GIANNESINI Benoît
Research Associate (PhD)
at CNRSIn charge of experimental musculoskeletal models
Detailed Activities
Keywords
- Dynamic MRI/MRS
- Metabolism
- New MR Biomarkers
- Skeletal muscle function
- In vivo energy metabolism
- Preclinical studies
- Mitochondrial disorders
- Myopathies
General Information
Publications :
180164
GIANNESINI
1
harvard-cite-them-right-no-et-al
50
date
desc
year
2602
https://crmbm.univ-amu.fr/wp-content/plugins/zotpress/
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Hilezian, F., Maarouf, A., Boutiere, C., Rico, A., Demortiere, S., Kerschen, P., Sene, T., Bensa-Koscher, C., Giannesini, C., Capron, J., Mekinian, A., Camdessanché, J.-P., Androdias, G., Marignier, R., Collongues, N., Casez, O., Coclitu, C., Vaillant, M., Mathey, G., Ciron, J., Pelletier, J. and Audoin, B. (2021) “TNF-α inhibitors used as steroid-sparing maintenance monotherapy in parenchymal CNS sarcoidosis,” Journal of Neurology, Neurosurgery & Psychiatry, 92(8), pp. 890–896. Available at: https://doi.org/10.1136/jnnp-2020-325665.
Pelletier, L., Petiot, A., Brocard, J., Giannesini, B., Giovannini, D., Sanchez, C., Travard, L., Chivet, M., Beaufils, M., Kutchukian, C., Bendahan, D., Metzger, D., Franzini Armstrong, C., Romero, N.B., Rendu, J., Jacquemond, V., Fauré, J. and Marty, I. (2020) “In vivo RyR1 reduction in muscle triggers a core-like myopathy,” Acta Neuropathologica Communications, 8(1), p. 192. Available at: https://doi.org/10.1186/s40478-020-01068-4.
Roos, I., Leray, E., Frascoli, F., Casey, R., Brown, J.W.L., Horakova, D., Havrdova, E.K., Trojano, M., Patti, F., Izquierdo, G., Eichau, S., Onofrj, M., Lugaresi, A., Prat, A., Girard, M., Grammond, P., Sola, P., Ferraro, D., Ozakbas, S., Bergamaschi, R., Sá, M.J., Cartechini, E., Boz, C., Granella, F., Hupperts, R., Terzi, M., Lechner-Scott, J., Spitaleri, D., Van Pesch, V., Soysal, A., Olascoaga, J., Prevost, J., Aguera-Morales, E., Slee, M., Csepany, T., Turkoglu, R., Sidhom, Y., Gouider, R., Van Wijmeersch, B., McCombe, P., Macdonell, R., Coles, A., Malpas, C.B., Butzkueven, H., Vukusic, S., Kalincik, T., the MSBase, Duquette, P., Grand’Maison, F., Iuliano, G., Ramo-Tello, C., Solaro, C., Cabrera-Gomez, J.A., Rio, M.E., Bolaños, R.F., Shaygannejad, V., Oreja-Guevara, C., Sanchez-Menoyo, J.L., Petersen, T., Altintas, A., Barnett, M., Flechter, S., Fragoso, Y., Amato, M.P., Moore, F., Ampapa, R., Verheul, F., Hodgkinson, S., Cristiano, E., Yamout, B., Laureys, G., Dominguez, J.A., Zwanikken, C., Deri, N., Dobos, E., Vrech, C., Butler, E., Rozsa, C., Petkovska-Boskova, T., Karabudak, R., Rajda, C., Alkhaboori, J., Saladino, M.L., Shaw, C., Shuey, N., Vucic, S., Sempere, A.P., Campbell, J., Piroska, I., Taylor, B., van der Walt, A., Kappos, L., Roullet, E., Gray, O., Simo, M., Sirbu, C.-A., OFSEP investigators, Brochet, B., Cotton, F., De Sèze, J., Dion, A., Douek, P., Guillemin, F., Laplaud, D., Lebrun-Frenay, C., Moreau, T., Olaiz, J., Pelletier, J., Rigaud-Bully, C., Stankoff, B., Marignier, R., Debouverie, M., Edan, G., Ciron, J., Ruet, A., Collongues, N., Lubetzki, C., Vermersch, P., Labauge, P., Defer, G., Cohen, M., Fromont, A., Wiertlewsky, S., Berger, E., Clavelou, P., Audoin, B., Giannesini, C., Gout, O., Thouvenot, E., Heinzlef, O., Al-Khedr, A., Bourre, B., Casez, O., Cabre, P., Montcuquet, A., Créange, A., Camdessanché, J.-P., Faure, J., Maurousset, A., Patry, I., Hankiewicz, K., Pottier, C., Maubeuge, N., Labeyrie, C. and Nifle, C. (2020) “Delay from treatment start to full effect of immunotherapies for multiple sclerosis,” Brain, 143(9), pp. 2742–2756. Available at: https://doi.org/10.1093/brain/awaa231.
Warnez-Soulie, J., Macia, M., Lac, S., Pecchi, E., Bernard, M., Bendahan, D., Bartoli, M., Carrier, A. and Giannesini, B. (2019) “Tumor protein 53-induced nuclear protein 1 deficiency alters mouse gastrocnemius muscle function and bioenergetics in vivo,” Physiological Reports, 7(10), p. e14055. Available at: https://doi.org/10.14814/phy2.14055.
Durozard, P., Maarouf, A., Boutiere, C., Ruet, A., Brochet, B., Vukusic, S., Carra-Dalliere, C., Labauge, P., Mathey, G., Debouverie, M., Papeix, C., Maillart, E., Lubetzki, C., Bensa, C., Gout, O., Giannesini, C., Stankoff, B., Ciron, J., Brassat, D., Pelletier, J., Rico Lamy, A. and Audoin, B. (2019) “Efficacy of rituximab in refractory RRMS,” Multiple Sclerosis (Houndmills, Basingstoke, England), 25(6), pp. 828–836. Available at: https://doi.org/10.1177/1352458518772748.
Béchir, N., Pecchi, É., Vilmen, C., Bernard, M., Bendahan, D. and Giannesini, B. (2018) “Activin type IIB receptor blockade does not limit adenosine triphosphate supply in mouse skeletal muscle in Vivo,” Muscle & Nerve, 58(6), pp. 834–842. Available at: https://doi.org/10.1002/mus.26306.
Sébastien, M., Giannesini, B., Aubin, P., Brocard, Julie, Chivet, M., Pietrangelo, L., Boncompagni, S., Bosc, C., Brocard, Jacques, Rendu, J., Gory-Fauré, S., Andrieux, A., Fourest-Lieuvin, A., Fauré, J. and Marty, I. (2018) “Deletion of the microtubule-associated protein 6 (MAP6) results in skeletal muscle dysfunction,” Skeletal Muscle, 8(1), p. 30. Available at: https://doi.org/10.1186/s13395-018-0176-8.
Macia, M., Pecchi, E., Desrois, M., Lan, C., Vilmen, C., Portha, B., Bernard, M., Bendahan, D. and Giannesini, B. (2018) “Exercise training impacts exercise tolerance and bioenergetics in gastrocnemius muscle of non-obese type-2 diabetic Goto-Kakizaki rat in vivo,” Biochimie, 148, pp. 36–45. Available at: https://doi.org/10.1016/j.biochi.2018.02.014.
Warnez-Soulie, J., Giannesini, B., Henri, S., Richard, I., Malissen, B., Krahn, M. and Bartoli, M. (2017) “Characterization of the eosinophilic myositis caused by CAPN3 mutations on a mouse model,” Neuromuscular Disorders, 27, pp. S143–S144. Available at: https://doi.org/10.1016/j.nmd.2017.06.185.
Béchir, N., Pecchi, E., Vilmen, C., Le Fur, Y., Amthor, H., Bernard, M., Bendahan, D. and Giannesini, B. (2016) “ActRIIB blockade increases force-generating capacity and preserves energy supply in exercising mdx mouse muscle in vivo,” FASEB journal: official publication of the Federation of American Societies for Experimental Biology, 30(10), pp. 3551–3562. Available at: https://doi.org/10.1096/fj.201600271RR.
Ghiss, M., Giannesini, B., Tropiano, P., Tourki, Z. and Boiron, O. (2016) “Quantitative MRI water content mapping of porcine intervertebral disc during uniaxial compression,” Computer Methods in Biomechanics and Biomedical Engineering, 19(10), pp. 1079–1088. Available at: https://doi.org/10.1080/10255842.2015.1101072.
Béchir, N., Pecchi, É., Relizani, K., Vilmen, C., Le Fur, Y., Bernard, M., Amthor, H., Bendahan, D. and Giannesini, B. (2016) “Mitochondrial impairment induced by postnatal ActRIIB blockade does not alter function and energy status in exercising mouse glycolytic muscle in vivo,” American Journal of Physiology. Endocrinology and Metabolism, 310(7), pp. E539-549. Available at: https://doi.org/10.1152/ajpendo.00370.2015.
Abdesselam, I., Pepino, P., Troalen, T., Macia, M., Ancel, P., Masi, B., Fourny, N., Gaborit, B., Giannesini, B., Kober, F., Dutour, A. and Bernard, M. (2015) “Time course of cardiometabolic alterations in a high fat high sucrose diet mice model and improvement after GLP-1 analog treatment using multimodal cardiovascular magnetic resonance,” Journal of Cardiovascular Magnetic Resonance, 17(1), p. 95. Available at: https://doi.org/10.1186/s12968-015-0198-x.
Yashiro, K., Tonson, A., Pecchi, É., Vilmen, C., Le Fur, Y., Bernard, M., Bendahan, D. and Giannesini, B. (2015) “Capsiate Supplementation Reduces Oxidative Cost of Contraction in Exercising Mouse Skeletal Muscle In Vivo,” PloS One, 10(6), p. e0128016. Available at: https://doi.org/10.1371/journal.pone.0128016.
Macia, M., Pecchi, E., Vilmen, C., Desrois, M., Lan, C., Portha, B., Bernard, M., Bendahan, D. and Giannesini, B. (2015) “Insulin Resistance Is Not Associated with an Impaired Mitochondrial Function in Contracting Gastrocnemius Muscle of Goto-Kakizaki Diabetic Rats In Vivo,” PloS One, 10(6), p. e0129579. Available at: https://doi.org/10.1371/journal.pone.0129579.
Marcotorchino, J., Tourniaire, F., Astier, J., Karkeni, E., Canault, M., Amiot, M.-J., Bendahan, D., Bernard, M., Martin, J.-C., Giannesini, B. and Landrier, J.-F. (2014) “Vitamin D protects against diet-induced obesity by enhancing fatty acid oxidation,” The Journal of Nutritional Biochemistry, 25(10), pp. 1077–1083. Available at: https://doi.org/10.1016/j.jnutbio.2014.05.010.
Relizani, K., Mouisel, E., Giannesini, B., Hourdé, C., Patel, K., Morales Gonzalez, S., Jülich, K., Vignaud, A., Piétri-Rouxel, F., Fortin, D., Garcia, L., Blot, S., Ritvos, O., Bendahan, D., Ferry, A., Ventura-Clapier, R., Schuelke, M. and Amthor, H. (2014) “Blockade of ActRIIB signaling triggers muscle fatigability and metabolic myopathy,” Molecular Therapy: The Journal of the American Society of Gene Therapy, 22(8), pp. 1423–1433. Available at: https://doi.org/10.1038/mt.2014.90.
Kazuya, Y., Tonson, A., Pecchi, E., Dalmasso, C., Vilmen, C., Fur, Y.L., Bernard, M., Bendahan, D. and Giannesini, B. (2014) “A single intake of capsiate improves mechanical performance and bioenergetics efficiency in contracting mouse skeletal muscle,” American Journal of Physiology. Endocrinology and Metabolism, 306(10), pp. E1110-1119. Available at: https://doi.org/10.1152/ajpendo.00520.2013.
Giannesini, B., Vilmen, C., Amthor, H., Bernard, M. and Bendahan, D. (2013) “Lack of myostatin impairs mechanical performance and ATP cost of contraction in exercising mouse gastrocnemius muscle in vivo,” American journal of physiology. Endocrinology and metabolism, 305(1), pp. E33-40. Available at: https://doi.org/10.1152/ajpendo.00651.2012.
Gineste, C., De Winter, J.M., Kohl, C., Witt, C.C., Giannesini, B., Brohm, K., Le Fur, Y., Gretz, N., Vilmen, C., Pecchi, E., Jubeau, M., Cozzone, P.J., Stienen, G.J.M., Granzier, H., Labeit, S., Ottenheijm, C.A.C., Bendahan, D. and Gondin, J. (2013) “In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype,” Neuromuscular disorders: NMD, 23(4), pp. 357–369. Available at: https://doi.org/10.1016/j.nmd.2012.12.011.
Giannesini, B., Le Fur, Y., Cozzone, P.J., Verleye, M., Le Guern, M.-E. and Bendahan, D. (2011) “Citrulline malate supplementation increases muscle efficiency in rat skeletal muscle,” European journal of pharmacology, 667(1–3), pp. 100–104. Available at: https://doi.org/10.1016/j.ejphar.2011.05.068.
Gondin, J., Giannesini, B., Vilmen, C., Le Fur, Y., Cozzone, P.J. and Bendahan, D. (2011) “Effects of a single bout of isometric neuromuscular electrical stimulation on rat gastrocnemius muscle: a combined functional, biochemical and MRI investigation,” Journal of electromyography and kinesiology: official journal of the International Society of Electrophysiological Kinesiology, 21(3), pp. 525–532. Available at: https://doi.org/10.1016/j.jelekin.2011.01.006.
Giannesini, B., Vilmen, C., Le Fur, Y., Dalmasso, C., Cozzone, P.J. and Bendahan, D. (2010) “A strictly noninvasive MR setup dedicated to longitudinal studies of mechanical performance, bioenergetics, anatomy, and muscle recruitment in contracting mouse skeletal muscle,” Magnetic resonance in medicine: official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 64(1), pp. 262–270. Available at: https://doi.org/10.1002/mrm.22386.
Gondin, J., Giannesini, B., Vilmen, C., Dalmasso, C., le Fur, Y., Cozzone, P.J. and Bendahan, D. (2010) “Effects of stimulation frequency and pulse duration on fatigue and metabolic cost during a single bout of neuromuscular electrical stimulation,” Muscle & nerve, 41(5), pp. 667–678. Available at: https://doi.org/10.1002/mus.21572.
Oddoux, S., Brocard, Julie, Schweitzer, A., Szentesi, P., Giannesini, B., Brocard, Jacques, Fauré, J., Pernet-Gallay, K., Bendahan, D., Lunardi, J., Csernoch, L. and Marty, I. (2009) “Triadin deletion induces impaired skeletal muscle function,” The Journal of biological chemistry, 284(50), pp. 34918–34929. Available at: https://doi.org/10.1074/jbc.M109.022442.
Faraut, B., Giannesini, B., Matarazzo, V., Le Fur, Y., Rougon, G., Cozzone, P.J. and Bendahan, D. (2009) “Capsiate administration results in an uncoupling protein-3 downregulation, an enhanced muscle oxidative capacity and a decreased abdominal fat content in vivo,” International journal of obesity (2005), 33(12), pp. 1348–1355. Available at: https://doi.org/10.1038/ijo.2009.182.
Giannesini, B., Izquierdo, M., Le Fur, Y., Cozzone, P.J., Verleye, M., Le Guern, M.-E., Gillardin, J.-M. and Bendahan, D. (2009) “Beneficial effects of citrulline malate on skeletal muscle function in endotoxemic rat,” European journal of pharmacology, 602(1), pp. 143–147. Available at: https://doi.org/10.1016/j.ejphar.2008.11.015.
Marqueste, T., Giannesini, B., Fur, Y.L., Cozzone, P.J. and Bendahan, D. (2008) “Comparative MRI analysis of T2 changes associated with single and repeated bouts of downhill running leading to eccentric-induced muscle damage,” Journal of applied physiology (Bethesda, Md.: 1985), 105(1), pp. 299–307. Available at: https://doi.org/10.1152/japplphysiol.00738.2007.
Giannesini, B., Izquierdo, M., Dalmasso, C., Le Fur, Y., Cozzone, P.J., Verleye, M., Le Guern, M.-E., Gillardin, J.-M. and Bendahan, D. (2008) “Endotoxemia does not limit energy supply in exercising rat skeletal muscle,” Muscle & nerve, 37(4), pp. 496–504. Available at: https://doi.org/10.1002/mus.20966.
Giannesini, B., Izquierdo, M., Dalmasso, C., Le Fur, Y., Cozzone, P.J., Verleye, M., Le Guern, M.-E., Gillardin, J.-M. and Bendahan, D. (2007) “Endotoxemia causes a paradoxical intracellular pH recovery in exercising rat skeletal muscle,” Muscle & nerve, 36(4), pp. 505–514. Available at: https://doi.org/10.1002/mus.20843.
Faraut, B., Giannesini, B., Matarazzo, V., Marqueste, T., Dalmasso, C., Rougon, G., Cozzone, P.J. and Bendahan, D. (2007) “Downregulation of uncoupling protein-3 in vivo is linked to changes in muscle mitochondrial energy metabolism as a result of capsiate administration,” American journal of physiology. Endocrinology and metabolism, 292(5), pp. E1474-1482. Available at: https://doi.org/10.1152/ajpendo.00292.2006.
Giannesini, B., Izquierdo, M., Le Fur, Y., Cozzone, P.J., Fingerle, J., Himber, J., Künnecke, B., Von Kienlin, M. and Bendahan, D. (2005) “New experimental setup for studying strictly noninvasively skeletal muscle function in rat using 1H-magnetic resonance (MR) imaging and 31P-MR spectroscopy,” Magnetic resonance in medicine: official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 54(5), pp. 1058–1064. Available at: https://doi.org/10.1002/mrm.20637.
Giannesini, B., Cozzone, P.J. and Bendahan, D. (2004) “In vivo MR investigation of skeletal muscle function in small animals,” Magma (New York, N.Y.), 17(3–6), pp. 210–218. Available at: https://doi.org/10.1007/s10334-004-0080-6.
Bendahan, D., Giannesini, B. and Cozzone, P.J. (2004) “Functional investigations of exercising muscle: a noninvasive magnetic resonance spectroscopy-magnetic resonance imaging approach,” Cellular and molecular life sciences: CMLS, 61(9), pp. 1001–1015. Available at: https://doi.org/10.1007/s00018-004-3345-3.
Darques, J.L., Bendahan, D., Roussel, M., Giannesini, B., Tagliarini, F., Le Fur, Y., Cozzone, P.J. and Jammes, Y. (2003) “Combined in situ analysis of metabolic and myoelectrical changes associated with electrically induced fatigue,” Journal of applied physiology (Bethesda, Md.: 1985), 95(4), pp. 1476–1484. Available at: https://doi.org/10.1152/japplphysiol.00230.2003.
Giannesini, B., Cozzone, P.J. and Bendahan, D. (2003) “Non-invasive investigations of muscular fatigue: metabolic and electromyographic components,” Biochimie, 85(9), pp. 873–883.
Giannesini, B., Izquierdo, M., Cozzone, P.J. and Bendahan, D. (2002) “Metabolic underpinnings of the paradoxical net phosphocreatine resynthesis in contracting rat gastrocnemius muscle,” Biochimica et biophysica acta, 1553(3), pp. 223–231.
Giannesini, B., Izquierdo, M., Le Fur, Y., Cozzone, P.J. and Bendahan, D. (2001) “In vivo reduction in ATP cost of contraction is not related to fatigue level in stimulated rat gastrocnemius muscle,” The Journal of physiology, 536(Pt 3), pp. 905–915.
Giannesini, B., Izquierdo, M., Confort-Gouny, S., Cozzone, P.J. and Bendahan, D. (2001) “Time-dependent and indirect effect of inorganic phosphate on force production in rat gastrocnemius exercising muscle determined by 31P-MRS,” FEBS letters, 507(1), pp. 25–29.