Musculoskeletal System
Mission statement
The MSK group is conducting research related to Muscle energetics, Quantitative muscle MRI and Quantitative MSK MRI. A transversal project is devoted to muscle segmentation.
Regarding Muscle energetics, experiments are conducted in both humans and animal models. The corresponding topics are related to standardisation of results and protocols, metabolic effects of training, impact of muscle pathologies, metabolic control, muscle fatigue and functional effects of electrostimulation.
Quantitative investigation of muscle using MRI is mainly performed in collaboration with the Neurology Department of Prof. Attarian (Timone Hospital). The aim is to assess the validity of outcome measures for the follow-up of natural history of rare disorders affecting muscle and also to assess the efficiency of therapeutic strategy.
The MSK program is devoted to the quantitative and functional analysis of cartilage in both rheumatoid and osteo-arthritis using quantitative MRI approaches. Another topic is dedicated to microstructural analysis of bone at ultra high-field.
The transversal project related to segmentation mainly addresses the issue of an optimal supervised segmentation of individual muscles using a variety of approaches i.e. multi-atlas- based, registration-based, artificial intelligence-based…
Through national and international collaborations, we develop a multidiscplinary approach of muscle and joint function using different non invasive techniques and investigating a variety of physiological and pathophysiological conditions.
The muscle Group at CRMBM is a multidisciplinary team composed of biochemists, physiologists, physicists and clinicians.
Research Topics
Publications
180164
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Fortanier, Etienne, Marc Adrien Hostin, Constance Michel, Emilien Delmont, Marc-Emmanuel Bellemare, Maxime Guye, David Bendahan, and Shahram Attarian. “One-Year Longitudinal Assessment of Patients With CMT1A Using Quantitative MRI.” Neurology 102, no. 9 (May 14, 2024): e209277. https://doi.org/10.1212/WNL.0000000000209277.
Monestier, Laura, Jean Del Grande, Ralph Haddad, Laure Santini, Justin Michel, Arthur Varoquaux, and Nicolas Fakhry. “Correlation between MRI (DWI and DCE) and Cellularity of Parotid Gland Pleomorphic Adenomas.” European Archives of Oto-Rhino-Laryngology 281, no. 5 (May 1, 2024): 2655–65. https://doi.org/10.1007/s00405-024-08562-8.
Macchi, Robin, Yoko Kunimasa, Pascale Chavet, Baptiste Corcelle, Laura Pomportes, Camille Fazzari, Arnaud Hays, et al. “Effect of a Graded Running Race on Lower Limb Muscle Damage, Jump Performance and Muscle Soreness in Men and Women.” Scandinavian Journal of Medicine & Science in Sports 34, no. 5 (May 2024): e14643. https://doi.org/10.1111/sms.14643.
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Michel, Constance P., Laurent A. Messonnier, Benoit Giannesini, Christophe Vilmen, Joevin Sourdon, Yann Le Fur, and David Bendahan. “Endurance Training and Hydroxyurea Have Synergistic Effects on Muscle Function and Energetics in Sickle Cell Disease Mice.” Blood Cells, Molecules & Diseases 107 (March 29, 2024): 102853. https://doi.org/10.1016/j.bcmd.2024.102853.
Brui, Ekaterina A., Zilya Badrieva, Charles-Alexis de Mayenne, Stanislas Rapacchi, Thomas Troalen, and David Bendahan. “Mitigating Slice Cross-Talk in Multi-Slice Multi-Echo Spin Echo T2 Mapping.” Magnetic Resonance in Medicine 91, no. 5 (2024): 2089–2103. https://doi.org/10.1002/mrm.29987.
White, McKenzie S., Augustin C. Ogier, Thomas L. Chenevert, Elizabeth Zucker, Luke Stoneback, Constance P. Michel, Riann M. Palmieri-Smith, and Lindsey K. Lepley. “Beyond Weakness: Exploring Intramuscular Fat and Quadriceps Atrophy in ACLR Recovery.” Journal of Orthopaedic Research 42, no. 11 (2024): 2485–94. https://doi.org/10.1002/jor.25910.
Guenoun, Daphne, Theo Wirth, Damien Roche, Constance P. Michel, Pierre Daudé, Augustin C. Ogier, Christophe Chagnaud, et al. “Ultra-High Field Magnetic Resonance Imaging of the Quadriceps Tendon Enthesis in Healthy Subjects.” Surgical and Radiologic Anatomy 45, no. 8 (August 1, 2023): 1049–54. https://doi.org/10.1007/s00276-023-03175-y.
Vladimirov, Nikita, Ekaterina Brui, Anatoliy Levchuk, Walid Al-Haidri, Vladimir Fokin, Aleksandr Efimtcev, and David Bendahan. “CNN-Based Fully Automatic Wrist Cartilage Volume Quantification in MR Images: A Comparative Analysis between Different CNN Architectures.” Magnetic Resonance in Medicine 90, no. 2 (August 2023): 737–51. https://doi.org/10.1002/mrm.29671.
Graber, Matthieu, Farah Cadour, Ahmed Ali El Ahmadi, Idir Khati, Jean Del Grande, Christophe Chagnaud, Nicolas Fakhry, Maxime Guye, and Arthur Varoquaux. “Adding Automated Decision-Tree Models to Multiparametric MRI for Parotid Tumours Improves Clinical Performance.” European Journal of Radiology 166 (July 20, 2023): 110999. https://doi.org/10.1016/j.ejrad.2023.110999.
Ogier, Augustin C., Stanislas Rapacchi, and Marc-Emmanuel Bellemare. “Four-Dimensional Reconstruction and Characterization of Bladder Deformations.” Computer Methods and Programs in Biomedicine 237 (April 29, 2023): 107569. https://doi.org/10.1016/j.cmpb.2023.107569.
Michel, Constance P., David Bendahan, Benoit Giannesini, Christophe Vilmen, Yann Le Fur, and Laurent A. Messonnier. “Effects of Hydroxyurea on Skeletal Muscle Energetics and Force Production in a Sickle Cell Disease Murine Model.” Journal of Applied Physiology 134, no. 2 (February 2023): 415–25. https://doi.org/10.1152/japplphysiol.00333.2022.
Heskamp, Linda, Augustin Ogier, David Bendahan, and Arend Heerschap. “Author Correction: Whole-Muscle Fat Analysis Identifies Distal Muscle End as Disease Initiation Site in Facioscapulohumeral Muscular Dystrophy.” Communications Medicine 3, no. 1 (January 12, 2023): 6. https://doi.org/10.1038/s43856-023-00236-6.
Chivet, Mathilde, Maximilian McCluskey, Anne Sophie Nicot, Julie Brocard, Mathilde Beaufils, Diane Giovannini, Benoit Giannesini, et al. “Huntingtin Regulates Calcium Fluxes in Skeletal Muscle.” The Journal of General Physiology 155, no. 1 (January 2, 2023): e202213103. https://doi.org/10.1085/jgp.202213103.
Nassar, Jannette, Amira Trabelsi, Rula Amer, Yann Le Fur, Shahram Attarian, Dvir Radunsky, Tamar Blumenfeld-Katzir, Hayit Greenspan, David Bendahan, and Noam Ben-Eliezer. “Estimation of Subvoxel Fat Infiltration in Neurodegenerative Muscle Disorders Using Quantitative Multi-T2 Analysis.” NMR in Biomedicine 36, no. 9 (2023): e4947. https://doi.org/10.1002/nbm.4947.
Durelle, Clémence, Emilien Delmont, Constance Michel, Amira Trabelsi, Marc-Adrien Hostin, Augustin Ogier, David Bendahan, and Shahram Attarian. “Quantification of Muscle Involvement in Familial Amyloid Polyneuropathy Using MRI.” European Journal of Neurology 30, no. 10 (2023): 3286–95. https://doi.org/10.1111/ene.15970.
Hostin, Marc-Adrien, Augustin C. Ogier, Constance P. Michel, Yann Le Fur, Maxime Guye, Shahram Attarian, Etienne Fortanier, Marc-Emmanuel Bellemare, and David Bendahan. “The Impact of Fatty Infiltration on MRI Segmentation of Lower Limb Muscles in Neuromuscular Diseases: A Comparative Study of Deep Learning Approaches.” Journal of Magnetic Resonance Imaging 58, no. 6 (2023): 1826–35. https://doi.org/10.1002/jmri.28708.
Poullain, François, Pierre Champsaur, Vanessa Pauly, Paul Knoepflin, Thomas Le Corroller, Maud Creze, Martine Pithioux, David Bendahan, and Daphne Guenoun. “Vertebral Trabecular Bone Texture Analysis in Opportunistic MRI and CT Scan Can Distinguish Patients with and without Osteoporotic Vertebral Fracture: A Preliminary Study.” European Journal of Radiology 158 (December 6, 2022): 110642. https://doi.org/10.1016/j.ejrad.2022.110642.
Heskamp, Linda, Augustin Ogier, David Bendahan, and Arend Heerschap. “Whole-Muscle Fat Analysis Identifies Distal Muscle End as Disease Initiation Site in Facioscapulohumeral Muscular Dystrophy.” Communications Medicine 2, no. 1 (December 1, 2022): 155. https://doi.org/10.1038/s43856-022-00217-1.
Knoepflin, Paul, Martine Pithioux, David Bendahan, François Poullain, Thomas Le Corroller, Cyprien Fabre, Vanessa Pauly, et al. “Texture Parameters Measured by UHF-MRI and CT Scan Provide Information on Bone Quality in Addition to BMD: A Biomechanical Ex Vivo Study.” Diagnostics 12, no. 12 (December 2022): 3143. https://doi.org/10.3390/diagnostics12123143.
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Mayoly, Alice, Marie Witters, Elisabeth Jouve, Cécilia Bec, Aurélie Iniesta, Najib Kachouh, Julie Veran, et al. “Intra Articular Injection of Autologous Microfat and Platelets-Rich Plasma in the Treatment of Wrist Osteoarthritis: A Pilot Study.” Journal of Clinical Medicine 11, no. 19 (September 29, 2022): 5786. https://doi.org/10.3390/jcm11195786.
Meimoun, Laura, Émilie Pecchi, Christophe Vilmen, David Bendahan, and Benoît Giannesini. “Effect of Citrulline Malate Supplementation on Muscle Function and Bioenergetics during Short-Term Repeated Bouts of Fatiguing Exercise.” Journal of Sports Sciences 40, no. 17 (September 2, 2022): 1981–90. https://doi.org/10.1080/02640414.2022.2123527.
Katirtzidou, Eirini, Olivier Rager, Arthur Damien Varoquaux, Antoine Poncet, Vincent Lenoir, Nicolas Dulguerov, Alexandra Platon, Valentina Garibotto, Habib Zaidi, and Minerva Becker. “Detection of Distant Metastases and Distant Second Primary Cancers in Head and Neck Squamous Cell Carcinoma: Comparison of [18F]FDG PET/MRI and [18F]FDG PET/CT.” Insights into Imaging 13, no. 1 (July 28, 2022): 121. https://doi.org/10.1186/s13244-022-01261-0.
Amer, Rula, Jannette Nassar, Amira Trabelsi, David Bendahan, Hayit Greenspan, and Noam Ben-Eliezer. “Quantification of Intra-Muscular Adipose Infiltration in Calf/Thigh MRI Using Fully and Weakly Supervised Semantic Segmentation.” Bioengineering 9, no. 7 (July 14, 2022): 315. https://doi.org/10.3390/bioengineering9070315.
Cadour, Farah, Jennifer Cautela, Stanislas Rapacchi, Arthur Varoquaux, Paul Habert, François Arnaud, Alexis Jacquier, et al. “Cardiac MRI Features and Prognostic Value in Immune Checkpoint Inhibitor–Induced Myocarditis.” Radiology 303, no. 3 (June 2022): 512–21. https://doi.org/10.1148/radiol.211765.
Brui, Ekaterina, Anna Mikhailovskaya, Georgiy Solomakha, Alexander Efimtcev, Anna Andreychenko, and Alena Shchelokova. “Volumetric Wireless Coil for Wrist MRI at 1.5 T as a Practical Alternative to Tx/Rx Extremity Coil: A Comparative Study.” Journal of Magnetic Resonance (San Diego, Calif.: 1997) 339 (June 2022): 107209. https://doi.org/10.1016/j.jmr.2022.107209.
Boutray, Marie de, Mélanie Pons, Nicolas Graillon, Cyrille Chossegros, Anthony Reyre, Christophe Chagnaud, and Arthur Varoquaux. “Stensen’s Duct Stenosis Balloon Dilatation: Long-Term Evaluation of Clinical Outcomes and Quality of Life Impacts.” Otolaryngology–Head and Neck Surgery, May 3, 2022, 01945998221097636. https://doi.org/10.1177/01945998221097636.
Shpringer, Guy, David Bendahan, and Noam Ben-Eliezer. “Accelerated Reconstruction of Dictionary-Based T2 Relaxation Maps Based on Dictionary Compression and Gradient Descent Search Algorithms.” Magnetic Resonance Imaging 87 (April 2022): 56–66. https://doi.org/10.1016/j.mri.2021.12.006.
Micieli, Evy, Davide Voci, Nicola Mumoli, Daniela Mastroiacovo, Alexandru Grigorean, Michael Obadia, Nicolas Menjot de Champfleur, et al. “Transient Perivascular Inflammation of the Carotid Artery (TIPIC) Syndrome.” VASA. Zeitschrift Fur Gefasskrankheiten 51, no. 2 (March 2022): 71–77. https://doi.org/10.1024/0301-1526/a000989.
Jourdan, Arthur, Stanislas Rapacchi, Maxime Guye, David Bendahan, Catherine Masson, and Thierry Bège. “Dynamic-MRI Quantification of Abdominal Wall Motion and Deformation during Breathing and Muscular Contraction.” Computer Methods and Programs in Biomedicine 217 (January 29, 2022): 106667. https://doi.org/10.1016/j.cmpb.2022.106667.