This toolbox is dedicated to model fitting and simulation for Intra-Voxel Incoherent Motion (IVIM) MR imaging. It gathers tools, on the one hand, to fit IVIM bi-exponential signal representation voxel-wise and, on the other hand, to run Monte Carlo simulations in order to assess the estimation error on parameters as well as to calculate the minimum required SNR to get accurate estimation.

This technique was primarily developed the context of Spinal Cord MR imaging, but can be used to optimize any IVIM applications.

The toolbox is freely available. It is part of Simon Lévy’s PhD work at CRMBM-CEMEREM. It received funding from the European Union’s Horizon 2020 research and innovation program (Marie Skłodowska-Curie grant agreement #713750), the Regional Council of Provence-Alpes-Côte d’Azur, A*MIDEX (#ANR-11-IDEX-0001-02, #7T-AMI-ANR-11-EQPX-0001, #A*MIDEX-EI-13-07-130115-08.38-7T-AMISTART) and CNRS (Centre National de la Recherche Scientifique).

Please cite the following reference when using the IVIM-Toolbox:
S.Lévy, S. Rapacchi, T.Troalen, M. Guye, V. Callot, Intra-Voxel Incoherent Motion at 7T to quantify human spinal cord microperfusion: pitfalls and promises, Magn Reson Med. 2020, 84(3):1198-1217. https://doi.org/10.1002/mrm.28195

A dataset of IVIM MRI acquired in the spinal cord of a healthy volunteer as published in the reference above is provided for testing.