LAN Carole

carole.lan@univ-amu.fr
Phone : +33491324808

Cardiovascular (CVS) imaging team.

Platform

Technician
at AP-HM

Technician in the Cardiovascular System team.

Detailed Activities

Research in the field of Magnetic Resonance Spectroscopy (MRS) applications to biological systems: heart disease in diabetes mellitus, heart failure and myocardial protection during long term preservation based on metabolic (using P-31 MRS) ,hemodynamic and biochemical evaluation (HPLC, western Blot…)

I perform all the MRS experiments on isolated perfused rat hearts. I am the biochemist of the group and I have a lot of expertise in biochemical assays such as HPLC, Western Blot or enzymatic assays. In parallel, I participe in the data analysis on cardiac energy metabolism, functional parameters and biochemical results.

Keywords

Energy metabolism
Heart
Heart Failure
Metabolism
Quantitative MRS

Endothelial dysfunction
Ischaemia-reperfusion injury
Long-term heart preservation
Nitric oxide (NO) pathway
Type 2 diabetic heart

General Information

Collaborations :
-UNIVERSITE PARIS-DIDEROT, CNRS EAC 4413, LABORATOIRE DE BIOLOGIE ET PATHOLOGIE DU PANCREAS ENDOCRINE (B2PE), UNITE BFA, PR J. MOVASSAT/ PR B. PORTHA.
-UNIVERSITE D’AVIGNON ET DES PAYS DE VAUCLUSE, LABORATOIRE PHYSIOLOGIE DES ADAPTATIONS CARDIOVASCULAIRES A L’EXERCICE, DR C. REBOUL.
-UNIVERSITE DE MONTPELLIER : INSERM U1046- CNRS UMR 9214, PHYMEDEXP, DR O. CAZORLA.

-UNIVERSITY LABORATORY OF PHYSIOLOGY, CARDIAC METABOLISM RESEARCH GROUP, OXFORD (UK) : PR. K. CLARKE.
-AIX-MARSEILLE UNIVERSITE, UMR1062 NORT NUTRITION, OBESITE ET RISQUE THROMBOTIQUE, DR E. SEREE.
-CHU D’AMIENS, DEPARTEMENT DE CHIRURGIE CARDIAQUE, PR. T. CAUS.

Publications :

180164 LAN 1 harvard-cite-them-right-no-et-al 50 date desc year 2612 https://crmbm.univ-amu.fr/wp-content/plugins/zotpress/

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Jouenne, A., Hamici, K., Varlet, I., Sourdon, J., Daudé, P., Lan, C., Kober, F., Landrier, J.F., Bernard, M. and Desrois, M. (2023) ‘Relationship of cardiac remodeling and perfusion alteration with hepatic lipid metabolism in a prediabetic high fat high sucrose diet female rat model’, Biochemical and Biophysical Research Communications, 682, pp. 207–215. Available at: https://doi.org/10.1016/j.bbrc.2023.09.089.

Fourny, N., Lan, C., Bernard, M. and Desrois, M. (2021) ‘Male and Female Rats Have Different Physiological Response to High-Fat High-Sucrose Diet but Similar Myocardial Sensitivity to Ischemia-Reperfusion Injury’, Nutrients, 13(9), p. 2914. Available at: https://doi.org/10.3390/nu13092914.

Dhumal, D., Lan, W., Ding, L., Jiang, Y., Lyu, Z., Laurini, E., Marson, D., Tintaru, A., Dusetti, N., Giorgio, S., Iovanna, J.L., Pricl, S. and Peng, L. (2021) ‘An ionizable supramolecular dendrimer nanosystem for effective siRNA delivery with a favorable safety profile’, Nano Research, 14(7), pp. 2247–2254. Available at: https://doi.org/10.1007/s12274-020-3216-8.