MATTEI Jean-Pierre
Medical Doctor (MD)
at AP-HMClinical researcher in the osteo articular field
Detailed Activities
Keywords
- Dynamic MRI/MRS
- Microstructure/architecture
- Sodium Homeostatis
- Ultra-high field MRI
Publications :
180164
MATTEI
1
harvard-cite-them-right-no-et-al
50
date
desc
year
2635
https://crmbm.univ-amu.fr/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A50%2C%22request_next%22%3A50%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%227FHVK5PB%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Guenoun%20et%20al.%22%2C%22parsedDate%22%3A%222023-08-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BGuenoun%2C%20D.%2C%20Wirth%2C%20T.%2C%20Roche%2C%20D.%2C%20Michel%2C%20C.P.%2C%20Daud%26%23xE9%3B%2C%20P.%2C%20Ogier%2C%20A.C.%2C%20Chagnaud%2C%20C.%2C%20Mattei%2C%20J.P.%2C%20Pini%2C%20L.%2C%20Guye%2C%20M.%2C%20Ollivier%2C%20M.%2C%20Bendahan%2C%20D.%20and%20Guis%2C%20S.%20%282023%29%20%26%23x201C%3BUltra-high%20field%20magnetic%20resonance%20imaging%20of%20the%20quadriceps%20tendon%20enthesis%20in%20healthy%20subjects%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BSurgical%20and%20Radiologic%20Anatomy%26lt%3B%5C%2Fi%26gt%3B%2C%2045%288%29%2C%20pp.%201049%26%23x2013%3B1054.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00276-023-03175-y%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00276-023-03175-y%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Ultra-high%20field%20magnetic%20resonance%20imaging%20of%20the%20quadriceps%20tendon%20enthesis%20in%20healthy%20subjects%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daphne%22%2C%22lastName%22%3A%22Guenoun%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Theo%22%2C%22lastName%22%3A%22Wirth%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Damien%22%2C%22lastName%22%3A%22Roche%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Constance%20P.%22%2C%22lastName%22%3A%22Michel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pierre%22%2C%22lastName%22%3A%22Daud%5Cu00e9%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Augustin%20C.%22%2C%22lastName%22%3A%22Ogier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christophe%22%2C%22lastName%22%3A%22Chagnaud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean%20Pierre%22%2C%22lastName%22%3A%22Mattei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lauriane%22%2C%22lastName%22%3A%22Pini%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maxime%22%2C%22lastName%22%3A%22Guye%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthieu%22%2C%22lastName%22%3A%22Ollivier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Bendahan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sandrine%22%2C%22lastName%22%3A%22Guis%22%7D%5D%2C%22abstractNote%22%3A%22Although%20enthesitis%20is%20a%20hallmark%20of%20several%20rheumatologic%20conditions%2C%20current%20imaging%20methods%20are%20still%20unable%20to%20characterize%20entheses%20changes%20because%20of%20the%20corresponding%20short%20transverse%20relaxation%20times%20%28T2%29.%20A%20growing%20number%20of%20MR%20studies%20have%20used%20Ultra-High%20Field%20%28UHF%29%20MRI%20in%20order%20to%20assess%20low-T2%20tissues%20e.g.%2C%20tendon%20but%20never%20in%20humans.%20The%20purpose%20of%20the%20present%20study%20was%20to%20assess%20in%20vivo%20the%20enthesis%20of%20the%20quadriceps%20tendon%20in%20healthy%20subjects%20using%20UHF%20MRI.%22%2C%22date%22%3A%222023-08-01%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1007%5C%2Fs00276-023-03175-y%22%2C%22ISSN%22%3A%221279-8517%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00276-023-03175-y%22%2C%22collections%22%3A%5B%22NW6SZQBR%22%2C%226BEMAGEW%22%2C%2248SZ2I24%22%2C%22ZP8JD3DQ%22%2C%22ACGLJ26R%22%2C%22XTA6KS7L%22%5D%2C%22dateModified%22%3A%222024-12-05T16%3A12%3A38Z%22%7D%7D%2C%7B%22key%22%3A%226B4PH48L%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Soldati%20et%20al.%22%2C%22parsedDate%22%3A%222021%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BSoldati%2C%20E.%2C%20Escoffier%2C%20L.%2C%20Gabriel%2C%20S.%2C%20Ogier%2C%20A.C.%2C%20Chagnaud%2C%20C.%2C%20Mattei%2C%20J.P.%2C%20Cammilleri%2C%20S.%2C%20Bendahan%2C%20D.%20and%20Guis%2C%20S.%20%282021%29%20%26%23x201C%3BAssessment%20of%20in%20vivo%20bone%20microarchitecture%20changes%20in%20an%20anti-TNF%26%23x3B1%3B%20treated%20psoriatic%20arthritic%20patient%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BPloS%20One%26lt%3B%5C%2Fi%26gt%3B%2C%2016%285%29%2C%20p.%20e0251788.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pone.0251788%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pone.0251788%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Assessment%20of%20in%20vivo%20bone%20microarchitecture%20changes%20in%20an%20anti-TNF%5Cu03b1%20treated%20psoriatic%20arthritic%20patient%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Enrico%22%2C%22lastName%22%3A%22Soldati%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lucas%22%2C%22lastName%22%3A%22Escoffier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sophie%22%2C%22lastName%22%3A%22Gabriel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Augustin%20C.%22%2C%22lastName%22%3A%22Ogier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christophe%22%2C%22lastName%22%3A%22Chagnaud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean%20P.%22%2C%22lastName%22%3A%22Mattei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Serge%22%2C%22lastName%22%3A%22Cammilleri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Bendahan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sandrine%22%2C%22lastName%22%3A%22Guis%22%7D%5D%2C%22abstractNote%22%3A%22OBJECTIVE%3A%20Psoriatic%20arthritis%20%28PsA%29%20is%20an%20inflammatory%20rheumatic%20disease%2C%20mediated%20in%20part%20by%20TNF%5Cu03b1%20and%20associated%20with%20bone%20loss.%20Anti-TNF%5Cu03b1%20treatment%20should%20inhibit%20this%20phenomenon%20and%20reduce%20the%20systemic%20bone%20loss.%20Ultra-high%20field%20MRI%20%28UHF%20MRI%29%20may%20be%20used%20to%20quantify%20bone%20microarchitecture%20%28BM%29%20in-vivo.%20In%20this%20study%2C%20we%20quantified%20BM%20using%20UHF%20MRI%20in%20a%20PsA%20patient%20and%20followed%20up%20the%20changes%20related%20to%20anti-TNF%5Cu03b1%20treatment.%5CnSUBJECTS%20AND%20METHODS%3A%20A%20non-treated%20PsA%20patient%20with%20knee%20arthritis%20and%207%20gender-matched%20controls%20were%20scanned%20using%20a%20gradient%20re-echo%20sequence%20at%20UHF%20MRI.%20After%20a%20year%20of%20Adalimumab%20treatment%2C%20the%20patient%20underwent%20a%20second%20UHF%20MRI.%20A%20PET-FNa%20imaging%20was%20performed%20before%20and%20after%20treatment%20to%20identify%20and%20localize%20the%20abnormal%20metabolic%20areas.%20BM%20was%20characterized%20using%20typical%20morphological%20parameters%20quantified%20in%2032%20regions%20of%20interest%20%28ROIs%29%20located%20in%20the%20patella%2C%20proximal%20tibia%2C%20and%20distal%20femur.%5CnRESULTS%3A%20Before%20treatment%2C%20the%20BM%20parameters%20were%20statistically%20different%20from%20controls%20in%2024%5C%2F32%20ROIs%20with%20differences%20reaching%20up%20to%2038%25.%20After%20treatment%2C%20BM%20parameters%20were%20normalized%20for%2015%20out%20of%2024%20ROIs.%20The%20hypermetabolic%20areas%20disclosed%20by%20PET-FNa%20before%20the%20treatment%20partly%20resumed%20after%20the%20treatment.%5CnCONCLUSION%3A%20Thanks%20to%20UHF%20MRI%2C%20we%20quantified%20in%20vivo%20BM%20anomalies%20in%20a%20PsA%20patient%20and%20we%20illustrated%20a%20major%20reversion%20after%20one%20year%20of%20treatment.%20Moreover%2C%20BM%20results%20highlighted%20that%20the%20abnormalities%20were%20not%20only%20localized%20in%20hypermetabolic%20regions%20identified%20by%20PET-FNa%2C%20suggesting%20that%20the%20bone%20loss%20was%20global%20and%20not%20related%20to%20inflammation.%22%2C%22date%22%3A%222021%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1371%5C%2Fjournal.pone.0251788%22%2C%22ISSN%22%3A%221932-6203%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22NW6SZQBR%22%5D%2C%22dateModified%22%3A%222024-10-29T10%3A45%3A30Z%22%7D%7D%2C%7B%22key%22%3A%225YWNKHEU%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22lastModifiedByUser%22%3A%7B%22id%22%3A1497928%2C%22username%22%3A%22fkober%22%2C%22name%22%3A%22Frank%20Kober%22%2C%22links%22%3A%7B%22alternate%22%3A%7B%22href%22%3A%22https%3A%5C%2F%5C%2Fwww.zotero.org%5C%2Ffkober%22%2C%22type%22%3A%22text%5C%2Fhtml%22%7D%7D%7D%2C%22creatorSummary%22%3A%22Poullain%20et%20al.%22%2C%22parsedDate%22%3A%222020-09%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BPoullain%2C%20F.%2C%20Mattei%2C%20J.C.%2C%20Rochwerger%2C%20A.%2C%20Bouvier%2C%20C.%2C%20Chagnaud%2C%20C.%2C%20Champsaur%2C%20P.%20and%20Le%20Corroller%2C%20T.%20%282020%29%20%26%23x201C%3BPercutaneous%20cryoablation%20of%20osteoblastoma%20in%20the%20proximal%20femur%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BSkeletal%20Radiology%26lt%3B%5C%2Fi%26gt%3B%2C%2049%289%29%2C%20pp.%201467%26%23x2013%3B1471.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00256-020-03413-z%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00256-020-03413-z%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Percutaneous%20cryoablation%20of%20osteoblastoma%20in%20the%20proximal%20femur%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22F.%22%2C%22lastName%22%3A%22Poullain%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%20C.%22%2C%22lastName%22%3A%22Mattei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Rochwerger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%22%2C%22lastName%22%3A%22Bouvier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%22%2C%22lastName%22%3A%22Chagnaud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P.%22%2C%22lastName%22%3A%22Champsaur%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22T.%22%2C%22lastName%22%3A%22Le%20Corroller%22%7D%5D%2C%22abstractNote%22%3A%22A%2037-year-old%20man%20presented%20with%20a%202-year%20history%20of%20left%20hip%20pain.%20Pretherapeutic%20imaging%20demonstrated%20a%204%5Cu00a0cm%20osteoblastoma%20located%20in%20the%20intertrochanteric%20region%20of%20the%20proximal%20femur%2C%20surrounded%20by%20extensive%20bone%20marrow%20edema.%20After%20multidisciplinary%20meeting%2C%20percutaneous%20cryoablation%20was%20decided%20and%20performed%20under%20computed%20tomography%20guidance%20using%20three%20cryoprobes%20to%20match%20the%20exact%20size%20and%20shape%20of%20the%20tumor%2C%20resulting%20in%20complete%20resolution%20of%20symptoms.%20Magnetic%20resonance%20imaging%20follow-up%20demonstrated%20resolution%20of%20the%20bone%20marrow%20edema%20pattern%20and%20ingrowth%20of%20fat%20at%20the%20periphery%20of%20the%20ablation%20zone%20consistent%20with%20long-term%20healing%20of%20the%20tumor.%22%2C%22date%22%3A%222020-09%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1007%5C%2Fs00256-020-03413-z%22%2C%22ISSN%22%3A%221432-2161%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22LPVXE8S8%22%5D%2C%22dateModified%22%3A%222025-07-07T13%3A27%3A18Z%22%7D%7D%2C%7B%22key%22%3A%222XFX7BDZ%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22lastModifiedByUser%22%3A%7B%22id%22%3A1497928%2C%22username%22%3A%22fkober%22%2C%22name%22%3A%22Frank%20Kober%22%2C%22links%22%3A%7B%22alternate%22%3A%7B%22href%22%3A%22https%3A%5C%2F%5C%2Fwww.zotero.org%5C%2Ffkober%22%2C%22type%22%3A%22text%5C%2Fhtml%22%7D%7D%7D%2C%22creatorSummary%22%3A%22Brui%20et%20al.%22%2C%22parsedDate%22%3A%222020-08%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BBrui%2C%20E.%2C%20Efimtcev%2C%20A.Y.%2C%20Fokin%2C%20V.A.%2C%20Fernandez%2C%20R.%2C%20Levchuk%2C%20A.G.%2C%20Ogier%2C%20A.C.%2C%20Samsonov%2C%20A.A.%2C%20Mattei%2C%20J.P.%2C%20Melchakova%2C%20I.V.%2C%20Bendahan%2C%20D.%20and%20Andreychenko%2C%20A.%20%282020%29%20%26%23x201C%3BDeep%20learning-based%20fully%20automatic%20segmentation%20of%20wrist%20cartilage%20in%20MR%20images%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BNMR%20in%20biomedicine%26lt%3B%5C%2Fi%26gt%3B%2C%2033%288%29%2C%20p.%20e4320.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fnbm.4320%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fnbm.4320%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Deep%20learning-based%20fully%20automatic%20segmentation%20of%20wrist%20cartilage%20in%20MR%20images%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ekaterina%22%2C%22lastName%22%3A%22Brui%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aleksandr%20Y.%22%2C%22lastName%22%3A%22Efimtcev%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vladimir%20A.%22%2C%22lastName%22%3A%22Fokin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Remi%22%2C%22lastName%22%3A%22Fernandez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anatoliy%20G.%22%2C%22lastName%22%3A%22Levchuk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Augustin%20C.%22%2C%22lastName%22%3A%22Ogier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexey%20A.%22%2C%22lastName%22%3A%22Samsonov%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean%20P.%22%2C%22lastName%22%3A%22Mattei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Irina%20V.%22%2C%22lastName%22%3A%22Melchakova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Bendahan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anna%22%2C%22lastName%22%3A%22Andreychenko%22%7D%5D%2C%22abstractNote%22%3A%22The%20study%20objective%20was%20to%20investigate%20the%20performance%20of%20a%20dedicated%20convolutional%20neural%20network%20%28CNN%29%20optimized%20for%20wrist%20cartilage%20segmentation%20from%202D%20MR%20images.%20CNN%20utilized%20a%20planar%20architecture%20and%20patch-based%20%28PB%29%20training%20approach%20that%20ensured%20optimal%20performance%20in%20the%20presence%20of%20a%20limited%20amount%20of%20training%20data.%20The%20CNN%20was%20trained%20and%20validated%20in%2020%20multi-slice%20MRI%20datasets%20acquired%20with%20two%20different%20coils%20in%2011%20subjects%20%28healthy%20volunteers%20and%20patients%29.%20The%20validation%20included%20a%20comparison%20with%20the%20alternative%20state-of-the-art%20CNN%20methods%20for%20the%20segmentation%20of%20joints%20from%20MR%20images%20and%20the%20ground-truth%20manual%20segmentation.%20When%20trained%20on%20the%20limited%20training%20data%2C%20the%20CNN%20outperformed%20significantly%20image-based%20and%20PB-U-Net%20networks.%20Our%20PB-CNN%20also%20demonstrated%20a%20good%20agreement%20with%20manual%20segmentation%20%28S%5Cu00f8rensen-Dice%20similarity%20coefficient%20%5BDSC%5D%20%3D%200.81%29%20in%20the%20representative%20%28central%20coronal%29%20slices%20with%20a%20large%20amount%20of%20cartilage%20tissue.%20Reduced%20performance%20of%20the%20network%20for%20slices%20with%20a%20very%20limited%20amount%20of%20cartilage%20tissue%20suggests%20the%20need%20for%20fully%203D%20convolutional%20networks%20to%20provide%20uniform%20performance%20across%20the%20joint.%20The%20study%20also%20assessed%20inter-%20and%20intra-observer%20variability%20of%20the%20manual%20wrist%20cartilage%20segmentation%20%28DSC%20%3D%200.78-0.88%20and%200.9%2C%20respectively%29.%20The%20proposed%20deep%20learning-based%20segmentation%20of%20the%20wrist%20cartilage%20from%20MRI%20could%20facilitate%20research%20of%20novel%20imaging%20markers%20of%20wrist%20osteoarthritis%20to%20characterize%20its%20progression%20and%20response%20to%20therapy.%22%2C%22date%22%3A%222020-08%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1002%5C%2Fnbm.4320%22%2C%22ISSN%22%3A%221099-1492%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22NW6SZQBR%22%5D%2C%22dateModified%22%3A%222025-03-19T13%3A33%3A19Z%22%7D%7D%2C%7B%22key%22%3A%22RAQXVXL7%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Guenoun%20et%20al.%22%2C%22parsedDate%22%3A%222020-01-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BGuenoun%2C%20D.%2C%20Pithioux%2C%20M.%2C%20Souplet%2C%20J.-C.%2C%20Guis%2C%20S.%2C%20Le%20Corroller%2C%20T.%2C%20Four%26%23xE9%3B%2C%20A.%2C%20Pauly%2C%20V.%2C%20Mattei%2C%20J.-P.%2C%20Bernard%2C%20M.%2C%20Guye%2C%20M.%2C%20Chabrand%2C%20P.%2C%20Champsaur%2C%20P.%20and%20Bendahan%2C%20D.%20%282020%29%20%26%23x201C%3BAssessment%20of%20proximal%20femur%20microarchitecture%20using%20ultra-high%20field%20MRI%20at%207%20Tesla%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BDiagnostic%20and%20Interventional%20Imaging%26lt%3B%5C%2Fi%26gt%3B%2C%20101%281%29%2C%20pp.%2045%26%23x2013%3B53.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.diii.2019.06.013%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.diii.2019.06.013%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Assessment%20of%20proximal%20femur%20microarchitecture%20using%20ultra-high%20field%20MRI%20at%207%20Tesla%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D.%22%2C%22lastName%22%3A%22Guenoun%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Pithioux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%20-C.%22%2C%22lastName%22%3A%22Souplet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Guis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22T.%22%2C%22lastName%22%3A%22Le%20Corroller%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Four%5Cu00e9%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22V.%22%2C%22lastName%22%3A%22Pauly%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%20-P.%22%2C%22lastName%22%3A%22Mattei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Bernard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Guye%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P.%22%2C%22lastName%22%3A%22Chabrand%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P.%22%2C%22lastName%22%3A%22Champsaur%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D.%22%2C%22lastName%22%3A%22Bendahan%22%7D%5D%2C%22abstractNote%22%3A%22Purpose%5CnThe%20purpose%20of%20this%20study%20was%20to%20investigate%20bone%20microarchitecture%20of%20cadaveric%20proximal%20femurs%20using%20ultra-high%20field%20%28UHF%29%207-Tesla%20magnetic%20resonance%20imaging%20%28MRI%29%20and%20to%20compare%20the%20corresponding%20metrics%20with%20failure%20load%20assessed%20during%20mechanical%20compression%20test%20and%20areal%20bone%20mineral%20density%20%28ABMD%29%20measured%20using%20dual-energy%20X-ray%20absorptiometry.%5CnMaterials%20and%20methods%5CnABMD%20of%20ten%20proximal%20femurs%20from%20five%20cadavers%20%285%20women%3B%20mean%20age%3D86.2%5Cu00b13.8%20%28SD%29%20years%3B%20range%3A%2082.5%5Cu201390%20years%29%20were%20investigated%20using%20dual-energy%20X-ray%20absorptiometry%20and%20the%20bone%20volume%20fraction%2C%20trabecular%20thickness%2C%20trabecular%20spacing%2C%20fractal%20dimension%2C%20Euler%20characteristics%2C%20connectivity%20density%20and%20degree%20of%20anisotropy%20of%20each%20femur%20was%20quantified%20using%20UHF%20MRI.%20The%20whole%20set%20of%20specimens%20underwent%20mechanical%20compression%20tests%20to%20failure.%20The%20inter-rater%20reliability%20of%20microarchitecture%20characterization%20was%20assessed%20with%20the%20intraclass%20correlation%20coefficient%20%28ICC%29.%20Associations%20were%20searched%20using%20correlation%20tests%20and%20multiple%20regression%20analysis.%5CnResults%5CnThe%20inter-rater%20reliability%20for%20bone%20microarchitecture%20parameters%20measurement%20was%20good%20with%20ICC%20ranging%20from%200.80%20and%200.91.%20ABMD%20and%20the%20whole%20set%20of%20microarchitecture%20metrics%20but%20connectivity%20density%20significantly%20correlated%20with%20failure%20load.%20Microarchitecture%20metrics%20correlated%20to%20each%20other%20but%20did%20not%20correlate%20with%20ABMD.%20Multiple%20regression%20analysis%20disclosed%20that%20the%20combination%20of%20microarchitecture%20metrics%20and%20ABMD%20improved%20the%20association%20with%20failure%20load.%5CnConclusion%5CnFemur%20bone%20microarchitecture%20metrics%20quantified%20using%20UHF%20MRI%20significantly%20correlated%20with%20biomechanical%20parameters.%20The%20multimodal%20assessment%20of%20ABMD%20and%20trabecular%20bone%20microarchitecture%20using%20UHF%20MRI%20provides%20more%20information%20about%20fracture%20risk%20of%20femoral%20bone%20and%20might%20be%20of%20interest%20for%20future%20investigations%20of%20patients%20with%20undetected%20osteoporosis.%22%2C%22date%22%3A%22January%201%2C%202020%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.diii.2019.06.013%22%2C%22ISSN%22%3A%222211-5684%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fwww.sciencedirect.com%5C%2Fscience%5C%2Farticle%5C%2Fpii%5C%2FS2211568419301676%22%2C%22collections%22%3A%5B%225Z6CVJGB%22%2C%22NW6SZQBR%22%2C%226M38MJ3E%22%2C%226BEMAGEW%22%2C%22XTA6KS7L%22%5D%2C%22dateModified%22%3A%222025-07-07T13%3A27%3A18Z%22%7D%7D%2C%7B%22key%22%3A%227Z8AKXLC%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Cammilleri%20et%20al.%22%2C%22parsedDate%22%3A%222019-05%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BCammilleri%2C%20S.%2C%20Gabriel%2C%20S.%2C%20Le%20Troter%2C%20A.%2C%20Chagnaud%2C%20C.%2C%20Mattei%2C%20J.P.%2C%20Bendahan%2C%20D.%20and%20Guis%2C%20S.%20%282019%29%20%26%23x201C%3BKnee%20psoriatic%20enthesitis%20assessed%20using%20positron%20emission%20tomography%20%28PET%29%20-%20FNa%20merged%20to%20ultrahigh%20field%20magnetic%20resonance%20imaging%20%28UHF-MRI%29%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BJoint%20Bone%20Spine%26lt%3B%5C%2Fi%26gt%3B%2C%2086%283%29%2C%20pp.%20387%26%23x2013%3B388.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jbspin.2019.01.002%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jbspin.2019.01.002%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Knee%20psoriatic%20enthesitis%20assessed%20using%20positron%20emission%20tomography%20%28PET%29%20-%20FNa%20merged%20to%20ultrahigh%20field%20magnetic%20resonance%20imaging%20%28UHF-MRI%29%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Serge%22%2C%22lastName%22%3A%22Cammilleri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sophie%22%2C%22lastName%22%3A%22Gabriel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Arnaud%22%2C%22lastName%22%3A%22Le%20Troter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christophe%22%2C%22lastName%22%3A%22Chagnaud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean%20Pierre%22%2C%22lastName%22%3A%22Mattei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Bendahan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sandrine%22%2C%22lastName%22%3A%22Guis%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%22MAY%202019%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.jbspin.2019.01.002%22%2C%22ISSN%22%3A%221297-319X%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22NW6SZQBR%22%2C%226BEMAGEW%22%2C%225P5FWCR9%22%5D%2C%22dateModified%22%3A%222024-10-29T10%3A45%3A30Z%22%7D%7D%2C%7B%22key%22%3A%228PPJ22N7%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Four%5Cu00e9%20et%20al.%22%2C%22parsedDate%22%3A%222019-03%22%2C%22numChildren%22%3A4%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BFour%26%23xE9%3B%2C%20A.%2C%20Pini%2C%20L.%2C%20Rappacchi%2C%20S.%2C%20Ogier%2C%20A.C.%2C%20Mattei%2C%20J.-C.%2C%20Bydder%2C%20M.%2C%20Guye%2C%20M.%20and%20Bendahan%2C%20D.%20%282019%29%20%26%23x201C%3BUltrahigh-Field%20Multimodal%20MRI%20Assessment%20of%20Muscle%20Damage%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BJournal%20of%20magnetic%20resonance%20imaging%3A%20JMRI%26lt%3B%5C%2Fi%26gt%3B%2C%2049%283%29%2C%20pp.%20904%26%23x2013%3B906.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjmri.26222%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjmri.26222%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Ultrahigh-Field%20Multimodal%20MRI%20Assessment%20of%20Muscle%20Damage%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandre%22%2C%22lastName%22%3A%22Four%5Cu00e9%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lauriane%22%2C%22lastName%22%3A%22Pini%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stanislas%22%2C%22lastName%22%3A%22Rappacchi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Augustin%20C.%22%2C%22lastName%22%3A%22Ogier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Camille%22%2C%22lastName%22%3A%22Mattei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mark%22%2C%22lastName%22%3A%22Bydder%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maxime%22%2C%22lastName%22%3A%22Guye%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Bendahan%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%22Mar%202019%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1002%5C%2Fjmri.26222%22%2C%22ISSN%22%3A%221522-2586%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22NW6SZQBR%22%2C%226M38MJ3E%22%2C%22SK6VWU7K%22%2C%2248SZ2I24%22%2C%22XTA6KS7L%22%5D%2C%22dateModified%22%3A%222024-09-16T13%3A08%3A27Z%22%7D%7D%2C%7B%22key%22%3A%22MRA3KXDP%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22lastModifiedByUser%22%3A%7B%22id%22%3A1497928%2C%22username%22%3A%22fkober%22%2C%22name%22%3A%22Frank%20Kober%22%2C%22links%22%3A%7B%22alternate%22%3A%7B%22href%22%3A%22https%3A%5C%2F%5C%2Fwww.zotero.org%5C%2Ffkober%22%2C%22type%22%3A%22text%5C%2Fhtml%22%7D%7D%7D%2C%22creatorSummary%22%3A%22Louis%20et%20al.%22%2C%22parsedDate%22%3A%222018-05%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BLouis%2C%20M.L.%2C%20Magalon%2C%20J.%2C%20Jouve%2C%20E.%2C%20Bornet%2C%20C.E.%2C%20Mattei%2C%20J.C.%2C%20Chagnaud%2C%20C.%2C%20Rochwerger%2C%20A.%2C%20Veran%2C%20J.%20and%20Sabatier%2C%20F.%20%282018%29%20%26%23x201C%3BGrowth%20Factors%20Levels%20Determine%20Efficacy%20of%20Platelets%20Rich%20Plasma%20Injection%20in%20Knee%20Osteoarthritis%3A%20A%20Randomized%20Double%20Blind%20Noninferiority%20Trial%20Compared%20With%20Viscosupplementation%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BArthroscopy%3A%20The%20Journal%20of%20Arthroscopic%20%26amp%3B%20Related%20Surgery%3A%20Official%20Publication%20of%20the%20Arthroscopy%20Association%20of%20North%20America%20and%20the%20International%20Arthroscopy%20Association%26lt%3B%5C%2Fi%26gt%3B%2C%2034%285%29%2C%20pp.%201530-1540.e2.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.arthro.2017.11.035%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.arthro.2017.11.035%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Growth%20Factors%20Levels%20Determine%20Efficacy%20of%20Platelets%20Rich%20Plasma%20Injection%20in%20Knee%20Osteoarthritis%3A%20A%20Randomized%20Double%20Blind%20Noninferiority%20Trial%20Compared%20With%20Viscosupplementation%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marie%20Laure%22%2C%22lastName%22%3A%22Louis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jeremy%22%2C%22lastName%22%3A%22Magalon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elizabeth%22%2C%22lastName%22%3A%22Jouve%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Charles%20Eric%22%2C%22lastName%22%3A%22Bornet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean%20Camille%22%2C%22lastName%22%3A%22Mattei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christophe%22%2C%22lastName%22%3A%22Chagnaud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandre%22%2C%22lastName%22%3A%22Rochwerger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julie%22%2C%22lastName%22%3A%22Veran%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florence%22%2C%22lastName%22%3A%22Sabatier%22%7D%5D%2C%22abstractNote%22%3A%22PURPOSE%3A%20To%20assess%20the%20noninferiority%20of%20a%20single%20platelet-rich%20plasma%20%28PRP%29%20injection%20compared%20with%20hyaluronic%20acid%20%28HA%29%2C%20to%20alleviate%20pain%20and%20enhance%20functional%20capacity%20in%20knee%20osteoarthritis%2C%20and%20identify%20biological%20characteristics%20of%20PRP%20that%20may%20affect%20their%20efficacy.%5CnMETHODS%3A%20Fifty-four%20patients%20with%20symptomatic%20knee%20osteoarthritis%20received%20a%20single%20injection%20of%20either%20PRP%20%2826%20patients%29%20or%20HA%20%2828%20patients%29.%20They%20were%20assessed%20at%20baseline%20and%20at%201%2C%203%2C%20and%206%5Cu00a0months.%20The%20primary%20endpoint%20was%20the%20change%20in%20Western%20Ontario%20and%20McMaster%20Universities%20Arthritis%20Index%20%28WOMAC%29%20score%20at%203%5Cu00a0months%2C%20and%20secondary%20endpoints%20were%20responders%26%23039%3B%20rate%20%28improvement%20of%20at%20least%205%20points%20or%2040%25%20of%20WOMAC%20total%20score%20at%203%5Cu00a0months%29%20of%20pain%20evaluation%20and%20patient%26%23039%3Bs%20subjective%20satisfaction.%20Cell%20counts%20and%20the%20contents%20of%20vascular%20endothelial%20growth%20factor%20%28VEGF%29%2C%20platelet-derived%20growth%20factor-AB%20%28PDGF-AB%29%2C%20transforming%20growth%20factor%20beta%201%20%28TGF-%5Cu03b21%29%20content%20of%20injected%20PRP%20were%20assessed%20to%20analyze%20their%20relationship%20with%20clinical%20outcome.%5CnRESULTS%3A%20Both%20treatments%20proved%20their%20improvement%20in%20knee%20functional%20status%20and%20symptom%20relief%2C%20with%20a%20significant%20decrease%20observed%20at%201%5Cu00a0month%20on%20all%20scores%20except%20for%20pain%20VAS%20in%20PRP%20group%20and%20WOMAC%20function%20score%20in%20the%20HA%20group.%20No%20difference%20between%20groups%20regarding%20WOMAC%20and%20VAS%20scores%20was%20observed.%20A%20higher%20percentage%20of%20responders%20was%20observed%20in%20the%20PRP%20group%20%2872.7%25%29%20than%20in%20the%20HA%20group%20%2845.8%25%29%20without%20significance%20%28P%5Cu00a0%3D%20.064%29.%20The%20quantity%20of%20injected%20PDGF-AB%20and%20TGF-%5Cu03b21%20correlated%20with%20the%20change%20in%20WOMAC%20scores%20at%203%5Cu00a0months%20and%20was%20lower%20in%20responders%20than%20in%20nonresponders%20%28P%5Cu00a0%3D%20.009%20and%20P%5Cu00a0%3D%20.003%2C%20respectively%29.%5CnCONCLUSIONS%3A%20Current%20results%20indicated%20that%20a%20single%20injection%20of%20very%20pure%20PRP%20offers%20a%20significant%20clinical%20improvement%20in%20the%20management%20of%20knee%20osteoarthritis%2C%20equivalent%20to%20a%20single%20HA%20injection%20in%20this%20patient%20population.%20Moreover%2C%20a%20significant%20correlation%20between%20the%20doses%20of%20TGF-%5Cu03b21%20and%20PDGF-AB%20and%20the%20worsening%20of%20WOMAC%20score%203%5Cu00a0months%20after%20the%20procedure%20was%20found.%5CnLEVEL%20OF%20EVIDENCE%3A%20Level%20II%2C%20randomized%20double%20blind%20controlled%20trial.%22%2C%22date%22%3A%222018-05%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.arthro.2017.11.035%22%2C%22ISSN%22%3A%221526-3231%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22LPVXE8S8%22%5D%2C%22dateModified%22%3A%222023-07-10T16%3A08%3A08Z%22%7D%7D%2C%7B%22key%22%3A%22IC2CRB45%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Guenoun%20et%20al.%22%2C%22parsedDate%22%3A%222017-10-15%22%2C%22numChildren%22%3A3%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BGuenoun%2C%20D.%2C%20Four%26%23xE9%3B%2C%20A.%2C%20Pithioux%2C%20M.%2C%20Guis%2C%20S.%2C%20Le%20Corroller%2C%20T.%2C%20Mattei%2C%20J.-P.%2C%20Pauly%2C%20V.%2C%20Guye%2C%20M.%2C%20Bernard%2C%20M.%2C%20Chabrand%2C%20P.%2C%20Champsaur%2C%20P.%20and%20Bendahan%2C%20D.%20%282017%29%20%26%23x201C%3BCorrelative%20Analysis%20of%20Vertebral%20Trabecular%20Bone%20Microarchitecture%20and%20Mechanical%20Properties%3A%20A%20Combined%20Ultra-high%20Field%20%287%20Tesla%29%20MRI%20and%20Biomechanical%20Investigation%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BSpine%26lt%3B%5C%2Fi%26gt%3B%2C%2042%2820%29%2C%20pp.%20E1165%26%23x2013%3BE1172.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FBRS.0000000000002163%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FBRS.0000000000002163%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Correlative%20Analysis%20of%20Vertebral%20Trabecular%20Bone%20Microarchitecture%20and%20Mechanical%20Properties%3A%20A%20Combined%20Ultra-high%20Field%20%287%20Tesla%29%20MRI%20and%20Biomechanical%20Investigation%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daphne%22%2C%22lastName%22%3A%22Guenoun%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandre%22%2C%22lastName%22%3A%22Four%5Cu00e9%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Martine%22%2C%22lastName%22%3A%22Pithioux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sandrine%22%2C%22lastName%22%3A%22Guis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Le%20Corroller%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Pierre%22%2C%22lastName%22%3A%22Mattei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vanessa%22%2C%22lastName%22%3A%22Pauly%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maxime%22%2C%22lastName%22%3A%22Guye%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Monique%22%2C%22lastName%22%3A%22Bernard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Patrick%22%2C%22lastName%22%3A%22Chabrand%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pierre%22%2C%22lastName%22%3A%22Champsaur%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Bendahan%22%7D%5D%2C%22abstractNote%22%3A%22STUDY%20DESIGN%3A%20High-resolution%20imaging%20and%20biomechanical%20investigation%20of%20ex-vivo%20vertebrae.%5CnOBJECTIVE%3A%20The%20aim%20of%20this%20study%20was%20to%20assess%20bone%20microarchitecture%20of%20cadaveric%20vertebrae%20using%20ultra-high%20field%20%28UHF%29%207%20Tesla%20magnetic%20resonance%20imaging%20%28MRI%29%20and%20to%20determine%20whether%20the%20corresponding%20microarchitecture%20parameters%20were%20related%20to%20bone%20mineral%20density%20%28BMD%29%20and%20bone%20strength%20assessed%20by%20dual-energy%20x-ray%20absorptiometry%20%28DXA%29%20and%20mechanical%20compression%20tests.%5CnSUMMARY%20OF%20BACKGROUND%20DATA%3A%20Limitations%20of%20DXA%20for%20the%20assessment%20of%20bone%20fragility%20and%20osteoporosis%20have%20been%20recognized%20and%20criteria%20of%20microarchitecture%20alteration%20have%20been%20included%20in%20the%20definition%20of%20osteoporosis.%20Although%20vertebral%20fracture%20is%20the%20most%20common%20osteoporotic%20fracture%2C%20no%20study%20has%20assessed%20directly%20vertebral%20trabecular%20bone%20microarchitecture.%5CnMETHODS%3A%20BMD%20of%2024%20vertebrae%20%28L2%2C%20L3%2C%20L4%29%20from%20eight%20cadavers%20was%20investigated%20using%20DXA.%20The%20bone%20volume%20fraction%20%28BVF%29%2C%20trabecular%20thickness%20%28Tb.Th%29%2C%20and%20trabecular%20spacing%20%28Tb.Sp%29%20of%20each%20vertebra%20were%20quantified%20using%20UHF%20MRI.%20Measurements%20were%20performed%20by%20two%20operators%20to%20characterize%20the%20inter-rater%20reliability.%20The%20whole%20set%20of%20specimens%20underwent%20mechanical%20compression%20tests%20to%20failure%20and%20the%20corresponding%20failure%20stress%20was%20calculated.%5CnRESULTS%3A%20The%20inter-rater%20reliability%20for%20bone%20microarchitecture%20parameters%20was%20good%20with%20intraclass%20correlation%20coefficients%20ranging%20from%200.82%20to%200.94.%20Failure%20load%20and%20stress%20were%20significantly%20correlated%20with%20BVF%2C%20Tb.Sp%2C%20and%20BMD%20%28P%5Cu200a%26lt%3B%5Cu200a0.05%29.%20Tb.Th%20was%20only%20correlated%20with%20the%20failure%20stress%20%28P%5Cu200a%26lt%3B%5Cu200a0.05%29.%20Multiple%20regression%20analysis%20demonstrated%20that%20the%20combination%20of%20BVF%20and%20BMD%20improved%20the%20prediction%20of%20the%20failure%20stress%20from%20an%20adjusted%20R%5Cu200a%3D%5Cu200a0.384%20for%20BMD%20alone%20to%20an%20adjusted%20R%5Cu200a%3D%5Cu200a0.414.%5CnCONCLUSION%3A%20We%20demonstrated%20for%20the%20first%20time%20that%20the%20vertebral%20bone%20microarchitecture%20assessed%20with%20UHF%20MRI%20was%20significantly%20correlated%20with%20biomechanical%20parameters.%20Our%20data%20suggest%20that%20the%20multimodal%20assessment%20of%20BMD%20and%20trabecular%20bone%20microarchitecture%20with%20UHF%20MRI%20provides%20additional%20information%20on%20the%20risk%20of%20vertebral%20bone%20fracture%20and%20might%20be%20of%20interest%20for%20the%20future%20investigation%20of%20selected%20osteoporotic%20patients.%5CnLEVEL%20OF%20EVIDENCE%3A%20N%20%5C%2FA.%22%2C%22date%22%3A%22Oct%2015%2C%202017%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1097%5C%2FBRS.0000000000002163%22%2C%22ISSN%22%3A%221528-1159%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%225Z6CVJGB%22%2C%22NW6SZQBR%22%2C%226M38MJ3E%22%2C%226BEMAGEW%22%2C%22XTA6KS7L%22%5D%2C%22dateModified%22%3A%222025-07-07T13%3A27%3A17Z%22%7D%7D%2C%7B%22key%22%3A%22XTRJMJ3S%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22lastModifiedByUser%22%3A%7B%22id%22%3A1497928%2C%22username%22%3A%22fkober%22%2C%22name%22%3A%22Frank%20Kober%22%2C%22links%22%3A%7B%22alternate%22%3A%7B%22href%22%3A%22https%3A%5C%2F%5C%2Fwww.zotero.org%5C%2Ffkober%22%2C%22type%22%3A%22text%5C%2Fhtml%22%7D%7D%7D%2C%22creatorSummary%22%3A%22Wegrzyk%20et%20al.%22%2C%22parsedDate%22%3A%222017-06-02%22%2C%22numChildren%22%3A3%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BWegrzyk%2C%20J.%2C%20Ranjeva%2C%20J.-P.%2C%20Four%26%23xE9%3B%2C%20A.%2C%20Kavounoudias%2C%20A.%2C%20Vilmen%2C%20C.%2C%20Mattei%2C%20J.-P.%2C%20Guye%2C%20M.%2C%20Maffiuletti%2C%20N.A.%2C%20Place%2C%20N.%2C%20Bendahan%2C%20D.%20and%20Gondin%2C%20J.%20%282017%29%20%26%23x201C%3BSpecific%20brain%20activation%20patterns%20associated%20with%20two%20neuromuscular%20electrical%20stimulation%20protocols%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BScientific%20Reports%26lt%3B%5C%2Fi%26gt%3B%2C%207%281%29%2C%20p.%202742.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-017-03188-9%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-017-03188-9%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Specific%20brain%20activation%20patterns%20associated%20with%20two%20neuromuscular%20electrical%20stimulation%20protocols%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jennifer%22%2C%22lastName%22%3A%22Wegrzyk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Philippe%22%2C%22lastName%22%3A%22Ranjeva%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandre%22%2C%22lastName%22%3A%22Four%5Cu00e9%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne%22%2C%22lastName%22%3A%22Kavounoudias%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christophe%22%2C%22lastName%22%3A%22Vilmen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Pierre%22%2C%22lastName%22%3A%22Mattei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maxime%22%2C%22lastName%22%3A%22Guye%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicola%20A.%22%2C%22lastName%22%3A%22Maffiuletti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Place%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Bendahan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julien%22%2C%22lastName%22%3A%22Gondin%22%7D%5D%2C%22abstractNote%22%3A%22The%20influence%20of%20neuromuscular%20electrical%20stimulation%20%28NMES%29%20parameters%20on%20brain%20activation%20has%20been%20scarcely%20investigated.%20We%20aimed%20at%20comparing%20two%20frequently%20used%20NMES%20protocols%20-%20designed%20to%20vary%20in%20the%20extent%20of%20sensory%20input.%20Whole-brain%20functional%20magnetic%20resonance%20imaging%20was%20performed%20in%20sixteen%20healthy%20subjects%20during%20wide-pulse%20high-frequency%20%28WPHF%2C%20100%5Cu2009Hz-1%5Cu2009ms%29%20and%20conventional%20%28CONV%2C%2025%5Cu2009Hz-0.05%5Cu2009ms%29%20NMES%20applied%20over%20the%20triceps%20surae.%20Each%20protocol%20included%2020%20isometric%20contractions%20performed%20at%2010%25%20of%20maximal%20force.%20Voluntary%20plantar%20flexions%20%28VOL%29%20were%20performed%20as%20control%20trial.%20Mean%20force%20was%20not%20different%20among%20the%20three%20protocols%2C%20however%2C%20total%20current%20charge%20was%20higher%20for%20WPHF%20than%20for%20CONV.%20All%20protocols%20elicited%20significant%20activations%20of%20the%20sensorimotor%20network%2C%20cerebellum%20and%20thalamus.%20WPHF%20resulted%20in%20lower%20deactivation%20in%20the%20secondary%20somatosensory%20cortex%20and%20precuneus.%20Bilateral%20thalami%20and%20caudate%20nuclei%20were%20hyperactivated%20for%20CONV.%20The%20modulation%20of%20the%20NMES%20parameters%20resulted%20in%20differently%20activated%5C%2Fdeactivated%20regions%20related%20to%20total%20current%20charge%20of%20the%20stimulation%20but%20not%20to%20mean%20force.%20By%20targeting%20different%20cerebral%20brain%20regions%2C%20the%20two%20NMES%20protocols%20might%20allow%20for%20individually-designed%20rehabilitation%20training%20in%20patients%20who%20can%20no%20longer%20execute%20voluntary%20movements.%22%2C%22date%22%3A%22Jun%2002%2C%202017%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41598-017-03188-9%22%2C%22ISSN%22%3A%222045-2322%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%226XQENTHJ%22%2C%227FK4UDH9%22%2C%22NW6SZQBR%22%2C%22UP3H3ICX%22%2C%226M38MJ3E%22%2C%22SXWA9VN6%22%2C%22XTA6KS7L%22%5D%2C%22dateModified%22%3A%222024-12-13T09%3A12%3A43Z%22%7D%7D%2C%7B%22key%22%3A%22SIVS2A5W%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Martin%20et%20al.%22%2C%22parsedDate%22%3A%222016-08%22%2C%22numChildren%22%3A3%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BMartin%2C%20A.%2C%20Grospr%26%23xEA%3Btre%2C%20S.%2C%20Vilmen%2C%20C.%2C%20Guye%2C%20M.%2C%20Mattei%2C%20J.-P.%2C%20LE%20Fur%2C%20Y.%2C%20Bendahan%2C%20D.%20and%20Gondin%2C%20J.%20%282016%29%20%26%23x201C%3BThe%20Etiology%20of%20Muscle%20Fatigue%20Differs%20between%20Two%20Electrical%20Stimulation%20Protocols%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BMedicine%20and%20Science%20in%20Sports%20and%20Exercise%26lt%3B%5C%2Fi%26gt%3B%2C%2048%288%29%2C%20pp.%201474%26%23x2013%3B1484.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1249%5C%2FMSS.0000000000000930%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1249%5C%2FMSS.0000000000000930%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22The%20Etiology%20of%20Muscle%20Fatigue%20Differs%20between%20Two%20Electrical%20Stimulation%20Protocols%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alain%22%2C%22lastName%22%3A%22Martin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sidney%22%2C%22lastName%22%3A%22Grospr%5Cu00eatre%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christophe%22%2C%22lastName%22%3A%22Vilmen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maxime%22%2C%22lastName%22%3A%22Guye%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Pierre%22%2C%22lastName%22%3A%22Mattei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yann%22%2C%22lastName%22%3A%22LE%20Fur%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Bendahan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julien%22%2C%22lastName%22%3A%22Gondin%22%7D%5D%2C%22abstractNote%22%3A%22PURPOSE%3A%20This%20study%20aimed%20at%20investigating%20the%20mechanisms%20involved%20in%20the%20force%20reduction%20induced%20by%20two%20electrical%20stimulation%20%28ES%29%20protocols%20that%20were%20designed%20to%20activate%20motor%20units%20differently.%5CnMETHODS%3A%20The%20triceps%20surae%20of%2011%20healthy%20subjects%20%288%20men%3B%20age%2C%20~28%20yr%29%20was%20activated%20using%20ES%20applied%20over%20the%20tibial%20nerve.%20Two%20ES%20protocols%20%28conventional%20%5BCONV%5D%3A%2020%20Hz%2C%200.05%20ms%20vs%20wide-pulse%20high-frequency%20%5BWPHF%5D%3A%2080%20Hz%2C%201%20ms%29%20were%20performed%20and%20involved%2040%20trains%20%286%20s%20on-6%20s%20off%29%20delivered%20at%20an%20intensity%20%28IES%29%20evoking%2020%25%20of%20maximal%20voluntary%20contraction.%20To%20analyze%20the%20mechanical%20properties%20of%20the%20motor%20units%20activated%20at%20IES%2C%20force-frequency%20relation%20was%20evoked%20before%20and%20after%20each%20protocol.%20H-reflex%20and%20M-wave%20responses%20evoked%20by%20the%20last%20stimulation%20pulse%20were%20also%20assessed%20during%20each%20ES%20protocol.%20Electromyographic%20responses%20%28%5Cu2211EMG%29%20were%20recorded%20after%20each%20train%20to%20analyze%20the%20behavior%20of%20the%20motor%20units%20activated%20at%20IES.%20Metabolic%20variables%2C%20including%20relative%20concentrations%20of%20phosphocreatine%20and%20inorganic%20phosphate%20as%20well%20as%20intracellular%20pH%2C%20were%20assessed%20using%20P-MR%20spectroscopy%20during%20each%20protocol.%5CnRESULTS%3A%20Larger%20H-reflex%20amplitudes%20were%20observed%20during%20WPHF%20as%20compared%20with%20CONV%2C%20whereas%20opposite%20findings%20were%20observed%20for%20M-wave%20amplitudes.%20Despite%20this%20difference%2C%20both%20the%20force%20reduction%20%28-26%25%29%20and%20metabolic%20changes%20were%20similar%20between%20the%20two%20protocols.%20The%20CONV%20protocol%20induced%20a%20rightward%20shift%20of%20the%20force-frequency%20relation%2C%20whereas%20a%20significant%20reduction%20of%20the%20%5Cu2211EMG%20evoked%20at%20IES%20was%20observed%20only%20for%20the%20WPHF.%5CnCONCLUSIONS%3A%20These%20results%20suggest%20that%20a%20decreased%20number%20of%20active%20motor%20units%20mainly%20contributed%20to%20WPHF-induced%20force%20decrease%2C%20whereas%20intracellular%20processes%20were%20most%20likely%20involved%20in%20the%20force%20reduction%20occurring%20during%20CONV%20stimulation.%22%2C%22date%22%3A%22Aug%202016%22%2C%22language%22%3A%22ENG%22%2C%22DOI%22%3A%2210.1249%5C%2FMSS.0000000000000930%22%2C%22ISSN%22%3A%221530-0315%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22SVI8UJ6H%22%2C%226XQENTHJ%22%2C%227FK4UDH9%22%2C%22NW6SZQBR%22%2C%22XTA6KS7L%22%5D%2C%22dateModified%22%3A%222023-12-15T10%3A50%3A08Z%22%7D%7D%2C%7B%22key%22%3A%22YX9WKGH7%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22lastModifiedByUser%22%3A%7B%22id%22%3A1497928%2C%22username%22%3A%22fkober%22%2C%22name%22%3A%22Frank%20Kober%22%2C%22links%22%3A%7B%22alternate%22%3A%7B%22href%22%3A%22https%3A%5C%2F%5C%2Fwww.zotero.org%5C%2Ffkober%22%2C%22type%22%3A%22text%5C%2Fhtml%22%7D%7D%7D%2C%22creatorSummary%22%3A%22Montoya%20et%20al.%22%2C%22parsedDate%22%3A%222016-05%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BMontoya%2C%20J.%2C%20Matta%2C%20N.B.%2C%20Suchon%2C%20P.%2C%20Guzian%2C%20M.C.%2C%20Lambert%2C%20N.C.%2C%20Mattei%2C%20J.P.%2C%20Guis%2C%20S.%2C%20Breban%2C%20M.%2C%20Roudier%2C%20J.%20and%20Balandraud%2C%20N.%20%282016%29%20%26%23x201C%3BPatients%20with%20ankylosing%20spondylitis%20have%20been%20breast%20fed%20less%20often%20than%20healthy%20controls%3A%20a%20case-control%20retrospective%20study%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BAnnals%20of%20the%20Rheumatic%20Diseases%26lt%3B%5C%2Fi%26gt%3B%2C%2075%285%29%2C%20pp.%20879%26%23x2013%3B882.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fannrheumdis-2015-208187%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fannrheumdis-2015-208187%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Patients%20with%20ankylosing%20spondylitis%20have%20been%20breast%20fed%20less%20often%20than%20healthy%20controls%3A%20a%20case-control%20retrospective%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Montoya%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%20B.%22%2C%22lastName%22%3A%22Matta%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P.%22%2C%22lastName%22%3A%22Suchon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%20C.%22%2C%22lastName%22%3A%22Guzian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%20C.%22%2C%22lastName%22%3A%22Lambert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%20P.%22%2C%22lastName%22%3A%22Mattei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Guis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Breban%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Roudier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%22%2C%22lastName%22%3A%22Balandraud%22%7D%5D%2C%22abstractNote%22%3A%22OBJECTIVE%3A%20Ankylosing%20spondylitis%20%28AS%29%20is%20a%20chronic%20inflammatory%20disease%20affecting%20the%20spine%20and%20pelvis%20of%20young%20adults.%20On%20the%20HLA-B27%20genetic%20background%2C%20the%20occurrence%20of%20AS%20is%20influenced%20by%20the%20intestinal%20microbiota.%20The%20goal%20of%20our%20study%20was%20to%20test%20whether%20breast%20feeding%2C%20which%20influences%20microbiota%2C%20can%20prevent%20the%20development%20of%20AS.%5CnMETHODS%3A%20First%2C%20203%20patients%20with%20HLA-B27-positive%20AS%20fulfilling%20the%20modified%20New%20York%20criteria%20were%20recruited%20in%20the%20Department%20of%20Rheumatology%2C%20Ste%20Marguerite%20hospital%20in%20Marseilles.%20A%20total%20of%20293%20healthy%20siblings%20were%20also%20recruited%20to%20make%20up%20a%20control%20group%20within%20the%20same%20families.%20Second%2C%20280%20healthy%20controls%2C%20and%20100%20patients%20with%20rheumatoid%20arthritis%20and%20their%20siblings%20were%20recruited.%20The%20data%20collected%20were%20age%2C%20gender%2C%20number%20of%20brothers%20and%20sisters%2C%20age%20at%20disease%20onset%2C%20type%20and%20duration%20of%20feeding%20%28breast%20or%20bottle%29.%5CnRESULTS%3A%20Patients%20with%20AS%20had%20been%20breast%20fed%20less%20often%20than%20healthy%20controls.%20In%20families%20where%20children%20were%20breast%20fed%2C%20the%20patients%20with%20AS%20were%20less%20often%20breast%20fed%20than%20their%20healthy%20siblings%20%2857%25%20vs%2072%25%29%2C%20giving%20an%20OR%20for%20AS%20onset%20of%200.53%20%2895%25%20CI%20%280.36%20to%200.77%29%2C%20p%20value%3D0.0009%29.%20Breast%20feeding%20reduced%20familial%20prevalence%20of%20AS.%20The%20frequency%20of%20breast%20feeding%20was%20similar%20in%20the%20AS%20siblings%20and%20in%20the%20280%20unrelated%20controls.%20However%2C%20patients%20with%20AS%20were%20less%20often%20breast%20fed%20compared%20with%20the%20280%20unrelated%20controls%20%28OR%200.6%2C%2095%25%20CI%20%280.42%20to%200.89%29%2C%20p%26lt%3B0.01%29.%5CnCONCLUSIONS%3A%20Our%20study%20suggests%20a%20breastfeeding-induced%20protective%20effect%20on%20the%20occurrence%20of%20AS.%20To%20our%20knowledge%2C%20this%20is%20the%20first%20study%20of%20breastfeeding%20history%20in%20patients%20with%20AS.%22%2C%22date%22%3A%222016-05%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1136%5C%2Fannrheumdis-2015-208187%22%2C%22ISSN%22%3A%221468-2060%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22LPVXE8S8%22%5D%2C%22dateModified%22%3A%222022-01-26T19%3A46%3A37Z%22%7D%7D%2C%7B%22key%22%3A%22FH87PZ45%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Le%20Troter%20et%20al.%22%2C%22parsedDate%22%3A%222016-04%22%2C%22numChildren%22%3A3%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BLe%20Troter%2C%20A.%2C%20Four%26%23xE9%3B%2C%20A.%2C%20Guye%2C%20M.%2C%20Confort-Gouny%2C%20S.%2C%20Mattei%2C%20J.-P.%2C%20Gondin%2C%20J.%2C%20Salort-Campana%2C%20E.%20and%20Bendahan%2C%20D.%20%282016%29%20%26%23x201C%3BVolume%20measurements%20of%20individual%20muscles%20in%20human%20quadriceps%20femoris%20using%20atlas-based%20segmentation%20approaches%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BMagma%20%28New%20York%2C%20N.Y.%29%26lt%3B%5C%2Fi%26gt%3B%2C%2029%282%29%2C%20pp.%20245%26%23x2013%3B257.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs10334-016-0535-6%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs10334-016-0535-6%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Volume%20measurements%20of%20individual%20muscles%20in%20human%20quadriceps%20femoris%20using%20atlas-based%20segmentation%20approaches%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Arnaud%22%2C%22lastName%22%3A%22Le%20Troter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandre%22%2C%22lastName%22%3A%22Four%5Cu00e9%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maxime%22%2C%22lastName%22%3A%22Guye%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylviane%22%2C%22lastName%22%3A%22Confort-Gouny%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Pierre%22%2C%22lastName%22%3A%22Mattei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julien%22%2C%22lastName%22%3A%22Gondin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Salort-Campana%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Bendahan%22%7D%5D%2C%22abstractNote%22%3A%22OBJECTIVES%3A%20Atlas-based%20segmentation%20is%20a%20powerful%20method%20for%20automatic%20structural%20segmentation%20of%20several%20sub-structures%20in%20many%20organs.%20However%2C%20such%20an%20approach%20has%20been%20very%20scarcely%20used%20in%20the%20context%20of%20muscle%20segmentation%2C%20and%20so%20far%20no%20study%20has%20assessed%20such%20a%20method%20for%20the%20automatic%20delineation%20of%20individual%20muscles%20of%20the%20quadriceps%20femoris%20%28QF%29.%20In%20the%20present%20study%2C%20we%20have%20evaluated%20a%20fully%20automated%20multi-atlas%20method%20and%20a%20semi-automated%20single-atlas%20method%20for%20the%20segmentation%20and%20volume%20quantification%20of%20the%20four%20muscles%20of%20the%20QF%20and%20for%20the%20QF%20as%20a%20whole.%5CnSUBJECTS%20AND%20METHODS%3A%20The%20study%20was%20conducted%20in%2032%20young%20healthy%20males%2C%20using%20high-resolution%20magnetic%20resonance%20images%20%28MRI%29%20of%20the%20thigh.%20The%20multi-atlas-based%20segmentation%20method%20was%20conducted%20in%2025%20subjects.%20Different%20non-linear%20registration%20approaches%20based%20on%20free-form%20deformable%20%28FFD%29%20and%20symmetric%20diffeomorphic%20normalization%20algorithms%20%28SyN%29%20were%20assessed.%20Optimal%20parameters%20of%20two%20fusion%20methods%2C%20i.e.%2C%20STAPLE%20and%20STEPS%2C%20were%20determined%20on%20the%20basis%20of%20the%20highest%20Dice%20similarity%20index%20%28DSI%29%20considering%20manual%20segmentation%20%28MSeg%29%20as%20the%20ground%20truth.%20Validation%20and%20reproducibility%20of%20this%20pipeline%20were%20determined%20using%20another%20MRI%20dataset%20recorded%20in%20seven%20healthy%20male%20subjects%20on%20the%20basis%20of%20additional%20metrics%20such%20as%20the%20muscle%20volume%20similarity%20values%2C%20intraclass%20coefficient%2C%20and%20coefficient%20of%20variation.%20Both%20non-linear%20registration%20methods%20%28FFD%20and%20SyN%29%20were%20also%20evaluated%20as%20part%20of%20a%20single-atlas%20strategy%20in%20order%20to%20assess%20longitudinal%20muscle%20volume%20measurements.%20The%20multi-%20and%20the%20single-atlas%20approaches%20were%20compared%20for%20the%20segmentation%20and%20the%20volume%20quantification%20of%20the%20four%20muscles%20of%20the%20QF%20and%20for%20the%20QF%20as%20a%20whole.%5CnRESULTS%3A%20Considering%20each%20muscle%20of%20the%20QF%2C%20the%20DSI%20of%20the%20multi-atlas-based%20approach%20was%20high%200.87%5Cu00a0%5Cu00b1%5Cu00a00.11%20and%20the%20best%20results%20were%20obtained%20with%20the%20combination%20of%20two%20deformation%20fields%20resulting%20from%20the%20SyN%20registration%20method%20and%20the%20STEPS%20fusion%20algorithm.%20The%20optimal%20variables%20for%20FFD%20and%20SyN%20registration%20methods%20were%20four%20templates%20and%20a%20kernel%20standard%20deviation%20ranging%20between%205%20and%208.%20The%20segmentation%20process%20using%20a%20single-atlas-based%20method%20was%20more%20robust%20with%20DSI%20values%20higher%20than%200.9.%20From%20the%20vantage%20of%20muscle%20volume%20measurements%2C%20the%20multi-atlas-based%20strategy%20provided%20acceptable%20results%20regarding%20the%20QF%20muscle%20as%20a%20whole%20but%20highly%20variable%20results%20regarding%20individual%20muscle.%20On%20the%20contrary%2C%20the%20performance%20of%20the%20single-atlas-based%20pipeline%20for%20individual%20muscles%20was%20highly%20comparable%20to%20the%20MSeg%2C%20thereby%20indicating%20that%20this%20method%20would%20be%20adequate%20for%20longitudinal%20tracking%20of%20muscle%20volume%20changes%20in%20healthy%20subjects.%5CnCONCLUSION%3A%20In%20the%20present%20study%2C%20we%20demonstrated%20that%20both%20multi-atlas%20and%20single-atlas%20approaches%20were%20relevant%20for%20the%20segmentation%20of%20individual%20muscles%20of%20the%20QF%20in%20healthy%20subjects.%20Considering%20muscle%20volume%20measurements%2C%20the%20single-atlas%20method%20provided%20promising%20perspectives%20regarding%20longitudinal%20quantification%20of%20individual%20muscle%20volumes.%22%2C%22date%22%3A%22Apr%202016%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1007%5C%2Fs10334-016-0535-6%22%2C%22ISSN%22%3A%221352-8661%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%226XQENTHJ%22%2C%227JR7EDKF%22%2C%22NW6SZQBR%22%2C%226M38MJ3E%22%2C%225P5FWCR9%22%2C%22XTA6KS7L%22%5D%2C%22dateModified%22%3A%222024-09-16T13%3A08%3A40Z%22%7D%7D%2C%7B%22key%22%3A%22TJJJ4DVZ%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22lastModifiedByUser%22%3A%7B%22id%22%3A1497928%2C%22username%22%3A%22fkober%22%2C%22name%22%3A%22Frank%20Kober%22%2C%22links%22%3A%7B%22alternate%22%3A%7B%22href%22%3A%22https%3A%5C%2F%5C%2Fwww.zotero.org%5C%2Ffkober%22%2C%22type%22%3A%22text%5C%2Fhtml%22%7D%7D%7D%2C%22creatorSummary%22%3A%22Four%5Cu00e9%20et%20al.%22%2C%22parsedDate%22%3A%222016-02%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BFour%26%23xE9%3B%2C%20A.%2C%20Nosaka%2C%20K.%2C%20Gastaldi%2C%20M.%2C%20Mattei%2C%20J.-P.%2C%20Boudinet%2C%20H.%2C%20Guye%2C%20M.%2C%20Vilmen%2C%20C.%2C%20Le%20Fur%2C%20Y.%2C%20Bendahan%2C%20D.%20and%20Gondin%2C%20J.%20%282016%29%20%26%23x201C%3BEffects%20of%20branched-chain%20amino%20acids%20supplementation%20on%20both%20plasma%20amino%20acids%20concentration%20and%20muscle%20energetics%20changes%20resulting%20from%20muscle%20damage%3A%20A%20randomized%20placebo%20controlled%20trial%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BClinical%20Nutrition%20%28Edinburgh%2C%20Scotland%29%26lt%3B%5C%2Fi%26gt%3B%2C%2035%281%29%2C%20pp.%2083%26%23x2013%3B94.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.clnu.2015.03.014%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.clnu.2015.03.014%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Effects%20of%20branched-chain%20amino%20acids%20supplementation%20on%20both%20plasma%20amino%20acids%20concentration%20and%20muscle%20energetics%20changes%20resulting%20from%20muscle%20damage%3A%20A%20randomized%20placebo%20controlled%20trial%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandre%22%2C%22lastName%22%3A%22Four%5Cu00e9%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kazunori%22%2C%22lastName%22%3A%22Nosaka%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marguerite%22%2C%22lastName%22%3A%22Gastaldi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Pierre%22%2C%22lastName%22%3A%22Mattei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22H%5Cu00e9l%5Cu00e8ne%22%2C%22lastName%22%3A%22Boudinet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maxime%22%2C%22lastName%22%3A%22Guye%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christophe%22%2C%22lastName%22%3A%22Vilmen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yann%22%2C%22lastName%22%3A%22Le%20Fur%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Bendahan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julien%22%2C%22lastName%22%3A%22Gondin%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%20%26amp%3B%20AIMS%3A%20Branched-chain%20amino%20acids%20promote%20muscle-protein%20synthesis%2C%20reduce%20protein%20oxidation%20and%20have%20positive%20effects%20on%20mitochondrial%20biogenesis%20and%20reactive%20oxygen%20species%20scavenging.%20The%20purpose%20of%20the%20study%20was%20to%20determine%20the%20potential%20benefits%20of%20branched-chain%20amino%20acids%20supplementation%20on%20changes%20in%20force%20capacities%2C%20plasma%20amino%20acids%20concentration%20and%20muscle%20metabolic%20alterations%20after%20exercise-induced%20muscle%20damage.%5CnMETHODS%3A%20%2831%29P%20magnetic%20resonance%20spectroscopy%20and%20biochemical%20analyses%20were%20used%20to%20follow%20the%20changes%20after%20such%20damage.%20Twenty%20six%20young%20healthy%20men%20were%20randomly%20assigned%20to%20supplemented%20branched-chain%20amino%20acids%20or%20placebo%20group.%20Knee%20extensors%20maximal%20voluntary%20isometric%20force%20was%20assessed%20before%20and%20on%20four%20days%20following%20exercise-induced%20muscle%20damage.%20Concentrations%20in%20phosphocreatine%20%5BPCr%5D%2C%20inorganic%20phosphate%20%5BPi%5D%20and%20pH%20were%20measured%20during%20a%20standardized%20rest-exercise-recovery%20protocol%20before%2C%20two%20%28D2%29%20and%20four%20%28D4%29%20days%20after%20exercise-induced%20muscle%20damage.%5CnRESULTS%3A%20No%20significant%20difference%20between%20groups%20was%20found%20for%20changes%20in%20maximal%20voluntary%20isometric%20force%20%28-24%25%20at%20D2%20and%5Cu00a0-21%25%20at%20D4%29.%20Plasma%20alanine%20concentration%20significantly%20increased%20immediately%20after%20exercise-induced%20muscle%20damage%20%28%2B25%25%29%20in%20both%20groups%20while%20concentrations%20in%20glycine%2C%20histidine%2C%20phenylalanine%20and%20tyrosine%20decreased.%20No%20difference%20between%20groups%20was%20found%20in%20the%20increased%20resting%20%5BPi%5D%20%28%2B42%25%20at%20D2%20and%5Cu00a0%2B34%25%20at%20D4%29%2C%20decreased%20resting%20pH%20%28-0.04%5Cu00a0at%20D2%20and%5Cu00a0-0.03%20at%20D4%29%20and%20the%20slower%20PCr%20recovery%20rate%20%28-18%25%20at%20D2%20and%5Cu00a0-24%25%20at%20D4%29.%5CnCONCLUSIONS%3A%20The%20damaged%20muscle%20was%20not%20able%20to%20get%20benefits%20out%20of%20the%20increased%20plasma%20branched-chain%20amino%20acids%20availability%20to%20attenuate%20changes%20in%20indirect%20markers%20of%20muscle%20damage%20and%20muscle%20metabolic%20alterations%20following%20exercise-induced%20muscle%20damage.%22%2C%22date%22%3A%22Feb%202016%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.clnu.2015.03.014%22%2C%22ISSN%22%3A%221532-1983%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22SVI8UJ6H%22%2C%226XQENTHJ%22%2C%227FK4UDH9%22%2C%22NW6SZQBR%22%2C%226M38MJ3E%22%2C%22XTA6KS7L%22%5D%2C%22dateModified%22%3A%222024-09-16T13%3A08%3A34Z%22%7D%7D%2C%7B%22key%22%3A%22W528J5LM%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22lastModifiedByUser%22%3A%7B%22id%22%3A1497928%2C%22username%22%3A%22fkober%22%2C%22name%22%3A%22Frank%20Kober%22%2C%22links%22%3A%7B%22alternate%22%3A%7B%22href%22%3A%22https%3A%5C%2F%5C%2Fwww.zotero.org%5C%2Ffkober%22%2C%22type%22%3A%22text%5C%2Fhtml%22%7D%7D%7D%2C%22creatorSummary%22%3A%22Zink%20et%20al.%22%2C%22parsedDate%22%3A%222015-09-18%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BZink%2C%20J.-V.%2C%20Souteyrand%2C%20P.%2C%20Guis%2C%20S.%2C%20Chagnaud%2C%20C.%2C%20Fur%2C%20Y.L.%2C%20Militianu%2C%20D.%2C%20Mattei%2C%20J.-P.%2C%20Rozenbaum%2C%20M.%2C%20Rosner%2C%20I.%2C%20Guye%2C%20M.%2C%20Bernard%2C%20M.%20and%20Bendahan%2C%20D.%20%282015%29%20%26%23x201C%3BStandardized%20quantitative%20measurements%20of%20wrist%20cartilage%20in%20healthy%20humans%20using%203T%20magnetic%20resonance%20imaging%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BWorld%20Journal%20of%20Orthopedics%26lt%3B%5C%2Fi%26gt%3B%2C%206%288%29%2C%20pp.%20641%26%23x2013%3B648.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.5312%5C%2Fwjo.v6.i8.641%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.5312%5C%2Fwjo.v6.i8.641%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Standardized%20quantitative%20measurements%20of%20wrist%20cartilage%20in%20healthy%20humans%20using%203T%20magnetic%20resonance%20imaging%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Vincent%22%2C%22lastName%22%3A%22Zink%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philippe%22%2C%22lastName%22%3A%22Souteyrand%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sandrine%22%2C%22lastName%22%3A%22Guis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christophe%22%2C%22lastName%22%3A%22Chagnaud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yann%20Le%22%2C%22lastName%22%3A%22Fur%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniela%22%2C%22lastName%22%3A%22Militianu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Pierre%22%2C%22lastName%22%3A%22Mattei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Rozenbaum%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Itzhak%22%2C%22lastName%22%3A%22Rosner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maxime%22%2C%22lastName%22%3A%22Guye%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Monique%22%2C%22lastName%22%3A%22Bernard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Bendahan%22%7D%5D%2C%22abstractNote%22%3A%22AIM%3A%20To%20quantify%20the%20wrist%20cartilage%20cross-sectional%20area%20in%20humans%20from%20a%203D%20magnetic%20resonance%20imaging%20%28MRI%29%20dataset%20and%20to%20assess%20the%20corresponding%20reproducibility.%5CnMETHODS%3A%20The%20study%20was%20conducted%20in%2014%20healthy%20volunteers%20%286%20females%20and%208%20males%29%20between%2030%20and%2058%20years%20old%20and%20devoid%20of%20articular%20pain.%20Subjects%20were%20asked%20to%20lie%20down%20in%20the%20supine%20position%20with%20the%20right%20hand%20positioned%20above%20the%20pelvic%20region%20on%20top%20of%20a%20home-built%20rigid%20platform%20attached%20to%20the%20scanner%20bed.%20The%20wrist%20was%20wrapped%20with%20a%20flexible%20surface%20coil.%20MRI%20investigations%20were%20performed%20at%203T%20%28Verio-Siemens%29%20using%20volume%20interpolated%20breath%20hold%20examination%20%28VIBE%29%20and%20dual%20echo%20steady%20state%20%28DESS%29%20MRI%20sequences.%20Cartilage%20cross%20sectional%20area%20%28CSA%29%20was%20measured%20on%20a%20slice%20of%20interest%20selected%20from%20a%203D%20dataset%20of%20the%20entire%20carpus%20and%20metacarpal-phalangeal%20areas%20on%20the%20basis%20of%20anatomical%20criteria%20using%20conventional%20image%20processing%20radiology%20software.%20Cartilage%20cross-sectional%20areas%20between%20opposite%20bones%20in%20the%20carpal%20region%20were%20manually%20selected%20and%20quantified%20using%20a%20thresholding%20method.%5CnRESULTS%3A%20Cartilage%20CSA%20measurements%20performed%20on%20a%20selected%20predefined%20slice%20were%20292.4%20%5Cu00b1%2039%20mm%282%29%20using%20the%20VIBE%20sequence%20and%20slightly%20lower%2C%20270.4%20%5Cu00b1%2050.6%20mm%282%29%2C%20with%20the%20DESS%20sequence.%20The%20inter%20%2814.1%25%29%20and%20intra%20%282.4%25%29%20subject%20variability%20was%20similar%20for%20both%20MRI%20methods.%20The%20coefficients%20of%20variation%20computed%20for%20the%20repeated%20measurements%20were%20also%20comparable%20for%20the%20VIBE%20%282.4%25%29%20and%20the%20DESS%20%284.8%25%29%20sequences.%20The%20carpus%20length%20averaged%20over%20the%20group%20was%2037.5%20%5Cu00b1%202.8%20mm%20with%20a%207.45%25%20between-subjects%20coefficient%20of%20variation.%20Of%20note%2C%20wrist%20cartilage%20CSA%20measured%20with%20either%20the%20VIBE%20or%20the%20DESS%20sequences%20was%20linearly%20related%20to%20the%20carpal%20bone%20length.%20The%20variability%20between%20subjects%20was%20significantly%20reduced%20to%208.4%25%20when%20the%20CSA%20was%20normalized%20with%20respect%20to%20the%20carpal%20bone%20length.%5CnCONCLUSION%3A%20The%20ratio%20between%20wrist%20cartilage%20CSA%20and%20carpal%20bone%20length%20is%20a%20highly%20reproducible%20standardized%20measurement%20which%20normalizes%20the%20natural%20diversity%20between%20individuals.%22%2C%22date%22%3A%222015-09-18%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.5312%5C%2Fwjo.v6.i8.641%22%2C%22ISSN%22%3A%222218-5836%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22NW6SZQBR%22%5D%2C%22dateModified%22%3A%222023-06-26T07%3A49%3A46Z%22%7D%7D%2C%7B%22key%22%3A%2266RKWJKT%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Wegrzyk%20et%20al.%22%2C%22parsedDate%22%3A%222015-07%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BWegrzyk%2C%20J.%2C%20Foure%2C%20A.%2C%20Vilmen%2C%20C.%2C%20Ghattas%2C%20B.%2C%20Maffiuletti%2C%20N.A.%2C%20Mattei%2C%20J.-P.%2C%20Place%2C%20N.%2C%20Bendahan%2C%20D.%20and%20Gondin%2C%20J.%20%282015%29%20%26%23x201C%3BExtra%20Forces%20induced%20by%20wide-pulse%2C%20high-frequency%20electrical%20stimulation%3A%20Occurrence%2C%20magnitude%2C%20variability%20and%20underlying%20mechanisms%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BClinical%20Neurophysiology%26lt%3B%5C%2Fi%26gt%3B%2C%20126%287%29%2C%20pp.%201400%26%23x2013%3B1412.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.clinph.2014.10.001%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.clinph.2014.10.001%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Extra%20Forces%20induced%20by%20wide-pulse%2C%20high-frequency%20electrical%20stimulation%3A%20Occurrence%2C%20magnitude%2C%20variability%20and%20underlying%20mechanisms%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jennifer%22%2C%22lastName%22%3A%22Wegrzyk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandre%22%2C%22lastName%22%3A%22Foure%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christophe%22%2C%22lastName%22%3A%22Vilmen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Badih%22%2C%22lastName%22%3A%22Ghattas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicola%20A.%22%2C%22lastName%22%3A%22Maffiuletti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Pierre%22%2C%22lastName%22%3A%22Mattei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Place%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Bendahan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julien%22%2C%22lastName%22%3A%22Gondin%22%7D%5D%2C%22abstractNote%22%3A%22Objective%3A%20In%20contrast%20to%20conventional%20%28CONV%29%20neuromuscular%20electrical%20stimulation%20%28NMES%29%2C%20the%20use%20of%20%26quot%3Bwide-pulse%2C%20high-frequencies%26quot%3B%20%28WPHF%29%20can%20generate%20higher%20forces%20than%20expected%20by%20the%20direct%20activation%20of%20motor%20axons%20alone.%20We%20aimed%20at%20investigating%20the%20occurrence%2C%20magnitude%2C%20variability%20and%20underlying%20neuromuscular%20mechanisms%20of%20these%20%26quot%3BExtra%20Forces%26quot%3B%20%28EF%29.%20Methods%3A%20Electrically-evoked%20isometric%20plantar%20flexion%20force%20was%20recorded%20in%2042%20healthy%20subjects.%20Additionally%2C%20twitch%20potentiation%2C%20H-reflex%20and%20M-wave%20responses%20were%20assessed%20in%2013%20participants.%20CONV%20%2825%20Hz%2C%200.05%20ms%29%20and%20WPHF%20%28100%20Hz%2C%201%20ms%29%20NMES%20consisted%20of%20five%20stimulation%20trains%20%2820%20s%20on-90%20s%20off%29.%20Results%3A%20K-means%20clustering%20analysis%20disclosed%20a%20responder%20rate%20of%20almost%2060%25.%20Within%20this%20group%20of%20responders%2C%20force%20significantly%20increased%20from%204%25%20to%2016%25%20of%20the%20maximal%20voluntary%20contraction%20force%20and%20H-reflexes%20were%20depressed%20after%20WPHF%20NMES.%20In%20contrast%2C%20non-responders%20showed%20neither%20EF%20nor%20H-reflex%20depression.%20Twitch%20potentiation%20and%20resting%20EMG%20data%20were%20similar%20between%20groups.%20Interestingly%2C%20a%20large%20inter-and%20intrasubject%20variability%20of%20EF%20was%20observed.%20Conclusion%3A%20The%20responder%20percentage%20was%20overestimated%20in%20previous%20studies.%20Significance%3A%20This%20study%20proposes%20a%20novel%20methodological%20framework%20for%20unraveling%20the%20neurophysiological%20mechanisms%20involved%20in%20EF%20and%20provides%20further%20evidence%20for%20a%20central%20contribution%20to%20EF%20in%20responders.%20%28C%29%202014%20International%20Federation%20of%20Clinical%20Neurophysiology.%20Published%20by%20Elsevier%20Ireland%20Ltd.%20All%20rights%20reserved.%22%2C%22date%22%3A%22JUL%202015%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.clinph.2014.10.001%22%2C%22ISSN%22%3A%221388-2457%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%226XQENTHJ%22%2C%227FK4UDH9%22%2C%22NW6SZQBR%22%2C%226M38MJ3E%22%2C%22SXWA9VN6%22%5D%2C%22dateModified%22%3A%222024-12-13T09%3A15%3A27Z%22%7D%7D%2C%7B%22key%22%3A%2247SX8Q8H%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Four%5Cu00e9%20et%20al.%22%2C%22parsedDate%22%3A%222015-06%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BFour%26%23xE9%3B%2C%20A.%2C%20Wegrzyk%2C%20J.%2C%20LE%20Fur%2C%20Y.%2C%20Mattei%2C%20J.-P.%2C%20Boudinet%2C%20H.%2C%20Vilmen%2C%20C.%2C%20Bendahan%2C%20D.%20and%20Gondin%2C%20J.%20%282015%29%20%26%23x201C%3BImpaired%20mitochondrial%20function%20and%20reduced%20energy%20cost%20as%20a%20result%20of%20muscle%20damage%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BMedicine%20and%20Science%20in%20Sports%20and%20Exercise%26lt%3B%5C%2Fi%26gt%3B%2C%2047%286%29%2C%20pp.%201135%26%23x2013%3B1144.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1249%5C%2FMSS.0000000000000523%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1249%5C%2FMSS.0000000000000523%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Impaired%20mitochondrial%20function%20and%20reduced%20energy%20cost%20as%20a%20result%20of%20muscle%20damage%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandre%22%2C%22lastName%22%3A%22Four%5Cu00e9%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jennifer%22%2C%22lastName%22%3A%22Wegrzyk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yann%22%2C%22lastName%22%3A%22LE%20Fur%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Pierre%22%2C%22lastName%22%3A%22Mattei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22H%5Cu00e9l%5Cu00e8ne%22%2C%22lastName%22%3A%22Boudinet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christophe%22%2C%22lastName%22%3A%22Vilmen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Bendahan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julien%22%2C%22lastName%22%3A%22Gondin%22%7D%5D%2C%22abstractNote%22%3A%22PURPOSE%3A%20Although%20it%20has%20been%20largely%20acknowledged%20that%20isometric%20neuromuscular%20electrostimulation%20%28NMES%29%20exercise%20induces%20larger%20muscle%20damage%20than%20voluntary%20contractions%2C%20the%20corresponding%20effects%20on%20muscle%20energetics%20remain%20to%20be%20determined.%20Voluntary%20exercise-induced%20muscle%20damage%20%28EIMD%29%20has%20been%20reported%20to%20have%20minor%20slight%20effects%20on%20muscle%20metabolic%20response%20to%20subsequent%20dynamic%20exercise%2C%20but%20the%20magnitude%20of%20muscle%20energetics%20alterations%20for%20NMES%20EIMD%20has%20never%20been%20documented.%5CnMETHODS%3A%20P%20magnetic%20resonance%20spectroscopy%20measurements%20were%20performed%20in%2013%20young%20healthy%20males%20during%20a%20standardized%20rest-exercise-recovery%20protocol%20before%20%28D0%29%20and%202%20d%20%28D2%29%20and%204%20d%20%28D4%29%20after%20NMES%20EIMD%20on%20knee%20extensor%20muscles.%20Changes%20in%20kinetics%20of%20phosphorylated%20metabolite%20concentrations%20%28i.e.%2C%20phosphocreatine%20%5BPCr%5D%2C%20inorganic%20phosphate%20%5BPi%5D%2C%20and%20adenosine%20triphosphate%20%5BATP%5D%29%20and%20pH%20were%20assessed%20to%20investigate%20aerobic%20and%20anaerobic%20rates%20of%20ATP%20production%20and%20energy%20cost%20of%20contraction%20%28Ec%29.%5CnRESULTS%3A%20Resting%20%5BPi%5D%5C%2F%5BPCr%5D%20ratio%20increased%20at%20D2%20%28%2B39%25%29%20and%20D4%20%28%2B29%25%29%2C%20mainly%20owing%20to%20the%20increased%20%5BPi%5D%20%28%2B43%25%20and%20%2B32%25%2C%20respectively%29%2C%20whereas%20a%20significant%20decrease%20in%20resting%20pH%20was%20determined%20%28-0.04%20pH%20unit%20and%20-0.03%20pH%20unit%2C%20respectively%29.%20PCr%20recovery%20rate%20decreased%20at%20D2%20%28-21%25%29%20and%20D4%20%28-23%25%29%20in%20conjunction%20with%20a%20significantly%20decreased%20total%20rate%20of%20ATP%20production%20at%20D4%20%28-18%25%29%20mainly%20owing%20to%20an%20altered%20aerobic%20ATP%20production%20%28-19%25%29.%20Paradoxically%2C%20Ec%20was%20decreased%20at%20D4%20%28-21%25%29.%5CnCONCLUSION%3A%20Overall%2C%20NMES%20EIMD%20led%20to%20intramuscular%20acidosis%20in%20resting%20muscle%20and%20mitochondrial%20impairment%20in%20exercising%20muscle.%20Alterations%20of%20noncontractile%20processes%20and%5C%2For%20adaptive%20mechanisms%20to%20muscle%20damage%20might%20account%20for%20the%20decreased%20Ec%20during%20the%20dynamic%20exercise.%22%2C%22date%22%3A%22Jun%202015%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1249%5C%2FMSS.0000000000000523%22%2C%22ISSN%22%3A%221530-0315%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22SVI8UJ6H%22%2C%226XQENTHJ%22%2C%227FK4UDH9%22%2C%22NW6SZQBR%22%2C%226M38MJ3E%22%2C%22SXWA9VN6%22%5D%2C%22dateModified%22%3A%222024-12-13T09%3A12%3A44Z%22%7D%7D%2C%7B%22key%22%3A%22G6CJD2TP%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Jubeau%20et%20al.%22%2C%22parsedDate%22%3A%222015-05%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BJubeau%2C%20M.%2C%20LE%20Fur%2C%20Y.%2C%20Duhamel%2C%20G.%2C%20Wegrzyk%2C%20J.%2C%20Confort-Gouny%2C%20S.%2C%20Vilmen%2C%20C.%2C%20Cozzone%2C%20P.J.%2C%20Mattei%2C%20J.P.%2C%20Bendahan%2C%20D.%20and%20Gondin%2C%20J.%20%282015%29%20%26%23x201C%3BLocalized%20metabolic%20and%20t2%20changes%20induced%20by%20voluntary%20and%20evoked%20contractions%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BMedicine%20and%20Science%20in%20Sports%20and%20Exercise%26lt%3B%5C%2Fi%26gt%3B%2C%2047%285%29%2C%20pp.%20921%26%23x2013%3B930.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1249%5C%2FMSS.0000000000000491%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1249%5C%2FMSS.0000000000000491%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Localized%20metabolic%20and%20t2%20changes%20induced%20by%20voluntary%20and%20evoked%20contractions%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marc%22%2C%22lastName%22%3A%22Jubeau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yann%22%2C%22lastName%22%3A%22LE%20Fur%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guillaume%22%2C%22lastName%22%3A%22Duhamel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jennifer%22%2C%22lastName%22%3A%22Wegrzyk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylviane%22%2C%22lastName%22%3A%22Confort-Gouny%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christophe%22%2C%22lastName%22%3A%22Vilmen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Patrick%20J.%22%2C%22lastName%22%3A%22Cozzone%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean%20Pierre%22%2C%22lastName%22%3A%22Mattei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Bendahan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julien%22%2C%22lastName%22%3A%22Gondin%22%7D%5D%2C%22abstractNote%22%3A%22PURPOSE%3A%20This%20study%20compared%20the%20metabolic%20and%20activation%20changes%20induced%20by%20electrically%20evoked%20%28neuromuscular%20electrical%20stimulation%20%28NMES%29%29%20and%20voluntary%20%28VOL%29%20contractions%20performed%20at%20the%20same%20submaximal%20intensity%20using%20P%20chemical%20shift%20imaging%20%28CSI%29%20and%20T2%20mapping%20investigations.%5CnMETHODS%3A%20Fifteen%20healthy%20subjects%20were%20asked%20to%20perform%20both%20NMES%20and%20VOL%20protocols%20with%20the%20knee%20extensors%20%28i.e.%2C%20232%20isometric%20contractions%20at%2030%25%20of%20maximal%20force%29%20inside%20a%203-T%20scanner%20for%20two%20experimental%20sessions.%20During%20the%20first%20session%2C%20metabolic%20variations%2C%20i.e.%2C%20phosphocreatine%20%28PCr%29%2C%20inorganic%20phosphate%20%28Pi%29%2C%20and%20pH%2C%20were%20recorded%20using%20localized%20P%20CSI.%20During%20a%20second%20session%2C%20T2%20maps%20of%20the%20knee%20extensors%20were%20obtained%20at%20rest%20and%20immediately%20after%20each%20exercise.%20Voxels%20of%20interest%20were%20selected%20from%20the%20directly%20stimulated%20vastus%20lateralis%20and%20from%20the%20nondirectly%20stimulated%20rectus%20femoris%5C%2Fvastus%20intermedius%20muscles.%5CnRESULTS%3A%20PCr%20depletion%20recorded%20throughout%20the%20NMES%20session%20was%20significantly%20larger%20in%20the%20vastus%20lateralis%20as%20compared%20with%20the%20rectus%20femoris%5C%2Fvastus%20intermedius%20muscles%20for%20both%20conditions%20%28VOL%20and%20NMES%29.%20A%20higher%20occurrence%20of%20Pi%20splitting%20and%20a%20greater%20acidosis%20was%20found%20during%20NMES%20as%20compared%20with%20VOL%20exercise%2C%20illustrating%20the%20heterogeneous%20activation%20of%20both%20slow%20and%20fast%20muscle%20fibers.%20T2%20changes%20were%20greater%20after%20NMES%20as%20compared%20with%20VOL%20for%20both%20muscles%20but%20were%20not%20necessarily%20related%20to%20the%20localized%20metabolic%20demand.%5CnCONCLUSION%3A%20We%20provided%20direct%20evidence%20that%20the%20metabolic%20demand%20was%20strongly%20related%20to%20both%20the%20exercise%20modality%20and%20the%20site%20of%20stimulation.%20On%20the%20basis%20of%20the%20occurrence%20of%20Pi%20splitting%2C%20we%20suggested%20that%20NMES%20can%20activate%20fast%20muscle%20fibers%20even%20at%20low%20force%20levels.%22%2C%22date%22%3A%22May%202015%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1249%5C%2FMSS.0000000000000491%22%2C%22ISSN%22%3A%221530-0315%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%224U7D3E9U%22%2C%22SVI8UJ6H%22%2C%226XQENTHJ%22%2C%227JR7EDKF%22%2C%227FK4UDH9%22%2C%22NW6SZQBR%22%2C%224ZGX55W3%22%2C%22SXWA9VN6%22%5D%2C%22dateModified%22%3A%222024-12-13T09%3A12%3A42Z%22%7D%7D%2C%7B%22key%22%3A%22QWZZ8KF7%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Four%5Cu00e9%20et%20al.%22%2C%22parsedDate%22%3A%222015-01%22%2C%22numChildren%22%3A3%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BFour%26%23xE9%3B%2C%20A.%2C%20Duhamel%2C%20G.%2C%20Wegrzyk%2C%20J.%2C%20Boudinet%2C%20H.%2C%20Mattei%2C%20J.-P.%2C%20Le%20Troter%2C%20A.%2C%20Bendahan%2C%20D.%20and%20Gondin%2C%20J.%20%282015%29%20%26%23x201C%3BHeterogeneity%20of%20muscle%20damage%20induced%20by%20electrostimulation%3A%20a%20multimodal%20MRI%20study%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BMedicine%20and%20Science%20in%20Sports%20and%20Exercise%26lt%3B%5C%2Fi%26gt%3B%2C%2047%281%29%2C%20pp.%20166%26%23x2013%3B175.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1249%5C%2FMSS.0000000000000397%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1249%5C%2FMSS.0000000000000397%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Heterogeneity%20of%20muscle%20damage%20induced%20by%20electrostimulation%3A%20a%20multimodal%20MRI%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandre%22%2C%22lastName%22%3A%22Four%5Cu00e9%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guillaume%22%2C%22lastName%22%3A%22Duhamel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jennifer%22%2C%22lastName%22%3A%22Wegrzyk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22H%5Cu00e9l%5Cu00e8ne%22%2C%22lastName%22%3A%22Boudinet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Pierre%22%2C%22lastName%22%3A%22Mattei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Arnaud%22%2C%22lastName%22%3A%22Le%20Troter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Bendahan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julien%22%2C%22lastName%22%3A%22Gondin%22%7D%5D%2C%22abstractNote%22%3A%22PURPOSE%3A%20Neuromuscular%20electrostimulation%20%28NMES%29%20leads%20to%20a%20spatially%20fixed%2C%20synchronous%2C%20and%20superficial%20motor%20unit%20recruitment%2C%20which%20could%20induce%20muscle%20damage.%20Therefore%2C%20the%20extent%20of%20muscle%20damage%20and%20its%20spatial%20occurrence%20were%20expected%20to%20be%20heterogeneous%20across%20and%20along%20the%20quadriceps%20femoris%20%28QF%29%20muscles.%20The%20aim%20of%20the%20present%20study%20was%20to%20characterize%20muscle%20spatial%20heterogeneity%20in%20QF%20damage%20after%20a%20single%20bout%20of%20isometric%20NMES%20using%20multimodal%20magnetic%20resonance%20imaging%20%28MRI%29.%5CnMETHODS%3A%20Twenty-five%20young%20healthy%20males%20participated%20in%20this%20study.%20MRI%20investigations%20consisted%20of%20the%20assessment%20of%20muscle%20volume%2C%20transverse%20relaxation%20time%20%28T2%29%2C%20and%20diffusion%20tensor%20imaging%20%28DTI%29%20in%20muscles%20positioned%20near%20the%20stimulation%20electrodes%20%28i.e.%2C%20vastus%20lateralis%20%28VL%29%20and%20vastus%20medialis%20%28VM%29%29%20and%20muscles%20located%20outside%20the%20stimulated%20regions%20%28i.e.%2C%20vastus%20intermedius%20and%20rectus%20femoris%29.%20These%20measurements%20were%20performed%206%20d%20before%2C%20and%202%20d%20and%204%20d%20%28D4%29%20after%20the%20NMES%20session.%5CnRESULTS%3A%20For%20the%20muscles%20placed%20in%20direct%20contact%20with%20the%20stimulation%20electrodes%2C%20volume%20%28VL%2C%20%2B8.5%25%3B%20VM%2C%20%2B3.8%25%29%2C%20T2%20%28VL%2C%20%2B19.5%25%3B%20VM%2C%20%2B6.7%25%29%20and%20radial%20diffusivity%20%28%5Cu03bb3%29%20%28VL%2C%20%2B%207.3%25%3B%20VM%2C%20%2B3.7%25%29%20significantly%20increased%20at%20D4.%20Whereas%20MRI%20parameter%20changes%20were%20larger%20for%20VL%20as%20compared%20with%20those%20for%20other%20QF%20muscles%20at%20D4%2C%20homogeneous%20alterations%20were%20found%20along%20all%20QF%20muscles.%5CnCONCLUSIONS%3A%20Isometric%20NMES%20induced%20specific%20and%20localized%20alterations%20in%20VL%20and%20VM%2C%20with%20heterogeneous%20damage%20amplitude%20among%20them.%20Potential%20effects%20of%20unaccustomed%20intermuscle%20shear%20stress%20during%20electrically%20evoked%20isometric%20contractions%20could%20be%20a%20key%20factor%20in%20the%20spatial%20occurrence%20and%20the%20extent%20of%20damage%20among%20QF%20muscles%20%28especially%20in%20VL%29.%20The%20kinetics%20and%20extent%20of%20MRI%20changes%20varied%20between%20T2%20and%20diffusion%20tensor%20imaging%20metrics%2C%20suggesting%20the%20involvement%20of%20different%20physiological%20processes.%22%2C%22date%22%3A%22Jan%202015%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1249%5C%2FMSS.0000000000000397%22%2C%22ISSN%22%3A%221530-0315%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%224U7D3E9U%22%2C%226XQENTHJ%22%2C%22NW6SZQBR%22%2C%226M38MJ3E%22%2C%22SXWA9VN6%22%2C%225P5FWCR9%22%5D%2C%22dateModified%22%3A%222024-12-13T09%3A12%3A45Z%22%7D%7D%2C%7B%22key%22%3A%22266M33GB%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Wegrzyk%20et%20al.%22%2C%22parsedDate%22%3A%222015%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BWegrzyk%2C%20J.%2C%20Four%26%23xE9%3B%2C%20A.%2C%20Le%20Fur%2C%20Y.%2C%20Maffiuletti%2C%20N.A.%2C%20Vilmen%2C%20C.%2C%20Guye%2C%20M.%2C%20Mattei%2C%20J.-P.%2C%20Place%2C%20N.%2C%20Bendahan%2C%20D.%20and%20Gondin%2C%20J.%20%282015%29%20%26%23x201C%3BResponders%20to%20Wide-Pulse%2C%20High-Frequency%20Neuromuscular%20Electrical%20Stimulation%20Show%20Reduced%20Metabolic%20Demand%3A%20A%2031P-MRS%20Study%20in%20Humans%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BPloS%20One%26lt%3B%5C%2Fi%26gt%3B%2C%2010%2811%29%2C%20p.%20e0143972.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pone.0143972%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pone.0143972%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Responders%20to%20Wide-Pulse%2C%20High-Frequency%20Neuromuscular%20Electrical%20Stimulation%20Show%20Reduced%20Metabolic%20Demand%3A%20A%2031P-MRS%20Study%20in%20Humans%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jennifer%22%2C%22lastName%22%3A%22Wegrzyk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandre%22%2C%22lastName%22%3A%22Four%5Cu00e9%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yann%22%2C%22lastName%22%3A%22Le%20Fur%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicola%20A.%22%2C%22lastName%22%3A%22Maffiuletti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christophe%22%2C%22lastName%22%3A%22Vilmen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maxime%22%2C%22lastName%22%3A%22Guye%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Pierre%22%2C%22lastName%22%3A%22Mattei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Place%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Bendahan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julien%22%2C%22lastName%22%3A%22Gondin%22%7D%5D%2C%22abstractNote%22%3A%22Conventional%20%28CONV%29%20neuromuscular%20electrical%20stimulation%20%28NMES%29%20%28i.e.%2C%20short%20pulse%20duration%2C%20low%20frequencies%29%20induces%20a%20higher%20energetic%20response%20as%20compared%20to%20voluntary%20contractions%20%28VOL%29.%20In%20contrast%2C%20wide-pulse%2C%20high-frequency%20%28WPHF%29%20NMES%20might%20elicit-at%20least%20in%20some%20subjects%20%28i.e.%2C%20responders%29-a%20different%20motor%20unit%20recruitment%20compared%20to%20CONV%20that%20resembles%20the%20physiological%20muscle%20activation%20pattern%20of%20VOL.%20We%20therefore%20hypothesized%20that%20for%20these%20responder%20subjects%2C%20the%20metabolic%20demand%20of%20WPHF%20would%20be%20lower%20than%20CONV%20and%20comparable%20to%20VOL.%2018%20healthy%20subjects%20performed%20isometric%20plantar%20flexions%20at%2010%25%20of%20their%20maximal%20voluntary%20contraction%20force%20for%20CONV%20%2825%20Hz%2C%200.05%20ms%29%2C%20WPHF%20%28100%20Hz%2C%201%20ms%29%20and%20VOL%20protocols.%20For%20each%20protocol%2C%20force%20time%20integral%20%28FTI%29%20was%20quantified%20and%20subjects%20were%20classified%20as%20responders%20and%20non-responders%20to%20WPHF%20based%20on%20k-means%20clustering%20analysis.%20Furthermore%2C%20a%20fatigue%20index%20based%20on%20FTI%20loss%20at%20the%20end%20of%20each%20protocol%20compared%20with%20the%20beginning%20of%20the%20protocol%20was%20calculated.%20Phosphocreatine%20depletion%20%28%5Cu0394PCr%29%20was%20assessed%20using%2031P%20magnetic%20resonance%20spectroscopy.%20Responders%20developed%20four%20times%20higher%20FTI%26%23039%3Bs%20during%20WPHF%20%2899%20%5Cu00b1%2037%20%5Cu00d7103%20N.s%29%20than%20non-responders%20%2826%20%5Cu00b1%2012%20%5Cu00d7103%20N.s%29.%20For%20both%20responders%20and%20non-responders%2C%20CONV%20was%20metabolically%20more%20demanding%20than%20VOL%20when%20%5Cu0394PCr%20was%20expressed%20relative%20to%20the%20FTI.%20Only%20for%20the%20responder%20group%2C%20the%20%5Cu2206PCr%5C%2FFTI%20ratio%20of%20WPHF%20%280.74%20%5Cu00b1%200.19%20M%5C%2FN.s%29%20was%20significantly%20lower%20compared%20to%20CONV%20%281.48%20%5Cu00b1%200.46%20M%5C%2FN.s%29%20but%20similar%20to%20VOL%20%280.65%20%5Cu00b1%200.21%20M%5C%2FN.s%29.%20Moreover%2C%20the%20fatigue%20index%20was%20not%20different%20between%20WPHF%20%28-16%25%29%20and%20CONV%20%28-25%25%29%20for%20the%20responders.%20WPHF%20could%20therefore%20be%20considered%20as%20the%20less%20demanding%20NMES%20modality-at%20least%20in%20this%20subgroup%20of%20subjects-by%20possibly%20exhibiting%20a%20muscle%20activation%20pattern%20similar%20to%20VOL%20contractions.%22%2C%22date%22%3A%222015%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1371%5C%2Fjournal.pone.0143972%22%2C%22ISSN%22%3A%221932-6203%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22SVI8UJ6H%22%2C%226XQENTHJ%22%2C%227FK4UDH9%22%2C%22NW6SZQBR%22%2C%226M38MJ3E%22%2C%22SXWA9VN6%22%2C%22XTA6KS7L%22%5D%2C%22dateModified%22%3A%222024-12-13T09%3A12%3A43Z%22%7D%7D%2C%7B%22key%22%3A%22QMEVP5GJ%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Silvy%20et%20al.%22%2C%22parsedDate%22%3A%222015%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BSilvy%2C%20F.%2C%20Bertin%2C%20D.%2C%20Bardin%2C%20N.%2C%20Auger%2C%20I.%2C%20Guzian%2C%20M.-C.%2C%20Mattei%2C%20J.-P.%2C%20Guis%2C%20S.%2C%20Roudier%2C%20J.%20and%20Balandraud%2C%20N.%20%282015%29%20%26%23x201C%3BAntinuclear%20Antibodies%20in%20Patients%20with%20Psoriatic%20Arthritis%20Treated%20or%20Not%20with%20Biologics%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BPloS%20One%26lt%3B%5C%2Fi%26gt%3B%2C%2010%287%29%2C%20p.%20e0134218.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pone.0134218%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pone.0134218%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Antinuclear%20Antibodies%20in%20Patients%20with%20Psoriatic%20Arthritis%20Treated%20or%20Not%20with%20Biologics%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florent%22%2C%22lastName%22%3A%22Silvy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniel%22%2C%22lastName%22%3A%22Bertin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nathalie%22%2C%22lastName%22%3A%22Bardin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Isabelle%22%2C%22lastName%22%3A%22Auger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marie-Caroline%22%2C%22lastName%22%3A%22Guzian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Pierre%22%2C%22lastName%22%3A%22Mattei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sandrine%22%2C%22lastName%22%3A%22Guis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean%22%2C%22lastName%22%3A%22Roudier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nathalie%22%2C%22lastName%22%3A%22Balandraud%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20With%20the%20emergence%20of%20biotherapies%2C%20accurate%20diagnosis%20in%20early%20arthritis%20is%20needed.%20At%20this%20time%2C%20there%20is%20no%20biological%20marker%20of%20psoriatic%20arthritis.%5CnOBJECTIVE%3A%20To%20test%20whether%20antinuclear%20antibodies%20%28ANA%29%20can%20be%20used%20as%20a%20diagnostic%20tool%20in%20psoriatic%20arthritis%20%28PsA%29%2C%20we%20evaluated%20the%20prevalence%20of%20ANA%20in%20biologic-na%5Cu00efve%20PsA%20patients%20and%20in%20healthy%20blood%20donors.%5CnMETHODS%3A%20232%20patients%20from%20the%20Rheumatology%20department%2C%20St%20Marguerite%26%23039%3Bs%20Hospital%2C%20Marseilles%2C%20who%20fulfilled%20the%20CASPAR%20criteria%20for%20PsA%2C%20underwent%20clinical%20and%20laboratory%20investigations.%20Antinuclear%20antibodies%20%28ANA%29%2C%20anti-extractable%20nuclear%20antigen%20antibodies%20%28ENA%29%2C%20rheumatoid%20factor%20%28RF%29%2C%20anti-citrullinated%20protein%20antibodies%20%28ACPA%29%20were%20assayed.%20Ninety-one%20healthy%20blood%20donors%20were%20also%20tested.%5CnRESULTS%3A%20Detection%20of%20ANA%20by%20indirect%20immunofluorescence%20was%20significantly%20more%20frequent%20in%20sera%20from%20PsA%20patients%20than%20those%20from%20controls%20at%20serum%20dilution%20of%201%3A100%20%2857%25%20compared%20with%2040%25%2C%20Odds%20Ratio%20%28OR%29%201.98%20%281.2-3.4%29%20p%26lt%3B0.02%29%20and%201%3A160%20%2852%25%20compared%20with%2024%25%2C%20OR%203%2C7%20%281.9-7.2%29%20p%26lt%3B0.001%29.%20No%20patients%20had%20lupus%20specific%20autoantibodies%2C%2015%20%25%20had%20RF%20%2834%5C%2F232%29%2C%20and%201.7%20%25%20had%20ACPA%20%284%5C%2F232%29.%5CnCONCLUSIONS%3A%20Detection%20of%20ANA%20was%20more%20frequent%20in%20sera%20from%20PsA%20patients%20than%20in%20those%20from%20healthy%20controls.%20This%20suggests%20that%20ANA%20could%20be%20a%20diagnosis%20orientation%20tool%20in%20PsA.%20Nevertheless%2C%20the%20specificity%20of%20these%20antibodies%20still%20remains%20to%20be%20investigated.%22%2C%22date%22%3A%222015%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1371%5C%2Fjournal.pone.0134218%22%2C%22ISSN%22%3A%221932-6203%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%226BEMAGEW%22%5D%2C%22dateModified%22%3A%222024-10-29T10%3A45%3A37Z%22%7D%7D%2C%7B%22key%22%3A%229GIK2WWN%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Four%5Cu00e9%20et%20al.%22%2C%22parsedDate%22%3A%222015%22%2C%22numChildren%22%3A3%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BFour%26%23xE9%3B%2C%20A.%2C%20Le%20Troter%2C%20A.%2C%20Guye%2C%20M.%2C%20Mattei%2C%20J.-P.%2C%20Bendahan%2C%20D.%20and%20Gondin%2C%20J.%20%282015%29%20%26%23x201C%3BLocalization%20and%20quantification%20of%20intramuscular%20damage%20using%20statistical%20parametric%20mapping%20and%20skeletal%20muscle%20parcellation%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BScientific%20Reports%26lt%3B%5C%2Fi%26gt%3B%2C%205%2C%20p.%2018580.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fsrep18580%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fsrep18580%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Localization%20and%20quantification%20of%20intramuscular%20damage%20using%20statistical%20parametric%20mapping%20and%20skeletal%20muscle%20parcellation%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandre%22%2C%22lastName%22%3A%22Four%5Cu00e9%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Arnaud%22%2C%22lastName%22%3A%22Le%20Troter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maxime%22%2C%22lastName%22%3A%22Guye%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Pierre%22%2C%22lastName%22%3A%22Mattei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Bendahan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julien%22%2C%22lastName%22%3A%22Gondin%22%7D%5D%2C%22abstractNote%22%3A%22In%20the%20present%20study%2C%20we%20proposed%20an%20original%20and%20robust%20methodology%20which%20combines%20the%20spatial%20normalization%20of%20skeletal%20muscle%20images%2C%20the%20statistical%20parametric%20mapping%20%28SPM%29%20analysis%20and%20the%20use%20of%20a%20specific%20parcellation%20in%20order%20to%20accurately%20localize%20and%20quantify%20the%20extent%20of%20skeletal%20muscle%20damage%20within%20the%20four%20heads%20of%20the%20quadriceps%20femoris.%20T2%20maps%20of%20thigh%20muscles%20were%20characterized%20before%2C%20two%20%28D2%29%20and%20four%20%28D4%29%20days%20after%2040%20maximal%20isometric%20electrically-evoked%20contractions%20in%2025%20healthy%20young%20males.%20On%20the%20basis%20of%20SPM%20analysis%20of%20coregistrated%20T2%20maps%2C%20the%20alterations%20were%20similarly%20detected%20at%20D2%20and%20D4%20in%20the%20superficial%20and%20distal%20regions%20of%20the%20vastus%20medialis%20%28VM%29%20whereas%20the%20proportion%20of%20altered%20muscle%20was%20higher%20in%20deep%20muscle%20regions%20of%20the%20vastus%20lateralis%20at%20D4%20%28deep%3A%2035%5Cu2009%5Cu00b1%5Cu200925%25%2C%20superficial%3A%2023%5Cu2009%5Cu00b1%5Cu200915%25%29%20as%20compared%20to%20D2%20%28deep%3A%2018%5Cu2009%5Cu00b1%5Cu200913%25%2C%20superficial%3A%2017%5Cu2009%5Cu00b1%5Cu200913%25%29.%20The%20present%20methodology%20used%20for%20the%20first%20time%20on%20skeletal%20muscle%20would%20be%20of%20utmost%20interest%20to%20detect%20subtle%20intramuscular%20alterations%20not%20only%20for%20the%20diagnosis%20of%20muscular%20diseases%20but%20also%20for%20assessing%20the%20efficacy%20of%20potential%20therapeutic%20interventions%20and%20clinical%20treatment%20strategies.%22%2C%22date%22%3A%222015%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1038%5C%2Fsrep18580%22%2C%22ISSN%22%3A%222045-2322%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%226XQENTHJ%22%2C%22NW6SZQBR%22%2C%226M38MJ3E%22%2C%225P5FWCR9%22%2C%22XTA6KS7L%22%5D%2C%22dateModified%22%3A%222024-09-16T13%3A08%3A35Z%22%7D%7D%2C%7B%22key%22%3A%225JJ98QBA%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Four%5Cu00e9%20et%20al.%22%2C%22parsedDate%22%3A%222014%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BFour%26%23xE9%3B%2C%20A.%2C%20Nosaka%2C%20K.%2C%20Wegrzyk%2C%20J.%2C%20Duhamel%2C%20G.%2C%20Le%20Troter%2C%20A.%2C%20Boudinet%2C%20H.%2C%20Mattei%2C%20J.-P.%2C%20Vilmen%2C%20C.%2C%20Jubeau%2C%20M.%2C%20Bendahan%2C%20D.%20and%20Gondin%2C%20J.%20%282014%29%20%26%23x201C%3BTime%20course%20of%20central%20and%20peripheral%20alterations%20after%20isometric%20neuromuscular%20electrical%20stimulation-induced%20muscle%20damage%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BPloS%20One%26lt%3B%5C%2Fi%26gt%3B%2C%209%289%29%2C%20p.%20e107298.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pone.0107298%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pone.0107298%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Time%20course%20of%20central%20and%20peripheral%20alterations%20after%20isometric%20neuromuscular%20electrical%20stimulation-induced%20muscle%20damage%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandre%22%2C%22lastName%22%3A%22Four%5Cu00e9%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kazunori%22%2C%22lastName%22%3A%22Nosaka%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jennifer%22%2C%22lastName%22%3A%22Wegrzyk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guillaume%22%2C%22lastName%22%3A%22Duhamel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Arnaud%22%2C%22lastName%22%3A%22Le%20Troter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22H%5Cu00e9l%5Cu00e8ne%22%2C%22lastName%22%3A%22Boudinet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Pierre%22%2C%22lastName%22%3A%22Mattei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christophe%22%2C%22lastName%22%3A%22Vilmen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marc%22%2C%22lastName%22%3A%22Jubeau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Bendahan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julien%22%2C%22lastName%22%3A%22Gondin%22%7D%5D%2C%22abstractNote%22%3A%22Isometric%20contractions%20induced%20by%20neuromuscular%20electrostimulation%20%28NMES%29%20have%20been%20shown%20to%20result%20in%20a%20prolonged%20force%20decrease%20but%20the%20time%20course%20of%20the%20potential%20central%20and%20peripheral%20factors%20have%20never%20been%20investigated.%20This%20study%20examined%20the%20specific%20time%20course%20of%20central%20and%20peripheral%20factors%20after%20isometric%20NMES-induced%20muscle%20damage.%20Twenty-five%20young%20healthy%20men%20were%20subjected%20to%20an%20NMES%20exercise%20consisting%20of%2040%20contractions%20for%20both%20legs.%20Changes%20in%20maximal%20voluntary%20contraction%20force%20of%20the%20knee%20extensors%20%28MVC%29%2C%20peak%20evoked%20force%20during%20double%20stimulations%20at%2010%20Hz%20%28Db10%29%20and%20100%20Hz%20%28Db100%29%2C%20its%20ratio%20%2810%5Cu2236100%29%2C%20voluntary%20activation%2C%20muscle%20soreness%20and%20plasma%20creatine%20kinase%20activity%20were%20assessed%20before%2C%20immediately%20after%20and%20throughout%20four%20days%20after%20NMES%20session.%20Changes%20in%20knee%20extensors%20volume%20and%20T2%20relaxation%20time%20were%20also%20assessed%20at%20two%20%28D2%29%20and%20four%20%28D4%29%20days%20post-exercise.%20MVC%20decreased%20by%2029%25%20immediately%20after%20NMES%20session%20and%20was%20still%2019%25%20lower%20than%20the%20baseline%20value%20at%20D4.%20The%20decrease%20in%20Db10%20was%20higher%20than%20in%20Db100%20immediately%20and%20one%20day%20post-exercise%20resulting%20in%20a%20decrease%20%28-12%25%29%20in%20the%2010%5Cu2236100%20ratio.%20On%20the%20contrary%2C%20voluntary%20activation%20significantly%20decreased%20at%20D2%20%28-5%25%29%20and%20was%20still%20depressed%20at%20D4%20%28-5%25%29.%20Muscle%20soreness%20and%20plasma%20creatine%20kinase%20activity%20increased%20after%20NMES%20and%20peaked%20at%20D2%20and%20D4%2C%20respectively.%20T2%20was%20also%20increased%20at%20D2%20%286%25%29%20and%20D4%20%289%25%29.%20Additionally%2C%20changes%20in%20MVC%20and%20peripheral%20factors%20%28e.g.%2C%20Db100%29%20were%20correlated%20on%20the%20full%20recovery%20period%2C%20while%20a%20significant%20correlation%20was%20found%20between%20changes%20in%20MVC%20and%20VA%20only%20from%20D2%20to%20D4.%20The%20decrease%20in%20MVC%20recorded%20immediately%20after%20the%20NMES%20session%20was%20mainly%20due%20to%20peripheral%20changes%20while%20both%20central%20and%20peripheral%20contributions%20were%20involved%20in%20the%20prolonged%20force%20reduction.%20Interestingly%2C%20the%20chronological%20events%20differ%20from%20what%20has%20been%20reported%20so%20far%20for%20voluntary%20exercise-induced%20muscle%20damage.%22%2C%22date%22%3A%222014%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1371%5C%2Fjournal.pone.0107298%22%2C%22ISSN%22%3A%221932-6203%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%224U7D3E9U%22%2C%226XQENTHJ%22%2C%227FK4UDH9%22%2C%22NW6SZQBR%22%2C%226M38MJ3E%22%2C%22SXWA9VN6%22%2C%225P5FWCR9%22%5D%2C%22dateModified%22%3A%222024-12-13T09%3A12%3A42Z%22%7D%7D%2C%7B%22key%22%3A%2279MKR4XC%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Zink%20et%20al.%22%2C%22parsedDate%22%3A%222013-06%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BZink%2C%20J.%2C%20Souteyrand%2C%20P.%2C%20Guis%2C%20S.%2C%20Chagnaud%2C%20C.%2C%20Le%20Fur%2C%20Y.%2C%20Militianu%2C%20D.%2C%20Mattei%2C%20J.P.%2C%20Rozenbaum%2C%20M.%2C%20Rosner%2C%20I.%2C%20Boudinet%2C%20H.%2C%20Bernard%2C%20M.%20and%20Bendahan%2C%20D.%20%282013%29%20%26%23x201C%3BSemi-Automatic%20Quantitative%20Investigation%20of%20Wrist%20Cartilage%20in%20Humans%20Using%203t%20Mri%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BAnnals%20of%20the%20Rheumatic%20Diseases%26lt%3B%5C%2Fi%26gt%3B%2C%2072%2C%20pp.%201018%26%23x2013%3B1019.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Semi-Automatic%20Quantitative%20Investigation%20of%20Wrist%20Cartilage%20in%20Humans%20Using%203t%20Mri%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Zink%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P.%22%2C%22lastName%22%3A%22Souteyrand%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Guis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%22%2C%22lastName%22%3A%22Chagnaud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Y.%22%2C%22lastName%22%3A%22Le%20Fur%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D.%22%2C%22lastName%22%3A%22Militianu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%20P.%22%2C%22lastName%22%3A%22Mattei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Rozenbaum%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22I.%22%2C%22lastName%22%3A%22Rosner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22H.%22%2C%22lastName%22%3A%22Boudinet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Bernard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D.%22%2C%22lastName%22%3A%22Bendahan%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%22JUN%202013%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%22%22%2C%22ISSN%22%3A%220003-4967%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22SVI8UJ6H%22%2C%225Z6CVJGB%22%2C%22NW6SZQBR%22%2C%226BEMAGEW%22%5D%2C%22dateModified%22%3A%222014-12-19T08%3A25%3A57Z%22%7D%7D%2C%7B%22key%22%3A%22IURAQW99%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22lastModifiedByUser%22%3A%7B%22id%22%3A1497928%2C%22username%22%3A%22fkober%22%2C%22name%22%3A%22Frank%20Kober%22%2C%22links%22%3A%7B%22alternate%22%3A%7B%22href%22%3A%22https%3A%5C%2F%5C%2Fwww.zotero.org%5C%2Ffkober%22%2C%22type%22%3A%22text%5C%2Fhtml%22%7D%7D%7D%2C%22creatorSummary%22%3A%22Guis%20et%20al.%22%2C%22parsedDate%22%3A%222013-05%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BGuis%2C%20S.%2C%20Mattei%2C%20J.-P.%20and%20Bendahan%2C%20D.%20%282013%29%20%26%23x201C%3BToxic%20myopathies%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BJoint%2C%20bone%2C%20spine%3A%20revue%20du%20rhumatisme%26lt%3B%5C%2Fi%26gt%3B%2C%2080%283%29%2C%20pp.%20231%26%23x2013%3B233.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jbspin.2012.10.008%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jbspin.2012.10.008%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Toxic%20myopathies%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sandrine%22%2C%22lastName%22%3A%22Guis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Pierre%22%2C%22lastName%22%3A%22Mattei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Bendahan%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%22May%202013%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.jbspin.2012.10.008%22%2C%22ISSN%22%3A%221778-7254%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22NW6SZQBR%22%2C%226BEMAGEW%22%5D%2C%22dateModified%22%3A%222024-10-29T10%3A45%3A28Z%22%7D%7D%2C%7B%22key%22%3A%22ESP2GJ93%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Cammilleri%20et%20al.%22%2C%22parsedDate%22%3A%222013%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BCammilleri%2C%20S.%2C%20Guzian%2C%20M.C.%2C%20Mattei%2C%20J.-P.%2C%20Mundler%2C%20O.%20and%20Guis%2C%20S.%20%282013%29%20%26%23x201C%3BWhole-Body%20%2818%29%20FDG-PET%20in%20an%20Arthritis%20Paraneoplastic%20Syndrome%20Revealed%20an%20Underlying%20Hematological%20Neoplasm%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BCase%20Reports%20in%20Medicine%26lt%3B%5C%2Fi%26gt%3B%2C%202013%2C%20p.%20594704.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1155%5C%2F2013%5C%2F594704%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1155%5C%2F2013%5C%2F594704%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Whole-Body%20%2818%29%20FDG-PET%20in%20an%20Arthritis%20Paraneoplastic%20Syndrome%20Revealed%20an%20Underlying%20Hematological%20Neoplasm%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Serge%22%2C%22lastName%22%3A%22Cammilleri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marie%20Caroline%22%2C%22lastName%22%3A%22Guzian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Pierre%22%2C%22lastName%22%3A%22Mattei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Olivier%22%2C%22lastName%22%3A%22Mundler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sandrine%22%2C%22lastName%22%3A%22Guis%22%7D%5D%2C%22abstractNote%22%3A%22We%20showed%20the%20first%20image%20of%20%2818%29FDG-PET%2C%20which%20leads%20to%20a%20diagnosis%20of%20lymphoma%20in%20an%20atypical%20polyarthritis.%20About%204%25%20of%20patients%20with%20lymphoma%20or%20leukemia%20suffered%20from%20rheumatologic%20paraneoplastic%20symptoms%20like%20arthralgia%20and%20about%2010%25%20of%20the%20patients%20with%20rheumatologic%20or%20neurologic%20clinical%20symptoms%20develop%20a%20solid%20cancer%20or%20hematological%20neoplasm.%20%2818%29FDG-PET%20is%20an%20interesting%20exam%20to%20identify%20an%20underlying%20malignancy%20when%20a%20paraneoplastic%20syndrome%20is%20suspected%3B%20it%20can%20detect%20the%20primitive%20lesion%20and%5C%2For%20the%20metastasis%20lesions.%20The%20use%20of%20the%20%2818%29FDG-PET%20can%20help%20to%20detect%20earlier%20hematological%20neoplasm%20in%20cases%20of%20paraneoplastic%20syndrome%20without%20a%20determined%20cause%20and%20to%20treat%20more%20rapidly%20and%20specifically%20the%20patient.%22%2C%22date%22%3A%222013%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1155%5C%2F2013%5C%2F594704%22%2C%22ISSN%22%3A%221687-9627%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%226BEMAGEW%22%5D%2C%22dateModified%22%3A%222015-09-04T09%3A15%3A00Z%22%7D%7D%2C%7B%22key%22%3A%225FGGIEIK%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Guis%20et%20al.%22%2C%22parsedDate%22%3A%222008-08%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BGuis%2C%20S.%2C%20Schiano%20de%20Colella%2C%20J.-M.%2C%20Bonnet%2C%20N.%2C%20Andrac-Meyer%2C%20L.%2C%20Balandraud%2C%20N.%2C%20Mattei%2C%20J.-P.%2C%20Franck%2C%20B.%2C%20Roudier%2C%20C.%2C%20Roudier%2C%20J.%20and%20Berbis%2C%20P.%20%282008%29%20%26%23x201C%3BCutaneous%20pseudolymphoma%20associated%20with%20a%20TNF-alpha%20inhibitor%20treatment%3A%20etanercept%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BEuropean%20journal%20of%20dermatology%3A%20EJD%26lt%3B%5C%2Fi%26gt%3B%2C%2018%284%29%2C%20pp.%20474%26%23x2013%3B476.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1684%5C%2Fejd.2008.0457%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1684%5C%2Fejd.2008.0457%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Cutaneous%20pseudolymphoma%20associated%20with%20a%20TNF-alpha%20inhibitor%20treatment%3A%20etanercept%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sandrine%22%2C%22lastName%22%3A%22Guis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Marc%22%2C%22lastName%22%3A%22Schiano%20de%20Colella%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nathalie%22%2C%22lastName%22%3A%22Bonnet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lucille%22%2C%22lastName%22%3A%22Andrac-Meyer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nathalie%22%2C%22lastName%22%3A%22Balandraud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Pierre%22%2C%22lastName%22%3A%22Mattei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bernard%22%2C%22lastName%22%3A%22Franck%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chantal%22%2C%22lastName%22%3A%22Roudier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean%22%2C%22lastName%22%3A%22Roudier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Phillippe%22%2C%22lastName%22%3A%22Berbis%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222008%20Jul-Aug%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1684%5C%2Fejd.2008.0457%22%2C%22ISSN%22%3A%221167-1122%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%225Z6CVJGB%22%2C%226BEMAGEW%22%5D%2C%22dateModified%22%3A%222015-09-04T09%3A15%3A00Z%22%7D%7D%2C%7B%22key%22%3A%223NXSWBP9%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Guis%20et%20al.%22%2C%22parsedDate%22%3A%222007-12-15%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BGuis%2C%20S.%2C%20Balandraud%2C%20N.%2C%20Bouvenot%2C%20J.%2C%20Auger%2C%20I.%2C%20Toussirot%2C%20E.%2C%20Wendling%2C%20D.%2C%20Mattei%2C%20J.-P.%2C%20Nogueira%2C%20L.%2C%20Mugnier%2C%20B.%2C%20Legeron%2C%20P.%2C%20Landt%2C%20O.%2C%20Serre%2C%20G.%2C%20Roudier%2C%20J.%20and%20Roudier%2C%20C.%20%282007%29%20%26%23x201C%3BInfluence%20of%20-308%20A%5C%2FG%20polymorphism%20in%20the%20tumor%20necrosis%20factor%20alpha%20gene%20on%20etanercept%20treatment%20in%20rheumatoid%20arthritis%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BArthritis%20and%20Rheumatism%26lt%3B%5C%2Fi%26gt%3B%2C%2057%288%29%2C%20pp.%201426%26%23x2013%3B1430.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fart.23092%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fart.23092%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Influence%20of%20-308%20A%5C%2FG%20polymorphism%20in%20the%20tumor%20necrosis%20factor%20alpha%20gene%20on%20etanercept%20treatment%20in%20rheumatoid%20arthritis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sandrine%22%2C%22lastName%22%3A%22Guis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nathalie%22%2C%22lastName%22%3A%22Balandraud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julien%22%2C%22lastName%22%3A%22Bouvenot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Isabelle%22%2C%22lastName%22%3A%22Auger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%22%2C%22lastName%22%3A%22Toussirot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniel%22%2C%22lastName%22%3A%22Wendling%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Pierre%22%2C%22lastName%22%3A%22Mattei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leonor%22%2C%22lastName%22%3A%22Nogueira%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benedicte%22%2C%22lastName%22%3A%22Mugnier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pierre%22%2C%22lastName%22%3A%22Legeron%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Olfert%22%2C%22lastName%22%3A%22Landt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guy%22%2C%22lastName%22%3A%22Serre%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean%22%2C%22lastName%22%3A%22Roudier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chantal%22%2C%22lastName%22%3A%22Roudier%22%7D%5D%2C%22abstractNote%22%3A%22OBJECTIVE%3A%20To%20determine%20whether%20the%20-308%20A%5C%2FG%20tumor%20necrosis%20factor%20alpha%20%28TNFalpha%29%20gene%20polymorphism%20can%20predict%20the%20outcome%20of%20etanercept%20therapy%20in%2086%20patients%20with%20rheumatoid%20arthritis%20%28RA%29%2C%20as%20already%20observed%20in%20patients%20treated%20with%20infliximab.%5CnMETHODS%3A%20Eighty-six%20RA%20patients%20treated%20with%20etanercept%20were%20genotyped%20for%20-308%20A%5C%2FG%20TNFalpha%20gene%20polymorphism%20by%20polymerase%20chain%20reaction%20and%20melting%20curve%20analysis%2C%20using%20specific%20gene%20primers%20and%20probes.%20Patients%20were%20subdivided%20into%20group%20A%20%28G%5C%2FA%20genotype%29%20and%20group%20G%20%28G%5C%2FG%20genotype%29.%20We%20compared%20clinical%20responses%20to%20etanercept%20between%20groups%20A%20and%20G%20after%206%20months%2C%20using%20the%20Disease%20Activity%20Score%20in%2028%20joints%20%28DAS28%29.%20After%2012-month%20treatment%2C%2048%20of%2086%20patients%20were%20evaluated%20again.%5CnRESULTS%3A%20Of%2086%20patients%2C%2018%20%2821%25%29%20belonged%20in%20group%20A%20and%2068%20%2879%25%29%20belonged%20in%20group%20G.%20After%206-month%20treatment%2C%2055.6%25%20of%20patients%20in%20group%20A%20and%2082.4%25%20of%20patients%20in%20group%20G%20had%20DAS28%20improvement%20%26gt%3B1.2%20%28P%20%3D%200.027%20by%20chi-square%29.%20The%20mean%20%2B%5C%2F-%20SD%20DAS28%20improvement%20was%201.69%20%2B%5C%2F-%201.31%20in%20group%20A%20and%202.23%20%2B%5C%2F-%201.19%20in%20group%20G%20%28P%20%3D%200.098%20by%20t-test%29.%20After%201-year%20treatment%2048%20patients%20were%20tested%20again%3A%2010%20%2821%25%29%20belonged%20in%20group%20A%20and%2038%20%2879%25%29%20belonged%20in%20group%20G.%20Forty%20percent%20of%20patients%20in%20group%20A%20and%2087%25%20in%20group%20G%20had%20DAS28%20improvement%20%26gt%3B1.2%20%28P%20%3D%200.005%20by%20chi-square%29.%20The%20mean%20%2B%5C%2F-%20SD%20DAS28%20improvement%20was%201.334%20%2B%5C%2F-%201.37%20in%20group%20A%20and%202.29%20%2B%5C%2F-%201.47%20in%20group%20G%20%28Mann-Whitney%20U%20test%20%3D%20115%2C%20P%20%3D%200.0057%29.%5CnCONCLUSION%3A%20RA%20patients%20with%20a%20-308%20G%5C%2FG%20TNFalpha%20genotype%20respond%20to%20etanercept%20better%20than%20patients%20with%20a%20-308%20A%5C%2FG%20genotype.%22%2C%22date%22%3A%22Dec%2015%2C%202007%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1002%5C%2Fart.23092%22%2C%22ISSN%22%3A%220004-3591%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%226BEMAGEW%22%5D%2C%22dateModified%22%3A%222024-10-29T10%3A45%3A23Z%22%7D%7D%2C%7B%22key%22%3A%227KMSB7IG%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Charpin%20et%20al.%22%2C%22parsedDate%22%3A%222007-05%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BCharpin%2C%20C.%2C%20Berbis%2C%20P.%2C%20Schmitz%2C%20J.%2C%20Boudinet%2C%20H.%2C%20Mattei%2C%20J.-P.%2C%20Balandraud%2C%20N.%2C%20Chagnaud%2C%20C.%2C%20Roudier%2C%20J.%20and%20Guis%2C%20S.%20%282007%29%20%26%23x201C%3BNeurofibromatosis%20type%201%20with%20sciatica%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BJoint%2C%20Bone%2C%20Spine%3A%20Revue%20Du%20Rhumatisme%26lt%3B%5C%2Fi%26gt%3B%2C%2074%283%29%2C%20pp.%20300%26%23x2013%3B301.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jbspin.2006.09.013%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jbspin.2006.09.013%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Neurofibromatosis%20type%201%20with%20sciatica%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Caroline%22%2C%22lastName%22%3A%22Charpin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philippe%22%2C%22lastName%22%3A%22Berbis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00e9rome%22%2C%22lastName%22%3A%22Schmitz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22H%5Cu00e9l%5Cu00e8ne%22%2C%22lastName%22%3A%22Boudinet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Pierre%22%2C%22lastName%22%3A%22Mattei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nathalie%22%2C%22lastName%22%3A%22Balandraud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christophe%22%2C%22lastName%22%3A%22Chagnaud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean%22%2C%22lastName%22%3A%22Roudier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sandrine%22%2C%22lastName%22%3A%22Guis%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%22May%202007%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.jbspin.2006.09.013%22%2C%22ISSN%22%3A%221778-7254%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%226BEMAGEW%22%5D%2C%22dateModified%22%3A%222015-09-04T09%3A15%3A00Z%22%7D%7D%2C%7B%22key%22%3A%22QR3NGWRX%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22lastModifiedByUser%22%3A%7B%22id%22%3A1497928%2C%22username%22%3A%22fkober%22%2C%22name%22%3A%22Frank%20Kober%22%2C%22links%22%3A%7B%22alternate%22%3A%7B%22href%22%3A%22https%3A%5C%2F%5C%2Fwww.zotero.org%5C%2Ffkober%22%2C%22type%22%3A%22text%5C%2Fhtml%22%7D%7D%7D%2C%22creatorSummary%22%3A%22Mattei%20et%20al.%22%2C%22parsedDate%22%3A%222006-11%22%2C%22numChildren%22%3A3%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BMattei%2C%20J.P.%2C%20Fur%2C%20Y.L.%2C%20Cuge%2C%20N.%2C%20Guis%2C%20S.%2C%20Cozzone%2C%20P.J.%20and%20Bendahan%2C%20D.%20%282006%29%20%26%23x201C%3BSegmentation%20of%20fascias%2C%20fat%20and%20muscle%20from%20magnetic%20resonance%20images%20in%20humans%3A%20the%20DISPIMAG%20software%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BMagma%20%28New%20York%2C%20N.Y.%29%26lt%3B%5C%2Fi%26gt%3B%2C%2019%285%29%2C%20pp.%20275%26%23x2013%3B279.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs10334-006-0051-1%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs10334-006-0051-1%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Segmentation%20of%20fascias%2C%20fat%20and%20muscle%20from%20magnetic%20resonance%20images%20in%20humans%3A%20the%20DISPIMAG%20software%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%20P%22%2C%22lastName%22%3A%22Mattei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Y%20Le%22%2C%22lastName%22%3A%22Fur%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N%22%2C%22lastName%22%3A%22Cuge%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S%22%2C%22lastName%22%3A%22Guis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P%20J%22%2C%22lastName%22%3A%22Cozzone%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D%22%2C%22lastName%22%3A%22Bendahan%22%7D%5D%2C%22abstractNote%22%3A%22Segmentation%20of%20human%20limb%20MR%20images%20into%20muscle%2C%20fat%20and%20fascias%20remains%20a%20cumbersome%20task.%20We%20have%20developed%20a%20new%20software%20%28DISPIMAG%29%20that%20allows%20automatic%20and%20highly%20reproducible%20segmentation%20of%20lower-limb%20MR%20images.%20Based%20on%20a%20pixel%20intensity%20analysis%2C%20this%20software%20does%20not%20need%20any%20previous%20mathematical%20or%20statistical%20assumptions.%20It%20displays%20a%20histogram%20with%20two%20main%20signals%20corresponding%20to%20fat%20and%20muscle%2C%20and%20permits%20an%20accurate%20quantification%20of%20their%20relative%20spatial%20distribution.%20To%20allow%20a%20systematic%20discrimination%20between%20muscle%20and%20fat%20in%20any%20subject%2C%20fixed%20boundaries%20were%20first%20determined%20manually%20in%20a%20group%20of%2024%20patients.%20Secondly%2C%20an%20entirely%20automatic%20process%20using%20these%20boundaries%20was%20tested%20by%20three%20operators%20on%20four%20patients%20and%20compared%20to%20the%20manual%20approach%2C%20showing%20a%20high%20concordance.%22%2C%22date%22%3A%22Nov%202006%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1007%5C%2Fs10334-006-0051-1%22%2C%22ISSN%22%3A%220968-5243%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22SVI8UJ6H%22%2C%22NW6SZQBR%22%2C%224ZGX55W3%22%2C%226BEMAGEW%22%5D%2C%22dateModified%22%3A%222023-05-15T08%3A59%3A45Z%22%7D%7D%2C%7B%22key%22%3A%22V7NZTIR4%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22lastModifiedByUser%22%3A%7B%22id%22%3A1497928%2C%22username%22%3A%22fkober%22%2C%22name%22%3A%22Frank%20Kober%22%2C%22links%22%3A%7B%22alternate%22%3A%7B%22href%22%3A%22https%3A%5C%2F%5C%2Fwww.zotero.org%5C%2Ffkober%22%2C%22type%22%3A%22text%5C%2Fhtml%22%7D%7D%7D%2C%22creatorSummary%22%3A%22Guis%20et%20al.%22%2C%22parsedDate%22%3A%222006-08-15%22%2C%22numChildren%22%3A3%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BGuis%2C%20S.%2C%20Figarella-Branger%2C%20D.%2C%20Mattei%2C%20J.P.%2C%20Nicoli%2C%20F.%2C%20Le%20Fur%2C%20Y.%2C%20Kozak-Ribbens%2C%20G.%2C%20Pellissier%2C%20J.F.%2C%20Cozzone%2C%20P.J.%2C%20Amabile%2C%20N.%20and%20Bendahan%2C%20D.%20%282006%29%20%26%23x201C%3BIn%20vivo%20and%20in%20vitro%20characterization%20of%20skeletal%20muscle%20metabolism%20in%20patients%20with%20statin-induced%20adverse%20effects%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BArthritis%20and%20rheumatism%26lt%3B%5C%2Fi%26gt%3B%2C%2055%284%29%2C%20pp.%20551%26%23x2013%3B557.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fart.22100%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fart.22100%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22In%20vivo%20and%20in%20vitro%20characterization%20of%20skeletal%20muscle%20metabolism%20in%20patients%20with%20statin-induced%20adverse%20effects%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S%22%2C%22lastName%22%3A%22Guis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D%22%2C%22lastName%22%3A%22Figarella-Branger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%20P%22%2C%22lastName%22%3A%22Mattei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22F%22%2C%22lastName%22%3A%22Nicoli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Y%22%2C%22lastName%22%3A%22Le%20Fur%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G%22%2C%22lastName%22%3A%22Kozak-Ribbens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%20F%22%2C%22lastName%22%3A%22Pellissier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P%20J%22%2C%22lastName%22%3A%22Cozzone%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N%22%2C%22lastName%22%3A%22Amabile%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D%22%2C%22lastName%22%3A%22Bendahan%22%7D%5D%2C%22abstractNote%22%3A%22OBJECTIVE%3A%20Statins%20%283-hydroxymethylglutaryl-coenzyme%20A%20reductase%20inhibitor%29%20are%20widely%20used%20to%20treat%20hypercholesterolemia.%20They%20are%20generally%20well%20tolerated%2C%20but%20myotoxic%20effects%20have%20been%20reported%20and%20the%20corresponding%20mechanisms%20are%20still%20a%20matter%20of%20debate.%20The%20aim%20of%20the%20present%20study%20was%20to%20determine%20whether%20impairment%20of%20calcium%20homeostasis%20and%5C%2For%20mitochondrial%20impairment%20could%20account%20for%20the%20adverse%20effects%20of%20statins%20in%20skeletal%20muscle.%5CnMETHODS%3A%20Eleven%20patients%20with%20increased%20creatine%20kinase%20levels%20and%20myalgias%20after%20statin%20treatment%20were%20evaluated%20using%20in%20vitro%20contracture%20tests%20%28IVCTs%29%2C%20histology%2C%20and%2031P%20magnetic%20resonance%20spectroscopy%20%2831P-MRS%29.%5CnRESULTS%3A%20IVCT%20results%20were%20abnormal%20in%207%20of%20the%209%20patients%2C%20indicating%20an%20impaired%20calcium%20homeostasis.%20The%2031P-MRS%20investigation%20disclosed%20no%20anomaly%20at%20rest%2C%20and%20the%20aerobic%20function%20assessed%20during%20the%20postexercise%20recovery%20period%20was%20normal.%20On%20the%20contrary%2C%20the%20pH%20recovery%20kinetics%20was%20significantly%20slowed%20down%20as%20indicated%20by%20a%20reduced%20proton%20efflux%2C%20which%20could%20be%20ultimately%20linked%20to%20a%20failure%20of%20calcium%20homeostasis.%20Overall%2C%20our%20observations%20indicate%20a%20normal%20mitochondrial%20function%20and%20raise%20the%20possibility%20that%20statins%20may%20unmask%20a%20latent%20pathology%20involving%20an%20impairment%20of%20calcium%20homeostasis%20such%20as%20malignant%20hyperthermia%20%28MH%29.%5CnCONCLUSION%3A%20In%20case%20of%20susceptibility%20to%20MH%2C%20statins%20treatment%20must%20be%20administered%20with%20caution%2C%20and%20signs%20of%20adverse%20effects%20should%20be%20checked.%22%2C%22date%22%3A%22Aug%2015%2C%202006%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1002%5C%2Fart.22100%22%2C%22ISSN%22%3A%220004-3591%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22SVI8UJ6H%22%2C%22NW6SZQBR%22%2C%224ZGX55W3%22%2C%226BEMAGEW%22%5D%2C%22dateModified%22%3A%222015-09-04T09%3A16%3A12Z%22%7D%7D%2C%7B%22key%22%3A%22BC8D887Q%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22lastModifiedByUser%22%3A%7B%22id%22%3A1497928%2C%22username%22%3A%22fkober%22%2C%22name%22%3A%22Frank%20Kober%22%2C%22links%22%3A%7B%22alternate%22%3A%7B%22href%22%3A%22https%3A%5C%2F%5C%2Fwww.zotero.org%5C%2Ffkober%22%2C%22type%22%3A%22text%5C%2Fhtml%22%7D%7D%7D%2C%22creatorSummary%22%3A%22Bendahan%20et%20al.%22%2C%22parsedDate%22%3A%222006-04%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BBendahan%2C%20D.%2C%20Mattei%2C%20J.P.%2C%20Guis%2C%20S.%2C%20Kozak-Ribbens%2C%20G.%20and%20Cozzone%2C%20P.J.%20%282006%29%20%26%23x201C%3B%5BNon-invasive%20investigation%20of%20muscle%20function%20using%2031P%20magnetic%20resonance%20spectroscopy%20and%201H%20MR%20imaging%5D%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BRevue%20neurologique%26lt%3B%5C%2Fi%26gt%3B%2C%20162%284%29%2C%20pp.%20467%26%23x2013%3B484.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22%5BNon-invasive%20investigation%20of%20muscle%20function%20using%2031P%20magnetic%20resonance%20spectroscopy%20and%201H%20MR%20imaging%5D%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D%22%2C%22lastName%22%3A%22Bendahan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%20P%22%2C%22lastName%22%3A%22Mattei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S%22%2C%22lastName%22%3A%22Guis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G%22%2C%22lastName%22%3A%22Kozak-Ribbens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P%20J%22%2C%22lastName%22%3A%22Cozzone%22%7D%5D%2C%22abstractNote%22%3A%2231P%20MRS%20and%201H%20MRI%20of%20skeletal%20muscle%20have%20become%20major%20new%20tools%20allowing%20a%20complete%20non%20invasive%20investigation%20of%20muscle%20function%20both%20in%20the%20clinical%20setting%20and%20in%20basic%20research.%20The%20comparative%20analysis%20of%20normal%20and%20diseased%20muscle%20remains%20a%20major%20requirement%20to%20further%20define%20metabolic%20events%20surrounding%20muscle%20contraction%20and%20the%20metabolic%20anomalies%20underlying%20pathologies.%20Also%2C%20standardized%20rest-exercise-recovery%20protocols%20for%20the%20exploration%20of%20muscle%20metabolism%20by%20P-31%20MRS%20in%20healthy%20volunteers%20as%20well%20as%20in%20patients%20with%20intolerance%20to%20exercise%20have%20been%20developed.%20The%20CRMBM%20protocol%20is%20based%20on%20a%20short-term%20intense%20exercise%2C%20which%20is%20very%20informative%20and%20well%20accepted%20by%20volunteers%20and%20patients.%20Invariant%20metabolic%20parameters%20have%20been%20defined%20to%20characterize%20the%20normal%20metabolic%20response%20to%20the%20protocol.%20Deviations%20from%20normality%20can%20be%20directly%20interpreted%20in%20terms%20of%20specific%20pathologies%20in%20some%20favorable%20cases.%20This%20protocol%20has%20been%20applied%20to%20more%20than%204%2C000%20patients%20and%20healthy%20volunteers%20over%20a%20period%20of%2015%20years.%20On%20the%20other%20hand%2C%20MRI%20investigations%20provide%20anatomical%20and%20functional%20information%20from%20resting%20and%20exercising%20muscle.%20From%20a%20diagnostic%20point%20of%20view%2C%20dedicated%20pulse%20sequences%20can%20be%20used%20in%20order%20to%20detect%20and%20quantify%20muscle%20inflammation%2C%20fatty%20replacement%2C%20muscle%20hyper%20and%20hypotrophy.%20In%20most%20cases%2C%20MR%20techniques%20provide%20valuable%20information%20which%20has%20to%20be%20processed%20in%20conjunction%20with%20traditional%20invasive%20biochemical%2C%20electrophysiological%20and%20histoenzymological%20tests.%20P-31%20MRS%20has%20proved%20particularly%20useful%20in%20the%20therapeutic%20follow-up%20of%20palliative%20therapies%20%28coenzyme%20Q%20treatment%20of%20mitochondriopathies%29%20and%20in%20family%20investigations.%20It%20is%20now%20an%20accepted%20diagnostic%20tool%20in%20the%20array%20of%20tests%20which%20are%20used%20to%20characterize%20muscle%20disorders%20in%20clinical%20routine.%20As%20a%20research%20tool%2C%20it%20will%20keep%20bringing%20new%20information%20on%20the%20physiopathology%20of%20muscle%20diseases%20in%20animal%20models%20and%20in%20humans%20and%20should%20play%20a%20role%20in%20the%20metabolic%20characterization%20of%20gene%20and%20cell%20therapy.%22%2C%22date%22%3A%22Apr%202006%22%2C%22language%22%3A%22fre%22%2C%22DOI%22%3A%22%22%2C%22ISSN%22%3A%220035-3787%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22NW6SZQBR%22%2C%224ZGX55W3%22%2C%226BEMAGEW%22%5D%2C%22dateModified%22%3A%222015-09-04T09%3A16%3A14Z%22%7D%7D%2C%7B%22key%22%3A%2242FDA2H4%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Alcaraz%20et%20al.%22%2C%22parsedDate%22%3A%222006-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BAlcaraz%2C%20P.%2C%20Aubran%2C%20C.%2C%20Jaoua%2C%20S.%2C%20Roudier%2C%20C.%2C%20Mattei%2C%20J.P.%2C%20Announ%2C%20N.%2C%20Chagnaud%2C%20C.%2C%20Roudier%2C%20J.%20and%20Guis%2C%20S.%20%282006%29%20%26%23x201C%3BCalcaneal%20osteomyelitis%20due%20to%20fistulization%20of%20an%20ulcerated%20rheumatoid%20nodule%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BJoint%2C%20Bone%2C%20Spine%3A%20Revue%20Du%20Rhumatisme%26lt%3B%5C%2Fi%26gt%3B%2C%2073%281%29%2C%20pp.%20102%26%23x2013%3B104.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jbspin.2005.01.006%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jbspin.2005.01.006%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Calcaneal%20osteomyelitis%20due%20to%20fistulization%20of%20an%20ulcerated%20rheumatoid%20nodule%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Patrice%22%2C%22lastName%22%3A%22Alcaraz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cl%5Cu00e9mence%22%2C%22lastName%22%3A%22Aubran%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sami%22%2C%22lastName%22%3A%22Jaoua%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chantal%22%2C%22lastName%22%3A%22Roudier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean%20Pierre%22%2C%22lastName%22%3A%22Mattei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadia%22%2C%22lastName%22%3A%22Announ%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christophe%22%2C%22lastName%22%3A%22Chagnaud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean%22%2C%22lastName%22%3A%22Roudier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sandrine%22%2C%22lastName%22%3A%22Guis%22%7D%5D%2C%22abstractNote%22%3A%22Calcaneal%20osteomyelitis%20is%20uncommon%20and%20difficult%20to%20treat.%20Cases%20due%20to%20fistulization%20of%20an%20infected%20rheumatoid%20nodule%20are%20exceedingly%20rare.%5CnPATIENT%3A%20A%2065-year-old%20patient%20with%20nodular%20rheumatoid%20arthritis%20%28RA%29%20experienced%20osteomyelitis%20of%20the%20left%20calcaneus%20due%20to%20inoculation%20from%20a%20fistula%20draining%20an%20ulcerated%20rheumatoid%20nodule.%20Pseudomonas%20aeruginosa%20and%20Enterobacter%20cloacae%20were%20recovered.%20The%20conventional%20treatment%20of%20calcaneal%20osteomyelitis%20relies%20on%20antibiotics%20and%20calcanectomy%20or%20foot%20amputation.%20We%20used%20two%20appropriate%20antibiotics%20and%20monthly%20intravenous%20injections%20of%2090%20mg%20of%20pamidronate.%5CnRESULT%3A%20One%20year%20into%20treatment%2C%20the%20patient%20was%20free%20of%20pain%20and%20the%20skin%20wound%20was%20fully%20healed.%20On%20a%20follow-up%20computed%20tomography%20%28CT%29%20scan%2C%20the%20fistulous%20tract%20was%20seen%20to%20be%20closed%20and%20the%20large%20calcaneal%20defect%20almost%20completely%20filled%20with%20new%20bone.%5CnCONCLUSION%3A%20Combining%20two%20antibiotics%20and%20pamidronate%20may%20be%20a%20viable%20alternative%20to%20excision%20surgery%20or%20amputation%20in%20some%20patients%20with%20bone%20infection%20carrying%20a%20risk%20of%20fracture.%22%2C%22date%22%3A%22Jan%202006%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.jbspin.2005.01.006%22%2C%22ISSN%22%3A%221297-319X%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%226BEMAGEW%22%5D%2C%22dateModified%22%3A%222015-09-04T09%3A15%3A23Z%22%7D%7D%2C%7B%22key%22%3A%22DUG4Z69R%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22lastModifiedByUser%22%3A%7B%22id%22%3A1497928%2C%22username%22%3A%22fkober%22%2C%22name%22%3A%22Frank%20Kober%22%2C%22links%22%3A%7B%22alternate%22%3A%7B%22href%22%3A%22https%3A%5C%2F%5C%2Fwww.zotero.org%5C%2Ffkober%22%2C%22type%22%3A%22text%5C%2Fhtml%22%7D%7D%7D%2C%22creatorSummary%22%3A%22Guis%20et%20al.%22%2C%22parsedDate%22%3A%222005-10%22%2C%22numChildren%22%3A4%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BGuis%2C%20S.%2C%20Mattei%2C%20J.-P.%2C%20Cozzone%2C%20P.J.%20and%20Bendahan%2C%20D.%20%282005%29%20%26%23x201C%3BPathophysiology%20and%20clinical%20presentations%20of%20rhabdomyolysis%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BJoint%2C%20bone%2C%20spine%3A%20revue%20du%20rhumatisme%26lt%3B%5C%2Fi%26gt%3B%2C%2072%285%29%2C%20pp.%20382%26%23x2013%3B391.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jbspin.2004.04.010%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jbspin.2004.04.010%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Pathophysiology%20and%20clinical%20presentations%20of%20rhabdomyolysis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sandrine%22%2C%22lastName%22%3A%22Guis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Pierre%22%2C%22lastName%22%3A%22Mattei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Patrick%20J%22%2C%22lastName%22%3A%22Cozzone%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Bendahan%22%7D%5D%2C%22abstractNote%22%3A%22Rhabdomyolysis%20has%20sparked%20new%20interest%20in%20recent%20years.%20The%20causes%20of%20rhabdomyolysis%20include%20drugs%20and%20other%20toxic%20agents%2C%20infections%2C%20physical%20exertion%2C%20crush%20injury%2C%20and%20muscle%20diseases%20%28dystrophinopathies%20and%20metabolic%20myopathies%29.%20Prompt%20identification%20of%20the%20pathophysiological%20mechanism%20is%20the%20key%20to%20rapid%20control%20of%20the%20acute%20episode%20and%20to%20prevention%20of%20recurrences.%20In%20this%20update%2C%20we%20discuss%20the%20pathophysiological%20mechanisms%20and%20nosology%20of%20rhabdomyolysis%2C%20as%20well%20as%20diagnostic%20investigations%2C%20with%20special%20emphasis%20on%20noninvasive%20methods.%22%2C%22date%22%3A%22Oct%202005%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.jbspin.2004.04.010%22%2C%22ISSN%22%3A%221297-319X%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22NW6SZQBR%22%2C%224ZGX55W3%22%2C%226BEMAGEW%22%5D%2C%22dateModified%22%3A%222015-09-04T09%3A16%3A16Z%22%7D%7D%2C%7B%22key%22%3A%229RUBRNJF%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22lastModifiedByUser%22%3A%7B%22id%22%3A1497928%2C%22username%22%3A%22fkober%22%2C%22name%22%3A%22Frank%20Kober%22%2C%22links%22%3A%7B%22alternate%22%3A%7B%22href%22%3A%22https%3A%5C%2F%5C%2Fwww.zotero.org%5C%2Ffkober%22%2C%22type%22%3A%22text%5C%2Fhtml%22%7D%7D%7D%2C%22creatorSummary%22%3A%22Guis%20et%20al.%22%2C%22parsedDate%22%3A%222004-11%22%2C%22numChildren%22%3A4%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BGuis%2C%20S.%2C%20Mattei%2C%20J.-P.%2C%20Pellissier%2C%20J.-F.%2C%20Nicoli%2C%20F.%2C%20Figarella-Branger%2C%20D.%2C%20Le%20Fur%2C%20Y.%2C%20Kaplanski%2C%20G.%2C%20Pelletier%2C%20J.%2C%20Harle%2C%20J.-R.%2C%20Cozzone%2C%20P.J.%20and%20Bendahan%2C%20D.%20%282004%29%20%26%23x201C%3BMRI%20and%2031PMR%20spectroscopy%20investigations%20of%20muscle%20function%20disclose%20no%20abnormality%20in%20macrophagic%20myofasciitis%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BThe%20Journal%20of%20rheumatology%26lt%3B%5C%2Fi%26gt%3B%2C%2031%2811%29%2C%20pp.%202313%26%23x2013%3B2314.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22MRI%20and%2031PMR%20spectroscopy%20investigations%20of%20muscle%20function%20disclose%20no%20abnormality%20in%20macrophagic%20myofasciitis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sandrine%22%2C%22lastName%22%3A%22Guis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Pierre%22%2C%22lastName%22%3A%22Mattei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Fran%5Cu00e7ois%22%2C%22lastName%22%3A%22Pellissier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fran%5Cu00e7ois%22%2C%22lastName%22%3A%22Nicoli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dominique%22%2C%22lastName%22%3A%22Figarella-Branger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yann%22%2C%22lastName%22%3A%22Le%20Fur%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gilles%22%2C%22lastName%22%3A%22Kaplanski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean%22%2C%22lastName%22%3A%22Pelletier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Robert%22%2C%22lastName%22%3A%22Harle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Patrick%20J%22%2C%22lastName%22%3A%22Cozzone%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Bendahan%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%22Nov%202004%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%22%22%2C%22ISSN%22%3A%220315-162X%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22SVI8UJ6H%22%2C%22NW6SZQBR%22%2C%224ZGX55W3%22%2C%22B4EWFM7E%22%2C%226BEMAGEW%22%5D%2C%22dateModified%22%3A%222015-09-04T09%3A16%3A17Z%22%7D%7D%2C%7B%22key%22%3A%22HUMQKS45%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22lastModifiedByUser%22%3A%7B%22id%22%3A1497928%2C%22username%22%3A%22fkober%22%2C%22name%22%3A%22Frank%20Kober%22%2C%22links%22%3A%7B%22alternate%22%3A%7B%22href%22%3A%22https%3A%5C%2F%5C%2Fwww.zotero.org%5C%2Ffkober%22%2C%22type%22%3A%22text%5C%2Fhtml%22%7D%7D%7D%2C%22creatorSummary%22%3A%22Bendahan%20et%20al.%22%2C%22parsedDate%22%3A%222004-09%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BBendahan%2C%20D.%2C%20Guis%2C%20S.%2C%20Monnier%2C%20N.%2C%20Kozak-Ribbens%2C%20G.%2C%20Lunardi%2C%20J.%2C%20Ghattas%2C%20B.%2C%20Mattei%2C%20J.-P.%20and%20Cozzone%2C%20P.J.%20%282004%29%20%26%23x201C%3BComparative%20analysis%20of%20in%20vitro%20contracture%20tests%20with%20ryanodine%20and%20a%20combination%20of%20ryanodine%20with%20either%20halothane%20or%20caffeine%3A%20a%20comparative%20investigation%20in%20malignant%20hyperthermia%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BActa%20anaesthesiologica%20Scandinavica%26lt%3B%5C%2Fi%26gt%3B%2C%2048%288%29%2C%20pp.%201019%26%23x2013%3B1027.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fj.0001-5172.2004.00461.x%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fj.0001-5172.2004.00461.x%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Comparative%20analysis%20of%20in%20vitro%20contracture%20tests%20with%20ryanodine%20and%20a%20combination%20of%20ryanodine%20with%20either%20halothane%20or%20caffeine%3A%20a%20comparative%20investigation%20in%20malignant%20hyperthermia%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D%22%2C%22lastName%22%3A%22Bendahan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S%22%2C%22lastName%22%3A%22Guis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N%22%2C%22lastName%22%3A%22Monnier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G%22%2C%22lastName%22%3A%22Kozak-Ribbens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%22%2C%22lastName%22%3A%22Lunardi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B%22%2C%22lastName%22%3A%22Ghattas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J-P%22%2C%22lastName%22%3A%22Mattei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P%20J%22%2C%22lastName%22%3A%22Cozzone%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20The%20diagnosis%20of%20susceptibility%20to%20malignant%20hyperthermia%20%28MH%29%20is%20currently%20performed%20on%20muscle%20biopsies%20subjected%20to%20halothane-caffeine%20in%20vitro%20contracture%20tests%20%28IVCTs%29.%20There%20is%20a%20consensus%20on%20our%20need%20to%20improve%20the%20diagnostic%20potential%20of%20IVCTs%20if%20we%20are%20to%20maximize%20the%20information%20available%20for%20research%20and%20diagnosis%20in%20MH.%20This%20study%20was%20designed%20as%20a%20pilot%20comparative%20study%20and%20we%20aimed%20at%20comparing%20the%20ryanodine%20test%20and%20new%20tests%20using%20a%20combination%20of%20ryanodine%2C%20halothane%20and%20caffeine.%5CnMETHODS%3A%20One%20hundred%20and%20thirty-two%20subjects%20%2852%20MHS%20and%2080%20MHN%29%20were%20included%20in%20this%20study%20and%20new%20IVCTs%20were%20performed%20in%20additional%20muscle%20biopsy%20specimens.%20The%20contracture%20time-course%20was%20compared%20considering%20the%20onset%20time%20of%20contracture%20%28OT%29%20and%20the%20time%20to%20reach%20a%2010%20mN%20contracture%20%2810T%29.%20Cut-off%20values%20were%20determined%20using%20ROC%20analyses.%5CnRESULTS%3A%20For%20the%20ryanodine%20test%2C%20sensitivity%20and%20specificity%20calculated%20for%20OT%20were%2084.6%25%20and%2090.4%25%2C%20respectively%2C%20and%20were%20better%20than%20those%20obtained%20using%2010T.%20Combined%20tests%20using%20either%20caffeine%20and%20ryanodine%20or%20halothane%20and%20ryanodine%20did%20provide%20higher%20sensitivities%20%28from%2085.3%20to%2093.9%25%29.%20A%20better%20specificity%20was%20only%20observed%20for%20the%20IVC%20tests%20combining%20halothane%20%28cumulated%29%20and%20caffeine%20both%20with%20ryanodine%20%2893.9%25%20for%20both%29.%20The%20largest%20sensitivity%20was%20observed%20when%20halothane%20was%20used%20as%20a%20bolus%20and%20combined%20with%20ryanodine.%20The%20specificity%20was%20always%20larger%20with%20the%20combined%20tests%20as%20compared%20to%20the%20test%20using%20ryanodine%20alone%20%28from%2079.1%20to%2090.9%25%29.%20This%20superiority%20was%20confirmed%2C%20at%20least%20in%20part%2C%20when%20comparing%20genetic%20investigations%20and%20the%20results%20of%20new%20tests%20in%20a%20subgroup%20of%20subjects.%5CnCONCLUSIONS%3A%20This%20pilot%20study%20showed%20a%20clear%20diagnostic%20potential%20for%20new%20IVC%20tests%20combining%20halothane%2C%20the%20triggering%20agent%20of%20MH%2C%20and%20ryanodine%20acting%20at%20the%20calcium%20release%20channel%2C%20and%20should%20be%20considered%20as%20a%20first%20step%20in%20the%20investigation%20of%20combined%20tests.%22%2C%22date%22%3A%22Sep%202004%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1111%5C%2Fj.0001-5172.2004.00461.x%22%2C%22ISSN%22%3A%220001-5172%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22NW6SZQBR%22%2C%224ZGX55W3%22%2C%226BEMAGEW%22%5D%2C%22dateModified%22%3A%222024-10-29T10%3A45%3A29Z%22%7D%7D%2C%7B%22key%22%3A%228JM8FS4N%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Announ%20et%20al.%22%2C%22parsedDate%22%3A%222004-05%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BAnnoun%2C%20N.%2C%20Mattei%2C%20J.P.%2C%20Jaoua%2C%20S.%2C%20Fenollar%2C%20F.%2C%20Sati%2C%20H.%2C%20Chagnaud%2C%20C.%2C%20Roudier%2C%20J.%20and%20Guis%2C%20S.%20%282004%29%20%26%23x201C%3BMultifocal%20discitis%20caused%20by%20Staphylococcus%20warneri%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BJoint%2C%20Bone%2C%20Spine%3A%20Revue%20Du%20Rhumatisme%26lt%3B%5C%2Fi%26gt%3B%2C%2071%283%29%2C%20pp.%20240%26%23x2013%3B242.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2FS1297-319X%2803%2900126-X%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2FS1297-319X%2803%2900126-X%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Multifocal%20discitis%20caused%20by%20Staphylococcus%20warneri%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadia%22%2C%22lastName%22%3A%22Announ%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean%20Pierre%22%2C%22lastName%22%3A%22Mattei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sami%22%2C%22lastName%22%3A%22Jaoua%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florence%22%2C%22lastName%22%3A%22Fenollar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hicham%22%2C%22lastName%22%3A%22Sati%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christophe%22%2C%22lastName%22%3A%22Chagnaud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean%22%2C%22lastName%22%3A%22Roudier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sandrine%22%2C%22lastName%22%3A%22Guis%22%7D%5D%2C%22abstractNote%22%3A%22Staphylococcus%20warneri%20is%20a%20coagulase-negative%20staphylococcus%20that%20is%20a%20normal%20inhabitant%20of%20the%20skin%20but%20occasionally%20causes%20septicemia%20and%20endocarditis.%20We%20report%20a%20case%20of%20multifocal%20discitis%20caused%20by%20S.%20warneri%20in%20an%20immunocompetent%20patient.%20Only%20three%20cases%20of%20spinal%20S.%20warneri%20infections%20have%20been%20reported%20in%20the%20literature.%20They%20illustrate%20the%20atypical%20clinical%20presentation%2C%20with%20chronic%20pain%20of%20increasing%20severity%20in%20the%20thoracic%20or%20lumbar%20spine%20instead%20of%20the%20abrupt%20onset%20that%20characterizes%20S.%20aureus%20discitis.%20In%20our%20patient%2C%20despite%20the%20multifocal%20distribution%20of%20the%20lesions%2C%20heretofore%20unreported%2C%20clinical%20presentation%20suggested%20common%20low%20back%20pain.%20This%20presentation%20may%20be%20ascribable%20to%20the%20unique%20bacteriological%20characteristics%20of%20S.%20warneri.%20The%20case%20reported%20here%20illustrates%20the%20diagnostic%20challenges%20sometime%20raised%20by%20discitis%20due%20to%20coagulase-negative%20staphylococci.%22%2C%22date%22%3A%22May%202004%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1016%5C%2FS1297-319X%2803%2900126-X%22%2C%22ISSN%22%3A%221297-319X%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%226BEMAGEW%22%5D%2C%22dateModified%22%3A%222015-09-04T09%3A15%3A23Z%22%7D%7D%2C%7B%22key%22%3A%22TGIKISG3%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22lastModifiedByUser%22%3A%7B%22id%22%3A1495222%2C%22username%22%3A%22crmbmlab%22%2C%22name%22%3A%22crmbmlab%22%2C%22links%22%3A%7B%22alternate%22%3A%7B%22href%22%3A%22https%3A%5C%2F%5C%2Fwww.zotero.org%5C%2Fcrmbmlab%22%2C%22type%22%3A%22text%5C%2Fhtml%22%7D%7D%7D%2C%22creatorSummary%22%3A%22Mattei%20et%20al.%22%2C%22parsedDate%22%3A%222004-03%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BMattei%2C%20J.P.%2C%20Bendahan%2C%20D.%20and%20Cozzone%2C%20P.%20%282004%29%20%26%23x201C%3BP-31%20magnetic%20resonance%20spectroscopy.%20A%20tool%20for%20diagnostic%20purposes%20and%20pathophysiological%20insights%20in%20muscle%20diseases%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BReumatismo%26lt%3B%5C%2Fi%26gt%3B%2C%2056%281%29%2C%20pp.%209%26%23x2013%3B14.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22P-31%20magnetic%20resonance%20spectroscopy.%20A%20tool%20for%20diagnostic%20purposes%20and%20pathophysiological%20insights%20in%20muscle%20diseases%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%20P%22%2C%22lastName%22%3A%22Mattei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D%22%2C%22lastName%22%3A%22Bendahan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P%22%2C%22lastName%22%3A%22Cozzone%22%7D%5D%2C%22abstractNote%22%3A%2231P%20Magnetic%20Resonance%20Spectroscopy%20%28MRS%29%20is%20a%20potent%20tool%20allowing%20the%20investigation%20of%20muscle%20energetics%20in%20a%20noninvasive%20manner%20in%20humans.%20This%20review%20details%20the%20contribution%20of%2031P%20MRS%20to%20the%20diagnosis%20of%20metabolic%20myopathies%20and%20provides%20some%20clues%20for%20the%20use%20of%20this%20technique%20in%20a%20clinical%20perspective.%20Finally%2C%20the%20contribution%20of%2031P%20MRS%20to%20our%20understanding%20of%20the%20physiopathology%20of%20several%20other%20diseases%20is%20highlighted.%22%2C%22date%22%3A%222004%20Jan-Mar%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%22%22%2C%22ISSN%22%3A%220048-7449%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22NW6SZQBR%22%2C%224ZGX55W3%22%5D%2C%22dateModified%22%3A%222013-11-18T17%3A38%3A32Z%22%7D%7D%2C%7B%22key%22%3A%22Z4C6HJV3%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22lastModifiedByUser%22%3A%7B%22id%22%3A1497928%2C%22username%22%3A%22fkober%22%2C%22name%22%3A%22Frank%20Kober%22%2C%22links%22%3A%7B%22alternate%22%3A%7B%22href%22%3A%22https%3A%5C%2F%5C%2Fwww.zotero.org%5C%2Ffkober%22%2C%22type%22%3A%22text%5C%2Fhtml%22%7D%7D%7D%2C%22creatorSummary%22%3A%22Guis%20et%20al.%22%2C%22parsedDate%22%3A%222004-01%22%2C%22numChildren%22%3A3%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BGuis%2C%20S.%2C%20Figarella-Branger%2C%20D.%2C%20Monnier%2C%20N.%2C%20Bendahan%2C%20D.%2C%20Kozak-Ribbens%2C%20G.%2C%20Mattei%2C%20J.-P.%2C%20Lunardi%2C%20J.%2C%20Cozzone%2C%20P.J.%20and%20Pellissier%2C%20J.-F.%20%282004%29%20%26%23x201C%3BMultiminicore%20disease%20in%20a%20family%20susceptible%20to%20malignant%20hyperthermia%3A%20histology%2C%20in%20vitro%20contracture%20tests%2C%20and%20genetic%20characterization%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BArchives%20of%20neurology%26lt%3B%5C%2Fi%26gt%3B%2C%2061%281%29%2C%20pp.%20106%26%23x2013%3B113.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1001%5C%2Farchneur.61.1.106%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1001%5C%2Farchneur.61.1.106%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Multiminicore%20disease%20in%20a%20family%20susceptible%20to%20malignant%20hyperthermia%3A%20histology%2C%20in%20vitro%20contracture%20tests%2C%20and%20genetic%20characterization%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sandrine%22%2C%22lastName%22%3A%22Guis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dominique%22%2C%22lastName%22%3A%22Figarella-Branger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicole%22%2C%22lastName%22%3A%22Monnier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Bendahan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Genevi%5Cu00e8ve%22%2C%22lastName%22%3A%22Kozak-Ribbens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Pierre%22%2C%22lastName%22%3A%22Mattei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jo%5Cu00ebl%22%2C%22lastName%22%3A%22Lunardi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Patrick%20J%22%2C%22lastName%22%3A%22Cozzone%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Fran%5Cu00e7ois%22%2C%22lastName%22%3A%22Pellissier%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Histological%20anomalies%20associated%20with%20malignant%20hyperthermia%20%28MH%29%20have%20been%20scarcely%20reported.%20In%20some%20patients%20susceptible%20to%20MH%20%28MHS%29%2C%20central%20cores%20have%20been%20identified%20and%20a%20genetic%20association%20has%20been%20proposed%2C%20but%20multiminicore%20lesions%20have%20not%20been%20systematically%20reported.%5CnOBJECTIVE%3A%20To%20analyze%20the%20association%20between%20multiminicores%20and%20MHS%20in%20a%20large%20family%20with%20MH%20with%20an%20approach%20combining%20histology%2C%20in%20vitro%20contracture%20tests%2C%20and%20genetic%20analysis.%5CnPATIENTS%20AND%20METHODS%3A%20Twenty-nine%20members%20of%20an%20MH%20family%20%28147%20members%29%20were%20investigated.%5CnMAIN%20OUTCOME%20MEASURES%3A%20Muscle%20biopsy%20specimens%20were%20analyzed%20histologically%20and%20with%20in%20vitro%20contracture%20tests.%20Genetic%20analyses%20were%20performed%20to%20determine%20the%20presence%20of%20mutations%20in%20the%20ryanodine%20receptor%20%28RYR1%29%20gene.%5CnRESULTS%3A%20According%20to%20the%20gold%20standard%20in%20vitro%20contracture%20tests%2C%2017%20patients%20were%20diagnosed%20as%20having%20MHS%20and%2010%20as%20not%20being%20susceptible.%20Multiminicores%20were%20found%20in%2016%20of%20the%2017%20MHS%20patients%20and%20in%20a%20single%20nonsusceptible%20participant.%20A%20linkage%20between%20the%20MH%20trait%20and%20the%20RYR1%20locus%20in%20chromosome%2019%20was%20demonstrated%2C%20whereas%20no%20already%20known%20mutations%20were%20found.%20Two%20missense%20heterozygous%20mutations%20%28R2676W%20and%20T2787S%29%20were%20identified%20from%20sequencing%20of%20the%20entire%20coding%20complementary%20DNA.%20Overall%2C%20we%20found%20a%20significant%20association%20between%20MHS%20and%20the%20presence%20of%20multiminicores%20%28chi%282%29%20%3D%2026.5%2C%20P%26lt%3B.001%29%20on%20the%20one%20hand%20and%20the%20presence%20of%20new%20mutations%20in%20the%20RYR1%20gene%20%28chi%282%29%20%3D%2019.0%2C%20P%26lt%3B.001%29%20on%20the%20other%20hand.%20This%20remarkably%20high%20occurrence%20of%20multiminicores%20in%20an%20MHS%20family%20is%20uncommon%2C%20and%20genetic%20analyses%20indicate%20that%20the%20association%20between%20multiminicores%20and%20MHS%20is%20linked%20to%20a%20novel%20R2656W%20and%20T2787S%20substitution%20present%20on%20the%20same%20allele%20of%20the%20RYR1%20gene.%5CnCONCLUSIONS%3A%20These%20results%20indicate%20that%20multiminicore%20lesions%20are%20observed%20in%20MHS%20patients%20with%20neither%20clinical%20signs%20related%20to%20multiminicore%20disease%20nor%20histological%20features%20of%20congenital%20myopathies.%20These%20multiminicore%20lesions%20may%20be%20secondary%20to%20mutations%20in%20the%20RYR1%20gene.%20As%20a%20consequence%2C%20these%20patients%20must%20be%20distinguished%20from%20patients%20with%20multiminicore%20disease%20and%20from%20other%20MHS%20patients%20for%20whom%20multiminicores%20are%20not%20observed.%22%2C%22date%22%3A%22Jan%202004%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1001%5C%2Farchneur.61.1.106%22%2C%22ISSN%22%3A%220003-9942%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22NW6SZQBR%22%2C%224ZGX55W3%22%2C%226BEMAGEW%22%5D%2C%22dateModified%22%3A%222015-09-04T09%3A16%3A19Z%22%7D%7D%2C%7B%22key%22%3A%22SPPRDHHI%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22lastModifiedByUser%22%3A%7B%22id%22%3A1497928%2C%22username%22%3A%22fkober%22%2C%22name%22%3A%22Frank%20Kober%22%2C%22links%22%3A%7B%22alternate%22%3A%7B%22href%22%3A%22https%3A%5C%2F%5C%2Fwww.zotero.org%5C%2Ffkober%22%2C%22type%22%3A%22text%5C%2Fhtml%22%7D%7D%7D%2C%22creatorSummary%22%3A%22Guis%20et%20al.%22%2C%22parsedDate%22%3A%222003-04-15%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BGuis%2C%20S.%2C%20Bendahan%2C%20D.%2C%20Kozak-Ribbens%2C%20G.%2C%20Figarella-Branger%2C%20D.%2C%20Mattei%2C%20J.P.%2C%20Pellissier%2C%20J.F.%2C%20Treffouret%2C%20S.%2C%20Bernard%2C%20V.%2C%20Lando%2C%20A.%20and%20Cozzone%2C%20P.J.%20%282003%29%20%26%23x201C%3BRhabdomyolysis%20and%20myalgia%20associated%20with%20anticholesterolemic%20treatment%20as%20potential%20signs%20of%20malignant%20hyperthermia%20susceptibility%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BArthritis%20and%20rheumatism%26lt%3B%5C%2Fi%26gt%3B%2C%2049%282%29%2C%20pp.%20237%26%23x2013%3B238.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fart.11013%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fart.11013%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Rhabdomyolysis%20and%20myalgia%20associated%20with%20anticholesterolemic%20treatment%20as%20potential%20signs%20of%20malignant%20hyperthermia%20susceptibility%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S%22%2C%22lastName%22%3A%22Guis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D%22%2C%22lastName%22%3A%22Bendahan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G%22%2C%22lastName%22%3A%22Kozak-Ribbens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D%22%2C%22lastName%22%3A%22Figarella-Branger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%20P%22%2C%22lastName%22%3A%22Mattei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%20F%22%2C%22lastName%22%3A%22Pellissier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S%22%2C%22lastName%22%3A%22Treffouret%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22V%22%2C%22lastName%22%3A%22Bernard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A%22%2C%22lastName%22%3A%22Lando%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P%20J%22%2C%22lastName%22%3A%22Cozzone%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%22Apr%2015%2C%202003%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1002%5C%2Fart.11013%22%2C%22ISSN%22%3A%220004-3591%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%225Z6CVJGB%22%2C%22NW6SZQBR%22%2C%224ZGX55W3%22%2C%226BEMAGEW%22%5D%2C%22dateModified%22%3A%222015-09-04T09%3A16%3A23Z%22%7D%7D%2C%7B%22key%22%3A%2277ZXVSXX%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22lastModifiedByUser%22%3A%7B%22id%22%3A1497928%2C%22username%22%3A%22fkober%22%2C%22name%22%3A%22Frank%20Kober%22%2C%22links%22%3A%7B%22alternate%22%3A%7B%22href%22%3A%22https%3A%5C%2F%5C%2Fwww.zotero.org%5C%2Ffkober%22%2C%22type%22%3A%22text%5C%2Fhtml%22%7D%7D%7D%2C%22creatorSummary%22%3A%22Roussel%20et%20al.%22%2C%22parsedDate%22%3A%222003-03%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BRoussel%2C%20M.%2C%20Mattei%2C%20J.P.%2C%20Le%20Fur%2C%20Y.%2C%20Ghattas%2C%20B.%2C%20Cozzone%2C%20P.J.%20and%20Bendahan%2C%20D.%20%282003%29%20%26%23x201C%3BMetabolic%20determinants%20of%20the%20onset%20of%20acidosis%20in%20exercising%20human%20muscle%3A%20a%2031P-MRS%20study%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BJournal%20of%20applied%20physiology%20%28Bethesda%2C%20Md.%3A%201985%29%26lt%3B%5C%2Fi%26gt%3B%2C%2094%283%29%2C%20pp.%201145%26%23x2013%3B1152.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1152%5C%2Fjapplphysiol.01024.2000%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1152%5C%2Fjapplphysiol.01024.2000%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Metabolic%20determinants%20of%20the%20onset%20of%20acidosis%20in%20exercising%20human%20muscle%3A%20a%2031P-MRS%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M%22%2C%22lastName%22%3A%22Roussel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%20P%22%2C%22lastName%22%3A%22Mattei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Y%22%2C%22lastName%22%3A%22Le%20Fur%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B%22%2C%22lastName%22%3A%22Ghattas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P%20J%22%2C%22lastName%22%3A%22Cozzone%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D%22%2C%22lastName%22%3A%22Bendahan%22%7D%5D%2C%22abstractNote%22%3A%22Onset%20of%20intracellular%20acidosis%20during%20muscular%20exercise%20has%20been%20generally%20attributed%20to%20activation%20or%20hyperactivation%20of%20nonoxidative%20ATP%20production%20but%20has%20not%20been%20analyzed%20quantitatively%20in%20terms%20of%20H%28%2B%29%20balance%2C%20i.e.%2C%20production%20and%20removal%20mechanisms.%20To%20address%20this%20issue%2C%20we%20have%20analyzed%20the%20relation%20of%20intracellular%20acidosis%20to%20H%28%2B%29%20balance%20during%20exercise%20bouts%20in%20seven%20healthy%20subjects.%20Each%20subject%20performed%20a%206-min%20ramp%20rhythmic%20exercise%20%28finger%20flexions%29%20at%20low%20frequency%20%28LF%2C%200.47%20Hz%29%2C%20leading%20to%20slight%20acidosis%2C%20and%20at%20high%20frequency%20%28HF%2C%200.85%20Hz%29%2C%20inducing%20a%20larger%20acidosis.%20Metabolic%20changes%20were%20recorded%20using%20%2831%29P-magnetic%20resonance%20spectroscopy.%20Onset%20of%20intracellular%20acidosis%20was%20statistically%20identified%20after%203%20and%204%20min%20of%20exercise%20for%20HF%20and%20LF%20protocols%2C%20respectively.%20A%20detailed%20investigation%20of%20H%28%2B%29%20balance%20indicated%20that%2C%20for%20both%20protocols%2C%20nonoxidative%20ATP%20production%20preceded%20a%20change%20in%20pH.%20For%20HF%20and%20LF%20protocols%2C%20H%28%2B%29%20consumption%20through%20the%20creatine%20kinase%20equilibrium%20was%20constant%20in%20the%20face%20of%20increasing%20H%28%2B%29%20generation%20and%20efflux.%20For%20both%20protocols%2C%20changes%20in%20pH%20were%20not%20recorded%20as%20long%20as%20sources%20and%20sinks%20for%20H%28%2B%29%20approximately%20balanced.%20In%20contrast%2C%20a%20significant%20acidosis%20occurred%20after%204%20min%20of%20LF%20exercise%20and%203%20min%20of%20HF%20exercise%2C%20whereas%20the%20rise%20in%20H%28%2B%29%20generation%20exceeded%20the%20rise%20in%20H%28%2B%29%20efflux%20at%20a%20nearly%20constant%20H%28%2B%29%20uptake%20associated%20with%20phosphocreatine%20breakdown.%20We%20have%20clearly%20demonstrated%20that%20intracellular%20acidosis%20in%20exercising%20muscle%20does%20not%20occur%20exclusively%20as%20a%20result%20of%20nonoxidative%20ATP%20production%20but%2C%20rather%2C%20reflects%20changes%20in%20overall%20H%28%2B%29%20balance.%22%2C%22date%22%3A%22Mar%202003%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1152%5C%2Fjapplphysiol.01024.2000%22%2C%22ISSN%22%3A%228750-7587%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22SVI8UJ6H%22%2C%22NW6SZQBR%22%2C%224ZGX55W3%22%5D%2C%22dateModified%22%3A%222022-02-24T14%3A28%3A17Z%22%7D%7D%2C%7B%22key%22%3A%22VINE3GBB%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Guis%20et%20al.%22%2C%22parsedDate%22%3A%222002-10-15%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BGuis%2C%20S.%2C%20Mattei%2C%20J.P.%2C%20Nicoli%2C%20F.%2C%20Pellissier%2C%20J.F.%2C%20Kaplanski%2C%20G.%2C%20Figarella-Branger%2C%20D.%2C%20Manez%2C%20G.C.%2C%20Antipoff%2C%20G.M.%20and%20Roudier%2C%20J.%20%282002%29%20%26%23x201C%3BIdentical%20twins%20with%20macrophagic%20myofasciitis%3A%20genetic%20susceptibility%20and%20triggering%20by%20aluminic%20vaccine%20adjuvants%3F%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BArthritis%20and%20Rheumatism%26lt%3B%5C%2Fi%26gt%3B%2C%2047%285%29%2C%20pp.%20543%26%23x2013%3B545.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fart.10666%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fart.10666%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Identical%20twins%20with%20macrophagic%20myofasciitis%3A%20genetic%20susceptibility%20and%20triggering%20by%20aluminic%20vaccine%20adjuvants%3F%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Guis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%20P.%22%2C%22lastName%22%3A%22Mattei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22F.%22%2C%22lastName%22%3A%22Nicoli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%20F.%22%2C%22lastName%22%3A%22Pellissier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G.%22%2C%22lastName%22%3A%22Kaplanski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D.%22%2C%22lastName%22%3A%22Figarella-Branger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G.%20C.%22%2C%22lastName%22%3A%22Manez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G.%20M.%22%2C%22lastName%22%3A%22Antipoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Roudier%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%22Oct%2015%2C%202002%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1002%5C%2Fart.10666%22%2C%22ISSN%22%3A%220004-3591%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%226BEMAGEW%22%5D%2C%22dateModified%22%3A%222015-09-04T09%3A15%3A23Z%22%7D%7D%2C%7B%22key%22%3A%22R4DPC4ZU%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Guis%20et%20al.%22%2C%22parsedDate%22%3A%222002-09%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BGuis%2C%20S.%2C%20Pellissier%2C%20J.-F.%2C%20Nicoli%2C%20F.%2C%20Reviron%2C%20D.%2C%20Mattei%2C%20J.-P.%2C%20Gherardi%2C%20R.K.%2C%20Pelletier%2C%20J.%2C%20Kaplanski%2C%20G.%2C%20Figarella-Branger%2C%20D.%20and%20Roudier%2C%20J.%20%282002%29%20%26%23x201C%3BHLA-DRB1%2A01%20and%20macrophagic%20myofasciitis%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BArthritis%20and%20Rheumatism%26lt%3B%5C%2Fi%26gt%3B%2C%2046%289%29%2C%20pp.%202535%26%23x2013%3B2537.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fart.10465%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fart.10465%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22HLA-DRB1%2A01%20and%20macrophagic%20myofasciitis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sandrine%22%2C%22lastName%22%3A%22Guis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Fran%5Cu00e7ois%22%2C%22lastName%22%3A%22Pellissier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fran%5Cu00e7ois%22%2C%22lastName%22%3A%22Nicoli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Denis%22%2C%22lastName%22%3A%22Reviron%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Pierre%22%2C%22lastName%22%3A%22Mattei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Romain%20K.%22%2C%22lastName%22%3A%22Gherardi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean%22%2C%22lastName%22%3A%22Pelletier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gilles%22%2C%22lastName%22%3A%22Kaplanski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dominique%22%2C%22lastName%22%3A%22Figarella-Branger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean%22%2C%22lastName%22%3A%22Roudier%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%22Sep%202002%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1002%5C%2Fart.10465%22%2C%22ISSN%22%3A%220004-3591%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22B4EWFM7E%22%2C%226BEMAGEW%22%5D%2C%22dateModified%22%3A%222015-09-04T09%3A15%3A23Z%22%7D%7D%2C%7B%22key%22%3A%224K4PGMP5%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22lastModifiedByUser%22%3A%7B%22id%22%3A1495222%2C%22username%22%3A%22crmbmlab%22%2C%22name%22%3A%22crmbmlab%22%2C%22links%22%3A%7B%22alternate%22%3A%7B%22href%22%3A%22https%3A%5C%2F%5C%2Fwww.zotero.org%5C%2Fcrmbmlab%22%2C%22type%22%3A%22text%5C%2Fhtml%22%7D%7D%7D%2C%22creatorSummary%22%3A%22Bendahan%20et%20al.%22%2C%22parsedDate%22%3A%222002-08%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BBendahan%2C%20D.%2C%20Mattei%2C%20J.P.%2C%20Ghattas%2C%20B.%2C%20Confort-Gouny%2C%20S.%2C%20Le%20Guern%2C%20M.E.%20and%20Cozzone%2C%20P.J.%20%282002%29%20%26%23x201C%3BCitrulline%5C%2Fmalate%20promotes%20aerobic%20energy%20production%20in%20human%20exercising%20muscle%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BBritish%20journal%20of%20sports%20medicine%26lt%3B%5C%2Fi%26gt%3B%2C%2036%284%29%2C%20pp.%20282%26%23x2013%3B289.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Citrulline%5C%2Fmalate%20promotes%20aerobic%20energy%20production%20in%20human%20exercising%20muscle%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D%22%2C%22lastName%22%3A%22Bendahan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%20P%22%2C%22lastName%22%3A%22Mattei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B%22%2C%22lastName%22%3A%22Ghattas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S%22%2C%22lastName%22%3A%22Confort-Gouny%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M%20E%22%2C%22lastName%22%3A%22Le%20Guern%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P%20J%22%2C%22lastName%22%3A%22Cozzone%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Previous%20studies%20have%20shown%20an%20antiasthenic%20effect%20of%20citrulline%5C%2Fmalate%20%28CM%29%20but%20the%20mechanism%20of%20action%20at%20the%20muscular%20level%20remains%20unknown.%5CnOBJECTIVE%3A%20To%20investigate%20the%20effects%20of%20CM%20supplementation%20on%20muscle%20energetics.%5CnMETHODS%3A%20Eighteen%20men%20complaining%20of%20fatigue%20but%20with%20no%20documented%20disease%20were%20included%20in%20the%20study.%20A%20rest-exercise%20%28finger%20flexions%29-recovery%20protocol%20was%20performed%20twice%20before%20%28D-7%20and%20D0%29%2C%20three%20times%20during%20%28D3%2C%20D8%2C%20D15%29%2C%20and%20once%20after%20%28D22%29%2015%20days%20of%20oral%20supplementation%20with%206%20g%5C%2Fday%20CM.%20Metabolism%20of%20the%20flexor%20digitorum%20superficialis%20was%20analysed%20by%20%2831%29P%20magnetic%20resonance%20spectroscopy%20at%204.7%20T.%5CnRESULTS%3A%20Metabolic%20variables%20measured%20twice%20before%20CM%20ingestion%20showed%20no%20differences%2C%20indicating%20good%20reproducibility%20of%20measurements%20and%20no%20learning%20effect%20from%20repeating%20the%20exercise%20protocol.%20CM%20ingestion%20resulted%20in%20a%20significant%20reduction%20in%20the%20sensation%20of%20fatigue%2C%20a%2034%25%20increase%20in%20the%20rate%20of%20oxidative%20ATP%20production%20during%20exercise%2C%20and%20a%2020%25%20increase%20in%20the%20rate%20of%20phosphocreatine%20recovery%20after%20exercise%2C%20indicating%20a%20larger%20contribution%20of%20oxidative%20ATP%20synthesis%20to%20energy%20production.%20Considering%20subjects%20individually%20and%20variables%20characterising%20aerobic%20function%2C%20extrema%20were%20measured%20after%20either%20eight%20or%2015%20days%20of%20treatment%2C%20indicating%20chronological%20heterogeneity%20of%20treatment%20induced%20changes.%20One%20way%20analysis%20of%20variance%20confirmed%20improved%20aerobic%20function%2C%20which%20may%20be%20the%20result%20of%20an%20enhanced%20malate%20supply%20activating%20ATP%20production%20from%20the%20tricarboxylic%20acid%20cycle%20through%20anaplerotic%20reactions.%5CnCONCLUSION%3A%20The%20changes%20in%20muscle%20metabolism%20produced%20by%20CM%20treatment%20indicate%20that%20CM%20may%20promote%20aerobic%20energy%20production.%22%2C%22date%22%3A%22Aug%202002%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%22%22%2C%22ISSN%22%3A%220306-3674%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%227JR7EDKF%22%2C%22NW6SZQBR%22%2C%224ZGX55W3%22%5D%2C%22dateModified%22%3A%222015-02-27T08%3A38%3A39Z%22%7D%7D%2C%7B%22key%22%3A%226VUHBZTP%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22lastModifiedByUser%22%3A%7B%22id%22%3A1495222%2C%22username%22%3A%22crmbmlab%22%2C%22name%22%3A%22crmbmlab%22%2C%22links%22%3A%7B%22alternate%22%3A%7B%22href%22%3A%22https%3A%5C%2F%5C%2Fwww.zotero.org%5C%2Fcrmbmlab%22%2C%22type%22%3A%22text%5C%2Fhtml%22%7D%7D%7D%2C%22creatorSummary%22%3A%22Mattei%20et%20al.%22%2C%22parsedDate%22%3A%222002-04-22%22%2C%22numChildren%22%3A3%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BMattei%2C%20J.-P.%2C%20Kozak-Ribbens%2C%20G.%2C%20Roussel%2C%20M.%2C%20Le%20Fur%2C%20Y.%2C%20Cozzone%2C%20P.J.%20and%20Bendahan%2C%20D.%20%282002%29%20%26%23x201C%3BNew%20parameters%20reducing%20the%20interindividual%20variability%20of%20metabolic%20changes%20during%20muscle%20contraction%20in%20humans.%20A%20%2831%29P%20MRS%20study%20with%20physiological%20and%20clinical%20implications%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BBiochimica%20et%20biophysica%20acta%26lt%3B%5C%2Fi%26gt%3B%2C%201554%281%26%23x2013%3B2%29%2C%20pp.%20129%26%23x2013%3B136.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22New%20parameters%20reducing%20the%20interindividual%20variability%20of%20metabolic%20changes%20during%20muscle%20contraction%20in%20humans.%20A%20%2831%29P%20MRS%20study%20with%20physiological%20and%20clinical%20implications%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Pierre%22%2C%22lastName%22%3A%22Mattei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Genevi%5Cu00e8ve%22%2C%22lastName%22%3A%22Kozak-Ribbens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Magali%22%2C%22lastName%22%3A%22Roussel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yann%22%2C%22lastName%22%3A%22Le%20Fur%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Patrick%20J%22%2C%22lastName%22%3A%22Cozzone%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Bendahan%22%7D%5D%2C%22abstractNote%22%3A%22Interindividual%20variations%20in%20skeletal%20muscle%20metabolism%20make%20comparative%20analyses%20difficult.%20In%20this%20study%2C%20we%20have%20addressed%20the%20issue%20of%20capturing%20the%20variability%20of%20metabolic%20performance%20observed%20during%20muscle%20exercise%20in%20humans%20by%20using%20an%20original%20method%20of%20normalization.Metabolic%20changes%20induced%20by%20various%20kinds%20of%20exercise%20were%20investigated%20using%2031P%20magnetic%20resonance%20spectroscopy%20%28MRS%29%20at%204.7%20T%20in%2065%20normal%20subjects%20%2823%20women%20and%2042%20men%29%20and%2012%20patients%20with%20biopsy-proven%20muscular%20disorders.%20Large%20variations%20in%20the%20extent%20of%20PCr%20breakdown%20and%20intracellular%20acidosis%20were%20recorded%20among%20subjects%20and%20exercise%20protocols.%20For%20all%20the%20data%20pooled%2C%20the%20amplitude%20of%20mechanical%20performance%20accounts%20for%2050%25%20of%20these%20variations.%20When%20scaled%20to%20the%20work%20output%2C%20variations%20of%20PCr%20consumption%20account%20for%2065%25%20of%20pH%20changes%20through%20a%20linear%20relationship.%20This%20linear%20relationship%20was%20substantially%20improved%20%2890%25%29%20when%20both%20variables%20were%20scaled%20to%20the%20square%20of%20work%20output%20performed%20%28P1%20and%20P2%29.%20By%20capturing%20most%20of%20the%20initial%20interindividual%20variability%20%2890%25%29%2C%20P1%20vs.%20P2%20relationship%20represents%20an%20ideal%20standardization%20procedure%2C%20independent%20of%20any%20anthropometric%20measurements.%20This%20relationship%20also%20discloses%20a%20significant%20link%20between%20the%20extent%20of%20PCr%20breakdown%20and%20intracellular%20acidosis%20regardless%20of%20exercise%20protocol.%20Moreover%2C%20changes%20in%20the%20slope%20of%20the%20P1%20vs.%20P2%20regression%20curve%2C%20as%20measured%20in%20old%20subjects%20and%20in%20selected%20patients%2C%20directly%20reflect%20alterations%20of%20energy%20production%20in%20muscle.%22%2C%22date%22%3A%22Apr%2022%2C%202002%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%22%22%2C%22ISSN%22%3A%220006-3002%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22SVI8UJ6H%22%2C%22NW6SZQBR%22%2C%224ZGX55W3%22%5D%2C%22dateModified%22%3A%222013-11-22T11%3A09%3A47Z%22%7D%7D%2C%7B%22key%22%3A%22SQ2XIPQZ%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22lastModifiedByUser%22%3A%7B%22id%22%3A1497928%2C%22username%22%3A%22fkober%22%2C%22name%22%3A%22Frank%20Kober%22%2C%22links%22%3A%7B%22alternate%22%3A%7B%22href%22%3A%22https%3A%5C%2F%5C%2Fwww.zotero.org%5C%2Ffkober%22%2C%22type%22%3A%22text%5C%2Fhtml%22%7D%7D%7D%2C%22creatorSummary%22%3A%22Guis%20et%20al.%22%2C%22parsedDate%22%3A%222002-03%22%2C%22numChildren%22%3A4%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BGuis%2C%20S.%2C%20Bendahan%2C%20D.%2C%20Kozak-Ribbens%2C%20G.%2C%20Mattei%2C%20J.P.%2C%20Le%20Fur%2C%20Y.%2C%20Confort-Gouny%2C%20S.%2C%20Figarella-Branger%2C%20D.%2C%20Jouglard%2C%20J.%20and%20Cozzone%2C%20P.J.%20%282002%29%20%26%23x201C%3BInvestigation%20of%20fluoroquinolone-induced%20myalgia%20using%20%2831%29P%20magnetic%20resonance%20spectroscopy%20and%20in%20vitro%20contracture%20tests%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BArthritis%20and%20rheumatism%26lt%3B%5C%2Fi%26gt%3B%2C%2046%283%29%2C%20pp.%20774%26%23x2013%3B778.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fart.10094%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fart.10094%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Investigation%20of%20fluoroquinolone-induced%20myalgia%20using%20%2831%29P%20magnetic%20resonance%20spectroscopy%20and%20in%20vitro%20contracture%20tests%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S%22%2C%22lastName%22%3A%22Guis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D%22%2C%22lastName%22%3A%22Bendahan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G%22%2C%22lastName%22%3A%22Kozak-Ribbens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%20P%22%2C%22lastName%22%3A%22Mattei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Y%22%2C%22lastName%22%3A%22Le%20Fur%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S%22%2C%22lastName%22%3A%22Confort-Gouny%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D%22%2C%22lastName%22%3A%22Figarella-Branger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%22%2C%22lastName%22%3A%22Jouglard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P%20J%22%2C%22lastName%22%3A%22Cozzone%22%7D%5D%2C%22abstractNote%22%3A%22OBJECTIVE%3A%20To%20investigate%20muscle%20function%20in%20patients%20with%20severe%20myalgia%20resulting%20from%20fluoroquinolone%20%28FQ%29%20treatment.%20We%20used%20histology%2C%20in%20vitro%20contracture%20tests%20%28IVCTs%29%2C%20and%20%2831%29P%20magnetic%20resonance%20spectroscopy%20%28%2831%29P%20MRS%29%20to%20explore%20muscle%20contraction%20and%20metabolism.%5CnMETHODS%3A%20We%20studied%203%20patients%20with%20myalgia%2C%20hyperalgia%20tendinopathy%2C%20and%20arthralgia%20following%20FQ%20treatment%20and%203%20normal%20subjects%20after%20taking%20FQs.%20Results%20were%20compared%20with%20those%20of%20a%20control%20group%20of%209%20subjects%20free%20of%20any%20muscle%20disease%20and%20not%20taking%20FQs.%20Muscle%20biopsies%20were%20performed%20on%20the%20left%20biceps%2C%20and%20IVCTs%20were%20performed%20in%20accordance%20with%20the%20protocol%20recommended%20by%20the%20European%20Malignant%20Hyperthermia%20Group.%20%2831%29P%20MR%20spectra%20of%20forearm%20flexor%20muscles%20were%20recorded%20at%204.7T%20throughout%20a%20rest-exercise-recovery%20protocol.%5CnRESULTS%3A%20%2831%29P%20MRS%20showed%20a%20significant%20reduction%20of%20pH%20changes%20measured%20at%20the%20end%20of%20exercise%20and%20a%20faster%20rate%20of%20proton%20efflux%20measured%20during%20recovery%20in%20all%20patients.%20IVCTs%20diagnosed%201%20patient%20as%20being%20susceptible%20to%20malignant%20hyperthermia.%20No%20specific%20histologic%20anomalies%20were%20observed%20in%20muscle%20biopsy%20samples%2C%20which%20showed%20normal%20mitochondria.%5CnCONCLUSION%3A%20The%20adverse%20effects%20recorded%20in%20the%203%20patients%20are%20related%20to%20a%20preexisting%20muscular%20anomaly%20revealed%20by%20FQ%20treatment.%22%2C%22date%22%3A%22Mar%202002%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1002%5C%2Fart.10094%22%2C%22ISSN%22%3A%220004-3591%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22SVI8UJ6H%22%2C%227JR7EDKF%22%2C%22NW6SZQBR%22%2C%224ZGX55W3%22%2C%226BEMAGEW%22%5D%2C%22dateModified%22%3A%222015-09-04T09%3A16%3A26Z%22%7D%7D%2C%7B%22key%22%3A%22X9J6AQK6%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Camacho%20et%20al.%22%2C%22parsedDate%22%3A%222002-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BCamacho%2C%20M.%2C%20Guis%2C%20S.%2C%20Mattei%2C%20J.-P.%2C%20Costello%2C%20R.%20and%20Roudier%2C%20J.%20%282002%29%20%26%23x201C%3BThree-year%20outcome%20in%20a%20patient%20with%20Staphylococcus%20lugdunensis%20discitis%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BJoint%2C%20Bone%2C%20Spine%3A%20Revue%20Du%20Rhumatisme%26lt%3B%5C%2Fi%26gt%3B%2C%2069%281%29%2C%20pp.%2085%26%23x2013%3B87.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Three-year%20outcome%20in%20a%20patient%20with%20Staphylococcus%20lugdunensis%20discitis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mildreth%22%2C%22lastName%22%3A%22Camacho%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sandrine%22%2C%22lastName%22%3A%22Guis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Pierre%22%2C%22lastName%22%3A%22Mattei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R%5Cu00e9gis%22%2C%22lastName%22%3A%22Costello%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean%22%2C%22lastName%22%3A%22Roudier%22%7D%5D%2C%22abstractNote%22%3A%22The%20few%20reported%20cases%20of%20bone%20and%20joint%20infection%20by%20Staphylococcus%20lugdunensis%20indicate%20that%20the%20clinical%20manifestations%20are%20severe%2C%20the%20diagnosis%20elusive%2C%20and%20the%20treatment%20difficult.%20We%20report%20a%20case%20of%20lumbar%20discitis%20caused%20by%20Staphylococcus%20lugdunensis%20in%20a%2067-year-old%20man%20receiving%20chemotherapy%20for%20stage%20III%20IgA%20lambda%20multiple%20myeloma.%20Treatment%20was%20with%20ofloxacin%20and%20pristinamycin%20for%201%20year.%20Although%20he%20started%20to%20improve%20only%205%20months%20after%20treatment%20initiation%2C%20the%20outcome%20was%20favorable.%20Follow-up%20at%20the%20time%20of%20this%20writing%20is%203%20years.%22%2C%22date%22%3A%22Jan%202002%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%22%22%2C%22ISSN%22%3A%221297-319X%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%226BEMAGEW%22%5D%2C%22dateModified%22%3A%222015-09-04T09%3A15%3A23Z%22%7D%7D%5D%7D
Guenoun, D., Wirth, T., Roche, D., Michel, C.P., Daudé, P., Ogier, A.C., Chagnaud, C., Mattei, J.P., Pini, L., Guye, M., Ollivier, M., Bendahan, D. and Guis, S. (2023) “Ultra-high field magnetic resonance imaging of the quadriceps tendon enthesis in healthy subjects,” Surgical and Radiologic Anatomy, 45(8), pp. 1049–1054. Available at: https://doi.org/10.1007/s00276-023-03175-y.
Soldati, E., Escoffier, L., Gabriel, S., Ogier, A.C., Chagnaud, C., Mattei, J.P., Cammilleri, S., Bendahan, D. and Guis, S. (2021) “Assessment of in vivo bone microarchitecture changes in an anti-TNFα treated psoriatic arthritic patient,” PloS One, 16(5), p. e0251788. Available at: https://doi.org/10.1371/journal.pone.0251788.
Poullain, F., Mattei, J.C., Rochwerger, A., Bouvier, C., Chagnaud, C., Champsaur, P. and Le Corroller, T. (2020) “Percutaneous cryoablation of osteoblastoma in the proximal femur,” Skeletal Radiology, 49(9), pp. 1467–1471. Available at: https://doi.org/10.1007/s00256-020-03413-z.
Brui, E., Efimtcev, A.Y., Fokin, V.A., Fernandez, R., Levchuk, A.G., Ogier, A.C., Samsonov, A.A., Mattei, J.P., Melchakova, I.V., Bendahan, D. and Andreychenko, A. (2020) “Deep learning-based fully automatic segmentation of wrist cartilage in MR images,” NMR in biomedicine, 33(8), p. e4320. Available at: https://doi.org/10.1002/nbm.4320.
Guenoun, D., Pithioux, M., Souplet, J.-C., Guis, S., Le Corroller, T., Fouré, A., Pauly, V., Mattei, J.-P., Bernard, M., Guye, M., Chabrand, P., Champsaur, P. and Bendahan, D. (2020) “Assessment of proximal femur microarchitecture using ultra-high field MRI at 7 Tesla,” Diagnostic and Interventional Imaging, 101(1), pp. 45–53. Available at: https://doi.org/10.1016/j.diii.2019.06.013.
Cammilleri, S., Gabriel, S., Le Troter, A., Chagnaud, C., Mattei, J.P., Bendahan, D. and Guis, S. (2019) “Knee psoriatic enthesitis assessed using positron emission tomography (PET) - FNa merged to ultrahigh field magnetic resonance imaging (UHF-MRI),” Joint Bone Spine, 86(3), pp. 387–388. Available at: https://doi.org/10.1016/j.jbspin.2019.01.002.
Fouré, A., Pini, L., Rappacchi, S., Ogier, A.C., Mattei, J.-C., Bydder, M., Guye, M. and Bendahan, D. (2019) “Ultrahigh-Field Multimodal MRI Assessment of Muscle Damage,” Journal of magnetic resonance imaging: JMRI, 49(3), pp. 904–906. Available at: https://doi.org/10.1002/jmri.26222.
Louis, M.L., Magalon, J., Jouve, E., Bornet, C.E., Mattei, J.C., Chagnaud, C., Rochwerger, A., Veran, J. and Sabatier, F. (2018) “Growth Factors Levels Determine Efficacy of Platelets Rich Plasma Injection in Knee Osteoarthritis: A Randomized Double Blind Noninferiority Trial Compared With Viscosupplementation,” Arthroscopy: The Journal of Arthroscopic & Related Surgery: Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association, 34(5), pp. 1530-1540.e2. Available at: https://doi.org/10.1016/j.arthro.2017.11.035.
Guenoun, D., Fouré, A., Pithioux, M., Guis, S., Le Corroller, T., Mattei, J.-P., Pauly, V., Guye, M., Bernard, M., Chabrand, P., Champsaur, P. and Bendahan, D. (2017) “Correlative Analysis of Vertebral Trabecular Bone Microarchitecture and Mechanical Properties: A Combined Ultra-high Field (7 Tesla) MRI and Biomechanical Investigation,” Spine, 42(20), pp. E1165–E1172. Available at: https://doi.org/10.1097/BRS.0000000000002163.
Wegrzyk, J., Ranjeva, J.-P., Fouré, A., Kavounoudias, A., Vilmen, C., Mattei, J.-P., Guye, M., Maffiuletti, N.A., Place, N., Bendahan, D. and Gondin, J. (2017) “Specific brain activation patterns associated with two neuromuscular electrical stimulation protocols,” Scientific Reports, 7(1), p. 2742. Available at: https://doi.org/10.1038/s41598-017-03188-9.
Martin, A., Grosprêtre, S., Vilmen, C., Guye, M., Mattei, J.-P., LE Fur, Y., Bendahan, D. and Gondin, J. (2016) “The Etiology of Muscle Fatigue Differs between Two Electrical Stimulation Protocols,” Medicine and Science in Sports and Exercise, 48(8), pp. 1474–1484. Available at: https://doi.org/10.1249/MSS.0000000000000930.
Montoya, J., Matta, N.B., Suchon, P., Guzian, M.C., Lambert, N.C., Mattei, J.P., Guis, S., Breban, M., Roudier, J. and Balandraud, N. (2016) “Patients with ankylosing spondylitis have been breast fed less often than healthy controls: a case-control retrospective study,” Annals of the Rheumatic Diseases, 75(5), pp. 879–882. Available at: https://doi.org/10.1136/annrheumdis-2015-208187.
Le Troter, A., Fouré, A., Guye, M., Confort-Gouny, S., Mattei, J.-P., Gondin, J., Salort-Campana, E. and Bendahan, D. (2016) “Volume measurements of individual muscles in human quadriceps femoris using atlas-based segmentation approaches,” Magma (New York, N.Y.), 29(2), pp. 245–257. Available at: https://doi.org/10.1007/s10334-016-0535-6.
Fouré, A., Nosaka, K., Gastaldi, M., Mattei, J.-P., Boudinet, H., Guye, M., Vilmen, C., Le Fur, Y., Bendahan, D. and Gondin, J. (2016) “Effects of branched-chain amino acids supplementation on both plasma amino acids concentration and muscle energetics changes resulting from muscle damage: A randomized placebo controlled trial,” Clinical Nutrition (Edinburgh, Scotland), 35(1), pp. 83–94. Available at: https://doi.org/10.1016/j.clnu.2015.03.014.
Zink, J.-V., Souteyrand, P., Guis, S., Chagnaud, C., Fur, Y.L., Militianu, D., Mattei, J.-P., Rozenbaum, M., Rosner, I., Guye, M., Bernard, M. and Bendahan, D. (2015) “Standardized quantitative measurements of wrist cartilage in healthy humans using 3T magnetic resonance imaging,” World Journal of Orthopedics, 6(8), pp. 641–648. Available at: https://doi.org/10.5312/wjo.v6.i8.641.
Wegrzyk, J., Foure, A., Vilmen, C., Ghattas, B., Maffiuletti, N.A., Mattei, J.-P., Place, N., Bendahan, D. and Gondin, J. (2015) “Extra Forces induced by wide-pulse, high-frequency electrical stimulation: Occurrence, magnitude, variability and underlying mechanisms,” Clinical Neurophysiology, 126(7), pp. 1400–1412. Available at: https://doi.org/10.1016/j.clinph.2014.10.001.
Fouré, A., Wegrzyk, J., LE Fur, Y., Mattei, J.-P., Boudinet, H., Vilmen, C., Bendahan, D. and Gondin, J. (2015) “Impaired mitochondrial function and reduced energy cost as a result of muscle damage,” Medicine and Science in Sports and Exercise, 47(6), pp. 1135–1144. Available at: https://doi.org/10.1249/MSS.0000000000000523.
Jubeau, M., LE Fur, Y., Duhamel, G., Wegrzyk, J., Confort-Gouny, S., Vilmen, C., Cozzone, P.J., Mattei, J.P., Bendahan, D. and Gondin, J. (2015) “Localized metabolic and t2 changes induced by voluntary and evoked contractions,” Medicine and Science in Sports and Exercise, 47(5), pp. 921–930. Available at: https://doi.org/10.1249/MSS.0000000000000491.
Fouré, A., Duhamel, G., Wegrzyk, J., Boudinet, H., Mattei, J.-P., Le Troter, A., Bendahan, D. and Gondin, J. (2015) “Heterogeneity of muscle damage induced by electrostimulation: a multimodal MRI study,” Medicine and Science in Sports and Exercise, 47(1), pp. 166–175. Available at: https://doi.org/10.1249/MSS.0000000000000397.
Wegrzyk, J., Fouré, A., Le Fur, Y., Maffiuletti, N.A., Vilmen, C., Guye, M., Mattei, J.-P., Place, N., Bendahan, D. and Gondin, J. (2015) “Responders to Wide-Pulse, High-Frequency Neuromuscular Electrical Stimulation Show Reduced Metabolic Demand: A 31P-MRS Study in Humans,” PloS One, 10(11), p. e0143972. Available at: https://doi.org/10.1371/journal.pone.0143972.
Silvy, F., Bertin, D., Bardin, N., Auger, I., Guzian, M.-C., Mattei, J.-P., Guis, S., Roudier, J. and Balandraud, N. (2015) “Antinuclear Antibodies in Patients with Psoriatic Arthritis Treated or Not with Biologics,” PloS One, 10(7), p. e0134218. Available at: https://doi.org/10.1371/journal.pone.0134218.
Fouré, A., Le Troter, A., Guye, M., Mattei, J.-P., Bendahan, D. and Gondin, J. (2015) “Localization and quantification of intramuscular damage using statistical parametric mapping and skeletal muscle parcellation,” Scientific Reports, 5, p. 18580. Available at: https://doi.org/10.1038/srep18580.
Fouré, A., Nosaka, K., Wegrzyk, J., Duhamel, G., Le Troter, A., Boudinet, H., Mattei, J.-P., Vilmen, C., Jubeau, M., Bendahan, D. and Gondin, J. (2014) “Time course of central and peripheral alterations after isometric neuromuscular electrical stimulation-induced muscle damage,” PloS One, 9(9), p. e107298. Available at: https://doi.org/10.1371/journal.pone.0107298.
Zink, J., Souteyrand, P., Guis, S., Chagnaud, C., Le Fur, Y., Militianu, D., Mattei, J.P., Rozenbaum, M., Rosner, I., Boudinet, H., Bernard, M. and Bendahan, D. (2013) “Semi-Automatic Quantitative Investigation of Wrist Cartilage in Humans Using 3t Mri,” Annals of the Rheumatic Diseases, 72, pp. 1018–1019.
Guis, S., Mattei, J.-P. and Bendahan, D. (2013) “Toxic myopathies,” Joint, bone, spine: revue du rhumatisme, 80(3), pp. 231–233. Available at: https://doi.org/10.1016/j.jbspin.2012.10.008.
Cammilleri, S., Guzian, M.C., Mattei, J.-P., Mundler, O. and Guis, S. (2013) “Whole-Body (18) FDG-PET in an Arthritis Paraneoplastic Syndrome Revealed an Underlying Hematological Neoplasm,” Case Reports in Medicine, 2013, p. 594704. Available at: https://doi.org/10.1155/2013/594704.
Guis, S., Schiano de Colella, J.-M., Bonnet, N., Andrac-Meyer, L., Balandraud, N., Mattei, J.-P., Franck, B., Roudier, C., Roudier, J. and Berbis, P. (2008) “Cutaneous pseudolymphoma associated with a TNF-alpha inhibitor treatment: etanercept,” European journal of dermatology: EJD, 18(4), pp. 474–476. Available at: https://doi.org/10.1684/ejd.2008.0457.
Guis, S., Balandraud, N., Bouvenot, J., Auger, I., Toussirot, E., Wendling, D., Mattei, J.-P., Nogueira, L., Mugnier, B., Legeron, P., Landt, O., Serre, G., Roudier, J. and Roudier, C. (2007) “Influence of -308 A/G polymorphism in the tumor necrosis factor alpha gene on etanercept treatment in rheumatoid arthritis,” Arthritis and Rheumatism, 57(8), pp. 1426–1430. Available at: https://doi.org/10.1002/art.23092.
Charpin, C., Berbis, P., Schmitz, J., Boudinet, H., Mattei, J.-P., Balandraud, N., Chagnaud, C., Roudier, J. and Guis, S. (2007) “Neurofibromatosis type 1 with sciatica,” Joint, Bone, Spine: Revue Du Rhumatisme, 74(3), pp. 300–301. Available at: https://doi.org/10.1016/j.jbspin.2006.09.013.
Mattei, J.P., Fur, Y.L., Cuge, N., Guis, S., Cozzone, P.J. and Bendahan, D. (2006) “Segmentation of fascias, fat and muscle from magnetic resonance images in humans: the DISPIMAG software,” Magma (New York, N.Y.), 19(5), pp. 275–279. Available at: https://doi.org/10.1007/s10334-006-0051-1.
Guis, S., Figarella-Branger, D., Mattei, J.P., Nicoli, F., Le Fur, Y., Kozak-Ribbens, G., Pellissier, J.F., Cozzone, P.J., Amabile, N. and Bendahan, D. (2006) “In vivo and in vitro characterization of skeletal muscle metabolism in patients with statin-induced adverse effects,” Arthritis and rheumatism, 55(4), pp. 551–557. Available at: https://doi.org/10.1002/art.22100.
Bendahan, D., Mattei, J.P., Guis, S., Kozak-Ribbens, G. and Cozzone, P.J. (2006) “[Non-invasive investigation of muscle function using 31P magnetic resonance spectroscopy and 1H MR imaging],” Revue neurologique, 162(4), pp. 467–484.
Alcaraz, P., Aubran, C., Jaoua, S., Roudier, C., Mattei, J.P., Announ, N., Chagnaud, C., Roudier, J. and Guis, S. (2006) “Calcaneal osteomyelitis due to fistulization of an ulcerated rheumatoid nodule,” Joint, Bone, Spine: Revue Du Rhumatisme, 73(1), pp. 102–104. Available at: https://doi.org/10.1016/j.jbspin.2005.01.006.
Guis, S., Mattei, J.-P., Cozzone, P.J. and Bendahan, D. (2005) “Pathophysiology and clinical presentations of rhabdomyolysis,” Joint, bone, spine: revue du rhumatisme, 72(5), pp. 382–391. Available at: https://doi.org/10.1016/j.jbspin.2004.04.010.
Guis, S., Mattei, J.-P., Pellissier, J.-F., Nicoli, F., Figarella-Branger, D., Le Fur, Y., Kaplanski, G., Pelletier, J., Harle, J.-R., Cozzone, P.J. and Bendahan, D. (2004) “MRI and 31PMR spectroscopy investigations of muscle function disclose no abnormality in macrophagic myofasciitis,” The Journal of rheumatology, 31(11), pp. 2313–2314.
Bendahan, D., Guis, S., Monnier, N., Kozak-Ribbens, G., Lunardi, J., Ghattas, B., Mattei, J.-P. and Cozzone, P.J. (2004) “Comparative analysis of in vitro contracture tests with ryanodine and a combination of ryanodine with either halothane or caffeine: a comparative investigation in malignant hyperthermia,” Acta anaesthesiologica Scandinavica, 48(8), pp. 1019–1027. Available at: https://doi.org/10.1111/j.0001-5172.2004.00461.x.
Announ, N., Mattei, J.P., Jaoua, S., Fenollar, F., Sati, H., Chagnaud, C., Roudier, J. and Guis, S. (2004) “Multifocal discitis caused by Staphylococcus warneri,” Joint, Bone, Spine: Revue Du Rhumatisme, 71(3), pp. 240–242. Available at: https://doi.org/10.1016/S1297-319X(03)00126-X.
Mattei, J.P., Bendahan, D. and Cozzone, P. (2004) “P-31 magnetic resonance spectroscopy. A tool for diagnostic purposes and pathophysiological insights in muscle diseases,” Reumatismo, 56(1), pp. 9–14.
Guis, S., Figarella-Branger, D., Monnier, N., Bendahan, D., Kozak-Ribbens, G., Mattei, J.-P., Lunardi, J., Cozzone, P.J. and Pellissier, J.-F. (2004) “Multiminicore disease in a family susceptible to malignant hyperthermia: histology, in vitro contracture tests, and genetic characterization,” Archives of neurology, 61(1), pp. 106–113. Available at: https://doi.org/10.1001/archneur.61.1.106.
Guis, S., Bendahan, D., Kozak-Ribbens, G., Figarella-Branger, D., Mattei, J.P., Pellissier, J.F., Treffouret, S., Bernard, V., Lando, A. and Cozzone, P.J. (2003) “Rhabdomyolysis and myalgia associated with anticholesterolemic treatment as potential signs of malignant hyperthermia susceptibility,” Arthritis and rheumatism, 49(2), pp. 237–238. Available at: https://doi.org/10.1002/art.11013.
Roussel, M., Mattei, J.P., Le Fur, Y., Ghattas, B., Cozzone, P.J. and Bendahan, D. (2003) “Metabolic determinants of the onset of acidosis in exercising human muscle: a 31P-MRS study,” Journal of applied physiology (Bethesda, Md.: 1985), 94(3), pp. 1145–1152. Available at: https://doi.org/10.1152/japplphysiol.01024.2000.
Guis, S., Mattei, J.P., Nicoli, F., Pellissier, J.F., Kaplanski, G., Figarella-Branger, D., Manez, G.C., Antipoff, G.M. and Roudier, J. (2002) “Identical twins with macrophagic myofasciitis: genetic susceptibility and triggering by aluminic vaccine adjuvants?,” Arthritis and Rheumatism, 47(5), pp. 543–545. Available at: https://doi.org/10.1002/art.10666.
Guis, S., Pellissier, J.-F., Nicoli, F., Reviron, D., Mattei, J.-P., Gherardi, R.K., Pelletier, J., Kaplanski, G., Figarella-Branger, D. and Roudier, J. (2002) “HLA-DRB1*01 and macrophagic myofasciitis,” Arthritis and Rheumatism, 46(9), pp. 2535–2537. Available at: https://doi.org/10.1002/art.10465.
Bendahan, D., Mattei, J.P., Ghattas, B., Confort-Gouny, S., Le Guern, M.E. and Cozzone, P.J. (2002) “Citrulline/malate promotes aerobic energy production in human exercising muscle,” British journal of sports medicine, 36(4), pp. 282–289.
Mattei, J.-P., Kozak-Ribbens, G., Roussel, M., Le Fur, Y., Cozzone, P.J. and Bendahan, D. (2002) “New parameters reducing the interindividual variability of metabolic changes during muscle contraction in humans. A (31)P MRS study with physiological and clinical implications,” Biochimica et biophysica acta, 1554(1–2), pp. 129–136.
Guis, S., Bendahan, D., Kozak-Ribbens, G., Mattei, J.P., Le Fur, Y., Confort-Gouny, S., Figarella-Branger, D., Jouglard, J. and Cozzone, P.J. (2002) “Investigation of fluoroquinolone-induced myalgia using (31)P magnetic resonance spectroscopy and in vitro contracture tests,” Arthritis and rheumatism, 46(3), pp. 774–778. Available at: https://doi.org/10.1002/art.10094.
Camacho, M., Guis, S., Mattei, J.-P., Costello, R. and Roudier, J. (2002) “Three-year outcome in a patient with Staphylococcus lugdunensis discitis,” Joint, Bone, Spine: Revue Du Rhumatisme, 69(1), pp. 85–87.