GUYE Maxime

Professor at AMU, MD, PhD

Deputy director of the Centre for Magnetic Resonance in Biology and Medicine (CRMBM) at Aix-Marseille University (AMU) and director of the medical site of CRMBM at the University Hospital in Marseille, France.

Lead PI and coordinator of the “7T Aix-Marseille Initiative” project around the whole-body 7T MRI scanner hosted and operated by CRMBM.

Medical Doctor (MD)

Professor (MD, PhD)

Detailed Activities

Professor of Biophysics at the AMU Faculty of Medicine and senior consultant in the Department of Clinical Neurophysiology of the University Hospital. He held a research position in Neuroimaging at University College of London, London, UK, after his residency in Marseille. He is a member of the Scientific Committee of: the French Society of Radiology; the French Society of Clinical Neurophysiology; the French League Against Epilepsy; and the French Foundation for Research against Epilepsy; He was elected member of the National Committee for Scientific Research (CNRS) (2008-2012) and President of the French Society for Magnetic Resonance in Biology and Medicine (2014-2016). Maxime has published over 120 peer-reviewed papers in the field of MRI and Neurology.
His research interests are: Ultra-high field MRI; combining and comparing multimodal MRI methods (fMRI, dMRI, MRSI, 23Na-MRI) with electrophysiological recordings ((ic)EEG, EEG/fMRI); and brain connectivity.


  • Brain Connectivity
  • Ultra-high field MRI

Publications :

Hostin, Marc-Adrien, Augustin C. Ogier, Constance Michel, Maxime Guye, and D Bendahan. “Geometric and Clinical Evaluation of Deep Learning-Based Segmentation of Individual Lower Limb Muscles from Patients with Neuropathies.” In International Society for Magnetic Resonance in Medicine, 531. London, n.d.
Guye, M, J L Gastaut, and F Bartolomei. “Epilepsy and Perisylvian Lipoma/Cortical Dysplasia Complex.” Epileptic Disorders: International Epilepsy Journal with Videotape 1, no. 1 (March 1999): 69–73.
Bartolomei, F, M Gavaret, C Dravet, M Guye, J Y Bally-Berard, P Genton, C Raybaud, J Régis, and J L Gastaut. “Late-Onset Epilepsy Associated with Regional Brain Cortical Dysplasia.” European Neurology 42, no. 1 (July 1999): 11–16.
Raybaud, C, M Guye, J Mancini, and N Girard. “Neuroimaging of Epilepsy in Children.” Magnetic Resonance Imaging Clinics of North America 9, no. 1 (February 2001): 121–47, viii.
Guye, M, F Bartolomei, J L Gastaut, P Chauvel, and C Dravet. “Absence Epilepsy with Fast Rhythmic Discharges during Sleep: An Intermediary Form of Generalized Epilepsy?” Epilepsia 42, no. 3 (March 2001): 351–56.
Bartolomei, F, M Guye, M Gavaret, J Régis, F Wendling, C Raybaud, and P Chauvel. “[The presurgical evaluation of epilepsies].” Revue neurologique 158, no. 5 Pt 2 (May 2002): 4S55-64.
Guye, Maxime, Yann Le Fur, Sylviane Confort-Gouny, Jean-Philippe Ranjeva, Fabrice Bartolomei, Jean Régis, Charles A Raybaud, Patrick Chauvel, and Patrick J Cozzone. “Metabolic and Electrophysiological Alterations in Subtypes of Temporal Lobe Epilepsy: A Combined Proton Magnetic Resonance Spectroscopic Imaging and Depth Electrodes Study.” Epilepsia 43, no. 10 (October 2002): 1197–1209.
Bartolomeil, Fabrice, Maxime Guye, Fabrice Wendling, Martine Gavaret, Jean Régis, and Patrick Chauvel. “Fear, Anger and Compulsive Behavior during Seizure: Involvement of Large Scale Fronto-Temporal Neural Networks.” Epileptic Disorders: International Epilepsy Journal with Videotape 4, no. 4 (December 2002): 235–41.
Guye, Maxime, Geoffrey J M Parker, Mark Symms, Philip Boulby, Claudia A M Wheeler-Kingshott, Afraim Salek-Haddadi, Gareth J Barker, and John S Duncan. “Combined Functional MRI and Tractography to Demonstrate the Connectivity of the Human Primary Motor Cortex in Vivo.” NeuroImage 19, no. 4 (August 2003): 1349–60.
Galanaud, D, F Nicoli, Y Le Fur, M Guye, J-P Ranjeva, S Confort-Gouny, P Viout, E Soulier, and P J Cozzone. “Multimodal Magnetic Resonance Imaging of the Central Nervous System.” Biochimie 85, no. 9 (September 2003): 905–14.
Powell, H W R, M Guye, G J M Parker, M R Symms, P Boulby, M J Koepp, Gareth J Barker, and J S Duncan. “Noninvasive in Vivo Demonstration of the Connections of the Human Parahippocampal Gyrus.” NeuroImage 22, no. 2 (June 2004): 740–47.
Bartolomei, F, E Barbeau, M Gavaret, M Guye, A McGonigal, J Régis, and P Chauvel. “Cortical Stimulation Study of the Role of Rhinal Cortex in Déjà vu and Reminiscence of Memories.” Neurology 63, no. 5 (September 14, 2004): 858–64.
Bartolomei, F, F Wendling, J Régis, M Gavaret, M Guye, and P Chauvel. “Pre-Ictal Synchronicity in Limbic Networks of Mesial Temporal Lobe Epilepsy.” Epilepsy Research 61, no. 1–3 (October 2004): 89–104.
Maillard, Louis, Jean-Pierre Vignal, Martine Gavaret, Maxime Guye, Arnaud Biraben, Aileen McGonigal, Patrick Chauvel, and Fabrice Bartolomei. “Semiologic and Electrophysiologic Correlations in Temporal Lobe Seizure Subtypes.” Epilepsia 45, no. 12 (December 2004): 1590–99.
Bartolomei, Fabrice, Mouhamad Khalil, Fabrice Wendling, Anna Sontheimer, Jean Régis, Jean-Phillipe Ranjeva, Maxime Guye, and Patrick Chauvel. “Entorhinal Cortex Involvement in Human Mesial Temporal Lobe Epilepsy: An Electrophysiologic and Volumetric Study.” Epilepsia 46, no. 5 (May 2005): 677–87.
Guye, M, J P Ranjeva, Y Le Fur, F Bartolomei, S Confort-Gouny, J Regis, P Chauvel, and P J Cozzone. “1H-MRS Imaging in Intractable Frontal Lobe Epilepsies Characterized by Depth Electrode Recording.” NeuroImage 26, no. 4 (July 15, 2005): 1174–83.
Jamali, Sarah, Fabrice Bartolomei, Andrée Robaglia-Schlupp, Annick Massacrier, Jean-Claude Peragut, Jean Régis, Henri Dufour, et al. “Large-Scale Expression Study of Human Mesial Temporal Lobe Epilepsy: Evidence for Dysregulation of the Neurotransmission and Complement Systems in the Entorhinal Cortex.” Brain: A Journal of Neurology 129, no. Pt 3 (March 2006): 625–41.
Guye, Maxime, Jean Régis, Manabu Tamura, Fabrice Wendling, Aileen McGonigal, Patrick Chauvel, and Fabrice Bartolomei. “The Role of Corticothalamic Coupling in Human Temporal Lobe Epilepsy.” Brain: A Journal of Neurology 129, no. Pt 7 (July 2006): 1917–28.
Guedj, Eric, Maxime Guye, Catherine de Laforte, Patrick Chauvel, Catherine Liegeois-Chauvel, Olivier Mundler, and Fabrice Bartolomei. “Neural Network Underlying Ictal Humming Demonstrated by Very Early SPECT: A Case Report.” Epilepsia 47, no. 11 (November 2006): 1968–70.
Guye, M, J P Ranjeva, F Bartolomei, S Confort-Gouny, A McGonigal, J Régis, P Chauvel, and P J Cozzone. “What Is the Significance of Interictal Water Diffusion Changes in Frontal Lobe Epilepsies?” NeuroImage 35, no. 1 (March 2007): 28–37.
Audoin, Bertrand, Maxime Guye, Françoise Reuter, My-Van Au Duong, Sylviane Confort-Gouny, Irina Malikova, Elisabeth Soulier, et al. “Structure of WM Bundles Constituting the Working Memory System in Early Multiple Sclerosis: A Quantitative DTI Tractography Study.” NeuroImage 36, no. 4 (July 15, 2007): 1324–30.
Bartolomei, F, A McGonigal, M Guye, E Guedj, and P Chauvel. “Clinical and Anatomic Characteristics of Humming and Singing in Partial Seizures.” Neurology 69, no. 5 (July 31, 2007): 490–92.
McGonigal, Aileen, Fabrice Bartolomei, Jean Régis, Maxime Guye, Martine Gavaret, Agnès Trébuchon-Da Fonseca, Henry Dufour, et al. “Stereoelectroencephalography in Presurgical Assessment of MRI-Negative Epilepsy.” Brain: A Journal of Neurology 130, no. Pt 12 (December 2007): 3169–83.
Valton, Luc, Maxime Guye, Aileen McGonigal, Patrick Marquis, Fabrice Wendling, Jean Régis, Patrick Chauvel, and Fabrice Bartolomei. “Functional Interactions in Brain Networks Underlying Epileptic Seizures in Bilateral Diffuse Periventricular Heterotopia.” Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology 119, no. 1 (January 2008): 212–23.
Khalfa, Stéphanie, Maxime Guye, Isabelle Peretz, Frédérique Chapon, Nadine Girard, Patrick Chauvel, and Catherine Liégeois-Chauvel. “Evidence of Lateralized Anteromedial Temporal Structures Involvement in Musical Emotion Processing.” Neuropsychologia 46, no. 10 (August 2008): 2485–93.
Guye, Maxime, Fabrice Bartolomei, and Jean-Philippe Ranjeva. “Imaging Structural and Functional Connectivity: Towards a Unified Definition of Human Brain Organization?” Current Opinion in Neurology 21, no. 4 (August 2008): 393–403.
Bettus, Gaelle, Fabrice Wendling, Maxime Guye, Luc Valton, Jean Régis, Patrick Chauvel, and Fabrice Bartolomei. “Enhanced EEG Functional Connectivity in Mesial Temporal Lobe Epilepsy.” Epilepsy Research 81, no. 1 (September 2008): 58–68.
McGonigal, Aileen, Martine Gavaret, Agnès Trébuchon Da Fonseca, Maxime Guye, Didier Scavarda, Nathalie Villeneuve, Jean Régis, Fabrice Bartolomei, and Patrick Chauvel. “MRI-Negative Prefrontal Epilepsy Due to Cortical Dysplasia Explored by Stereoelectroencephalography (SEEG).” Epileptic Disorders: International Epilepsy Journal with Videotape 10, no. 4 (December 2008): 330–38.
Vaudano, Anna E, Helmut Laufs, Stefan J Kiebel, David W Carmichael, Khalid Hamandi, Maxime Guye, Rachel Thornton, et al. “Causal Hierarchy within the Thalamo-Cortical Network in Spike and Wave Discharges.” PloS One 4, no. 8 (2009): e6475.
Tramoni, Eve, Stéphanie Aubert-Khalfa, Maxime Guye, Jean P Ranjeva, Olivier Felician, and Mathieu Ceccaldi. “Hypo-Retrieval and Hyper-Suppression Mechanisms in Functional Amnesia.” Neuropsychologia 47, no. 3 (February 2009): 611–24.
Felician, O, E Tramoni, E Barbeau, F Bartolomei, M Guye, M Poncet, and M Ceccaldi. “[Isolated autobiographical amnesia: a neurological basis?].” Revue neurologique 165, no. 5 (May 2009): 449–59.
Bettus, Gaelle, Eric Guedj, Florian Joyeux, Sylviane Confort-Gouny, Elisabeth Soulier, Virginie Laguitton, Patrick J Cozzone, et al. “Decreased Basal FMRI Functional Connectivity in Epileptogenic Networks and Contralateral Compensatory Mechanisms.” Human Brain Mapping 30, no. 5 (May 2009): 1580–91.
Vulliemoz, S, R Thornton, R Rodionov, D W Carmichael, M Guye, S Lhatoo, A W McEvoy, et al. “The Spatio-Temporal Mapping of Epileptic Networks: Combination of EEG-FMRI and EEG Source Imaging.” NeuroImage 46, no. 3 (July 1, 2009): 834–43.
Vaugier, L, S Aubert, A McGonigal, A Trébuchon, M Guye, M Gavaret, J Regis, P Chauvel, F Wendling, and F Bartolomei. “Neural Networks Underlying Hyperkinetic Seizures of ‘Temporal Lobe’ Origin.” Epilepsy Research 86, no. 2–3 (October 2009): 200–208.
Le Fur, Yann, François Nicoli, Maxime Guye, Sylviane Confort-Gouny, Patrick J Cozzone, and Frank Kober. “Grid-Free Interactive and Automated Data Processing for MR Chemical Shift Imaging Data.” Magnetic Resonance Materials in Physics, Biology and Medicine 23, no. 1 (February 2010): 23–30.
Vulliemoz, S, R Rodionov, D W Carmichael, R Thornton, M Guye, S D Lhatoo, C M Michel, J S Duncan, and L Lemieux. “Continuous EEG Source Imaging Enhances Analysis of EEG-FMRI in Focal Epilepsy.” NeuroImage 49, no. 4 (February 15, 2010): 3219–29.
Rodionov, Roman, Michael Siniatchkin, Christoph M Michel, Adam D Liston, Rachel Thornton, Maxime Guye, David W Carmichael, and Louis Lemieux. “Looking for Neuronal Currents Using MRI: An EEG-FMRI Investigation of Fast MR Signal Changes Time-Locked to Frequent Focal Epileptic Discharges.” NeuroImage 50, no. 3 (April 15, 2010): 1109–17.
Thornton, Rachel, Helmut Laufs, Roman Rodionov, Sajitha Cannadathu, David W Carmichael, Serge Vulliemoz, Afraim Salek-Haddadi, et al. “EEG Correlated Functional MRI and Postoperative Outcome in Focal Epilepsy.” Journal of Neurology, Neurosurgery, and Psychiatry 81, no. 8 (August 2010): 922–27.
Bettus, Gaelle, Fabrice Bartolomei, Sylviane Confort-Gouny, Eric Guedj, Patrick Chauvel, Patrick J Cozzone, Jean-Philippe Ranjeva, and Maxime Guye. “Role of Resting State Functional Connectivity MRI in Presurgical Investigation of Mesial Temporal Lobe Epilepsy.” Journal of Neurology, Neurosurgery, and Psychiatry 81, no. 10 (October 2010): 1147–54.
Thornton, R C, R Rodionov, H Laufs, S Vulliemoz, A Vaudano, D Carmichael, S Cannadathu, et al. “Imaging Haemodynamic Changes Related to Seizures: Comparison of EEG-Based General Linear Model, Independent Component Analysis of FMRI and Intracranial EEG.” NeuroImage 53, no. 1 (October 15, 2010): 196–205.
Guye, Maxime, Gaelle Bettus, Fabrice Bartolomei, and Patrick J Cozzone. “Graph Theoretical Analysis of Structural and Functional Connectivity MRI in Normal and Pathological Brain Networks.” Magma (New York, N.Y.) 23, no. 5–6 (December 2010): 409–21.
Guedj, E, E J Barbeau, C Liégeois-Chauvel, S Confort-Gouny, F Bartolomei, P Chauvel, P J Cozzone, J P Ranjeva, O Mundler, and M Guye. “Performance in Recognition Memory Is Correlated with Entorhinal/Perirhinal Interictal Metabolism in Temporal Lobe Epilepsy.” Epilepsy & Behavior: E&B 19, no. 4 (December 2010): 612–17.
Bettus, Gaelle, Jean-Philippe Ranjeva, Fabrice Wendling, Christian G Bénar, Sylviane Confort-Gouny, Jean Régis, Patrick Chauvel, et al. “Interictal Functional Connectivity of Human Epileptic Networks Assessed by Intracerebral EEG and BOLD Signal Fluctuations.” PloS One 6, no. 5 (2011): e20071.
Tramoni, Eve, Olivier Felician, Emmanuel J Barbeau, Eric Guedj, Maxime Guye, Fabrice Bartolomei, and Mathieu Ceccaldi. “Long-Term Consolidation of Declarative Memory: Insight from Temporal Lobe Epilepsy.” Brain: A Journal of Neurology 134, no. Pt 3 (March 2011): 816–31.
Guedj, Eric, Gaelle Bettus, Emmanuel J Barbeau, Catherine Liégeois-Chauvel, Sylviane Confort-Gouny, Fabrice Bartolomei, Patrick Chauvel, Patrick J Cozzone, Jean-Philippe Ranjeva, and Maxime Guye. “Hyperactivation of Parahippocampal Region and Fusiform Gyrus Associated with Successful Encoding in Medial Temporal Lobe Epilepsy.” Epilepsia 52, no. 6 (June 2011): 1100–1109.
Hewett, Russell, Maxime Guye, Martine Gavaret, and Fabrice Bartolomei. “Benign Temporo-Parieto-Occipital Junction Epilepsy with Vestibular Disturbance: An Underrecognized Form of Epilepsy?” Epilepsy & Behavior: E&B 21, no. 4 (August 2011): 412–16.
Gour, Natalina, Jean-Philippe Ranjeva, Mathieu Ceccaldi, Sylviane Confort-Gouny, Emmanuel Barbeau, Elisabeth Soulier, Maxime Guye, Mira Didic, and Olivier Felician. “Basal Functional Connectivity within the Anterior Temporal Network Is Associated with Performance on Declarative Memory Tasks.” NeuroImage 58, no. 2 (September 15, 2011): 687–97.
Thornton, Rachel, Serge Vulliemoz, Roman Rodionov, David W Carmichael, Umair J Chaudhary, Beate Diehl, Helmut Laufs, et al. “Epileptic Networks in Focal Cortical Dysplasia Revealed Using Electroencephalography-Functional Magnetic Resonance Imaging.” Annals of Neurology 70, no. 5 (November 2011): 822–37.