BERNARD Monique

monique.bernard@univ-amu.fr
Phone : +33491324818

Cardiovascular (CVS) imaging team.

Research Director (PhD)
at CNRS

Deputy director CRMBM
Co-head of the cardiovascular team

Download my Resume (FR )

Detailed Activities

My research interests are focused on the study of metabolic, physiological and functional alterations during cardiovascular pathologies related to diffuse or localized ischemia (atherosclerosis, diabetic and obesity related cardiomyopathy, atrial fibrillation, ischemia during transplantation) both in animal models and humans. Magnetic resonance techniques with both spectroscopy (MRS, 31P, 23Na and 1H) and imaging (MRI) are combined to biochemical analyses and molecular biology methods Experimental models range from the isolated perfused rodent heart model to in vivo rodent models and to humans.

Keywords

Metabolism
New MR Biomarkers
Sodium Homeostatis
X-Nuclei

Ischemia
Diabetes
Obesity
Transplantation

General Information

Membership on public advisory committees (last ten years)

· Elected Member of the Scientific committee of Medical School of Marseille (since 2006)
· Member of section 28 (imaging, bioengineering, pharmacology) of CNRS Comité National 2012-2021, President from 2016 to 2021.
· Coordinator of the Marseille node for Bioimaging of the National Infrastructure “France Life Imaging” and member of the national steering committee since 2012
· Councillor for the national Institute for health technology (ITMO Technologies pour la santé) since 2012
· Member of the steering committee of Institut Carnot STAR since 2016
· Member of the Scientific committee “Ligue contre le cancer grand ouest” since 2019
· Deputy director of Marseille Imaging Institute since september 2019
· Member of CNRS Health Mirror Group dedicated to Horizon Europe since 2021
·“Chargée de mission” CNRS engineering institute (INSIS) since January 2022

Expertises :

– Member of the National Panel of Experts on Organ Transplantation, INSERM (2007-2009).
– Evaluation of national and international research grants : Programme Hospitalier de Recherche Clinique (PHRC), Agence Nationale de la Recherche (ANR), Agence de la Biomedecine, PEPS projects of CNRS, Hcéres, Ligue contre le Cancer, Région Aquitaine, Ville de Paris, Sorbonne Université, région île de France, CIFRE fellowships, Medical Research Council, Welcome Trust, Diabetes UK (GB), Technology Foundation (Netherlands), Swiss National Foundation, Bridge Discovery (Switzerland), Israel Science Foundation, Research Council KU Leuven (Belgium).

Editorial activity :

– Member of the editorial committee of the journal of the international Society of Magnetic Resonance « Journal of Cardiovascular Magnetic Resonance » (2007-2011).
– Referee for numerous journals (imaging, cardiovascular, generalist)

Publications :

180164 BERNARD 1 harvard-cite-them-right-no-et-al 50 date desc year 923 https://crmbm.univ-amu.fr/wp-content/plugins/zotpress/

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Abou Assi, A., Armand, M., Sarté, C., Tafflet, M., Yuan, W.L., Peyre, H., Charles, M.-A., Heude, B. and Bernard, J.Y. (2025) “Patterns of perinatal exposure to PUFAs and child neurodevelopment: evidence from Mendelian randomization using FADS cluster variants,” The American Journal of Clinical Nutrition, 122(1), pp. 235–243. Available at: https://doi.org/10.1016/j.ajcnut.2025.03.014.

Jouenne, A., Sourdon, J., Varlet, I., Vilmen, C., Kober, F., Landrier, J.F., Bernard, M. and Desrois, M. (2025) “Resveratrol protection against cardiac remodeling and ischemia-reperfusion injury associated with hepatic lipid metabolism ameliorations and adipose tissue autotaxin pathway inhibition in a diet induced prediabetic female rat model,” The Journal of Nutritional Biochemistry, p. 109992. Available at: https://doi.org/10.1016/j.jnutbio.2025.109992.

Chatel, B., Varlet, I., Ogier, A.C., Pecchi, E., Bernard, M., Gondin, J., Westerblad, H., Bendahan, D. and Gineste, C. (2025) “Cyclosporine A Delays the Terminal Disease Stage in the Tfam KO Mitochondrial Myopathy Mouse Model Without Improving Mitochondrial Energy Production,” Muscle & Nerve, 71(2), pp. 265–274. Available at: https://doi.org/10.1002/mus.28315.

Yuan, W.L., Armand, M., Peyre, H., Sarté, C., Charles, M.A., Heude, B. and Bernard, J.Y. (2024) “Associations between perinatal biomarkers of maternal dairy fat intake and child cognitive development: results from the EDEN mother-child cohort,” European Journal of Clinical Nutrition, pp. 1–9. Available at: https://doi.org/10.1038/s41430-024-01544-3.

Lyu, Z., Ralahy, B., Perles-Barbacaru, T.-A., Ding, L., Jiang, Y., Lian, B., Roussel, T., Liu, Xi, Galanakou, C., Laurini, E., Tintaru, A., Giorgio, S., Pricl, S., Liu, Xiaoxuan, Bernard, M., Iovanna, J., Viola, A. and Peng, L. (2024) “Self-assembling dendrimer nanosystems for specific fluorine magnetic resonance imaging and effective theranostic treatment of tumors,” Proceedings of the National Academy of Sciences of the United States of America, 121(25), p. e2322403121. Available at: https://doi.org/10.1073/pnas.2322403121.

Daudé, P., Troalen, T., Mackowiak, A.L.C., Royer, E., Piccini, D., Yerly, J., Pfeuffer, J., Kober, F., Gouny, S.C., Bernard, M., Stuber, M., Bastiaansen, J.A.M. and Rapacchi, S. (2024) “Trajectory correction enables free-running chemical shift encoded imaging for accurate cardiac proton-density fat fraction quantification at 3T,” Journal of Cardiovascular Magnetic Resonance: Official Journal of the Society for Cardiovascular Magnetic Resonance, p. 101048. Available at: https://doi.org/10.1016/j.jocmr.2024.101048.

Henry, J.A., Abdesselam, I., Deal, O., Lewis, A.J., Rayner, J., Bernard, M., Dutour, A., Gaborit, B., Kober, F., Soghomonian, A., Sgromo, B., Byrne, J., Bege, T., Borlaug, B.A., Neubauer, S. and Rider, O.J. (2024) “The effect of bariatric surgery type on cardiac reverse remodelling,” International Journal of Obesity, 48(6), pp. 808–814. Available at: https://doi.org/10.1038/s41366-024-01474-x.

Abou Assi, A., Heude, B., Plancoulaine, S., Sarté, C., Tafflet, M., Yuan, W.L., Charles, M.-A., Armand, M. and Bernard, J.Y. (2024) “Patterns of perinatal polyunsaturated fatty acid status and associated dietary or candidate-genetic factors,” Journal of Lipid Research, p. 100562. Available at: https://doi.org/10.1016/j.jlr.2024.100562.

Lokossou, H.A., Rabuffo, G., Bernard, M., Bernard, C., Viola, A. and Perles-Barbacaru, T.-A. (2024) “Impact of the day/night cycle on functional connectome in ageing male and female mice,” NeuroImage, p. 120576. Available at: https://doi.org/10.1016/j.neuroimage.2024.120576.

Chopinet, S., Lopez, O., Brustlein, S., Uzel, A., Moyon, A., Varlet, I., Balasse, L., Kober, F., Bobot, M., Bernard, M., Haffner, A., Sdika, M., Montcel, B., Guillet, B., Vidal, V., Grégoire, E., Hardwigsen, J. and Brige, P. (2024) “Comparing Different Methods for the Diagnosis of Liver Steatosis: What Are the Best Diagnostic Tools?,” Diagnostics, 14(20), p. 2292. Available at: https://doi.org/10.3390/diagnostics14202292.

Bernard, M. (2024) “Editorial for ‘Pulmonary Transit Time Derived from First-Pass Perfusion Cardiac MR Imaging: A Potential New Marker for Cardiac Involvement and Prognosis in Light-Chain Amyloidosis,’” Journal of Magnetic Resonance Imaging, 60(3), pp. 1011–1012. Available at: https://doi.org/10.1002/jmri.29136.

Kober, F., Caus, T., Riberi, A., Le Fur, Y. and Bernard, M. (2024) “Time Course of High-Energy Phosphate Depletion During Cold Storage of Human Heart Grafts Using the Celsior Solution,” Transplant International: Official Journal of the European Society for Organ Transplantation, 37, p. 12994. Available at: https://doi.org/10.3389/ti.2024.12994.

Bernard, M. and Kober, F. (2024) “Editorial for ‘Coronary Microvascular Dysfunction and Diffuse Myocardial Fibrosis in Patients with Type 2 Diabetes Using Quantitative Perfusion MRI,’” Journal of Magnetic Resonance Imaging, 60(6), pp. 2407–2408. Available at: https://doi.org/10.1002/jmri.29346.

Daudé, P., Roussel, T., Troalen, T., Viout, P., Hernando, D., Guye, M., Kober, F., Confort Gouny, S., Bernard, M. and Rapacchi, S. (2024) “Comparative review of algorithms and methods for chemical-shift-encoded quantitative fat-water imaging,” Magnetic Resonance in Medicine, 91(2), pp. 741–759. Available at: https://doi.org/10.1002/mrm.29860.

Tessier, A., Ruze, A.J., Varlet, I., Laïb, E.M.H., Royer, E., Bernard, M., Viola, A. and Perles-Barbacaru, T.-A. (2024) “Quantitative MRI of Gd-DOTA Accumulation in the Mouse Brain After Intraperitoneal Administration: Validation by Mass Spectrometry,” Journal of Magnetic Resonance Imaging, 60(1), pp. 316–324. Available at: https://doi.org/10.1002/jmri.29034.

Ding, L., Lyu, Z., Perles-Barbacaru, T.-A., Huang, A.Y.-T., Lian, B., Jiang, Y., Roussel, T., Galanakou, C., Giorgio, S., Kao, C.-L., Liu, X., Iovanna, J., Bernard, M., Viola, A. and Peng, L. (2023) “Modular Self-Assembling Dendrimer Nanosystems for Magnetic Resonance And Multimodality Imaging of Tumors,” Advanced Materials (Deerfield Beach, Fla.), p. e2308262. Available at: https://doi.org/10.1002/adma.202308262.

Jouenne, A., Hamici, K., Varlet, I., Sourdon, J., Daudé, P., Lan, C., Kober, F., Landrier, J.F., Bernard, M. and Desrois, M. (2023) “Relationship of cardiac remodeling and perfusion alteration with hepatic lipid metabolism in a prediabetic high fat high sucrose diet female rat model,” Biochemical and Biophysical Research Communications, 682, pp. 207–215. Available at: https://doi.org/10.1016/j.bbrc.2023.09.089.

Lezoualc’h, F., Badimon, L., Baker, H., Bernard, M., Czibik, G., de Boer, R.A., D’Humières, T., Kergoat, M., Kowala, M., Rieusset, J., Vilahur, G., Détrait, M., Watson, C. and Derumeaux, G.A. (2023) “Diabetic cardiomyopathy: the need for adjusting experimental models to meet clinical reality,” Cardiovascular Research, 119(5), pp. 1130–1145. Available at: https://doi.org/10.1093/cvr/cvac152.

Choquet, C., Sicard, P., Vahdat, J., Nguyen, T.H.M., Kober, F., Varlet, I., Bernard, M., Richard, S., Kelly, R.G., Lalevée, N. and Miquerol, L. (2023) “Nkx2-5 Loss of Function in the His-Purkinje System Hampers Its Maturation and Leads to Mechanical Dysfunction,” Journal of Cardiovascular Development and Disease, 10(5), p. 194. Available at: https://doi.org/10.3390/jcdd10050194.

Dollomaja, B., Makhalova, J., Wang, H., Bartolomei, F., Jirsa, V. and Bernard, C. (2023) “Personalized whole brain modeling of status epilepticus,” Epilepsy & Behavior: E&B, 142, p. 109175. Available at: https://doi.org/10.1016/j.yebeh.2023.109175.

Cadour, F., Quemeneur, M., Biere, L., Donal, E., Bentatou, Z., Eicher, J.-C., Roubille, F., Lalande, A., Giorgi, R., Rapacchi, S., Cortaredona, S., Tradi, F., Bartoli, A., Willoteaux, S., Delahaye, F., Biene, S.M., Mangin, L., Ferrier, N., Dacher, J.-N., Bauer, F., Leurent, G., Lentz, P.-A., Kovacsik, H., Croisille, P., Thuny, F., Bernard, M., Guye, M., Furber, A., Habib, G. and Jacquier, A. (2023) “Prognostic value of cardiovascular magnetic resonance T1 mapping and extracellular volume fraction in nonischemic dilated cardiomyopathy,” Journal of Cardiovascular Magnetic Resonance: Official Journal of the Society for Cardiovascular Magnetic Resonance, 25(1), p. 7. Available at: https://doi.org/10.1186/s12968-023-00919-y.

Pons, N., Fernández-Eulate, G., Pegat, A., Théaudin, M., Guieu, R., Ripellino, P., Devedjian, M., Mace, P., Masingue, M., Léonard-Louis, S., Petiot, P., Roche, P., Bernard, E., Bouhour, F., Good, J.-M., Verschueren, A., Grapperon, A.-M., Salort, E., Grosset, A., Chanson, J.-B., Nadaj-Pakleza, A., Bédat-Millet, A.-L., Choumert, A., Barnier, A., Hamdi, G., Lesca, G., Prieur, F., Bruneel, A., Latour, P., Stojkovic, T., Attarian, S. and Bonello-Palot, N. (2023) “SORD-related peripheral neuropathy in a French and Swiss cohort: Clinical features, genetic analyses, and sorbitol dosages,” European Journal of Neurology, 30(7), pp. 2001–2011. Available at: https://doi.org/10.1111/ene.15793.

Henry, J.A., Abdesselam, I., Deal, O., Lewis, A.J., Rayner, J., Bernard, M., Dutour, A., Gaborit, B., Kober, F., Soghomonian, A., Sgromo, B., Byrne, J., Bege, T., Neubauer, S., Borlaug, B.A. and Rider, O.J. (2023) “Changes in epicardial and visceral adipose tissue depots following bariatric surgery and their effect on cardiac geometry,” Frontiers in Endocrinology, 14, p. 1092777. Available at: https://doi.org/10.3389/fendo.2023.1092777.

Soghomonian, A., Dutour, A., Kachenoura, N., Thuny, F., Lasbleiz, A., Ancel, P., Cristofari, R., Jouve, E., Simeoni, U., Kober, F., Bernard, M. and Gaborit, B. (2023) “Is increased myocardial triglyceride content associated with early changes in left ventricular function? A 1H-MRS and MRI strain study,” Frontiers in Endocrinology, 14, p. 1181452. Available at: https://doi.org/10.3389/fendo.2023.1181452.

Bernard, M. (2023) “Editorial for ‘Differential Adaptation of Biventricular Myocardial Kinetic Energy in Patients with Repaired Tetralogy of Fallot Assessed by MR Tissue Phase Mapping,’” Journal of Magnetic Resonance Imaging, 57(5), pp. 1505–1506. Available at: https://doi.org/10.1002/jmri.28417.

Lutz, N.W. and Bernard, M. (2022) “Methodological Developments for Metabolic NMR Spectroscopy from Cultured Cells to Tissue Extracts: Achievements, Progress and Pitfalls,” Molecules (Basel, Switzerland), 27(13), p. 4214. Available at: https://doi.org/10.3390/molecules27134214.

Yuan, W.L., Bernard, J.Y., Armand, M., Sarté, C., Charles, M.A. and Heude, B. (2022) “Associations of Maternal Consumption of Dairy Products during Pregnancy with Perinatal Fatty Acids Profile in the EDEN Cohort Study,” Nutrients, 14(8), p. 1636. Available at: https://doi.org/10.3390/nu14081636.

Xerri, A., Gallardo, F., Kober, F., Mathieu, C., Fourny, N., Tran, T.T., Mege, J.-L., Singer, M., Lalevée, N., Bernard, M. and Leone, M. (2022) “Female hormones prevent sepsis-induced cardiac dysfunction: an experimental randomized study,” Scientific Reports, 12(1), p. 4939. Available at: https://doi.org/10.1038/s41598-022-08889-4.

Daudé, P., Ancel, P., Confort Gouny, S., Jacquier, A., Kober, F., Dutour, A., Bernard, M., Gaborit, B. and Rapacchi, S. (2022) “Deep-Learning Segmentation of Epicardial Adipose Tissue Using Four-Chamber Cardiac Magnetic Resonance Imaging,” Diagnostics (Basel, Switzerland), 12(1), p. 126. Available at: https://doi.org/10.3390/diagnostics12010126.

Bernard, M. (2022) “Editorial for ‘Prospective Evaluation of Virtual MR Elastography With Diffusion Weighted Imaging in Subjects With Nonalcoholic Fatty Liver Disease,’” Journal of Magnetic Resonance Imaging, 56(5), pp. 1457–1458. Available at: https://doi.org/10.1002/jmri.28155.

Kober, F. and Bernard, M. (2022) “Cardiac In Vivo Magnetic Resonance Spectroscopy,” Encyclopedia of Biophysics. Edited by G. Roberts and A. Watts. Berlin, Heidelberg: Springer. Available at: https://doi.org/10.1007/978-3-642-35943-9_10103-1.

Chatel, B., Ducreux, S., Harhous, Z., Bendridi, N., Varlet, I., Ogier, A.C., Bernard, M., Gondin, J., Rieusset, J., Westerblad, H., Bendahan, D. and Gineste, C. (2021) “Impaired aerobic capacity and premature fatigue preceding muscle weakness in the skeletal muscle Tfam-knockout mouse model,” Disease Models & Mechanisms, 14(9), p. dmm048981. Available at: https://doi.org/10.1242/dmm.048981.

Fourny, N., Lan, C., Bernard, M. and Desrois, M. (2021) “Male and Female Rats Have Different Physiological Response to High-Fat High-Sucrose Diet but Similar Myocardial Sensitivity to Ischemia-Reperfusion Injury,” Nutrients, 13(9), p. 2914. Available at: https://doi.org/10.3390/nu13092914.

Fournel, J., Bartoli, A., Bendahan, D., Guye, M., Bernard, M., Rauseo, E., Khanji, M.Y., Petersen, S.E., Jacquier, A. and Ghattas, B. (2021) “Medical image segmentation automatic quality control: A multi-dimensional approach,” Medical Image Analysis, 74, p. 102213. Available at: https://doi.org/10.1016/j.media.2021.102213.

de Winter, J.M., Gineste, C., Minardi, E., Brocca, L., Rossi, M., Borsboom, T., Beggs, A.H., Bernard, M., Bendahan, D., Hwee, D.T., Malik, F.I., Pellegrino, M.A., Bottinelli, R., Gondin, J. and Ottenheijm, C.A.C. (2021) “Acute and chronic tirasemtiv treatment improves in vivo and in vitro muscle performance in actin-based nemaline myopathy mice,” Human Molecular Genetics, 30(14), pp. 1305–1320. Available at: https://doi.org/10.1093/hmg/ddab112.

Sourdon, J., Roussel, T., Costes, C., Viout, P., Guye, M., Ranjeva, J.-P., Bernard, M., Kober, F. and Rapacchi, S. (2021) “Comparison of single-voxel 1H-cardiovascular magnetic resonance spectroscopy techniques for in vivo measurement of myocardial creatine and triglycerides at 3T,” Journal of Cardiovascular Magnetic Resonance: Official Journal of the Society for Cardiovascular Magnetic Resonance, 23(1), p. 53. Available at: https://doi.org/10.1186/s12968-021-00748-x.

Gaborit, B., Ancel, P., Abdullah, A.E., Maurice, F., Abdesselam, I., Calen, A., Soghomonian, A., Houssays, M., Varlet, I., Eisinger, M., Lasbleiz, A., Peiretti, F., Bornet, C.E., Lefur, Y., Pini, L., Rapacchi, S., Bernard, M., Resseguier, N., Darmon, P., Kober, F. and Dutour, A. (2021) “Effect of empagliflozin on ectopic fat stores and myocardial energetics in type 2 diabetes: the EMPACEF study,” Cardiovascular Diabetology, 20(1), p. 57. Available at: https://doi.org/10.1186/s12933-021-01237-2.

Foussier, C., Barral, P.A., Jerosh-Herold, M., Gariboldi, V., Rapacchi, S., Gallon, A., Bartoli, A., Bentatou, Z., Guye, M., Bernard, M. and Jacquier, A. (2021) “Quantification of diffuse myocardial fibrosis using CMR extracellular volume fraction and serum biomarkers of collagen turnover with histologic quantification as standard of reference,” Diagnostic and Interventional Imaging, 102(3), pp. 163–169. Available at: https://doi.org/10.1016/j.diii.2020.07.005.

van Rossem, L., Smit, H.A., Armand, M., Bernard, J.Y., Bisgaard, H., Bønnelykke, K., Bruun, S., Heude, B., Husby, S., Kyhl, H.B., Michaelsen, K.F., Stark, K.D., Thijs, C., Vinding, R.K., Wijga, A.H. and Lauritzen, L. (2021) “Breast milk n-3 long-chain polyunsaturated fatty acids and blood pressure: an individual participant meta-analysis,” European Journal of Nutrition, 60(2), pp. 989–998. Available at: https://doi.org/10.1007/s00394-020-02310-4.

Bartoli, A., Fournel, J., Bentatou, Z., Habib, G., Lalande, A., Bernard, M., Boussel, L., Pontana, F., Dacher, J.-N., Ghattas, B. and Jacquier, A. (2021) “Deep Learning-based Automated Segmentation of Left Ventricular Trabeculations and Myocardium on Cardiac MR Images: A Feasibility Study,” Radiology. Artificial Intelligence, 3(1), p. e200021. Available at: https://doi.org/10.1148/ryai.2020200021.

Fourny, N., Beauloye, C., Bernard, M., Horman, S., Desrois, M. and Bertrand, L. (2021) “Sex Differences of the Diabetic Heart,” Frontiers in Physiology, 12, p. 661297. Available at: https://doi.org/10.3389/fphys.2021.661297.

Lutz, N.W. and Bernard, M. (2020) “Contactless Thermometry by MRI and MRS: Advanced Methods for Thermotherapy and Biomaterials,” iScience, 23(10), p. 101561. Available at: https://doi.org/10.1016/j.isci.2020.101561.