Grimaldi Stephan

STEPHAN.GRIMALDI@ap-hm.fr
Phone : +33491384807

CNS

Medical Doctor (MD)
at AMU and at AP-HM

MD-PhD
leader of the Parkinson’s Disease and Movement Disorders project

Detailed Activities

Stephan Grimaldi is a neurologist (MD) in the department of Neurology and Movement Disorders headed by Prof. Azulay at the University Hospital La Timone in Marseille. In parallel to his clinical and teaching activities at Aix-Marseille University, he completed his PhD at the CRMBM-CEMEREM under the supervision of Prof. Guye Maxime (MD, PhD, Deputy director of the CRMBM and director of the CEMEREM) and Prof. Eusebio Alexandre (MD, PhD, Prof. of Neurology in the Movement Disorders department). He then held a research fellow position in the Brainstem Imaging Lab led by Dr. Bianciardi Marta at the Athinoula A. Martinos Center, Boston, Massachusetts General hospital, Harvard Medical School. Back to the CRMBM-CEMEREM, he is responsible for several projects that aim to further identify early biomarkers of neurodegeneration related to Parkinson’s disease (PD), REM-sleep Behavior Disorders, atypical parkinsonism and other movement disorders. These biomarkers are studied to better understand the underlying pathophysiology and facilitate an early differential diagnosis between PD and other clinically related disorders using 7T brain MRI. They focus on the evaluation of brain tissue microstructure (basal ganglia and brainstem), ion homeostasis (sodium) and connectivity. Then, correlations with clinical symptoms (motor, dysautonomic and cognitive) are looked for.

Keywords

Parkinson Disease, Atypical Parkinsonism
Progressive supranuclear palsy
Movement Disorders
REM-sleep Behavior Disorders
early biomarkers of neurodegeneration, Ultra-high field MRI, Sodium homeostasis, Sodium MRI

Research Projects

Parkinson’s Disease and Movement Disorders

Publications :

180164 Grimaldi 1 harvard-cite-them-right-no-et-al 50 date desc year 5028 https://crmbm.univ-amu.fr/wp-content/plugins/zotpress/

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Grass, L., Grimaldi, S. and Damier, P. (2025) “Prodromal Parkinson’s disease,” Revue Neurologique, 181(9), pp. 863–880. Available at: https://doi.org/10.1016/j.neurol.2025.06.012.

Mira, V., Stellman, J.P. and Grimaldi, S. (2025) “Paroxysmal Dystonia: An Etiology Not to Be Missed in an Older Adult Patient,” Movement Disorders Clinical Practice [Preprint]. Available at: https://doi.org/10.1002/mdc3.70407.

Desjardins, C., Grimaldi, S., Luo, S., Yu, L., Goetz, C.G., Stebbins, G.T., Martinez-Martin, P., Kurtis, M.M., Mestre, T.A., Sanchez-Ferro, A., Tosin, M.H.S., Balestrino, R., Lin, C.-Y.R., Gasca-Salas, C., Witjas, T., Colin, O., Maltete, D., Defebvre, L., Giordana, C., Charif, M., Thiriez, C., Laurencin, C., Tir, M., Dupont, G., Remy, P., Tranchant, C., Drapier, S., Samier, A., Benatru, I., Sambin, S., Corvol, J.-C., Khelifi, F., Fabbri, M., Rascol, O. and the NS-Part Cohort study group and the MDS COA Translation Steering Committee (2025) “Validation of the French Translation of the Movement Disorder Society Non-Motor Symptoms Scale (MDS-NMS) in Parkinson’s Disease,” Movement Disorders Clinical Practice, n/a(n/a). Available at: https://doi.org/10.1002/mdc3.70323.

Testud, B., Guye, M., Witjas, T. and Grimaldi, S. (2024) “Iron overload revealing the cytoarchitecture of the red nucleus: A case study,” Revue Neurologique, pp. S0035-3787(24)00660-X. Available at: https://doi.org/10.1016/j.neurol.2024.11.001.

Horowitz, T., Grimaldi, S., Dufour, H., Graillon, T., Azulay, J.-P. and Guedj, E. (2024) “18F-FDG brain PET: a metabolic predictive factor for gait improvement after cerebrospinal fluid shunting in normal pressure hydrocephalus?,” The quarterly journal of nuclear medicine and molecular imaging: official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of..., 68(3), pp. 179–86. Available at: https://doi.org/10.23736/S1824-4785.24.03582-9.

Grimaldi, S., Le Troter, A., El Mendili, M.M., Dary, H., Azulay, J.-P., Zaaraoui, W., Ranjeva, J.-P., Eusebio, A., de Rochefort, L. and Guye, M. (2024) “Energetic dysfunction and iron overload in early Parkinson’s disease: Two distinct mechanisms?,” Parkinsonism & Related Disorders, 124, p. 106996. Available at: https://doi.org/10.1016/j.parkreldis.2024.106996.

Horowitz, T., Guedj, E., Eusebio, A., Fluchère, F., Azulay, J.-P., Delmont, E. and Grimaldi, S. (2024) “Molecular Imaging in CANVAS: A Contribution for Differential Diagnosis?,” Movement Disorders Clinical Practice, 11(7), pp. 879–885. Available at: https://doi.org/10.1002/mdc3.14041.

Grimaldi, S., Eusebio, A., Carron, R., Regis, J.-M., Velly, L., Azulay, J.-P. and Witjas, T. (2023) “Deep Brain Stimulation–Withdrawal Syndrome in Parkinson’s Disease: Risk Factors and Pathophysiological Hypotheses of a Life-Threatening Emergency,” Neuromodulation, 26(2), pp. 424–434. Available at: https://doi.org/10.1016/j.neurom.2022.09.008.

Horowitz, T., Grimaldi, S., Azulay, J.-P. and Guedj, E. (2022) “Molecular imaging in Parkinsonism: The essential for clinical practice and future perspectives,” Revue Neurologique, 178(5), pp. 484–489. Available at: https://doi.org/10.1016/j.neurol.2022.03.002.

Grimaldi, S., El Mendili, M.M., Zaaraoui, W., Ranjeva, J.-P., Azulay, J.-P., Eusebio, A. and Guye, M. (2021) “Increased Sodium Concentration in Substantia Nigra in Early Parkinson’s Disease: A Preliminary Study With Ultra-High Field (7T) MRI,” Frontiers in Neurology, 12, p. 715618. Available at: https://doi.org/10.3389/fneur.2021.715618.

Kapoor, R., Ho, P.-R., Campbell, N., Chang, I., Deykin, A., Forrestal, F., Lucas, N., Yu, B., Arnold, D.L., Freedman, M.S., Goldman, M.D., Hartung, H.-P., Havrdová, E.K., Jeffery, D., Miller, A., Sellebjerg, F., Cadavid, D., Mikol, D., Steiner, D., Bartholomé, E., D’Hooghe, M., Pandolfo, M., Van Wijmeersch, B., Bhan, V., Blevins, G., Brunet, D., Devonshire, V., Duquette, P., Freedman, M., Grand’Maison, F., Jacques, F., Lapierre, Y., Lee, L., Morrow, S., Yeung, M., Dufek, M., Havrdová, E.K., Kanovsky, P., Stetkarova, I., Talabova, M., Frederiksen, J., Kant, M., Petersen, T., Ravnborg, M., Sellebjerg, F., Airas, L., Elovaara, I., Eralinna, J.-P., Sarasoja, T., Al Khedr, A., Brassat, D., Brochet, B., Camu, W., Debouverie, M., Laplaud, D., Lebrun Frenay, C., Pelletier, J., Vermersch, P., Vukusi, S., Baum, K., Berthele, A., Faiss, J., Flachenecker, P., Hohlfeld, R., Krumbholz, M., Lassek, C., Maeurer, M., Meuth, S., Ziemssen, T., Hardiman, O., McGuigan, C., Achiron, A., Karussis, D., Bergamaschi, R., Morra, V.B., Comi, G., Cottone, S., Grimaldi, L., Mancardi, G.L., Massacesi, L., Nocentini, U., Salvetti, M., Scarpini, E., Sola, P., Tedeschi, G., Trojano, M., Zaffaroni, M., Frequin, S., Hupperts, R., Killestein, J., Schrijver, H., Van Dijl, R., van Munster, E., Czarnecki, M., Drozdowski, W., Fryze, W., Hertmanowska, H., Ilkowski, J., Kaminska, A., Klodowska-Duda, G., Maciejowski, M., Motta, E., Podemski, R., Potemkowski, A., Rog, T., Selmaj, K., Stelmasiak, Z., Stepien, A., Tutaj, A., Zaborski, J., Boyko, A., Chefranova, Z., Evdoshenko, E., Khabirov, F., Sivertseva, S., Yakupov, E., Alvarez Cermeño, J.C., Escartin, A., Fernandez, O.F., Garcia-Merino, A., Hernandez Perez, M.A., Ayuso, G.I., Lallana, J.M., Gairin, X.M., Oreja-Guevara, C., Saiz Hinarejos, A., Gunnarsson, M., Lycke, J., Martin, C., Piehl, F., Roshanisefat, H., Sundstrom, P., Duddy, M., Gran, B., Harrower, T., Hobart, J., Kapoor, R., Lee, M., Mattison, P., Nicholas, R., Pearson, O., Rashid, W., Rog, D., Sharrack, B., Silber, E., Turner, B., Williams, A., Woolmore, J., Young, C., Bandari, D., Berger, J., Camac, A., Cohan, S., Conway, J., Edwards, K., Fabian, M., Florin, J., Freedman, S., Garwacki, D., Goldman, M., Harrison, D., Herrman, C., Huang, D., Javed, A., Jeffery, D., Kamin, S., Katsamakis, G., Khatri, B., Langer-Gould, A., Lynch, S., Mattson, D., Miller, T., Miravalle, A., Moses, H., Muley, S., Napier, J., Nielsen, A., Pachner, A., Pardo, G., Picone, M., Robertson, D., Royal, W., Sheppard, C., Thrower, B., Twyman, C., Waubant, E., Wendt, J., Yadav, V., Zabad, R. and Zarelli, G. (2018) “Effect of natalizumab on disease progression in secondary progressive multiple sclerosis (ASCEND): a phase 3, randomised, double-blind, placebo-controlled trial with an open-label extension,” The Lancet Neurology, 17(5), pp. 405–415. Available at: https://doi.org/10.1016/S1474-4422(18)30069-3.

Kappos, L., Bar-Or, A., Cree, B.A.C., Fox, R.J., Giovannoni, G., Gold, R., Vermersch, P., Arnold, D.L., Arnould, S., Scherz, T., Wolf, C., Wallström, E., Dahlke, F., Achiron, A., Achtnichts, L., Agan, K., Akman-Demir, G., Allen, A.B., Antel, J.P., Antiguedad, A.R., Apperson, M., Applebee, A.M., Ayuso, G.I., Baba, M., Bajenaru, O., Balasa, R., Balci, B.P., Barnett, M., Bass, A., Becker, V.U., Bejinariu, M., Bergh, F.T., Bergmann, A., Bernitsas, E., Berthele, A., Bhan, V., Bischof, F., Bjork, R.J., Blevins, G., Boehringer, M., Boerner, T., Bonek, R., Bowen, J.D., Bowling, A., Boyko, A.N., Boz, C., Bracknies, V., Braune, S., Brescia Morra, V., Brochet, B., Brola, W., Brownstone, P.K., Brozman, M., Brunet, D., Buraga, I., Burnett, M., Buttmann, M., Butzkueven, H., Cahill, J., Calkwood, J.C., Camu, W., Cascione, M., Castelnovo, G., Centonze, D., Cerqueira, J., Chan, A., Cimprichova, A., Cohan, S., Comi, G., Conway, J., Cooper, J.A., Corboy, J., Correale, J., Costell, B., Cottrell, D.A., Coyle, P.K., Craner, M., Cui, L., Cunha, L., Czlonkowska, A., da Silva, A.M., de Sa, J., de Seze, J., Debouverie, M., Debruyne, J., Decoo, D., Defer, G., Derfuss, T., Deri, N.H., Dihenia, B., Dioszeghy, P., Donath, V., Dubois, B., Duddy, M., Duquette, P., Edan, G., Efendi, H., Elias, S., Emrich, P.J., Estruch, B.C., Evdoshenko, E.P., Faiss, J., Fedyanin, A.S., Feneberg, W., Fermont, J., Fernandez, O.F., Ferrer, F.C., Fink, K., Ford, H., Ford, C., Francia, A., Freedman, M., Frishberg, B., Galgani, S., Garmany, G.P., Gehring, K., Gitt, J., Gobbi, C., Goldstick, L.P., Gonzalez, R.A., Grandmaison, F., Grigoriadis, N., Grigorova, O., Grimaldi, L.M.E., Gross, J., Gross-Paju, K., Gudesblatt, M., Guillaume, D., Haas, J., Hancinova, V., Hancu, A., Hardiman, O., Harmjanz, A., Heidenreich, F.R., Hengstman, G.J.D., Herbert, J., Herring, M., Hodgkinson, S., Hoffmann, O.M., Hofmann, W.E., Honeycutt, W.D., Hua, L.H., Huang, Dehui, Huang, Y., Huang, DeRen, Hupperts, R., Imre, P., Jacobs, A.K., Jakab, G., Jasinska, E., Kaida, K., Kalnina, J., Kaprelyan, A., Karelis, G., Karussis, D., Katz, A., Khabirov, F.A., Khatri, B., Kimura, T., Kister, I., Kizlaitiene, R., Klimova, E., Koehler, J., Komatineni, A., Kornhuber, A., Kovacs, K., Koves, A., Kozubski, W., Krastev, G., Krupp, L.B., Kurca, E., Lassek, C., Laureys, G., Lee, L., Lensch, E., Leutmezer, F., Li, H., Linker, R.A., Linnebank, M., Liskova, P., Llanera, C., Lu, J., Lutterotti, A., Lycke, J., Macdonell, R., Maciejowski, M., Maeurer, M., Magzhanov, R.V., Maida, E.-M., Malciene, L., Mao-Draayer, Y., Marfia, G.A., Markowitz, C., Mastorodimos, V., Matyas, K., Meca-Lallana, J., Merino, J.A.G., Mihetiu, I.G., Milanov, I., Miller, A.E., Millers, A., Mirabella, M., Mizuno, M., Montalban, X., Montoya, L., Mori, M., Mueller, S., Nakahara, J., Nakatsuji, Y., Newsome, S., Nicholas, R., Nielsen, A.S., Nikfekr, E., Nocentini, U., Nohara, C., Nomura, K., Odinak, M.M., Olsson, T., van Oosten, B.W., Oreja-Guevara, C., Oschmann, P., Overell, J., Pachner, A., Panczel, G., Pandolfo, M., Papeix, C., Patrucco, L., Pelletier, J., Piedrabuena, R., Pless, M., Polzer, U., Pozsegovits, K., Rastenyte, D., Rauer, S., Reifschneider, G., Rey, R., Rizvi, S.A., Robertson, D., Rodriguez, J.M., Rog, D., Roshanisefat, H., Rowe, V., Rozsa, C., Rubin, S., Rusek, S., Saccà, F., Saida, T., Salgado, A.V., Sanchez, V.E.F., Sanders, K., Satori, M., Sazonov, D.V., Scarpini, E.A., Schlegel, E., Schluep, M., Schmidt, S., Scholz, E., Schrijver, H.M., Schwab, M., Schwartz, R., Scott, J., Selmaj, K., Shafer, S., Sharrack, B., Shchukin, I.A., Shimizu, Y., Shotekov, P., Siever, A., Sigel, K.-O., Silliman, S., Simo, M., Simu, M., Sinay, V., Siquier, A.E., Siva, A., Skoda, O., Solomon, A., Stangel, M., Stefoski, D., Steingo, B., Stolyarov, I.D., Stourac, P., Strassburger-Krogias, K., Strauss, E., Stuve, O., Tarnev, I., Tavernarakis, A., Tello, C.R., Terzi, M., Ticha, V., Ticmeanu, M., Tiel-Wilck, K., Toomsoo, T., Tubridy, N., Tullman, M.J., Tumani, H., Turcani, P., Turner, B., Uccelli, A., Urtaza, F.J.O., Vachova, M., Valikovics, A., Walter, S., Van Wijmeersch, B., Vanopdenbosch, L., Weber, J.R., Weiss, S., Weissert, R., Vermersch, P., West, T., Wiendl, H., Wiertlewski, S., Wildemann, B., Willekens, B., Visser, L.H., Vorobeychik, G., Xu, X., Yamamura, T., Yang, Y.N., Yelamos, S.M., Yeung, M., Zacharias, A., Zelkowitz, M., Zettl, U., Zhang, M., Zhou, H., Zieman, U. and Ziemssen, T. (2018) “Siponimod versus placebo in secondary progressive multiple sclerosis (EXPAND): a double-blind, randomised, phase 3 study,” The Lancet, 391(10127), pp. 1263–1273. Available at: https://doi.org/10.1016/S0140-6736(18)30475-6.

Grimaldi, S., Duprat, L., Grapperon, A.-M., Verschueren, A., Delmont, E. and Attarian, S. (2017) “Global motor unit number index sum score for assessing the loss of lower motor neurons in amyotrophic lateral sclerosis,” Muscle & Nerve, 56(2), pp. 202–206. Available at: https://doi.org/10.1002/mus.25595.