GUYE Maxime

maxime.guye@ap-hm.fr
Phone : +33491388464

CNS

Professor at AMU, MD, PhD

Director of the Centre for Magnetic Resonance in Biology and Medicine (CRMBM) at Aix-Marseille University (AMU) and director of the medical site of CRMBM at the University Hospital in Marseille, France.

Lead PI and coordinator of the “7T Aix-Marseille Initiative” project around the whole-body 7T MRI scanner hosted and operated by CRMBM.

Medical Doctor (MD)

Professor (MD, PhD)

Detailed Activities

Maxime Guye, M.D., Ph.D., is a Neurologist, Professor of Biophysics at the School of Medicine, Aix-Marseille University (AMU), and in the Medical Imaging Department of the Marseille University Hospital. He is director of the Centre for Magnetic Resonance in Biology and Medicine (CRMBM). After a fellowship in the UCL Epilepsy Imaging Group (London, UK), he started a research activity on epilepsy imaging using multimodal MRI and electrophysiology in Marseille in 2002. Since 2014 he is leading the 7T MRI facility in Marseille and is particularly involved in clinical research and applications of 7T MRI in neurological diseases.

He is actively involved in the MRI community at national and international level. He was elected to the ISMRM High Field Study Group committee and was a member of the ISMRM program committee. He has been elected President of the French Society for Magnetic Resonance in Biology & Medicine and a member of the scientific committee of the French Society of Radiology. He is also a member of the scientific committee of the French Society of Clinical Neurophysiology and of the French League Against Epilepsy.
Maxime has published over 190 peer-reviewed papers in the field of MRI and Neurology.
His research interests are: Ultra-high field MRI; combining and comparing multimodal MRI methods (fMRI, dMRI, MRSI, 23Na-MRI) with electrophysiological recordings ((ic)EEG, EEG/fMRI); and brain connectivity.

Keywords

  • Brain Connectivity
  • Ultra-high field MRI

Research Projects

Publications :

Testud, B., Destruel, A., Troalen, T., Ranjeva, J.-P. and Guye, M. (2025) ‘Review of 7T MRI imaging of pituitary microadenomas: are we there yet?’, Neuroradiology [Preprint]. Available at: https://doi.org/10.1007/s00234-025-03554-9.
Licht, C., Ilicak, E., Boada, F.E., Guye, M., Zöllner, F.G., Schad, L.R. and Rapacchi, S. (2025) ‘A noise-robust post-processing pipeline for accelerated phase-cycled 23Na Multi-Quantum Coherences MRI’, Zeitschrift Fur Medizinische Physik, pp. S0939-3889(24)00117-X. Available at: https://doi.org/10.1016/j.zemedi.2024.12.004.
Martin, S., André, R., Trabelsi, A., Michel, C.P., Fortanier, E., Attarian, S., Guye, M., Dubois, M., Abdeddaim, R. and Bendahan, D. (2025) ‘Importance of neural network complexity for the automatic segmentation of individual thigh muscles in MRI images from patients with neuromuscular diseases’, Magma (New York, N.Y.) [Preprint]. Available at: https://doi.org/10.1007/s10334-024-01221-3.
Fortanier, E., Michel, C.P., Hostin, M.A., Delmont, E., Verschueren, A., Guye, M., Bellemare, M.-E., Bendahan, D. and Attarian, S. (2025) ‘Quantitative muscle MRI combined with AI-based segmentation as a follow-up biomarker for ATTRv patients: A longitudinal pilot study’, European Journal of Neurology, 32(1), p. e16574. Available at: https://doi.org/10.1111/ene.16574.
Grapperon, A.-M., El Mendili, M.M., Maarouf, A., Ranjeva, J.-P., Guye, M., Verschueren, A., Attarian, S. and Zaaraoui, W. (2025) ‘In vivo mapping of sodium homeostasis disturbances in individual ALS patients: A brain 23Na MRI study’, PloS One, 20(1), p. e0316916. Available at: https://doi.org/10.1371/journal.pone.0316916.
Testud, B., Guye, M., Witjas, T. and Grimaldi, S. (2024) ‘Iron overload revealing the cytoarchitecture of the red nucleus: A case study’, Revue Neurologique, pp. S0035-3787(24)00660-X. Available at: https://doi.org/10.1016/j.neurol.2024.11.001.
Joppin, V., Jourdan, A., Bendahan, D., Soucasse, A., Guye, M., Masson, C. and Bège, T. (2024) ‘Towards a better understanding of abdominal wall biomechanics: In vivo relationship between dynamic intra-abdominal pressure and magnetic resonance imaging measurements’, Clinical Biomechanics (Bristol, Avon), 121, p. 106396. Available at: https://doi.org/10.1016/j.clinbiomech.2024.106396.
Durozard, P., Maarouf, A., Zaaraoui, W., Stellmann, J.-P., Boutière, C., Rico, A., Demortière, S., Guye, M., Le Troter, A., Dary, H., Ranjeva, J.-P., Audoin, B. and Pelletier, J. (2024) ‘Cortical Lesions as an Early Hallmark of Multiple Sclerosis: Visualization by 7 T MRI’, Investigative Radiology, 59(11), p. 747. Available at: https://doi.org/10.1097/RLI.0000000000001082.
Soustelle, L., Mchinda, S., Hertanu, A., Gherib, S., Pini, L., Guye, M., Ranjeva, J.-P., Varma, G., Alsop, D.C., Pelletier, J., Girard, O.M. and Duhamel, G. (2024) ‘Inhomogeneous magnetization transfer (ihMT) imaging reveals variable recovery profiles of active MS lesions according to size and localization’, Imaging Neuroscience, 2, pp. 1–20. Available at: https://doi.org/10.1162/imag_a_00235.
Köksal-Ersöz, E., Makhalova, J., Yochum, M., Bénar, C.-G., Guye, M., Bartolomei, F., Wendling, F. and Merlet, I. (2024) ‘Whole-brain simulation of interictal epileptic discharges for patient-specific interpretation of interictal SEEG data’, Neurophysiologie Clinique = Clinical Neurophysiology, 54(5), p. 103005. Available at: https://doi.org/10.1016/j.neucli.2024.103005.
Grimaldi, S., Le Troter, A., El Mendili, M.M., Dary, H., Azulay, J.-P., Zaaraoui, W., Ranjeva, J.-P., Eusebio, A., de Rochefort, L. and Guye, M. (2024) ‘Energetic dysfunction and iron overload in early Parkinson’s disease: Two distinct mechanisms?’, Parkinsonism & Related Disorders, 124, p. 106996. Available at: https://doi.org/10.1016/j.parkreldis.2024.106996.
Tilsley, P., Moutiez, A., Brodovitch, A., Mendili, M.M.E., Testud, B., Zaaraoui, W., Verschueren, A., Attarian, S., Guye, M., Boucraut, J., Grapperon, A.-M. and Stellmann, J.-P. (2024) ‘Neurofilament Light Chain Levels Interact with Neurodegenerative Patterns and Motor Neuron Dysfunction in Amyotrophic Lateral Sclerosis’, American Journal of Neuroradiology, 45(4), pp. 494–503. Available at: https://doi.org/10.3174/ajnr.A8154.
Testud, B., Carle, X., Costes, C., Hak, J.-F. and Guye, M. (2024) ‘Added Value of Ultrahigh-Resolution 7T MRI in Dural Arteriovenous Fistulas’, Stroke, 55(3), pp. e46–e47. Available at: https://doi.org/10.1161/STROKEAHA.123.045930.
Licht, C., Reichert, S., Bydder, M., Zapp, J., Corella, S., Guye, M., Zöllner, F.G., Schad, L.R. and Rapacchi, S. (2024) ‘Low-rank reconstruction for simultaneous double half-echo 23Na and undersampled 23Na multi-quantum coherences MRI’, Magnetic Resonance in Medicine, 92(4), pp. 1440–1455. Available at: https://doi.org/10.1002/mrm.30132.
Licht, C., Reichert, S., Guye, M., Schad, L.R. and Rapacchi, S. (2024) ‘Multidimensional compressed sensing to advance 23Na multi-quantum coherences MRI’, Magnetic Resonance in Medicine, 91(3), pp. 926–941. Available at: https://doi.org/10.1002/mrm.29902.
Azilinon, M., Wang, H.E., Makhalova, J., Zaaraoui, W., Ranjeva, J.-P., Bartolomei, F., Guye, M. and Jirsa, V. (2024) ‘Brain sodium MRI-derived priors support the estimation of epileptogenic zones using personalized model-based methods in epilepsy’, Network Neuroscience (Cambridge, Mass.), 8(3), pp. 673–696. Available at: https://doi.org/10.1162/netn_a_00371.
Wirsich, J., Iannotti, G.R., Ridley, B., Shamshiri, E.A., Sheybani, L., Grouiller, F., Bartolomei, F., Seeck, M., Lazeyras, F., Ranjeva, J.-P., Guye, M. and Vulliemoz, S. (2024) ‘Altered correlation of concurrently recorded EEG-fMRI connectomes in temporal lobe epilepsy’, Network Neuroscience (Cambridge, Mass.), 8(2), pp. 466–485. Available at: https://doi.org/10.1162/netn_a_00362.
Daudé, P., Roussel, T., Troalen, T., Viout, P., Hernando, D., Guye, M., Kober, F., Confort Gouny, S., Bernard, M. and Rapacchi, S. (2024) ‘Comparative review of algorithms and methods for chemical-shift-encoded quantitative fat-water imaging’, Magnetic Resonance in Medicine, 91(2), pp. 741–759. Available at: https://doi.org/10.1002/mrm.29860.
El Mendili, M.M., Verschueren, A., Ranjeva, J.-P., Guye, M., Attarian, S., Zaaraoui, W. and Grapperon, A.-M. (2023) ‘Association between brain and upper cervical spinal cord atrophy assessed by MRI and disease aggressiveness in amyotrophic lateral sclerosis’, Neuroradiology, 65(9), pp. 1395–1403. Available at: https://doi.org/10.1007/s00234-023-03191-0.
Testud, B., Fabiani, N., Demortière, S., Mchinda, S., Medina, N.L., Pelletier, J., Guye, M., Audoin, B., Stellmann, J.P. and Callot, V. (2023) ‘Contribution of the MP2RAGE 7T Sequence in MS Lesions of the Cervical Spinal Cord’, AJNR. American journal of neuroradiology, 44(9), pp. 1101–1107. Available at: https://doi.org/10.3174/ajnr.A7964.
Soustelle, L., Troalen, T., Hertanu, A., Ranjeva, J.-P., Guye, M., Varma, G., Alsop, D.C., Duhamel, G. and Girard, O.M. (2023) ‘Quantitative magnetization transfer MRI unbiased by on-resonance saturation and dipolar order contributions’, Magnetic Resonance in Medicine, 90(3), pp. 875–893. Available at: https://doi.org/10.1002/mrm.29678.
Guenoun, D., Wirth, T., Roche, D., Michel, C.P., Daudé, P., Ogier, A.C., Chagnaud, C., Mattei, J.P., Pini, L., Guye, M., Ollivier, M., Bendahan, D. and Guis, S. (2023) ‘Ultra-high field magnetic resonance imaging of the quadriceps tendon enthesis in healthy subjects’, Surgical and Radiologic Anatomy, 45(8), pp. 1049–1054. Available at: https://doi.org/10.1007/s00276-023-03175-y.
Lee, H.M., Hong, S.-J., Gill, R., Caldairou, B., Wang, I., Zhang, J., Deleo, F., Schrader, D., Bartolomei, F., Guye, M., Cho, K.H., Barba, C., Sisodiya, S., Jackson, G., Hogan, R.E., Wong-Kisiel, L., Cascino, G.D., Schulze-Bonhage, A., Lopes-Cendes, I., Cendes, F., Guerrini, R., Bernhardt, B., Bernasconi, N. and Bernasconi, A. (2023) ‘Multimodal mapping of regional brain vulnerability to focal cortical dysplasia’, Brain, 146(8), pp. 3404–3415. Available at: https://doi.org/10.1093/brain/awad060.
Graber, M., Cadour, F., El Ahmadi, A.A., Khati, I., Del Grande, J., Chagnaud, C., Fakhry, N., Guye, M. and Varoquaux, A. (2023) ‘Adding automated decision-tree models to multiparametric MRI for parotid tumours improves clinical performance’, European Journal of Radiology, 166, p. 110999. Available at: https://doi.org/10.1016/j.ejrad.2023.110999.
Cadour, F., Quemeneur, M., Biere, L., Donal, E., Bentatou, Z., Eicher, J.-C., Roubille, F., Lalande, A., Giorgi, R., Rapacchi, S., Cortaredona, S., Tradi, F., Bartoli, A., Willoteaux, S., Delahaye, F., Biene, S.M., Mangin, L., Ferrier, N., Dacher, J.-N., Bauer, F., Leurent, G., Lentz, P.-A., Kovacsik, H., Croisille, P., Thuny, F., Bernard, M., Guye, M., Furber, A., Habib, G. and Jacquier, A. (2023) ‘Prognostic value of cardiovascular magnetic resonance T1 mapping and extracellular volume fraction in nonischemic dilated cardiomyopathy’, Journal of Cardiovascular Magnetic Resonance: Official Journal of the Society for Cardiovascular Magnetic Resonance, 25(1), p. 7. Available at: https://doi.org/10.1186/s12968-023-00919-y.
Wang, H.E., Woodman, M., Triebkorn, P., Lemarechal, J.-D., Jha, J., Dollomaja, B., Vattikonda, A.N., Sip, V., Medina Villalon, S., Hashemi, M., Guye, M., Makhalova, J., Bartolomei, F. and Jirsa, V. (2023) ‘Delineating epileptogenic networks using brain imaging data and personalized modeling in drug-resistant epilepsy’, Science Translational Medicine, 15(680), p. eabp8982. Available at: https://doi.org/10.1126/scitranslmed.abp8982.
Hostin, M.-A., Ogier, A.C., Michel, C.P., Le Fur, Y., Guye, M., Attarian, S., Fortanier, E., Bellemare, M.-E. and Bendahan, D. (2023) ‘The Impact of Fatty Infiltration on MRI Segmentation of Lower Limb Muscles in Neuromuscular Diseases: A Comparative Study of Deep Learning Approaches’, Journal of Magnetic Resonance Imaging, 58(6), pp. 1826–1835. Available at: https://doi.org/10.1002/jmri.28708.
Haast, R.A.M., Testud, B., Makhalova, J., Dary, H., Cabane, A., Le Troter, A., Ranjeva, J.-P., Bartolomei, F. and Guye, M. (2023) ‘Multi-scale structural alterations of the thalamus and basal ganglia in focal epilepsy using 7T MRI’, Human Brain Mapping, 44(13), pp. 4754–4771. Available at: https://doi.org/10.1002/hbm.26414.
Azilinon, M., Makhalova, J., Zaaraoui, W., Medina Villalon, S., Viout, P., Roussel, T., El Mendili, M.M., Ridley, B., Ranjeva, J.-P., Bartolomei, F., Jirsa, V. and Guye, M. (2023) ‘Combining sodium MRI, proton MR spectroscopic imaging, and intracerebral EEG in epilepsy’, Human Brain Mapping, 44(2), pp. 825–840. Available at: https://doi.org/10.1002/hbm.26102.
Destruel, A., Mauconduit, F., Massire, A., Abdeddaim, R., Guye, M., Gras, V. and Callot, V. (2023) ‘Optimized interferometric encoding of presaturated TurboFLASH B1 mapping for parallel transmission MRI at 7 T: Preliminary application for quantitative T1 mapping in the spinal cord’, Magnetic Resonance in Medicine, 90(4), pp. 1328–1344. Available at: https://doi.org/10.1002/mrm.29708.
Scholly, J., Gras, A., Guye, M., Bilger, M., Valenti Hirsch, M.P., Hirsch, E., Timofeev, A., Vidailhet, P., Bénar, C.G. and Bartolomei, F. (2022) ‘Connectivity Alterations in Emotional and Cognitive Networks During a Manic State Induced by Direct Electrical Stimulation’, Brain Topography, 35(5), pp. 627–635. Available at: https://doi.org/10.1007/s10548-022-00913-0.
Maarouf, A., Audoin, B., Gherib, S., El Mendili, M.M., Viout, P., Pariollaud, F., Boutière, C., Rico, A., Guye, M., Ranjeva, J.-P., Zaaraoui, W. and Pelletier, J. (2022) ‘Grey-matter sodium concentration as an individual marker of multiple sclerosis severity’, Multiple Sclerosis Journal, 28(12), pp. 1903–1912. Available at: https://doi.org/10.1177/13524585221102587.
Forodighasemabadi, A., Baucher, G., Soustelle, L., Troalen, T., Girard, O.M., Guye, M., Grisoli, J.-B., Ranjeva, J.-P., Duhamel, G. and Callot, V. (2022) ‘Spinal cord and brain tissue impairments as long-term effects of rugby practice? An exploratory study based on T1 and ihMTsat measures’, NeuroImage. Clinical, 35, p. 103124. Available at: https://doi.org/10.1016/j.nicl.2022.103124.
Sip, V., Guye, M., Bartolomei, F. and Jirsa, V. (2022) ‘Computational modeling of seizure spread on a cortical surface’, Journal of Computational Neuroscience, 50(1), pp. 17–31. Available at: https://doi.org/10.1007/s10827-021-00802-8.
Jourdan, A., Rapacchi, S., Guye, M., Bendahan, D., Masson, C. and Bège, T. (2022) ‘Dynamic-MRI quantification of abdominal wall motion and deformation during breathing and muscular contraction’, Computer Methods and Programs in Biomedicine, 217, p. 106667. Available at: https://doi.org/10.1016/j.cmpb.2022.106667.
El Mendili, M.M., Grapperon, A.-M., Dintrich, R., Stellmann, J.-P., Ranjeva, J.-P., Guye, M., Verschueren, A., Attarian, S. and Zaaraoui, W. (2022) ‘Alterations of Microstructure and Sodium Homeostasis in Fast Amyotrophic Lateral Sclerosis Progressors: A Brain DTI and Sodium MRI Study’, American Journal of Neuroradiology, 43(7), pp. 984–990. Available at: https://doi.org/10.3174/ajnr.A7559.
Brun, G., Testud, B., Girard, O.M., Lehmann, P., de Rochefort, L., Besson, P., Massire, A., Ridley, B., Girard, N., Guye, M., Ranjeva, J.-P. and Le Troter, A. (2022) ‘Automatic segmentation of deep grey nuclei using a high-resolution 7T magnetic resonance imaging atlas—Quantification of T1 values in healthy volunteers’, European Journal of Neuroscience, 55(2), pp. 438–460. Available at: https://doi.org/10.1111/ejn.15575.
Makhalova, J., Medina Villalon, S., Wang, H., Giusiano, B., Woodman, M., Bénar, C., Guye, M., Jirsa, V. and Bartolomei, F. (2022) ‘Virtual epileptic patient brain modeling: Relationships with seizure onset and surgical outcome’, Epilepsia, 63(8), pp. 1942–1955. Available at: https://doi.org/10.1111/epi.17310.
Roussel, T., Le Fur, Y., Guye, M., Viout, P., Ranjeva, J.-P. and Callot, V. (2022) ‘Respiratory-triggered quantitative MR spectroscopy of the human cervical spinal cord at 7 T’, Magnetic Resonance in Medicine, 87(6), pp. 2600–2612. Available at: https://doi.org/10.1002/mrm.29182.
Soustelle, L., Troalen, T., Hertanu, A., Mchinda, S., Ranjeva, J.-P., Guye, M., Varma, G., Alsop, D.C., Duhamel, G. and Girard, O.M. (2022) ‘A strategy to reduce the sensitivity of inhomogeneous magnetization transfer (ihMT) imaging to radiofrequency transmit field variations at 3 T’, Magnetic Resonance in Medicine, 87(3), pp. 1346–1359. Available at: https://doi.org/10.1002/mrm.29055.
Forodighasemabadi, A., Rasoanandrianina, H., El Mendili, M.M., Guye, M. and Callot, V. (2021) ‘An optimized MP2RAGE sequence for studying both brain and cervical spinal cord in a single acquisition at 3T’, Magnetic Resonance Imaging, 84, pp. 18–26. Available at: https://doi.org/10.1016/j.mri.2021.08.011.
Makhalova, J., Le Troter, A., Aubert-Conil, S., Giusiano, B., McGonigal, A., Trebuchon, A., Carron, R., Medina Villalon, S., Bénar, C.G., Ranjeva, J.-P., Guye, M. and Bartolomei, F. (2021) ‘Epileptogenic networks in drug-resistant epilepsy with amygdala enlargement: Assessment with stereo-EEG and 7 T MRI’, Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology, 133, pp. 94–103. Available at: https://doi.org/10.1016/j.clinph.2021.10.012.
Gill, R.S., Lee, H.-M., Caldairou, B., Hong, S.-J., Barba, C., Deleo, F., D’Incerti, L., Coelho, V.C.M., Lenge, M., Semmelroch, M., Schrader, D.V., Bartolomei, F., Guye, M., Schulze-Bonhage, A., Urbach, H., Cho, K.H., Cendes, F., Guerrini, R., Jackson, G., Hogan, R.E., Bernasconi, N. and Bernasconi, A. (2021) ‘Multicenter Validation of a Deep Learning Detection Algorithm for Focal Cortical Dysplasia’, Neurology, 97(16), pp. e1571–e1582. Available at: https://doi.org/10.1212/WNL.0000000000012698.
Fournel, J., Bartoli, A., Bendahan, D., Guye, M., Bernard, M., Rauseo, E., Khanji, M.Y., Petersen, S.E., Jacquier, A. and Ghattas, B. (2021) ‘Medical image segmentation automatic quality control: A multi-dimensional approach’, Medical Image Analysis, 74, p. 102213. Available at: https://doi.org/10.1016/j.media.2021.102213.
Hashemi, M., Vattikonda, A.N., Sip, V., Diaz-Pier, S., Peyser, A., Wang, H., Guye, M., Bartolomei, F., Woodman, M.M. and Jirsa, V.K. (2021) ‘On the influence of prior information evaluated by fully Bayesian criteria in a personalized whole-brain model of epilepsy spread’, PLoS computational biology, 17(7), p. e1009129. Available at: https://doi.org/10.1371/journal.pcbi.1009129.
Callot, V., Massire, A., Guye, M., Attarian, S. and Verschueren, A. (2021) ‘Visualization of Gray Matter Atrophy and Anterior Corticospinal Tract Signal Hyperintensity in Amyotrophic Lateral Sclerosis Using 7T MRI’, Neurology, 96(23), pp. 1094–1095. Available at: https://doi.org/10.1212/WNL.0000000000012072.
Sourdon, J., Roussel, T., Costes, C., Viout, P., Guye, M., Ranjeva, J.-P., Bernard, M., Kober, F. and Rapacchi, S. (2021) ‘Comparison of single-voxel 1H-cardiovascular magnetic resonance spectroscopy techniques for in vivo measurement of myocardial creatine and triglycerides at 3T’, Journal of Cardiovascular Magnetic Resonance: Official Journal of the Society for Cardiovascular Magnetic Resonance, 23(1), p. 53. Available at: https://doi.org/10.1186/s12968-021-00748-x.
Foussier, C., Barral, P.A., Jerosh-Herold, M., Gariboldi, V., Rapacchi, S., Gallon, A., Bartoli, A., Bentatou, Z., Guye, M., Bernard, M. and Jacquier, A. (2021) ‘Quantification of diffuse myocardial fibrosis using CMR extracellular volume fraction and serum biomarkers of collagen turnover with histologic quantification as standard of reference’, Diagnostic and Interventional Imaging, 102(3), pp. 163–169. Available at: https://doi.org/10.1016/j.diii.2020.07.005.