PERLES-BARBACARU Teodora-Adriana

teodora.perles-barbacaru@univ-amu.fr
Phone : +33491324804

I2M

Associate Professor (PhD)

at AMU

– Teaching: Lectures and laboratory training in Physics, Neurosciences, Medical Imaging Techniques, and Preclinical Imaging

– Research topics: Evaluation of quantitative magnetic resonance imaging biomarkers for diagnosis and treatment monitoring in inflammatory, infectious, developmental, and degenerative pathologies

– Keywords: Physics, Magnetic Resonance Imaging, Imaging Biomarkers, Neuroscience, Brain Connectivity, Tissue Microstructure, Microvascularisation, Infection, Inflammation, Cancer, Neuropathologies

Associate Professor (PhD)

Download my Resume (EN)

Detailed Activities

Doctoral co-advisor:
Blood brain barrier opening by mannitol for the delivery of pharmacologic agents: a study by dynamic magnetic resonance imaging and spectroscopy
Characterization of brain sequelae in experimental cerebral malaria

Research activities:
Methodological developments in magnetic resonance imaging at the experimental, acquisition and image processing level.
Pilot experiments to study the feasibility of imaging approaches for the evaluation of basic research concepts, novel models of pathology or treatment strategies.

Responsibilities:
In charge of the PharmaScan 70/16 US MRI scanner and its equipment
Involved and in charge of scientific dissemination for pupils and the general public (Brain Awareness Week/Semaine du Cerveau, National Science Fair/Fête de la Science, DECLIC, Meeting between school teachers and researchers, etc)

Keywords

  • Connectivity
  • Dynamic MRI/MRS
  • Image Processing
  • Metabolism
  • Microstructure/architecture
  • New Contrasts
  • New MR Biomarkers
  • Perfusion Methods
  • Quantitative MRI
  • Ultra-high field MRI
  • X-Nuclei

Teaching

Lectures and laboratory training in Physics, Neurosciences, Medical Imaging Techniques, and Preclinical Imaging

Teaching activities for medical students, nurse anesthetists, medical imaging technologists, neuroscience students, IT students, speech and vision therapists at undergraduate and graduate levels.
Practical training supervisor for IT, neuroscience and biology students.

Research Projects

Publications :

180164 BJ2IN35K 1 harvard-cite-them-right-no-et-al 50 date desc year 2590 https://crmbm.univ-amu.fr/wp-content/plugins/zotpress/
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Liu, X., Dhumal, D., Santofimia-Castaño, P., Liu, J., Casanova, M., Garcia-Muñoz, A.C., Perles-Barbacaru, T.-A., Elkihel, A., Zhang, W., Roussel, T., Galanakou, C., Wu, J., Zerva, E., Dusetti, N., Xia, Y., Liang, X.-J., Viola, A., Iovanna, J.L. and Peng, L. (2025) “Self-assembling dendrimer nanodrug formulations for decreased hERG-related toxicity and enhanced therapeutic efficacy,” Science Advances, 11(26), p. eadu9948. Available at: https://doi.org/10.1126/sciadv.adu9948.
Comino Garcia Muñoz, A., Marfouk, O., Michel, C.P., Varlet, I., Royer, E., Perles-Barbacaru, T.-A. and Viola, A. (2025) “Characterization of experimental cerebral malaria by volumetric MRI A comparative study across the sexes,” PloS One, 20(8), p. e0328693. Available at: https://doi.org/10.1371/journal.pone.0328693.
Comino Garcia-Munoz, A., Varlet, I., Grau, G.E., Perles-Barbacaru, T.-A. and Viola, A. (2024) “Contribution of Magnetic Resonance Imaging Studies to the Understanding of Cerebral Malaria Pathogenesis,” Pathogens (Basel, Switzerland), 13(12), p. 1042. Available at: https://doi.org/10.3390/pathogens13121042.
Lyu, Z., Ralahy, B., Perles-Barbacaru, T.-A., Ding, L., Jiang, Y., Lian, B., Roussel, T., Liu, Xi, Galanakou, C., Laurini, E., Tintaru, A., Giorgio, S., Pricl, S., Liu, Xiaoxuan, Bernard, M., Iovanna, J., Viola, A. and Peng, L. (2024) “Self-assembling dendrimer nanosystems for specific fluorine magnetic resonance imaging and effective theranostic treatment of tumors,” Proceedings of the National Academy of Sciences of the United States of America, 121(25), p. e2322403121. Available at: https://doi.org/10.1073/pnas.2322403121.
Lokossou, H.A., Rabuffo, G., Bernard, M., Bernard, C., Viola, A. and Perles-Barbacaru, T.-A. (2024) “Impact of the day/night cycle on functional connectome in ageing male and female mice,” NeuroImage, p. 120576. Available at: https://doi.org/10.1016/j.neuroimage.2024.120576.
Tessier, A., Ruze, A.J., Varlet, I., Laïb, E.M.H., Royer, E., Bernard, M., Viola, A. and Perles-Barbacaru, T.-A. (2024) “Quantitative MRI of Gd-DOTA Accumulation in the Mouse Brain After Intraperitoneal Administration: Validation by Mass Spectrometry,” Journal of Magnetic Resonance Imaging, 60(1), pp. 316–324. Available at: https://doi.org/10.1002/jmri.29034.
Perles-Barbacaru, T.-A. (2024) “Editorial for ‘Quantitative T2 Mapping of Acute Pancreatitis,’” Journal of Magnetic Resonance Imaging, 60(6), pp. 2692–2693. Available at: https://doi.org/10.1002/jmri.29378.
Perles-Barbacaru, A.T. (2024) “Editorial for ‘Feasibility of Multiparametric Perfusion Assessment in Diabetic Foot Ulcer Using Intravoxel Incoherent Motion and Blood Oxygenation-Level Dependent MRI,’” Journal of Magnetic Resonance Imaging, 59(5), pp. 1567–1568. Available at: https://doi.org/10.1002/jmri.28953.
Ding, L., Lyu, Z., Perles-Barbacaru, T.-A., Huang, A.Y.-T., Lian, B., Jiang, Y., Roussel, T., Galanakou, C., Giorgio, S., Kao, C.-L., Liu, X., Iovanna, J., Bernard, M., Viola, A. and Peng, L. (2023) “Modular Self-Assembling Dendrimer Nanosystems for Magnetic Resonance And Multimodality Imaging of Tumors,” Advanced Materials (Deerfield Beach, Fla.), p. e2308262. Available at: https://doi.org/10.1002/adma.202308262.
Masi, B., Perles-Barbacaru, T.-A., Bernard, M. and Viola, A. (2020) “Clinical and Preclinical Imaging of Hepatosplenic Schistosomiasis,” Trends in Parasitology, 36(2), pp. 206–226. Available at: https://doi.org/10.1016/j.pt.2019.11.007.
Deruelle, T., Kober, F., Perles-Barbacaru, A., Delzescaux, T., Noblet, V., Barbier, E.L. and Dojat, M. (2020) “A Multicenter Preclinical MRI Study: Definition of Rat Brain Relaxometry Reference Maps,” Frontiers in Neuroinformatics, 14, p. 22. Available at: https://doi.org/10.3389/fninf.2020.00022.
Collignon, A., Perles-Barbacaru, A.T., Robert, S., Silvy, F., Martinez, E., Crenon, I., Germain, S., Garcia, S., Viola, A., Lombardo, D., Mas, E. and Béraud, E. (2015) “A pancreatic tumor-specific biomarker characterized in humans and mice as an immunogenic onco-glycoprotein is efficient in dendritic cell vaccination,” Oncotarget, 6(27), pp. 23462–23479.
Masi, B., Perles-Barbacaru, T.-A., Laprie, C., Dessein, H., Bernard, M., Dessein, A. and Viola, A. (2015) “In Vivo MRI Assessment of Hepatic and Splenic Disease in a Murine Model of Schistosomiasis [corrected],” PLoS neglected tropical diseases, 9(9), p. e0004036. Available at: https://doi.org/10.1371/journal.pntd.0004036.
Sarraf, M., Perles-Barbacaru, A.T., Nissou, M.F., van der Sanden, B., Berger, F. and Lahrech, H. (2015) “Rapid-Steady-State-T1 signal modeling during contrast agent extravasation: toward tumor blood volume quantification without requiring the arterial input function,” Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 73(3), pp. 1005–1014. Available at: https://doi.org/10.1002/mrm.25218.
Perles-Barbacaru, T.-A. and Lahrech, H. (2013) “Quantitative Mapping of Angiogenesis by Magnetic Resonance Imaging,” in F. Signorelli (ed.) Functional Brain Mapping and the Endeavor to Understand the Working Brain. InTech. Available at: http://www.intechopen.com/books/functional-brain-mapping-and-the-endeavor-to-understand-the-working-brain/quantitative-mapping-of-angiogenesis-by-magnetic-resonance-imaging (Accessed: September 9, 2013).
Perles-Barbacaru, A.T., Berger, F. and Lahrech, H. (2013) “Quantitative rapid steady state T1 magnetic resonance imaging for cerebral blood volume mapping in mice: Lengthened measurement time window with intraperitoneal Gd-DOTA injection,” Magnetic resonance in medicine: official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 69(5), pp. 1451–1456. Available at: https://doi.org/10.1002/mrm.24365.
Perles-Barbacaru, T.-A. and Lahrech, H. (2012) Magnetic Resonance Imaging of the Cerebral Blood Volume: Characterization of Experimental Brain Tumor Neovascularization. LAP Lambert Academic Publishing.
Perles-Barbacaru, T.-A., Procissi, D., Demyanenko, A.V. and Jacobs, R.E. (2012) “Quantitative pharmacologic MRI in mice,” NMR in biomedicine, 25(4), pp. 498–505. Available at: https://doi.org/10.1002/nbm.1760.
Perles-Barbacaru, A.T., van der Sanden, B.P.J., Farion, R. and Lahrech, H. (2012) “How stereological analysis of vascular morphology can quantify the blood volume fraction as a marker for tumor vasculature: comparison with magnetic resonance imaging,” Journal of cerebral blood flow and metabolism: official journal of the International Society of Cerebral Blood Flow and Metabolism, 32(3), pp. 489–501. Available at: https://doi.org/10.1038/jcbfm.2011.151.
Perles-Barbacaru, T.-A., Procissi, D., Demyanenko, A.V., Hall, F.S., Uhl, G.R. and Jacobs, R.E. (2011) “Quantitative pharmacologic MRI: mapping the cerebral blood volume response to cocaine in dopamine transporter knockout mice,” NeuroImage, 55(2), pp. 622–628. Available at: https://doi.org/10.1016/j.neuroimage.2010.12.048.
Zhang, X., Bearer, E.L., Perles-Barbacaru, A.T. and Jacobs, R.E. (2010) “Increased anatomical detail by in vitro MR microscopy with a modified Golgi impregnation method,” Magnetic resonance in medicine: official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 63(5), pp. 1391–1397. Available at: https://doi.org/10.1002/mrm.22322.
Lahrech, H., Perles-Barbacaru, A.-T., Aous, S., Le Bas, J.-F., Debouzy, J.-C., Gadelle, A. and Fries, P.H. (2008) “Cerebral blood volume quantification in a C6 tumor model using gadolinium per (3,6-anhydro) alpha-cyclodextrin as a new magnetic resonance imaging preclinical contrast agent,” Journal of cerebral blood flow and metabolism: official journal of the International Society of Cerebral Blood Flow and Metabolism, 28(5), pp. 1017–1029. Available at: https://doi.org/10.1038/sj.jcbfm.9600602.
Perles-Barbacaru, A.T. and Lahrech, H. (2007) “A new Magnetic Resonance Imaging method for mapping the cerebral blood volume fraction: the rapid steady-state T1 method,” Journal of cerebral blood flow and metabolism: official journal of the International Society of Cerebral Blood Flow and Metabolism, 27(3), pp. 618–631. Available at: https://doi.org/10.1038/sj.jcbfm.9600366.