Publications
180164
1
harvard-cite-them-right-no-et-al
50
date
desc
year
718
https://crmbm.univ-amu.fr/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A1750%2C%22request_next%22%3A50%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22G9HL6P42%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Agripnidis%20et%20al.%22%2C%22parsedDate%22%3A%222025-12%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BAgripnidis%2C%20T.%2C%20Ayobi%2C%20A.%2C%20Quenet%2C%20S.%2C%20Chaibi%2C%20Y.%2C%20Avare%2C%20C.%2C%20Jacquier%2C%20A.%2C%20Girard%2C%20N.%2C%20Hak%2C%20J.-F.%2C%20Reyre%2C%20A.%2C%20Brun%2C%20G.%20and%20El%20Ahmadi%2C%20A.-A.%20%282025%29%20%26%23x201C%3BPerformance%20of%20an%20artificial%20intelligence%20tool%20for%20multi-step%20acute%20stroke%20imaging%3A%20A%20multicenter%20diagnostic%20study%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BEuropean%20Journal%20of%20Radiology%20Open%26lt%3B%5C%2Fi%26gt%3B%2C%2015%2C%20p.%20100678.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.ejro.2025.100678%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.ejro.2025.100678%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Performance%20of%20an%20artificial%20intelligence%20tool%20for%20multi-step%20acute%20stroke%20imaging%3A%20A%20multicenter%20diagnostic%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thibault%22%2C%22lastName%22%3A%22Agripnidis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Angela%22%2C%22lastName%22%3A%22Ayobi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sarah%22%2C%22lastName%22%3A%22Quenet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yasmina%22%2C%22lastName%22%3A%22Chaibi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christophe%22%2C%22lastName%22%3A%22Avare%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexis%22%2C%22lastName%22%3A%22Jacquier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadine%22%2C%22lastName%22%3A%22Girard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Fran%5Cu00e7ois%22%2C%22lastName%22%3A%22Hak%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anthony%22%2C%22lastName%22%3A%22Reyre%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gilles%22%2C%22lastName%22%3A%22Brun%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ahmed-Ali%22%2C%22lastName%22%3A%22El%20Ahmadi%22%7D%5D%2C%22abstractNote%22%3A%22OBJECTIVE%3A%20Several%20artificial%20intelligence%20%28AI%29%20tools%20have%20been%20developed%20to%20assist%20in%20the%20stroke%20imaging%20workflow%2C%20which%20remains%20a%20major%20disease%20of%20the%2021st%20century.%20This%20study%20evaluated%20the%20combined%20performance%20of%20an%20FDA-cleared%20and%20CE-marked%20AI-based%20device%20with%20three%20modules%20designed%20to%20detect%20intracerebral%20hemorrhage%20%28ICH%29%2C%20identify%20large%20vessel%20occlusion%20%28LVO%29%2C%20and%20calculate%20Alberta%20Stroke%20Program%20Early%20CT%20Scores%20%28ASPECTS%29.%5CnMATERIALS%20%26amp%3B%20METHODS%3A%20Non-contrast%20CT%20%28NCCT%29%20and%5C%2For%20computed%20tomography%20angiography%20%28CTA%29%20for%20suspicion%20of%20stroke%20acquired%20at%20La%20Timone%20and%20Nord%20University%20hospitals%20%28Marseille%2C%20France%29%20between%20March%202019%20and%20March%202020%20were%20retrospectively%20collected.%20The%20AI%20tool%2C%20CINA-HEAD%20%28Avicenna.AI%29%2C%20processed%20the%20data%20to%20flag%20ICH%2C%20LVO%2C%20and%20calculate%20ASPECTS.%20The%20results%20were%20compared%20to%20ground%20truth%20evaluations%20by%20four%20expert%20neuroradiologists%20to%20compute%20diagnostic%20performances.%5CnRESULTS%3A%20A%20total%20of%20373%20NCCT%20and%20331%20CTA%20from%20405%20patients%20%28mean%20age%2064.9%5Cu202f%5Cu00b1%5Cu202f18.9%5Cu202fSD%2C%2052.6%5Cu202f%25%20female%29%20were%20included.%20The%20AI%20tool%20achieved%20an%20accuracy%20of%2094.6%5Cu202f%25%20%5B95%5Cu202f%25%20CI%3A%2091.8%5Cu202f%25-96.7%5Cu202f%25%5D%20for%20ICH%20detection%20on%20NCCT%20and%20of%2086.4%5Cu202f%25%20%5B95%5Cu202f%25%20CI%3A%2082.2%5Cu202f%25-89.9%5Cu202f%25%5D%20for%20LVO%20identification%20on%20CTA.%20The%20region-based%20ASPECTS%20analysis%20yielded%20an%20accuracy%20of%2088.6%5Cu202f%25%20%5B95%5Cu202f%25%20CI%3A%2087.8%5Cu202f%25-89.3%5Cu202f%25%5D%20and%20the%20dichotomized%20ASPECTS%20classification%20%28ASPECTS%20%5Cu2265%206%29%20achieved%2080.4%5Cu202f%25%20accuracy.%5CnCONCLUSION%3A%20This%20study%20demonstrates%20the%20reliable%2C%20stepwise%20performance%20of%20an%20AI-based%20stroke%20imaging%20tool%20across%20the%20diagnostic%20cascade%20of%20ICH%20and%20LVO%20detection%20and%20ASPECTS%20scoring.%20Such%20robust%20multi-stage%20evaluation%20supports%20its%20potential%20for%20streamlining%20acute%20stroke%20triage%20and%20decision-making.%22%2C%22date%22%3A%222025-12%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.ejro.2025.100678%22%2C%22ISSN%22%3A%222352-0477%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22KFZ6H27M%22%2C%22W98NEAUQ%22%5D%2C%22dateModified%22%3A%222025-11-27T10%3A56%3A26Z%22%7D%7D%2C%7B%22key%22%3A%22QNS6WJWJ%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Tikhonenko%20et%20al.%22%2C%22parsedDate%22%3A%222025-11-13%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BTikhonenko%2C%20D.%2C%20Rustomji%2C%20K.%2C%20Vilmen%2C%20C.%2C%20Durand%2C%20A.%2C%20Nouari%2C%20G.%2C%20Enoch%2C%20S.%2C%20Bendahan%2C%20D.%2C%20Abdeddaim%2C%20R.%20and%20Dubois%2C%20M.%20%282025%29%20%26%23x201C%3BOptimal%20excitation%20of%20single%20mode%20resonators%3A%20demonstration%20with%20a%203%26%23xA0%3BT%20MRI%20metasolenoid%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BJournal%20of%20Magnetic%20Resonance%20%28San%20Diego%2C%20Calif.%3A%201997%29%26lt%3B%5C%2Fi%26gt%3B%2C%20382%2C%20p.%20107992.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jmr.2025.107992%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jmr.2025.107992%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Optimal%20excitation%20of%20single%20mode%20resonators%3A%20demonstration%20with%20a%203%5Cu00a0T%20MRI%20metasolenoid%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dmitrii%22%2C%22lastName%22%3A%22Tikhonenko%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kaizad%22%2C%22lastName%22%3A%22Rustomji%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christophe%22%2C%22lastName%22%3A%22Vilmen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Arnaud%22%2C%22lastName%22%3A%22Durand%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Georges%22%2C%22lastName%22%3A%22Nouari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%22%2C%22lastName%22%3A%22Enoch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Bendahan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Redha%22%2C%22lastName%22%3A%22Abdeddaim%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marc%22%2C%22lastName%22%3A%22Dubois%22%7D%5D%2C%22abstractNote%22%3A%22Wireless%20passive%20resonators%20have%20been%20developed%20to%20inductively%20couple%20to%20the%20birdcage%20body%20coil.%20Such%20systems%20have%20been%20explored%20in%20the%20form%20of%20ceramic%20resonators%20with%20high%20permittivity%20but%20also%20with%20metamaterial%20or%20metasurface%20devices%20that%20can%20exhibit%20resonant%20behaviour%20at%20a%20given%20Larmor%20frequency.%20The%20resonant%20focusing%20of%20the%20radiofrequency%20field%20is%20used%20to%20lower%20the%20input%20power%20during%20transmission%20and%20improve%20the%20sensitivity%20of%20the%20body%20coil%20during%20reception.%20The%20gain%20is%20only%20obtained%20in%20a%20limited%20volume%20located%20within%20or%20close%20to%20the%20resonant%20structure.%20Typically%2C%20such%20passive%20devices%20do%20not%20support%20parallel%20imaging%20and%20demonstrated%20limited%20SNR%20enhancement%20compared%20to%20dense%20multichannel%20receive%20arrays.%20Nonetheless%2C%20these%20resonators%20have%20seen%20recent%20development%20with%20applications%20to%20wrist%20or%20breast%20MRI%20mostly%20in%201.5%5Cu00a0T%20MRI%20scanners.%20Here%20we%20propose%20to%20design%2C%20build%2C%20and%20study%20a%20metasolenoid%20resonator%20operating%20at%203%5Cu00a0T.%20The%20metasolenoid%20was%20characterized%20on%20phantom%20to%20validate%20the%20B1%20efficiency%20increase%20with%20respect%20to%20the%20birdcage%20polarization%20excitation.%20We%20reported%20a%20high%20B1%20efficiency%20gain%20for%20circularly%20%283.2-fold%29%20and%20linearly%20%285.8-fold%29%20polarized%20excitation.%20Consequently%2C%20and%20according%20to%20analytical%20calculations%2C%20we%20demonstrated%20that%20when%20excited%20with%20linearly%20polarized%20excitation%2C%20the%20metasolenoid%20had%20a%20B1%20efficiency%2026%5Cu00a0%25%20higher%20when%20excited%20by%20the%20default%20circularly%20polarized%20excitation.%20Numerical%20simulations%20on%20voxel%20model%20showed%20that%20in%20presence%20of%20the%20resonator%20the%20B1%20efficiency%20gain%20normalized%20by%20the%20maximum%20local%20SAR%20was%20significantly%20improved%20when%20introducing%20the%20metasolenoid%20but%20the%20influence%20of%20the%20excitation%20polarization%20was%20reduced%20to%20a%20few%20percent.%22%2C%22date%22%3A%222025-11-13%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.jmr.2025.107992%22%2C%22ISSN%22%3A%221096-0856%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%227FK4UDH9%22%2C%22NW6SZQBR%22%5D%2C%22dateModified%22%3A%222025-11-21T08%3A17%3A20Z%22%7D%7D%2C%7B%22key%22%3A%22Y8INPAUI%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Dalmas%20et%20al.%22%2C%22parsedDate%22%3A%222025-11-10%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BDalmas%2C%20F.%2C%20Foing%2C%20C.%2C%20Darrason%2C%20G.%2C%20Varoquaux%2C%20A.%2C%20Mazodier%2C%20K.%2C%20Muller%2C%20R.%2C%20Foletti%2C%20J.-M.%2C%20Guyot%2C%20L.%2C%20Cauchois%2C%20R.%2C%20Jean%2C%20R.%2C%20Kaplanski%2C%20G.%2C%20Cuny%2C%20T.%20and%20Jarrot%2C%20P.-A.%20%282025%29%20%26%23x201C%3BLong-term%20tocilizumab%20therapy%20in%20patients%20with%20corticosteroid-resistant%20active%20moderate-to-severe%20thyroid%20eye%20disease%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BEuropean%20Journal%20of%20Endocrinology%26lt%3B%5C%2Fi%26gt%3B%2C%20p.%20lvaf227.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fejendo%5C%2Flvaf227%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fejendo%5C%2Flvaf227%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Long-term%20tocilizumab%20therapy%20in%20patients%20with%20corticosteroid-resistant%20active%20moderate-to-severe%20thyroid%20eye%20disease%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florian%22%2C%22lastName%22%3A%22Dalmas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cl%5Cu00e9mence%22%2C%22lastName%22%3A%22Foing%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Genevi%5Cu00e8ve%22%2C%22lastName%22%3A%22Darrason%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Arthur%22%2C%22lastName%22%3A%22Varoquaux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%22%2C%22lastName%22%3A%22Mazodier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Romain%22%2C%22lastName%22%3A%22Muller%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Marc%22%2C%22lastName%22%3A%22Foletti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laurent%22%2C%22lastName%22%3A%22Guyot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rapha%5Cu00ebl%22%2C%22lastName%22%3A%22Cauchois%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rodolphe%22%2C%22lastName%22%3A%22Jean%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gilles%22%2C%22lastName%22%3A%22Kaplanski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Cuny%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pierre-Andr%5Cu00e9%22%2C%22lastName%22%3A%22Jarrot%22%7D%5D%2C%22abstractNote%22%3A%22OBJECTIVE%3A%20To%20evaluate%20the%20efficacy%20of%20long-term%20tocilizumab%20%28TCZ%29%20therapy%20in%20patients%20with%20corticosteroid-resistant%20moderate-to-severe%20thyroid%20eye%20disease%20%28TED%29.%5CnDESIGN%3A%20We%20conducted%20a%20single-center%20retrospective%20study%20involving%2026%20patients%20treated%20with%2012%20months%20of%20TCZ.%20The%20primary%20endpoint%20was%20the%20proportion%20of%20patients%20achieving%20a%20clinical%20activity%20score%20%28CAS%29%20%26lt%3B%203%20six%20months%20%28M6%29%20after%20TCZ%20initiation.%20Secondary%20outcomes%20included%20measuring%20changes%20in%20proptosis%2C%20diplopia%2C%20intraocular%20pressure%20%28IOP%29%2C%20and%20the%20detection%20of%20thyroid%20stimulating%20immunoglobulin%20%28TSI%29%20at%203-month%20intervals%20until%20M18%2C%20compared%20to%20baseline.%20The%20signal%20intensity%20ratio%20%28SIR%29%20was%20assessed%20on%20T2%20fat-saturated%20sequence%20magnetic%20resonance%20imaging%20%28MRI%29%20before%20treatment%20and%206%20months%20after%20commencing%20TCZ.%5CnRESULTS%3A%20At%20M6%2C%2058%25%20of%20patients%20achieved%20a%20CAS%20%26lt%3B%203%20%28p%26lt%3B0.001%29.%20The%20proportion%20of%20patients%20with%20a%20CAS%20%26lt%3B%203%20significantly%20increased%2C%20and%20the%20median%20CAS%20declined%20from%20M3%20to%20M18%20compared%20to%20baseline%2C%20as%20well%20as%20from%20M9%20and%20M12%20compared%20to%20M6.%20There%20was%20a%20significant%20reduction%20in%20the%20proportion%20of%20patients%20experiencing%20proptosis%2C%20diplopia%2C%20the%20median%20IOP%20and%20the%20detection%20of%20TSI%20throughout%20the%20follow-up%20period.%20At%20M12%2C%20two%20patients%20%287%2C7%25%29%20persisted%20with%20a%20CAS%20%5Cu2265%203%2C%20and%202%5C%2F24%20patients%20%288.3%25%29%20experienced%20a%20relapse%20by%20M18.%20Additionally%2C%20a%20significant%20decrease%20in%20both%20the%20SIR%20and%20the%20thickness%20of%20orbital%20muscles%20was%20observed%20between%20M0%20and%20M6.%5CnCONCLUSIONS%3A%20Six%20months-TCZ%20therapy%20results%20in%20control%20of%20more%20than%20half%20of%20patients%20with%20corticosteroid-resistant%20TED%20and%20may%20provide%20additional%20improvements%20beyond%206%20months.%20MRI%20might%20assist%20in%20the%20management%20of%20TED.%22%2C%22date%22%3A%222025-11-10%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1093%5C%2Fejendo%5C%2Flvaf227%22%2C%22ISSN%22%3A%221479-683X%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22KBIRKXGV%22%5D%2C%22dateModified%22%3A%222025-11-12T13%3A34%3A04Z%22%7D%7D%2C%7B%22key%22%3A%22UXT6JCKV%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Fournel%20et%20al.%22%2C%22parsedDate%22%3A%222025-11-07%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BFournel%2C%20J.%2C%20De%20Masi%2C%20M.%2C%20Lu%2C%20C.%2C%20Omnes%2C%20V.%2C%20Muselier%2C%20B.%2C%20Ghattas%2C%20B.%2C%20Bouchot%2C%20O.%2C%20Kafi%2C%20M.%2C%20Lalande%2C%20A.%2C%20Gaudry%2C%20M.%2C%20Jacquier%2C%20A.%20and%20Bartoli%2C%20A.%20%282025%29%20%26%23x201C%3BDeep%20learning-driven%20false-lumen%20volumes%20predict%20adverse%20remodeling%20better%20than%20diameter%20in%20patients%20with%20residual%20aortic%20dissection%20on%20CT%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BEuropean%20Radiology%26lt%3B%5C%2Fi%26gt%3B%20%5BPreprint%5D.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00330-025-12116-9%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00330-025-12116-9%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Deep%20learning-driven%20false-lumen%20volumes%20predict%20adverse%20remodeling%20better%20than%20diameter%20in%20patients%20with%20residual%20aortic%20dissection%20on%20CT%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joris%22%2C%22lastName%22%3A%22Fournel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mariangela%22%2C%22lastName%22%3A%22De%20Masi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Charlotte%22%2C%22lastName%22%3A%22Lu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Virgile%22%2C%22lastName%22%3A%22Omnes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Baptiste%22%2C%22lastName%22%3A%22Muselier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Badih%22%2C%22lastName%22%3A%22Ghattas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Olivier%22%2C%22lastName%22%3A%22Bouchot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Moundji%22%2C%22lastName%22%3A%22Kafi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alain%22%2C%22lastName%22%3A%22Lalande%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marine%22%2C%22lastName%22%3A%22Gaudry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexis%22%2C%22lastName%22%3A%22Jacquier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Axel%22%2C%22lastName%22%3A%22Bartoli%22%7D%5D%2C%22abstractNote%22%3A%22OBJECTIVES%3A%201.%20To%20develop%20a%20deep-learning%20segmentation%20model%20for%20automated%20measurement%20of%20maximal%20aortic%20diameter%20%28Dmax%29%20and%20volumes%20of%20aortic%20dissection%20components%3A%20true-lumen%20%28TL%29%2C%20circulating%20false-lumen%20%28CFL%29%2C%20and%20thrombus%20%28Th%29%20on%20CT%20angiography%20%28CTA%29.%202.%20To%20assess%20the%20predictive%20value%20of%20these%20measures%20for%20adverse%20aortic%20remodeling%20in%20residual%20aortic%20dissection%20%28RAD%29.%5CnMATERIALS%20AND%20METHODS%3A%20This%20retrospective%20study%20included%20322%20patients%20from%20two%20centers.%20The%20segmentation%20model%20was%20trained%20on%20120%20patients%20%28Center%201%29%20and%20tested%20on%20an%20internal%20dataset%20%2830%20patients%2C%20Center%201%29%20and%20an%20external%20dataset%20%2810%20patients%2C%20Center%202%29%20in%20terms%20of%20Dice%20Similarity%20Coefficient%20%28DSC%29.%20The%20model%20extracted%20Dmax%2C%20global%20false-lumen%20volume%20%28FLGlo%5Cu2009%3D%5Cu2009CFL%5Cu2009%2B%5Cu2009Th%29%2C%20and%20local%20false-lumen%20volume%20%28FLLoc%2C%20measured%203%5Cu2009cm%20around%20the%20largest%20diameter%29.%20Clinical%20validation%20was%20performed%20on%2083%20patients%20from%20Center1%20%28internal%20validation%2C%202-year%20follow-up%29%20and%2079%20patients%20from%20Center2%20%28external%20validation%2C%204.5-year%20follow-up%29.%5CnRESULTS%3A%20The%20segmentation%20model%20achieved%20high%20accuracy%20%28Center%201%2C%20DSC%3A%200.93%20TL%2C%200.93%20CFL%2C%200.87%20Th%3B%20Center%202%2C%20DSC%3A%200.92%20TL%2C%200.93%20CFL%2C%200.84%20Th%29%20with%20strong%20agreement%20between%20automated%20and%20manual%20measurements.%20Aortic%20remodeling%20occurred%20in%2039%5C%2F83%20patients%20%2846.9%25%29%20from%20Center1%20and%2033%5C%2F79%20patients%20%2841.7%25%29%20from%20Center2.%20Aortic%20remodeling%20occurred%20in%2039%5C%2F83%20patients%20%2847%25%29%20from%20Center1%20and%2033%5C%2F80%20%2842%25%29%20from%20Center2.%20FLLoc%20outperformed%20Dmax%20and%20FLGlo%20%28Center%201%3A%20AUC%5Cu2009%3D%5Cu20090.83%2C%200.73%2C%20and%200.76%3B%20Center%202%3A%20AUC%5Cu2009%3D%5Cu20090.77%2C%200.64%2C%20and%200.70%29.%20At%20optimal%20thresholds%2C%20FLLoc%20showed%20good%20predictive%20performance%20%28Center%201%3A%20Sensitivity%5Cu2009%3D%5Cu20090.87%2C%20Specificity%5Cu2009%3D%5Cu20090.68%29.%5CnCONCLUSION%3A%20Deep-learning%20segmentation%20provides%20accurate%20aortic%20measurements.%20Local%20false-lumen%20volumes%20predict%20adverse%20aortic%20remodeling%20in%20RAD%20better%20than%20diameter%20and%20global%20false-lumen%20volumes.%5CnKEY%20POINTS%3A%20Question%20In%20residual%20aortic%20dissection%20%28RAD%29%20after%20type-A%20dissection%2C%20early%20identification%20of%20high-risk%20patients%20on%20initial%20CT%20angiography%20is%20crucial%20for%20endovascular%20treatment%20decisions.%20Findings%20False-lumen%20local%20volumes%20%283%5Cu2009cm%20around%20aortic%20dissection%20maximal%20diameters%29%2C%20obtained%20with%20an%20automatic%20deep-learning%20method%2C%20predict%20adverse%20remodeling%20better%20than%20diameter%20or%20global%20false-lumen%20volumes.%20Clinical%20relevance%20A%20deep-learning%20segmentation%20method%20of%20aortic%20dissection%20components%20on%20CTA%2C%20enabling%20automatic%20measurements%20of%20diameters%20and%20volumes%20is%20feasible.%20It%20provides%20local%20false-lumen%20volumes%2C%20a%20better%20predictive%20marker%20of%20adverse%20aortic%20remodeling%20than%20the%20currently%20used%20diameters%20and%20global%20volumes.%22%2C%22date%22%3A%222025-11-07%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1007%5C%2Fs00330-025-12116-9%22%2C%22ISSN%22%3A%221432-1084%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22KFZ6H27M%22%2C%22CXAMISN8%22%5D%2C%22dateModified%22%3A%222025-11-27T10%3A53%3A30Z%22%7D%7D%2C%7B%22key%22%3A%22IRDNCDL2%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Gauer%20et%20al.%22%2C%22parsedDate%22%3A%222025-11-05%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BGauer%2C%20L.%2C%20Haast%2C%20R.A.M.%2C%20Azilinon%2C%20M.%2C%20El%20Mendili%2C%20M.M.%2C%20Makhalova%2C%20J.%2C%20Dary%2C%20H.%2C%20Dinkelacker%2C%20V.%2C%20Ridley%2C%20B.%2C%20Ranjeva%2C%20J.-P.%2C%20Zaaraoui%2C%20W.%2C%20Bartolomei%2C%20F.%20and%20Guye%2C%20M.%20%282025%29%20%26%23x201C%3BInvestigating%20sodium%20homeostasis%20of%20structural%20brain%20hubs%20in%20focal%20epilepsy%20using%207%20T%20MRI%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BBrain%3A%20A%20Journal%20of%20Neurology%26lt%3B%5C%2Fi%26gt%3B%2C%20p.%20awaf409.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fbrain%5C%2Fawaf409%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fbrain%5C%2Fawaf409%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Investigating%20sodium%20homeostasis%20of%20structural%20brain%20hubs%20in%20focal%20epilepsy%20using%207%20T%20MRI%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lucas%22%2C%22lastName%22%3A%22Gauer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Roy%20A.%20M.%22%2C%22lastName%22%3A%22Haast%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mikhael%22%2C%22lastName%22%3A%22Azilinon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mohamed%20Mounir%22%2C%22lastName%22%3A%22El%20Mendili%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Makhalova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hugo%22%2C%22lastName%22%3A%22Dary%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vera%22%2C%22lastName%22%3A%22Dinkelacker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ben%22%2C%22lastName%22%3A%22Ridley%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Philippe%22%2C%22lastName%22%3A%22Ranjeva%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wafaa%22%2C%22lastName%22%3A%22Zaaraoui%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabrice%22%2C%22lastName%22%3A%22Bartolomei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maxime%22%2C%22lastName%22%3A%22Guye%22%7D%5D%2C%22abstractNote%22%3A%22Besides%20their%20crucial%20role%20in%20cerebral%20connectivity%2C%20brain%20hubs%20are%20regions%20vulnerable%20to%20the%20energy%20deficit%20associated%20with%20various%20brain%20disorders.%20Changes%20in%20sodium%20homeostasis%20of%20cortical%20regions%20have%20been%20observed%20in%20focal%20epilepsy%20and%20may%20reflect%20energy%20failure.%20We%20investigated%20whether%20nodal%20structural%20connectivity%20is%20differently%20affected%20within%20the%20hub%20and%20non-hub%20regions%20by%20ionic%20perturbations%20associated%20with%20focal%20epilepsy.%20Our%20hypothesis%20was%20that%20the%20metabolic%20demands%20of%20hub%20regions%20may%20be%20associated%20with%20a%20distinct%20ionic%20profile%20detectable%20by%20sodium%20MRI%20and%20that%20this%20profile%20is%20altered%20in%20focal%20epilepsy.%20We%20included%2039%20patients%20with%20drug-resistant%20focal%20epilepsy%20and%2021%20age-%20and%20gender-matched%20healthy%20controls.%20Anatomical%2C%20diffusion-weighted%2C%20and%20sodium%20imaging%20was%20performed%20using%20a%207%20Tesla%20MRI%20scanner.%20Patients%20underwent%20pre-surgical%20work-up%2C%20including%20stereo-electroencephalographic%20recordings%20for%20defining%20the%20epileptogenic%20regions.%20Anatomical%20parcellation%20and%20multimodal%20coregistration%20allowed%20the%20use%20of%20parcels%20as%20nodes%20of%20whole-brain%20structural%20connectomes%2C%20linking%20structural%20connectivity%20measures%20to%20epileptogenicity%20and%20sodium%20parameters.%20Sodium%20parameters%20in%20patients%20were%20z-scored%20concerning%20homologous%20parcels%20in%20controls%20to%20allow%20comparison%20across%20regions%20of%20interest.%20Hub%20regions%20had%20higher%20total%20sodium%20concentration%20%28TSC%29%20than%20non-hub%20regions%20in%20both%20patients%20and%20controls%2C%20and%20this%20difference%20was%20not%20observed%20for%20sodium%20signal%20fraction%20%28f%2C%20a%20proxy%20of%20intracellular%20sodium%20homeostasis%29.%20Compared%20to%20controls%2C%20patients%20showed%20increased%20TSC%20in%20both%20epileptogenic%20and%20non-epileptogenic%20zones%2C%20and%20this%20increase%20in%20TSC%20was%20consistent%20in%20both%20hub%20and%20non-hub%20regions.%20On%20the%20contrary%2C%20f%20was%20increased%20only%20within%20the%20epileptogenic%20zones%20and%20was%20not%20affected%20by%20the%20hubness%20of%20a%20region.%20Our%20results%20also%20confirm%20the%20whole%20brain%20increase%20in%20TSC%20and%20the%20local%20increase%20of%20the%20f%20value%20within%20epileptogenic%20zones%20previously%20observed%20in%20focal%20epilepsy%20patients.%20Therefore%2C%20we%20propose%20that%20sodium%20imaging%20can%20probe%20distinct%20tissue%20properties%3A%20TSC%20appears%20sensitive%20to%20microstructural%20alterations%2C%20while%20f%20could%20reflect%20homeostatic%20disruptions%20specific%20to%20epileptogenic%20regions.%22%2C%22date%22%3A%222025-11-05%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1093%5C%2Fbrain%5C%2Fawaf409%22%2C%22ISSN%22%3A%221460-2156%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22KJQH9V8M%22%2C%22UP3H3ICX%22%2C%22HVJZKIZG%22%2C%22P66W67T8%22%2C%22F2AGIUQU%22%2C%22XTA6KS7L%22%2C%22FBQIKF54%22%2C%229RMECNPE%22%5D%2C%22dateModified%22%3A%222025-11-12T13%3A35%3A34Z%22%7D%7D%2C%7B%22key%22%3A%22C2999DIC%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Stellmann%20et%20al.%22%2C%22parsedDate%22%3A%222025-11-05%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BStellmann%2C%20J.-P.%2C%20Maarouf%2C%20A.%2C%20Nicolescu%2C%20M.%2C%20Boutiere%2C%20C.%2C%20Rico%2C%20A.%2C%20Zaaraoui%2C%20W.%2C%20Guye%2C%20M.%2C%20Pelletier%2C%20J.%2C%20Ranjeva%2C%20J.-P.%20and%20Audoin%2C%20B.%20%282025%29%20%26%23x201C%3BEarly%20structural%20hub%20disruption%20leads%20to%20premature%20functional%20adaption%20in%20multiple%20sclerosis%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BBrain%20Structure%20%26amp%3B%20Function%26lt%3B%5C%2Fi%26gt%3B%2C%20230%289%29%2C%20p.%20172.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00429-025-03023-2%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00429-025-03023-2%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Early%20structural%20hub%20disruption%20leads%20to%20premature%20functional%20adaption%20in%20multiple%20sclerosis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jan-Patrick%22%2C%22lastName%22%3A%22Stellmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Adil%22%2C%22lastName%22%3A%22Maarouf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mihaela%22%2C%22lastName%22%3A%22Nicolescu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cl%5Cu00e9mence%22%2C%22lastName%22%3A%22Boutiere%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Audrey%22%2C%22lastName%22%3A%22Rico%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wafaa%22%2C%22lastName%22%3A%22Zaaraoui%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maxime%22%2C%22lastName%22%3A%22Guye%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean%22%2C%22lastName%22%3A%22Pelletier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Phillipe%22%2C%22lastName%22%3A%22Ranjeva%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bertrand%22%2C%22lastName%22%3A%22Audoin%22%7D%5D%2C%22abstractNote%22%3A%22In%20Multiple%20Sclerosis%2C%20inflammation%20and%20neurodegeneration%20disrupt%20structural%20and%20functional%20brain%20networks.%20While%20the%20association%20between%20structural%20connectivity%20and%20disability%20is%20rather%20clear%2C%20functional%20connectivity%20changes%20are%20not%20yet%20characterised%20as%20a%20physiological%20response%20to%20the%20disease%2C%20as%20functionally%20meaningful%20adaptation%20or%20as%20a%20deceptive%20response.%20We%20explored%20the%20topology%20of%20brain%20networks%20of%2065%20Multiple%20Sclerosis%20patients%20over%20up%20to%20seven%20years%20in%20comparison%20to%2059%20controls.%20Connectomes%20based%20on%20probabilistic%20tractography%20from%20diffusion%20weighted%20imaging%20and%20resting-state%20MRI%2C%20were%20analysed%20with%20graph%20theory.%20The%20hub%20disruption%20index%20estimated%20connectivity%20perturbation%20in%20relation%20to%20the%20network%20hierarchy.%20In%20controls%2C%20we%20observed%20a%20transient%20increase%20in%20functional%20hub%20connectivity%20in%20the%205th%20and%206th%20age%20decade%20as%20a%20response%20to%20a%20subtle%20diffuse%20loss%20of%20structural%20connectivity%2C%20before%20structural%20and%20functional%20connectomes%20show%20a%20pronounced%20loss%20of%20hub%20connectivity.%20In%20Multiple%20Sclerosis%2C%20structural%20hub%20disruption%20was%20present%20from%20the%20disease%20onset%20while%20the%20transient%20upregulation%20of%20functional%20hub%20connectivity%20in%20the%20middle%20age%20was%20lacking.%20Patients%20seem%20to%20transition%20directly%20into%20an%20exhausted%20hub%20connectivity%20configuration.%20However%2C%20we%20observed%20the%20transient%20functional%20reorganisation%20of%20hubs%20in%20the%20first%20years%20after%20disease%20onset.%20Multiple%20Sclerosis%20patients%20present%20a%20probable%20physiological%20response%20to%20structural%20connectivity%20loss%20very%20early%20in%20the%20disease%2C%20potentially%20leading%20to%20an%20accelerated%20hub%20overload%20with%20accelerated%20neurodegeneration.%20The%20onset%20of%20chronic%20progression%20in%20the%205th%20age%20decade%20might%20be%20partially%20driven%20by%20the%20absence%20of%20the%20physiological%20increased%20hub%20connectivity%20observed%20in%20healthy%20individuals.%22%2C%22date%22%3A%222025-11-05%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1007%5C%2Fs00429-025-03023-2%22%2C%22ISSN%22%3A%221863-2661%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22KJQH9V8M%22%2C%22UP3H3ICX%22%2C%22B4EWFM7E%22%2C%229L2KHJ5X%22%2C%22XTA6KS7L%22%5D%2C%22dateModified%22%3A%222025-11-06T15%3A36%3A25Z%22%7D%7D%2C%7B%22key%22%3A%2247QU9FZH%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Grass%20et%20al.%22%2C%22parsedDate%22%3A%222025-11%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BGrass%2C%20L.%2C%20Grimaldi%2C%20S.%20and%20Damier%2C%20P.%20%282025%29%20%26%23x201C%3BProdromal%20Parkinson%26%23x2019%3Bs%20disease%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BRevue%20Neurologique%26lt%3B%5C%2Fi%26gt%3B%2C%20181%289%29%2C%20pp.%20863%26%23x2013%3B880.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.neurol.2025.06.012%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.neurol.2025.06.012%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Prodromal%20Parkinson%27s%20disease%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%22%2C%22lastName%22%3A%22Grass%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Grimaldi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P.%22%2C%22lastName%22%3A%22Damier%22%7D%5D%2C%22abstractNote%22%3A%22The%20neurodegenerative%20process%20responsible%20for%20Parkinson%26%23039%3Bs%20disease%20%28PD%29%20begins%20years%20before%20the%20level%20of%20dopamine%20denervation%20of%20the%20basal%20ganglia%20leads%20to%20the%20characteristic%20clinical%20phenotype%20of%20the%20disease.%20During%20the%20past%2020years%2C%20numerous%20symptoms%20that%20may%20occur%20during%20the%20prodromal%20stage%20of%20the%20disease%20have%20been%20identified%3A%20subtle%20motor%20symptoms%2C%20psychocognitive%20disorders%2C%20sleep%20disorders%2C%20sensorial%20dysfunction%2C%20and%20dysautonomia.%20Among%20them%2C%20rapid%20eye%20movement%20sleep%20behaviour%20disorder%20%28RBD%29%20is%20one%20of%20the%20most%20specific.%20The%20follow-up%20of%20cohorts%20of%20subjects%20affected%20by%20this%20disorder%20has%20provided%20valuable%20information%20about%20the%20prodromal%20stage%2C%20including%20evidence%20of%20various%20biological%20or%20imaging%20biomarkers%20associated%20with%20the%20pre-clinical%20stage%20of%20the%20disease.%20From%20all%20the%20knowledge%20acquired%20about%20this%20stage%20of%20the%20disease%2C%20criteria%20for%20diagnosing%20prodromal%20PD%20have%20been%20proposed%20and%20have%20progressively%20improved%20in%20sensitivity%20and%20specificity.%20The%20strong%20focus%20on%20the%20RBD-associated%20prodromal%20stage%20has%2C%20however%2C%20tended%20to%20conceal%20other%2C%20less%20florid%20forms%20of%20prodromal%20PD%2C%20such%20as%20those%20beginning%20with%20mild%20cognitive%20impairment%20or%20mild%20motor%20symptoms%2C%20which%20affected%20subjects%20are%20less%20likely%20to%20notice.%20Here%2C%20we%20review%20the%20various%20symptoms%20observed%20in%20the%20prodromal%20stage%20of%20PD%2C%20progress%20on%20identifying%20relevant%20imaging%20and%20biological%20biomarkers%2C%20and%20recent%20insights%20into%20the%20pathogenesis%20of%20a%20disease%20having%20such%20a%20wide%20spectrum%20of%20presentation%20and%20progression.%20Advances%20in%20knowledge%20about%20prodromal%20PD%20will%20lead%20to%20earlier%20diagnosis%20and%20better%20identification%20of%20prognostic%20factors%2C%20and%2C%20subsequently%2C%20to%20the%20capacity%20to%20initiate%20personalized%20treatment%20and%20potentially%20slow%20down%20the%20degenerative%20process.%22%2C%22date%22%3A%222025-11%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.neurol.2025.06.012%22%2C%22ISSN%22%3A%220035-3787%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22H8UPCNQI%22%5D%2C%22dateModified%22%3A%222025-11-17T08%3A21%3A34Z%22%7D%7D%2C%7B%22key%22%3A%22MXJEKN4G%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Wilson%20et%20al.%22%2C%22parsedDate%22%3A%222025-10-27%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BWilson%2C%20S.%2C%20Leray%2C%20E.%2C%20Calocer%2C%20F.%2C%20Rollot%2C%20F.%2C%20Fauvernier%2C%20M.%2C%20Remontet%2C%20L.%2C%20Launay%2C%20L.%2C%20Vukusic%2C%20S.%2C%20Le%20Page%2C%20E.%2C%20Debouverie%2C%20M.%2C%20Ciron%2C%20J.%2C%20Ruet%2C%20A.%2C%20Seze%2C%20J.D.%2C%20Zephir%2C%20H.%2C%20Moreau%2C%20T.%2C%20Laplaud%2C%20D.-A.%2C%20Lebrun-Frenay%2C%20C.%2C%20Clavelou%2C%20P.%2C%20Labauge%2C%20P.%2C%20Berger%2C%20E.%2C%20Pelletier%2C%20J.%2C%20Heinzlef%2C%20O.%2C%20Thouvenot%2C%20E.%2C%20Camdessanch%26%23xE9%3B%2C%20J.P.%2C%20Arnaud%2C%20C.%2C%20Derache%2C%20N.%2C%20Branger%2C%20P.%2C%20Guittet%2C%20L.%2C%20Defer%2C%20G.%20and%20Dejardin%2C%20O.%20%282025%29%20%26%23x201C%3BInfluence%20of%20geographical%20accessibility%20to%20specialist%20and%20primary%20care%20givers%20on%20excess%20mortality%20of%20multiple%20sclerosis%20patients%20in%20France%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BBMC%20neurology%26lt%3B%5C%2Fi%26gt%3B%2C%2025%281%29%2C%20p.%20441.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12883-025-04459-z%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12883-025-04459-z%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Influence%20of%20geographical%20accessibility%20to%20specialist%20and%20primary%20care%20givers%20on%20excess%20mortality%20of%20multiple%20sclerosis%20patients%20in%20France%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sarah%22%2C%22lastName%22%3A%22Wilson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Leray%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Floriane%22%2C%22lastName%22%3A%22Calocer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabien%22%2C%22lastName%22%3A%22Rollot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mathieu%22%2C%22lastName%22%3A%22Fauvernier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laurent%22%2C%22lastName%22%3A%22Remontet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ludivine%22%2C%22lastName%22%3A%22Launay%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sandra%22%2C%22lastName%22%3A%22Vukusic%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Le%20Page%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marc%22%2C%22lastName%22%3A%22Debouverie%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jonathan%22%2C%22lastName%22%3A%22Ciron%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aur%5Cu00e9lie%22%2C%22lastName%22%3A%22Ruet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00e9r%5Cu00f4me%20De%22%2C%22lastName%22%3A%22Seze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22H%5Cu00e9l%5Cu00e8ne%22%2C%22lastName%22%3A%22Zephir%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thibault%22%2C%22lastName%22%3A%22Moreau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David-Axel%22%2C%22lastName%22%3A%22Laplaud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christine%22%2C%22lastName%22%3A%22Lebrun-Frenay%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pierre%22%2C%22lastName%22%3A%22Clavelou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pierre%22%2C%22lastName%22%3A%22Labauge%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%22%2C%22lastName%22%3A%22Berger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean%22%2C%22lastName%22%3A%22Pelletier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Olivier%22%2C%22lastName%22%3A%22Heinzlef%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%22%2C%22lastName%22%3A%22Thouvenot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean%20Philippe%22%2C%22lastName%22%3A%22Camdessanch%5Cu00e9%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Charlotte%22%2C%22lastName%22%3A%22Arnaud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nathalie%22%2C%22lastName%22%3A%22Derache%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pierre%22%2C%22lastName%22%3A%22Branger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lydia%22%2C%22lastName%22%3A%22Guittet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gilles%22%2C%22lastName%22%3A%22Defer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Olivier%22%2C%22lastName%22%3A%22Dejardin%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Access%20to%20healthcare%20and%20socioeconomic%20deprivation%20are%20intricately%20linked.%20No%20studies%20have%20been%20led%20to%20measure%20the%20effect%20of%20healthcare%20accessibility%20on%20mortality%20in%20patients%20with%20MS%20so%20far.%20The%20objective%20was%20to%20examine%20the%20influence%20of%20travel%20time%20to%20the%20expert%20MS%20centre%20and%20of%20the%20accessibility%20to%20primary%20healthcare%20services%20on%20excess%20mortality%20in%20MS.%5CnMETHODS%3A%20A%20retrospective%20observational%20cohort%20study%20recruited%20patients%20from%2018%20French%20MS%20expert%20centres%2C%20with%20an%20onset%20of%20MS%20between%201960%20and%202015%20and%20a%20follow-up%20of%20up%20to%2030%5Cu00a0years.%20Primary%20health%20facility%20accessibility%20was%20measured%20by%20the%20Spatial%20aCcessibility%20multiscAlar%20index.%20Specialist%20care%20accessibility%20was%20measured%20by%20road%20travel%20time%20to%20the%20expert%20MS%20centre.%20Excess%20death%20rates%20%28EDR%29%20and%20excess%20hazard%20ratios%20were%20studied%20using%20additive%20excess%20hazard%20models%20with%20multidimensional%20penalised%20splines.%5CnRESULTS%3A%20The%20study%20included%2033%2C697%20patients.%20Patients%20with%20relapsing-onset%20MS%20%28R-MS%29%20with%20a%20travel%20time%20of%2040%5Cu00a0min%20had%20the%20lowest%20EDR%20%28Men%3A%201.2%20deaths%20per%20100%20person-years%20%2895%25CI%20%5B0.8%3B1.8%5D%29%2C%20women%3A%200.8%20deaths%20per%20100%20person-years%2095%25CI%5B0.6%3B1.2%5D%29%2C%20lower%20than%20patients%20who%20lived%20further%20from%20the%20centre.%20No%20effect%20of%20primary%20care%20access%20was%20found%20for%20patients%20with%20R-MS%2C%20and%20no%20effect%20of%20accessibility%20to%20primary%20or%20specialised%20care%20was%20found%20for%20patients%20with%20primary%20progressive%20MS.%5CnCONCLUSION%3A%20This%20study%20reveals%20the%20impact%20of%20travel%20time%20to%20neurologists%20on%20excess%20mortality%20in%20patients%20with%20R-MS%20in%20France.%20This%20distance%20bias%20association%20highlights%20the%20importance%20of%20preventing%20a%20potential%20selection%20of%20patients%20followed%20in%20MS%20expert%20centres.%22%2C%22date%22%3A%222025-10-27%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1186%5C%2Fs12883-025-04459-z%22%2C%22ISSN%22%3A%221471-2377%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22B4EWFM7E%22%2C%22B2M3AZVC%22%5D%2C%22dateModified%22%3A%222025-11-19T13%3A59%3A05Z%22%7D%7D%2C%7B%22key%22%3A%22HXBUH7GT%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Mira%20et%20al.%22%2C%22parsedDate%22%3A%222025-10-23%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BMira%2C%20V.%2C%20Stellman%2C%20J.P.%20and%20Grimaldi%2C%20S.%20%282025%29%20%26%23x201C%3BParoxysmal%20Dystonia%3A%20An%20Etiology%20Not%20to%20Be%20Missed%20in%20an%20Older%20Adult%20Patient%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BMovement%20Disorders%20Clinical%20Practice%26lt%3B%5C%2Fi%26gt%3B%20%5BPreprint%5D.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fmdc3.70407%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fmdc3.70407%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Paroxysmal%20Dystonia%3A%20An%20Etiology%20Not%20to%20Be%20Missed%20in%20an%20Older%20Adult%20Patient%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Valentin%22%2C%22lastName%22%3A%22Mira%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jan%20Patrick%22%2C%22lastName%22%3A%22Stellman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephan%22%2C%22lastName%22%3A%22Grimaldi%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222025-10-23%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1002%5C%2Fmdc3.70407%22%2C%22ISSN%22%3A%222330-1619%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%229L2KHJ5X%22%2C%22H8UPCNQI%22%5D%2C%22dateModified%22%3A%222025-10-30T10%3A31%3A39Z%22%7D%7D%2C%7B%22key%22%3A%22QZZX45WR%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Thakolwiboon%20et%20al.%22%2C%22parsedDate%22%3A%222025-09-23%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BThakolwiboon%2C%20S.%2C%20Redenbaugh%2C%20V.%2C%20Chen%2C%20B.%2C%20Hewitt%2C%20S.%2C%20Shah%2C%20S.%2C%20Lotan%2C%20I.%2C%20Levy%2C%20M.%2C%20Forcadela%2C%20M.%2C%20Huda%2C%20S.%2C%20Pique%2C%20J.%2C%20Marignier%2C%20R.%2C%20Boutiere%2C%20C.%2C%20Audoin%2C%20B.%2C%20Poullin%2C%20P.%2C%20Champsas%2C%20D.%2C%20Choi%2C%20D.%2C%20Danesh-Meyer%2C%20H.V.%2C%20Vasileiou%2C%20E.%2C%20Sotirchos%2C%20E.S.%2C%20Davis%2C%20J.B.%2C%20Henderson%2C%20A.D.%2C%20Wilf-Yarkoni%2C%20A.%2C%20Stiebel-Kalish%2C%20H.%2C%20Maillart%2C%20E.%2C%20Bonelli%2C%20L.%2C%20Arnold%2C%20A.C.%2C%20Boudot%20De%20La%20Motte%2C%20M.%2C%20Deschamps%2C%20R.%2C%20Jitprapaikulsan%2C%20J.%2C%20Moss%2C%20H.E.%2C%20Villarreal%20Navarro%2C%20S.E.%2C%20Mao-Draayer%2C%20Y.%2C%20Mishra%2C%20M.%2C%20Vorasoot%2C%20N.%2C%20Cacciaguerra%2C%20L.%2C%20Tisavipat%2C%20N.%2C%20Tajfirouz%2C%20D.A.%2C%20Tillema%2C%20J.-M.%2C%20Lopez-Chiriboga%2C%20S.A.%2C%20Palace%2C%20J.%2C%20Hacohen%2C%20Y.%2C%20Pittock%2C%20S.J.%2C%20Flanagan%2C%20E.P.%20and%20Chen%2C%20J.J.%20%282025%29%20%26%23x201C%3BOutcomes%20After%20Acute%20Plasma%20Exchange%20for%20Myelin%20Oligodendrocyte%20Glycoprotein%20Antibody-Associated%20Disease%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BNeurology%26lt%3B%5C%2Fi%26gt%3B%2C%20105%286%29%2C%20p.%20e213903.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1212%5C%2FWNL.0000000000213903%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1212%5C%2FWNL.0000000000213903%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Outcomes%20After%20Acute%20Plasma%20Exchange%20for%20Myelin%20Oligodendrocyte%20Glycoprotein%20Antibody-Associated%20Disease%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Smathorn%22%2C%22lastName%22%3A%22Thakolwiboon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vyanka%22%2C%22lastName%22%3A%22Redenbaugh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bo%22%2C%22lastName%22%3A%22Chen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sage%22%2C%22lastName%22%3A%22Hewitt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shailee%22%2C%22lastName%22%3A%22Shah%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Itay%22%2C%22lastName%22%3A%22Lotan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Levy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mirasol%22%2C%22lastName%22%3A%22Forcadela%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Saif%22%2C%22lastName%22%3A%22Huda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julie%22%2C%22lastName%22%3A%22Pique%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Romain%22%2C%22lastName%22%3A%22Marignier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Clemence%22%2C%22lastName%22%3A%22Boutiere%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bertrand%22%2C%22lastName%22%3A%22Audoin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pascale%22%2C%22lastName%22%3A%22Poullin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dimitrios%22%2C%22lastName%22%3A%22Champsas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Choi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Helen%20V.%22%2C%22lastName%22%3A%22Danesh-Meyer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elena%22%2C%22lastName%22%3A%22Vasileiou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elias%20S.%22%2C%22lastName%22%3A%22Sotirchos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22James%20B.%22%2C%22lastName%22%3A%22Davis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amanda%20D.%22%2C%22lastName%22%3A%22Henderson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Adi%22%2C%22lastName%22%3A%22Wilf-Yarkoni%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hadas%22%2C%22lastName%22%3A%22Stiebel-Kalish%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elisabeth%22%2C%22lastName%22%3A%22Maillart%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laura%22%2C%22lastName%22%3A%22Bonelli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anthony%20C.%22%2C%22lastName%22%3A%22Arnold%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marine%22%2C%22lastName%22%3A%22Boudot%20De%20La%20Motte%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Romain%22%2C%22lastName%22%3A%22Deschamps%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jiraporn%22%2C%22lastName%22%3A%22Jitprapaikulsan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Heather%20E.%22%2C%22lastName%22%3A%22Moss%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylvia%20E.%22%2C%22lastName%22%3A%22Villarreal%20Navarro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yang%22%2C%22lastName%22%3A%22Mao-Draayer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Murli%22%2C%22lastName%22%3A%22Mishra%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nisa%22%2C%22lastName%22%3A%22Vorasoot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laura%22%2C%22lastName%22%3A%22Cacciaguerra%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nanthaya%22%2C%22lastName%22%3A%22Tisavipat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Deena%20A.%22%2C%22lastName%22%3A%22Tajfirouz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jan-Mendelt%22%2C%22lastName%22%3A%22Tillema%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sebastian%20A.%22%2C%22lastName%22%3A%22Lopez-Chiriboga%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jacqueline%22%2C%22lastName%22%3A%22Palace%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yael%22%2C%22lastName%22%3A%22Hacohen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sean%20J.%22%2C%22lastName%22%3A%22Pittock%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eoin%20P.%22%2C%22lastName%22%3A%22Flanagan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22John%20J.%22%2C%22lastName%22%3A%22Chen%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%20AND%20OBJECTIVES%3A%20Data%20on%20the%20plasma%20exchange%20%28PLEX%29%20in%20myelin%20oligodendrocyte%20glycoprotein%20antibody-associated%20disease%20%28MOGAD%29%20are%20limited.%20Herein%2C%20we%20evaluate%20outcomes%20after%20PLEX%20in%20MOGAD.%5CnMETHODS%3A%20This%20international%20multicenter%20retrospective%20cohort%20study%20included%20patients%20from%2018%20tertiary%20care%20centers%20in%206%20countries.%20Inclusion%20criteria%20included%20fulfillment%20of%20the%202023%20International%20MOGAD%20panel%20criteria%2C%20receipt%20of%20at%20least%203%20sessions%20of%20PLEX%2C%20and%20follow-up%20of%20%5Cu22653%20months%20after%20PLEX.%20Patients%20with%20coexisting%20neuroinflammatory%20disorders%20were%20excluded.%20We%20assessed%20the%20frequency%20of%20complete%20recovery%20%28CR%29%2C%20clinically%20significant%20improvement%20%28CSI%29%2C%20visual%20acuity%20%28VA%29%2C%20and%20Expanded%20Disability%20Status%20Scale%20%28EDSS%29.%20Logistic%20regression%20analyses%20were%20performed%20to%20identify%20predictors%20of%20CR%20and%20CSI.%5CnRESULTS%3A%20Of%20234%20patients%2C%20135%20%2858%25%29%20were%20female.%20The%20median%20%28interquartile%20range%20%5BIQR%5D%29%20age%20at%20attack%20was%2034%20%28IQR%2022-49%29%20years%2C%20and%2042%20%2817%25%29%20were%20children.%20In%20165%20of%20243%20%2868%25%29%2C%20the%20attack%20treated%20with%20PLEX%20was%20the%20first%20attack.%20Attack%20phenotypes%20included%20161%20optic%20neuritis%20%28235%20eyes%29%2C%2077%20myelitis%2C%2024%20acute%20disseminated%20encephalomyelitis%2C%2015%20brainstem%5C%2Fcerebellar%2C%203%20cerebral-cortical%20encephalitis%20attack%2C%20and%201%20cerebral%20polyfocal%20deficit-36%20with%20%26gt%3B1%20core%20phenotypes.%20A%20total%20of%20239%20%2899%25%29%20attacks%20were%20also%20treated%20with%20corticosteroids%20and%2032%20%2813%25%29%20with%20IV%20immunoglobulins.%20VA%20in%20optic%20neuritis%20improved%20from%2020%5C%2F400%20%2820%5C%2F70-hand%20motion%29%20to%2020%5C%2F20%20%2820%5C%2F20-20%5C%2F30%29%2C%20p%20%26lt%3B%200.001%2C%20and%20EDSS%20decreased%20from%20a%20median%20of%204.0%20%283.0-6.5%29%20to%201.0%20%280.0-2.5%29%2C%20p%20%26lt%3B%200.001.%20Of%20229%20attacks%20without%20subsequent%20attacks%20within%203%20months%2C%20100%20%2844%25%29%20achieved%20CR%20and%20213%20%2893%25%29%20CSI.%20The%20probability%20of%20CR%20was%20decreased%20with%20advanced%20age%20%28adjusted%20odd%20ratio%20%5B95%25%20CI%5D%200.97%20%5B0.96-0.99%5D%20per%20year%29%2C%20higher%20EDSS%20worsening%20from%20baseline%20%280.66%20%5B0.54-0.81%5D%20per%200.5%20increment%29%20and%20delayed%20PLEX%20%280.98%20%5B0.96-0.99%5D%20per%20day%29.%20Advanced%20age%20%280.97%20%5B0.96-0.99%5D%20per%20year%29%20and%20delayed%20PLEX%20%280.95%20%5B0.94-0.96%5D%20per%20day%29%20decreased%20the%20probability%20of%20CSI.%5CnDISCUSSION%3A%20We%20observed%20favorable%20outcomes%20after%20PLEX%20in%20MOGAD%20attacks.%20However%2C%20advanced%20age%20and%20delayed%20initiation%20of%20PLEX%20were%20associated%20with%20a%20reduced%20probability%20of%20improvement.%20The%20absence%20of%20a%20control%20group%20limits%20our%20ability%20to%20differentiate%20PLEX%20effects%20from%20spontaneous%20recovery%2C%20prior%20corticosteroid%20response%2C%20or%20long-term%20immunotherapy.%20Future%20prospective%20studies%20are%20needed%20to%20assess%20the%20impact%20of%20PLEX%20on%20improvement.%5CnCLASSIFICATION%20OF%20EVIDENCE%3A%20This%20study%20provides%20Class%20IV%20evidence%20that%20PLEX%20is%20associated%20with%20favorable%20clinical%20outcomes%20in%20patients%20with%20MOGAD.%22%2C%22date%22%3A%222025-09-23%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1212%5C%2FWNL.0000000000213903%22%2C%22ISSN%22%3A%221526-632X%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%226KPLZTET%22%5D%2C%22dateModified%22%3A%222025-09-01T08%3A42%3A02Z%22%7D%7D%2C%7B%22key%22%3A%222EDLR7UJ%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Melka%20et%20al.%22%2C%22parsedDate%22%3A%222025-09-19%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BMelka%2C%20M.%2C%20Rotard%2C%20L.%2C%20Benstaali%2C%20C.%2C%20Brocard%2C%20J.%2C%20Giannesini%2C%20B.%2C%20Jouve%2C%20F.%2C%20Pelletier%2C%20L.%2C%20Faur%26%23xE9%3B%2C%20J.%2C%20Rendu%2C%20J.%2C%20Jacquemond%2C%20V.%20and%20Marty%2C%20I.%20%282025%29%20%26%23x201C%3BLimited%20pre-clinical%20relevance%20of%20the%20heterozygous%20RYR1-I4895T%5C%2F%2B%20mouse%20model%20due%20to%20its%20mild%20phenotype%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BJournal%20of%20Neuromuscular%20Diseases%26lt%3B%5C%2Fi%26gt%3B%2C%20p.%2022143602251339354.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1177%5C%2F22143602251339354%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1177%5C%2F22143602251339354%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Limited%20pre-clinical%20relevance%20of%20the%20heterozygous%20RYR1-I4895T%5C%2F%2B%20mouse%20model%20due%20to%20its%20mild%20phenotype%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Margaux%22%2C%22lastName%22%3A%22Melka%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ludivine%22%2C%22lastName%22%3A%22Rotard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Caroline%22%2C%22lastName%22%3A%22Benstaali%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julie%22%2C%22lastName%22%3A%22Brocard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benoit%22%2C%22lastName%22%3A%22Giannesini%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fanny%22%2C%22lastName%22%3A%22Jouve%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laurent%22%2C%22lastName%22%3A%22Pelletier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julien%22%2C%22lastName%22%3A%22Faur%5Cu00e9%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22John%22%2C%22lastName%22%3A%22Rendu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%22%2C%22lastName%22%3A%22Jacquemond%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Isabelle%22%2C%22lastName%22%3A%22Marty%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Although%20genetically-engineered%20mouse%20models%20are%20revolutionizing%20our%20understanding%20of%20numerous%20human%20diseases%2C%20some%20of%20them%20fail%20to%20reproduce%20or%20to%20mimic%20the%20human%20condition%20or%20even%20exhibit%20distinct%20disease%20features%20depending%20on%20the%20mouse%20genetic%20background%2C%20on%20the%20environment%20conditions%2C%20and%5C%2For%20on%20unknown%20parameters.%5CnOBJECTIVE%3A%20Experiments%20aimed%20at%20further%20characterizing%20the%20muscle%20defects%20associated%20with%20the%20I-T%20substitution%20at%20position%204898%20of%20the%20human%20type%201%20ryanodine%20receptor%20%28RyR1%29%20protein%20sequence%2C%20responsible%20for%20central%20core%20disease%20in%20affected%20patients%2C%20to%20use%20this%20model%20for%20therapeutic%20development.%20RyR1%20is%20a%20cationic%20channel%20in%20the%20sarcoplasmic%20reticulum%20membrane%20that%20is%20responsible%20for%20the%20Ca2%2B%20release%20flux%20that%20triggers%20muscle%20contraction.%20The%20above%20I-T%20change%20was%20previously%20described%20to%20alter%20RyR1%20channel%20permeation%20so%20as%20to%20produce%20muscle%20weakness.%5CnMETHODS%3A%20We%20used%20the%20corresponding%20I4895T%20mouse%20model%2C%20previously%20shown%20unviable%20in%20the%20homozygous%20form%2C%20and%20with%20heterozygous%20animals%20suffering%20from%20depressed%20RyR1-mediated%20Ca2%2B%20flux%20and%20muscle%20force%20production.%20We%20performed%20a%20full%20characterization%2C%20at%20the%20molecular%20level%20of%20the%20RYR1%20gene%20and%20transcript%2C%20and%20at%20the%20functional%20level%20at%20the%20isolated%20fiber%20or%20whole%20animal%20levels.%5CnRESULTS%3A%20We%20found%20no%20significant%20deficit%20in%20the%20heterozygous%20animals%2C%20from%20force%20and%20activity%20parameters%20at%20the%20whole%20organism%20level%2C%20to%20contraction%20of%20isolated%20muscles%20and%20Ca2%2B%20release%20in%20single%20isolated%20muscle%20fibers.%5CnCONCLUSIONS%3A%20Our%20results%20prompt%20the%20need%20for%20caution%20when%20using%20this%20model%2C%20and%20point%20to%20its%20potential%20limited%20relevance%20for%20preclinical%20studies.%22%2C%22date%22%3A%222025-09-19%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1177%5C%2F22143602251339354%22%2C%22ISSN%22%3A%222214-3602%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%226DHTGFMA%22%5D%2C%22dateModified%22%3A%222025-11-19T13%3A58%3A59Z%22%7D%7D%2C%7B%22key%22%3A%22P2YFJ85J%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Feys%20et%20al.%22%2C%22parsedDate%22%3A%222025-09-10%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BFeys%2C%20O.%2C%20Makhalova%2C%20J.%2C%20Manners%2C%20T.%2C%20Herrera-Garc%26%23xED%3Ba%2C%20J.-D.%2C%20Carron%2C%20R.%20and%20Bartolomei%2C%20F.%20%282025%29%20%26%23x201C%3BRadiofrequency%20thermocoagulation%20for%20the%20treatment%20of%20refractory%20focal%20status%20epilepticus%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BEpileptic%20Disorders%3A%20International%20Epilepsy%20Journal%20with%20Videotape%26lt%3B%5C%2Fi%26gt%3B%20%5BPreprint%5D.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fepd2.70091%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fepd2.70091%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Radiofrequency%20thermocoagulation%20for%20the%20treatment%20of%20refractory%20focal%20status%20epilepticus%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Odile%22%2C%22lastName%22%3A%22Feys%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Makhalova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Manners%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jos%5Cu00e9-David%22%2C%22lastName%22%3A%22Herrera-Garc%5Cu00eda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Romain%22%2C%22lastName%22%3A%22Carron%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabrice%22%2C%22lastName%22%3A%22Bartolomei%22%7D%5D%2C%22abstractNote%22%3A%22This%20case%20study%20reports%20the%20first%20documented%20use%20of%20stereoelectroencephalography%20%28SEEG%29-guided%20radiofrequency%20thermocoagulation%20%28RFTC%29%20to%20treat%20refractory%20status%20epilepticus%20%28RSE%29.%20A%2033-year-old%20woman%20with%20drug-resistant%20epilepsy%20and%20recurrent%20RSE%20underwent%20SEEG%20to%20define%20her%20epileptogenic%20zone.%20A%20new%20RSE%20started%20shortly%20before%20and%20continued%20during%20the%20SEEG%20exploration%2C%20being%20unresponsive%20to%20multiple%20antiseizure%20medications%2C%20vagal%20nerve%20stimulation%2C%20and%20corticosteroid%20therapy.%20SEEG-signal%20quantification%20based%20on%20ictal%20biomarkers%2C%20that%20is%2C%20epileptogenicity%20index%20and%20connectivity%20epileptogenicity%20index%2C%20identified%20the%20epileptogenic%20zone%20network%20%28EZN%29%20within%20the%20mesial%20prefrontal%2C%20premotor%2C%20and%20parietal%20cortex%2C%20with%20major%20implication%20of%20the%20anterior-middle%20and%20posterior%20cingulate%20cortex.%20RFTC%20was%20performed%20on%20SEEG-identified%20targets%20within%20the%20EZN%20and%20resulted%20in%20rapid%20cessation%20of%20electroclinical%20seizure%20activity%20and%20full%20recovery%20from%20motor%20deficits.%20Seizure%20frequency%20remained%20reduced%20by%20over%2090%25%20at%204%20months%20post-procedure.%20This%20case%20highlights%20the%20potential%20of%20RFTC%20as%20a%20possible%20therapeutic%20option%20for%20RSE%20by%20directly%20disrupting%20critical%20network%20nodes%20responsible%20for%20seizure%20generation%20and%20propagation.%20The%20findings%20also%20suggest%20a%20broader%20role%20of%20SEEG%20not%20only%20for%20diagnostic%20purposes%20but%20also%20for%20the%20therapeutic%20management%20of%20refractory%20seizures%2C%20including%20status%20epilepticus.%22%2C%22date%22%3A%222025-09-10%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1002%5C%2Fepd2.70091%22%2C%22ISSN%22%3A%221950-6945%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%229RMECNPE%22%5D%2C%22dateModified%22%3A%222025-09-11T07%3A30%3A55Z%22%7D%7D%2C%7B%22key%22%3A%22T9ZKI5F9%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Martin%20et%20al.%22%2C%22parsedDate%22%3A%222025-09-08%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BMartin%2C%20S.%2C%20Trabelsi%2C%20A.%2C%20Guye%2C%20M.%2C%20Dubois%2C%20M.%2C%20Abdeddaim%2C%20R.%2C%20Bendahan%2C%20D.%20and%20Andr%26%23xE9%3B%2C%20R.%20%282025%29%20%26%23x201C%3BOptimized%20reconstruction%20of%20undersampled%20Dixon%20sequences%20using%20new%20memory-efficient%20unrolled%20deep%20neural%20networks%3A%20HalfVarNet%20and%20HalfDIRCN%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BMagnetic%20Resonance%20in%20Medicine%26lt%3B%5C%2Fi%26gt%3B%20%5BPreprint%5D.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fmrm.70070%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fmrm.70070%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Optimized%20reconstruction%20of%20undersampled%20Dixon%20sequences%20using%20new%20memory-efficient%20unrolled%20deep%20neural%20networks%3A%20HalfVarNet%20and%20HalfDIRCN%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sandra%22%2C%22lastName%22%3A%22Martin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amira%22%2C%22lastName%22%3A%22Trabelsi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maxime%22%2C%22lastName%22%3A%22Guye%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marc%22%2C%22lastName%22%3A%22Dubois%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Redha%22%2C%22lastName%22%3A%22Abdeddaim%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Bendahan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R%5Cu00e9mi%22%2C%22lastName%22%3A%22Andr%5Cu00e9%22%7D%5D%2C%22abstractNote%22%3A%22PURPOSE%3A%20Fat%20fraction%20%28FF%29%20quantification%20in%20individual%20muscles%20using%20quantitative%20MRI%20is%20of%20major%20importance%20for%20monitoring%20disease%20progression%20and%20assessing%20disease%20severity%20in%20neuromuscular%20diseases.%20Undersampling%20of%20MRI%20acquisitions%20is%20commonly%20used%20to%20reduce%20scanning%20time.%20The%20present%20paper%20introduces%20novel%20unrolled%20neural%20networks%20for%20the%20reconstruction%20of%20undersampled%20MRI%20acquisitions.%20These%20networks%20are%20designed%20with%20the%20aim%20of%20maintaining%20accurate%20FF%20quantification%20while%20reducing%20reconstruction%20time%20and%20memory%20usage.%5CnMETHODS%3A%20The%20proposed%20approach%20relies%20on%20a%20combination%20of%20a%20simplified%20architecture%20%28Half%20U-Net%29%20with%20unrolled%20networks%20that%20achieved%20high%20performance%20in%20the%20well-known%20FastMRI%20challenge%20%28variational%20network%20%5BVarNet%5D%20and%20densely%20interconnected%20residual%20cascading%20network%20%5BDIRCN%5D%29.%20The%20algorithms%20were%20trained%20and%20evaluated%20using%203D%20MRI%20Dixon%20acquisitions%20of%20the%20thigh%20from%20controls%20and%20patients%20with%20neuromuscular%20diseases.%20The%20study%20was%20performed%20by%20applying%20a%20retrospective%20undersampling%20with%20acceleration%20factors%20of%204%20and%208.%20Reconstructed%20images%20were%20used%20to%20computed%20FF%20maps.%5CnRESULTS%3A%20Results%20disclose%20that%20the%20novel%20unrolled%20neural%20networks%20were%20able%20to%20maintain%20reconstruction%2C%20biomarker%20assessment%2C%20and%20segmentation%20quality%20while%20reducing%20memory%20usage%20by%2024%25%20to%2016%25%20and%20reducing%20reconstruction%20time%20from%2021%25%20to%2017%25.%20Using%20an%20acceleration%20factor%20of%208%2C%20the%20proposed%20algorithms%2C%20HalfVarNet%20and%20HalfDIRCN%2C%20achieved%20structural%20similarity%20index%20%28SSIM%29%20scores%20of%2093.76%5Cu2009%5Cu00b1%5Cu20090.38%20and%2094.95%5Cu2009%5Cu00b1%5Cu20090.32%2C%20mean%20squared%20error%20%28MSE%29%20values%20of%2012.76%5Cu2009%5Cu00b1%5Cu20091.08%5Cu2009%5Cu00d7%5Cu200910-2%20and%2010.25%5Cu2009%5Cu00b1%5Cu20090.87%20%5Cu00d7%5Cu200910-2%2C%20and%20a%20relative%20FF%20quadratic%20error%20of%200.23%5Cu2009%5Cu00b1%5Cu20090.02%25%20and%200.17%5Cu2009%5Cu00b1%5Cu20090.02%25%2C%20respectively.%5CnCONCLUSION%3A%20The%20proposed%20method%20enables%20time%20and%20memory-efficient%20reconstruction%20of%20undersampled%203D%20MRI%20data%2C%20supporting%20its%20potential%20for%20clinical%20application.%22%2C%22date%22%3A%222025-09-08%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1002%5C%2Fmrm.70070%22%2C%22ISSN%22%3A%221522-2594%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22NW6SZQBR%22%2C%22XTA6KS7L%22%5D%2C%22dateModified%22%3A%222025-11-19T13%3A59%3A34Z%22%7D%7D%2C%7B%22key%22%3A%224BSRQP76%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Porto%20et%20al.%22%2C%22parsedDate%22%3A%222025-09-05%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BPorto%2C%20A.%2C%20Court%2C%20A.%2C%20Barral%2C%20P.A.%2C%20Boucekine%2C%20M.%2C%20Imbert%2C%20L.%2C%20Gariboldi%2C%20V.%2C%20Jacquier%2C%20A.%2C%20Collart%2C%20F.%2C%20Theron%2C%20A.%20and%20Gaudry%2C%20M.%20%282025%29%20%26%23x201C%3BEvolution%20of%20Aortic%20Root%20Preservation%20After%20Type%20A%20Acute%20Aortic%20Dissection%20Repair%3A%20Impact%20of%20Root-Residual%20Aortic%20Dissection%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BJournal%20of%20Clinical%20Medicine%26lt%3B%5C%2Fi%26gt%3B%2C%2014%2817%29%2C%20p.%206274.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3390%5C%2Fjcm14176274%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3390%5C%2Fjcm14176274%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Evolution%20of%20Aortic%20Root%20Preservation%20After%20Type%20A%20Acute%20Aortic%20Dissection%20Repair%3A%20Impact%20of%20Root-Residual%20Aortic%20Dissection%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alizee%22%2C%22lastName%22%3A%22Porto%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Axel%22%2C%22lastName%22%3A%22Court%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pierre%20Antoine%22%2C%22lastName%22%3A%22Barral%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mohamed%22%2C%22lastName%22%3A%22Boucekine%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laura%22%2C%22lastName%22%3A%22Imbert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vlad%22%2C%22lastName%22%3A%22Gariboldi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexis%22%2C%22lastName%22%3A%22Jacquier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Frederic%22%2C%22lastName%22%3A%22Collart%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexis%22%2C%22lastName%22%3A%22Theron%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marine%22%2C%22lastName%22%3A%22Gaudry%22%7D%5D%2C%22abstractNote%22%3A%22Background%3A%20The%20management%20of%20the%20aortic%20root%20in%20type%20A%20aortic%20dissection%20%28TAAD%29%20is%20challenging.%20Conservative%20aortic%20root%20repair%20is%20considered%20a%20reasonable%20option%20in%20most%20cases.%20This%20study%20aimed%20to%20analyze%20medium-term%20mortality%20and%20aortic%20root%20reintervention%20after%20TAAD.%20Methods%3A%20All%20patients%20with%20TAAD%20underwent%20prospective%20follow-ups%20between%202017%20and%202021.%20The%20primary%20endpoint%20was%20the%20increase%20in%20aortic%20root%20diameter%20and%20the%20rate%20of%20proximal%20root%20reintervention.%20The%20secondary%20endpoints%20were%20the%20risk%20factor%20and%20location%20for%20root-RAD%2C%20and%20risk%20factors%20for%20severe%20and%20moderate%20AR%20and%20mortality%20during%20follow-up.%20Results%3A%20A%20total%20of%20210%20patients%20were%20included%2C%20of%20which%20166%20%2879.0%25%29%20did%20not%20have%20root-RAD%20and%2044%20%2821.0%25%29%20had%20root-RAD%20after%20supracoronary%20aortic%20replacement.%20After%20a%20mean%20follow-up%20of%2041.1%20months%20%280-60%29%2C%20four%20patients%20%281.8%25%29%20died.%20No%20cases%20of%20aortic%20root%20rupture%20were%20reported.%20Two%20patients%20in%20the%20root-RAD%20group%20underwent%20aortic%20root%20reoperation.%20The%20aortic%20root%20diameter%20increased%20by%200.5%20mm%5C%2Fyear%20and%200.09%20mm%5C%2Fyear%20in%20the%20root-RAD%20and%20no-root-RAD%20groups%2C%20respectively%20%28p%20%3D%200.18%29.%20Root-RAD%20was%20a%20risk%20factor%20for%20severe%20AR%20%28HR%2019.6%3B%2095%25CI%3A%201.6-2.7%3B%20p%20%3D%200.05%29%20and%20an%20independent%20risk%20factor%20for%20moderate%20AR%20%28HR%2023.0%3B%2095%25CI%3A%202.8-2.9%3B%20p%20%3D%200.009%29.%20Conclusions%3A%20Without%20increasing%20long-term%20mortality%2C%20root-RAD%20increases%20the%20risks%20of%20AR%20and%20subsequent%20aortic%20root%20reintervention.%20Long-term%20follow-up%20is%20essential%20for%20monitoring%20aortic%20valve%20function.%22%2C%22date%22%3A%222025-09-05%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.3390%5C%2Fjcm14176274%22%2C%22ISSN%22%3A%222077-0383%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22KFZ6H27M%22%5D%2C%22dateModified%22%3A%222025-11-28T09%3A19%3A35Z%22%7D%7D%2C%7B%22key%22%3A%226L3SY3Y7%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Gavoille%20et%20al.%22%2C%22parsedDate%22%3A%222025-09-04%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BGavoille%2C%20A.%2C%20Nourredine%2C%20M.%2C%20Rollot%2C%20F.%2C%20Casey%2C%20R.%2C%20Mathey%2C%20G.%2C%20Kerbrat%2C%20A.%2C%20Ciron%2C%20J.%2C%20De%20S%26%23xE8%3Bze%2C%20J.%2C%20Stankoff%2C%20B.%2C%20Maillart%2C%20E.%2C%20Ruet%2C%20A.%2C%20Labauge%2C%20P.%2C%20Kwiatkowski%2C%20A.%2C%20Zephir%2C%20H.%2C%20Papeix%2C%20C.%2C%20Defer%2C%20G.%2C%20Lebrun-Frenay%2C%20C.%2C%20Moreau%2C%20T.%2C%20Laplaud%2C%20D.-A.%2C%20Berger%2C%20E.%2C%20Clavelou%2C%20P.%2C%20Thouvenot%2C%20E.%2C%20Heinzlef%2C%20O.%2C%20Pelletier%2C%20J.%2C%20Al%20Khedr%2C%20A.%2C%20Casez%2C%20O.%2C%20Bourre%2C%20B.%2C%20Wahab%2C%20A.%2C%20Magy%2C%20L.%2C%20Moulin%2C%20S.%2C%20Camdessanch%26%23xE9%3B%2C%20J.-P.%2C%20Doghri%2C%20I.%2C%20Sarov%2C%20M.%2C%20Hankiewicz%2C%20K.%2C%20Pottier%2C%20C.%2C%20Dos%20Santos%2C%20A.%2C%20Manchon%2C%20E.%2C%20Tchikviladze%2C%20M.%2C%20Rabilloud%2C%20M.%2C%20Subtil%2C%20F.%20and%20Vukusic%2C%20S.%20%282025%29%20%26%23x201C%3BTarget%20trial%20emulation%20to%20replicate%20randomised%20clinical%20trials%20using%20registry%20data%20in%20multiple%20sclerosis%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BJournal%20of%20Neurology%2C%20Neurosurgery%2C%20and%20Psychiatry%26lt%3B%5C%2Fi%26gt%3B%2C%20p.%20jnnp-2025-336762.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fjnnp-2025-336762%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fjnnp-2025-336762%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Target%20trial%20emulation%20to%20replicate%20randomised%20clinical%20trials%20using%20registry%20data%20in%20multiple%20sclerosis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antoine%22%2C%22lastName%22%3A%22Gavoille%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mikail%22%2C%22lastName%22%3A%22Nourredine%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabien%22%2C%22lastName%22%3A%22Rollot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Romain%22%2C%22lastName%22%3A%22Casey%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guillaume%22%2C%22lastName%22%3A%22Mathey%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne%22%2C%22lastName%22%3A%22Kerbrat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jonathan%22%2C%22lastName%22%3A%22Ciron%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00e9r%5Cu00f4me%22%2C%22lastName%22%3A%22De%20S%5Cu00e8ze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruno%22%2C%22lastName%22%3A%22Stankoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elisabeth%22%2C%22lastName%22%3A%22Maillart%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aurelie%22%2C%22lastName%22%3A%22Ruet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pierre%22%2C%22lastName%22%3A%22Labauge%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Arnaud%22%2C%22lastName%22%3A%22Kwiatkowski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Helene%22%2C%22lastName%22%3A%22Zephir%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Caroline%22%2C%22lastName%22%3A%22Papeix%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gilles%22%2C%22lastName%22%3A%22Defer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christine%22%2C%22lastName%22%3A%22Lebrun-Frenay%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thibault%22%2C%22lastName%22%3A%22Moreau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David-Axel%22%2C%22lastName%22%3A%22Laplaud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%22%2C%22lastName%22%3A%22Berger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pierre%22%2C%22lastName%22%3A%22Clavelou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%22%2C%22lastName%22%3A%22Thouvenot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Olivier%22%2C%22lastName%22%3A%22Heinzlef%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean%22%2C%22lastName%22%3A%22Pelletier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Abdullatif%22%2C%22lastName%22%3A%22Al%20Khedr%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Olivier%22%2C%22lastName%22%3A%22Casez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bertrand%22%2C%22lastName%22%3A%22Bourre%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Abir%22%2C%22lastName%22%3A%22Wahab%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laurent%22%2C%22lastName%22%3A%22Magy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sol%5Cu00e8ne%22%2C%22lastName%22%3A%22Moulin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Philippe%22%2C%22lastName%22%3A%22Camdessanch%5Cu00e9%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ines%22%2C%22lastName%22%3A%22Doghri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mariana%22%2C%22lastName%22%3A%22Sarov%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karolina%22%2C%22lastName%22%3A%22Hankiewicz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Corinne%22%2C%22lastName%22%3A%22Pottier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Am%5Cu00e9lie%22%2C%22lastName%22%3A%22Dos%20Santos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%22%2C%22lastName%22%3A%22Manchon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maia%22%2C%22lastName%22%3A%22Tchikviladze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Muriel%22%2C%22lastName%22%3A%22Rabilloud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabien%22%2C%22lastName%22%3A%22Subtil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sandra%22%2C%22lastName%22%3A%22Vukusic%22%7D%5D%2C%22abstractNote%22%3A%22BackgroundTarget%20trial%20emulation%20%28TTE%29%20offers%20a%20formal%20framework%20for%20causal%20inference%20using%20observational%20data%2C%20but%20its%20validity%20must%20be%20evaluated%20in%20each%20research%20domain%20by%20replicating%20randomised%20clinical%20trials%20%28RCTs%29.%20We%20aimed%20to%20replicate%20eight%20RCTs%20evaluating%20the%20efficacy%20of%20disease-modifying%20therapies%20%28DMTs%29%20in%20multiple%20sclerosis%20%28MS%29%20using%20French%20registry%20data.%5CnMETHODS%3A%20This%20multicentre%2C%20retrospective%2C%20observational%20study%20was%20conducted%20using%20data%20extracted%20in%20December%202023%20from%20the%20Observatoire%20Fran%5Cu00e7ais%20de%20la%20Scl%5Cu00e9rose%20en%20Plaques%20%28OFSEP%29%20database.%20For%20each%20emulated%20trial%2C%20patients%20were%20included%20when%20they%20initiated%20one%20of%20the%20DMT%20evaluated%20in%20the%20corresponding%20RCT%20and%20met%20its%20inclusion%20criteria.%20Clinical%20outcomes%20were%20the%20annualised%20relapse%20rate%20and%203-month%20confirmed%20Expanded%20Disability%20Status%20Scale%20progression.%20Radiological%20outcomes%20were%20new%5C%2Fenlarged%20T2-lesions%20and%20new%20gadolinium-enhanced%20T1-lesions%20on%20a%20brain%20MRI.%20A%20targeted%20maximum%20likelihood%20estimator%20was%20used%20to%20estimate%20the%20treatment%20effect%20adjusted%20for%20confounding%20factors%20between%20groups%20and%20corrected%20for%20censoring%20and%20missing%20outcome%20assessment.%5CnRESULTS%3A%2014%5Cu2009111%20patients%20were%20included%20in%20eight%20emulated%20trials%3A%20ASSESS%20%28fingolimod%20vs%20glatiramer%20acetate%29%2C%20BEYOND%20%28interferon%20beta%20vs%20glatiramer%20acetate%29%2C%20CONFIRM%20%28dimethyl%20fumarate%20%28DMF%29%20vs%20glatiramer%20acetate%29%2C%20OPERA%20%28ocrelizumab%20vs%20interferon%20beta%29%2C%20REGARD%20%28interferon%20beta%20vs%20glatiramer%20acetate%29%2C%20RIFUND-MS%20%28rituximab%20vs%20DMF%29%2C%20TENERE%20%28teriflunomide%20vs%20interferon%20beta%29%20and%20TRANSFORMS%20%28fingolimod%20vs%20interferon%20beta%29.%20Treatment%20effects%20estimated%20in%20emulated%20trials%20were%20concordant%20with%20RCT%20findings%20in%20seven%20of%20eight%20trials%20for%20relapse%20rate%2C%20and%20in%20all%20six%20trials%20assessing%20disability%20progression.%20Radiological%20outcomes%20were%20more%20challenging%20to%20replicate%3B%20concordance%20was%20achieved%20in%20three%20of%20five%20trials%20for%20new%20T2-lesions%2C%20and%20one%20of%20four%20trials%20for%20new%20gadolinium-enhanced%20T1-lesions.%5CnCONCLUSION%3A%20The%20combined%20use%20of%20a%20TTE%20methodology%20and%20high-quality%20registry%20data%20is%20a%20valid%20tool%20to%20evaluate%20treatment%20effectiveness%20in%20MS.%22%2C%22date%22%3A%222025-09-04%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1136%5C%2Fjnnp-2025-336762%22%2C%22ISSN%22%3A%221468-330X%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22B2M3AZVC%22%5D%2C%22dateModified%22%3A%222025-11-19T13%3A59%3A32Z%22%7D%7D%2C%7B%22key%22%3A%229MT4N55U%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Russell-Hallinan%20et%20al.%22%2C%22parsedDate%22%3A%222025-09%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BRussell-Hallinan%2C%20A.%2C%20Karuna%2C%20N.%2C%20Lezoualc%26%23x2019%3Bh%2C%20F.%2C%20Matullo%2C%20G.%2C%20Baker%2C%20H.%2C%20Bernard%2C%20M.%2C%20Devaux%2C%20Y.%2C%20Badimon%2C%20L.%2C%20Vilahur%2C%20G.%2C%20Rieusset%2C%20J.%2C%20Derumeaux%2C%20G.A.%20and%20Watson%2C%20C.J.%20%282025%29%20%26%23x201C%3BEstablished%20and%20Emerging%20Roles%20of%20Epigenetic%20Regulation%20in%20Diabetic%20Cardiomyopathy%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BDiabetes%5C%2FMetabolism%20Research%20and%20Reviews%26lt%3B%5C%2Fi%26gt%3B%2C%2041%286%29%2C%20p.%20e70081.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fdmrr.70081%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fdmrr.70081%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Established%20and%20Emerging%20Roles%20of%20Epigenetic%20Regulation%20in%20Diabetic%20Cardiomyopathy%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Adam%22%2C%22lastName%22%3A%22Russell-Hallinan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Narainrit%22%2C%22lastName%22%3A%22Karuna%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Frank%22%2C%22lastName%22%3A%22Lezoualc%27h%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Giuseppe%22%2C%22lastName%22%3A%22Matullo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hana%22%2C%22lastName%22%3A%22Baker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Monique%22%2C%22lastName%22%3A%22Bernard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yvan%22%2C%22lastName%22%3A%22Devaux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lina%22%2C%22lastName%22%3A%22Badimon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gemma%22%2C%22lastName%22%3A%22Vilahur%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jennifer%22%2C%22lastName%22%3A%22Rieusset%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Genevi%5Cu00e8ve%20A.%22%2C%22lastName%22%3A%22Derumeaux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chris%20J.%22%2C%22lastName%22%3A%22Watson%22%7D%5D%2C%22abstractNote%22%3A%22An%20increasing%20number%20of%20individuals%20are%20at%20high%20risk%20of%20type%202%20diabetes%20%28T2DM%29%20and%20its%20cardiovascular%20%28CV%29%20complications%2C%20which%20challenges%20healthcare%20systems%20with%20an%20increased%20risk%20of%20developing%20CV%20diseases.%20Patients%20with%20T2DM%20exhibit%20a%20unique%20cardiac%20phenotype%20termed%20diabetic%20cardiomyopathy%20%28DCM%29.%20DCM%20usually%20involves%20complex%20and%20multifactorial%20pathogenic%20drivers%2C%20including%20myocardial%20inflammation%2C%20fibrosis%2C%20hypertrophy%2C%20and%20early%20diastolic%20dysfunction%2C%20which%20potentially%20evolve%20into%20systolic%20dysfunction%20and%20heart%20failure.%20There%20is%20a%20lack%20of%20effective%20treatments%20for%20DCM%20on%20the%20basis%20of%20the%20complexity%20of%20the%20disease%20per%20se%20and%20poor%20understanding%20of%20the%20mechanisms%20behind%20disease%20development%20and%20progression.%20Despite%20the%20considerable%20research%20attention%20on%20the%20onset%20of%20DCM%20development%20and%20progression%2C%20understanding%20of%20the%20full%20spectrum%20of%20pathogenic%20mechanisms%20has%20not%20yet%20been%20fully%20deciphered.%20Epigenetic%20alterations%2C%20including%20DNA%20methylation%2C%20histone%20modifications%2C%20bromodomain%20extra-terminal%20%28BET%29-containing%20reader%20proteins%2C%20and%20RNA-based%20mechanisms%20%28e.g.%2C%20miRs%2C%20lncRNAs%2C%20circRNA%29%2C%20are%20significantly%20associated%20with%20the%20initiation%20and%20evolution%20of%20DCM%2C%20particularly%20in%20the%20early%20stage.%20In%20this%20review%2C%20we%20provide%20insights%20into%20the%20evidence%20of%20epigenetic%20alterations%20related%20to%20DCM%20development%20and%20progression%20characteristics.%20Furthermore%2C%20the%20uniqueness%20of%20epigenetic%20changes%20in%20DCM%20in%20specific%20cell%20types%20within%20diabetic%20hearts%20is%20discussed.%20We%20also%20review%20epigenetic%20cooperation%20in%20the%20context%20of%20DCM%20development%20and%20epigenetic%20biomarkers%20related%20to%20DCM%20progression.%20With%20recent%20advancements%20in%20technology%2C%20epitranscriptomics-related%20to%20DCM%20has%20been%20uniquely%20discussed.%20Finally%2C%20this%20review%20may%20provide%20new%20avenues%20for%20potential%20implications%20for%20future%20research%20and%20the%20discovery%20of%20novel%20treatment%20targets%20for%20preventing%20the%20onset%20and%20progression%20of%20DCM.%22%2C%22date%22%3A%222025-09%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1002%5C%2Fdmrr.70081%22%2C%22ISSN%22%3A%221520-7560%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%225Z6CVJGB%22%5D%2C%22dateModified%22%3A%222025-11-28T09%3A27%3A27Z%22%7D%7D%2C%7B%22key%22%3A%22MU4PAIR2%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Andikoetxea%20et%20al.%22%2C%22parsedDate%22%3A%222025-09%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BAndikoetxea%2C%20B.G.%2C%20Mart%26%23xED%3Bn-Bastida%2C%20A.%2C%20Vidorreta%2C%20M.%2C%20Rodr%26%23xED%3Bguez-Oroz%2C%20M.C.%2C%20Soustelle%2C%20L.%2C%20Troalen%2C%20T.%20and%20Fern%26%23xE1%3Bndez-Seara%2C%20M.A.%20%282025%29%20%26%23x201C%3BNeuromelanin%20Contrast%20Optimization%20and%20Improved%20Visualization%20of%20the%20Substantia%20Nigra%20in%20a%203D%20Gradient-Echo%20Sequence%20With%20Magnetization%20Transfer%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BNMR%20in%20biomedicine%26lt%3B%5C%2Fi%26gt%3B%2C%2038%289%29%2C%20p.%20e70123.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fnbm.70123%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fnbm.70123%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Neuromelanin%20Contrast%20Optimization%20and%20Improved%20Visualization%20of%20the%20Substantia%20Nigra%20in%20a%203D%20Gradient-Echo%20Sequence%20With%20Magnetization%20Transfer%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bego%5Cu00f1a%20Garate%22%2C%22lastName%22%3A%22Andikoetxea%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antonio%22%2C%22lastName%22%3A%22Mart%5Cu00edn-Bastida%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marta%22%2C%22lastName%22%3A%22Vidorreta%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mar%5Cu00eda%20Cruz%22%2C%22lastName%22%3A%22Rodr%5Cu00edguez-Oroz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lucas%22%2C%22lastName%22%3A%22Soustelle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Troalen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maria%20A.%22%2C%22lastName%22%3A%22Fern%5Cu00e1ndez-Seara%22%7D%5D%2C%22abstractNote%22%3A%22Neuromelanin%20%28NM%29%20magnetic%20resonance%20imaging%20has%20been%20used%20to%20evaluate%20the%20loss%20of%20melanized%20neurons%20in%20the%20substantia%20nigra%2C%20the%20main%20characteristic%20of%20Parkinson%20disease%2C%20typically%20by%20measuring%20the%20contrast%20ratio%20%28CR%29%20between%20the%20NM-rich%20areas%20and%20the%20cerebral%20peduncles%20in%20the%20midbrain.%20Neuromelanin%20contrast%20can%20be%20generated%20by%20employing%20a%203D%20gradient-echo%20%28GRE%29%20sequence%20with%20magnetization%20transfer%20%28MT%29.%20In%20this%20work%2C%20we%20first%20evaluated%20the%20effect%20of%20the%20MT%20pulse%20frequency%20on%20the%20CR%20and%20contrast-to-noise%20ratio%20%28CNR%29%2C%20analyzing%20a%20large%20frequency%20range%20from%20500%20to%20100K%5Cu2009Hz.%20Secondly%2C%20the%20impact%20of%20the%203D%20GRE%20sequence%20flip%20angle%20%28FA%29%20was%20evaluated%20using%20angles%20from%205%5Cu00b0%20to%2040%5Cu00b0.%20Additionally%2C%20images%20were%20acquired%20both%20with%20and%20without%20MT%20for%20each%20FA%2C%20providing%20an%20opportunity%20to%20examine%20the%20effect%20of%20MT%20on%20tissue%20proton%20density%2C%20T1%2C%20and%20T2%2A%20values.%20Results%20showed%20that%20the%20highest%20CR%20and%20CNR%20were%20obtained%20for%20the%20lower%20MT%20frequencies%20%28500-2000%5Cu2009Hz%29%20and%20lower%20FAs%20%285%5Cu00b0-10%5Cu00b0%29.%20The%20lower%20FAs%20improved%20the%20visualization%20of%20the%20neuromelanin-rich%20area%20in%20the%20substantia%20nigra%20and%20facilitated%20delineating%20its%20volume.%20In%20addition%2C%20this%20work%20showed%20that%20the%20MT%20pulse%20decreased%20the%20T1%20and%20PD%20of%20the%20tissue.%20Furthermore%2C%20simulations%20supported%20the%20obtained%20in%5Cu00a0vivo%20results.%22%2C%22date%22%3A%222025-09%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1002%5C%2Fnbm.70123%22%2C%22ISSN%22%3A%221099-1492%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%226GBQDAVI%22%2C%22M2AY8I5W%22%5D%2C%22dateModified%22%3A%222025-08-20T08%3A46%3A02Z%22%7D%7D%2C%7B%22key%22%3A%22EBKNBNNG%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Gavoille%20et%20al.%22%2C%22parsedDate%22%3A%222025-08-26%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BGavoille%2C%20A.%2C%20Leray%2C%20E.%2C%20Marignier%2C%20R.%2C%20Rollot%2C%20F.%2C%20Casey%2C%20R.%2C%20Mathey%2C%20G.%2C%20Michel%2C%20L.%2C%20De%20Seze%2C%20J.%2C%20Ciron%2C%20J.%2C%20Ruet%2C%20A.%2C%20Maillart%2C%20E.%2C%20Labauge%2C%20P.%2C%20Zephir%2C%20H.%2C%20Laplaud%2C%20D.A.%2C%20Papeix%2C%20C.%2C%20Defer%2C%20G.%2C%20Moreau%2C%20T.%2C%20Berger%2C%20E.%2C%20Dubessy%2C%20A.-L.%2C%20Clavelou%2C%20P.%2C%20Thouvenot%2C%20E.%2C%20Heinzlef%2C%20O.%2C%20Pelletier%2C%20J.%2C%20Al%20Khedr%2C%20A.%2C%20Casez%2C%20O.%2C%20Bourre%2C%20B.%2C%20Wahab%2C%20A.%2C%20Magy%2C%20L.%2C%20Camdessanche%2C%20J.-P.%2C%20Doghri%2C%20I.%2C%20Moulin%2C%20S.%2C%20Labeyrie%2C%20C.%2C%20Hankiewicz%2C%20K.%2C%20Dos%20Santos%2C%20A.%2C%20Pottier%2C%20C.%2C%20Manchon%2C%20E.%2C%20Tchikviladze%2C%20M.%2C%20Lebrun-Frenay%2C%20C.%2C%20Vukusic%2C%20S.%20and%20OFSEP%20investigators%20%282025%29%20%26%23x201C%3BSex-Related%20Gap%20in%20the%20Use%20of%20Disease-Modifying%20Therapies%20in%20Multiple%20Sclerosis%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BNeurology%26lt%3B%5C%2Fi%26gt%3B%2C%20105%284%29%2C%20p.%20e213907.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1212%5C%2FWNL.0000000000213907%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1212%5C%2FWNL.0000000000213907%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Sex-Related%20Gap%20in%20the%20Use%20of%20Disease-Modifying%20Therapies%20in%20Multiple%20Sclerosis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antoine%22%2C%22lastName%22%3A%22Gavoille%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Leray%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Romain%22%2C%22lastName%22%3A%22Marignier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabien%22%2C%22lastName%22%3A%22Rollot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Romain%22%2C%22lastName%22%3A%22Casey%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guillaume%22%2C%22lastName%22%3A%22Mathey%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laure%22%2C%22lastName%22%3A%22Michel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jerome%22%2C%22lastName%22%3A%22De%20Seze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jonathan%22%2C%22lastName%22%3A%22Ciron%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aur%5Cu00e9lie%22%2C%22lastName%22%3A%22Ruet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elisabeth%22%2C%22lastName%22%3A%22Maillart%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pierre%22%2C%22lastName%22%3A%22Labauge%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Helene%22%2C%22lastName%22%3A%22Zephir%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%20Axel%22%2C%22lastName%22%3A%22Laplaud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Caroline%22%2C%22lastName%22%3A%22Papeix%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gilles%22%2C%22lastName%22%3A%22Defer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thibault%22%2C%22lastName%22%3A%22Moreau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%22%2C%22lastName%22%3A%22Berger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne-Laure%22%2C%22lastName%22%3A%22Dubessy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pierre%22%2C%22lastName%22%3A%22Clavelou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%22%2C%22lastName%22%3A%22Thouvenot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Olivier%22%2C%22lastName%22%3A%22Heinzlef%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean%22%2C%22lastName%22%3A%22Pelletier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Abdullatif%22%2C%22lastName%22%3A%22Al%20Khedr%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Olivier%22%2C%22lastName%22%3A%22Casez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bertrand%22%2C%22lastName%22%3A%22Bourre%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Abir%22%2C%22lastName%22%3A%22Wahab%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laurent%22%2C%22lastName%22%3A%22Magy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Philippe%22%2C%22lastName%22%3A%22Camdessanche%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ines%22%2C%22lastName%22%3A%22Doghri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sol%5Cu00e8ne%22%2C%22lastName%22%3A%22Moulin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Celine%22%2C%22lastName%22%3A%22Labeyrie%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karolina%22%2C%22lastName%22%3A%22Hankiewicz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Am%5Cu00e9lie%22%2C%22lastName%22%3A%22Dos%20Santos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Corinne%22%2C%22lastName%22%3A%22Pottier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%22%2C%22lastName%22%3A%22Manchon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maya%22%2C%22lastName%22%3A%22Tchikviladze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christine%22%2C%22lastName%22%3A%22Lebrun-Frenay%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sandra%22%2C%22lastName%22%3A%22Vukusic%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22OFSEP%20investigators%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%20AND%20OBJECTIVES%3A%20In%20women%20with%20multiple%20sclerosis%20%28MS%29%2C%20the%20therapeutic%20strategy%20may%20be%20influenced%20by%20the%20anticipation%20of%20future%20pregnancies%2C%20leading%20to%20underexposure%20to%20disease-modifying%20therapies%20%28DMTs%29%20and%20highly%20effective%20DMTs%20%28HEDMTs%29%20compared%20with%20men.%20We%20aimed%20to%20evaluate%20potential%20therapeutic%20inertia%20in%20women%20with%20MS%20and%20explore%20its%20causes.%5CnMETHODS%3A%20We%20performed%20a%20retrospective%20cohort%20study%20based%20on%20data%20extracted%20on%20June%202023%20from%20the%20Observatoire%20Fran%5Cu00e7ais%20de%20la%20Scl%5Cu00e9rose%20en%20Plaques%20for%20all%20patients%20with%20a%20relapsing-remitting%20MS%20onset%20between%2018%20and%2040%20years.%20The%20primary%20outcome%20was%20the%20annual%20probability%20of%20receiving%20a%20DMT%2C%20accounting%20for%20sex%2C%20disease%20severity%2C%20and%20pregnancy%5C%2Fpostpartum%20periods.%20Secondary%20outcomes%20were%20the%20annual%20probability%20of%20receiving%20a%20HEDMT%2C%20each%20DMT%20separately%2C%20and%20interaction%20of%20the%20effect%20of%20sex%20with%20calendar%20year%2C%20patient%20age%2C%20and%20disease%20duration.%20We%20used%20a%20longitudinal%20logistic%20model%20with%20generalized%20estimating%20equations%20and%20an%20inverse-probability-of-censoring%20weighting.%5CnRESULTS%3A%20We%20included%2022%2C657%20patients%20with%20MS%3B%2016%2C857%20%2874.4%25%29%20were%20female%2C%20mean%20%28SD%29%20age%20at%20onset%20was%2029.0%20%286.0%29%20years%2C%20and%20median%20%28interquartile%20range%29%20follow-up%20duration%20was%2011.6%20%286.6-17.3%29%20years.%20Women%20were%20significantly%20less%20likely%20to%20receive%20a%20DMT%20%28odds%20ratio%20%5BOR%5D%200.92%2C%2095%25%20CI%200.87-0.97%29%20or%20a%20HEDMT%20%28OR%200.80%2C%2095%25%20CI%200.74-0.86%29.%20This%20difference%20appeared%202%20years%20after%20disease%20onset%20for%20DMTs%20and%201%20year%20for%20HEDMTs%2C%20and%20did%20not%20differ%20significantly%20according%20to%20patient%26%23039%3Bs%20age.%20Teriflunomide%2C%20sphingosine-1-phosphate%20receptor%20modulators%2C%20and%20anti-CD20s%20were%20significantly%20underused%20in%20women%20throughout%20their%20entire%20period%20of%20availability%3B%20interferons%20%5Cu03b2%20%28IFN-%5Cu03b2%29%20and%20natalizumab%20were%20initially%20less%20used%20and%20then%20equally%20after%20some%20time%3B%20glatiramer%20acetate%20and%20fumarates%20were%20first%20used%20equally%2C%20then%20more%20frequently%20in%20women.%20The%20proportion%20of%20treated%20women%2C%20analyzed%20from%20the%20first%20childbirth%20of%205%2C268%20women%2C%20began%20to%20decline%2018%20months%20before%20childbirth%2C%20from%2042.6%25%20to%2027.9%25%20at%20the%20estimated%20time%20of%20conception.%5CnDISCUSSION%3A%20Women%20with%20MS%20were%20significantly%20less%20exposed%20to%20DMTs%20compared%20with%20men.%20Anticipation%20of%20pregnancy%20was%20probably%20an%20important%20factor%20underlying%20this%20difference%2C%20but%20also%20sex-specific%20therapeutic%20inertia.%20Neurologists%20and%20patients%20should%20be%20educated%20on%20the%20most%20recent%20recommendations%20on%20the%20use%20of%20DMTs%20in%20the%20context%20of%20pregnancy%20to%20avoid%20deleterious%20therapeutic%20inertia.%22%2C%22date%22%3A%222025-08-26%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1212%5C%2FWNL.0000000000213907%22%2C%22ISSN%22%3A%221526-632X%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22B4EWFM7E%22%2C%22B2M3AZVC%22%5D%2C%22dateModified%22%3A%222025-11-19T13%3A59%3A24Z%22%7D%7D%2C%7B%22key%22%3A%223VN786HP%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Bernard%22%2C%22parsedDate%22%3A%222025-08-26%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BBernard%2C%20M.%20%282025%29%20%26%23x201C%3BAssessment%20of%20Left%20Atrial%20Fibrosis%20With%20Cardiac%20MRI%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BJournal%20of%20magnetic%20resonance%20imaging%3A%20JMRI%26lt%3B%5C%2Fi%26gt%3B%20%5BPreprint%5D.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjmri.70103%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjmri.70103%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Assessment%20of%20Left%20Atrial%20Fibrosis%20With%20Cardiac%20MRI%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Monique%22%2C%22lastName%22%3A%22Bernard%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222025-08-26%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1002%5C%2Fjmri.70103%22%2C%22ISSN%22%3A%221522-2586%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%225Z6CVJGB%22%5D%2C%22dateModified%22%3A%222025-08-28T07%3A47%3A42Z%22%7D%7D%2C%7B%22key%22%3A%22X9EJJSKF%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22De%20Masi%20et%20al.%22%2C%22parsedDate%22%3A%222025-08-21%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BDe%20Masi%2C%20M.%2C%20Guivier-Curien%2C%20C.%2C%20Gaudry%2C%20M.%2C%20Jacquier%2C%20A.%2C%20Piquet%2C%20P.%20and%20Deplano%2C%20V.%20%282025%29%20%26%23x201C%3BGeometric%20Aortic%20Remodeling%20and%20Stent-Graft%20Migration%20After%20TEVAR%3A%20Insights%20from%20Longitudinal%203D%20Analysis%20and%20Literature%20Review%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BJournal%20of%20Personalized%20Medicine%26lt%3B%5C%2Fi%26gt%3B%2C%2015%288%29%2C%20p.%20393.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3390%5C%2Fjpm15080393%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3390%5C%2Fjpm15080393%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Geometric%20Aortic%20Remodeling%20and%20Stent-Graft%20Migration%20After%20TEVAR%3A%20Insights%20from%20Longitudinal%203D%20Analysis%20and%20Literature%20Review%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mariangela%22%2C%22lastName%22%3A%22De%20Masi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carine%22%2C%22lastName%22%3A%22Guivier-Curien%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marine%22%2C%22lastName%22%3A%22Gaudry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexis%22%2C%22lastName%22%3A%22Jacquier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philippe%22%2C%22lastName%22%3A%22Piquet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Val%5Cu00e9rie%22%2C%22lastName%22%3A%22Deplano%22%7D%5D%2C%22abstractNote%22%3A%22Background%3A%20Long-term%20follow-up%20after%20endovascular%20aortic%20repair%20%28TEVAR%29%20is%20crucial%20to%20detect%20adverse%20aortic%20remodeling%2C%20even%20with%20modern%20stent%20grafts%20offering%20enhanced%20flexibility%20and%20durability.%20Conventional%20imaging%2C%20based%20on%20diameter%20measurements%2C%20may%20fail%20to%20identify%20complications%20such%20as%20endograft%20migration.%20Methods%3A%20We%20conducted%20a%20longitudinal%203D%20geometric%20analysis%20of%20thoracic%20aortic%20and%20stent-graft%20evolution%20over%2010%20years%20in%20a%20patient%20treated%20for%20descending%20thoracic%20aortic%20aneurysm%20%28DTAA%29%20by%20endovascular%20treatment.%20A%20three-dimensional%20morphological%20analysis%20%28length%2C%20tortuosity%2C%20angulation%2C%20and%20diameter%29%20was%20carried%20out%20using%20advanced%20imaging%20software%20%28EndoSize%2C%20MATLAB%29%20to%20track%20aortic%20geometry%20and%20stent-graft%20behavior%20over%20time.%20A%20focused%20review%20of%20the%20literature%20on%20stent-graft%20migration%2C%20its%20risk%20factors%2C%20complications%2C%20and%20surveillance%20strategies%20was%20also%20performed.%20Results%3A%20This%20case%20illustrates%20how%20progressive%20geometric%20remodeling-including%20aortic%20elongation%20and%20increased%20tortuosity-can%20lead%20to%20delayed%20stent-graft%20migration%20and%20late%20type%20III%20endoleaks%2C%20with%20an%20elevated%20risk%20of%20rupture.%20The%203D%20analysis%20revealed%20early%20morphological%20changes%20that%20were%20undetectable%20using%20standard%20diameter-based%20follow-up.%20These%20observations%20are%20consistent%20with%20published%20data%20showing%20higher%20migration%20rates%20over%20time%2C%20particularly%20in%20tortuous%20anatomies.%20The%20literature%20review%20further%20emphasizes%20the%20clinical%20relevance%20of%20geometric%20surveillance%2C%20given%20the%20high%20rates%20of%20reintervention%2C%20morbidity%2C%20and%20mortality%20associated%20with%20stent-graft%20migration.%20Conclusions%3A%20This%20study%20underlines%20the%20importance%20of%20personalized%20and%20geometry-based%20surveillance%20after%20TEVAR.%20Advanced%20morphological%20assessment%20tools%20provide%20valuable%20insights%20for%20the%20early%20detection%20of%20complications%20and%20tailored%20patient%20management.%20Their%20integration%20into%20routine%20follow-up%20could%20help%20optimize%20long-term%20outcomes%20and%20prevent%20life-threatening%20events%20such%20as%20rupture.%22%2C%22date%22%3A%222025-08-21%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.3390%5C%2Fjpm15080393%22%2C%22ISSN%22%3A%222075-4426%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22KFZ6H27M%22%5D%2C%22dateModified%22%3A%222025-11-27T10%3A53%3A46Z%22%7D%7D%2C%7B%22key%22%3A%224X78A5BN%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Joppin%20et%20al.%22%2C%22parsedDate%22%3A%222025-08-20%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BJoppin%2C%20V.%2C%20Masson%2C%20C.%2C%20Bendahan%2C%20D.%20and%20Bege%2C%20T.%20%282025%29%20%26%23x201C%3BA%20review%20of%20ventral%20hernia%20biomechanics%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BJournal%20of%20the%20Mechanical%20Behavior%20of%20Biomedical%20Materials%26lt%3B%5C%2Fi%26gt%3B%2C%20173%2C%20p.%20107159.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jmbbm.2025.107159%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jmbbm.2025.107159%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22A%20review%20of%20ventral%20hernia%20biomechanics%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Victoria%22%2C%22lastName%22%3A%22Joppin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Catherine%22%2C%22lastName%22%3A%22Masson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Bendahan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thierry%22%2C%22lastName%22%3A%22Bege%22%7D%5D%2C%22abstractNote%22%3A%22Despite%20advancements%20in%20surgical%20techniques%2C%20hernia%20recurrence%20rates%20remain%20high%2C%20underscoring%20the%20need%20for%20improved%20understanding%20of%20abdominal%20wall%20behaviour.%20While%20surgeons%20are%20aware%20of%20many%20factors%20contributing%20to%20hernia%20occurrence%20%28e.g%20obesity%2C%20smoking%2C%20surgical%20technique%20or%20site%20infection%29%2C%20it%20would%20be%20of%20interest%20to%20consider%20it%20as%20a%20biomechanical%20pathology.%20Indeed%2C%20an%20abdominal%20hernia%20arises%20from%20an%20imbalance%20between%20abdominal%20wall%20deformability%20and%20applied%20forces.%20This%20review%20article%20discusses%20how%20biomechanics%20offer%20a%20quantitative%20framework%20for%20assessing%20healthy%20and%20damaged%20tissue%20behaviour%2C%20guiding%20personalised%20surgical%20strategies%20throughout%20the%20pre-%2C%20intra-%2C%20and%20post-operative%20periods.%20The%20abdominal%20wall%20is%20a%20dynamic%2C%20load-bearing%20structure%2C%20continuously%20subjected%20to%20intra-abdominal%20pressure%20and%20mechanical%20stress.%20Its%20biomechanical%20properties%2C%20including%20elasticity%20and%20resistance%20to%20loading%20forces%2C%20dictate%20its%20function%20and%20response%20to%20surgical%20intervention.%20The%20linea%20alba%20is%20the%20stiffest%20component%20experiencing%20the%20highest%20stress%2C%20while%20the%20abdominal%20wall%26%23039%3Bs%20anisotropic%20nature%20influences%20deformation%20patterns.%20Various%20experimental%20and%20computational%20methods%20enable%20biomechanical%20characterisation.%20Hernias%20represent%20mechanical%20failures%20at%20anatomical%20weak%20points.%20While%20surgeons%20qualitatively%20evaluate%20abdominal%20wall%26%23039%3Bs%20biomechanics%20by%20estimating%20deformation%20and%20closure%20forces%2C%20functional%20imaging%20%28elastography%2C%20dynamic%20acquisitions%29%20could%20provide%20objective%20biomechanical%20insights.%20Hernia%20formation%20alters%20abdominal%20wall%20biomechanics%2C%20inducing%20greater%20mobility%20and%20elasticity.%20Surgical%20repair%20fundamentally%20alters%20the%20biomechanics%20of%20the%20abdominal%20wall.%20The%20choice%20of%20defect%26%23039%3Bs%20suturing%20technique%2C%20mesh%20properties%2C%20placement%2C%20overlap%20and%20fixation%20methods%20%28e.g.%20suture%2C%20tacks%29%20significantly%20influence%20mechanical%20outcomes.%20Surgical%20repair%20tends%20to%20restore%20physiological%20biomechanics%20by%20re-establishing%20force%20transmission%20and%20hernia-induced%20excessive%20mobility.%20Suturing%20techniques%2C%20mesh%20selection%20and%20placement%20influence%20mechanical%20outcomes.%20However%2C%20optimal%20results%20require%20implants%20with%20mechanical%20properties%20mimicking%20native%20tissue.%20Lightweight%20meshes%20%28%26lt%3B70%5Cu00a0g%5C%2Fm2%29%20placed%20in%20a%20retrorectus%20position%2C%20combined%20with%20a%20small-bite%20suture%20technique%2C%20have%20been%20associated%20with%20lower%20recurrence%20rates%20and%20improved%20post-operative%20function.%20By%20bridging%20biomechanics%20with%20surgical%20practice%2C%20this%20review%20highlights%20how%20mechanical%20principles%20shape%20hernia%20formation%2C%20diagnosis%2C%20and%20repair.%20A%20deeper%20integration%20of%20biomechanical%20principles%20into%20surgical%20decision-making%20could%20refine%20hernia%20management%20and%20lead%20to%20patient-specific%2C%20mechanics-informed%20strategies.%20For%20surgeons%2C%20this%20knowledge%20is%20not%20just%20academic%20-%20it%20is%20practical%20and%20can%20make%20a%20difference%20to%20patient%20outcomes.%22%2C%22date%22%3A%222025-08-20%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.jmbbm.2025.107159%22%2C%22ISSN%22%3A%221878-0180%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22NW6SZQBR%22%5D%2C%22dateModified%22%3A%222025-09-15T13%3A07%3A58Z%22%7D%7D%2C%7B%22key%22%3A%22RJRHRZJ6%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Bouazizi%20et%20al.%22%2C%22parsedDate%22%3A%222025-08-12%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BBouazizi%2C%20K.%2C%20Yoganathan%2C%20T.%2C%20Kober%2C%20F.%2C%20Autret%2C%20G.%2C%20Marsac%2C%20P.%2C%20Delacroix%2C%20C.%2C%20Soulez%2C%20S.%2C%20Zarai%2C%20M.%2C%20Nguyen%2C%20V.%2C%20Squalli%2C%20A.%2C%20Alayrac%2C%20P.%2C%20Robidel%2C%20E.%2C%20Tavitian%2C%20B.%2C%20Redheuil%2C%20A.%2C%20Hulot%2C%20J.-S.%20and%20Kachenoura%2C%20N.%20%282025%29%20%26%23x201C%3BLeft%20ventricle%20strain%20and%20T1%20mapping%20evaluation%20in%20a%20mouse%20model%20with%20myocardial%20infarction%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BScientific%20Reports%26lt%3B%5C%2Fi%26gt%3B%2C%2015%281%29%2C%20p.%2029579.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-025-09699-0%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-025-09699-0%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Left%20ventricle%20strain%20and%20T1%20mapping%20evaluation%20in%20a%20mouse%20model%20with%20myocardial%20infarction%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Khaoula%22%2C%22lastName%22%3A%22Bouazizi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thulaciga%22%2C%22lastName%22%3A%22Yoganathan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Frank%22%2C%22lastName%22%3A%22Kober%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gwennhael%22%2C%22lastName%22%3A%22Autret%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Perrine%22%2C%22lastName%22%3A%22Marsac%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cl%5Cu00e9ment%22%2C%22lastName%22%3A%22Delacroix%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shannon%22%2C%22lastName%22%3A%22Soulez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mohamed%22%2C%22lastName%22%3A%22Zarai%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%22%2C%22lastName%22%3A%22Nguyen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Adil%22%2C%22lastName%22%3A%22Squalli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Paul%22%2C%22lastName%22%3A%22Alayrac%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Estelle%22%2C%22lastName%22%3A%22Robidel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bertrand%22%2C%22lastName%22%3A%22Tavitian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alban%22%2C%22lastName%22%3A%22Redheuil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-S%5Cu00e9bastien%22%2C%22lastName%22%3A%22Hulot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadjia%22%2C%22lastName%22%3A%22Kachenoura%22%7D%5D%2C%22abstractNote%22%3A%22Myocardial%20strain%20and%20T1%20mapping%20offer%20precise%20evaluation%20of%20cardiac%20function%20and%20tissue%20characteristics.%20The%20aim%20of%20this%20study%20is%20to%20provide%20normative%20myocardial%20strain%20and%20T1%20values%20in%20mice%20model%20along%20with%20their%20changes%20after%20myocardial%20infarction%20%28MI%29%20using%20a%20tailored%20acquisition%20and%20analysis%20protocol.%20Healthy%20mice%20had%20MRI%20before%20and%20after%20MI.%20Imaging%20was%20performed%20to%20assess%20cardiac%20function%20and%20left%20ventricle%20%28LV%29%20strain.%20A%20Look-Locker%20Inversion-Recovery%20sequence%20was%20used%20for%20T1%20maps%20reconstruction.%20Gadolinium%20doses%20and%20timing%20of%20image%20acquisitions%20were%20optimized.%20Radial%20and%20circumferential%20strain%20measurements%20were%20conducted%20using%20a%20custom%20software%20based%20on%20feature%20tracking.%20To%20address%20ECG%20signal%20interference%2C%20adjustments%20were%20made%20for%20accurate%20strain%20calculations.%20An%20LV%20dilation%20in%20MI%20compared%20to%20wild-type%20%28WT%29%20with%20a%20decrease%20in%20LV%20ejection%20fraction%20%28p%5Cu2009%26lt%3B%5Cu20090.0001%29%20were%20reported%20while%20stroke%20volume%20and%20cardiac%20output%20remained%20preserved%20%28p%5Cu2009%26gt%3B%5Cu20090.21%29.%20Normative%20strain%20and%20T1%20mapping%20data%20were%20provided%20revealing%20an%20increase%20in%20circumferential%20strain%20from%20base%20to%20apex%20%28basal%3A%20-14%5Cu2009%5Cu00b1%5Cu20091%25%2C%20mid%3A%20-15%5Cu2009%5Cu00b1%5Cu20092%25%2C%20apical%3A%20-%2021%5Cu2009%5Cu00b1%5Cu20093%25%3B%5Cu00a0p%5Cu2009%26lt%3B%5Cu20090.0001%29%20and%20notable%20differences%20in%20native%20and%20post-contrast%20T1%20values%20between%20mid-ventricular%20and%20apical%20LV%20segments.%20Circumferential%20strain%20differences%20between%20MI%20and%20WT%20mice%20were%20pronounced%2C%20with%20a%20significant%20drop%20in%20apical%20strain%20%28p%5Cu2009%26lt%3B%5Cu20090.0001%29%20in%20MI.%20Post-MI%20mice%20exhibited%20higher%20native%20T1%20and%20lower%20post-contrast%20T1%20compared%20to%20WT.%20Our%20methodological%20approach%20not%20only%20refines%20imaging%20sequences%20but%20also%20offers%20insights%20into%20cardiac%20function%20and%20tissue%20characteristics%20in%20mice.%20By%20describing%20normative%20values%20of%20strain%20and%20T1%2C%20our%20findings%20lay%20the%20groundwork%20for%20future%20research%2C%20particularly%20in%20drug%20therapy.%22%2C%22date%22%3A%222025-08-12%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41598-025-09699-0%22%2C%22ISSN%22%3A%222045-2322%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22BR9D2SS4%22%5D%2C%22dateModified%22%3A%222025-11-19T13%3A59%3A28Z%22%7D%7D%2C%7B%22key%22%3A%22T4W95BS2%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Robin%20et%20al.%22%2C%22parsedDate%22%3A%222025-08-12%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BRobin%2C%20C.%2C%20Rollot%2C%20F.%2C%20Lefort%2C%20M.%2C%20Casey%2C%20R.%2C%20Vukusic%2C%20S.%2C%20Mathey%2C%20G.%2C%20Ciron%2C%20J.%2C%20De%20Seze%2C%20J.%2C%20Stankoff%2C%20B.%2C%20Maillart%2C%20E.%2C%20Ruet%2C%20A.%2C%20Labauge%2C%20P.M.%2C%20Kwiatkowski%2C%20A.%2C%20Zephir%2C%20H.%2C%20Papeix%2C%20C.%2C%20Defer%2C%20G.%2C%20Lebrun-Frenay%2C%20C.%2C%20Moreau%2C%20T.%2C%20Laplaud%2C%20D.A.%2C%20Berger%2C%20E.%2C%20Clavelou%2C%20P.%2C%20Thouvenot%2C%20E.%2C%20Heinzlef%2C%20O.%2C%20Pelletier%2C%20J.%2C%20Casez%2C%20O.%2C%20Bourre%2C%20B.%2C%20Wahab%2C%20A.%2C%20Magy%2C%20L.%2C%20Moulin%2C%20S.%2C%20Camdessanche%2C%20J.-P.%2C%20Doghri%2C%20I.%2C%20Sarov%2C%20M.%2C%20Hankiewicz%2C%20K.%2C%20Pottier%2C%20C.%2C%20Dos%20Santos%2C%20A.%2C%20Manchon%2C%20E.%2C%20Tchikviladze%2C%20M.%2C%20Nifle%2C%20C.%2C%20Kerbrat%2C%20A.%2C%20Edan%2C%20G.%2C%20Le%20Page%2C%20E.%2C%20Michel%2C%20L.%20and%20as%20the%20OFSEP%20Investigators%20%282025%29%20%26%23x201C%3BUse%20of%20Disease-Modifying%20Therapies%20in%20Patients%20With%20Late-Onset%20Multiple%20Sclerosis%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BNeurology%26lt%3B%5C%2Fi%26gt%3B%2C%20105%283%29%2C%20p.%20e213744.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1212%5C%2FWNL.0000000000213744%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1212%5C%2FWNL.0000000000213744%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Use%20of%20Disease-Modifying%20Therapies%20in%20Patients%20With%20Late-Onset%20Multiple%20Sclerosis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Camille%22%2C%22lastName%22%3A%22Robin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabien%22%2C%22lastName%22%3A%22Rollot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mathilde%22%2C%22lastName%22%3A%22Lefort%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Romain%22%2C%22lastName%22%3A%22Casey%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sandra%22%2C%22lastName%22%3A%22Vukusic%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guillaume%22%2C%22lastName%22%3A%22Mathey%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jonathan%22%2C%22lastName%22%3A%22Ciron%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jerome%22%2C%22lastName%22%3A%22De%20Seze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruno%22%2C%22lastName%22%3A%22Stankoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elisabeth%22%2C%22lastName%22%3A%22Maillart%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aur%5Cu00e9lie%22%2C%22lastName%22%3A%22Ruet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pierre%20M.%22%2C%22lastName%22%3A%22Labauge%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Arnaud%22%2C%22lastName%22%3A%22Kwiatkowski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Helene%22%2C%22lastName%22%3A%22Zephir%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Caroline%22%2C%22lastName%22%3A%22Papeix%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gilles%22%2C%22lastName%22%3A%22Defer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christine%22%2C%22lastName%22%3A%22Lebrun-Frenay%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thibault%22%2C%22lastName%22%3A%22Moreau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%20Axel%22%2C%22lastName%22%3A%22Laplaud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%22%2C%22lastName%22%3A%22Berger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pierre%22%2C%22lastName%22%3A%22Clavelou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%22%2C%22lastName%22%3A%22Thouvenot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Olivier%22%2C%22lastName%22%3A%22Heinzlef%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean%22%2C%22lastName%22%3A%22Pelletier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Olivier%22%2C%22lastName%22%3A%22Casez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bertrand%22%2C%22lastName%22%3A%22Bourre%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Abir%22%2C%22lastName%22%3A%22Wahab%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laurent%22%2C%22lastName%22%3A%22Magy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sol%5Cu00e8ne%22%2C%22lastName%22%3A%22Moulin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Philippe%22%2C%22lastName%22%3A%22Camdessanche%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ines%22%2C%22lastName%22%3A%22Doghri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mariana%22%2C%22lastName%22%3A%22Sarov%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karolina%22%2C%22lastName%22%3A%22Hankiewicz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Corinne%22%2C%22lastName%22%3A%22Pottier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Am%5Cu00e9lie%22%2C%22lastName%22%3A%22Dos%20Santos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%22%2C%22lastName%22%3A%22Manchon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maya%22%2C%22lastName%22%3A%22Tchikviladze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chantal%22%2C%22lastName%22%3A%22Nifle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne%22%2C%22lastName%22%3A%22Kerbrat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gilles%22%2C%22lastName%22%3A%22Edan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Le%20Page%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laure%22%2C%22lastName%22%3A%22Michel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22as%20the%20OFSEP%20Investigators%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%20AND%20OBJECTIVES%3A%20The%20therapeutic%20strategy%20in%20patients%20with%20late-onset%20MS%20%28LOMS%29%20remains%20poorly%20defined.%20In%20this%20study%2C%20we%20aimed%20to%20evaluate%20both%20clinical%20and%20MRI%20outcomes%20between%202%20cohorts%20of%20patients%20with%20relapsing-remitting%20LOMS%20treated%20or%20not%20yet%20treated.%5CnMETHODS%3A%20Patients%20with%20relapsing-remitting%20MS%20were%20included%20for%20the%20analysis%20if%20disease%20onset%20occurred%20after%2055%20years%20and%20if%20they%20had%20at%20least%20one%20follow-up%20visit.%20The%20primary%20outcome%20was%20time%20to%20first%20relapse%20between%202%20matched%20groups%20of%20patients%20with%20LOMS%20%28treated%20and%20not%20yet%20treated%29.%20Secondary%20outcomes%20were%20as%20follows%3A%20%281%29%20time%20to%20first%20confirmed%20disability%20progression%20%28CDP%29%2C%20%282%29%20time%20to%20first%20progression%20independent%20of%20relapse%20activity%20%28PIRA%29%20event%2C%20%283%29%20time%20to%20secondary%20progression%20%28SPMS%29%2C%20%284%29%20time%20to%20first%20MRI%20activity%2C%20and%20%285%29%20serious%20infection%20incidence%20rates%20%28IIRs%29.%20For%20the%20comparative%20analyses%2C%20we%20adopted%20a%20time-dependent%20propensity%20score%20matching%20approach.%5CnRESULTS%3A%20A%20total%20of%20881%20patients%20fulfilled%20the%20inclusion%20criteria.%20The%20mean%20%28SD%29%20age%20at%20onset%20was%2059.9%20%284.43%29%20years.%20After%20applying%20propensity%20score%20matching%2C%20436%20patients%20were%20matched.%20The%20mean%20%28SD%29%20follow-up%20duration%20was%205.2%20%284.27%29%20years%20in%20the%20treated%20group%20and%205.0%20%283.86%29%20years%20in%20the%20not-yet-treated%20group.%20Mean%20%28SD%29%20time%20to%20first%20relapse%20was%20significantly%20longer%20in%20the%20treated%20group%20compared%20with%20the%20not-yet-treated%20group%20%287.0%20years%20%5B0.33%5D%20vs%205.4%20years%20%5B0.33%5D%3B%20p%20%3D%200.001%29.%20Mean%20%28SD%29%20time%20to%20first%20MRI%20activity%20was%20significantly%20longer%20in%20the%20treated%20group%20%285.9%20years%20%5B0.33%5D%20vs%205.0%20years%20%5B0.33%5D%3B%20p%20%3D%200.049%29.%20However%2C%20the%20mean%20time%20to%20CDP%2C%20PIRA%2C%20or%20SPMS%20was%20not%20different%20between%20the%202%20groups%20%28difference%20%3D%200.32%20years%3B%20p%20%3D%200.585%20for%20CDP%3B%20difference%20%3D%200.40%20years%3B%20p%20%3D%200.442%20for%20PIRA%3B%20difference%20%3D%20-0.02%20years%3B%20p%20%3D%200.952%20for%20SPMS%29.%20No%20increase%20in%20serious%20IIRs%20was%20observed%20with%20an%20incidence%20rate%20ratio%20of%200.38%20%2895%25%20CI%200.07-2.10%2C%20p%20%3D%200.265%29%20in%20the%20never-treated%20group%20compared%20with%20the%20treated%20one.%5CnDISCUSSION%3A%20This%20study%20demonstrates%20a%20beneficial%20effect%20of%20disease-modifying%20therapy%20%28DMT%29%20on%20disease%20activity%20in%20patients%20with%20LOMS%20but%20without%20significant%20impact%20on%20disability%20progression.%20Main%20limitations%20are%20linked%20to%20the%20challenge%20of%20data%20collection%20and%20to%20the%20baseline%20imbalances%20between%20the%202%20groups.%5CnCLASSIFICATION%20OF%20EVIDENCE%3A%20This%20study%20provides%20Class%20III%20evidence%20that%20in%20patients%20with%20LOMS%2C%20treatment%20with%20DMTs%20is%20associated%20with%20a%20longer%20time%20to%20first%20relapse%20compared%20with%20those%20not%20treated%20with%20DMTs.%22%2C%22date%22%3A%222025-08-12%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1212%5C%2FWNL.0000000000213744%22%2C%22ISSN%22%3A%221526-632X%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22B4EWFM7E%22%2C%22B2M3AZVC%22%5D%2C%22dateModified%22%3A%222025-11-19T13%3A59%3A23Z%22%7D%7D%2C%7B%22key%22%3A%22F2BXABSJ%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Gavoille%20et%20al.%22%2C%22parsedDate%22%3A%222025-08-04%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BGavoille%2C%20A.%2C%20Rollot%2C%20F.%2C%20Casey%2C%20R.%2C%20Mathey%2C%20G.%2C%20Le%20Page%2C%20E.%2C%20Ciron%2C%20J.%2C%20De%20S%26%23xE8%3Bze%2C%20J.%2C%20Ruet%2C%20A.%2C%20Maillart%2C%20E.%2C%20Labauge%2C%20P.%2C%20Zephir%2C%20H.%2C%20Kwiatkowski%2C%20A.%2C%20Papeix%2C%20C.%2C%20Defer%2C%20G.%2C%20Lebrun-Frenay%2C%20C.%2C%20Moreau%2C%20T.%2C%20Laplaud%2C%20D.-A.%2C%20Berger%2C%20E.%2C%20Dubessy%2C%20A.-L.%2C%20Clavelou%2C%20P.%2C%20Thouvenot%2C%20E.%2C%20Heinzlef%2C%20O.%2C%20Pelletier%2C%20J.%2C%20Al-Khedr%2C%20A.%2C%20Casez%2C%20O.%2C%20Bourre%2C%20B.%2C%20Wahab%2C%20A.%2C%20Magy%2C%20L.%2C%20Moulin%2C%20S.%2C%20Camdessanch%26%23xE9%3B%2C%20J.-P.%2C%20Doghri%2C%20I.%2C%20Sarov-Riviere%2C%20M.%2C%20Hankiewicz%2C%20K.%2C%20Pottier%2C%20C.%2C%20Dos%20Santos%2C%20A.%2C%20Nifle%2C%20C.%2C%20Subtil%2C%20F.%2C%20Vukusic%2C%20S.%20and%20OFSEP%20Investigators%20%282025%29%20%26%23x201C%3BTherapeutic%20Management%20During%20Pregnancy%20and%20Relapse%20Risk%20in%20Women%20With%20Multiple%20Sclerosis%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BJAMA%20neurology%26lt%3B%5C%2Fi%26gt%3B%20%5BPreprint%5D.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1001%5C%2Fjamaneurol.2025.2550%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1001%5C%2Fjamaneurol.2025.2550%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Therapeutic%20Management%20During%20Pregnancy%20and%20Relapse%20Risk%20in%20Women%20With%20Multiple%20Sclerosis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antoine%22%2C%22lastName%22%3A%22Gavoille%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabien%22%2C%22lastName%22%3A%22Rollot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Romain%22%2C%22lastName%22%3A%22Casey%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guillaume%22%2C%22lastName%22%3A%22Mathey%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Le%20Page%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jonathan%22%2C%22lastName%22%3A%22Ciron%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00e9r%5Cu00f4me%22%2C%22lastName%22%3A%22De%20S%5Cu00e8ze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aur%5Cu00e9lie%22%2C%22lastName%22%3A%22Ruet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elisabeth%22%2C%22lastName%22%3A%22Maillart%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pierre%22%2C%22lastName%22%3A%22Labauge%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22H%5Cu00e9l%5Cu00e8ne%22%2C%22lastName%22%3A%22Zephir%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Arnaud%22%2C%22lastName%22%3A%22Kwiatkowski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Caroline%22%2C%22lastName%22%3A%22Papeix%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gilles%22%2C%22lastName%22%3A%22Defer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christine%22%2C%22lastName%22%3A%22Lebrun-Frenay%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thibault%22%2C%22lastName%22%3A%22Moreau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David-Axel%22%2C%22lastName%22%3A%22Laplaud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%22%2C%22lastName%22%3A%22Berger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne-Laure%22%2C%22lastName%22%3A%22Dubessy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pierre%22%2C%22lastName%22%3A%22Clavelou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%22%2C%22lastName%22%3A%22Thouvenot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Olivier%22%2C%22lastName%22%3A%22Heinzlef%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean%22%2C%22lastName%22%3A%22Pelletier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Abdullatif%22%2C%22lastName%22%3A%22Al-Khedr%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Olivier%22%2C%22lastName%22%3A%22Casez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bertrand%22%2C%22lastName%22%3A%22Bourre%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Abir%22%2C%22lastName%22%3A%22Wahab%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laurent%22%2C%22lastName%22%3A%22Magy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sol%5Cu00e8ne%22%2C%22lastName%22%3A%22Moulin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Philippe%22%2C%22lastName%22%3A%22Camdessanch%5Cu00e9%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22In%5Cu00e8s%22%2C%22lastName%22%3A%22Doghri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mariana%22%2C%22lastName%22%3A%22Sarov-Riviere%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karolina%22%2C%22lastName%22%3A%22Hankiewicz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Corinne%22%2C%22lastName%22%3A%22Pottier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Am%5Cu00e9lie%22%2C%22lastName%22%3A%22Dos%20Santos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chantal%22%2C%22lastName%22%3A%22Nifle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabien%22%2C%22lastName%22%3A%22Subtil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sandra%22%2C%22lastName%22%3A%22Vukusic%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22OFSEP%20Investigators%22%7D%5D%2C%22abstractNote%22%3A%22IMPORTANCE%3A%20In%20women%20with%20multiple%20sclerosis%20%28MS%29%2C%20disease-modifying%20therapy%20%28DMT%29%20management%20during%20pregnancy%20might%20impact%20relapse%20risk.%5CnOBJECTIVE%3A%20To%20estimate%20the%20effect%20of%20DMT%20management%20during%20pregnancy%20on%20MS%20relapse%20rate%20and%20compare%20different%20therapeutic%20strategies.%5CnDESIGN%2C%20SETTING%2C%20AND%20PARTICIPANTS%3A%20This%20was%20a%20multicenter%20retrospective%20cohort%20study%20using%20data%20from%20January%201990%20to%20December%202023.%20Data%20were%20extracted%20in%20December%202023%20from%20the%20French%20MS%20registry.%20Among%2052%5Cu202f955%20women%20in%20the%20registry%2C%20we%20included%20pregnancies%20identified%20through%20childbirths%20in%20patients%20with%20relapsing-onset%20MS%20who%20were%20monitored%20for%20at%20least%2018%20months%20before%20delivery%20and%209%20months%20after.%20Pregnancies%20occurring%20less%20than%2018%20months%20apart%20or%20with%20missing%20month%20of%20birth%20were%20excluded.%5CnEXPOSURES%3A%20Mediation%20analysis%20was%20used%20to%20estimate%20the%20total%2C%20direct%2C%20and%20indirect%20%28mediated%20by%20DMT%20management%29%20effects%20of%20pregnancy.%20Different%20therapeutic%20strategies%20were%20compared%3A%20DMT%20interruption%2C%20switching%20to%20or%20maintaining%20interferon%20%5Cu03b2%20or%20glatiramer%20acetate%2C%20switching%20to%20or%20maintaining%20natalizumab%20until%20the%20third%20trimester%2C%20and%20switching%20to%20or%20maintaining%20intravenous%20anti-CD20%20and%20interrupting%20it%203%20months%20before%20conception.%5CnMAIN%20OUTCOMES%20AND%20MEASURES%3A%20The%20primary%20outcome%20was%20the%20annualized%20relapse%20rate%20%28ARR%29%20during%20the%20preconception%2C%20gestation%2C%20and%20postpartum%20periods.%20Within%20a%20causal%20inference%20framework%2C%20counterfactual%20ARRs%20were%20estimated%20using%20longitudinal%20g-computation%2C%20combining%20a%20random%20forest%20algorithm%20for%20predicting%20DMTs%2C%20and%20a%20mixed-effects%20Poisson%20model%20for%20relapses.%5CnRESULTS%3A%20We%20included%206341%20pregnancies%20occurring%20in%204998%20women%20%28mean%20%5BSD%5D%20age%20at%20conception%2C%2031.5%20%5B4.5%5D%20years%29.%20DMT%20management%20during%20pregnancy%20significantly%20increased%20ARR%20during%20gestation%20%28causal%20rate%20ratio%20%5BcRR%5D%2C%201.13%3B%2095%25%20CI%2C%201.06-1.22%29%20and%20postpartum%20%28cRR%2C%201.08%3B%2095%25%20CI%2C%201.01-1.16%29%20periods.%20This%20led%20to%20a%20deleterious%20total%20effect%20of%20pregnancy%20on%20ARR%2C%20particularly%20in%20women%20receiving%20natalizumab%20before%20pregnancy%20with%20prolonged%20interruption%20%28ie%2C%20interruption%20before%20the%20second%20trimester%20or%20resumption%20more%20than%203%20months%20after%20delivery%3B%20cRR%2C%202.18%3B%2095%25%20CI%2C%201.76-2.69%29%2C%20and%20in%20women%20receiving%20fingolimod%20%28cRR%2C%202.15%3B%2095%25%20CI%2C%201.60-2.93%29.%20Compared%20to%20DMT%20interruption%2C%20anti-CD20%20strategy%20was%20the%20most%20effective%20%28cRR%2C%200.38%3B%2095%25%20CI%2C%200.25-0.52%29%2C%20followed%20by%20the%20natalizumab%20strategy%20with%20short%20interruption%20%28cRR%2C%200.80%3B%2095%25%20CI%2C%200.71-0.90%29%2C%20whereas%20interferon%20%5Cu03b2%20%28cRR%2C%200.93%3B%2095%25%20CI%2C%200.86-0.99%29%20and%20glatiramer%20acetate%20strategies%20%28cRR%2C%200.91%3B%2095%25%20CI%2C%200.84-0.99%29%20were%20less%20effective.%5CnCONCLUSION%3A%20In%20this%20study%2C%20DMT%20management%20during%20pregnancy%20significantly%20increased%20relapse%20risk%2C%20particularly%20in%20patients%20receiving%20natalizumab%20with%20prolonged%20interruption%20or%20fingolimod.%20The%20strategy%20based%20on%20the%20use%20of%20anti-CD20%20before%20pregnancy%20was%20the%20most%20effective%20to%20mitigate%20this%20risk.%22%2C%22date%22%3A%222025-08-04%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1001%5C%2Fjamaneurol.2025.2550%22%2C%22ISSN%22%3A%222168-6157%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22B4EWFM7E%22%2C%22B2M3AZVC%22%5D%2C%22dateModified%22%3A%222025-11-19T13%3A59%3A25Z%22%7D%7D%2C%7B%22key%22%3A%22WE66JXHA%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Nimje%20et%20al.%22%2C%22parsedDate%22%3A%222025-08%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BNimje%2C%20S.%2C%20Arti%26%23xE8%3Bres%2C%20T.%2C%20Guye%2C%20M.%20and%20de%20Rochefort%2C%20L.%20%282025%29%20%26%23x201C%3BInsights%20on%20Scan-Specific%20Deep-Learning%20Strategies%20for%20Brain%20MRI%20Parallel%20Imaging%20Reconstruction%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BNMR%20in%20biomedicine%26lt%3B%5C%2Fi%26gt%3B%2C%2038%288%29%2C%20p.%20e70079.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fnbm.70079%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fnbm.70079%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Insights%20on%20Scan-Specific%20Deep-Learning%20Strategies%20for%20Brain%20MRI%20Parallel%20Imaging%20Reconstruction%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Swetali%22%2C%22lastName%22%3A%22Nimje%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thierry%22%2C%22lastName%22%3A%22Arti%5Cu00e8res%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maxime%22%2C%22lastName%22%3A%22Guye%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ludovic%22%2C%22lastName%22%3A%22de%20Rochefort%22%7D%5D%2C%22abstractNote%22%3A%22Scan-specific%20deep%20learning%20strategies%20have%20been%20proposed%20for%20parallel%20imaging%20reconstruction%20in%20which%20auto-calibrated%20signals%20%28ACS%29%20are%20used%20for%20training.%20Here%2C%20we%20introduce%20methods%20to%20objectively%20optimize%20architecture%20and%20training%20details.%20In%20addition%2C%20we%20introduce%20a%20new%20metric%20to%20better%20characterize%20the%20quality%20of%20the%20reconstructed%20images.%20Various%20brain%20MRI%20situations%20are%20considered.%20The%20evaluated%20models%20encompass%20single-layer%20and%20three-layer%20residual%20CNN%20architectures%20with%20real%20and%20complex%20convolutions.%20Hyperparameters%20such%20as%20the%20level%20of%20linearity%20in%20leaky%20activation%20functions%2C%20loss%20function%2C%20kernel%20sizes%20and%20depths%20are%20optimized%20using%20grid-search%20with%20K-fold%20cross%20validation.%20The%20performances%20regarding%20ACS%20reference%20size%20and%20mode%20are%20also%20evaluated.%20An%20innovative%20COrrelation-Based%20Residual%20Artifact%20Index%20%28COBRAI%29%20quantifying%20the%20level%20of%20structured%20residual%20artifacts%20is%20proposed.%20Qualitative%20and%20quantitative%20comparisons%20are%20performed%20both%20on%20the%20FastMRI%20and%20in-house%20multi-contrasts%202D%20data.%20The%20proposed%20objective%20grid-search%20strategy%20based%20on%20ACS%20successfully%20provided%20optimized%20hyperparameters%2C%20retrospectively%20validated%20by%20enhanced%20image%20quality%20metrics.%20Notably%2C%20it%20is%20shown%20that%20nonlinearities%20produce%20structured%20residual%20artifacts%2C%20and%20that%2C%20among%20the%20models%20tested%2C%20a%20three-layer%20residual%20linear%20CNN%20with%20complex%20implementation%20and%20a%20reduced%20number%20of%20parameters%20is%20more%20robust%2C%20particularly%20providing%20less%20structured%20artifacts%20with%20less%20training%20data%2C%20leading%20to%20larger%20acceleration%20rates.%20Deep-learning%20MRI%20parallel%20image%20reconstruction%20in%20the%20scan-specific%20approach%20can%20be%20optimized%20using%20grid-search%20with%20K-fold%20cross%20validation.%20It%20was%20successfully%20applied%20in%20various%202D%20brain%20MRI%20situations.%20The%20quantification%20of%20structured%20residual%20artifacts%20with%20COBRAI%20is%20a%20useful%20complementary%20characterization%20to%20state-of-the-art%20metrics%2C%20and%20it%20can%20be%20used%20to%20drive%20model%20selection.%22%2C%22date%22%3A%222025-08%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1002%5C%2Fnbm.70079%22%2C%22ISSN%22%3A%221099-1492%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22DNKN89WD%22%2C%22XTA6KS7L%22%5D%2C%22dateModified%22%3A%222025-11-19T13%3A59%3A28Z%22%7D%7D%2C%7B%22key%22%3A%22BQ9SSM9N%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Attia%20et%20al.%22%2C%22parsedDate%22%3A%222025-07-22%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BAttia%2C%20R.%2C%20Stolowy%2C%20N.%2C%20Fitoussi%2C%20R.%20and%20David%2C%20T.%20%282025%29%20%26%23x201C%3BSevere%20corneal%20flattening%20in%20bilateral%20cornea%20plana%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BJournal%20Francais%20D%26%23x2019%3Bophtalmologie%26lt%3B%5C%2Fi%26gt%3B%2C%2048%287%29%2C%20p.%20104587.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jfo.2025.104587%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jfo.2025.104587%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Severe%20corneal%20flattening%20in%20bilateral%20cornea%20plana%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%22%2C%22lastName%22%3A%22Attia%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%22%2C%22lastName%22%3A%22Stolowy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%22%2C%22lastName%22%3A%22Fitoussi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22T.%22%2C%22lastName%22%3A%22David%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222025-07-22%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.jfo.2025.104587%22%2C%22ISSN%22%3A%221773-0597%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222025-08-06T08%3A34%3A42Z%22%7D%7D%2C%7B%22key%22%3A%22MSWCDZQ9%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Abou%20Assi%20et%20al.%22%2C%22parsedDate%22%3A%222025-07%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BAbou%20Assi%2C%20A.%2C%20Armand%2C%20M.%2C%20Sart%26%23xE9%3B%2C%20C.%2C%20Tafflet%2C%20M.%2C%20Yuan%2C%20W.L.%2C%20Peyre%2C%20H.%2C%20Charles%2C%20M.-A.%2C%20Heude%2C%20B.%20and%20Bernard%2C%20J.Y.%20%282025%29%20%26%23x201C%3BPatterns%20of%20perinatal%20exposure%20to%20PUFAs%20and%20child%20neurodevelopment%3A%20evidence%20from%20Mendelian%20randomization%20using%20FADS%20cluster%20variants%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BThe%20American%20Journal%20of%20Clinical%20Nutrition%26lt%3B%5C%2Fi%26gt%3B%2C%20122%281%29%2C%20pp.%20235%26%23x2013%3B243.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.ajcnut.2025.03.014%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.ajcnut.2025.03.014%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Patterns%20of%20perinatal%20exposure%20to%20PUFAs%20and%20child%20neurodevelopment%3A%20evidence%20from%20Mendelian%20randomization%20using%20FADS%20cluster%20variants%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aline%22%2C%22lastName%22%3A%22Abou%20Assi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Martine%22%2C%22lastName%22%3A%22Armand%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Catherine%22%2C%22lastName%22%3A%22Sart%5Cu00e9%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Muriel%22%2C%22lastName%22%3A%22Tafflet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wen%20Lun%22%2C%22lastName%22%3A%22Yuan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hugo%22%2C%22lastName%22%3A%22Peyre%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marie-Aline%22%2C%22lastName%22%3A%22Charles%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Barbara%22%2C%22lastName%22%3A%22Heude%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jonathan%20Y.%22%2C%22lastName%22%3A%22Bernard%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20The%20potential%20causal%20effects%20of%20perinatal%20exposure%20to%20polyunsaturated%20fatty%20acids%20%28PUFAs%29%20on%20child%20neurodevelopment%20remains%20controversial.%5CnOBJECTIVE%3A%20To%20infer%20causation%2C%20we%20assessed%20the%20association%20of%20perinatal%20PUFA%20patterns%20and%20child%20neurodevelopment%20by%20using%20conventional%20regression%20analyses%20and%201-sample%20Mendelian%20randomization%20%28MR%29.%5CnMETHODS%3A%20Among%201096%20mother-child%20pairs%20from%20the%20French%20Etude%20des%20D%5Cu00e9terminants%20Pr%5Cu00e9-%20et%20Postnatals%20du%20D%5Cu00e9veloppement%20de%20la%20Sant%5Cu00e9%20de%20L%26%23039%3Benfant%20cohort%2C%20patterns%20of%20perinatal%20exposure%20to%20PUFAs%20were%20previously%20identified%20combining%20PUFA%20levels%20from%20maternal%20and%20cord%20erythrocytes%2C%20and%20colostrum.%20Child%20verbal%2C%20performance%2C%20and%20full-scale%20intelligence%20quotients%20%28IQs%29%20were%20assessed%20at%20ages%205-6%20y.%20Among%20maternal%20fatty%20acid%20desaturase%20%28FADS%29%20variants%20genotyped%2C%202%20candidates%2C%20rs174546%20%28FADS1%29%20and%20rs174634%20%28FADS3%29%2C%20were%20selected%2C%20as%20instrumental%20variables%2C%20for%20the%20MR%20analysis.%20The%20association%20of%20PUFA%20patterns%20with%20child%20IQ%20was%20examined%20by%20conventional%20multivariable%20linear%20regression%20and%202-stage%20least-squares%20MR%20regression.%5CnRESULTS%3A%20In%20the%20conventional%20approach%2C%20the%20first%20pattern%20%26quot%3Bhigh%20omega-3%20long-chain%20PUFAs%20%28LC-PUFAs%29%2C%20low%20omega-6%20LC-PUFAs%26quot%3B%20was%20positively%20associated%20with%20verbal%20IQ%20%5B%5Cu03b2%20%2895%25%20confidence%20interval%29%20%3D%201.24%20%280.27%2C%202.21%29%20points%20per%201%20standard%20deviation%20%28SD%29%20increase%20in%20pattern%5D%20and%20full-scale%20IQ%20%5B1.11%20%280.18%2C%202.05%29%5D.%20This%20pattern%20was%20independent%20of%20FADS%20variants%2C%20rendering%20MR%20analysis%20inapplicable.%20The%20third%20pattern%2C%20%26quot%3Bcolostrum%20LC-PUFAs%2C%26quot%3B%20was%20positively%20associated%20with%20verbal%20%5B1.11%20%280.19%2C%202.02%29%5D%2C%20performance%20%5B1.01%20%280.09%2C%201.93%29%5D%2C%20and%20full-scale%20IQ%20%5B1.13%20%280.25%2C%202.01%29%5D.%20The%20MR%20approach%2C%20based%20on%20genetic%20instruments%20strongly%20associated%20with%20the%20third%20pattern%2C%20supported%20the%20beneficial%20effect%20on%20performance%20IQ%20%5B2.93%20%280.05%2C%205.81%29%20points%20per%201%20SD%20increase%20in%20genetically%20predicted%20pattern%5D.%20The%20MR%20also%20suggested%20a%20deleterious%20effect%20of%20the%20fourth%20pattern%20%26quot%3Blinoleic%20acid%20%28LA%29%20and%20dihomo-gamma-linolenic%20acid%20%28DGLA%29%26quot%3B%20on%20performance%20IQ%20%5B-1.66%20%28-3.22%2C%20-0.09%29%5D.%5CnCONCLUSIONS%3A%20These%20findings%20supported%20the%20potential%20beneficial%20effects%20of%20perinatal%20exposure%20to%20LC-PUFAs%20on%20child%20neurodevelopment%20while%20highlighting%20possible%20adverse%20effects%20associated%20with%20exposure%20to%20LA%20and%20DGLA.%22%2C%22date%22%3A%222025-07%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.ajcnut.2025.03.014%22%2C%22ISSN%22%3A%221938-3207%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%224FPAP9R9%22%5D%2C%22dateModified%22%3A%222025-11-19T13%3A59%3A33Z%22%7D%7D%2C%7B%22key%22%3A%22XIEAXTPI%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Liu%20et%20al.%22%2C%22parsedDate%22%3A%222025-06-27%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BLiu%2C%20X.%2C%20Dhumal%2C%20D.%2C%20Santofimia-Casta%26%23xF1%3Bo%2C%20P.%2C%20Liu%2C%20J.%2C%20Casanova%2C%20M.%2C%20Garcia-Mu%26%23xF1%3Boz%2C%20A.C.%2C%20Perles-Barbacaru%2C%20T.-A.%2C%20Elkihel%2C%20A.%2C%20Zhang%2C%20W.%2C%20Roussel%2C%20T.%2C%20Galanakou%2C%20C.%2C%20Wu%2C%20J.%2C%20Zerva%2C%20E.%2C%20Dusetti%2C%20N.%2C%20Xia%2C%20Y.%2C%20Liang%2C%20X.-J.%2C%20Viola%2C%20A.%2C%20Iovanna%2C%20J.L.%20and%20Peng%2C%20L.%20%282025%29%20%26%23x201C%3BSelf-assembling%20dendrimer%20nanodrug%20formulations%20for%20decreased%20hERG-related%20toxicity%20and%20enhanced%20therapeutic%20efficacy%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BScience%20Advances%26lt%3B%5C%2Fi%26gt%3B%2C%2011%2826%29%2C%20p.%20eadu9948.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1126%5C%2Fsciadv.adu9948%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1126%5C%2Fsciadv.adu9948%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Self-assembling%20dendrimer%20nanodrug%20formulations%20for%20decreased%20hERG-related%20toxicity%20and%20enhanced%20therapeutic%20efficacy%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xi%22%2C%22lastName%22%3A%22Liu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dinesh%22%2C%22lastName%22%3A%22Dhumal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Patricia%22%2C%22lastName%22%3A%22Santofimia-Casta%5Cu00f1o%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Juan%22%2C%22lastName%22%3A%22Liu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marion%22%2C%22lastName%22%3A%22Casanova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alicia%20Comino%22%2C%22lastName%22%3A%22Garcia-Mu%5Cu00f1oz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Teodora-Adriana%22%2C%22lastName%22%3A%22Perles-Barbacaru%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Abdechakour%22%2C%22lastName%22%3A%22Elkihel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wenzheng%22%2C%22lastName%22%3A%22Zhang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tom%22%2C%22lastName%22%3A%22Roussel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christina%22%2C%22lastName%22%3A%22Galanakou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jing%22%2C%22lastName%22%3A%22Wu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eleni%22%2C%22lastName%22%3A%22Zerva%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nelson%22%2C%22lastName%22%3A%22Dusetti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yi%22%2C%22lastName%22%3A%22Xia%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xing-Jie%22%2C%22lastName%22%3A%22Liang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ang%5Cu00e8le%22%2C%22lastName%22%3A%22Viola%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Juan%20L.%22%2C%22lastName%22%3A%22Iovanna%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ling%22%2C%22lastName%22%3A%22Peng%22%7D%5D%2C%22abstractNote%22%3A%22Cardiotoxicity%2C%20especially%20human%20ether-a-go-go-related%20gene%20%28hERG%29-related%20toxicity%2C%20is%20a%20leading%20cause%20of%20drug%20failure%20or%20market%20withdrawal.%20Reducing%20hERG%20binding%20to%20obviate%20potential%20cardiac%20toxicity%20is%20crucial.%20Nanotechnology%20has%20been%20applied%20to%20drug%20delivery%20for%20reducing%20drug%20toxicity%20and%20improving%20efficacy%2C%20but%20few%20studies%20have%20addressed%20hERG-related%20cardiotoxicity.%20We%20report%20the%20use%20of%20self-assembling%20dendrimer%20nanosystems%20for%20drug%20formulation%20and%20delivery%2C%20which%20effectively%20reduced%20hERG%20binding%20and%20associated%20toxicity%20while%20promoting%20therapeutic%20efficacy.%20Specifically%2C%20these%20dendrimer%20nanosystems%20efficiently%20encapsulated%20the%20antimalarial%20drug%20chloroquine%2C%20the%20anticancer%20agent%20doxorubicin%2C%20and%20the%20NUPR1%20inhibitor%20ZZW115%2C%20all%20three%20having%20high%20affinity%20to%20hERG%20channels.%20These%20nanoformulations%20showed%20three-%20to%20eightfold%20reduced%20hERG%20binding%20affinity%2C%20which%2C%20in%20animal%20models%2C%20translated%20to%20abolished%20toxicity.%20These%20nanodrugs%20exhibited%20prolonged%20circulation%2C%20leading%20to%20enhanced%20accumulation%20at%20disease%20sites%20and%20improved%20treatment%20outcomes.%20This%20study%20highlights%20the%20potential%20of%20nanotechnology%20to%20reduce%20hERG%20binding%20and%20related%20toxicity%20while%20improving%20drug%20efficacy%2C%20offering%20valuable%20perspectives%20for%20drug%20development.%22%2C%22date%22%3A%222025-06-27%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1126%5C%2Fsciadv.adu9948%22%2C%22ISSN%22%3A%222375-2548%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22BJ2IN35K%22%2C%22QUDUANE7%22%2C%22E2YLML4H%22%5D%2C%22dateModified%22%3A%222025-11-19T13%3A59%3A31Z%22%7D%7D%2C%7B%22key%22%3A%22ZFR8JZXS%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Antoniadis%20et%20al.%22%2C%22parsedDate%22%3A%222025-06-27%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BAntoniadis%2C%20J.%2C%20Bobot%2C%20M.%2C%20Boittin%2C%20M.%2C%20Barral%2C%20P.-A.%2C%20Jacquier%2C%20A.%2C%20Kaplanski%2C%20G.%2C%20Jourde-Chiche%2C%20N.%20and%20Jarrot%2C%20P.-A.%20%282025%29%20%26%23x201C%3B%5BAbnormal%20renal%20arteriography%5D%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BLa%20Revue%20De%20Medecine%20Interne%26lt%3B%5C%2Fi%26gt%3B%2C%20pp.%20S0248-8663%2825%2900653%26%23x2013%3B8.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.revmed.2025.06.005%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.revmed.2025.06.005%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22%5BAbnormal%20renal%20arteriography%5D%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00e9r%5Cu00e9my%22%2C%22lastName%22%3A%22Antoniadis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Micka%5Cu00ebl%22%2C%22lastName%22%3A%22Bobot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Melie%22%2C%22lastName%22%3A%22Boittin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pierre-Antoine%22%2C%22lastName%22%3A%22Barral%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexis%22%2C%22lastName%22%3A%22Jacquier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gilles%22%2C%22lastName%22%3A%22Kaplanski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22No%5Cu00e9mie%22%2C%22lastName%22%3A%22Jourde-Chiche%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pierre-Andr%5Cu00e9%22%2C%22lastName%22%3A%22Jarrot%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222025-06-27%22%2C%22language%22%3A%22fre%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.revmed.2025.06.005%22%2C%22ISSN%22%3A%221768-3122%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22KFZ6H27M%22%5D%2C%22dateModified%22%3A%222025-07-02T09%3A13%3A20Z%22%7D%7D%2C%7B%22key%22%3A%22R632UBY8%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22K%5Cu00fcstner%20et%20al.%22%2C%22parsedDate%22%3A%222025-06-14%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BK%26%23xFC%3Bstner%2C%20T.%2C%20Haast%2C%20R.%2C%20Priovoulos%2C%20N.%2C%20Clement%2C%20P.%20and%20Dos%20Santos%2C%20D.P.%20%282025%29%20%26%23x201C%3BESMRMB%202025%20focus%20topic%3A%20cycle%20of%20quality-from%20concept%20to%20clinical%20and%20scientific%20impact%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BMagma%20%28New%20York%2C%20N.Y.%29%26lt%3B%5C%2Fi%26gt%3B%20%5BPreprint%5D.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs10334-025-01272-0%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs10334-025-01272-0%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22ESMRMB%202025%20focus%20topic%3A%20cycle%20of%20quality-from%20concept%20to%20clinical%20and%20scientific%20impact%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22K%5Cu00fcstner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Roy%22%2C%22lastName%22%3A%22Haast%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nikos%22%2C%22lastName%22%3A%22Priovoulos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Patricia%22%2C%22lastName%22%3A%22Clement%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniel%20Pinto%22%2C%22lastName%22%3A%22Dos%20Santos%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222025-06-14%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1007%5C%2Fs10334-025-01272-0%22%2C%22ISSN%22%3A%221352-8661%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22FBQIKF54%22%5D%2C%22dateModified%22%3A%222025-06-16T08%3A00%3A34Z%22%7D%7D%2C%7B%22key%22%3A%22ZFVS4C2I%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Mostame%20et%20al.%22%2C%22parsedDate%22%3A%222025-06-13%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BMostame%2C%20P.%2C%20Wirsich%2C%20J.%2C%20Alderson%2C%20T.%2C%20Ridley%2C%20B.%2C%20Giraud%2C%20A.-L.%2C%20Carmichael%2C%20D.W.%2C%20Vulliemoz%2C%20S.%2C%20Guye%2C%20M.%2C%20Lemieux%2C%20L.%20and%20Sadaghiani%2C%20S.%20%282025%29%20%26%23x201C%3BA%20multiplex%20of%20connectome%20trajectories%20enables%20several%20connectivity%20patterns%20in%20parallel%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BeLife%26lt%3B%5C%2Fi%26gt%3B%2C%2013%2C%20p.%20RP98777.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.7554%5C%2FeLife.98777%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.7554%5C%2FeLife.98777%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22A%20multiplex%20of%20connectome%20trajectories%20enables%20several%20connectivity%20patterns%20in%20parallel%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Parham%22%2C%22lastName%22%3A%22Mostame%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jonathan%22%2C%22lastName%22%3A%22Wirsich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Alderson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ben%22%2C%22lastName%22%3A%22Ridley%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne-Lise%22%2C%22lastName%22%3A%22Giraud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%20W.%22%2C%22lastName%22%3A%22Carmichael%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Serge%22%2C%22lastName%22%3A%22Vulliemoz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maxime%22%2C%22lastName%22%3A%22Guye%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Louis%22%2C%22lastName%22%3A%22Lemieux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sepideh%22%2C%22lastName%22%3A%22Sadaghiani%22%7D%5D%2C%22abstractNote%22%3A%22Complex%20brain%20function%20comprises%20a%20multitude%20of%20neural%20operations%20in%20parallel%20and%20often%20at%20different%20speeds.%20Each%20of%20these%20operations%20is%20carried%20out%20across%20a%20network%20of%20distributed%20brain%20regions.%20How%20multiple%20distributed%20processes%20are%20facilitated%20in%20parallel%20is%20largely%20unknown.%20We%20postulate%20that%20such%20processing%20relies%20on%20a%20multiplex%20of%20dynamic%20network%20patterns%20emerging%20in%20parallel%20but%20from%20different%20functional%20connectivity%20%28FC%29%20timescales.%20Given%20the%20dominance%20of%20inherently%20slow%20fMRI%20in%20network%20science%2C%20it%20is%20unknown%20whether%20the%20brain%20leverages%20such%20multi-timescale%20network%20dynamics.%20We%20studied%20FC%20dynamics%20concurrently%20across%20a%20breadth%20of%20timescales%20%28from%20infraslow%20to%20%5Cu03b3-range%29%20in%20rare%2C%20simultaneously%20recorded%20intracranial%20EEG%20and%20fMRI%20in%20humans%2C%20and%20source-localized%20scalp%20EEG-fMRI%20data%20in%20humans.%20We%20examined%20spatial%20and%20temporal%20convergence%20of%20connectome%20trajectories%20across%20timescales.%20%26%23039%3BSpatial%20convergence%26%23039%3B%20refers%20to%20spatially%20similar%20EEG%20and%20fMRI%20connectome%20patterns%2C%20while%20%26%23039%3Btemporal%20convergence%26%23039%3B%20signifies%20the%20more%20specific%20case%20of%20spatial%20convergence%20at%20corresponding%20timepoints%20in%20EEG%20and%20fMRI.%20We%20observed%20spatial%20convergence%20but%20temporal%20divergence%20across%20FC%20timescales%3B%20connectome%20states%20%28recurrent%20FC%20patterns%29%20with%20partial%20spatial%20similarity%20were%20found%20in%20fMRI%20and%20all%20EEG%20frequency%20bands%2C%20but%20these%20occurred%20asynchronously%20across%20FC%20timescales.%20Our%20findings%20suggest%20that%20hemodynamic%20and%20frequency-specific%20electrophysiological%20signals%2C%20while%20involving%20similar%20large-scale%20networks%2C%20represent%20functionally%20distinct%20connectome%20trajectories%20that%20operate%20at%20different%20FC%20speeds%20and%20in%20parallel.%20This%20multiplex%20is%20poised%20to%20enable%20concurrent%20connectivity%20across%20multiple%20sets%20of%20brain%20regions%20independently.%22%2C%22date%22%3A%222025-06-13%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.7554%5C%2FeLife.98777%22%2C%22ISSN%22%3A%222050-084X%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22HVJZKIZG%22%2C%22XTA6KS7L%22%5D%2C%22dateModified%22%3A%222025-11-19T13%3A59%3A21Z%22%7D%7D%2C%7B%22key%22%3A%22FEJHDH8K%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Bouleti%20et%20al.%22%2C%22parsedDate%22%3A%222025-06-13%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BBouleti%2C%20C.%2C%20Bejan-Angoulvant%2C%20T.%2C%20Servoz%2C%20C.%2C%20Carsten%2C%20E.%2C%20Genet%2C%20T.%2C%20Ternacle%2C%20J.%2C%20Deux%2C%20J.-F.%2C%20Puymirat%2C%20E.%2C%20Mousseaux%2C%20E.%2C%20Alos%2C%20B.%2C%20Garcia%2C%20R.%2C%20Bonnet%2C%20G.%2C%20Jacquier%2C%20A.%2C%20Lattuca%2C%20B.%2C%20Huttin%2C%20O.%2C%20Akodad%2C%20M.%2C%20Redheuil%2C%20A.%2C%20Angoulvant%2C%20D.%2C%20Ou%2C%20P.%20and%20MyocarditIRM%20Investigators%20%282025%29%20%26%23x201C%3BContemporary%20Epidemiology%2C%20Management%2C%20and%20In-Hospital%20Outcomes%20of%20Acute%20Myocarditis%3A%20The%20Prospective%20Multicenter%20MyocarditIRM%20Study%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BJACC.%20Heart%20failure%26lt%3B%5C%2Fi%26gt%3B%2C%2013%288%29%2C%20p.%20102492.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jchf.2025.03.038%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jchf.2025.03.038%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Contemporary%20Epidemiology%2C%20Management%2C%20and%20In-Hospital%20Outcomes%20of%20Acute%20Myocarditis%3A%20The%20Prospective%20Multicenter%20MyocarditIRM%20Study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claire%22%2C%22lastName%22%3A%22Bouleti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Theodora%22%2C%22lastName%22%3A%22Bejan-Angoulvant%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Clement%22%2C%22lastName%22%3A%22Servoz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ehmer%22%2C%22lastName%22%3A%22Carsten%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thibaud%22%2C%22lastName%22%3A%22Genet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julien%22%2C%22lastName%22%3A%22Ternacle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Fran%5Cu00e7ois%22%2C%22lastName%22%3A%22Deux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Etienne%22%2C%22lastName%22%3A%22Puymirat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elie%22%2C%22lastName%22%3A%22Mousseaux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benjamin%22%2C%22lastName%22%3A%22Alos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rodrigue%22%2C%22lastName%22%3A%22Garcia%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guillaume%22%2C%22lastName%22%3A%22Bonnet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexis%22%2C%22lastName%22%3A%22Jacquier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benoit%22%2C%22lastName%22%3A%22Lattuca%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Olivier%22%2C%22lastName%22%3A%22Huttin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mariama%22%2C%22lastName%22%3A%22Akodad%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alban%22%2C%22lastName%22%3A%22Redheuil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Denis%22%2C%22lastName%22%3A%22Angoulvant%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Phalla%22%2C%22lastName%22%3A%22Ou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22MyocarditIRM%20Investigators%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Despite%20a%20frequently%20favorable%20evolution%20during%20the%20initial%20phase%2C%20acute%20myocarditis%20%28AM%29%20remains%20associated%20with%20heart%20failure%20and%20ventricular%20arrhythmia.%20There%20are%20no%20large%20prospective%20databases%20to%20provide%20robust%20results.%5CnOBJECTIVES%3A%20The%20aim%20of%20this%20study%20was%20to%20describe%20baseline%20characteristics%2C%20real-life%20management%2C%20in-hospital%20outcomes%2C%20and%20determinants%20of%20prognosis%20in%20a%20large%20cohort%20of%20patients%20with%20AM%20admitted%20to%20cardiology%2C%20with%20a%20comparison%20of%20patients%20with%20and%20without%20initial%20severity%20criteria.%5CnMETHODS%3A%20MyocarditIRM%20%28French%20National%20Observatory%20Tracking%20Viral%20Myocarditis%3A%20Mortality%2C%20Cardiovascular%20Events%2C%20Sequels%20on%20%5BMagnetic%20Resonance%20Imaging%5D%20MRI%29%20is%20a%20multicenter%20prospective%20observational%20study%20of%20patients%20with%20AM%20confirmed%20by%20cardiac%20magnetic%20resonance.%20Patients%20initially%20admitted%20to%20the%20intensive%20care%20unit%20or%20those%20who%20died%20before%20cardiac%20magnetic%20resonance-confirmed%20diagnosis%20were%20not%20included.%5CnRESULTS%3A%20In%20total%2C%20803%20consecutive%20hospitalized%20patients%20were%20enrolled%20at%2049%20participating%20centers%20between%20May%202016%20and%20February%202019.%20The%20median%20age%20was%2031%20years%20%28Q1-Q3%3A%2023-41%20years%29%2C%20and%2082%25%20were%20men.%20Chest%20pain%20was%20the%20most%20frequent%20symptom%20%2893%25%29%2C%20and%20112%20patients%20%2814%25%29%20had%20severity%20criteria%20upon%20admission%20%28left%20ventricular%20ejection%20fraction%20%26lt%3B50%25%2C%20severe%20ventricular%20arrythmia%2C%20high-degree%20atrioventricular%20block%2C%20or%20cardiogenic%20shock%29.%20ST-segment%20elevation%20was%20observed%20in%2049%25%20of%20patients.%20Overall%2C%2064%20patients%20%288%25%29%20experienced%20in-hospital%20complications%2C%20defined%20as%20a%20composite%20of%20death%3B%20left%20ventricular%20ejection%20fraction%20%5Cu226440%25%3B%20sustained%20ventricular%20or%20supraventricular%20arrythmia%3B%20cardiogenic%20shock%3B%20and%20need%20for%20mechanical%20circulatory%20support%2C%20inotropic%20drugs%2C%20temporary%20cardiac%20pacing%2C%20pacemaker%2C%20or%20cardiac%20defibrillator%20implantation.%20Patients%20with%20severity%20criteria%20at%20admission%20were%2010%20times%20more%20likely%20to%20experience%20in-hospital%20complications.%5CnCONCLUSIONS%3A%20This%20prospective%20cohort%20represents%20the%20largest%20AM%20database%20worldwide.%20Although%20the%20recruitment%20process%20likely%20led%20to%20a%20selection%20of%20patients%20with%20lower%20risk%20AM%2C%208%25%20experienced%20in-hospital%20complications%2C%20the%20major%20prognosis%20factor%20being%20severity%20criteria%20upon%20admission.%20%28French%20National%20Observatory%20Tracking%20Viral%20Myocarditis%3A%20Mortality%2C%20Cardiovascular%20Events%2C%20Sequels%20on%20%28Magnetic%20Resonance%20Imaging%29%20MRI%3B%20NCT02717143%29.%22%2C%22date%22%3A%222025-06-13%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.jchf.2025.03.038%22%2C%22ISSN%22%3A%222213-1787%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22KFZ6H27M%22%5D%2C%22dateModified%22%3A%222025-06-16T08%3A00%3A08Z%22%7D%7D%2C%7B%22key%22%3A%22HVQM5KRK%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Jouenne%20et%20al.%22%2C%22parsedDate%22%3A%222025-06-06%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BJouenne%2C%20A.%2C%20Sourdon%2C%20J.%2C%20Varlet%2C%20I.%2C%20Vilmen%2C%20C.%2C%20Kober%2C%20F.%2C%20Landrier%2C%20J.F.%2C%20Bernard%2C%20M.%20and%20Desrois%2C%20M.%20%282025%29%20%26%23x201C%3BResveratrol%20protection%20against%20cardiac%20remodeling%20and%20ischemia-reperfusion%20injury%20associated%20with%20hepatic%20lipid%20metabolism%20ameliorations%20and%20adipose%20tissue%20autotaxin%20pathway%20inhibition%20in%20a%20diet%20induced%20prediabetic%20female%20rat%20model%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BThe%20Journal%20of%20Nutritional%20Biochemistry%26lt%3B%5C%2Fi%26gt%3B%2C%20p.%20109992.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jnutbio.2025.109992%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jnutbio.2025.109992%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Resveratrol%20protection%20against%20cardiac%20remodeling%20and%20ischemia-reperfusion%20injury%20associated%20with%20hepatic%20lipid%20metabolism%20ameliorations%20and%20adipose%20tissue%20autotaxin%20pathway%20inhibition%20in%20a%20diet%20induced%20prediabetic%20female%20rat%20model%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Jouenne%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Sourdon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22I.%22%2C%22lastName%22%3A%22Varlet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%22%2C%22lastName%22%3A%22Vilmen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22F.%22%2C%22lastName%22%3A%22Kober%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%20F.%22%2C%22lastName%22%3A%22Landrier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Bernard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Desrois%22%7D%5D%2C%22abstractNote%22%3A%22Prediabetes%20is%20associated%20with%20an%20increased%20CV%20risk%2C%20especially%20for%20women.%20Recent%20evidence%20highlights%20the%20importance%20of%20liver%20and%20adipose%20tissue%20%28AT%29%20in%20its%20stratification.%20Current%20therapeutic%20strategies%20lack%20cardioprotective%20effects%20in%20this%20context.%20We%20evaluated%20the%20cardioprotective%20effects%20of%20resveratrol%20supplementation%20versus%20diet%20intervention%20and%20their%20association%20with%20hepatic%20and%20AT%20alterations%20in%20prediabetic%20female%20rats%20submitted%20to%20a%20high-fat-high-sucrose%20diet%20%28HFS%29.%20Female%20Wistar%20rats%20were%20divided%20into%204%20groups%20fed%20for%205%20months%20with%3A%20standard%20diet%20%28CTRL%29%2C%20HFS%20diet%20%28HFS%29%2C%20HFS%20diet%20supplemented%20for%20the%20last%202%20months%20with%20resveratrol%20%28RSV%29%20or%202%20months%20of%20standard%20diet%20after%203%20months%20of%20HFS%20diet%20%28RSD%29.%20In%20vivo%20MRI%20was%20performed%20to%20study%20cardiac%20morphology%2C%20function%20and%20perfusion.%20Tolerance%20to%20ischemia-reperfusion%20%28IR%29%20injury%20was%20investigated%20ex%20vivo%20by%20a%20simultaneous%20measurement%20of%20cardiac%20function%20and%20energy%20metabolism%20with%2031P%20MRS.%20Hepatic%20steatosis%2C%20along%20with%20hepatic%20and%20AT%20lipid%20metabolism%20and%20inflammation%20gene%20expression%2C%20was%20studied.%20HFS%20induced%20glucose%20intolerance%2C%20hepatic%20steatosis%2C%20higher%20diastolic%20LV%20volume%2C%20wall%20thickness%2C%20heart%20weight%20to%20tibia%20length%20ratio%20and%20altered%20myocardial%20tolerance%20to%20IR%2C%20with%20reduced%20function%20and%20energy%20metabolism.%20Both%20approaches%20improved%20glucose%20tolerance%2C%20reduced%20hepatic%20steatosis%20with%20lipid%20oxidation%20genes%20expression%20and%20ameliorated%20myocardial%20tolerance%20to%20IR.%20However%2C%20only%20RSV%20inhibited%20deleterious%20cardiac%20remodeling%20and%20autotaxin%20AT%20expression%20and%20plasma%20levels%20induced%20by%20HFS%20diet.%20RSV%20exhibited%20better%20cardioprotection%20than%20RSD%2C%20along%20with%20decreased%20hepatic%20steatosis%20and%20AT%20derived%20ATX%2C%20suggesting%20its%20protective%20potential%20against%20early%20cardiac%20alterations%20associated%20with%20prediabetes%20and%20NAFLD.%22%2C%22date%22%3A%222025-06-06%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.jnutbio.2025.109992%22%2C%22ISSN%22%3A%221873-4847%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%227FK4UDH9%22%2C%225Z6CVJGB%22%2C%226AT58F9E%22%2C%226B37I9FA%22%2C%22BR9D2SS4%22%2C%22KUHF8SUR%22%5D%2C%22dateModified%22%3A%222025-11-19T13%3A59%3A22Z%22%7D%7D%2C%7B%22key%22%3A%22YI2Z6N8B%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Verdu-Diaz%20et%20al.%22%2C%22parsedDate%22%3A%222025-06%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BVerdu-Diaz%2C%20J.%2C%20Bolano-D%26%23xED%3Baz%2C%20C.%2C%20Gonzalez-Chamorro%2C%20A.%2C%20Fitzsimmons%2C%20S.%2C%20Warman-Chardon%2C%20J.%2C%20Kocak%2C%20G.S.%2C%20Mucida-Alvim%2C%20D.%2C%20Smith%2C%20I.C.%2C%20Vissing%2C%20J.%2C%20Poulsen%2C%20N.S.%2C%20Luo%2C%20S.%2C%20Dom%26%23xED%3Bnguez-Gonz%26%23xE1%3Blez%2C%20C.%2C%20Bermejo-Guerrero%2C%20L.%2C%20Gomez-Andres%2C%20D.%2C%20Sotoca%2C%20J.%2C%20Pichiecchio%2C%20A.%2C%20Nicolosi%2C%20S.%2C%20Monforte%2C%20M.%2C%20Brogna%2C%20C.%2C%20Mercuri%2C%20E.%2C%20Bevilacqua%2C%20J.A.%2C%20D%26%23xED%3Baz-Jara%2C%20J.%2C%20Pizarro-Galleguillos%2C%20B.%2C%20Krkoska%2C%20P.%2C%20Alonso-P%26%23xE9%3Brez%2C%20J.%2C%20Oliv%26%23xE9%3B%2C%20M.%2C%20Niks%2C%20E.H.%2C%20Kan%2C%20H.E.%2C%20Lilleker%2C%20J.%2C%20Roberts%2C%20M.%2C%20Buchignani%2C%20B.%2C%20Shin%2C%20J.%2C%20Esselin%2C%20F.%2C%20Le%20Bars%2C%20E.%2C%20Childs%2C%20A.M.%2C%20Malfatti%2C%20E.%2C%20Sarkozy%2C%20A.%2C%20Perry%2C%20L.%2C%20Sudhakar%2C%20S.%2C%20Zanoteli%2C%20E.%2C%20Di%20Pace%2C%20F.T.%2C%20Matthews%2C%20E.%2C%20Attarian%2C%20S.%2C%20Bendahan%2C%20D.%2C%20Garibaldi%2C%20M.%2C%20Fionda%2C%20L.%2C%20Alonso-Jim%26%23xE9%3Bnez%2C%20A.%2C%20Carlier%2C%20R.%2C%20Okhovat%2C%20A.A.%2C%20Nafissi%2C%20S.%2C%20Nalini%2C%20A.%2C%20Vengalil%2C%20S.%2C%20Hollingsworth%2C%20K.%2C%20Marini-Bettolo%2C%20C.%2C%20Straub%2C%20V.%2C%20Tasca%2C%20G.%2C%20Bacardit%2C%20J.%2C%20D%26%23xED%3Baz-Manera%2C%20J.%20and%20Myo%26%23x2010%3BGuide%20Consortium%20%282025%29%20%26%23x201C%3BMyo-Guide%3A%20A%20Machine%20Learning-Based%20Web%20Application%20for%20Neuromuscular%20Disease%20Diagnosis%20With%20MRI%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BJournal%20of%20Cachexia%2C%20Sarcopenia%20and%20Muscle%26lt%3B%5C%2Fi%26gt%3B%2C%2016%283%29%2C%20p.%20e13815.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjcsm.13815%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjcsm.13815%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Myo-Guide%3A%20A%20Machine%20Learning-Based%20Web%20Application%20for%20Neuromuscular%20Disease%20Diagnosis%20With%20MRI%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jose%22%2C%22lastName%22%3A%22Verdu-Diaz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carla%22%2C%22lastName%22%3A%22Bolano-D%5Cu00edaz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alejandro%22%2C%22lastName%22%3A%22Gonzalez-Chamorro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sam%22%2C%22lastName%22%3A%22Fitzsimmons%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jodi%22%2C%22lastName%22%3A%22Warman-Chardon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Goknur%20Selen%22%2C%22lastName%22%3A%22Kocak%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Debora%22%2C%22lastName%22%3A%22Mucida-Alvim%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ian%20C.%22%2C%22lastName%22%3A%22Smith%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22John%22%2C%22lastName%22%3A%22Vissing%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nanna%20Scharff%22%2C%22lastName%22%3A%22Poulsen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sushan%22%2C%22lastName%22%3A%22Luo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cristina%22%2C%22lastName%22%3A%22Dom%5Cu00ednguez-Gonz%5Cu00e1lez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laura%22%2C%22lastName%22%3A%22Bermejo-Guerrero%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Gomez-Andres%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Javier%22%2C%22lastName%22%3A%22Sotoca%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anna%22%2C%22lastName%22%3A%22Pichiecchio%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Silvia%22%2C%22lastName%22%3A%22Nicolosi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mauro%22%2C%22lastName%22%3A%22Monforte%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%22%2C%22lastName%22%3A%22Brogna%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eugenio%22%2C%22lastName%22%3A%22Mercuri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jorge%20Alfredo%22%2C%22lastName%22%3A%22Bevilacqua%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jorge%22%2C%22lastName%22%3A%22D%5Cu00edaz-Jara%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benjam%5Cu00edn%22%2C%22lastName%22%3A%22Pizarro-Galleguillos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Peter%22%2C%22lastName%22%3A%22Krkoska%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jorge%22%2C%22lastName%22%3A%22Alonso-P%5Cu00e9rez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Montse%22%2C%22lastName%22%3A%22Oliv%5Cu00e9%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Erik%20H.%22%2C%22lastName%22%3A%22Niks%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hermien%20E.%22%2C%22lastName%22%3A%22Kan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22James%22%2C%22lastName%22%3A%22Lilleker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mark%22%2C%22lastName%22%3A%22Roberts%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bianca%22%2C%22lastName%22%3A%22Buchignani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jinhong%22%2C%22lastName%22%3A%22Shin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florence%22%2C%22lastName%22%3A%22Esselin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Le%20Bars%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne%20Marie%22%2C%22lastName%22%3A%22Childs%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Edoardo%22%2C%22lastName%22%3A%22Malfatti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anna%22%2C%22lastName%22%3A%22Sarkozy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Luke%22%2C%22lastName%22%3A%22Perry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sniya%22%2C%22lastName%22%3A%22Sudhakar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Edmar%22%2C%22lastName%22%3A%22Zanoteli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Filipe%20Tupinamba%22%2C%22lastName%22%3A%22Di%20Pace%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emma%22%2C%22lastName%22%3A%22Matthews%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shahram%22%2C%22lastName%22%3A%22Attarian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Bendahan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matteo%22%2C%22lastName%22%3A%22Garibaldi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laura%22%2C%22lastName%22%3A%22Fionda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alicia%22%2C%22lastName%22%3A%22Alonso-Jim%5Cu00e9nez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robert%22%2C%22lastName%22%3A%22Carlier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ali%20Asghar%22%2C%22lastName%22%3A%22Okhovat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shahriar%22%2C%22lastName%22%3A%22Nafissi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Atchayaram%22%2C%22lastName%22%3A%22Nalini%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Seena%22%2C%22lastName%22%3A%22Vengalil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kieren%22%2C%22lastName%22%3A%22Hollingsworth%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chiara%22%2C%22lastName%22%3A%22Marini-Bettolo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Volker%22%2C%22lastName%22%3A%22Straub%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Giorgio%22%2C%22lastName%22%3A%22Tasca%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jaume%22%2C%22lastName%22%3A%22Bacardit%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jordi%22%2C%22lastName%22%3A%22D%5Cu00edaz-Manera%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Myo%5Cu2010Guide%20Consortium%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Neuromuscular%20diseases%20%28NMDs%29%20are%20rare%20disorders%20characterized%20by%20progressive%20muscle%20fibre%20loss%2C%20leading%20to%20replacement%20by%20fibrotic%20and%20fatty%20tissue%2C%20muscle%20weakness%20and%20disability.%20Early%20diagnosis%20is%20critical%20for%20therapeutic%20decisions%2C%20care%20planning%20and%20genetic%20counselling.%20Muscle%20magnetic%20resonance%20imaging%20%28MRI%29%20has%20emerged%20as%20a%20valuable%20diagnostic%20tool%20by%20identifying%20characteristic%20patterns%20of%20muscle%20involvement.%20However%2C%20the%20increasing%20complexity%20of%20these%20patterns%20complicates%20their%20interpretation%2C%20limiting%20their%20clinical%20utility.%20Additionally%2C%20multi-study%20data%20aggregation%20introduces%20heterogeneity%20challenges.%20This%20study%20presents%20a%20novel%20multi-study%20harmonization%20pipeline%20for%20muscle%20MRI%20and%20an%20AI-driven%20diagnostic%20tool%20to%20assist%20clinicians%20in%20identifying%20disease-specific%20muscle%20involvement%20patterns.%5CnMETHODS%3A%20We%20developed%20a%20preprocessing%20pipeline%20to%20standardize%20MRI%20fat%20content%20across%20datasets%2C%20minimizing%20source%20bias.%20An%20ensemble%20of%20XGBoost%20models%20was%20trained%20to%20classify%20patients%20based%20on%20intramuscular%20fat%20replacement%2C%20age%20at%20MRI%20and%20sex.%20The%20SHapley%20Additive%20exPlanations%20%28SHAP%29%20framework%20was%20adapted%20to%20analyse%20model%20predictions%20and%20identify%20disease-specific%20muscle%20involvement%20patterns.%20To%20address%20class%20imbalance%2C%20training%20and%20evaluation%20were%20conducted%20using%20class-balanced%20metrics.%20The%20model%26%23039%3Bs%20performance%20was%20compared%20against%20four%20expert%20clinicians%20using%2014%20previously%20unseen%20MRI%20scans.%5CnRESULTS%3A%20Using%20our%20harmonization%20approach%2C%20we%20curated%20a%20dataset%20of%202961%20MRI%20samples%20from%20genetically%20confirmed%20cases%20of%2020%20paediatric%20and%20adult%20NMDs.%20The%20model%20achieved%20a%20balanced%20accuracy%20of%2064.8%25%5Cu2009%5Cu00b1%5Cu20093.4%25%2C%20with%20a%20weighted%20top-3%20accuracy%20of%2084.7%25%5Cu2009%5Cu00b1%5Cu20091.8%25%20and%20top-5%20accuracy%20of%2090.2%25%5Cu2009%5Cu00b1%5Cu20092.4%25.%20It%20also%20identified%20key%20features%20relevant%20for%20differential%20diagnosis%2C%20aiding%20clinical%20decision-making.%20Compared%20to%20four%20expert%20clinicians%2C%20the%20model%20obtained%20the%20highest%20top-3%20accuracy%20%2875.0%25%5Cu2009%5Cu00b1%5Cu20094.8%25%29.%20The%20diagnostic%20tool%20has%20been%20implemented%20as%20a%20free%20web%20platform%2C%20providing%20global%20access%20to%20the%20medical%20community.%5CnCONCLUSIONS%3A%20The%20application%20of%20AI%20in%20muscle%20MRI%20for%20NMD%20diagnosis%20remains%20underexplored%20due%20to%20data%20scarcity.%20This%20study%20introduces%20a%20framework%20for%20dataset%20harmonization%2C%20enabling%20advanced%20computational%20techniques.%20Our%20findings%20demonstrate%20the%20potential%20of%20AI-based%20approaches%20to%20enhance%20differential%20diagnosis%20by%20identifying%20disease-specific%20muscle%20involvement%20patterns.%20The%20developed%20tool%20surpasses%20expert%20performance%20in%20diagnostic%20ranking%20and%20is%20accessible%20to%20clinicians%20worldwide%20via%20the%20Myo-Guide%20online%20platform.%22%2C%22date%22%3A%222025-06%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1002%5C%2Fjcsm.13815%22%2C%22ISSN%22%3A%222190-6009%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22NW6SZQBR%22%5D%2C%22dateModified%22%3A%222025-04-25T13%3A21%3A54Z%22%7D%7D%2C%7B%22key%22%3A%22WIPJYKQS%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Uher%20et%20al.%22%2C%22parsedDate%22%3A%222025-06%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BUher%2C%20D.%2C%20Drenthen%2C%20G.S.%2C%20Hoeberigs%2C%20C.M.%2C%20van%20Lanen%2C%20R.H.G.J.%2C%20Colon%2C%20A.J.%2C%20Haast%2C%20R.A.M.%2C%20van%20Kranen-Mastenbroek%2C%20V.H.J.M.%2C%20Widman%2C%20G.%2C%20Hofman%2C%20P.A.M.%2C%20Wagner%2C%20L.G.%2C%20Beckervordersandforth%2C%20J.C.%2C%20Jansen%2C%20J.F.A.%2C%20Schijns%2C%20O.E.M.G.%2C%20Backes%2C%20W.H.%20and%20ACE%20study%20group%20%282025%29%20%26%23x201C%3BThe%20role%20of%20ultra-high%20field%20MRI%20and%20image%20processing%20in%20the%20presurgical%20workup%20in%20MRI-negative%20focal%20epilepsy%3A%20A%20validated%207T%20MRI%20case%20study%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BEpilepsy%20%26amp%3B%20Behavior%20Reports%26lt%3B%5C%2Fi%26gt%3B%2C%2030%2C%20p.%20100761.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.ebr.2025.100761%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.ebr.2025.100761%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22The%20role%20of%20ultra-high%20field%20MRI%20and%20image%20processing%20in%20the%20presurgical%20workup%20in%20MRI-negative%20focal%20epilepsy%3A%20A%20validated%207T%20MRI%20case%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniel%22%2C%22lastName%22%3A%22Uher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gerhard%20S.%22%2C%22lastName%22%3A%22Drenthen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christianne%20M.%22%2C%22lastName%22%3A%22Hoeberigs%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rick%20H.%20G.%20J.%22%2C%22lastName%22%3A%22van%20Lanen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Albert%20J.%22%2C%22lastName%22%3A%22Colon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Roy%20A.%20M.%22%2C%22lastName%22%3A%22Haast%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vivianne%20H.%20J.%20M.%22%2C%22lastName%22%3A%22van%20Kranen-Mastenbroek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guido%22%2C%22lastName%22%3A%22Widman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Paul%20A.%20M.%22%2C%22lastName%22%3A%22Hofman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Louis%20G.%22%2C%22lastName%22%3A%22Wagner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jan%20C.%22%2C%22lastName%22%3A%22Beckervordersandforth%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jacobus%20F.%20A.%22%2C%22lastName%22%3A%22Jansen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Olaf%20E.%20M.%20G.%22%2C%22lastName%22%3A%22Schijns%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Walter%20H.%22%2C%22lastName%22%3A%22Backes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22ACE%20study%20group%22%7D%5D%2C%22abstractNote%22%3A%22This%20case%20study%20demonstrates%20the%20value%20of%20combined%207%5Cu00a0T%20structural%20and%20functional%20MRI%20in%20the%20presurgical%20workup%20of%20a%2024-year-old%20male%20with%20drug-resistant%20focal%20epilepsy%20who%20was%20initially%20considered%20MRI-negative%20on%20clinical%203%5Cu00a0T%20MRI.%20The%20patient%20underwent%20extensive%20presurgical%20workup%20with%207%5Cu00a0T%20MRI%2C%20magnetoencephalography%2C%20stereo-electroencephalography%2C%20and%20resection%20of%20the%20suspected%20right%20frontal%20epileptogenic%20zone.%20Histopathology%20showed%20focal%20cortical%20dysplasia%20%28FCD%29%20type%20IIb.%20The%20patient%20remained%2011%5Cu00a0months%20after%20surgery%20seizure-free.%20Retrospective%20analysis%20revealed%20that%20both%20structural%20and%20functional%207%5Cu00a0T%20MRI%20showed%20abnormalities%20within%20the%20resected%20area.%20Morphometric%20Analysis%20Program%20%28MAP18%29%20detected%20abnormalities%20on%20both%203%5Cu00a0T%20and%207%5Cu00a0T%20images.%20However%2C%20abnormalities%20were%20more%20conspicuous%20on%207%5Cu00a0T.%20Resting-state%20functional%20MRI%20metrics%2C%20particularly%20regional%20homogeneity%20and%20fractional%20amplitude%20of%20low-frequency%20fluctuations%2C%20demonstrated%20significantly%20increased%20values%20in%20both%20a%20MAP18-defined%20region%20of%20interest%20and%20the%20entire%20resected%20area%20compared%20to%20a%20healthy%20control%20group%20%28p%5Cu00a0%26lt%3B%5Cu00a00.05%29.%20However%2C%20extensive%20unspecific%20abnormalities%20were%20also%20observed%20outside%20the%20resected%20region%2C%20highlighting%20the%20importance%20of%20a%20multimodal%20approach.%20This%20case%20study%20illustrates%20that%20advanced%20image%20processing%20of%20ultra-high%20field%20structural%20and%20resting-state%20functional%20MRI%20scans%20may%20enhance%20the%20detection%20of%20subtle%20epileptogenic%20lesions%20in%20presurgical%20evaluation%2C%20potentially%20improving%20post-operative%20seizure%20outcome%20and%20associated%20quality%20of%20life.%22%2C%22date%22%3A%222025-06%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.ebr.2025.100761%22%2C%22ISSN%22%3A%222589-9864%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22FBQIKF54%22%5D%2C%22dateModified%22%3A%222025-04-03T15%3A09%3A13Z%22%7D%7D%2C%7B%22key%22%3A%22AU8EHS4W%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Joppin%20et%20al.%22%2C%22parsedDate%22%3A%222025-05-24%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BJoppin%2C%20V.%2C%20Bendahan%2C%20D.%2C%20Ahmadi%2C%20A.A.E.%2C%20Masson%2C%20C.%20and%20Bege%2C%20T.%20%282025%29%20%26%23x201C%3BBiomechanics%20of%20the%20abdominal%20wall%20before%20and%20after%20ventral%20hernia%20repair%20using%20dynamic%20MRI%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BHernia%3A%20The%20Journal%20of%20Hernias%20and%20Abdominal%20Wall%20Surgery%26lt%3B%5C%2Fi%26gt%3B%2C%2029%281%29%2C%20p.%20185.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs10029-025-03337-4%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs10029-025-03337-4%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Biomechanics%20of%20the%20abdominal%20wall%20before%20and%20after%20ventral%20hernia%20repair%20using%20dynamic%20MRI%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Victoria%22%2C%22lastName%22%3A%22Joppin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Bendahan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ahmed%20Ali%20El%22%2C%22lastName%22%3A%22Ahmadi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Catherine%22%2C%22lastName%22%3A%22Masson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thierry%22%2C%22lastName%22%3A%22Bege%22%7D%5D%2C%22abstractNote%22%3A%22PURPOSE%3A%20This%20study%20aims%20to%20investigate%20the%20use%20of%20dynamic%20MRI%20to%20assess%20abdominal%20wall%20biomechanics%20before%20and%20after%20hernia%20surgery%2C%20considering%20that%20such%20evaluations%20can%20enhance%20our%20understanding%20of%20physiopathology%20and%20contribute%20to%20reducing%20recurrence%20rates.%5CnMETHODS%3A%20Patients%20were%20assessed%20using%20dynamic%20MRI%20in%20axial%20and%20sagittal%20planes%20while%20performing%20exercises%20%28breathing%2C%20coughing%2C%20Valsalva%29%20before%20and%20after%20their%20abdominal%20hernia%20surgery%20with%20mesh%20placement.%20Rectus%20and%20lateral%20muscles%2C%20linea%20alba%2C%20viscera%20area%2C%20defect%20dimensions%20and%20hernia%20sac%20were%20contoured%20with%20semiautomatic%20process%20to%20quantify%20the%20abdominal%20wall%20biomechanical%20temporal%20modifications.%5CnRESULTS%3A%20This%20study%20enrolled%2011%20patients.%20During%20coughing%2C%20the%20axial%20area%20of%20the%20hernia%20sac%20increased%20by%20128.4%5Cu2009%5Cu00b1%5Cu2009199.2%25.%20The%20sac%20increased%20similarly%20in%20axial%20and%20sagittal%20planes%20during%20Valsalva.%20Post-surgical%20evaluations%20showed%20a%2026%25%20reduction%20in%20inter-recti%20distance%20and%20a%20lengthening%20of%20all%20muscles%20%28p%5Cu2009%5Cu2264%5Cu20090.05%29.%20The%20post-operative%20rectus%20abdominis%20thickness%20change%20was%20negatively%20correlated%20with%20defect%20width%20during%20breathing%20%28p%5Cu2009%5Cu2264%5Cu20090.05%29.%20The%20largest%20change%20in%20linea%20alba%20displacement%20was%20observed%20in%20the%20surgical%20site%20%28p%5Cu2009%3D%5Cu20090.07%29.%20Post-operatively%2C%20lateral%20muscles%20had%20a%20larger%20inward%20displacement%20during%20Valsalva%20%28p%5Cu2009%5Cu2264%5Cu20090.05%29.%20Rectus%20abdominis%20had%20a%20larger%20outward%20displacement%20during%20breathing%20%28p%5Cu2009%3D%5Cu20090.09%29%2C%20reduced%20with%20the%20mesh%20size%20%28p%5Cu2009%5Cu2264%5Cu20090.05%29.%20A%20large%20inter-individual%20variability%20was%20observed.%5CnCONCLUSION%3A%20Using%20a%20semi-automatic%20methodology%2C%20an%20in-depth%20analysis%20of%20the%20biomechanics%20of%20the%20abdominal%20wall%20was%20conducted%2C%20highlighting%20the%20importance%20of%20a%20patient-specific%20assessment.%20A%20broader%20study%20and%20consideration%20of%20recurrence%20would%20subsequently%20complete%20this%20methodological%20work.%22%2C%22date%22%3A%222025-05-24%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1007%5C%2Fs10029-025-03337-4%22%2C%22ISSN%22%3A%221248-9204%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22NW6SZQBR%22%5D%2C%22dateModified%22%3A%222025-05-27T08%3A19%3A18Z%22%7D%7D%2C%7B%22key%22%3A%226FSMP3RH%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Jacquier%20et%20al.%22%2C%22parsedDate%22%3A%222025-05-23%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BJacquier%2C%20A.%2C%20Tacher%2C%20V.%2C%20Vidal%2C%20V.%2C%20Kobeiter%2C%20H.%2C%20Luciani%2C%20A.%2C%20Boyer%2C%20L.%2C%20Soci%26%23xE9%3Bt%26%23xE9%3B%20Fran%26%23xE7%3Baise%20d%26%23x2019%3Bimagerie%20cardiovasculaire%20diagnostique%20et%20interventionnelle%20%28SFICV%29%2C%20F%26%23xE9%3Bd%26%23xE9%3Bration%20de%20radiologie%20interventionnelle%20%28FRI%29%2C%20Soci%26%23xE9%3Bt%26%23xE9%3B%20Francaise%20de%20radiologie%20%28SFR%29%20and%20Conseil%20National%20Professionnel%20de%20Radiologie%20%28G4%29%20%282025%29%20%26%23x201C%3BResponse%20to%20%26%23x2018%3B2024%20Global%20Statement%20Defining%20Interventional%20Radiology%3A%20Have%20We%20Reached%20the%20Tipping%20Point%3F%2C%26%23x2019%3B%26%23x201D%3B%20%26lt%3Bi%26gt%3BCardiovascular%20and%20Interventional%20Radiology%26lt%3B%5C%2Fi%26gt%3B%20%5BPreprint%5D.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00270-025-04049-z%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00270-025-04049-z%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Response%20to%20%5C%222024%20Global%20Statement%20Defining%20Interventional%20Radiology%3A%20Have%20We%20Reached%20the%20Tipping%20Point%3F%5C%22%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexis%22%2C%22lastName%22%3A%22Jacquier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vania%22%2C%22lastName%22%3A%22Tacher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%22%2C%22lastName%22%3A%22Vidal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hicham%22%2C%22lastName%22%3A%22Kobeiter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alain%22%2C%22lastName%22%3A%22Luciani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Louis%22%2C%22lastName%22%3A%22Boyer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Soci%5Cu00e9t%5Cu00e9%20Fran%5Cu00e7aise%20d%5Cu2019imagerie%20cardiovasculaire%20diagnostique%20et%20interventionnelle%20%28SFICV%29%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22F%5Cu00e9d%5Cu00e9ration%20de%20radiologie%20interventionnelle%20%28FRI%29%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Soci%5Cu00e9t%5Cu00e9%20Francaise%20de%20radiologie%20%28SFR%29%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Conseil%20National%20Professionnel%20de%20Radiologie%20%28G4%29%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222025-05-23%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1007%5C%2Fs00270-025-04049-z%22%2C%22ISSN%22%3A%221432-086X%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22KFZ6H27M%22%5D%2C%22dateModified%22%3A%222025-10-30T10%3A40%3A32Z%22%7D%7D%2C%7B%22key%22%3A%222BXMTS7B%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Alonso-Ortiz%20et%20al.%22%2C%22parsedDate%22%3A%222025-05-20%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BAlonso-Ortiz%2C%20E.%2C%20Papp%2C%20D.%2C%20Barry%2C%20R.L.%2C%20Po%26%23xEB%3Bti%2C%20K.%2C%20Seifert%2C%20A.C.%2C%20Gilbert%2C%20K.M.%2C%20Lopez-Rios%2C%20N.%2C%20Paska%2C%20J.%2C%20Eippert%2C%20F.%2C%20Weiskopf%2C%20N.%2C%20Beghini%2C%20L.%2C%20Graedel%2C%20N.N.%2C%20Trampel%2C%20R.%2C%20Callaghan%2C%20M.F.%2C%20Aigner%2C%20C.S.%2C%20Freund%2C%20P.%2C%20Seif%2C%20M.%2C%20Destruel%2C%20A.%2C%20Callot%2C%20V.%2C%20Vannesjo%2C%20J.%20and%20Cohen-Adad%2C%20J.%20%282025%29%20%26%23x201C%3BMulti-center%20benchmarking%20of%20cervical%20spinal%20cord%20RF%20coils%20for%207%26%23x2009%3BT%20MRI%3A%20A%20traveling%20spines%20study%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BMagnetic%20Resonance%20in%20Medicine%26lt%3B%5C%2Fi%26gt%3B%20%5BPreprint%5D.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fmrm.30551%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fmrm.30551%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Multi-center%20benchmarking%20of%20cervical%20spinal%20cord%20RF%20coils%20for%207%5Cu2009T%20MRI%3A%20A%20traveling%20spines%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eva%22%2C%22lastName%22%3A%22Alonso-Ortiz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniel%22%2C%22lastName%22%3A%22Papp%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robert%20L.%22%2C%22lastName%22%3A%22Barry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kyota%22%2C%22lastName%22%3A%22Po%5Cu00ebti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alan%20C.%22%2C%22lastName%22%3A%22Seifert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kyle%20M.%22%2C%22lastName%22%3A%22Gilbert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nibardo%22%2C%22lastName%22%3A%22Lopez-Rios%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jan%22%2C%22lastName%22%3A%22Paska%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Falk%22%2C%22lastName%22%3A%22Eippert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nikolaus%22%2C%22lastName%22%3A%22Weiskopf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laura%22%2C%22lastName%22%3A%22Beghini%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadine%20N.%22%2C%22lastName%22%3A%22Graedel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robert%22%2C%22lastName%22%3A%22Trampel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Martina%20F.%22%2C%22lastName%22%3A%22Callaghan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christoph%20S.%22%2C%22lastName%22%3A%22Aigner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Patrick%22%2C%22lastName%22%3A%22Freund%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maryam%22%2C%22lastName%22%3A%22Seif%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aur%5Cu00e9lien%22%2C%22lastName%22%3A%22Destruel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Virginie%22%2C%22lastName%22%3A%22Callot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Johanna%22%2C%22lastName%22%3A%22Vannesjo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julien%22%2C%22lastName%22%3A%22Cohen-Adad%22%7D%5D%2C%22abstractNote%22%3A%22PURPOSE%3A%20The%20depth%20within%20the%20body%2C%20small%20diameter%2C%20long%20length%2C%20and%20varying%20tissue%20surrounding%20the%20spinal%20cord%20impose%20specific%20considerations%20when%20designing%20RF%20coils.%20The%20optimal%20coil%20configuration%20for%207%5Cu2009T%20cervical%20spinal%20cord%20MRI%20is%20unknown%20and%20currently%20there%20are%20very%20few%20coil%20options.%20The%20purpose%20of%20this%20work%20was%20%281%29%20to%20establish%20a%20quality%20control%20protocol%20for%20evaluating%207%5Cu2009T%20cervical%20spinal%20cord%20coils%2C%20and%20%282%29%20to%20use%20that%20protocol%20to%20evaluate%20the%20performance%20of%20four%20different%20coil%20designs.%5CnMETHODS%3A%20Three%20healthy%20volunteers%20and%20a%20custom%20anthropomorphic%20phantom%20%28the%20traveling%20spines%20cohort%29%20were%20scanned%20at%20seven%207%5Cu2009T%20imaging%20centers%20using%20a%20common%20protocol%20and%20each%20center%26%23039%3Bs%20specific%20cervical%20spinal%20cord%20coil.%20Four%20different%20coil%20designs%20were%20tested%20%28two%20in-house%2C%20one%20Rapid%20Biomedical%2C%20and%20one%20MRI.TOOLS%20design%29.%5CnRESULTS%3A%20The%20Rapid%20Biomedical%20coil%20was%20found%20to%20have%20the%20highest%20%20%20B%201%20%2B%20%20%24%24%20%7B%5C%5Cmathrm%7BB%7D%7D_1%5E%7B%2B%7D%20%24%24%20%20efficiency%2C%20whereas%20one%20of%20the%20in-house%20designs%20%28NeuroPoly%20Lab%29%20had%20the%20highest%20SNR%20and%20the%20largest%20spinal%20cord%20coverage.%20The%20MRI.TOOLS%20coil%20had%20the%20most%20uniform%20%20%20B%201%20%2B%20%20%24%24%20%7B%5C%5Cmathrm%7BB%7D%7D_1%5E%7B%2B%7D%20%24%24%20%20profile%20along%20the%20cervical%20spinal%20cord%3B%20however%2C%20it%20was%20limited%20in%20its%20ability%20to%20provide%20the%20requested%20flip%20angles%20%28especially%20for%20larger%20individuals%29.%20The%20latter%20was%20also%20the%20case%20for%20the%20second%20in-house%20coil%20%28MSSM%29.%5CnCONCLUSION%3A%20The%20results%20of%20this%20study%20serve%20as%20a%20guide%20for%20the%20spinal%20cord%20MRI%20community%20in%20selecting%20the%20most%20suitable%20coil%20based%20on%20specific%20requirements%20and%20offer%20a%20standardized%20protocol%20for%20assessing%20future%20coils.%22%2C%22date%22%3A%222025-05-20%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1002%5C%2Fmrm.30551%22%2C%22ISSN%22%3A%221522-2594%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22ZFC2Q648%22%2C%22R8ARNQR7%22%5D%2C%22dateModified%22%3A%222025-11-19T13%3A59%3A02Z%22%7D%7D%2C%7B%22key%22%3A%22DNR3BIPC%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Mourre%20et%20al.%22%2C%22parsedDate%22%3A%222025-05-19%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BMourre%2C%20H.%2C%20Makhalova%2C%20J.%2C%20Soncin%2C%20L.%2C%20Garnier%2C%20E.%2C%20Dary%2C%20H.%2C%20Le%20Troter%2C%20A.%2C%20Haast%2C%20R.A.M.%2C%20Testud%2C%20B.%2C%20Arthuis%2C%20M.%2C%20Villalon%2C%20S.M.%2C%20Lagarde%2C%20S.%2C%20Pizzo%2C%20F.%2C%20B%26%23xE9%3Bnar%2C%20C.%2C%20Ranjeva%2C%20J.-P.%2C%20Guye%2C%20M.%20and%20Bartolomei%2C%20F.%20%282025%29%20%26%23x201C%3BNuclei-Specific%20Amygdala%20Enlargement%20Is%20Linked%20to%20Psychiatric%20Comorbidities%20in%20Drug-Resistant%20Focal%20Epilepsy%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BAnnals%20of%20Clinical%20and%20Translational%20Neurology%26lt%3B%5C%2Fi%26gt%3B%20%5BPreprint%5D.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Facn3.70071%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Facn3.70071%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Nuclei-Specific%20Amygdala%20Enlargement%20Is%20Linked%20to%20Psychiatric%20Comorbidities%20in%20Drug-Resistant%20Focal%20Epilepsy%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22H%5Cu00e9l%5Cu00e8ne%22%2C%22lastName%22%3A%22Mourre%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Makhalova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lisa%22%2C%22lastName%22%3A%22Soncin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elodie%22%2C%22lastName%22%3A%22Garnier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hugo%22%2C%22lastName%22%3A%22Dary%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Arnaud%22%2C%22lastName%22%3A%22Le%20Troter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Roy%20A.%20M.%22%2C%22lastName%22%3A%22Haast%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benoit%22%2C%22lastName%22%3A%22Testud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marie%22%2C%22lastName%22%3A%22Arthuis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Samuel%20Medina%22%2C%22lastName%22%3A%22Villalon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stanislas%22%2C%22lastName%22%3A%22Lagarde%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Francesca%22%2C%22lastName%22%3A%22Pizzo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christian%22%2C%22lastName%22%3A%22B%5Cu00e9nar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Philippe%22%2C%22lastName%22%3A%22Ranjeva%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maxime%22%2C%22lastName%22%3A%22Guye%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabrice%22%2C%22lastName%22%3A%22Bartolomei%22%7D%5D%2C%22abstractNote%22%3A%22OBJECTIVE%3A%20Amygdala%20enlargement%20has%20been%20the%20subject%20of%20controversial%20studies%20regarding%20its%20significance%20in%20terms%20of%20pathogenicity%20both%20in%20epilepsy%20and%20in%20psychiatric%20comorbidities%20such%20as%20anxiety%2C%20depression%2C%20and%20post-traumatic%20stress%20disorder.%20However%2C%20no%20causal%20link%20has%20been%20established%20in%20either%20direction%2C%20and%20the%20role%20of%20distinct%20amygdala%20nuclei%20remains%20unknown.%20We%20investigated%20volumetric%20changes%20of%20the%20amygdala%20and%20its%20nine%20main%20nuclei%20and%20their%20associations%20with%20psychiatric%20comorbidities%20in%20patients%20with%20drug-resistant%20focal%20epilepsy.%5CnMETHODS%3A%20Eighty-seven%20adult%20patients%20with%20drug-resistant%20focal%20epilepsy%2C%20available%207%5Cu2009T%20MRI%2C%20and%20completed%20standardized%20psychiatric%20assessments%20were%20included.%20Whole%20amygdala%20and%20nuclei%20volumes%20were%20quantified%20and%20compared%20to%20healthy%20controls.%20Correlations%20between%20the%20amygdala%20or%20nuclei%20volumes%20and%20psychiatric%20scores%20were%20analyzed%2C%20as%20well%20as%20the%20prevalence%20and%20severity%20of%20each%20comorbidity%20depending%20on%20the%20presence%20of%20enlargement.%5CnRESULTS%3A%20Amygdala%20enlargement%20was%20present%20in%2041%25%20of%20patients%2C%20with%20bilateral%20enlargement%20observed%20in%2030%25%20of%20these%20cases%2C%20while%20atrophy%20was%20noted%20in%202%25.%20Bilateral%20enlargement%20correlated%20with%20higher%20posttraumatic%20stress%20disorder%20and%20depression%20scores.%20Central%20nucleus%20enlargement%20was%20associated%20with%20a%20greater%20prevalence%20of%20depression%20and%20more%20severe%20anxiety.%20Bilateral%20enlargement%20of%20distinct%20nuclei%20in%20the%20basolateral%20group%20was%20linked%20to%20more%20severe%20depression%20or%20posttraumatic%20stress%20disorder.%5CnINTERPRETATION%3A%20These%20findings%20suggest%20that%20bilateral%20amygdala%20enlargement%2C%20particularly%20in%20specific%20nuclei%2C%20may%20serve%20as%20a%20morphological%20marker%20of%20psychiatric%20comorbidities%20in%20epilepsy.%20Further%20research%20is%20needed%20to%20explore%20the%20specific%20roles%20of%20amygdala%20nuclei%20in%20psycho-epileptogenesis.%22%2C%22date%22%3A%222025-05-19%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1002%5C%2Facn3.70071%22%2C%22ISSN%22%3A%222328-9503%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22UP3H3ICX%22%2C%225P5FWCR9%22%2C%22XTA6KS7L%22%2C%22FBQIKF54%22%5D%2C%22dateModified%22%3A%222025-05-27T08%3A14%3A24Z%22%7D%7D%2C%7B%22key%22%3A%22JVAXJV8N%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Plaindoux%20et%20al.%22%2C%22parsedDate%22%3A%222025-05-18%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BPlaindoux%2C%20A.%2C%20Fur%2C%20Y.L.%2C%20Courivaud%2C%20C.%2C%20Beets%2C%20C.%2C%20Samalens%2C%20L.%2C%20Valette%2C%20J.%2C%20Lemasson%2C%20B.%2C%20Barbier%2C%20E.L.%2C%20Stupar%2C%20V.%20and%20Fauvelle%2C%20F.%20%282025%29%20%26%23x201C%3BMapping%20GABA%2B%5C%2FGlx%20in%20experimental%20temporal%20lobe%20epilepsy%20using%20edited-MRSI%20at%209.4T%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BNeuroImage%26lt%3B%5C%2Fi%26gt%3B%2C%20p.%20121274.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.neuroimage.2025.121274%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.neuroimage.2025.121274%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Mapping%20GABA%2B%5C%2FGlx%20in%20experimental%20temporal%20lobe%20epilepsy%20using%20edited-MRSI%20at%209.4T%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alicia%22%2C%22lastName%22%3A%22Plaindoux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yann%20Le%22%2C%22lastName%22%3A%22Fur%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Clothilde%22%2C%22lastName%22%3A%22Courivaud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Camille%22%2C%22lastName%22%3A%22Beets%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Loan%22%2C%22lastName%22%3A%22Samalens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julien%22%2C%22lastName%22%3A%22Valette%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benjamin%22%2C%22lastName%22%3A%22Lemasson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuel%20L.%22%2C%22lastName%22%3A%22Barbier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vasile%22%2C%22lastName%22%3A%22Stupar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florence%22%2C%22lastName%22%3A%22Fauvelle%22%7D%5D%2C%22abstractNote%22%3A%22Mesial%20temporal%20lobe%20epilepsy%20%28MTLE%29%20is%20a%20common%20drug-resistant%20epilepsy%2C%20often%20requiring%20surgery%20to%20remove%20the%20epileptogenic%20zone%20%28EZ%29.%20The%20mean%20efficiency%20of%20the%20surgery%20is%2050-70%25%2C%20so%20the%20accurate%20spatial%20localization%20of%20the%20EZ%20remains%20a%20challenge.%20In%20a%20previous%20study%20from%20Hamelin%20et%20al.%20%282020%29%2C%20gamma-aminobutyric%20acid%20%28GABA%29%2C%20the%20main%20inhibitory%20neurotransmitter%2C%20was%20shown%20to%20be%20highly%20increased%20in%20the%20EZ%20of%20a%20MTLE%20mouse%20model%2C%20with%20a%20concomitant%20decrease%20of%20Glx%20%28Glutamate%5Cu202f%2B%5Cu202fglutamine%29.%20The%20authors%20proposed%20the%20GABA%5C%2FGlx%20ratio%20as%20a%20potential%20specific%20biomarker%20of%20the%20EZ.%20As%20it%20is%20the%20only%20way%20to%20measure%20GABA%20and%20Glx%20non-invasively%20in%20vivo%2C%20we%20propose%20to%20use%20Magnetic%20Resonance%20Spectroscopy%20%28MRS%29%20methods%20to%20improve%20the%20non-invasive%20localization%20of%20the%20EZ.%20Our%20study%20introduces%20an%20original%20GABA-edited%20Magnetic%20Resonance%20Spectroscopic%20Imaging%20%28MRSI%29%20method%2C%20i.e.%20the%20MEGA-LASER%20CSI%2C%20and%20the%20dedicated%20data%20processing%20pipeline%2C%20to%20map%20GABA%20and%20Glx%20in%20pre-clinical%20settings.%20The%20MEGA-LASER%20CSI%20sequence%20was%20validated%20using%20multi-compartment%20phantoms%20with%20varying%20GABA%20concentrations%2C%20demonstrating%20a%20high%20accuracy%20to%20spatially%20discriminate%20the%20different%20compartments.%20In%20vivo%20experiments%20revealed%20a%20significant%20increase%20of%20the%20GABA%2B%5C%2FGlx%20ratio%20in%20the%20EZ%20of%20epileptic%20animals%20%28n%3D30%29%20compared%20to%20SHAM%20ones%20%28n%3D15%29%2C%20strongly%20correlated%20with%20ex%20vivo%20data.%20Preliminary%20immunohistochemistry%20experiments%20revealed%20astrocytic%20localization%20of%20GAD65%20in%20the%20EZ%2C%20suggesting%20a%20shift%20in%20GABA%20synthesis%20from%20nerve%20endings%20to%20astrocytes.%20Phantom%20and%20in%20vivo%20experiments%20prove%20that%20our%20original%20workflow%20for%20GABA%20and%20Glx%20mapping%20is%20suitable%20for%20use%20in%20neuroscience%20and%20pre-clinical%20applications.%22%2C%22date%22%3A%222025-05-18%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.neuroimage.2025.121274%22%2C%22ISSN%22%3A%221095-9572%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22SVI8UJ6H%22%5D%2C%22dateModified%22%3A%222025-11-19T13%3A59%3A35Z%22%7D%7D%2C%7B%22key%22%3A%22KE4GQ8UH%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Marignier%20et%20al.%22%2C%22parsedDate%22%3A%222025-05-16%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BMarignier%2C%20R.%2C%20Villacieros-%26%23xC1%3Blvarez%2C%20J.%2C%20Espejo%2C%20C.%2C%20Arrambide%2C%20G.%2C%20Fissolo%2C%20N.%2C%20Guti%26%23xE9%3Brrez%2C%20L.%2C%20Dinoto%2C%20A.%2C%20Mulero%2C%20P.%2C%20Rubio-Flores%2C%20L.%2C%20Nieto%2C%20P.%2C%20Alcal%26%23xE1%3B%2C%20C.%2C%20Meca-Lallana%2C%20J.E.%2C%20Mart%26%23xED%3Bnez-Garcia%2C%20P.%2C%20Mill%26%23xE1%3Bn%2C%20J.%2C%20Bernard-Valnet%2C%20R.%2C%20Gonz%26%23xE1%3Blez%2C%20I.%2C%20Orv%26%23xED%3Bz%20Garc%26%23xED%3Ba%2C%20A.%2C%20Tellez%2C%20R.%2C%20Navarro%2C%20L.%2C%20Presas-Rodr%26%23xED%3Bguez%2C%20S.%2C%20Romero-Pinel%2C%20L.%2C%20Mart%26%23xED%3Bnez-Y%26%23xE9%3Blamos%2C%20S.%2C%20Cuello%2C%20J.P.%2C%20Alonso%20Torres%2C%20A.M.%2C%20Pi%26%23xF1%3Bar%2C%20R.%2C%20%26%23xC1%3Blvarez%20Bravo%2C%20G.%2C%20Benyahya%2C%20L.%2C%20Trouillet-Assant%2C%20S.%2C%20Dyon-Tafani%2C%20V.%2C%20Froment%20Tilikete%2C%20C.%2C%20Ruet%2C%20A.%2C%20Bourre%2C%20B.%2C%20Deschamps%2C%20R.%2C%20Papeix%2C%20C.%2C%20Maillart%2C%20E.%2C%20Kerschen%2C%20P.%2C%20Ayrignac%2C%20X.%2C%20Rovira%2C%20A.%2C%20Auger%2C%20C.%2C%20Audoin%2C%20B.%2C%20Montalban%2C%20X.%2C%20Tintore%2C%20M.%2C%20Mariotto%2C%20S.%20and%20Cobo-Calvo%2C%20A.%20%282025%29%20%26%23x201C%3BAssessment%20of%20neuronal%20and%20glial%20serum%20biomarkers%20in%20myelin%20oligodendrocyte%20glycoprotein%20antibody-associated%20disease%3A%20the%20MULTIMOGAD%20study%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BJournal%20of%20Neurology%2C%20Neurosurgery%2C%20and%20Psychiatry%26lt%3B%5C%2Fi%26gt%3B%2C%20p.%20jnnp-2024-335137.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fjnnp-2024-335137%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fjnnp-2024-335137%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Assessment%20of%20neuronal%20and%20glial%20serum%20biomarkers%20in%20myelin%20oligodendrocyte%20glycoprotein%20antibody-associated%20disease%3A%20the%20MULTIMOGAD%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Romain%22%2C%22lastName%22%3A%22Marignier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Javier%22%2C%22lastName%22%3A%22Villacieros-%5Cu00c1lvarez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carmen%22%2C%22lastName%22%3A%22Espejo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Georgin%22%2C%22lastName%22%3A%22Arrambide%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicol%5Cu00e1s%22%2C%22lastName%22%3A%22Fissolo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Luc%5Cu00eda%22%2C%22lastName%22%3A%22Guti%5Cu00e9rrez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alessandro%22%2C%22lastName%22%3A%22Dinoto%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Patricia%22%2C%22lastName%22%3A%22Mulero%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laura%22%2C%22lastName%22%3A%22Rubio-Flores%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pablo%22%2C%22lastName%22%3A%22Nieto%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carmen%22%2C%22lastName%22%3A%22Alcal%5Cu00e1%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jose%20E.%22%2C%22lastName%22%3A%22Meca-Lallana%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pedro%22%2C%22lastName%22%3A%22Mart%5Cu00ednez-Garcia%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jorge%22%2C%22lastName%22%3A%22Mill%5Cu00e1n%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rapha%5Cu00ebl%22%2C%22lastName%22%3A%22Bernard-Valnet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22In%5Cu00e9s%22%2C%22lastName%22%3A%22Gonz%5Cu00e1lez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aida%22%2C%22lastName%22%3A%22Orv%5Cu00edz%20Garc%5Cu00eda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Raquel%22%2C%22lastName%22%3A%22Tellez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laura%22%2C%22lastName%22%3A%22Navarro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Silvia%22%2C%22lastName%22%3A%22Presas-Rodr%5Cu00edguez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Luc%5Cu00eda%22%2C%22lastName%22%3A%22Romero-Pinel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sergio%22%2C%22lastName%22%3A%22Mart%5Cu00ednez-Y%5Cu00e9lamos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Juan%20Pablo%22%2C%22lastName%22%3A%22Cuello%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ana%20Maria%22%2C%22lastName%22%3A%22Alonso%20Torres%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Raquel%22%2C%22lastName%22%3A%22Pi%5Cu00f1ar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gary%22%2C%22lastName%22%3A%22%5Cu00c1lvarez%20Bravo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lakhdar%22%2C%22lastName%22%3A%22Benyahya%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sophie%22%2C%22lastName%22%3A%22Trouillet-Assant%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Virginie%22%2C%22lastName%22%3A%22Dyon-Tafani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Caroline%22%2C%22lastName%22%3A%22Froment%20Tilikete%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aurelie%22%2C%22lastName%22%3A%22Ruet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bertrand%22%2C%22lastName%22%3A%22Bourre%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Romain%22%2C%22lastName%22%3A%22Deschamps%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Caroline%22%2C%22lastName%22%3A%22Papeix%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elisabeth%22%2C%22lastName%22%3A%22Maillart%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philippe%22%2C%22lastName%22%3A%22Kerschen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xavier%22%2C%22lastName%22%3A%22Ayrignac%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alex%22%2C%22lastName%22%3A%22Rovira%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cristina%22%2C%22lastName%22%3A%22Auger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bertrand%22%2C%22lastName%22%3A%22Audoin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xavier%22%2C%22lastName%22%3A%22Montalban%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mar%22%2C%22lastName%22%3A%22Tintore%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sara%22%2C%22lastName%22%3A%22Mariotto%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alvaro%22%2C%22lastName%22%3A%22Cobo-Calvo%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Serum%20neurofilament%20light%20chain%20%28sNfL%29%20and%20serum%20glial%20fibrillary%20acidic%20protein%20%28sGFAP%29%20have%20emerged%20as%20important%20biomarkers%20in%20multiple%20sclerosis%20%28MS%29%20and%20aquaporin-4%20seropositive%20neuromyelitis%20optica%20spectrum%20disorder%20%28AQP4-NMOSD%29.%20However%2C%20their%20interest%20in%20myelin%20oligodendrocyte%20glycoprotein%20antibody-associated%20disease%20%28MOGAD%29%20remains%20unclear.%20Our%20aim%20was%20to%20characterise%20sNfL%20and%20sGFAP%20profile%20and%20analyse%20their%20usefulness%20in%20predicting%20relapses%20and%20disability%20in%20MOGAD.%5CnMETHODS%3A%20Retrospective%20study%20of%20adult%20MOGAD%20patients%20with%20serum%20samples%20collected%20at%20baseline%20%28%5Cu22643%20months%20from%20disease%20onset%29%20and%20follow-up%20%28%26gt%3B6%20months%20from%20baseline%20sample%29.%20sNfL%20and%20sGFAP%20were%20analysed%20using%20Simoa%20HD-1%2C%20and%20values%20were%20compared%20across%20time-points.%20The%20association%20between%20biomarkers%20and%20clinical%20variables%20and%20their%20predictive%20value%20for%20disability%20and%20relapses%20were%20analysed.%5CnRESULTS%3A%20Eighty-nine%20MOGAD%20patients%20were%20included.%20Baseline%20sNfL%20and%20sGFAP%20values%20were%20high%20at%20baseline%20and%20decreased%20over%20time%20%28p%26lt%3B0.001%2C%20p%3D0.027%2C%20respectively%29.%20sNfL%20and%20sGFAP%20values%20were%20associated%20with%20Expanded%20Disability%20Status%20Scale%20%28EDSS%29%20at%20attacks%20%28%5Cu03b2%200.15%20%280.06%3B%200.25%29%2C%20p%3D0.002%3B%20%5Cu03b2%200.14%20%280.07%3B%200.21%29%2C%20p%26lt%3B0.001%2C%20respectively%29%20and%20were%20lower%20in%20optic%20neuritis%20presentations%20%28%5Cu03b2%20-0.69%20%28-1.18%3B%20-0.19%29%2C%20p%3D0.007%3B%20%5Cu03b2%20-0.42%20%28-0.76%3B%20-0.08%29%2C%20p%3D0.016%29.%20Biomarker%20deltas%5B%5Cu0394%5D%20%28baseline%20values%20-%20second%20samples%20values%29%20were%20associated%20with%20%5Cu0394EDSS%20%28initial%20EDSS%20-%20final%20EDSS%29%20%28%5Cu0394sNfL%20%5Cu03b2%200.52%20%280.01%3B%201.04%29%2C%20p%3D0.046%3B%20%5Cu0394sGFAP%20%5Cu03b2%201.07%20%280.38%3B%201.75%29%2C%20p%3D0.003%29.%20Finally%2C%20sNfL%20values%20independently%20predicted%20the%20risk%20of%20relapses%20%28HR%202.06%20%281.41%3B%203.01%29%2C%20p%26lt%3B0.001%29.%5CnCONCLUSIONS%3A%20Our%20results%20on%20sNfL%20and%20sGFAP%20suggest%20initial%20neuro-axonal%20and%20astrocytic%20damage%20in%20MOGAD%20and%20the%20utility%20of%20these%20biomarkers%20at%20onset%20and%20follow-up%20in%20predicting%20clinical%20recovery%20and%20relapses.%22%2C%22date%22%3A%222025-05-16%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1136%5C%2Fjnnp-2024-335137%22%2C%22ISSN%22%3A%221468-330X%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%226KPLZTET%22%5D%2C%22dateModified%22%3A%222025-11-19T13%3A59%3A20Z%22%7D%7D%2C%7B%22key%22%3A%22XVGGM5PL%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Cohen%20et%20al.%22%2C%22parsedDate%22%3A%222025-05%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BCohen%2C%20M.%2C%20Rollot%2C%20F.%2C%20Debouverie%2C%20M.%2C%20Zephir%2C%20H.%2C%20Vukusic%2C%20S.%2C%20De%20Seze%2C%20J.%2C%20Labauge%2C%20P.%2C%20Landes-Chateau%2C%20C.%2C%20Mondot%2C%20L.%2C%20Levraut%2C%20M.%2C%20Ruet%2C%20A.%2C%20Berger%2C%20E.%2C%20Laplaud%2C%20D.%2C%20Ciron%2C%20J.%2C%20Bourre%2C%20B.%2C%20Le%20Page%2C%20E.%2C%20Papeix%2C%20C.%2C%20Thouvenot%2C%20E.%2C%20Al%20Khedr%2C%20A.%2C%20Stankoff%2C%20B.%2C%20Pelletier%2C%20J.%2C%20Maillart%2C%20E.%2C%20Casez%2C%20O.%2C%20Moreau%2C%20T.%2C%20Defer%2C%20G.%2C%20Clavelou%2C%20P.%2C%20Cabre%2C%20P.%2C%20Moulin%2C%20S.%2C%20Neau%2C%20J.P.%2C%20Zedet%2C%20M.%2C%20Hankiewicz%2C%20K.%2C%20Doghri%2C%20I.%2C%20Nasr%2C%20H.B.%2C%20Pottier%2C%20C.%2C%20Magy%2C%20L.%2C%20Boulos%2C%20D.D.%2C%20Heinzlef%2C%20O.%2C%20Camdessanche%2C%20J.P.%2C%20Coustans%2C%20M.%2C%20Nifle%2C%20C.%2C%20Brassat%2C%20D.%2C%20Casey%2C%20R.%2C%20Lebrun-Frenay%2C%20C.%20and%20OFSEP%20and%20SFSEP%20study%20groups%20%282025%29%20%26%23x201C%3BSecondary%20progression%20activity%20monitoring%20in%20MS%20despite%20an%20early%20highly%20active%20treatment%20the%20SPAM%20study%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BEuropean%20Journal%20of%20Neurology%26lt%3B%5C%2Fi%26gt%3B%2C%2032%285%29%2C%20p.%20e16583.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fene.16583%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fene.16583%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Secondary%20progression%20activity%20monitoring%20in%20MS%20despite%20an%20early%20highly%20active%20treatment%20the%20SPAM%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mikael%22%2C%22lastName%22%3A%22Cohen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabien%22%2C%22lastName%22%3A%22Rollot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marc%22%2C%22lastName%22%3A%22Debouverie%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22H%5Cu00e9l%5Cu00e8ne%22%2C%22lastName%22%3A%22Zephir%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sandra%22%2C%22lastName%22%3A%22Vukusic%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00e9rome%22%2C%22lastName%22%3A%22De%20Seze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pierre%22%2C%22lastName%22%3A%22Labauge%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cassandre%22%2C%22lastName%22%3A%22Landes-Chateau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lydiane%22%2C%22lastName%22%3A%22Mondot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Levraut%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aur%5Cu00e9lie%22%2C%22lastName%22%3A%22Ruet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%22%2C%22lastName%22%3A%22Berger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Laplaud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jonathan%22%2C%22lastName%22%3A%22Ciron%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bertrand%22%2C%22lastName%22%3A%22Bourre%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Le%20Page%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Caroline%22%2C%22lastName%22%3A%22Papeix%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%22%2C%22lastName%22%3A%22Thouvenot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Abdullatif%22%2C%22lastName%22%3A%22Al%20Khedr%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruno%22%2C%22lastName%22%3A%22Stankoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean%22%2C%22lastName%22%3A%22Pelletier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elisabeth%22%2C%22lastName%22%3A%22Maillart%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Olivier%22%2C%22lastName%22%3A%22Casez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thibault%22%2C%22lastName%22%3A%22Moreau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gilles%22%2C%22lastName%22%3A%22Defer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pierre%22%2C%22lastName%22%3A%22Clavelou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philippe%22%2C%22lastName%22%3A%22Cabre%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sol%5Cu00e8ne%22%2C%22lastName%22%3A%22Moulin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean%20Philippe%22%2C%22lastName%22%3A%22Neau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mickael%22%2C%22lastName%22%3A%22Zedet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karolina%22%2C%22lastName%22%3A%22Hankiewicz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22In%5Cu00e8s%22%2C%22lastName%22%3A%22Doghri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Haifa%20Ben%22%2C%22lastName%22%3A%22Nasr%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Corinne%22%2C%22lastName%22%3A%22Pottier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laurent%22%2C%22lastName%22%3A%22Magy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dalia%20Dimitri%22%2C%22lastName%22%3A%22Boulos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Olivier%22%2C%22lastName%22%3A%22Heinzlef%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean%20Philippe%22%2C%22lastName%22%3A%22Camdessanche%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marc%22%2C%22lastName%22%3A%22Coustans%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chantal%22%2C%22lastName%22%3A%22Nifle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Brassat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Romain%22%2C%22lastName%22%3A%22Casey%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christine%22%2C%22lastName%22%3A%22Lebrun-Frenay%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22OFSEP%20and%20SFSEP%20study%20groups%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Real-world%20data%20suggest%20that%20the%20early%20use%20of%20highly%20active%20therapies%20%28HAT%29%20may%20reduce%20the%20risk%20of%20transition%20to%20secondary%20progressive%20MS%20%28SPMS%29.%20However%2C%20current%20knowledge%20about%20predictive%20factors%20of%20outcomes%20needs%20to%20be%20improved.%20The%20primary%20objective%20of%20this%20study%20was%20to%20determine%20factors%20associated%20with%20the%20occurrence%20of%20SPMS%20in%20patients%20treated%20early%20after%20MS%20onset%20with%20an%20HAT.%5CnMETHODS%3A%20Retrospective%2C%20multicentric%20study%20based%20on%20the%20French%20MS%20database.%20Patients%20who%20initiated%20a%20HAT%20within%205%5Cu2009years%20after%20MS%20onset%2C%20EDSS%20%5Cu2a7d4%2C%20and%20had%20a%20follow-up%20%26gt%3B5%5Cu2009years%20were%20included.%20The%20association%20of%20each%20covariate%20at%20baseline%20with%20time%20to%20the%20occurrence%20of%20SPMS%20was%20quantified%20by%20hazard%20ratios%20%28HRs%29%20in%20unadjusted%20and%20adjusted%20Cox%20proportional%20hazards%20models.%5CnRESULTS%3A%20Two%20thousand%20two%20hundred%20and%20thirty-seven%20patients%20were%20included%20in%20the%20analysis%3A%20mean%20age%2031.6%5Cu2009years%2C%20female%5C%2Fmale%20sex%20ratio%202.3%2C%20and%20median%20EDSS%202.0.%20The%20estimated%20probability%20of%20reaching%20SPMS%2C%20progression%20independent%20of%20relapse%20activity%20%28PIRA%29%20and%20progression%20independent%20of%20activity%20%28PIA%29%20at%2010%5Cu2009years%20was%208%25%2C%2022%25%2C%20and%2011%25%2C%20respectively.%20After%20adjustment%2C%20we%20found%20that%20female%20patients%20%28HR%200.64%2C%20p%5Cu2009%3D%5Cu20090.036%29%20had%20a%20lower%20risk%20of%20developing%20SPMS.%20Older%20age%2C%20EDSS%20%26gt%3B0%20%28HR%207.44%2C%20p%5Cu2009%26lt%3B%5Cu20090.001%29%2C%20and%20oral%20versus%20intravenous%20HAT%20%28HR%201.97%2C%20p%5Cu2009%3D%5Cu20090.003%29%20were%20significantly%20associated%20with%20an%20increased%20SPMS%20risk.%20Early%20PIRA%20and%20PIA%20predicted%20conversion%20to%20SPMS.%5CnCONCLUSIONS%3A%20Early%20HAT%20use%20resulted%20in%20a%20low%20risk%20of%20developing%20SPMS%20over%2010%5Cu2009years.%20Introducing%20the%20HAT%20before%20any%20residual%20disability%20was%20associated%20with%20a%20lower%20risk%20of%20progression.%22%2C%22date%22%3A%222025-05%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1111%5C%2Fene.16583%22%2C%22ISSN%22%3A%221468-1331%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22B2M3AZVC%22%5D%2C%22dateModified%22%3A%222025-11-19T13%3A59%3A17Z%22%7D%7D%2C%7B%22key%22%3A%22YCW6SA77%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Cotinat%20et%20al.%22%2C%22parsedDate%22%3A%222025-05%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BCotinat%2C%20M.%2C%20Messaoudi%2C%20N.%2C%20Robinet%2C%20E.%2C%20Suissa%2C%20L.%2C%20Doche%2C%20E.%2C%20Guye%2C%20M.%2C%20Audoin%2C%20B.%2C%20Bensoussan%2C%20L.%2C%20Ranjeva%2C%20J.-P.%20and%20Zaaraoui%2C%20W.%20%282025%29%20%26%23x201C%3BDynamics%20of%20Ionic%20and%20Cytotoxic%20Edema%20During%20Acute%20and%20Subacute%20Stages%20of%20Patients%20With%20Ischemic%20Stroke%3A%20Complementarity%20of%2023Na%20MRI%20and%20Diffusion%20MRI%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BNMR%20in%20biomedicine%26lt%3B%5C%2Fi%26gt%3B%2C%2038%285%29%2C%20p.%20e70028.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fnbm.70028%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fnbm.70028%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Dynamics%20of%20Ionic%20and%20Cytotoxic%20Edema%20During%20Acute%20and%20Subacute%20Stages%20of%20Patients%20With%20Ischemic%20Stroke%3A%20Complementarity%20of%2023Na%20MRI%20and%20Diffusion%20MRI%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ma%5Cu00ebva%22%2C%22lastName%22%3A%22Cotinat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22No%5Cu00eblle%22%2C%22lastName%22%3A%22Messaoudi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Robinet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laurent%22%2C%22lastName%22%3A%22Suissa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emilie%22%2C%22lastName%22%3A%22Doche%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maxime%22%2C%22lastName%22%3A%22Guye%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bertrand%22%2C%22lastName%22%3A%22Audoin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laurent%22%2C%22lastName%22%3A%22Bensoussan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Philippe%22%2C%22lastName%22%3A%22Ranjeva%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wafaa%22%2C%22lastName%22%3A%22Zaaraoui%22%7D%5D%2C%22abstractNote%22%3A%22Cerebral%20imaging%20is%20crucial%20in%20the%20diagnosis%20and%20treatment%20algorithm%20of%20acute%20stroke%20to%20determine%20salvageable%20brain%20tissue.%20While%20diffusion%20MRI%20is%20commonly%20used%20to%20define%20the%20ischemic%20core%2C%20it%20cannot%20reliably%20distinguish%20irreversibly%20damaged%20from%20salvageable%20tissue.%20We%20investigated%20the%20added%20value%20of%2023Na%20MRI%20to%20define%20irreversible%20necrotic%20tissue%20after%20a%20stroke.%20Fifteen%20patients%20with%20acute%20stroke%20involving%20medial%20cerebral%20artery%20occlusion%20were%20longitudinally%20explored%20with%20conventional%20and%2023Na%20MRI%20within%2024%5Cu2009h%2C%2070%5Cu2009h%20following%20stroke%20and%20at%203%5Cu2009months%20to%20characterize%20the%20necrotic%20area.%20Time-courses%20of%20sodium%20accumulations%20were%20observed%20within%20regions%20presenting%20with%20or%20spared%20by%20cytotoxic%5C%2Fionic%20edema%20and%20converting%20or%20not%20to%20necrosis.%20Dynamics%20of%20sodium%20accumulations%20were%20very%20different%20across%20subjects.%20At%20the%20group%20level%2C%20time-courses%20of%20sodium%20signal%20in%20cytotoxic%20edema%20showed%20a%20non-linear%20increase%20with%20an%20upper%20asymptote%20of%2059%5Cu2009%5Cu00b1%5Cu20096%25%25%20relative%20to%20the%20contralateral%20hemisphere.%20Regions%20with%20a%20larger%20early%20increase%20in%2023Na%20signal%20%28ionic%20edema%29%20showed%20a%20non-linear%20accumulation%20during%20the%20first%2070%5Cu2009h%20and%20were%20associated%20with%20subsequent%20necrosis%20at%20month%203.%20Some%20of%20the%20regions%20with%20no%20ionic%20edema%20during%20the%20first%2070%5Cu2009h%20became%20necrotic%20at%20month%203%2C%20showing%20that%20pejorative%20pathophysiological%20processes%20could%20worsen%20after%2070%5Cu2009h%20following%20attack.%20Final%20necrotic%20volume%20was%20well%20predicted%20by%20the%20cytotoxic%20volume%20%28ADC%20decrease%29%20during%20the%20first%2024%5Cu2009h%2C%20and%20by%20the%20volume%20of%20ionic%20edema%20during%20the%20subacute%20period%20%2825-70%5Cu2009h%29%20following%20attack.%20The%20regions%20showing%20ionic%20edema%20showed%20a%20non-linear%20increase%20of%2023Na%20signal%20during%20the%20first%2070%5Cu2009h%2C%20with%20larger%20sodium%20accumulations%20in%20regions%20converting%20to%20necrosis%20at%20month%203.%20It%20may%20be%20of%20interest%20to%20consider%20the%20role%20of%20ionic%20edema%20imaging%20in%20the%2070%5Cu2009h%20after%20stroke%20and%20reperfusion%2C%20with%20a%20view%20to%20better%20understand%20stroke%20pathophysiology.%20Sodium%20MRI%20could%20add%20complementary%20information%20about%20the%20fate%20of%20cell%20necrosis%20within%20low%20ADC%20signal%20regions.%22%2C%22date%22%3A%222025-05%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1002%5C%2Fnbm.70028%22%2C%22ISSN%22%3A%221099-1492%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22UP3H3ICX%22%2C%22P66W67T8%22%2C%226KPLZTET%22%2C%22XTA6KS7L%22%5D%2C%22dateModified%22%3A%222025-11-19T13%3A59%3A13Z%22%7D%7D%2C%7B%22key%22%3A%22JITMD4XG%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Demortiere%20et%20al.%22%2C%22parsedDate%22%3A%222025-05%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BDemortiere%2C%20S.%2C%20Stolowy%2C%20N.%2C%20Perriguey%2C%20M.%2C%20Boutiere%2C%20C.%2C%20Rico%2C%20A.%2C%20Hilezian%2C%20F.%2C%20Ndjomo-Ndjomo%2C%20B.-R.%2C%20Durozard%2C%20P.%2C%20Stellmann%2C%20J.-P.%2C%20Marignier%2C%20R.%2C%20Boucraut%2C%20J.%2C%20Pelletier%2C%20J.%2C%20Maarouf%2C%20A.%20and%20Audoin%2C%20B.%20%282025%29%20%26%23x201C%3BDiagnostic%20Utility%20of%20Kappa%20Free%20Light%20Chain%20Index%20in%20Adults%20With%20Inaugural%20Optic%20Neuritis%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BNeurology%28R%29%20Neuroimmunology%20%26amp%3B%20Neuroinflammation%26lt%3B%5C%2Fi%26gt%3B%2C%2012%283%29%2C%20p.%20e200386.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1212%5C%2FNXI.0000000000200386%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1212%5C%2FNXI.0000000000200386%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Diagnostic%20Utility%20of%20Kappa%20Free%20Light%20Chain%20Index%20in%20Adults%20With%20Inaugural%20Optic%20Neuritis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sarah%22%2C%22lastName%22%3A%22Demortiere%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Natacha%22%2C%22lastName%22%3A%22Stolowy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marine%22%2C%22lastName%22%3A%22Perriguey%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Clemence%22%2C%22lastName%22%3A%22Boutiere%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Audrey%22%2C%22lastName%22%3A%22Rico%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Frederic%22%2C%22lastName%22%3A%22Hilezian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Blaise-Roger%22%2C%22lastName%22%3A%22Ndjomo-Ndjomo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pierre%22%2C%22lastName%22%3A%22Durozard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jan-Patrick%22%2C%22lastName%22%3A%22Stellmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Romain%22%2C%22lastName%22%3A%22Marignier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jos%5Cu00e9%22%2C%22lastName%22%3A%22Boucraut%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean%22%2C%22lastName%22%3A%22Pelletier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Adil%22%2C%22lastName%22%3A%22Maarouf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bertrand%22%2C%22lastName%22%3A%22Audoin%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%20AND%20OBJECTIVES%3A%20A%20simple%2C%20quick%2C%20and%20reproducible%20procedure%20for%20distinguishing%20multiple%20sclerosis%20%28MS%29%2C%20myelin%20oligodendrocyte%20glycoprotein%20antibody-associated%20disease%20%28MOGAD%29%2C%20and%20neuromyelitis%20optica%20spectrum%20disorder%20%28NMOSD%29%20at%20inaugural%20optic%20neuritis%20%28ION%29%20could%20be%20highly%20valuable%20in%20guiding%20early%20management.%5CnMETHODS%3A%20We%20included%20all%20adults%20admitted%20to%20the%20MS%20center%20of%20Marseille%20for%20ION%20between%20March%202016%20and%20April%202024%2C%20with%20CSF%20analysis%20including%20the%20kappa%20free%20light%20chain%20%28K-FLC%29%20index.%20Receiver%20operating%20characteristic%20curves%20were%20used%20to%20measure%20the%20diagnostic%20ability%20of%20the%20K-FLC%20index.%5CnRESULTS%3A%20Two%20hundred%20twenty-seven%20adults%20were%20admitted%20for%20ION%3B%20210%20%2893%25%29%20had%20a%20K-FLC%20index%20measurement.%20MS%20was%20diagnosed%20in%2084%20%2840%25%29%3B%20clinically%20isolated%20syndrome%20suggestive%20of%20MS%20in%2077%20%2836.5%25%29%2C%20including%2020%20with%20future%20conversion%20to%20MS%20%28CISwc%29%3B%20MOGAD%20in%2026%20%2812.5%25%29%3B%20NMOSD%20in%2013%20%286%25%29%3B%20and%20other%20inflammatory%20disorders%20in%2010%20%285%25%29.%20A%20K-FLC%20index%20%5Cu22656.7%20differentiated%20MS%5C%2FCISwc%20from%20other%20diagnoses%20with%20specificity%2086%25%20and%20sensitivity%2095%25%20%28area%20under%20the%20curve%20%5BAUC%5D%200.94%29.%20A%20K-FLC%20index%20%26lt%3B4.9%20differentiated%20MOGAD%20from%20other%20diagnoses%20with%20specificity%2063%25%20and%20sensitivity%2092%25%20%28AUC%200.78%29%20and%20MOGAD%20from%20MS%5C%2FCISwc%20with%20specificity%2096%25%20and%20sensitivity%2092%25%20%28AUC%200.97%29.%20Among%20all%20patients%2C%2093%20%2844%25%29%20had%20a%20K-FLC%20index%20%26lt%3B4.9%3A%2024%20of%20these%20%2826%25%29%20had%20MOGAD%20and%205%20%285.5%25%29%20MS%5C%2FCISwc.%20Among%20the%20remaining%20patients%20with%20a%20K-FLC%20index%20%5Cu22654.9%20%28n%20%3D%20117%29%2C%202%20%281.7%25%29%20had%20MOGAD%20%28K-FLC%20index%20of%207.9%20and%2016.2%29%20and%2099%20%2885%25%29%20MS%5C%2FCISwc.%20Among%20patients%20with%20normal%20MRI%20%28n%20%3D%2096%29%2C%2073%20%2876%25%29%20had%20a%20K-FLC%20index%20%26lt%3B4.9%3A%2022%20of%20these%20%2830%25%29%20had%20MOGAD%2C%20and%20none%20showed%20conversion%20to%20MS.%20Among%20the%20remaining%20patients%20with%20a%20K-FLC%20index%20%5Cu22654.9%20%28n%20%3D%2023%29%2C%202%20%288.5%25%29%20had%20MOGAD%20and%207%20%2830.5%25%29%20showed%20conversion%20to%20MS.%20The%20K-FLC%20index%20did%20not%20differentiate%20NMOSD%20from%20other%20diagnoses%20and%20only%20moderately%20differentiated%20NMO%20from%20MS%5C%2FCISwc%20%28AUC%200.80%29.%5CnDISCUSSION%3A%20The%20K-FLC%20index%20is%20an%20accessible%20biomarker%20to%20guide%20early%20diagnosis%20in%20patients%20with%20ION.%20The%20probability%20of%20MOGAD%20in%20patients%20with%20ION%20and%20a%20K-FLC%20index%20%5Cu22654.9%20is%20low%20even%20in%20case%20of%20normal%20brain%5C%2Fspinal%20cord%20MRI.%5CnCLASSIFICATION%20OF%20EVIDENCE%3A%20This%20study%20provides%20Class%20II%20evidence%20that%20for%20patients%20with%20ION%2C%20the%20K-FLC%20index%20can%20distinguish%20between%20MS%5C%2FCISwc%20and%20MOGAD.%22%2C%22date%22%3A%222025-05%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1212%5C%2FNXI.0000000000200386%22%2C%22ISSN%22%3A%222332-7812%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22KJQH9V8M%22%2C%22B4EWFM7E%22%2C%226KPLZTET%22%2C%229L2KHJ5X%22%5D%2C%22dateModified%22%3A%222025-11-19T13%3A59%3A07Z%22%7D%7D%2C%7B%22key%22%3A%227MW6YQ6K%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Pennec%20et%20al.%22%2C%22parsedDate%22%3A%222025-04-30%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BPennec%2C%20V.L.%2C%20Douane%2C%20F.%2C%20Brun%2C%20J.L.%2C%20Thouveny%2C%20F.%2C%20Martinelli%2C%20T.%2C%20Bravetti%2C%20M.%2C%20Mastier%2C%20C.%2C%20Le%20Bras%2C%20Y.%2C%20Rogopoulos%2C%20A.%2C%20Barral%2C%20P.A.%2C%20Marret%2C%20H.%2C%20Chabrot%2C%20P.%2C%20Jacquier%2C%20A.%2C%20Senechal%2C%20Q.%2C%20Doppelt%2C%20G.%20and%20Frandon%2C%20J.%20%282025%29%20%26%23x201C%3BEndovascular%20management%20of%20pelvic%20congestion%20syndrome%3A%20An%20expert%20consensus%20statement%20from%20the%20French%20Society%20of%20Cardiovascular%20Imaging%20%28SFICV%29%2C%20Interventional%20Radiology%20Federation%20%28FRI%29%2C%20College%20of%20French%20Radiology%20Teachers%20%28CERF%29%2C%20and%20French%20Society%20of%20Women%26%23x2019%3Bs%20Imaging%20%28SIFEM%29%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BDiagnostic%20and%20Interventional%20Imaging%26lt%3B%5C%2Fi%26gt%3B%2C%20pp.%20S2211-5684%2825%2900075%26%23x2013%3B0.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.diii.2025.04.004%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.diii.2025.04.004%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Endovascular%20management%20of%20pelvic%20congestion%20syndrome%3A%20An%20expert%20consensus%20statement%20from%20the%20French%20Society%20of%20Cardiovascular%20Imaging%20%28SFICV%29%2C%20Interventional%20Radiology%20Federation%20%28FRI%29%2C%20College%20of%20French%20Radiology%20Teachers%20%28CERF%29%2C%20and%20French%20Society%20of%20Women%27s%20Imaging%20%28SIFEM%29%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%20Le%22%2C%22lastName%22%3A%22Pennec%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fr%5Cu00e9d%5Cu00e9ric%22%2C%22lastName%22%3A%22Douane%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean%20Luc%22%2C%22lastName%22%3A%22Brun%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Francine%22%2C%22lastName%22%3A%22Thouveny%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Martinelli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marine%22%2C%22lastName%22%3A%22Bravetti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Charles%22%2C%22lastName%22%3A%22Mastier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yan%22%2C%22lastName%22%3A%22Le%20Bras%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andr%5Cu00e9%22%2C%22lastName%22%3A%22Rogopoulos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pierre%20Antoine%22%2C%22lastName%22%3A%22Barral%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Henri%22%2C%22lastName%22%3A%22Marret%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pascal%22%2C%22lastName%22%3A%22Chabrot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexis%22%2C%22lastName%22%3A%22Jacquier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Quentin%22%2C%22lastName%22%3A%22Senechal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gary%22%2C%22lastName%22%3A%22Doppelt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julien%22%2C%22lastName%22%3A%22Frandon%22%7D%5D%2C%22abstractNote%22%3A%22PURPOSE%3A%20Pelvic%20congestion%20syndrome%20%28PCS%29%20is%20a%20major%20cause%20of%20chronic%20pelvic%20pain%20in%20women%20of%20reproductive%20age.%20It%20is%20often%20associated%20with%20pelvic%20venous%20insufficiency%20and%20venous%20dilatation%20of%20the%20ovarian%20and%20uterine%20veins%2C%20resulting%20in%20a%20variety%20of%20symptoms%20exacerbated%20by%20venous%20hypertension.%20Despite%20its%20prevalence%2C%20PCS%20lacks%20standardized%20diagnostic%20and%20management%20protocols%2C%20making%20effective%20treatment%20challenging.%20The%20purpose%20of%20this%20expert%20consensus%20statement%20was%20to%20summarize%20the%20opinions%20of%20French%20radiologists%20and%20gynecologists%20regarding%20the%20diagnosis%2C%20imaging%2C%20treatment%2C%20and%20management%20of%20PCS.%5CnMATERIALS%20AND%20METHODS%3A%20A%20working%20group%20of%2014%20expert%20radiologists%20and%20gynecologists%20from%20various%20French%20medical%20centers%20used%20a%20Delphi%20panel%20approach%20with%20several%20rounds%20of%20remote%20and%20face-to-face%20meetings%20to%20formulate%20and%20refine%20expert%20opinions%20based%20on%20the%20current%20literature%20and%20clinical%20expertise.%20These%20opinions%20were%20categorized%20according%20to%20diagnostic%20criteria%2C%20imaging%20techniques%2C%20therapeutic%20options%2C%20and%20follow-up%20protocols.%5CnRESULTS%3A%20The%20group%20formulated%2072%20initial%20opinions%2C%20and%2065%20were%20retained%20after%20rigorous%20evaluation%20for%20consensus.%20Key%20diagnostic%20tools%20include%20Doppler%20ultrasound%20for%20detection%20of%20venous%20reflux%20and%20magnetic%20resonance%20imaging%20for%20detailed%20assessment%20of%20venous%20anatomy.%20Endovascular%20embolization%20was%20highlighted%20as%20the%20primary%20treatment%20approach%20and%20recommended%20after%20thorough%20imaging%20evaluation.%20Noninvasive%20treatments%20and%20multidisciplinary%20care%20were%20also%20emphasized%20for%20comprehensive%20management.%20The%20expert%20opinion%20also%20included%20post-treatment%20follow-up%20to%20assess%20quality%20of%20life%20and%20symptom%20resolution.%5CnCONCLUSION%3A%20This%20structured%20consensus%20approach%20helped%20develop%20standardized%20expert%20opinions%20on%20management%20of%2C%20providing%20clear%20guidelines%20for%20diagnosis%2C%20treatment%2C%20and%20follow-up.%20These%20guidelines%20should%20improve%20clinical%20practice%20and%20patient%20care%20in%20the%20management%20of%20PCS.%22%2C%22date%22%3A%222025-04-30%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.diii.2025.04.004%22%2C%22ISSN%22%3A%222211-5684%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22KFZ6H27M%22%5D%2C%22dateModified%22%3A%222025-11-19T13%3A59%3A17Z%22%7D%7D%2C%7B%22key%22%3A%22NW8ZZ25N%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Dollomaja%20et%20al.%22%2C%22parsedDate%22%3A%222025-04-11%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BDollomaja%2C%20B.%2C%20Wang%2C%20H.E.%2C%20Guye%2C%20M.%2C%20Makhalova%2C%20J.%2C%20Bartolomei%2C%20F.%20and%20Jirsa%2C%20V.K.%20%282025%29%20%26%23x201C%3BVirtual%20epilepsy%20patient%20cohort%3A%20Generation%20and%20evaluation%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BPLoS%20computational%20biology%26lt%3B%5C%2Fi%26gt%3B%2C%2021%284%29%2C%20p.%20e1012911.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pcbi.1012911%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pcbi.1012911%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Virtual%20epilepsy%20patient%20cohort%3A%20Generation%20and%20evaluation%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Borana%22%2C%22lastName%22%3A%22Dollomaja%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Huifang%20E.%22%2C%22lastName%22%3A%22Wang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maxime%22%2C%22lastName%22%3A%22Guye%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Makhalova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabrice%22%2C%22lastName%22%3A%22Bartolomei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Viktor%20K.%22%2C%22lastName%22%3A%22Jirsa%22%7D%5D%2C%22abstractNote%22%3A%22Epilepsy%20is%20a%20prevalent%20brain%20disorder%2C%20characterized%20by%20sudden%2C%20abnormal%20brain%20activity%2C%20making%20it%20difficult%20to%20live%20with.%20One-third%20of%20people%20with%20epilepsy%20do%20not%20respond%20to%20anti-epileptic%20drugs.%20Drug-resistant%20epilepsy%20is%20treated%20with%20brain%20surgery.%20Successful%20surgical%20treatment%20relies%20on%20identifying%20brain%20regions%20responsible%20for%20seizure%20onset%2C%20known%20as%20epileptogenic%20zones%20%28EZ%29.%20Despite%20various%20methods%20for%20EZ%20estimation%2C%20evaluating%20their%20efficacy%20remains%20challenging%20due%20to%20a%20lack%20of%20ground%20truth%20for%20empirical%20data.%20To%20address%20this%2C%20we%20generated%20and%20evaluated%20a%20cohort%20of%2030%20virtual%20epilepsy%20patients%2C%20using%20patient-specific%20anatomical%20and%20functional%20data%20from%2030%20real%20drug-resistant%20epilepsy%20patients.%20This%20personalized%20modeling%2C%20based%20on%20the%20patient%26%23039%3Bs%20brain%20data%2C%20is%20called%20a%20virtual%20brain%20twin.%20For%20each%20virtual%20patient%2C%20we%20provided%20data%20that%20included%20anatomically%20parcellated%20brain%20regions%2C%20structural%20connectivity%2C%20reconstructed%20intracranial%20electrodes%2C%20simulated%20brain%20activity%20at%20both%20the%20brain%20region%20and%20electrode%20levels%2C%20and%20key%20parameters%20of%20the%20virtual%20brain%20twin.%20These%20key%20parameters%2C%20which%20include%20the%20EZ%20hypothesis%2C%20serve%20as%20the%20ground-truth%20for%20simulated%20brain%20activity.%20For%20each%20virtual%20brain%20twin%2C%20we%20generated%20synthetic%20spontaneous%20seizures%2C%20stimulation-induced%20seizures%20and%20interictal%20activity.%20We%20systematically%20evaluated%20these%20simulated%20brain%20signals%20by%20quantitatively%20comparing%20them%20against%20their%20corresponding%20empirical%20intracranial%20recordings.%20Simulated%20signals%20based%20on%20patient-specific%20EZ%20captured%20spatio-temporal%20seizure%20generation%20and%20propagation.%20Through%20in-silico%20exploration%20of%20stimulation%20parameters%2C%20we%20also%20demonstrated%20the%20role%20of%20patient-specific%20stimulation%20location%20and%20amplitude%20in%20reproducing%20empirically%20stimulated%20seizures.%20The%20virtual%20epileptic%20cohort%20is%20openly%20available%2C%20and%20can%20be%20directly%20used%20to%20systematically%20evaluate%20methods%20for%20the%20estimation%20of%20EZ%20or%20source%20localization%20using%20ground%20truth%20EZ%20parameters%20and%20source%20signals.%22%2C%22date%22%3A%222025-04-11%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1371%5C%2Fjournal.pcbi.1012911%22%2C%22ISSN%22%3A%221553-7358%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22XTA6KS7L%22%2C%229RMECNPE%22%5D%2C%22dateModified%22%3A%222025-11-19T13%3A59%3A15Z%22%7D%7D%2C%7B%22key%22%3A%22WXTRWDEL%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Cotinat%20et%20al.%22%2C%22parsedDate%22%3A%222025-04-09%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BCotinat%2C%20M.%2C%20Robinet%2C%20E.%2C%20Messaoudi%2C%20N.%2C%20Suissa%2C%20L.%2C%20Doche%2C%20E.%2C%20Guye%2C%20M.%2C%20Bensoussan%2C%20L.%2C%20Zaaraoui%2C%20W.%20and%20Ranjeva%2C%20J.-P.%20%282025%29%20%26%23x201C%3BAdded%20Value%20of%20Sodium%20MR%20Imaging%20and%20Proton%20MR%20Spectroscopy%20to%20Conventional%20MR%20Imaging%20for%20a%20Better%20Characterization%20of%20the%20Ischemic%20Stroke%3A%20A%20Narrative%20Review%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BMagnetic%20resonance%20in%20medical%20sciences%3A%20MRMS%3A%20an%20official%20journal%20of%20Japan%20Society%20of%20Magnetic%20Resonance%20in%20Medicine%26lt%3B%5C%2Fi%26gt%3B%20%5BPreprint%5D.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.2463%5C%2Fmrms.rev.2025-0002%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.2463%5C%2Fmrms.rev.2025-0002%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Added%20Value%20of%20Sodium%20MR%20Imaging%20and%20Proton%20MR%20Spectroscopy%20to%20Conventional%20MR%20Imaging%20for%20a%20Better%20Characterization%20of%20the%20Ischemic%20Stroke%3A%20A%20Narrative%20Review%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ma%5Cu00ebva%22%2C%22lastName%22%3A%22Cotinat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Robinet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22No%5Cu00eblle%22%2C%22lastName%22%3A%22Messaoudi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laurent%22%2C%22lastName%22%3A%22Suissa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emilie%22%2C%22lastName%22%3A%22Doche%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maxime%22%2C%22lastName%22%3A%22Guye%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laurent%22%2C%22lastName%22%3A%22Bensoussan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wafaa%22%2C%22lastName%22%3A%22Zaaraoui%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Philippe%22%2C%22lastName%22%3A%22Ranjeva%22%7D%5D%2C%22abstractNote%22%3A%22Stroke%20is%20a%20major%20cause%20of%20disability%20and%20death%20in%20adults%20worldwide.%20In%20clinical%20setting%2C%20time%20efficient%20MRI%20protocols%20including%20diffusion%20weighted%20images%2C%20fluid%20attenuated%20inversion%20recovery%2C%20fast%20T2%2A-weighted%20images%20and%20MR%20angiography%20aim%20to%20establish%20ischemic%20stroke%20diagnosis%2C%20visualize%20vessel%20occlusion%20and%20determine%20the%20extent%20of%20ischemia%20damage%20distinguishing%20between%20the%20salvageable%20ischemic%20penumbra%20and%20the%20infarct%20core.%20Thus%2C%20MRI%20plays%20a%20pivotal%20role%20in%20diagnosis%2C%20treatment%20decision-making%2C%20and%20prognostic%20assessment%2C%20although%20prediction%20based%20on%20these%20elements%20remains%20limited%20and%20can%20be%20improved.%20We%20reviewed%20the%20added-values%20of%20alternative%20MRI%20methods%20such%20as%20sodium%2823Na%29%20MRI%20and%201H%20MR%20spectroscopic%20imaging%20that%20open%20new%20temporal%20and%20pathophysiological%20windows%20on%20ionic%20dys-homeostasis%20and%20metabolism%20alteration%20in%20the%20context%20of%20ischemic%20stroke%20and%20reperfusion.%20Insights%20on%20the%20timeline%20of%20the%20cellular%20events%20accessible%20using%20these%20alternative%20methods%20and%20perspectives%20to%20improve%20clinical%20outcome%20prediction%20of%20ischemic%20stroke%20patients%20are%20discussed.%22%2C%22date%22%3A%222025-04-09%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.2463%5C%2Fmrms.rev.2025-0002%22%2C%22ISSN%22%3A%221880-2206%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22UP3H3ICX%22%2C%22HVJZKIZG%22%2C%22P66W67T8%22%5D%2C%22dateModified%22%3A%222025-11-19T13%3A59%3A19Z%22%7D%7D%2C%7B%22key%22%3A%22NCYFCF6W%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Hong%20et%20al.%22%2C%22parsedDate%22%3A%222025-04-05%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BHong%2C%20J.%2C%20Gaubert%2C%20M.%2C%20Lefort%2C%20M.%2C%20Ferr%26%23xE9%3B%2C%20J.C.%2C%20Le%20Page%2C%20E.%2C%20Michel%2C%20L.%2C%20Labauge%2C%20P.%2C%20Pelletier%2C%20J.%2C%20de%20Seze%2C%20J.%2C%20Durand-Dubief%2C%20F.%2C%20Cotton%2C%20F.%2C%20Edan%2C%20G.%2C%20Bannier%2C%20E.%2C%20Comb%26%23xE8%3Bs%2C%20B.%20and%20Kerbrat%2C%20A.%20%282025%29%20%26%23x201C%3BLimited%20added%20value%20of%20systematic%20spinal%20cord%20MRI%20vs%20brain%20MRI%20alone%20to%20classify%20patients%20with%20MS%20as%20active%20or%20inactive%20during%20follow-up%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BJournal%20of%20Neurology%26lt%3B%5C%2Fi%26gt%3B%2C%20272%284%29%2C%20p.%20316.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00415-025-13068-2%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00415-025-13068-2%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Limited%20added%20value%20of%20systematic%20spinal%20cord%20MRI%20vs%20brain%20MRI%20alone%20to%20classify%20patients%20with%20MS%20as%20active%20or%20inactive%20during%20follow-up%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00e9r%5Cu00e9my%22%2C%22lastName%22%3A%22Hong%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Malo%22%2C%22lastName%22%3A%22Gaubert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mathilde%22%2C%22lastName%22%3A%22Lefort%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean%20Christophe%22%2C%22lastName%22%3A%22Ferr%5Cu00e9%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Le%20Page%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laure%22%2C%22lastName%22%3A%22Michel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pierre%22%2C%22lastName%22%3A%22Labauge%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean%22%2C%22lastName%22%3A%22Pelletier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00e9r%5Cu00f4me%22%2C%22lastName%22%3A%22de%20Seze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fran%5Cu00e7oise%22%2C%22lastName%22%3A%22Durand-Dubief%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fran%5Cu00e7ois%22%2C%22lastName%22%3A%22Cotton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gilles%22%2C%22lastName%22%3A%22Edan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elise%22%2C%22lastName%22%3A%22Bannier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benoit%22%2C%22lastName%22%3A%22Comb%5Cu00e8s%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne%22%2C%22lastName%22%3A%22Kerbrat%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20The%20utility%20of%20systematic%20spinal%20cord%20%28SC%29%20MRI%20for%20monitoring%20disease%20activity%20after%20a%20multiple%20sclerosis%20%28MS%29%20diagnosis%20remains%20a%20topic%20of%20debate.%5CnOBJECTIVES%3A%20To%20evaluate%20the%20frequency%20of%20disease%20activity%20when%20considering%20brain%20MRI%20alone%20versus%20both%20brain%20and%20SC%20MRI%20and%20to%20identify%20factors%20associated%20with%20the%20occurrence%20of%20new%20SC%20lesions.%5CnMETHODS%3A%20We%20conducted%20a%20retrospective%20analysis%20of%20clinical%20and%20imaging%20data%20prospectively%20collected%20over%205%5Cu00a0years%20as%20part%20of%20the%20EMISEP%20cohort%20study.%20A%20total%20of%20221%20intervals%20%28with%20both%20brain%20and%20spinal%20cord%20MRI%20scans%20available%20at%202%20consecutive%20time-points%29%20from%2068%20patients%20were%20analysed.%20For%20each%20interval%2C%20brain%20%283D%20Fluid-Attenuated%20Inversion%20Recovery%20%28FLAIR%2C%20axial%20T2%20and%20axial%20PD%29%20and%20SC%20MRI%20%28sagittal%20T2%20and%20phase-sensitive%20inversion%20recovery%2C%20axial%20T2%2Aw%20and%203D%20T1%29%20were%20reviewed%20to%20detect%20new%20lesions.%20Each%20interval%20was%20classified%20as%20symptomatic%20%28with%20relapse%29%20or%20asymptomatic.%20The%20baseline%20brain%20and%20SC%20lesion%20numbers%20were%20computed.%5CnRESULTS%3A%20SC%20MRI%20activity%20without%20clinical%20relapse%20and%5C%2For%20brain%20MRI%20activity%20was%20rare%20%284%20out%20of%20221%20intervals%2C%202%25%29.%20The%20occurrence%20of%20a%20new%20SC%20lesion%20was%20associated%20with%20the%20number%20of%20brain%20lesions%20at%20baseline%20%28OR%20%3D%5Cu20091.002%20%5B1.000%3B%201.0004%5D%2C%20p%5Cu2009%3D%200.015%29%20and%20the%20occurrence%20of%20a%20new%20brain%20lesion%20during%20the%20interval%20%28OR%20%3D%5Cu20091.170%20%5B1.041%3B%201.314%5D%2C%20p%5Cu2009%3D%200.009%29%2C%20but%20not%20with%20the%20baseline%20SC%20lesion%20number%20%28p%5Cu2009%3D%200.6%29.%5CnCONCLUSION%3A%20These%20findings%20support%20the%20current%20guidelines%20recommending%20routine%20disease%20monitoring%20with%20brain%20MRI%20alone%2C%20even%20in%20patients%20with%20a%20high%20SC%20lesion%20load.%22%2C%22date%22%3A%222025-04-05%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1007%5C%2Fs00415-025-13068-2%22%2C%22ISSN%22%3A%221432-1459%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22B4EWFM7E%22%5D%2C%22dateModified%22%3A%222025-11-19T13%3A59%3A16Z%22%7D%7D%2C%7B%22key%22%3A%22T6U3CK9C%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Lod%5Cu00e9%20et%20al.%22%2C%22parsedDate%22%3A%222025-04-04%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BLod%26%23xE9%3B%2C%20B.%2C%20Hussein%2C%20B.R.%2C%20Meur%26%23xE9%3Be%2C%20C.%2C%20Walsh%2C%20R.%2C%20Gaubert%2C%20M.%2C%20Lassalle%2C%20N.%2C%20Courbon%2C%20G.%2C%20Martin%2C%20A.%2C%20Le%20Bars%2C%20J.%2C%20Durand-Dubief%2C%20F.%2C%20Bourre%2C%20B.%2C%20Maarouf%2C%20A.%2C%20Outteryck%2C%20O.%2C%20Mehier%2C%20C.%2C%20Poulin%2C%20A.%2C%20Cathelineau%2C%20C.%2C%20Hong%2C%20J.%2C%20Criton%2C%20G.%2C%20Motillon-Alonso%2C%20S.%2C%20Lecler%2C%20A.%2C%20Charbonneau%2C%20F.%2C%20Duron%2C%20L.%2C%20Bani-Sadr%2C%20A.%2C%20Delpierre%2C%20C.%2C%20Ferr%26%23xE9%3B%2C%20J.-C.%2C%20Edan%2C%20G.%2C%20Cotton%2C%20F.%2C%20Casey%2C%20R.%2C%20Galassi%2C%20F.%2C%20Comb%26%23xE8%3Bs%2C%20B.%20and%20Kerbrat%2C%20A.%20%282025%29%20%26%23x201C%3BEvaluation%20of%20a%20deep%20learning%20segmentation%20tool%20to%20help%20detect%20spinal%20cord%20lesions%20from%20combined%20T2%20and%20STIR%20acquisitions%20in%20people%20with%20multiple%20sclerosis%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BEuropean%20Radiology%26lt%3B%5C%2Fi%26gt%3B%20%5BPreprint%5D.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00330-025-11541-0%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00330-025-11541-0%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Evaluation%20of%20a%20deep%20learning%20segmentation%20tool%20to%20help%20detect%20spinal%20cord%20lesions%20from%20combined%20T2%20and%20STIR%20acquisitions%20in%20people%20with%20multiple%20sclerosis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Baptiste%22%2C%22lastName%22%3A%22Lod%5Cu00e9%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Burhan%20Rashid%22%2C%22lastName%22%3A%22Hussein%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C%5Cu00e9dric%22%2C%22lastName%22%3A%22Meur%5Cu00e9e%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ricky%22%2C%22lastName%22%3A%22Walsh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Malo%22%2C%22lastName%22%3A%22Gaubert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Lassalle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guilhem%22%2C%22lastName%22%3A%22Courbon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Agathe%22%2C%22lastName%22%3A%22Martin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jeanne%22%2C%22lastName%22%3A%22Le%20Bars%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fran%5Cu00e7oise%22%2C%22lastName%22%3A%22Durand-Dubief%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bertrand%22%2C%22lastName%22%3A%22Bourre%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Adil%22%2C%22lastName%22%3A%22Maarouf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Olivier%22%2C%22lastName%22%3A%22Outteryck%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cl%5Cu00e9ment%22%2C%22lastName%22%3A%22Mehier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandre%22%2C%22lastName%22%3A%22Poulin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Camille%22%2C%22lastName%22%3A%22Cathelineau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jeremy%22%2C%22lastName%22%3A%22Hong%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guillaume%22%2C%22lastName%22%3A%22Criton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sophie%22%2C%22lastName%22%3A%22Motillon-Alonso%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Augustin%22%2C%22lastName%22%3A%22Lecler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fr%5Cu00e9d%5Cu00e9rique%22%2C%22lastName%22%3A%22Charbonneau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lo%5Cu00efc%22%2C%22lastName%22%3A%22Duron%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandre%22%2C%22lastName%22%3A%22Bani-Sadr%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C%5Cu00e9line%22%2C%22lastName%22%3A%22Delpierre%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Christophe%22%2C%22lastName%22%3A%22Ferr%5Cu00e9%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gilles%22%2C%22lastName%22%3A%22Edan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fran%5Cu00e7ois%22%2C%22lastName%22%3A%22Cotton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Romain%22%2C%22lastName%22%3A%22Casey%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Francesca%22%2C%22lastName%22%3A%22Galassi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benoit%22%2C%22lastName%22%3A%22Comb%5Cu00e8s%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne%22%2C%22lastName%22%3A%22Kerbrat%22%7D%5D%2C%22abstractNote%22%3A%22OBJECTIVE%3A%20To%20develop%20a%20deep%20learning%20%28DL%29%20model%20for%20the%20detection%20of%20spinal%20cord%20%28SC%29%20multiple%20sclerosis%20%28MS%29%20lesions%20from%20both%20sagittal%20T2%20and%20short%20tau%20inversion%20recovery%20%28STIR%29%20sequences%20and%20to%20investigate%20whether%20such%20a%20model%20could%20improve%20the%20performance%20of%20clinicians%20in%20detecting%20SC%20lesions.%5CnMATERIALS%20AND%20METHODS%3A%20A%20DL%20tool%20was%20developed%20based%20on%20SC%20sagittal%20T2%20and%20STIR%20acquisitions%20from%20the%20imaging%20database%20of%20the%20French%20MS%20registry%20%28OFSEP%29%2C%20including%20retrospective%20data%20from%2040%20different%20scanners.%20A%20multi-reader%20study%20based%20on%20retrospective%20data%20was%20performed%20between%20December%202023%20and%20June%202024%20to%20compare%20the%20performance%20of%2020%20clinicians%20in%20interpreting%20upper%20and%20lower%20SC%20acquisitions%20with%20and%20without%20the%20use%20of%20the%20tool.%20A%20ground%20truth%20was%20established%20by%20three%20experts.%20Sensitivity%2C%20precision%2C%20and%20inter-reader%20variability%20were%20evaluated.%5CnRESULTS%3A%20We%20included%2050%20patients%20%2839%20females%2C%20median%20age%3A%2041%20years%20%5Brange%3A%2015-67%5D%29%20with%20SC%20MRI%20acquired%20between%20February%202017%20and%20December%202022.%20When%20reading%20with%20the%20tool%2C%20the%20clinicians%26%23039%3B%20mean%20sensitivity%20to%20detect%20SC%20lesions%20improved%20%28from%2074.3%25%20%5B95%25%20CI%5Cu2009%3D%5Cu200967.8-80.6%25%5D%20to%2079.2%25%20%5B95%25%20CI%3A%2073.5-85.0%25%5D%3B%20p%5Cu2009%26lt%3B%5Cu20090.0001%29%2C%20with%20no%20evidence%20of%20difference%20in%20the%20mean%20precision%3A%20%2869.0%25%20%5B95%25%20CI%3A%2062.8-75.2%25%5D%20vs%2070.1%25%20%5B95%25%20CI%3A%2064.3-75.9%25%5D%3B%20p%5Cu2009%3D%5Cu20090.08%29.%20Inter-reader%20variability%20in%20lesion%20detection%20was%20slightly%20improved%20with%20the%20tool%20%28Light%26%23039%3Bs%20kappa%5Cu2009%3D%200.55%20vs%200.60%29%2C%20but%20without%20statistical%20difference%20%28p%5Cu2009%3D%5Cu20090.056%29.%5CnCONCLUSION%3A%20The%20use%20of%20an%20automatic%20tool%20can%20help%20clinicians%20detect%20SC%20lesions%20in%20pwMS%20by%20increasing%20their%20sensitivity.%5CnKEY%20POINTS%3A%20Question%20No%20tool%20to%20help%20detect%20MS%20SC%20lesions%20is%20used%20in%20clinical%20practice%20despite%20their%20frequency%20and%20prognostic%20value.%20Findings%20This%20DL-based%20tool%20led%20to%20improvement%20in%20clinicians%26%23039%3B%20sensitivity%20in%20detecting%20SC%20lesions%20from%20both%20sagittal%20T2%20and%20STIR%20sequences%2C%20without%20decreasing%20precision.%20Clinical%20relevance%20Our%20study%20indicated%20the%20potential%20of%20a%20DL-based%20tool%20to%20assist%20clinicians%20in%20the%20challenging%20task%20of%20detecting%20SC%20lesions%20in%20people%20with%20MS%20on%20a%20combination%20of%20sequences%20commonly%20acquired%20in%20clinical%20practice.%22%2C%22date%22%3A%222025-04-04%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1007%5C%2Fs00330-025-11541-0%22%2C%22ISSN%22%3A%221432-1084%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22KJQH9V8M%22%5D%2C%22dateModified%22%3A%222025-11-19T13%3A59%3A14Z%22%7D%7D%2C%7B%22key%22%3A%22T5DYS4X8%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Piazzola%20et%20al.%22%2C%22parsedDate%22%3A%222025-04-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BPiazzola%2C%20C.%2C%20Graillon%2C%20T.%2C%20Girard%2C%20N.%2C%20Dufour%2C%20H.%2C%20Brue%2C%20T.%20and%20Castinetti%2C%20F.%20%282025%29%20%26%23x201C%3BDesmopressin%20is%20a%20safe%20and%20effective%20secretagogue%20to%20replace%20corticotropin-releasing%20hormone%20in%20petrosal%20sinus%20sampling%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BAnnales%20d%26%23x2019%3BEndocrinologie%26lt%3B%5C%2Fi%26gt%3B%2C%2086%282%29%2C%20p.%20101678.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.ando.2024.101678%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.ando.2024.101678%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Desmopressin%20is%20a%20safe%20and%20effective%20secretagogue%20to%20replace%20corticotropin-releasing%20hormone%20in%20petrosal%20sinus%20sampling%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cecilia%22%2C%22lastName%22%3A%22Piazzola%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Graillon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadine%22%2C%22lastName%22%3A%22Girard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Henry%22%2C%22lastName%22%3A%22Dufour%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thierry%22%2C%22lastName%22%3A%22Brue%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Frederic%22%2C%22lastName%22%3A%22Castinetti%22%7D%5D%2C%22abstractNote%22%3A%22Purpose%5CnBilateral%20inferior%20petrosal%20sinus%20sampling%20%28BIPSS%29%20with%20corticotropin-releasing%20hormone%20%28CRH%29%20was%20the%20gold%20standard%20for%20distinguishing%20Cushing%20disease%20%28CD%29%20from%20ectopic%20ACTH%20secretion%20%28EAS%29.%20CRH%2C%20however%2C%20is%20no%20longer%20available.%5CnObjective%5CnTo%20assess%20the%20reliability%20of%20BIPSS%20with%20desmopressin%20to%20differentiate%20CD%20from%20EAS.%5CnMethods%5CnA%20retrospective%20study%20included%20patients%20who%20underwent%20BIPSS%20with%20desmopressin%20for%20ACTH-dependent%20hypercortisolism%2C%20with%20the%20whole%20diagnostic%20procedure%20in%20a%20single%20center.%5CnResults%5CnFifty-eight%20patients%20with%20confirmed%20etiological%20diagnosis%20were%20included%3A%2051%20CD%2C%207%20EAS.%20Forty-three%20CD%20patients%20%2884.3%25%29%20had%20post-stimulation%20ratio%20%5Cu22652%20before%20stimulation%20and%206%20of%20the%20other%208%20%2875%25%29%20had%20a%20ratio%20%5Cu22653.%20All%20EAS%20patients%20were%20correctly%20diagnosed%20before%20and%20after%20stimulation.%20Sensitivity%20was%2084.3%25%20before%20stimulation%20and%2092.2%25%20combining%20pre-%20and%20post-stimulation%20results%3B%20specificity%20reached%20100%25.%20A%20ROC%20curve%20established%20optimal%20thresholds%20at%201.4%20before%20stimulation%20and%201.7%20after.%5CnConclusion%5CnDesmopressin%20is%20a%20good%20substitute%20for%20CRH%2C%20correcting%20diagnosis%20compared%20to%20baseline%20BIPSS%20in%2012%25%20of%20cases.%22%2C%22date%22%3A%222025-04-01%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.ando.2024.101678%22%2C%22ISSN%22%3A%220003-4266%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.sciencedirect.com%5C%2Fscience%5C%2Farticle%5C%2Fpii%5C%2FS0003426624007613%22%2C%22collections%22%3A%5B%22W98NEAUQ%22%5D%2C%22dateModified%22%3A%222025-11-19T13%3A59%3A12Z%22%7D%7D%5D%7D
Agripnidis, T., Ayobi, A., Quenet, S., Chaibi, Y., Avare, C., Jacquier, A., Girard, N., Hak, J.-F., Reyre, A., Brun, G. and El Ahmadi, A.-A. (2025) “Performance of an artificial intelligence tool for multi-step acute stroke imaging: A multicenter diagnostic study,” European Journal of Radiology Open, 15, p. 100678. Available at: https://doi.org/10.1016/j.ejro.2025.100678.
Tikhonenko, D., Rustomji, K., Vilmen, C., Durand, A., Nouari, G., Enoch, S., Bendahan, D., Abdeddaim, R. and Dubois, M. (2025) “Optimal excitation of single mode resonators: demonstration with a 3 T MRI metasolenoid,” Journal of Magnetic Resonance (San Diego, Calif.: 1997), 382, p. 107992. Available at: https://doi.org/10.1016/j.jmr.2025.107992.
Dalmas, F., Foing, C., Darrason, G., Varoquaux, A., Mazodier, K., Muller, R., Foletti, J.-M., Guyot, L., Cauchois, R., Jean, R., Kaplanski, G., Cuny, T. and Jarrot, P.-A. (2025) “Long-term tocilizumab therapy in patients with corticosteroid-resistant active moderate-to-severe thyroid eye disease,” European Journal of Endocrinology, p. lvaf227. Available at: https://doi.org/10.1093/ejendo/lvaf227.
Fournel, J., De Masi, M., Lu, C., Omnes, V., Muselier, B., Ghattas, B., Bouchot, O., Kafi, M., Lalande, A., Gaudry, M., Jacquier, A. and Bartoli, A. (2025) “Deep learning-driven false-lumen volumes predict adverse remodeling better than diameter in patients with residual aortic dissection on CT,” European Radiology [Preprint]. Available at: https://doi.org/10.1007/s00330-025-12116-9.
Gauer, L., Haast, R.A.M., Azilinon, M., El Mendili, M.M., Makhalova, J., Dary, H., Dinkelacker, V., Ridley, B., Ranjeva, J.-P., Zaaraoui, W., Bartolomei, F. and Guye, M. (2025) “Investigating sodium homeostasis of structural brain hubs in focal epilepsy using 7 T MRI,” Brain: A Journal of Neurology, p. awaf409. Available at: https://doi.org/10.1093/brain/awaf409.
Stellmann, J.-P., Maarouf, A., Nicolescu, M., Boutiere, C., Rico, A., Zaaraoui, W., Guye, M., Pelletier, J., Ranjeva, J.-P. and Audoin, B. (2025) “Early structural hub disruption leads to premature functional adaption in multiple sclerosis,” Brain Structure & Function, 230(9), p. 172. Available at: https://doi.org/10.1007/s00429-025-03023-2.
Grass, L., Grimaldi, S. and Damier, P. (2025) “Prodromal Parkinson’s disease,” Revue Neurologique, 181(9), pp. 863–880. Available at: https://doi.org/10.1016/j.neurol.2025.06.012.
Wilson, S., Leray, E., Calocer, F., Rollot, F., Fauvernier, M., Remontet, L., Launay, L., Vukusic, S., Le Page, E., Debouverie, M., Ciron, J., Ruet, A., Seze, J.D., Zephir, H., Moreau, T., Laplaud, D.-A., Lebrun-Frenay, C., Clavelou, P., Labauge, P., Berger, E., Pelletier, J., Heinzlef, O., Thouvenot, E., Camdessanché, J.P., Arnaud, C., Derache, N., Branger, P., Guittet, L., Defer, G. and Dejardin, O. (2025) “Influence of geographical accessibility to specialist and primary care givers on excess mortality of multiple sclerosis patients in France,” BMC neurology, 25(1), p. 441. Available at: https://doi.org/10.1186/s12883-025-04459-z.
Mira, V., Stellman, J.P. and Grimaldi, S. (2025) “Paroxysmal Dystonia: An Etiology Not to Be Missed in an Older Adult Patient,” Movement Disorders Clinical Practice [Preprint]. Available at: https://doi.org/10.1002/mdc3.70407.
Thakolwiboon, S., Redenbaugh, V., Chen, B., Hewitt, S., Shah, S., Lotan, I., Levy, M., Forcadela, M., Huda, S., Pique, J., Marignier, R., Boutiere, C., Audoin, B., Poullin, P., Champsas, D., Choi, D., Danesh-Meyer, H.V., Vasileiou, E., Sotirchos, E.S., Davis, J.B., Henderson, A.D., Wilf-Yarkoni, A., Stiebel-Kalish, H., Maillart, E., Bonelli, L., Arnold, A.C., Boudot De La Motte, M., Deschamps, R., Jitprapaikulsan, J., Moss, H.E., Villarreal Navarro, S.E., Mao-Draayer, Y., Mishra, M., Vorasoot, N., Cacciaguerra, L., Tisavipat, N., Tajfirouz, D.A., Tillema, J.-M., Lopez-Chiriboga, S.A., Palace, J., Hacohen, Y., Pittock, S.J., Flanagan, E.P. and Chen, J.J. (2025) “Outcomes After Acute Plasma Exchange for Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease,” Neurology, 105(6), p. e213903. Available at: https://doi.org/10.1212/WNL.0000000000213903.
Melka, M., Rotard, L., Benstaali, C., Brocard, J., Giannesini, B., Jouve, F., Pelletier, L., Fauré, J., Rendu, J., Jacquemond, V. and Marty, I. (2025) “Limited pre-clinical relevance of the heterozygous RYR1-I4895T/+ mouse model due to its mild phenotype,” Journal of Neuromuscular Diseases, p. 22143602251339354. Available at: https://doi.org/10.1177/22143602251339354.
Feys, O., Makhalova, J., Manners, T., Herrera-García, J.-D., Carron, R. and Bartolomei, F. (2025) “Radiofrequency thermocoagulation for the treatment of refractory focal status epilepticus,” Epileptic Disorders: International Epilepsy Journal with Videotape [Preprint]. Available at: https://doi.org/10.1002/epd2.70091.
Martin, S., Trabelsi, A., Guye, M., Dubois, M., Abdeddaim, R., Bendahan, D. and André, R. (2025) “Optimized reconstruction of undersampled Dixon sequences using new memory-efficient unrolled deep neural networks: HalfVarNet and HalfDIRCN,” Magnetic Resonance in Medicine [Preprint]. Available at: https://doi.org/10.1002/mrm.70070.
Porto, A., Court, A., Barral, P.A., Boucekine, M., Imbert, L., Gariboldi, V., Jacquier, A., Collart, F., Theron, A. and Gaudry, M. (2025) “Evolution of Aortic Root Preservation After Type A Acute Aortic Dissection Repair: Impact of Root-Residual Aortic Dissection,” Journal of Clinical Medicine, 14(17), p. 6274. Available at: https://doi.org/10.3390/jcm14176274.
Gavoille, A., Nourredine, M., Rollot, F., Casey, R., Mathey, G., Kerbrat, A., Ciron, J., De Sèze, J., Stankoff, B., Maillart, E., Ruet, A., Labauge, P., Kwiatkowski, A., Zephir, H., Papeix, C., Defer, G., Lebrun-Frenay, C., Moreau, T., Laplaud, D.-A., Berger, E., Clavelou, P., Thouvenot, E., Heinzlef, O., Pelletier, J., Al Khedr, A., Casez, O., Bourre, B., Wahab, A., Magy, L., Moulin, S., Camdessanché, J.-P., Doghri, I., Sarov, M., Hankiewicz, K., Pottier, C., Dos Santos, A., Manchon, E., Tchikviladze, M., Rabilloud, M., Subtil, F. and Vukusic, S. (2025) “Target trial emulation to replicate randomised clinical trials using registry data in multiple sclerosis,” Journal of Neurology, Neurosurgery, and Psychiatry, p. jnnp-2025-336762. Available at: https://doi.org/10.1136/jnnp-2025-336762.
Russell-Hallinan, A., Karuna, N., Lezoualc’h, F., Matullo, G., Baker, H., Bernard, M., Devaux, Y., Badimon, L., Vilahur, G., Rieusset, J., Derumeaux, G.A. and Watson, C.J. (2025) “Established and Emerging Roles of Epigenetic Regulation in Diabetic Cardiomyopathy,” Diabetes/Metabolism Research and Reviews, 41(6), p. e70081. Available at: https://doi.org/10.1002/dmrr.70081.
Andikoetxea, B.G., Martín-Bastida, A., Vidorreta, M., Rodríguez-Oroz, M.C., Soustelle, L., Troalen, T. and Fernández-Seara, M.A. (2025) “Neuromelanin Contrast Optimization and Improved Visualization of the Substantia Nigra in a 3D Gradient-Echo Sequence With Magnetization Transfer,” NMR in biomedicine, 38(9), p. e70123. Available at: https://doi.org/10.1002/nbm.70123.
Gavoille, A., Leray, E., Marignier, R., Rollot, F., Casey, R., Mathey, G., Michel, L., De Seze, J., Ciron, J., Ruet, A., Maillart, E., Labauge, P., Zephir, H., Laplaud, D.A., Papeix, C., Defer, G., Moreau, T., Berger, E., Dubessy, A.-L., Clavelou, P., Thouvenot, E., Heinzlef, O., Pelletier, J., Al Khedr, A., Casez, O., Bourre, B., Wahab, A., Magy, L., Camdessanche, J.-P., Doghri, I., Moulin, S., Labeyrie, C., Hankiewicz, K., Dos Santos, A., Pottier, C., Manchon, E., Tchikviladze, M., Lebrun-Frenay, C., Vukusic, S. and OFSEP investigators (2025) “Sex-Related Gap in the Use of Disease-Modifying Therapies in Multiple Sclerosis,” Neurology, 105(4), p. e213907. Available at: https://doi.org/10.1212/WNL.0000000000213907.
Bernard, M. (2025) “Assessment of Left Atrial Fibrosis With Cardiac MRI,” Journal of magnetic resonance imaging: JMRI [Preprint]. Available at: https://doi.org/10.1002/jmri.70103.
De Masi, M., Guivier-Curien, C., Gaudry, M., Jacquier, A., Piquet, P. and Deplano, V. (2025) “Geometric Aortic Remodeling and Stent-Graft Migration After TEVAR: Insights from Longitudinal 3D Analysis and Literature Review,” Journal of Personalized Medicine, 15(8), p. 393. Available at: https://doi.org/10.3390/jpm15080393.
Joppin, V., Masson, C., Bendahan, D. and Bege, T. (2025) “A review of ventral hernia biomechanics,” Journal of the Mechanical Behavior of Biomedical Materials, 173, p. 107159. Available at: https://doi.org/10.1016/j.jmbbm.2025.107159.
Bouazizi, K., Yoganathan, T., Kober, F., Autret, G., Marsac, P., Delacroix, C., Soulez, S., Zarai, M., Nguyen, V., Squalli, A., Alayrac, P., Robidel, E., Tavitian, B., Redheuil, A., Hulot, J.-S. and Kachenoura, N. (2025) “Left ventricle strain and T1 mapping evaluation in a mouse model with myocardial infarction,” Scientific Reports, 15(1), p. 29579. Available at: https://doi.org/10.1038/s41598-025-09699-0.
Robin, C., Rollot, F., Lefort, M., Casey, R., Vukusic, S., Mathey, G., Ciron, J., De Seze, J., Stankoff, B., Maillart, E., Ruet, A., Labauge, P.M., Kwiatkowski, A., Zephir, H., Papeix, C., Defer, G., Lebrun-Frenay, C., Moreau, T., Laplaud, D.A., Berger, E., Clavelou, P., Thouvenot, E., Heinzlef, O., Pelletier, J., Casez, O., Bourre, B., Wahab, A., Magy, L., Moulin, S., Camdessanche, J.-P., Doghri, I., Sarov, M., Hankiewicz, K., Pottier, C., Dos Santos, A., Manchon, E., Tchikviladze, M., Nifle, C., Kerbrat, A., Edan, G., Le Page, E., Michel, L. and as the OFSEP Investigators (2025) “Use of Disease-Modifying Therapies in Patients With Late-Onset Multiple Sclerosis,” Neurology, 105(3), p. e213744. Available at: https://doi.org/10.1212/WNL.0000000000213744.
Gavoille, A., Rollot, F., Casey, R., Mathey, G., Le Page, E., Ciron, J., De Sèze, J., Ruet, A., Maillart, E., Labauge, P., Zephir, H., Kwiatkowski, A., Papeix, C., Defer, G., Lebrun-Frenay, C., Moreau, T., Laplaud, D.-A., Berger, E., Dubessy, A.-L., Clavelou, P., Thouvenot, E., Heinzlef, O., Pelletier, J., Al-Khedr, A., Casez, O., Bourre, B., Wahab, A., Magy, L., Moulin, S., Camdessanché, J.-P., Doghri, I., Sarov-Riviere, M., Hankiewicz, K., Pottier, C., Dos Santos, A., Nifle, C., Subtil, F., Vukusic, S. and OFSEP Investigators (2025) “Therapeutic Management During Pregnancy and Relapse Risk in Women With Multiple Sclerosis,” JAMA neurology [Preprint]. Available at: https://doi.org/10.1001/jamaneurol.2025.2550.
Nimje, S., Artières, T., Guye, M. and de Rochefort, L. (2025) “Insights on Scan-Specific Deep-Learning Strategies for Brain MRI Parallel Imaging Reconstruction,” NMR in biomedicine, 38(8), p. e70079. Available at: https://doi.org/10.1002/nbm.70079.
Attia, R., Stolowy, N., Fitoussi, R. and David, T. (2025) “Severe corneal flattening in bilateral cornea plana,” Journal Francais D’ophtalmologie, 48(7), p. 104587. Available at: https://doi.org/10.1016/j.jfo.2025.104587.
Abou Assi, A., Armand, M., Sarté, C., Tafflet, M., Yuan, W.L., Peyre, H., Charles, M.-A., Heude, B. and Bernard, J.Y. (2025) “Patterns of perinatal exposure to PUFAs and child neurodevelopment: evidence from Mendelian randomization using FADS cluster variants,” The American Journal of Clinical Nutrition, 122(1), pp. 235–243. Available at: https://doi.org/10.1016/j.ajcnut.2025.03.014.
Liu, X., Dhumal, D., Santofimia-Castaño, P., Liu, J., Casanova, M., Garcia-Muñoz, A.C., Perles-Barbacaru, T.-A., Elkihel, A., Zhang, W., Roussel, T., Galanakou, C., Wu, J., Zerva, E., Dusetti, N., Xia, Y., Liang, X.-J., Viola, A., Iovanna, J.L. and Peng, L. (2025) “Self-assembling dendrimer nanodrug formulations for decreased hERG-related toxicity and enhanced therapeutic efficacy,” Science Advances, 11(26), p. eadu9948. Available at: https://doi.org/10.1126/sciadv.adu9948.
Antoniadis, J., Bobot, M., Boittin, M., Barral, P.-A., Jacquier, A., Kaplanski, G., Jourde-Chiche, N. and Jarrot, P.-A. (2025) “[Abnormal renal arteriography],” La Revue De Medecine Interne, pp. S0248-8663(25)00653–8. Available at: https://doi.org/10.1016/j.revmed.2025.06.005.
Küstner, T., Haast, R., Priovoulos, N., Clement, P. and Dos Santos, D.P. (2025) “ESMRMB 2025 focus topic: cycle of quality-from concept to clinical and scientific impact,” Magma (New York, N.Y.) [Preprint]. Available at: https://doi.org/10.1007/s10334-025-01272-0.
Mostame, P., Wirsich, J., Alderson, T., Ridley, B., Giraud, A.-L., Carmichael, D.W., Vulliemoz, S., Guye, M., Lemieux, L. and Sadaghiani, S. (2025) “A multiplex of connectome trajectories enables several connectivity patterns in parallel,” eLife, 13, p. RP98777. Available at: https://doi.org/10.7554/eLife.98777.
Bouleti, C., Bejan-Angoulvant, T., Servoz, C., Carsten, E., Genet, T., Ternacle, J., Deux, J.-F., Puymirat, E., Mousseaux, E., Alos, B., Garcia, R., Bonnet, G., Jacquier, A., Lattuca, B., Huttin, O., Akodad, M., Redheuil, A., Angoulvant, D., Ou, P. and MyocarditIRM Investigators (2025) “Contemporary Epidemiology, Management, and In-Hospital Outcomes of Acute Myocarditis: The Prospective Multicenter MyocarditIRM Study,” JACC. Heart failure, 13(8), p. 102492. Available at: https://doi.org/10.1016/j.jchf.2025.03.038.
Jouenne, A., Sourdon, J., Varlet, I., Vilmen, C., Kober, F., Landrier, J.F., Bernard, M. and Desrois, M. (2025) “Resveratrol protection against cardiac remodeling and ischemia-reperfusion injury associated with hepatic lipid metabolism ameliorations and adipose tissue autotaxin pathway inhibition in a diet induced prediabetic female rat model,” The Journal of Nutritional Biochemistry, p. 109992. Available at: https://doi.org/10.1016/j.jnutbio.2025.109992.
Verdu-Diaz, J., Bolano-Díaz, C., Gonzalez-Chamorro, A., Fitzsimmons, S., Warman-Chardon, J., Kocak, G.S., Mucida-Alvim, D., Smith, I.C., Vissing, J., Poulsen, N.S., Luo, S., Domínguez-González, C., Bermejo-Guerrero, L., Gomez-Andres, D., Sotoca, J., Pichiecchio, A., Nicolosi, S., Monforte, M., Brogna, C., Mercuri, E., Bevilacqua, J.A., Díaz-Jara, J., Pizarro-Galleguillos, B., Krkoska, P., Alonso-Pérez, J., Olivé, M., Niks, E.H., Kan, H.E., Lilleker, J., Roberts, M., Buchignani, B., Shin, J., Esselin, F., Le Bars, E., Childs, A.M., Malfatti, E., Sarkozy, A., Perry, L., Sudhakar, S., Zanoteli, E., Di Pace, F.T., Matthews, E., Attarian, S., Bendahan, D., Garibaldi, M., Fionda, L., Alonso-Jiménez, A., Carlier, R., Okhovat, A.A., Nafissi, S., Nalini, A., Vengalil, S., Hollingsworth, K., Marini-Bettolo, C., Straub, V., Tasca, G., Bacardit, J., Díaz-Manera, J. and Myo‐Guide Consortium (2025) “Myo-Guide: A Machine Learning-Based Web Application for Neuromuscular Disease Diagnosis With MRI,” Journal of Cachexia, Sarcopenia and Muscle, 16(3), p. e13815. Available at: https://doi.org/10.1002/jcsm.13815.
Uher, D., Drenthen, G.S., Hoeberigs, C.M., van Lanen, R.H.G.J., Colon, A.J., Haast, R.A.M., van Kranen-Mastenbroek, V.H.J.M., Widman, G., Hofman, P.A.M., Wagner, L.G., Beckervordersandforth, J.C., Jansen, J.F.A., Schijns, O.E.M.G., Backes, W.H. and ACE study group (2025) “The role of ultra-high field MRI and image processing in the presurgical workup in MRI-negative focal epilepsy: A validated 7T MRI case study,” Epilepsy & Behavior Reports, 30, p. 100761. Available at: https://doi.org/10.1016/j.ebr.2025.100761.
Joppin, V., Bendahan, D., Ahmadi, A.A.E., Masson, C. and Bege, T. (2025) “Biomechanics of the abdominal wall before and after ventral hernia repair using dynamic MRI,” Hernia: The Journal of Hernias and Abdominal Wall Surgery, 29(1), p. 185. Available at: https://doi.org/10.1007/s10029-025-03337-4.
Jacquier, A., Tacher, V., Vidal, V., Kobeiter, H., Luciani, A., Boyer, L., Société Française d’imagerie cardiovasculaire diagnostique et interventionnelle (SFICV), Fédération de radiologie interventionnelle (FRI), Société Francaise de radiologie (SFR) and Conseil National Professionnel de Radiologie (G4) (2025) “Response to ‘2024 Global Statement Defining Interventional Radiology: Have We Reached the Tipping Point?,’” Cardiovascular and Interventional Radiology [Preprint]. Available at: https://doi.org/10.1007/s00270-025-04049-z.
Alonso-Ortiz, E., Papp, D., Barry, R.L., Poëti, K., Seifert, A.C., Gilbert, K.M., Lopez-Rios, N., Paska, J., Eippert, F., Weiskopf, N., Beghini, L., Graedel, N.N., Trampel, R., Callaghan, M.F., Aigner, C.S., Freund, P., Seif, M., Destruel, A., Callot, V., Vannesjo, J. and Cohen-Adad, J. (2025) “Multi-center benchmarking of cervical spinal cord RF coils for 7 T MRI: A traveling spines study,” Magnetic Resonance in Medicine [Preprint]. Available at: https://doi.org/10.1002/mrm.30551.
Mourre, H., Makhalova, J., Soncin, L., Garnier, E., Dary, H., Le Troter, A., Haast, R.A.M., Testud, B., Arthuis, M., Villalon, S.M., Lagarde, S., Pizzo, F., Bénar, C., Ranjeva, J.-P., Guye, M. and Bartolomei, F. (2025) “Nuclei-Specific Amygdala Enlargement Is Linked to Psychiatric Comorbidities in Drug-Resistant Focal Epilepsy,” Annals of Clinical and Translational Neurology [Preprint]. Available at: https://doi.org/10.1002/acn3.70071.
Plaindoux, A., Fur, Y.L., Courivaud, C., Beets, C., Samalens, L., Valette, J., Lemasson, B., Barbier, E.L., Stupar, V. and Fauvelle, F. (2025) “Mapping GABA+/Glx in experimental temporal lobe epilepsy using edited-MRSI at 9.4T,” NeuroImage, p. 121274. Available at: https://doi.org/10.1016/j.neuroimage.2025.121274.
Marignier, R., Villacieros-Álvarez, J., Espejo, C., Arrambide, G., Fissolo, N., Gutiérrez, L., Dinoto, A., Mulero, P., Rubio-Flores, L., Nieto, P., Alcalá, C., Meca-Lallana, J.E., Martínez-Garcia, P., Millán, J., Bernard-Valnet, R., González, I., Orvíz García, A., Tellez, R., Navarro, L., Presas-Rodríguez, S., Romero-Pinel, L., Martínez-Yélamos, S., Cuello, J.P., Alonso Torres, A.M., Piñar, R., Álvarez Bravo, G., Benyahya, L., Trouillet-Assant, S., Dyon-Tafani, V., Froment Tilikete, C., Ruet, A., Bourre, B., Deschamps, R., Papeix, C., Maillart, E., Kerschen, P., Ayrignac, X., Rovira, A., Auger, C., Audoin, B., Montalban, X., Tintore, M., Mariotto, S. and Cobo-Calvo, A. (2025) “Assessment of neuronal and glial serum biomarkers in myelin oligodendrocyte glycoprotein antibody-associated disease: the MULTIMOGAD study,” Journal of Neurology, Neurosurgery, and Psychiatry, p. jnnp-2024-335137. Available at: https://doi.org/10.1136/jnnp-2024-335137.
Cohen, M., Rollot, F., Debouverie, M., Zephir, H., Vukusic, S., De Seze, J., Labauge, P., Landes-Chateau, C., Mondot, L., Levraut, M., Ruet, A., Berger, E., Laplaud, D., Ciron, J., Bourre, B., Le Page, E., Papeix, C., Thouvenot, E., Al Khedr, A., Stankoff, B., Pelletier, J., Maillart, E., Casez, O., Moreau, T., Defer, G., Clavelou, P., Cabre, P., Moulin, S., Neau, J.P., Zedet, M., Hankiewicz, K., Doghri, I., Nasr, H.B., Pottier, C., Magy, L., Boulos, D.D., Heinzlef, O., Camdessanche, J.P., Coustans, M., Nifle, C., Brassat, D., Casey, R., Lebrun-Frenay, C. and OFSEP and SFSEP study groups (2025) “Secondary progression activity monitoring in MS despite an early highly active treatment the SPAM study,” European Journal of Neurology, 32(5), p. e16583. Available at: https://doi.org/10.1111/ene.16583.
Cotinat, M., Messaoudi, N., Robinet, E., Suissa, L., Doche, E., Guye, M., Audoin, B., Bensoussan, L., Ranjeva, J.-P. and Zaaraoui, W. (2025) “Dynamics of Ionic and Cytotoxic Edema During Acute and Subacute Stages of Patients With Ischemic Stroke: Complementarity of 23Na MRI and Diffusion MRI,” NMR in biomedicine, 38(5), p. e70028. Available at: https://doi.org/10.1002/nbm.70028.
Demortiere, S., Stolowy, N., Perriguey, M., Boutiere, C., Rico, A., Hilezian, F., Ndjomo-Ndjomo, B.-R., Durozard, P., Stellmann, J.-P., Marignier, R., Boucraut, J., Pelletier, J., Maarouf, A. and Audoin, B. (2025) “Diagnostic Utility of Kappa Free Light Chain Index in Adults With Inaugural Optic Neuritis,” Neurology(R) Neuroimmunology & Neuroinflammation, 12(3), p. e200386. Available at: https://doi.org/10.1212/NXI.0000000000200386.
Pennec, V.L., Douane, F., Brun, J.L., Thouveny, F., Martinelli, T., Bravetti, M., Mastier, C., Le Bras, Y., Rogopoulos, A., Barral, P.A., Marret, H., Chabrot, P., Jacquier, A., Senechal, Q., Doppelt, G. and Frandon, J. (2025) “Endovascular management of pelvic congestion syndrome: An expert consensus statement from the French Society of Cardiovascular Imaging (SFICV), Interventional Radiology Federation (FRI), College of French Radiology Teachers (CERF), and French Society of Women’s Imaging (SIFEM),” Diagnostic and Interventional Imaging, pp. S2211-5684(25)00075–0. Available at: https://doi.org/10.1016/j.diii.2025.04.004.
Dollomaja, B., Wang, H.E., Guye, M., Makhalova, J., Bartolomei, F. and Jirsa, V.K. (2025) “Virtual epilepsy patient cohort: Generation and evaluation,” PLoS computational biology, 21(4), p. e1012911. Available at: https://doi.org/10.1371/journal.pcbi.1012911.
Cotinat, M., Robinet, E., Messaoudi, N., Suissa, L., Doche, E., Guye, M., Bensoussan, L., Zaaraoui, W. and Ranjeva, J.-P. (2025) “Added Value of Sodium MR Imaging and Proton MR Spectroscopy to Conventional MR Imaging for a Better Characterization of the Ischemic Stroke: A Narrative Review,” Magnetic resonance in medical sciences: MRMS: an official journal of Japan Society of Magnetic Resonance in Medicine [Preprint]. Available at: https://doi.org/10.2463/mrms.rev.2025-0002.
Hong, J., Gaubert, M., Lefort, M., Ferré, J.C., Le Page, E., Michel, L., Labauge, P., Pelletier, J., de Seze, J., Durand-Dubief, F., Cotton, F., Edan, G., Bannier, E., Combès, B. and Kerbrat, A. (2025) “Limited added value of systematic spinal cord MRI vs brain MRI alone to classify patients with MS as active or inactive during follow-up,” Journal of Neurology, 272(4), p. 316. Available at: https://doi.org/10.1007/s00415-025-13068-2.
Lodé, B., Hussein, B.R., Meurée, C., Walsh, R., Gaubert, M., Lassalle, N., Courbon, G., Martin, A., Le Bars, J., Durand-Dubief, F., Bourre, B., Maarouf, A., Outteryck, O., Mehier, C., Poulin, A., Cathelineau, C., Hong, J., Criton, G., Motillon-Alonso, S., Lecler, A., Charbonneau, F., Duron, L., Bani-Sadr, A., Delpierre, C., Ferré, J.-C., Edan, G., Cotton, F., Casey, R., Galassi, F., Combès, B. and Kerbrat, A. (2025) “Evaluation of a deep learning segmentation tool to help detect spinal cord lesions from combined T2 and STIR acquisitions in people with multiple sclerosis,” European Radiology [Preprint]. Available at: https://doi.org/10.1007/s00330-025-11541-0.
Piazzola, C., Graillon, T., Girard, N., Dufour, H., Brue, T. and Castinetti, F. (2025) “Desmopressin is a safe and effective secretagogue to replace corticotropin-releasing hormone in petrosal sinus sampling,” Annales d’Endocrinologie, 86(2), p. 101678. Available at: https://doi.org/10.1016/j.ando.2024.101678.