DESROIS Martine

martine.desrois@univ-amu.fr
Phone : +33491324808

Cardiovascular (CVS) imaging team.

Research Associate (PhD)

at CNRS

CNRS researcher in the team Cardiovascular System.

Research Associate (PhD)

Detailed Activities

My work concerns cardiovascular diseases associated with vascular endothelial dysfunction. The endothelium is an important regulator of coronary vascular tone due to its ability to release potent vasoactive substances such as the vasodilators nitric oxide (NO), endothelium-derived hyperpolarizing factor (EDHF), prostacyclin (PGI2) and the potent vasoconstrictor endothelin. Endothelial dysfunction has been associated with a number of cardiovascular diseases such as atherosclerosis, hypertension, diabetes mellitus, congestive heart failure and graft vasculopathy. A disturbance of endothelial function may also contribute to the adverse effects that ischaemia and reperfusion exerts on the coronary vasculature. Endothelial dysfunction is mainly caracterized by an impaired endothelium-dependent vasodilator responses to some agonists (ACh, ADP, …) and by a reduced release of nitric oxide (NO).

My current research interests is to study endothelial dysfunction involved in ischemia related to cardiac transplantation, in type 2 diabetic heart and heart failure. Pathological heart is assessed by a metabolic study using P-31 magnetic resonance spectroscopy combined to a functional evaluation and a measure of cellular integrity (biochemical assays, High Performance Liquid Chromatography (HPLC) and Western Blotting in cardiac tissues and effluents). In addition, magnetic resonance methods (spectrometry (MRS) and imaging (MRI)) combined to biochemical and molecular biology assays furnish morphological, physiological, functional and metabolic informations to characterize the pathological heart. Studies initially performed on the isolated perfused rat heart are extent to the in situ heart in animal and then, to the pathological human heart.

I am involved in collective tasks (Gaz, animal housing facility, students training, quality management).

Keywords

  • Energy metabolism
  • Heart
  • Quantitative MRS
  • Long-term heart preservation, Heart failure
  • Endothelial dysfunction
  • Ischaemia-reperfusion injury
  • Nitric oxide (NO) pathway
  • Type 2 diabetic heart

General Information

Collaborations :
-Université Paris-Diderot, CNRS EAC 4413, Laboratoire de Biologie et Pathologie du Pancréas Endocrine (B2PE), Unité BFA, Pr J. Movassat/ Pr B. Portha.
-Université d’Avignon et des Pays de Vaucluse, Laboratoire Physiologie des adaptations cardiovasculaires à l’exercice, Dr C. Reboul.
-UNIVERSITE DE MONTPELLIER : INSERM U1046- CNRS UMR 9214, PHYMEDEXP, DR O. CAZORLA.
-University Laboratory of Physiology, Cardiac Metabolism Research Group, Oxford (UK) : Pr. K. Clarke.
-Aix-Marseille Université, UMR1062 NORT Nutrition, Obésité et Risque Thrombotique, dr E. Sérée.
-CHU d’Amiens, Département de Chirurgie Cardiaque, Pr. T. Caus.

Teaching

In parallel to my scientific activity, I am also involved in teaching (Master 1 of Pathologies Humaines (Marseille) ; students training (Masters, pHD…), college students.

Grant Supports

-Programmes D’Actions Intégrées Alliance.
-ANR COFLORES ‘IMAGERIE DE LA RESERVE CORONAIRE SANS TRAÇEURS » 2014-2017 (participant).

Publications :

Jouenne, A., Hamici, K., Varlet, I., Sourdon, J., Daudé, P., Lan, C., Kober, F., Landrier, J.F., Bernard, M. and Desrois, M. (2023) ‘Relationship of cardiac remodeling and perfusion alteration with hepatic lipid metabolism in a prediabetic high fat high sucrose diet female rat model’, Biochemical and Biophysical Research Communications, 682, pp. 207–215. Available at: https://doi.org/10.1016/j.bbrc.2023.09.089.
Fourny, N., Lan, C., Bernard, M. and Desrois, M. (2021) ‘Male and Female Rats Have Different Physiological Response to High-Fat High-Sucrose Diet but Similar Myocardial Sensitivity to Ischemia-Reperfusion Injury’, Nutrients, 13(9), p. 2914. Available at: https://doi.org/10.3390/nu13092914.
Fourny, N., Beauloye, C., Bernard, M., Horman, S., Desrois, M. and Bertrand, L. (2021) ‘Sex Differences of the Diabetic Heart’, Frontiers in Physiology, 12, p. 661297. Available at: https://doi.org/10.3389/fphys.2021.661297.
Fourny, N., Lan, C., Kober, F., Boulghobra, D., Bresciani, J., Reboul, C., Bernard, M. and Desrois, M. (2019) ‘Cardiac remodeling and higher sensitivity to ischemia-reperfusion injury in female rats submitted to high-fat high-sucrose diet: An in vivo/ex vivo longitudinal follow-up’, The Journal of Nutritional Biochemistry, 69, pp. 139–150. Available at: https://doi.org/10.1016/j.jnutbio.2019.03.022.
Fourny, N., Lan, C., Sérée, E., Bernard, M. and Desrois, M. (2019) ‘Protective Effect of Resveratrol against Ischemia-Reperfusion Injury via Enhanced High Energy Compounds and eNOS-SIRT1 Expression in Type 2 Diabetic Female Rat Heart’, Nutrients, 11(1), p. E105. Available at: https://doi.org/10.3390/nu11010105.
Mathieu, C., Desrois, M., Kober, F., Lalevée, N., Lan, C., Fourny, N., Iché-Torres, M., Tran, T.T., Lê, L.T., Singer, M., Mège, J.-L., Bernard, M. and Leone, M. (2018) ‘Sex-Mediated Response to the Beta-Blocker Landiolol in Sepsis: An Experimental, Randomized Study’, Critical Care Medicine, 46(7), pp. e684–e691. Available at: https://doi.org/10.1097/CCM.0000000000003146.
Macia, M., Pecchi, E., Desrois, M., Lan, C., Vilmen, C., Portha, B., Bernard, M., Bendahan, D. and Giannesini, B. (2018) ‘Exercise training impacts exercise tolerance and bioenergetics in gastrocnemius muscle of non-obese type-2 diabetic Goto-Kakizaki rat in vivo’, Biochimie, 148, pp. 36–45. Available at: https://doi.org/10.1016/j.biochi.2018.02.014.
Desrois, M., Lan, C., Movassat, J. and Bernard, M. (2017) ‘Reduced up-regulation of the nitric oxide pathway and impaired endothelial and smooth muscle functions in the female type 2 diabetic goto-kakizaki rat heart’, Nutrition & Metabolism, 14, p. 6. Available at: https://doi.org/10.1186/s12986-016-0157-z.
Macia, M., Pecchi, E., Vilmen, C., Desrois, M., Lan, C., Portha, B., Bernard, M., Bendahan, D. and Giannesini, B. (2015) ‘Insulin Resistance Is Not Associated with an Impaired Mitochondrial Function in Contracting Gastrocnemius Muscle of Goto-Kakizaki Diabetic Rats In Vivo’, PloS One, 10(6), p. e0129579. Available at: https://doi.org/10.1371/journal.pone.0129579.
Desrois, M., Piccardo, A., Zogheib, E., Dalmasso, C., Lan, C., Fourré, D., Cozzone, P.J., Caus, T. and Bernard, M. (2014) ‘Heart donation after cardiac death: preliminary study on an isolated, perfused Swine heart after 20 minutes of normothermic ischemia’, Transplantation Proceedings, 46(10), pp. 3314–3318. Available at: https://doi.org/10.1016/j.transproceed.2014.04.021.
Desrois, M., Kober, F., Lan, C., Dalmasso, C., Cole, M., Clarke, K., Cozzone, P.J. and Bernard, M. (2014) ‘Effect of isoproterenol on myocardial perfusion, function, energy metabolism and nitric oxide pathway in the rat heart – a longitudinal MR study’, NMR in Biomedicine, 27(5), pp. 529–538. Available at: https://doi.org/10.1002/nbm.3088.
Desrois, M., Clarke, K., Lan, C., Dalmasso, C., Cole, M., Portha, B., Cozzone, P.J. and Bernard, M. (2010) ‘Upregulation of eNOS and unchanged energy metabolism in increased susceptibility of the aging type 2 diabetic GK rat heart to ischemic injury’, American Journal of Physiology - Heart and Circulatory Physiology, 299(5), pp. H1679–H1686. Available at: https://doi.org/10.1152/ajpheart.00998.2009.
Desrois, M., Caus, T., Dalmasso, C., Lan, C., Cozzone, P.J. and Bernard, M. (2009) ‘Expression of the three nitric oxide synthase isoforms and nitric oxide level in the rat heart during cold storage and blood reperfusion’, Cellular and molecular biology (Noisy-le-Grand, France), 55 Suppl, pp. OL1208-1214.
Desrois, M., Caus, T., Belles, P.M., Dalmasso, C., Lan, C., Cozzone, P.J. and Bernard, M. (2008) ‘Limitation of myocardial and endothelial injury of the rat heart graft after preservation with Centre de Résonance Magnétique Biologique et Médicale (CRMB) solution’, Transplant international: official journal of the European Society for Organ Transplantation, 21(3), pp. 276–283. Available at: https://doi.org/10.1111/j.1432-2277.2007.00602.x.
Desrois, M., Caus, T., Belles, P.M., Dalmasso, C., Lan, C., Cozzone, P.J. and Bernard, M. (2005) ‘Nitric oxide pathway after long-term cold storage and reperfusion in a heterotopic rat heart transplantation model’, Transplantation proceedings, 37(10), pp. 4553–4555. Available at: https://doi.org/10.1016/j.transproceed.2005.10.105.
Iltis, I., Kober, F., Desrois, M., Dalmasso, C., Lan, C., Portha, B., Cozzone, P.J. and Bernard, M. (2005) ‘Defective myocardial blood flow and altered function of the left ventricle in type 2 diabetic rats: a noninvasive in vivo study using perfusion and cine magnetic resonance imaging’, Investigative Radiology, 40(1), pp. 19–26.
Desrois, M., Sidell, R.J., Gauguier, D., Davey, C.L., Radda, G.K. and Clarke, K. (2004) ‘Gender differences in hypertrophy, insulin resistance and ischemic injury in the aging type 2 diabetic rat heart’, Journal of molecular and cellular cardiology, 37(2), pp. 547–555. Available at: https://doi.org/10.1016/j.yjmcc.2004.05.014.
Desrois, M., Sidell, R.J., Gauguier, D., King, L.M., Radda, G.K. and Clarke, K. (2004) ‘Initial steps of insulin signaling and glucose transport are defective in the type 2 diabetic rat heart’, Cardiovascular research, 61(2), pp. 288–296.
Kober, F., Iltis, I., Izquierdo, M., Desrois, M., Ibarrola, D., Cozzone, P.J. and Bernard, M. (2004) ‘High-resolution myocardial perfusion mapping in small animals in vivo by spin-labeling gradient-echo imaging’, Magnetic Resonance in Medicine, 51(1), pp. 62–67. Available at: https://doi.org/10.1002/mrm.10676.
Bernard, M., Robert, K., Caus, T., Desrois, M., Paganelli, F., Cozzone, P.J. and Maixent, J.M. (2004) ‘Protective effect of a low K+ cardioplegic solution on myocardial Na, K-ATPase activity.’, Cellular and molecular biology (Noisy-le-Grand, France), 50(7), p. 841. Available at: http://www.ncbi.nlm.nih.gov/pubmed/15672468 (Accessed: 21 November 2013).
Caus, T., Desrois, M., Izquierdo, M., Lan, C., LeFur, Y., Confort-Gouny, S., Métras, D., Clarke, K., Cozzone, P.J. and Bernard, M. (2003) ‘NOS substrate during cardioplegic arrest and cold storage decreases stunning after heart transplantation in a rat model’, The Journal of heart and lung transplantation: the official publication of the International Society for Heart Transplantation, 22(2), pp. 184–191.
Desrois, M., Sciaky, M., Lan, C., Cozzone, P.J. and Bernard, M. (2003) ‘Preservation of amino acids during long term ischemia and subsequent reflow with supplementation of L-arginine, the nitric oxide precursor, in the rat heart’, Amino acids, 24(1–2), pp. 141–148. Available at: http://link.springer.com/article/10.1007/s00726-002-0321-9 (Accessed: 21 November 2013).
Desrois, M., Caus, T., Lan, C., Sciaky, M., Cozzone, P.J. and Bernard, M. (2002) ‘Comparative effects of Celsior and a new cardioplegic solution on function, energy metabolism, and intracellular pH during long-term heart preservation’, Transplantation proceedings, 34(4), pp. 1259–1261.
Sidell, R.J., Cole, M.A., Draper, N.J., Desrois, M., Buckingham, R.E. and Clarke, K. (2002) ‘Thiazolidinedione treatment normalizes insulin resistance and ischemic injury in the zucker Fatty rat heart’, Diabetes, 51(4), pp. 1110–1117.
Desrois, M., Sciaky, M., Lan, C., Cozzone, P.J. and Bernard, M. (2000) ‘L-arginine during long-term ischemia: effects on cardiac function, energetic metabolism and endothelial damage’, The Journal of Heart and Lung Transplantation, 19(4), pp. 367–376. Available at: https://doi.org/10.1016/S1053-2498(00)00063-2.
Desrois, M., Sciaky, M., Lan, C., Cozzone, P.J. and Bernard, M. (1999) ‘Metabolic and functional effects of low-potassium cardioplegic solutions for long-term heart preservation’, Magnetic Resonance Materials in Physics, Biology and Medicine, 8(2), pp. 77–82. Available at: http://link.springer.com/article/10.1007/BF02590522 (Accessed: 21 November 2013).