Structural and functional connectome: Impact of the circadian rhythm, biological sex, and age

Research Works

Principal investigators :  Armelle Lokossou, Angèle Viola, Adriana Perles-Barbacaru, Christophe Bernard (INS)

Members

Giovanni Rabuffo (INS)

Alicia Camino

Research

Diffusion Tensor MRI (DTI) and Resting State Functional MRI (rs-fMRI) are performed to compute the structural and the functional connectome under different environmental conditions (such as lighting, circadian rhythm, sleep cycle), age and sex, as well as under pathological conditions (models of infectious diseases) to elucidate possible confounding factors. Alterations in the functional connectome due to lesions of the structural connectome are predicted using “The Virtual Mouse Brain” model in collaboration with Christophe Bernard from the “Institut de Neurosciences des Systèmes”.