NGUYEN Phi-ho

Technician

Publications :

180164 NGUYEN 1 harvard-cite-them-right-no-et-al 50 date desc year 5635 https://crmbm.univ-amu.fr/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22RJRHRZJ6%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Bouazizi%20et%20al.%22%2C%22parsedDate%22%3A%222025-08-12%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BBouazizi%2C%20K.%2C%20Yoganathan%2C%20T.%2C%20Kober%2C%20F.%2C%20Autret%2C%20G.%2C%20Marsac%2C%20P.%2C%20Delacroix%2C%20C.%2C%20Soulez%2C%20S.%2C%20Zarai%2C%20M.%2C%20Nguyen%2C%20V.%2C%20Squalli%2C%20A.%2C%20Alayrac%2C%20P.%2C%20Robidel%2C%20E.%2C%20Tavitian%2C%20B.%2C%20Redheuil%2C%20A.%2C%20Hulot%2C%20J.-S.%20and%20Kachenoura%2C%20N.%20%282025%29%20%26%23x201C%3BLeft%20ventricle%20strain%20and%20T1%20mapping%20evaluation%20in%20a%20mouse%20model%20with%20myocardial%20infarction%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BScientific%20Reports%26lt%3B%5C%2Fi%26gt%3B%2C%2015%281%29%2C%20p.%2029579.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-025-09699-0%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-025-09699-0%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Left%20ventricle%20strain%20and%20T1%20mapping%20evaluation%20in%20a%20mouse%20model%20with%20myocardial%20infarction%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Khaoula%22%2C%22lastName%22%3A%22Bouazizi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thulaciga%22%2C%22lastName%22%3A%22Yoganathan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Frank%22%2C%22lastName%22%3A%22Kober%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gwennhael%22%2C%22lastName%22%3A%22Autret%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Perrine%22%2C%22lastName%22%3A%22Marsac%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cl%5Cu00e9ment%22%2C%22lastName%22%3A%22Delacroix%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shannon%22%2C%22lastName%22%3A%22Soulez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mohamed%22%2C%22lastName%22%3A%22Zarai%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%22%2C%22lastName%22%3A%22Nguyen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Adil%22%2C%22lastName%22%3A%22Squalli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Paul%22%2C%22lastName%22%3A%22Alayrac%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Estelle%22%2C%22lastName%22%3A%22Robidel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bertrand%22%2C%22lastName%22%3A%22Tavitian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alban%22%2C%22lastName%22%3A%22Redheuil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-S%5Cu00e9bastien%22%2C%22lastName%22%3A%22Hulot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadjia%22%2C%22lastName%22%3A%22Kachenoura%22%7D%5D%2C%22abstractNote%22%3A%22Myocardial%20strain%20and%20T1%20mapping%20offer%20precise%20evaluation%20of%20cardiac%20function%20and%20tissue%20characteristics.%20The%20aim%20of%20this%20study%20is%20to%20provide%20normative%20myocardial%20strain%20and%20T1%20values%20in%20mice%20model%20along%20with%20their%20changes%20after%20myocardial%20infarction%20%28MI%29%20using%20a%20tailored%20acquisition%20and%20analysis%20protocol.%20Healthy%20mice%20had%20MRI%20before%20and%20after%20MI.%20Imaging%20was%20performed%20to%20assess%20cardiac%20function%20and%20left%20ventricle%20%28LV%29%20strain.%20A%20Look-Locker%20Inversion-Recovery%20sequence%20was%20used%20for%20T1%20maps%20reconstruction.%20Gadolinium%20doses%20and%20timing%20of%20image%20acquisitions%20were%20optimized.%20Radial%20and%20circumferential%20strain%20measurements%20were%20conducted%20using%20a%20custom%20software%20based%20on%20feature%20tracking.%20To%20address%20ECG%20signal%20interference%2C%20adjustments%20were%20made%20for%20accurate%20strain%20calculations.%20An%20LV%20dilation%20in%20MI%20compared%20to%20wild-type%20%28WT%29%20with%20a%20decrease%20in%20LV%20ejection%20fraction%20%28p%5Cu2009%26lt%3B%5Cu20090.0001%29%20were%20reported%20while%20stroke%20volume%20and%20cardiac%20output%20remained%20preserved%20%28p%5Cu2009%26gt%3B%5Cu20090.21%29.%20Normative%20strain%20and%20T1%20mapping%20data%20were%20provided%20revealing%20an%20increase%20in%20circumferential%20strain%20from%20base%20to%20apex%20%28basal%3A%20-14%5Cu2009%5Cu00b1%5Cu20091%25%2C%20mid%3A%20-15%5Cu2009%5Cu00b1%5Cu20092%25%2C%20apical%3A%20-%2021%5Cu2009%5Cu00b1%5Cu20093%25%3B%5Cu00a0p%5Cu2009%26lt%3B%5Cu20090.0001%29%20and%20notable%20differences%20in%20native%20and%20post-contrast%20T1%20values%20between%20mid-ventricular%20and%20apical%20LV%20segments.%20Circumferential%20strain%20differences%20between%20MI%20and%20WT%20mice%20were%20pronounced%2C%20with%20a%20significant%20drop%20in%20apical%20strain%20%28p%5Cu2009%26lt%3B%5Cu20090.0001%29%20in%20MI.%20Post-MI%20mice%20exhibited%20higher%20native%20T1%20and%20lower%20post-contrast%20T1%20compared%20to%20WT.%20Our%20methodological%20approach%20not%20only%20refines%20imaging%20sequences%20but%20also%20offers%20insights%20into%20cardiac%20function%20and%20tissue%20characteristics%20in%20mice.%20By%20describing%20normative%20values%20of%20strain%20and%20T1%2C%20our%20findings%20lay%20the%20groundwork%20for%20future%20research%2C%20particularly%20in%20drug%20therapy.%22%2C%22date%22%3A%222025-08-12%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41598-025-09699-0%22%2C%22ISSN%22%3A%222045-2322%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22BR9D2SS4%22%5D%2C%22dateModified%22%3A%222025-11-19T13%3A59%3A28Z%22%7D%7D%2C%7B%22key%22%3A%229PJB43IK%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Choquet%20et%20al.%22%2C%22parsedDate%22%3A%222023-05%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BChoquet%2C%20C.%2C%20Sicard%2C%20P.%2C%20Vahdat%2C%20J.%2C%20Nguyen%2C%20T.H.M.%2C%20Kober%2C%20F.%2C%20Varlet%2C%20I.%2C%20Bernard%2C%20M.%2C%20Richard%2C%20S.%2C%20Kelly%2C%20R.G.%2C%20Lalev%26%23xE9%3Be%2C%20N.%20and%20Miquerol%2C%20L.%20%282023%29%20%26%23x201C%3BNkx2-5%20Loss%20of%20Function%20in%20the%20His-Purkinje%20System%20Hampers%20Its%20Maturation%20and%20Leads%20to%20Mechanical%20Dysfunction%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BJournal%20of%20Cardiovascular%20Development%20and%20Disease%26lt%3B%5C%2Fi%26gt%3B%2C%2010%285%29%2C%20p.%20194.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3390%5C%2Fjcdd10050194%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3390%5C%2Fjcdd10050194%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Nkx2-5%20Loss%20of%20Function%20in%20the%20His-Purkinje%20System%20Hampers%20Its%20Maturation%20and%20Leads%20to%20Mechanical%20Dysfunction%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Caroline%22%2C%22lastName%22%3A%22Choquet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pierre%22%2C%22lastName%22%3A%22Sicard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Juliette%22%2C%22lastName%22%3A%22Vahdat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thi%20Hong%20Minh%22%2C%22lastName%22%3A%22Nguyen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Frank%22%2C%22lastName%22%3A%22Kober%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Isabelle%22%2C%22lastName%22%3A%22Varlet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Monique%22%2C%22lastName%22%3A%22Bernard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylvain%22%2C%22lastName%22%3A%22Richard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robert%20G.%22%2C%22lastName%22%3A%22Kelly%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nathalie%22%2C%22lastName%22%3A%22Lalev%5Cu00e9e%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lucile%22%2C%22lastName%22%3A%22Miquerol%22%7D%5D%2C%22abstractNote%22%3A%22The%20ventricular%20conduction%20or%20His-Purkinje%20system%20%28VCS%29%20mediates%20the%20rapid%20propagation%20and%20precise%20delivery%20of%20electrical%20activity%20essential%20for%20the%20synchronization%20of%20heartbeats.%20Mutations%20in%20the%20transcription%20factor%20Nkx2-5%20have%20been%20implicated%20in%20a%20high%20prevalence%20of%20developing%20ventricular%20conduction%20defects%20or%20arrhythmias%20with%20age.%20Nkx2-5%20heterozygous%20mutant%20mice%20reproduce%20human%20phenotypes%20associated%20with%20a%20hypoplastic%20His-Purkinje%20system%20resulting%20from%20defective%20patterning%20of%20the%20Purkinje%20fiber%20network%20during%20development.%20Here%2C%20we%20investigated%20the%20role%20of%20Nkx2-5%20in%20the%20mature%20VCS%20and%20the%20consequences%20of%20its%20loss%20on%20cardiac%20function.%20Neonatal%20deletion%20of%20Nkx2-5%20in%20the%20VCS%20using%20a%20Cx40-CreERT2%20mouse%20line%20provoked%20apical%20hypoplasia%20and%20maturation%20defects%20of%20the%20Purkinje%20fiber%20network.%20Genetic%20tracing%20analysis%20demonstrated%20that%20neonatal%20Cx40-positive%20cells%20fail%20to%20maintain%20a%20conductive%20phenotype%20after%20Nkx2-5%20deletion.%20Moreover%2C%20we%20observed%20a%20progressive%20loss%20of%20expression%20of%20fast-conduction%20markers%20in%20persistent%20Purkinje%20fibers.%20Consequently%2C%20Nkx2-5-deleted%20mice%20developed%20conduction%20defects%20with%20progressively%20reduced%20QRS%20amplitude%20and%20RSR%5Cu2019%20complex%20associated%20with%20higher%20duration.%20Cardiac%20function%20recorded%20by%20MRI%20revealed%20a%20reduction%20in%20the%20ejection%20fraction%20in%20the%20absence%20of%20morphological%20changes.%20With%20age%2C%20these%20mice%20develop%20a%20ventricular%20diastolic%20dysfunction%20associated%20with%20dyssynchrony%20and%20wall-motion%20abnormalities%20without%20indication%20of%20fibrosis.%20These%20results%20highlight%20the%20requirement%20of%20postnatal%20expression%20of%20Nkx2-5%20in%20the%20maturation%20and%20maintenance%20of%20a%20functional%20Purkinje%20fiber%20network%20to%20preserve%20contraction%20synchrony%20and%20cardiac%20function.%22%2C%22date%22%3A%222023%5C%2F5%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.3390%5C%2Fjcdd10050194%22%2C%22ISSN%22%3A%222308-3425%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.mdpi.com%5C%2F2308-3425%5C%2F10%5C%2F5%5C%2F194%22%2C%22collections%22%3A%5B%225Z6CVJGB%22%2C%22BR9D2SS4%22%5D%2C%22dateModified%22%3A%222025-04-15T07%3A49%3A30Z%22%7D%7D%2C%7B%22key%22%3A%2269NBKADM%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Donghi%20et%20al.%22%2C%22parsedDate%22%3A%222020-05%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BDonghi%2C%20V.%2C%20Tradi%2C%20F.%2C%20Carbone%2C%20A.%2C%20Viala%2C%20M.%2C%20Gaubert%2C%20G.%2C%20Nguyen%2C%20K.%2C%20Reant%2C%20P.%2C%20Donal%2C%20E.%2C%20Eicher%2C%20J.-C.%2C%20Selton-Suty%2C%20C.%2C%20Huttin%2C%20O.%2C%20Resseguier%2C%20N.%2C%20Michel%2C%20N.%2C%20Guazzi%2C%20M.%2C%20Jacquier%2C%20A.%20and%20Habib%2C%20G.%20%282020%29%20%26%23x201C%3BLeft-ventricular%20non-compaction-comparison%20between%20different%20techniques%20of%20quantification%20of%20trabeculations%3A%20Should%20the%20diagnostic%20thresholds%20be%20modified%3F%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BArchives%20of%20Cardiovascular%20Diseases%26lt%3B%5C%2Fi%26gt%3B%2C%20113%285%29%2C%20pp.%20321%26%23x2013%3B331.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.acvd.2020.01.004%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.acvd.2020.01.004%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Left-ventricular%20non-compaction-comparison%20between%20different%20techniques%20of%20quantification%20of%20trabeculations%3A%20Should%20the%20diagnostic%20thresholds%20be%20modified%3F%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Valeria%22%2C%22lastName%22%3A%22Donghi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Farouk%22%2C%22lastName%22%3A%22Tradi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreina%22%2C%22lastName%22%3A%22Carbone%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marie%22%2C%22lastName%22%3A%22Viala%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guillaume%22%2C%22lastName%22%3A%22Gaubert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karine%22%2C%22lastName%22%3A%22Nguyen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Patricia%22%2C%22lastName%22%3A%22Reant%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Erwan%22%2C%22lastName%22%3A%22Donal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Christophe%22%2C%22lastName%22%3A%22Eicher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christine%22%2C%22lastName%22%3A%22Selton-Suty%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Olivier%22%2C%22lastName%22%3A%22Huttin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Noemie%22%2C%22lastName%22%3A%22Resseguier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Michel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marco%22%2C%22lastName%22%3A%22Guazzi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexis%22%2C%22lastName%22%3A%22Jacquier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gilbert%22%2C%22lastName%22%3A%22Habib%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Diagnosis%20of%20left%20ventricular%20non-compaction%20%28LVNC%29%20is%20challenging%2C%20and%20different%20imaging%20techniques%20propose%20different%20criteria.%5CnAIM%3A%20To%20compare%20the%20value%20of%20two-dimensional%20transthoracic%20echocardiography%20%282D-TTE%29%20and%20cardiac%20magnetic%20resonance%20%28CMR%29%20criteria%20in%20diagnosing%20LVNC%2C%20and%20to%20test%20a%20new%20trabecular%20quantification%20method%20obtained%20by%202D-TTE%2C%20exploring%20its%20relationship%20with%20CMR%20non-compacted%20mass%20quantification.%5CnMETHODS%3A%20From%20a%20multicentre%20French%20study%2C%20we%20selected%2048%20patients%20with%20LVNC%20and%2020%20with%20dilated%20cardiomyopathy%20%28DCM%29%20who%20underwent%202D-TTE%20and%20CMR.%20Current%202D-TTE%20%28Jenni%20et%20al.%29%20and%20CMR%20criteria%20%28Petersen%20et%20al.%2C%20Jacquier%20et%20al.%29%2C%20were%20tested.%20A%20new%202D-TTE%20method%20of%20trabecular%20quantification%20%28percentage%20of%20trabecular%20area%29%20was%20also%20proposed%2C%20and%20compared%20with%20current%20criteria.%5CnRESULTS%3A%20The%20best%20cut-off%20values%20for%20the%20diagnosis%20of%20LVNC%20were%20a%20non-compacted%5C%2Fcompacted%20ratio%5Cu22652.3%20%28Petersen%20et%20al.%29%2C%20a%20trabeculated%20left%20ventricular%20mass%5Cu226520%25%20%28Jacquier%20et%20al.%29%20and%20a%20non-compacted%5C%2Fcompacted%20ratio%5Cu22651.8%20%28Jenni%20et%20al.%29.%20Lowering%20the%20threshold%20for%20the%20criterion%20of%20Jenni%20et%20al.%20from%26gt%3B2%20to%20%5Cu22651.8%20improved%20its%20sensitivity%20from%2069%25%20to%2098%25.%20The%202D-TTE%20percentage%20of%20trabecular%20area%20was%2025.9%5Cu00b18%25%20in%20the%20LVNC%20group%20vs.%209.9%5Cu00b14.4%25%20in%20the%20DCM%20group%20%28P%26lt%3B0.05%29%2C%20and%20was%20well%20correlated%20with%20CMR%20non-compacted%20mass%20%28r%3D0.65%3B%20P%26lt%3B0.05%29.%20A%2015.8%25%20threshold%20value%20for%202D-TTE%20percentage%20of%20trabecular%20area%20predicted%20LVNC%20diagnosis%20with%20a%20specificity%20of%2095%25%20and%20a%20sensitivity%20of%2092%25%3B%20its%20sensitivity%20was%20better%20than%20that%20for%20the%20criteria%20of%20Jenni%20et%20al.%20%28P%26lt%3B0.01%29%20and%20Petersen%20et%20al.%20%28P%3D0.03%29.%5CnCONCLUSIONS%3A%20Revision%20of%20the%20current%20threshold%20for%20the%20criterion%20of%20Jenni%20et%20al.%20from%26gt%3B2%20to%20%5Cu22651.8%20is%20necessary%20to%20improve%20LVNC%20diagnosis%20in%20patients%20with%20left%20ventricular%20dysfunction.%20A%20new%202D-TTE%20trabecular%20quantification%20method%20improves%20TTE%20diagnosis%20of%20LVNC.%22%2C%22date%22%3A%222020-05%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.acvd.2020.01.004%22%2C%22ISSN%22%3A%221875-2128%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22KFZ6H27M%22%2C%22XTA6KS7L%22%2C%22TXRC8BWU%22%5D%2C%22dateModified%22%3A%222025-02-05T09%3A07%3A59Z%22%7D%7D%2C%7B%22key%22%3A%22HNYV2CT5%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Tran%20et%20al.%22%2C%22parsedDate%22%3A%222019-08-19%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BTran%2C%20T.T.%2C%20Mathieu%2C%20C.%2C%20Torres%2C%20M.%2C%20Loriod%2C%20B.%2C%20L%26%23xEA%3B%2C%20L.T.%2C%20Nguyen%2C%20C.%2C%20Bernard%2C%20M.%2C%20Leone%2C%20M.%20and%20Lalev%26%23xE9%3Be%2C%20N.%20%282019%29%20%26%23x201C%3BEffect%20of%20landiolol%20on%20sex-related%20transcriptomic%20changes%20in%20the%20myocardium%20during%20sepsis%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BIntensive%20Care%20Medicine%20Experimental%26lt%3B%5C%2Fi%26gt%3B%2C%207%281%29%2C%20p.%2050.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs40635-019-0263-0%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs40635-019-0263-0%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Effect%20of%20landiolol%20on%20sex-related%20transcriptomic%20changes%20in%20the%20myocardium%20during%20sepsis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thi%20Thom%22%2C%22lastName%22%3A%22Tran%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Calypso%22%2C%22lastName%22%3A%22Mathieu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Magali%22%2C%22lastName%22%3A%22Torres%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B%5Cu00e9atrice%22%2C%22lastName%22%3A%22Loriod%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Linh%20Thuy%22%2C%22lastName%22%3A%22L%5Cu00ea%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Catherine%22%2C%22lastName%22%3A%22Nguyen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Monique%22%2C%22lastName%22%3A%22Bernard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marc%22%2C%22lastName%22%3A%22Leone%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nathalie%22%2C%22lastName%22%3A%22Lalev%5Cu00e9e%22%7D%5D%2C%22abstractNote%22%3A%22OBJECTIVES%3A%20The%20aims%20of%20this%20study%20are%20to%20better%20understand%20phenotypic%20differences%20between%20male%20and%20female%20rats%20during%20sepsis%2C%20to%20characterise%20the%20contribution%20of%20the%20beta1-adrenergic%20blocker%20landiolol%20to%20septic%20cardiomyopathy%20and%20to%20determine%20why%20landiolol%20induces%20divergent%20effects%20in%20males%20and%20females.%5CnMETHODS%3A%20The%20myocardial%20transcriptional%20profiles%20in%20male%20and%20female%20Wistar%20rats%20were%20assessed%20after%20the%20induction%20of%20sepsis%20by%20cecal%20ligation%20and%20puncture%20and%20addition%20of%20landiolol.%5CnRESULTS%3A%20Our%20results%20showed%20major%20differences%20in%20the%20biological%20processes%20activated%20during%20sepsis%20in%20male%20and%20female%20rats.%20In%20particular%2C%20a%20significant%20decrease%20in%20processes%20related%20to%20cell%20organisation%2C%20contractile%20function%2C%20ionic%20transport%20and%20phosphoinositide-3-kinase%5C%2FAKT%20%28PI3K%5C%2FAKT%29%20signalling%20was%20observed%20only%20in%20males.%20The%20transcript%20of%20ATPase%20sarcoplasmic%5C%2Fendoplasmic%20reticulum%20Ca2%2B%20transporting%203%20%28SERCA3%29%20was%20sex-differently%20regulated.%20In%20males%2C%20landiolol%20reversed%20several%20signalling%20pathways%20dysregulated%20during%20sepsis.%20The%20expression%20level%20of%20genes%20encoding%20tubulin%20alpha%208%20%28TUBA8%29%20and%20myosin%20heavy%20chain%207B%20%28MYH7%29%20contractile%20proteins%2C%20phosphatase%202%20catalytic%20subunit%20alpha%20%28PPP2CA%29%2C%20G%20protein-coupled%20receptor%20kinase%205%20%28GRK5%29%20and%20A-kinase%20anchoring%20protein%206%20%28AKAP6%29%20returned%20to%20their%20basal%20levels.%20In%20contrast%2C%20in%20females%2C%20landiolol%20had%20limited%20effects.%5CnCONCLUSION%3A%20In%20males%2C%20landiolol%20reversed%20the%20expression%20of%20many%20genes%20that%20were%20deregulated%20in%20sepsis.%20Conversely%2C%20sepsis-induced%20deregulation%20of%20gene%20expression%20was%20less%20pronounced%20in%20females%20than%20in%20males%2C%20and%20was%20maintained%20in%20the%20landiolol-treated%20females.%20These%20findings%20highlight%20important%20sex-related%20differences%20and%20confirm%20previous%20observations%20on%20the%20important%20benefit%20of%20landiolol%20intake%20on%20cardiac%20function%20in%20male%20rats.%22%2C%22date%22%3A%22Aug%2019%2C%202019%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1186%5C%2Fs40635-019-0263-0%22%2C%22ISSN%22%3A%222197-425X%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%225Z6CVJGB%22%2C%22XTA6KS7L%22%5D%2C%22dateModified%22%3A%222022-02-24T14%3A33%3A53Z%22%7D%7D%2C%7B%22key%22%3A%22A98PWFQ2%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Choquet%20et%20al.%22%2C%22parsedDate%22%3A%222018-07%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BChoquet%2C%20C.%2C%20Nguyen%2C%20T.H.M.%2C%20Sicard%2C%20P.%2C%20Buttigieg%2C%20E.%2C%20Tran%2C%20T.T.%2C%20Kober%2C%20F.%2C%20Varlet%2C%20I.%2C%20Sturny%2C%20R.%2C%20Costa%2C%20M.W.%2C%20Harvey%2C%20R.P.%2C%20Nguyen%2C%20C.%2C%20Rihet%2C%20P.%2C%20Richard%2C%20S.%2C%20Bernard%2C%20M.%2C%20Kelly%2C%20R.G.%2C%20Lalev%26%23xE9%3Be%2C%20N.%20and%20Miquerol%2C%20L.%20%282018%29%20%26%23x201C%3BDeletion%20of%20Nkx2-5%20in%20trabecular%20myocardium%20reveals%20the%20developmental%20origins%20of%20pathological%20heterogeneity%20associated%20with%20ventricular%20non-compaction%20cardiomyopathy%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BPLoS%20genetics%26lt%3B%5C%2Fi%26gt%3B%2C%2014%287%29%2C%20p.%20e1007502.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pgen.1007502%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pgen.1007502%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Deletion%20of%20Nkx2-5%20in%20trabecular%20myocardium%20reveals%20the%20developmental%20origins%20of%20pathological%20heterogeneity%20associated%20with%20ventricular%20non-compaction%20cardiomyopathy%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Caroline%22%2C%22lastName%22%3A%22Choquet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thi%20Hong%20Minh%22%2C%22lastName%22%3A%22Nguyen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pierre%22%2C%22lastName%22%3A%22Sicard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emeline%22%2C%22lastName%22%3A%22Buttigieg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thi%20Thom%22%2C%22lastName%22%3A%22Tran%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Frank%22%2C%22lastName%22%3A%22Kober%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Isabelle%22%2C%22lastName%22%3A%22Varlet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rachel%22%2C%22lastName%22%3A%22Sturny%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mauro%20W.%22%2C%22lastName%22%3A%22Costa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Richard%20P.%22%2C%22lastName%22%3A%22Harvey%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Catherine%22%2C%22lastName%22%3A%22Nguyen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pascal%22%2C%22lastName%22%3A%22Rihet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylvain%22%2C%22lastName%22%3A%22Richard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Monique%22%2C%22lastName%22%3A%22Bernard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robert%20G.%22%2C%22lastName%22%3A%22Kelly%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nathalie%22%2C%22lastName%22%3A%22Lalev%5Cu00e9e%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lucile%22%2C%22lastName%22%3A%22Miquerol%22%7D%5D%2C%22abstractNote%22%3A%22Left%20ventricular%20non-compaction%20%28LVNC%29%20is%20a%20rare%20cardiomyopathy%20associated%20with%20a%20hypertrabeculated%20phenotype%20and%20a%20large%20spectrum%20of%20symptoms.%20It%20is%20still%20unclear%20whether%20LVNC%20results%20from%20a%20defect%20of%20ventricular%20trabeculae%20development%20and%20the%20mechanistic%20basis%20that%20underlies%20the%20varying%20severity%20of%20this%20pathology%20is%20unknown.%20To%20investigate%20these%20issues%2C%20we%20inactivated%20the%20cardiac%20transcription%20factor%20Nkx2-5%20in%20trabecular%20myocardium%20at%20different%20stages%20of%20trabecular%20morphogenesis%20using%20an%20inducible%20Cx40-creERT2%20allele.%20Conditional%20deletion%20of%20Nkx2-5%20at%20embryonic%20stages%2C%20during%20trabecular%20formation%2C%20provokes%20a%20severe%20hypertrabeculated%20phenotype%20associated%20with%20subendocardial%20fibrosis%20and%20Purkinje%20fiber%20hypoplasia.%20A%20milder%20phenotype%20was%20observed%20after%20Nkx2-5%20deletion%20at%20fetal%20stages%2C%20during%20trabecular%20compaction.%20A%20longitudinal%20study%20of%20cardiac%20function%20in%20adult%20Nkx2-5%20conditional%20mutant%20mice%20demonstrates%20that%20excessive%20trabeculation%20is%20associated%20with%20complex%20ventricular%20conduction%20defects%2C%20progressively%20leading%20to%20strain%20defects%2C%20and%2C%20in%2050%25%20of%20mutant%20mice%2C%20to%20heart%20failure.%20Progressive%20impaired%20cardiac%20function%20correlates%20with%20conduction%20and%20strain%20defects%20independently%20of%20the%20degree%20of%20hypertrabeculation.%20Transcriptomic%20analysis%20of%20molecular%20pathways%20reflects%20myocardial%20remodeling%20with%20a%20larger%20number%20of%20differentially%20expressed%20genes%20in%20the%20severe%20versus%20mild%20phenotype%20and%20identifies%20Six1%20as%20being%20upregulated%20in%20hypertrabeculated%20hearts.%20Our%20results%20provide%20insights%20into%20the%20etiology%20of%20LVNC%20and%20link%20its%20pathogenicity%20with%20compromised%20trabecular%20development%20including%20compaction%20defects%20and%20ventricular%20conduction%20system%20hypoplasia.%22%2C%22date%22%3A%22Jul%202018%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1371%5C%2Fjournal.pgen.1007502%22%2C%22ISSN%22%3A%221553-7404%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%225Z6CVJGB%22%2C%22XTA6KS7L%22%2C%22BR9D2SS4%22%5D%2C%22dateModified%22%3A%222025-04-15T07%3A49%3A28Z%22%7D%7D%2C%7B%22key%22%3A%22ARQQ6W7R%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Zhou%20et%20al.%22%2C%22parsedDate%22%3A%222017-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BZhou%2C%20Z.%2C%20Han%2C%20F.%2C%20Rapacchi%2C%20S.%2C%20Nguyen%2C%20K.-L.%2C%20Brunengraber%2C%20D.Z.%2C%20Kim%2C%20G.-H.J.%2C%20Finn%2C%20J.P.%20and%20Hu%2C%20P.%20%282017%29%20%26%23x201C%3BAccelerated%20ferumoxytol-enhanced%204D%20multiphase%2C%20steady-state%20imaging%20with%20contrast%20enhancement%20%28MUSIC%29%20cardiovascular%20MRI%3A%20validation%20in%20pediatric%20congenital%20heart%20disease%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BNMR%20in%20biomedicine%26lt%3B%5C%2Fi%26gt%3B%2C%2030%281%29.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fnbm.3663%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fnbm.3663%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Accelerated%20ferumoxytol-enhanced%204D%20multiphase%2C%20steady-state%20imaging%20with%20contrast%20enhancement%20%28MUSIC%29%20cardiovascular%20MRI%3A%20validation%20in%20pediatric%20congenital%20heart%20disease%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ziwu%22%2C%22lastName%22%3A%22Zhou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fei%22%2C%22lastName%22%3A%22Han%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stanislas%22%2C%22lastName%22%3A%22Rapacchi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kim-Lien%22%2C%22lastName%22%3A%22Nguyen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniel%20Z.%22%2C%22lastName%22%3A%22Brunengraber%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Grace-Hyun%20J.%22%2C%22lastName%22%3A%22Kim%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%20Paul%22%2C%22lastName%22%3A%22Finn%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Peng%22%2C%22lastName%22%3A%22Hu%22%7D%5D%2C%22abstractNote%22%3A%22The%20purpose%20of%20this%20work%20was%20to%20validate%20a%20parallel%20imaging%20%28PI%29%20and%20compressed%20sensing%20%28CS%29%20combined%20reconstruction%20method%20for%20a%20recently%20proposed%204D%20non-breath-held%2C%20multiphase%2C%20steady-state%20imaging%20technique%20%28MUSIC%29%20cardiovascular%20MRI%20in%20a%20cohort%20of%20pediatric%20congenital%20heart%20disease%20patients.%20We%20implemented%20a%20graphics%20processing%20unit%20accelerated%20CS-PI%20combined%20reconstruction%20method%20and%20applied%20it%20in%2013%20pediatric%20patients%20who%20underwent%20cardiovascular%20MRI%20after%20ferumoxytol%20administration.%20Conventional%20breath-held%20contrast-enhanced%20magnetic%20resonance%20angiography%20%28CE-MRA%29%20was%20first%20performed%20during%20the%20first%20pass%20of%20ferumoxytol%20injection%2C%20followed%20by%20the%20original%20MUSIC%20and%20the%20proposed%20CS-PI%20MUSIC%20during%20the%20steady-state%20distribution%20phase%20of%20ferumoxytol.%20Qualities%20of%20acquired%20images%20were%20then%20evaluated%20using%20a%20four-point%20scale.%20Left%20ventricular%20volumes%20and%20ejection%20fractions%20calculated%20from%20the%20original%20MUSIC%20and%20the%20CS-PI%20MUSIC%20were%20also%20compared%20with%20conventional%20multi-slice%202D%20cardiac%20cine%20MRI.%20The%20proposed%20CS-PI%20MUSIC%20reduced%20the%20imaging%20time%20of%20the%20MUSIC%20acquisition%20to%204.6%5Cu00a0%5Cu00b1%5Cu00a00.4%5Cu00a0min%20from%208.9%5Cu00a0%5Cu00b1%5Cu00a01.2%5Cu00a0min.%20Computationally%20intensive%20image%20reconstruction%20was%20completed%20within%205%5Cu00a0min%20without%20interruption%20of%20sequential%20clinical%20scans.%20The%20proposed%20method%20%28mean%203.3-4.0%29%20provided%20image%20quality%20comparable%20to%20that%20of%20the%20original%20MUSIC%20%283.2-4.0%29%20%28all%20P%5Cu00a0%5Cu2265%5Cu00a00.42%29%2C%20and%20better%20than%20conventional%20breath-held%20first-pass%20CE-MRA%20%281.1-3.3%29%20for%2013%20anatomical%20structures%20%28all%20P%20%5Cu2264%200.0014%29%20with%20good%20inter-observer%20agreement%20%28%5Cu03ba%5Cu00a0%26gt%3B%5Cu00a00.46%29.%20The%20calculated%20ventricular%20volumes%20and%20ejection%20fractions%20from%20both%20original%20MUSIC%20%28r%5Cu00a0%26gt%3B%5Cu00a00.90%29%20and%20CS-PI%20MUSIC%20%28r%5Cu00a0%26gt%3B%5Cu00a00.85%29%20correlated%20well%20with%202D%20cine%20imaging.%20In%20conclusion%2C%20PI%20and%20CS%20were%20successfully%20incorporated%20into%20the%204D%20MUSIC%20acquisition%20to%20further%20reduce%20scan%20time%20by%20approximately%2050%25%20while%20maintaining%20highly%20comparable%20image%20quality%20in%20a%20clinically%20practical%20reconstruction%20time.%22%2C%22date%22%3A%22Jan%202017%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1002%5C%2Fnbm.3663%22%2C%22ISSN%22%3A%221099-1492%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22SK6VWU7K%22%2C%22XTA6KS7L%22%5D%2C%22dateModified%22%3A%222024-06-14T08%3A28%3A55Z%22%7D%7D%2C%7B%22key%22%3A%22BH6K98GC%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Shao%20et%20al.%22%2C%22parsedDate%22%3A%222016-02%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BShao%2C%20J.%2C%20Rapacchi%2C%20S.%2C%20Nguyen%2C%20K.-L.%20and%20Hu%2C%20P.%20%282016%29%20%26%23x201C%3BMyocardial%20T1%20mapping%20at%203.0%20tesla%20using%20an%20inversion%20recovery%20spoiled%20gradient%20echo%20readout%20and%20bloch%20equation%20simulation%20with%20slice%20profile%20correction%20%28BLESSPC%29%20T1%20estimation%20algorithm%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BJournal%20of%20magnetic%20resonance%20imaging%3A%20JMRI%26lt%3B%5C%2Fi%26gt%3B%2C%2043%282%29%2C%20pp.%20414%26%23x2013%3B425.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjmri.24999%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjmri.24999%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Myocardial%20T1%20mapping%20at%203.0%20tesla%20using%20an%20inversion%20recovery%20spoiled%20gradient%20echo%20readout%20and%20bloch%20equation%20simulation%20with%20slice%20profile%20correction%20%28BLESSPC%29%20T1%20estimation%20algorithm%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jiaxin%22%2C%22lastName%22%3A%22Shao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stanislas%22%2C%22lastName%22%3A%22Rapacchi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kim-Lien%22%2C%22lastName%22%3A%22Nguyen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Peng%22%2C%22lastName%22%3A%22Hu%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20To%20develop%20an%20accurate%20and%20precise%20myocardial%20T1%20mapping%20technique%20using%20an%20inversion%20recovery%20spoiled%20gradient%20echo%20readout%20at%203.0%20Tesla%20%28T%29.%5CnTHEORY%20AND%20METHODS%3A%20The%20modified%20Look-Locker%20inversion-recovery%20%28MOLLI%29%20sequence%20was%20modified%20to%20use%20fast%20low%20angle%20shot%20%28FLASH%29%20readout%2C%20incorporating%20a%20BLESSPC%20%28Bloch%20Equation%20Simulation%20with%20Slice%20Profile%20Correction%29%20T1%20estimation%20algorithm%2C%20for%20accurate%20myocardial%20T1%20mapping.%20The%20FLASH-MOLLI%20with%20BLESSPC%20fitting%20was%20compared%20with%20different%20approaches%20and%20sequences%20with%20regards%20to%20T1%20estimation%20accuracy%2C%20precision%20and%20image%20artifact%20based%20on%20simulation%2C%20phantom%20studies%2C%20and%20in%20vivo%20studies%20of%2010%20healthy%20volunteers%20and%20three%20patients%20at%203.0%20Tesla.%5CnRESULTS%3A%20The%20FLASH-MOLLI%20with%20BLESSPC%20fitting%20yields%20accurate%20T1%20estimation%20%28average%20error%5Cu2009%3D%5Cu2009-5.4%5Cu2009%5Cu00b1%5Cu200915.1%20ms%2C%20percentage%20error%5Cu2009%3D%5Cu2009-0.5%25%5Cu2009%5Cu00b1%5Cu20091.2%25%29%20for%20T1%20from%20236-1852%20ms%20and%20heart%20rate%20from%2040-100%20bpm%20in%20phantom%20studies.%20The%20FLASH-MOLLI%20sequence%20prevented%20off-resonance%20artifacts%20in%20all%2010%20healthy%20volunteers%20at%203.0T.%20In%20vivo%2C%20there%20was%20no%20significant%20difference%20between%20FLASH-MOLLI-derived%20myocardial%20T1%20values%20and%20%26quot%3BShMOLLI%2BIE%26quot%3B%20derived%20values%20%281458.9%5Cu2009%5Cu00b1%5Cu200920.9%20ms%20versus%201464.1%5Cu2009%5Cu00b1%5Cu20096.8%20ms%2C%20P%5Cu2009%3D%5Cu20090.50%29%3B%20However%2C%20the%20average%20precision%20by%20FLASH-MOLLI%20was%20significantly%20better%20than%20that%20generated%20by%20%26quot%3BShMOLLI%2BIE%26quot%3B%20%281.84%5Cu2009%5Cu00b1%5Cu20090.36%25%20variance%20versus%203.57%5Cu2009%5Cu00b1%5Cu20090.94%25%2C%20P%5Cu2009%26lt%3B%5Cu20090.001%29.%5CnCONCLUSION%3A%20The%20FLASH-MOLLI%20with%20BLESSPC%20fitting%20yields%20accurate%20and%20precise%20T1%20estimation%2C%20and%20eliminates%20banding%20artifacts%20associated%20with%20bSSFP%20at%203.0T.%20J.%20Magn.%20Reson.%20Imaging%202016%3B43%3A414-425.%22%2C%22date%22%3A%22Feb%202016%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1002%5C%2Fjmri.24999%22%2C%22ISSN%22%3A%221522-2586%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22SK6VWU7K%22%2C%22XTA6KS7L%22%5D%2C%22dateModified%22%3A%222016-03-29T15%3A00%3A36Z%22%7D%7D%2C%7B%22key%22%3A%22AXUKPKQH%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Han%20et%20al.%22%2C%22parsedDate%22%3A%222015-08-04%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BHan%2C%20F.%2C%20Zhou%2C%20Z.%2C%20Rapacchi%2C%20S.%2C%20Nguyen%2C%20K.-L.%2C%20Finn%2C%20J.P.%20and%20Hu%2C%20P.%20%282015%29%20%26%23x201C%3BSegmented%20golden%20ratio%20radial%20reordering%20with%20variable%20temporal%20resolution%20for%20dynamic%20cardiac%20MRI%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BMagnetic%20Resonance%20in%20Medicine%26lt%3B%5C%2Fi%26gt%3B%20%5BPreprint%5D.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fmrm.25861%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fmrm.25861%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Segmented%20golden%20ratio%20radial%20reordering%20with%20variable%20temporal%20resolution%20for%20dynamic%20cardiac%20MRI%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fei%22%2C%22lastName%22%3A%22Han%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ziwu%22%2C%22lastName%22%3A%22Zhou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stanislas%22%2C%22lastName%22%3A%22Rapacchi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kim-Lien%22%2C%22lastName%22%3A%22Nguyen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%20Paul%22%2C%22lastName%22%3A%22Finn%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Peng%22%2C%22lastName%22%3A%22Hu%22%7D%5D%2C%22abstractNote%22%3A%22PURPOSE%3A%20Golden%20ratio%20%28GR%29%20radial%20reordering%20allows%20for%20retrospective%20choice%20of%20temporal%20resolution%20by%20providing%20a%20near-uniform%20k-space%20sampling%20within%20any%20reconstruction%20window.%20However%2C%20when%20applying%20GR%20to%20electrocardiogram%20%28ECG%29-gated%20cardiac%20imaging%2C%20the%20k-space%20coverage%20may%20not%20be%20as%20uniform%20because%20a%20single%20reconstruction%20window%20is%20broken%20into%20several%20temporally%20isolated%20ones.%20The%20goal%20of%20this%20study%20was%20to%20investigate%20the%20image%20artifacts%20caused%20by%20applying%20GR%20to%20ECG-gated%20cardiac%20imaging%20and%20to%20propose%20a%20segmented%20GR%20method%20to%20address%20this%20issue.%5CnMETHODS%3A%20Computer%20simulation%20and%20phantom%20experiments%20were%20used%20to%20evaluate%20the%20image%20artifacts%20resulting%20from%20three%20k-space%20sampling%20patterns%20%28ie%2C%20uniform%20radial%2C%20conventional%20GR%2C%20and%20segmented%20GR%29.%20Two-%20and%20three-dimensional%20cardiac%20cine%20images%20were%20acquired%20in%20seven%20healthy%20subjects.%20Imaging%20artifacts%20due%20to%20k-space%20sampling%20nonuniformity%20were%20graded%20on%20a%205-point%20scale%20by%20an%20experienced%20cardiac%20imaging%20reader.%5CnRESULTS%3A%20Segmented%20GR%20provides%20more%20uniform%20k-space%20sampling%20that%20is%20independent%20of%20heart-rate%20variation%20than%20conventional%20GR.%20Cardiac%20cine%20images%20using%20segmented%20GR%20have%20significantly%20higher%20and%20more%20reliable%20image%20quality%20than%20conventional%20GR.%5CnCONCLUSION%3A%20Segmented%20GR%20successfully%20addresses%20the%20nonuniform%20sampling%20that%20occurs%20with%20combining%20conventional%20GR%20with%20ECG%20gating.%20This%20technique%20can%20potentially%20be%20applied%20to%20any%20ECG-gated%20cardiac%20imaging%20application%20to%20allow%20for%20retrospective%20selection%20of%20a%20reconstruction%20window.%20Magn%20Reson%20Med%2C%202015.%20%5Cu00a9%202015%20Wiley%20Periodicals%2C%20Inc.%22%2C%22date%22%3A%22Aug%204%2C%202015%22%2C%22language%22%3A%22ENG%22%2C%22DOI%22%3A%2210.1002%5C%2Fmrm.25861%22%2C%22ISSN%22%3A%221522-2594%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22SK6VWU7K%22%2C%22XTA6KS7L%22%5D%2C%22dateModified%22%3A%222022-02-26T13%3A09%3A43Z%22%7D%7D%2C%7B%22key%22%3A%228ZKX6Q8R%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Cheung%20et%20al.%22%2C%22parsedDate%22%3A%222014-03%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BCheung%2C%20P.P.%2C%20Dougados%2C%20M.%2C%20Andre%2C%20V.%2C%20Balandraud%2C%20N.%2C%20Chal%26%23xE8%3Bs%2C%20G.%2C%20Chary-Valckenaere%2C%20I.%2C%20Dernis%2C%20E.%2C%20Gill%2C%20G.%2C%20Gilson%2C%20M.%2C%20Guis%2C%20S.%2C%20Mouterde%2C%20G.%2C%20Pavy%2C%20S.%2C%20Pouyol%2C%20F.%2C%20Marhadour%2C%20T.%2C%20Richette%2C%20P.%2C%20Ruyssen-Witrand%2C%20A.%2C%20Soubrier%2C%20M.%2C%20Nguyen%2C%20M.%20and%20Gossec%2C%20L.%20%282014%29%20%26%23x201C%3BThe%20learning%20curve%20of%20nurses%20for%20the%20assessment%20of%20swollen%20and%20tender%20joints%20in%20rheumatoid%20arthritis%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BJoint%2C%20Bone%2C%20Spine%3A%20Revue%20Du%20Rhumatisme%26lt%3B%5C%2Fi%26gt%3B%2C%2081%282%29%2C%20pp.%20154%26%23x2013%3B159.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jbspin.2013.06.006%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jbspin.2013.06.006%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22The%20learning%20curve%20of%20nurses%20for%20the%20assessment%20of%20swollen%20and%20tender%20joints%20in%20rheumatoid%20arthritis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Peter%20P.%22%2C%22lastName%22%3A%22Cheung%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maxime%22%2C%22lastName%22%3A%22Dougados%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%22%2C%22lastName%22%3A%22Andre%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nathalie%22%2C%22lastName%22%3A%22Balandraud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G%5Cu00e9rard%22%2C%22lastName%22%3A%22Chal%5Cu00e8s%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Isabelle%22%2C%22lastName%22%3A%22Chary-Valckenaere%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Dernis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ghislaine%22%2C%22lastName%22%3A%22Gill%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Melanie%22%2C%22lastName%22%3A%22Gilson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sandrine%22%2C%22lastName%22%3A%22Guis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gael%22%2C%22lastName%22%3A%22Mouterde%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephan%22%2C%22lastName%22%3A%22Pavy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Francois%22%2C%22lastName%22%3A%22Pouyol%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thierry%22%2C%22lastName%22%3A%22Marhadour%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pascal%22%2C%22lastName%22%3A%22Richette%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Adeline%22%2C%22lastName%22%3A%22Ruyssen-Witrand%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Martin%22%2C%22lastName%22%3A%22Soubrier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Minh%22%2C%22lastName%22%3A%22Nguyen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laure%22%2C%22lastName%22%3A%22Gossec%22%7D%5D%2C%22abstractNote%22%3A%22OBJECTIVES%3A%20In%20rheumatoid%20arthritis%20%28RA%29%2C%20nurses%20are%20now%20increasingly%20involved%20in%20joint%20count%20assessment%20but%20training%20is%20not%20standardized.%20The%20aim%20was%20to%20evaluate%20and%20describe%20the%20learning%20curve%20of%20nurses%20for%20the%20assessment%20of%20swollen%20and%20tender%20joints%20in%20RA.%5CnMETHOD%3A%20Twenty%20nurses%20from%20university%20rheumatology%20centres%20inexperienced%20with%20joint%20counts%20were%20allocated%20to%20a%20rheumatologist%20from%20their%20centre%20%28teacher%29.%20Acquisition%20of%20skills%20consisted%20of%20Phase%201%3A%20%28training%29%2C%20a%20centralized%204hour%20training%20session%2C%20with%20%28a%29%20lecture%20and%20demonstration%2C%20and%20%28b%29%20practical%20sessions%20on%20patients%20with%20their%20teachers%2C%20followed%20by%20Phase%202%3A%20%28practice%29%20involving%20further%20practice%20on%2020%20patients%20in%20their%20own%20hospitals.%20Primary%20outcome%20was%20achievement%20of%20adequate%20swollen%20joint%20agreement%20between%20nurse%20and%20their%20teacher%20%28%26quot%3Bgold%20standard%26quot%3B%29%20at%20the%20%26quot%3Bjoint%26quot%3B%20level%20defined%20by%20prevalence%20adjusted%20biased%20adjusted%20kappa%20%28PABAK%29%26gt%3B0.60.%20Agreement%20at%20the%20%26quot%3Bpatient%26quot%3B%20level%20of%20swollen%20joint%20count%20%28SJC%29%2C%20tender%20joint%20count%20%28TJC%29%20as%20well%20as%20DAS28%20between%20nurse%20and%20their%20teacher%20were%20assessed%20with%20intra-class%20correlation%20coefficients%20%28ICC%29.%5CnRESULTS%3A%20During%20the%20training%20phase%2C%2075%25%20of%20nurses%20achieved%20a%20swollen%20joint%20PABAK%26gt%3B0.60%20when%20compared%20with%20their%20teachers%2C%20which%20further%20improved%20to%2089%25%20after%20the%2020%20practice%20patients%20%28Phase%202%29.%20Median%20swollen%20joint%20PABAK%20improved%20from%200.64%20%28Q1%3AQ3%200.55%2C0.86%29%20to%200.83%20%28Q1%3AQ3%200.77%2C1%29%20by%20the%20end%20of%20Phase%202.%20At%20the%20%26quot%3Bpatient%26quot%3B%20level%2C%20SJC%20agreement%20remained%20globally%20stable%20%28ICC%2C%200.52%20to%200.66%29%2C%20while%20TJC%20and%20DAS28%20agreement%20remained%20excellent%20throughout.%5CnCONCLUSION%3A%20Nurses%20inexperienced%20in%20joint%20counts%20were%20able%20to%20achieve%20excellent%20agreement%20with%20their%20teachers%20in%20assessment%20of%20tender%20and%20swollen%20joints%20through%20a%20short%20training%20session%3B%20practice%20further%20enhanced%20this%20agreement.%20Larger%20longitudinal%20studies%20are%20required%20to%20assess%20skills%20retention.%22%2C%22date%22%3A%22Mar%202014%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.jbspin.2013.06.006%22%2C%22ISSN%22%3A%221778-7254%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%226BEMAGEW%22%2C%22XTA6KS7L%22%5D%2C%22dateModified%22%3A%222024-10-29T10%3A45%3A37Z%22%7D%7D%2C%7B%22key%22%3A%22QPV6UTA3%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22de%20Rochefort%20et%20al.%22%2C%22parsedDate%22%3A%222008-12%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3Bde%20Rochefort%2C%20L.%2C%20Nguyen%2C%20T.%2C%20Brown%2C%20R.%2C%20Spincemaille%2C%20P.%2C%20Choi%2C%20G.%2C%20Weinsaft%2C%20J.%2C%20Prince%2C%20M.R.%20and%20Wang%2C%20Y.%20%282008%29%20%26%23x201C%3BIn%20vivo%20quantification%20of%20contrast%20agent%20concentration%20using%20the%20induced%20magnetic%20field%20for%20time-resolved%20arterial%20input%20function%20measurement%20with%20MRI%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BMedical%20Physics%26lt%3B%5C%2Fi%26gt%3B%2C%2035%2812%29%2C%20pp.%205328%26%23x2013%3B5339.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1118%5C%2F1.3002309%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1118%5C%2F1.3002309%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22In%20vivo%20quantification%20of%20contrast%20agent%20concentration%20using%20the%20induced%20magnetic%20field%20for%20time-resolved%20arterial%20input%20function%20measurement%20with%20MRI%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ludovic%22%2C%22lastName%22%3A%22de%20Rochefort%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thanh%22%2C%22lastName%22%3A%22Nguyen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ryan%22%2C%22lastName%22%3A%22Brown%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pascal%22%2C%22lastName%22%3A%22Spincemaille%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Grace%22%2C%22lastName%22%3A%22Choi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jonathan%22%2C%22lastName%22%3A%22Weinsaft%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Martin%20R.%22%2C%22lastName%22%3A%22Prince%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yi%22%2C%22lastName%22%3A%22Wang%22%7D%5D%2C%22abstractNote%22%3A%22For%20pharmacokinetic%20modeling%20of%20tissue%20physiology%2C%20there%20is%20great%20interest%20in%20measuring%20the%20arterial%20input%20function%20%28AIF%29%20from%20dynamic%20contrast-enhanced%20%28DCE%29%20magnetic%20resonance%20imaging%20%28MRI%29%20using%20paramagnetic%20contrast%20agents.%20Due%20to%20relaxation%20effects%2C%20the%20measured%20signal%20is%20a%20nonlinear%20function%20of%20the%20injected%20contrast%20agent%20concentration%20and%20depends%20on%20sequence%20parameters%2C%20system%20calibration%2C%20and%20time-of-flight%20effects%2C%20making%20it%20difficult%20to%20accurately%20measure%20the%20AIF%20during%20the%20first%20pass.%20Paramagnetic%20contrast%20agents%20also%20affect%20susceptibility%20and%20modify%20the%20magnetic%20field%20in%20proportion%20to%20their%20concentration.%20This%20information%20is%20contained%20in%20the%20MR%20signal%20phase%20which%20is%20discarded%20in%20a%20typical%20image%20reconstruction.%20However%2C%20quantifying%20AIF%20through%20contrast%20agent%20susceptibility%20induced%20phase%20changes%20is%20made%20difficult%20by%20the%20fact%20that%20the%20induced%20magnetic%20field%20is%20nonlocal%20and%20depends%20upon%20the%20contrast%20agent%20spatial%20distribution%20and%20thus%20on%20organ%20and%20vessel%20shapes.%20In%20this%20article%2C%20the%20contrast%20agent%20susceptibility%20was%20quantified%20through%20inversion%20of%20magnetic%20field%20shifts%20using%20a%20piece-wise%20constant%20model.%20Its%20feasibility%20is%20demonstrated%20by%20a%20determination%20of%20the%20AIF%20from%20the%20susceptibility-induced%20field%20changes%20of%20an%20intravenous%20bolus.%20After%20in%20vitro%20validation%2C%20a%20time-resolved%20two-dimensional%20%282D%29%20gradient%20echo%20scan%2C%20triggered%20to%20diastole%2C%20was%20performed%20in%20vivo%20on%20the%20aortic%20arch%20during%20a%20bolus%20injection%20of%200.1%20mmol%5C%2Fkg%20Gd-DTPA.%20An%20approximate%20geometrical%20model%20of%20the%20aortic%20arch%20constructed%20from%20the%20magnitude%20images%20was%20used%20to%20calculate%20the%20spatial%20variation%20of%20the%20field%20associated%20with%20the%20bolus.%20In%2014%20subjects%2C%20Gd%20concentration%20curves%20were%20measured%20dynamically%20%28one%20measurement%20per%20heart%20beat%29%20and%20indirectly%20validated%20by%20independent%202D%20cine%20phase%20contrast%20flow%20rate%20measurements.%20Flow%20rate%20measurements%20using%20indicator%20conservation%20with%20this%20novel%20quantitative%20susceptibility%20imaging%20technique%20were%20found%20to%20be%20in%20good%20agreement%20with%20those%20obtained%20from%20the%20cine%20phase%20contrast%20measurements%20in%20all%20subjects.%20Contrary%20to%20techniques%20that%20rely%20on%20intensity%2C%20the%20accuracy%20of%20this%20signal%20phase%20based%20method%20is%20insensitive%20to%20factors%20influencing%20signal%20intensity%20such%20as%20flip%20angle%2C%20coil%20sensitivity%2C%20relaxation%20changes%2C%20and%20time-of-flight%20effects%20extending%20the%20range%20of%20pulse%20sequences%20and%20contrast%20doses%20for%20which%20quantitative%20DCE-MRI%20can%20be%20applied.%22%2C%22date%22%3A%22Dec%202008%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1118%5C%2F1.3002309%22%2C%22ISSN%22%3A%220094-2405%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22DNKN89WD%22%2C%22XTA6KS7L%22%5D%2C%22dateModified%22%3A%222017-11-07T12%3A24%3A35Z%22%7D%7D%2C%7B%22key%22%3A%22LHPLXZV8%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Nguyen%20et%20al.%22%2C%22parsedDate%22%3A%222008-11%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BNguyen%2C%20T.D.%2C%20de%20Rochefort%2C%20L.%2C%20Spincemaille%2C%20P.%2C%20Cham%2C%20M.D.%2C%20Weinsaft%2C%20J.W.%2C%20Prince%2C%20M.R.%20and%20Wang%2C%20Y.%20%282008%29%20%26%23x201C%3BEffective%20motion-sensitizing%20magnetization%20preparation%20for%20black%20blood%20magnetic%20resonance%20imaging%20of%20the%20heart%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BJournal%20of%20magnetic%20resonance%20imaging%3A%20JMRI%26lt%3B%5C%2Fi%26gt%3B%2C%2028%285%29%2C%20pp.%201092%26%23x2013%3B1100.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjmri.21568%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjmri.21568%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Effective%20motion-sensitizing%20magnetization%20preparation%20for%20black%20blood%20magnetic%20resonance%20imaging%20of%20the%20heart%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thanh%20D.%22%2C%22lastName%22%3A%22Nguyen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ludovic%22%2C%22lastName%22%3A%22de%20Rochefort%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pascal%22%2C%22lastName%22%3A%22Spincemaille%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthew%20D.%22%2C%22lastName%22%3A%22Cham%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jonathan%20W.%22%2C%22lastName%22%3A%22Weinsaft%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Martin%20R.%22%2C%22lastName%22%3A%22Prince%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yi%22%2C%22lastName%22%3A%22Wang%22%7D%5D%2C%22abstractNote%22%3A%22PURPOSE%3A%20To%20investigate%20the%20effectiveness%20of%20flow%20signal%20suppression%20of%20a%20motion-sensitizing%20magnetization%20preparation%20%28MSPREP%29%20sequence%20and%20to%20optimize%20a%202D%20MSPREP%20steady-state%20free%20precession%20%28SSFP%29%20sequence%20for%20black%20blood%20imaging%20of%20the%20heart.%5CnMATERIALS%20AND%20METHODS%3A%20Using%20a%20flow%20phantom%2C%20the%20effect%20of%20varying%20field%20of%20speed%20%28FOS%29%2C%20b-value%2C%20voxel%20size%2C%20and%20flow%20pattern%20on%20the%20flow%20suppression%20was%20investigated.%20In%20seven%20healthy%20volunteers%2C%20black%20blood%20images%20of%20the%20heart%20were%20obtained%20at%201.5T%20with%20MSPREP-SSFP%20and%20double%20inversion%20recovery%20fast%20spin%20echo%20%28DIR-FSE%29%20techniques.%20Myocardium%20and%20blood%20signal-to-noise%20ratio%20%28SNR%29%20and%20myocardium-to-blood%20contrast-to-noise%20ratio%20%28CNR%29%20were%20measured.%20The%20optimal%20FOS%20that%20maximized%20the%20CNR%20for%20MSPREP-SSFP%20was%20determined.%5CnRESULTS%3A%20Phantom%20data%20demonstrated%20that%20the%20flow%20suppression%20was%20induced%20primarily%20by%20the%20velocity%20encoding%20effect.%20In%20humans%2C%20FOS%3D10-20%20cm%5C%2Fs%20was%20found%20to%20maximize%20the%20CNR%20for%20short-axis%20%28SA%29%20and%20four-chamber%20%284C%29%20views.%20Compared%20to%20DIR-FSE%2C%20MSPREP-SSFP%20provided%20similar%20blood%20SNR%20efficiency%20in%20the%20SA%20basal%20and%20mid-views%20and%20significantly%20lower%20blood%20SNR%20efficiency%20in%20the%20SA%20apical%20%28P%3D0.02%29%20and%204C%20%28P%3D0.01%29%20views%2C%20indicating%20similar%20or%20better%20blood%20suppression.%5CnCONCLUSION%3A%20Velocity%20encoding%20is%20the%20primary%20flow%20suppression%20mechanism%20of%20the%20MSPREP%20sequence%20and%202D%20MSPREP-SSFP%20black%20blood%20imaging%20of%20the%20heart%20is%20feasible%20in%20healthy%20subjects.%22%2C%22date%22%3A%22Nov%202008%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1002%5C%2Fjmri.21568%22%2C%22ISSN%22%3A%221053-1807%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22DNKN89WD%22%2C%22XTA6KS7L%22%5D%2C%22dateModified%22%3A%222017-11-07T12%3A25%3A07Z%22%7D%7D%5D%7D
Bouazizi, K., Yoganathan, T., Kober, F., Autret, G., Marsac, P., Delacroix, C., Soulez, S., Zarai, M., Nguyen, V., Squalli, A., Alayrac, P., Robidel, E., Tavitian, B., Redheuil, A., Hulot, J.-S. and Kachenoura, N. (2025) “Left ventricle strain and T1 mapping evaluation in a mouse model with myocardial infarction,” Scientific Reports, 15(1), p. 29579. Available at: https://doi.org/10.1038/s41598-025-09699-0.
Choquet, C., Sicard, P., Vahdat, J., Nguyen, T.H.M., Kober, F., Varlet, I., Bernard, M., Richard, S., Kelly, R.G., Lalevée, N. and Miquerol, L. (2023) “Nkx2-5 Loss of Function in the His-Purkinje System Hampers Its Maturation and Leads to Mechanical Dysfunction,” Journal of Cardiovascular Development and Disease, 10(5), p. 194. Available at: https://doi.org/10.3390/jcdd10050194.
Donghi, V., Tradi, F., Carbone, A., Viala, M., Gaubert, G., Nguyen, K., Reant, P., Donal, E., Eicher, J.-C., Selton-Suty, C., Huttin, O., Resseguier, N., Michel, N., Guazzi, M., Jacquier, A. and Habib, G. (2020) “Left-ventricular non-compaction-comparison between different techniques of quantification of trabeculations: Should the diagnostic thresholds be modified?,” Archives of Cardiovascular Diseases, 113(5), pp. 321–331. Available at: https://doi.org/10.1016/j.acvd.2020.01.004.
Tran, T.T., Mathieu, C., Torres, M., Loriod, B., Lê, L.T., Nguyen, C., Bernard, M., Leone, M. and Lalevée, N. (2019) “Effect of landiolol on sex-related transcriptomic changes in the myocardium during sepsis,” Intensive Care Medicine Experimental, 7(1), p. 50. Available at: https://doi.org/10.1186/s40635-019-0263-0.
Choquet, C., Nguyen, T.H.M., Sicard, P., Buttigieg, E., Tran, T.T., Kober, F., Varlet, I., Sturny, R., Costa, M.W., Harvey, R.P., Nguyen, C., Rihet, P., Richard, S., Bernard, M., Kelly, R.G., Lalevée, N. and Miquerol, L. (2018) “Deletion of Nkx2-5 in trabecular myocardium reveals the developmental origins of pathological heterogeneity associated with ventricular non-compaction cardiomyopathy,” PLoS genetics, 14(7), p. e1007502. Available at: https://doi.org/10.1371/journal.pgen.1007502.
Zhou, Z., Han, F., Rapacchi, S., Nguyen, K.-L., Brunengraber, D.Z., Kim, G.-H.J., Finn, J.P. and Hu, P. (2017) “Accelerated ferumoxytol-enhanced 4D multiphase, steady-state imaging with contrast enhancement (MUSIC) cardiovascular MRI: validation in pediatric congenital heart disease,” NMR in biomedicine, 30(1). Available at: https://doi.org/10.1002/nbm.3663.
Shao, J., Rapacchi, S., Nguyen, K.-L. and Hu, P. (2016) “Myocardial T1 mapping at 3.0 tesla using an inversion recovery spoiled gradient echo readout and bloch equation simulation with slice profile correction (BLESSPC) T1 estimation algorithm,” Journal of magnetic resonance imaging: JMRI, 43(2), pp. 414–425. Available at: https://doi.org/10.1002/jmri.24999.
Han, F., Zhou, Z., Rapacchi, S., Nguyen, K.-L., Finn, J.P. and Hu, P. (2015) “Segmented golden ratio radial reordering with variable temporal resolution for dynamic cardiac MRI,” Magnetic Resonance in Medicine [Preprint]. Available at: https://doi.org/10.1002/mrm.25861.
Cheung, P.P., Dougados, M., Andre, V., Balandraud, N., Chalès, G., Chary-Valckenaere, I., Dernis, E., Gill, G., Gilson, M., Guis, S., Mouterde, G., Pavy, S., Pouyol, F., Marhadour, T., Richette, P., Ruyssen-Witrand, A., Soubrier, M., Nguyen, M. and Gossec, L. (2014) “The learning curve of nurses for the assessment of swollen and tender joints in rheumatoid arthritis,” Joint, Bone, Spine: Revue Du Rhumatisme, 81(2), pp. 154–159. Available at: https://doi.org/10.1016/j.jbspin.2013.06.006.
de Rochefort, L., Nguyen, T., Brown, R., Spincemaille, P., Choi, G., Weinsaft, J., Prince, M.R. and Wang, Y. (2008) “In vivo quantification of contrast agent concentration using the induced magnetic field for time-resolved arterial input function measurement with MRI,” Medical Physics, 35(12), pp. 5328–5339. Available at: https://doi.org/10.1118/1.3002309.
Nguyen, T.D., de Rochefort, L., Spincemaille, P., Cham, M.D., Weinsaft, J.W., Prince, M.R. and Wang, Y. (2008) “Effective motion-sensitizing magnetization preparation for black blood magnetic resonance imaging of the heart,” Journal of magnetic resonance imaging: JMRI, 28(5), pp. 1092–1100. Available at: https://doi.org/10.1002/jmri.21568.