Medical Doctor (MD)

Professor (MD, PhD)

at AMU and at AP-HM

MD PhD, Professor in Neurology (CNU 49.01)
Head of the Mutiple Sclerosis Research Team (CRMBM CEMEREM UMRCNRS7339)
Head of the Department of Neurology, Timone University Hospital (APHM)
Medical School of Marseille, Neurosciences (AMU)

Medical Doctor (MD)

Professor (MD, PhD)

Detailed Activities

Jean Pelletier is heading the Department of Neurology of the Timone University Hospital and the research team “multiple sclerosis and CNS demyelinating” diseases of the laboratory CRMBM/CEMEREM.
The activity of the team is focused on MS and CNS demyelinating diseases. We aim at characterizing clinical and functional consequences of MS progression from the very first stage of the disease and along the disease courses, by using innovative in vivo and non-invasive MR parameters and others non invasive approaches (electrophysiology, experimental neuropsychology).
Current Research Interest:
– Morphological, structural, metabolic, functional, clinical, neuropsychological and quality of life status long term follow-up patients at the early stage of MS
– Evaluation of brain plasticity efficiency in cognitive and motor systems of patients with early MS using repetitive transcranial magnetic stimulation (rTMS) and fMRI
– In vivo study of axonal degeneration in MS using brain and spinal cord sodium (23Na) Magnetic Resonance Imaging
– In vivo study of demyelination and remyelination in MS using new MR technics (ie ihMT)
– Application of Ultra High Field (7T) MRI on brain and spinal cord in MS
– New therapeutic approaches in MS (phase1,2,3 clinical trials)


  • Artificial Intelligence
  • Connectivity
  • Dynamic MRI/MRS
  • Image Processing
  • k-space Acquisition
  • Metabolism
  • Microstructure/architecture
  • New Contrasts
  • New MR Biomarkers
  • Parallel Transmit
  • Perfusion Methods
  • Quantitative MRI
  • Quantitative MRS
  • Sodium Homeostatis
  • Ultra-high field MRI
  • X-Nuclei

General Information

Current President of the Scientific Committee of the ARSEP Foundation (French MS Research Foundation)
Current President of the Scientific Committee of the French MS Registry (OFSEP)
Current Director of the South Regional MS Expert Centre (CRCSep Marseille)
Current President of the South Regional MS Network (PACASEP)
Current co-director of the Neurosciences Masters (Aix Marseille University)
Current co-director of the Neurosciences Graduate School (NeuroSchool – Academic Research School dedicated to Neurosciences )
Leader of the MS WP DHUNE Program
Member of the ECTRIMS Executive Committee (2010-2013)

Research Projects

Publications :