ARMAND Martine

martine.armand@inserm.fr
Phone : 33(0)491324822

Cardiovascular (CVS) imaging team.

Research Associate (PhD)

at INSERM

Senior INSERM Scientist (CRHC)

Research Associate (PhD)

Detailed Activities

After a BTS in Dietetics (1984) because Martine wished to do “short academic education in Nutrition”, she prepared a license in “Life & Health” (Biochemistry and Physiology), a Master’s degree and then a DEA in Nutrition, and finally a thesis in Sciences in speciality “Cellular Biology and Microbiology” on a Nutrition subject (Enzymatic and physico-chemical aspects of the digestion of food lipids”). Because the USA was a “teenage girl’s dream” she left 15 months for Washington DC (with an Inserm grant in her pocket) to train in Clinical Nutrition in the “Developmental Biology and Nutrition” Laboratory of Prof. Margit Hamosh at Georgetown University Hospital. Because she thought her skills could be helpful for improving people health, she postulated at INSERM, and was appointed in 1996 as an INSERM Scientist on a project related to Lipid Nutrition and Human Health. Martine works mainly in the field of omega-3 and omega-6 polyunsaturated fatty acids (PUFAs) in relation to health and the impact of an imbalance in these PUFAs and various life situations (prematurity, type 1 diabetes, cardiovascular diseases, DOHaD).

Main research areas
– Fatty acid composition of breast milk according to the mother’s status.
– fatty acids in DOHaD
– Health impact of phospholipids.
– Omega 3 index in different populations.
– Lipid metabolism in type 1 diabetic patients.

Keywords

  • Nutrition; Lipids; Omega 3 fatty acids; Phospholipids
  • Diabetes; Biochemistry
  • DOHaD
  • Premature newborns
  • Birth-Cohort Studies; biofluids NMR.

General Information

Scientific networks:
– Partner of the French birth cohort EDEN (Early Pre- and Postnatal Determinants of Psychomotor Development and Health of the Child; launched in 2003) since 2004 (https://eden.vjf.inserm.fr/research-center/9);
– Member of the group “Food and Nutrition” of French National birth cohort ELFE (French Longitudinal Study of Children; launched in 2011) since 2006 (https://www.elfe-france.fr).
– Member of French Scientific Societies (Société Française de Nutrition – SFN since 1994, SF-DOHaD since 2011), International Societies (ISSFAL since 2010; ASN since November 2016).
– Expert in Nutrition for the Scientific Committee of the French Cystic Fibrosis Association (VLM) since 2013.

Teaching

Teaching (Nutrition, Biochemistry, Metabolism):
In charge of lecture in Nutrition in Marseille, i.e., from 1999-2014 concerning L3 level in Biochemistry (6 credits), since 2004 for the Engineers School Polytech-Sud (20 hrs/year), since 2009 for Dieticians (professional formation 2 hrs/year).

Publications :

180164 4FPAP9R9 1 harvard-cite-them-right-no-et-al 50 date desc year 2610 https://crmbm.univ-amu.fr/wp-content/plugins/zotpress/
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Quiclet, C., Armand, M., Dubouchaud, H., Vial, G., Fontaine, E., Batandier, C. and Couturier, K. (2022) “Maternal training during lactation modifies breast milk fatty acid composition and male offspring glucose homeostasis in rat,” Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1867(12), p. 159223. Available at: https://doi.org/10.1016/j.bbalip.2022.159223.
Yuan, W.L., Bernard, J.Y., Armand, M., Sarté, C., Charles, M.A. and Heude, B. (2022) “Associations of Maternal Consumption of Dairy Products during Pregnancy with Perinatal Fatty Acids Profile in the EDEN Cohort Study,” Nutrients, 14(8), p. 1636. Available at: https://doi.org/10.3390/nu14081636.
Garbi, A., Armand, M., Beltran-Anzola, A.-A., Sarté, C., Brévaut-Malaty, V., Tosello, B. and Gire, C. (2022) “Effect of Massage with Oil Balanced in Essential Fatty Acids on Development and Lipid Parameters in Very Premature Neonates: A Randomized, Controlled Study,” Children, 9(4), p. 463. Available at: https://doi.org/10.3390/children9040463.
Préau, Y., Galie, S., Schaepelynck, P., Armand, M. and Raccah, D. (2021) “Benefits of a Switch from Intermittently Scanned Continuous Glucose Monitoring (isCGM) to Real-Time (rt) CGM in Diabetes Type 1 Suboptimal Controlled Patients in Real-Life: A One-Year Prospective Study §,” Sensors (Basel, Switzerland), 21(18), p. 6131. Available at: https://doi.org/10.3390/s21186131.
Préau, Y., Armand, M., Galie, S., Schaepelynck, P. and Raccah, D. (2021) “Reply to Letter by Alexander Seibold on ‘Impact of Switching from Intermittently Scanned to Real-Time Continuous Glucose Monitoring Systems in a Type 1 Diabetes Patient French Cohort: An Observational Study of Clinical Practices’ by Yannis Préau, et al. (doi: 10.1089/dia.2020.0674),” Diabetes Technology & Therapeutics, 23(8), pp. 598–600. Available at: https://doi.org/10.1089/dia.2021.0087.
Préau, Y., Armand, M., Galie, S., Schaepelynck, P. and Raccah, D. (2021) “Impact of Switching from Intermittently Scanned to Real-Time Continuous Glucose Monitoring Systems in a Type 1 Diabetes Patient French Cohort: An Observational Study of Clinical Practices,” Diabetes Technology & Therapeutics, 23(4), pp. 259–267. Available at: https://doi.org/10.1089/dia.2020.0515.
van Rossem, L., Smit, H.A., Armand, M., Bernard, J.Y., Bisgaard, H., Bønnelykke, K., Bruun, S., Heude, B., Husby, S., Kyhl, H.B., Michaelsen, K.F., Stark, K.D., Thijs, C., Vinding, R.K., Wijga, A.H. and Lauritzen, L. (2021) “Breast milk n-3 long-chain polyunsaturated fatty acids and blood pressure: an individual participant meta-analysis,” European Journal of Nutrition, 60(2), pp. 989–998. Available at: https://doi.org/10.1007/s00394-020-02310-4.
Armand, M., Bernard, J.Y., Forhan, A., Heude, B., Charles, M.-A., Annesi-Maesano, I., Bernard, J.Y., Botton, J., Charles, M.-A., Dargent-Molina, P., Lauzon-Guillain, B. de, Ducimetière, P., Agostini, M.D., Foliguet, B., Forhan, A., Fritel, X., Germa, A., Goua, V., Hankard, R., Heude, B., Kaminski, M., Larroque, B., Lelong, N., Lepeule, J., Magnin, G., Marchand, L., Nabet, C., Pierre, F., Slama, R., Saurel-Cubizolles, M.-J., Schweitzer, M. and Thiebaugeorges, O. (2018) “Maternal nutritional determinants of colostrum fatty acids in the EDEN mother-child cohort,” Clinical Nutrition, 37(6), pp. 2127–2136. Available at: https://doi.org/10.1016/j.clnu.2017.10.007.
Bernard, J.Y., Armand, M., Peyre, H., Garcia, C., Forhan, A., De Agostini, M., Charles, M.-A. and Heude, B. (2017) “Breastfeeding, Polyunsaturated Fatty Acid Levels in Colostrum and Child Intelligence Quotient at Age 5-6 Years,” The Journal of Pediatrics, 183, pp. 43-50.e3. Available at: https://doi.org/10.1016/j.jpeds.2016.12.039.
Braud, L., Battault, S., Meyer, G., Nascimento, A., Gaillard, S., de Sousa, G., Rahmani, R., Riva, C., Armand, M., Maixent, J.-M. and Reboul, C. (2016) “Antioxidant properties of tea blunt ROS-dependent lipogenesis: beneficial effect on hepatic steatosis in a high fat-high sucrose diet NAFLD obese rat model,” The Journal of Nutritional Biochemistry, 40, pp. 95–104. Available at: https://doi.org/10.1016/j.jnutbio.2016.10.012.
Bernard, M., Maixent, J.-M., Gerbi, A., Lan, C., Cozzone, P.J., Pieroni, G., Armand, M. and Coste, T.C. (2016) “Dietary docosahexaenoic acid-enriched glycerophospholipids exert cardioprotective effects in ouabain-treated rats via physiological and metabolic changes,” Food & Function, 7(2), pp. 798–804. Available at: https://doi.org/10.1039/c5fo01300c.
Bernard, J.Y., Armand, M., Forhan, A., De Agostini, M., Charles, M.-A. and Heude, B. (2016) “Early life exposure to polyunsaturated fatty acids and psychomotor development in children from the EDEN mother-child cohort,” Ocl-Oilseeds and Fats Crops and Lipids, 23(1), p. D106. Available at: https://doi.org/10.1051/ocl/2015060.
Bernard, J.Y., Armand, M., Garcia, C., Forhan, A., De Agostini, M., Charles, M.-A. and Heude, B. (2015) “The association between linoleic acid levels in colostrum and child cognition at 2 and 3 y in the EDEN cohort,” Pediatric Research, 77(6), pp. 829–835. Available at: https://doi.org/10.1038/pr.2015.50.
Braud, L., Peyre, L., de Sousa, G., Armand, M., Rahmani, R. and Maixent, J.-M. (2015) “Effect of Brewing Duration on the Antioxidant and Hepatoprotective Abilities of Tea Phenolic and Alkaloid Compounds in a t-BHP Oxidative Stress-Induced Rat Hepatocyte Model,” Molecules (Basel, Switzerland), 20(8), pp. 14985–15002. Available at: https://doi.org/10.3390/molecules200814985.
Garcia, C., Duan, R.D., Brévaut-Malaty, V., Gire, C., Millet, V., Simeoni, U., Bernard, M. and Armand, M. (2013) “Bioactive compounds in human milk and intestinal health and maturity in preterm newborn: an overview,” Cellular and Molecular Biology (Noisy-Le-Grand, France), 59(1), pp. 108–131.
Armand, M. and Flouris, A.D. (2013) “Effects of Milk Bioactive Compounds on Health,” Cellular and Molecular Biology, 59(1), pp. 1–3.
Garcia, C., Lutz, N.W., Confort-Gouny, S., Cozzone, P.J., Armand, M. and Bernard, M. (2012) “Phospholipid fingerprints of milk from different mammalians determined by 31P NMR: towards specific interest in human health,” Food Chemistry, 135(3), pp. 1777–1783. Available at: https://doi.org/10.1016/j.foodchem.2012.05.111.
Garcia, C., Millet, V., Coste, T.C., Mimoun, M., Ridet, A., Antona, C., Simeoni, U. and Armand, M. (2011) “French mothers’ milk deficient in DHA contains phospholipid species of potential interest for infant development,” Journal of Pediatric Gastroenterology and Nutrition, 53(2), pp. 206–212. Available at: https://doi.org/10.1097/MPG.0b013e318216f1d0.
Mimoun, M., Coste, T.C., Lebacq, J., Lebecque, P., Wallemacq, P., Leal, T. and Armand, M. (2009) “Increased tissue arachidonic acid and reduced linoleic acid in a mouse model of cystic fibrosis are reversed by supplemental glycerophospholipids enriched in docosahexaenoic acid,” The Journal of Nutrition, 139(12), pp. 2358–2364. Available at: https://doi.org/10.3945/jn.109.110999.
Favé, G., Oliver, P., Mimoun, M., Millet, V., Miralles, O., Ridet, A., Gleize, B., Pico, C., Palou, A., Coste, T.C. and Armand, M. (2007) “Nutritional quality of human milk from Mediterranean lactating women: a preliminary approach towards personalised nutrition,” Genes & Nutrition, 2(1), pp. 95–98. Available at: https://doi.org/10.1007/s12263-007-0025-6.
Coste, T.C., Armand, M., Lebacq, J., Lebecque, P., Wallemacq, P. and Leal, T. (2007) “An overview of monitoring and supplementation of omega 3 fatty acids in cystic fibrosis,” Clinical Biochemistry, 40(8), pp. 511–520. Available at: https://doi.org/10.1016/j.clinbiochem.2007.01.002.
Favé, G., Coste, T.C. and Armand, M. (2004) “Physicochemical properties of lipids: new strategies to manage fatty acid bioavailability,” Cellular and Molecular Biology (Noisy-Le-Grand, France), 50(7), pp. 815–831.
Armand, M., Hamosh, M., Philpott, J.R., Resnik, A.K., Rosenstein, B.J., Hamosh, A., Perman, J.A. and Hamosh, P. (2004) “Gastric function in children with cystic fibrosis: effect of diet on gastric lipase levels and fat digestion,” Pediatric Research, 55(3), pp. 457–465. Available at: https://doi.org/10.1203/01.PDR.0000110522.78194.5B.
Pafumi, Y., Lairon, D., de la Porte, P.L., Juhel, C., Storch, J., Hamosh, M. and Armand, M. (2002) “Mechanisms of inhibition of triacylglycerol hydrolysis by human gastric lipase,” The Journal of Biological Chemistry, 277(31), pp. 28070–28079. Available at: https://doi.org/10.1074/jbc.M202839200.
Borel, P., Pasquier, B., Armand, M., Tyssandier, V., Grolier, P., Alexandre-Gouabau, M.C., Andre, M., Senft, M., Peyrot, J., Jaussan, V., Lairon, D. and Azais-Braesco, V. (2001) “Processing of vitamin A and E in the human gastrointestinal tract,” American Journal of Physiology. Gastrointestinal and Liver Physiology, 280(1), pp. G95–G103.
Juhel, C., Armand, M., Pafumi, Y., Rosier, C., Vandermander, J. and Lairon, D. (2000) “Green tea extract (AR25) inhibits lipolysis of triglycerides in gastric and duodenal medium in vitro,” The Journal of Nutritional Biochemistry, 11(1), pp. 45–51.
Armand, M., Pasquier, B., André, M., Borel, P., Senft, M., Peyrot, J., Salducci, J., Portugal, H., Jaussan, V. and Lairon, D. (1999) “Digestion and absorption of 2 fat emulsions with different droplet sizes in the human digestive tract,” The American Journal of Clinical Nutrition, 70(6), pp. 1096–1106.
Dubois, C., Beaumier, G., Juhel, C., Armand, M., Portugal, H., Pauli, A.M., Borel, P., Latgé, C. and Lairon, D. (1998) “Effects of graded amounts (0-50 g) of dietary fat on postprandial lipemia and lipoproteins in normolipidemic adults,” The American Journal of Clinical Nutrition, 67(1), pp. 31–38.
Borel, P., Mekki, N., Boirie, Y., Partier, A., Grolier, P., Alexandre-Gouabau, M.C., Beaufrere, B., Armand, M., Lairon, D. and Azais-Braesco, V. (1997) “Postprandial chylomicron and plasma vitamin E responses in healthy older subjects compared with younger ones,” European Journal of Clinical Investigation, 27(10), pp. 812–821.
Armand, M., Hamosh, M., Mehta, N.R., Angelus, P.A., Philpott, J.R., Henderson, T.R., Dwyer, N.K., Lairon, D. and Hamosh, P. (1996) “Effect of human milk or formula on gastric function and fat digestion in the premature infant,” Pediatric Research, 40(3), pp. 429–437. Available at: https://doi.org/10.1203/00006450-199609000-00011.
Dubois, C., Armand, M., Ferezou, J., Beaumier, G., Portugal, H., Pauli, A.M., Bernard, P.M., Becue, T., Lafont, H. and Lairon, D. (1996) “Postprandial appearance of dietary deuterated cholesterol in the chylomicron fraction and whole plasma in healthy subjects,” The American Journal of Clinical Nutrition, 64(1), pp. 47–52.
Armand, M., Borel, P., Pasquier, B., Dubois, C., Senft, M., Andre, M., Peyrot, J., Salducci, J. and Lairon, D. (1996) “Physicochemical characteristics of emulsions during fat digestion in human stomach and duodenum,” The American Journal of Physiology, 271(1 Pt 1), pp. G172-183.
Pasquier, B., Armand, M., Castelain, C., Guillon, F., Borel, P., Lafont, H. and Lairon, D. (1996) “Emulsification and lipolysis of triacylglycerols are altered by viscous soluble dietary fibres in acidic gastric medium in vitro,” The Biochemical Journal, 314 ( Pt 1), pp. 269–275.
Borel, P., Grolier, P., Armand, M., Partier, A., Lafont, H., Lairon, D. and Azais-Braesco, V. (1996) “Carotenoids in biological emulsions: solubility, surface-to-core distribution, and release from lipid droplets,” Journal of Lipid Research, 37(2), pp. 250–261.
Armand, M., Hamosh, M., DiPalma, J.S., Gallagher, J., Benjamin, S.B., Philpott, J.R., Lairon, D. and Hamosh, P. (1995) “Dietary fat modulates gastric lipase activity in healthy humans,” The American Journal of Clinical Nutrition, 62(1), pp. 74–80.
Dubois, C., Armand, M., Senft, M., Portugal, H., Pauli, A.M., Bernard, P.M., Lafont, H. and Lairon, D. (1995) “Chronic oat bran intake alters postprandial lipemia and lipoproteins in healthy adults,” The American Journal of Clinical Nutrition, 61(2), pp. 325–333.
Dubois, C., Armand, M., Mekki, N., Portugal, H., Pauli, A.M., Bernard, P.M., Lafont, H. and Lairon, D. (1994) “Effects of increasing amounts of dietary cholesterol on postprandial lipemia and lipoproteins in human subjects,” Journal of Lipid Research, 35(11), pp. 1993–2007.
Dubois, C., Armand, M., Azais-Braesco, V., Portugal, H., Pauli, A.M., Bernard, P.M., Latgé, C., Lafont, H., Borel, P. and Lairon, D. (1994) “Effects of moderate amounts of emulsified dietary fat on postprandial lipemia and lipoproteins in normolipidemic adults,” The American Journal of Clinical Nutrition, 60(3), pp. 374–382.
Armand, M., Borel, P., Dubois, C., Senft, M., Peyrot, J., Salducci, J., Lafont, H. and Lairon, D. (1994) “Characterization of emulsions and lipolysis of dietary lipids in the human stomach,” The American Journal of Physiology, 266(3 Pt 1), pp. G372-381.
Borel, P., Armand, M., Pasquier, B., Senft, M., Dutot, G., Melin, C., Lafont, H. and Lairon, D. (1994) “Digestion and Absorption of Tube-Feeding Emulsions With Different Droplet Sizes and Compositions in the Rat,” Journal of Parenteral and Enteral Nutrition, 18(6), pp. 534–543. Available at: https://doi.org/10.1177/0148607194018006534.
Dubois, C., Cara, L., Armand, M., Borel, P., Senft, M., Portugal, H., Pauli, A.M., Bernard, P.M., Lafont, H. and Lairon, D. (1993) “Effects of pea and soybean fibre on postprandial lipaemia and lipoproteins in healthy adults,” European Journal of Clinical Nutrition, 47(7), pp. 508–520.
Cara, L., Armand, M., Borel, P., Senft, M., Portugal, H., Pauli, A.M., Lafont, H. and Lairon, D. (1992) “Long-term wheat germ intake beneficially affects plasma lipids and lipoproteins in hypercholesterolemic human subjects,” The Journal of Nutrition, 122(2), pp. 317–326.
Cara, L., Dubois, C., Borel, P., Armand, M., Senft, M., Portugal, H., Pauli, A.M., Bernard, P.M. and Lairon, D. (1992) “Effects of oat bran, rice bran, wheat fiber, and wheat germ on postprandial lipemia in healthy adults,” The American Journal of Clinical Nutrition, 55(1), pp. 81–88.
Borel, P., Armand, M., Senft, M., Andre, M., Lafont, H. and Lairon, D. (1991) “Gastric lipase: evidence of an adaptive response to dietary fat in the rabbit,” Gastroenterology, 100(6), pp. 1582–1589.
Cara, L., Borel, P., Armand, M., Senft, M., Lafont, H., Portugal, H., Pauli, A.M., Boulze, D., Lacombe, C. and Lairon, D. (1991) “Plasma lipid lowering effects of wheat germ in hypercholesterolemic subjects,” Plant Foods for Human Nutrition (Dordrecht, Netherlands), 41(2), pp. 135–150.
Armand, M., Borel, P., Cara, L., Senft, M., Chautan, M., Lafont, H. and Lairon, D. (1990) “Adaptation of lingual lipase to dietary fat in rats,” The Journal of Nutrition, 120(10), pp. 1148–1156.