle cell disease’, Experimental Physiology, 104(3), pp. 398–406. Available at: https://doi.org/10.1113/EP087430.