Brain Imaging

Research Works

Principal investigator : Wafaa Zaaraoui

The brain imaging group aims at developing new MR biomarkers at high (3T) and ultra-high (7T) fields to characterize the anatomy, the microstructure, the meso-scale network organization, the metabolism and the homeostasis of the brain. The objectives are to push forward the limits of brain imaging using the added value of UHF MRI and counteracting the pitfalls, focusing on improved spatial resolution to characterize anatomy and function of complex small size gray matter structures or cortical layers. We also contribute to the advances of multimodal UHF MRI to characterize brain connectivity, and we work at rendering UHF X-nuclei MRI/MRSI usable in clinical compatible protocols.

Group Members:

• Leader: Wafaa Zaaraoui (CR CNRS)
• Jean-Philippe Ranjeva (PR Neurosciences)
• Maxime Guye (PU-PH Biophysics, AMU/APHM)
• Adil Maarouf (MCU-PH, Neurology, AMU/APHM)
• Jan-Patrick Stellmann (MCU-PH, Radiology, AMU/APHM)
• Aude-Marie Grapperon (PH Neurology, APHM)
• Yann le Fur (IR CNRS)
• Hugo Dary (IR CNRS)

Post-Doctoral researchers :

• Penelope TILSLEY
• Tangi Roussel
• Mohamed Mounir El MENDILI
• Roy Haast

PhD students :

• Kushboo PENJABI
• Coleen ROGER
• Maëva Cotinat
• Lucas Gauer

Representative Publications

Automatic segmentation of deep grey nuclei using a high-resolution 7Tmagnetic resonance imaging atlas-Quantification of T1 values in healthy volunteers. Brun G, Testud B, Girard OM, Lehmann P, de Rochefort L, Besson P, Massire A, Ridley B, Girard N, Guye M, Ranjeva JP, Le Troter A.Eur J Neurosci. 2022 Jan;55(2):438-460. doi: 10.1111/ejn.15575. Epub 2022 Jan 7.

Dynamic ²³Na MRI – A non-invasive window on neuroglial-vascular mechanisms underlying brain function. Bydder M, Zaaraoui W, Ridley B, Soubrier M, Bertinetti M, Confort-Gouny S, Schad L, Guye M, Ranjeva JP.Neuroimage. 2019 Jan 1;184:771-780. doi: 10.1016/j.neuroimage.2018.09.071.

Distribution of brain sodium long and short relaxation times and concentrations: a multi-echo ultra-high field ²³Na MRI study. Ridley B, Nagel AM, Bydder M, Maarouf A, Stellmann JP, Gherib S, Verneuil J, Viout P, Guye M, Ranjeva JP, Zaaraoui W.Sci Rep. 2018 Mar 12;8(1):4357. doi: 10.1038/s41598-018-22711-0.

Evidencing different neurochemical profiles between thalamic nuclei using high resolution 2D-PRESS semi-LASER (1)H-MRSI at 7 T. Donadieu M, Le Fur Y, Confort-Gouny S, Le Troter A, Guye M, Ranjeva JP.MAGMA. 2016 Jun;29(3):491-501. doi: 10.1007/s10334-016-0556-1. Epub 2016 Apr 8.

An optimized MP2RAGE sequence for studying both brain and cervical spinal cord in a single acquisition at 3T. Forodighasemabadi A, Rasoanandrianina H, El Mendili MM, Guye M, Callot V.Magn Reson Imaging. 2021 Dec;84:18-26. doi: 10.1016/j.mri.2021.08.011. Epub 2021 Sep 10.

Brain Networks are Independently Modulated by Donepezil, Sleep, and Sleep Deprivation. Wirsich J, Rey M, Guye M, Bénar C, Lanteaume L, Ridley B, Confort-Gouny S, Cassé-Perrot C, Soulier E, Viout P, Rouby F, Lefebvre MN, Audebert C, Truillet R, Jouve E, Payoux P, Bartrés-Faz D, Bordet R, Richardson JC, Babiloni C, Rossini PM, Micallef J, Blin O, Ranjeva JP; Pharmacog Consortium.Brain Topogr. 2018 May;31(3):380-391. doi: 10.1007/s10548-017-0608-5. Epub 2017 Nov 23.

Specific brain activation patterns associated with two neuromuscular electrical stimulation protocols. Wegrzyk J, Ranjeva JP, Fouré A, Kavounoudias A, Vilmen C, Mattei JP, Guye M, Maffiuletti NA, Place N, Bendahan D, Gondin J.Sci Rep. 2017 Jun 2;7(1):2742. doi: 10.1038/s41598-017-03188-9.