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GUYE Maxime

Director of CEMEREM
7T MRI Scientific Director
Professor of Biophysics - MD, PhD
Medicine School, Aix-Marseille University
University Hospital of Marseille (AP-HM)

maxime.guye@ap-hm.fr
tel : +33 4 91 38 84 64

Key Words
- Multimodal MRI and electrophysiology in Epilepsy and Neurodegenerative diseases
- Brain connectivity
- Ultra-high field MRI

Biosketch

Maxime Guye is the director of the medical site (i.e. CEMEREM) of the CRMBM located at the University Hospital of “La Timone” in Marseille. This site hosts 3 MRI systems dedicated to clinical research (i.e. 1.5, 3T and 7T whole body MRI). He is professor of Biophysics at the school of Medicine of Aix-Marseille University. He is consultant in Neurology/Epileptology at the Clinical Neuroscience Department of the University Hospital, APHM. He holds a PhD in Neuroscience and has been trained in MR Physics and Electrophysiology. He has held a research position at the University College of London (Institute of Neurology) after his residency in Neurology in Marseille. He is the current President of the French Society for Magnetic Resonance in Biology and Medicine. He is a member of the Scientific Committee of the French Society of Clinical Neurophysiology. He has been an elected member of the National Committee for Scientific Research (CNRS).

Current Research Interest and projects

  • Human 7T MRI
  • Developing and applying innovative MR methods in neurological and psychiatric diseases in order to improve patient care
  • Studying node interactions in pathological brain networks and their consequences on cognitive networks
  • Combining and comparing multimodal MRI techniques and electrophysiological recordings

Publications

2017

Journal Article

  • JIRSA V. K., PROIX T., PERDIKIS D., WOODMAN M. M., WANG H., GONZALEZ-MARTINEZ J., BERNARD C., BENAR C., GUYE M., CHAUVEL P., BARTOLOMEI F. “The Virtual Epileptic Patient: Individualized whole-brain models of epilepsy spread.”. Neuroimage [En ligne]. 15 January 2017. Vol. 145, p. 377-388. Disponible sur : < http://dx.doi.org/10.1016/j.neuroimage.2016.04.049 > (consulté le no date)
    Résumé : Individual variability has clear effects upon the outcome of therapies and treatment approaches. The customization of healthcare options to the individual patient should accordingly improve treatment results. We propose a novel approach to brain interventions based on personalized brain network models derived from non-invasive structural data of individual patients. Along the example of a patient with bitemporal epilepsy, we show step by step how to develop a Virtual Epileptic Patient (VEP) brain model and integrate patient-specific information such as brain connectivity, epileptogenic zone and MRI lesions. Using high-performance computing, we systematically carry out parameter space explorations, fit and validate the brain model against the patient's empirical stereotactic EEG (SEEG) data and demonstrate how to develop novel personalized strategies towards therapy and intervention. (C) 2016 The Authors. Published by Elsevier Inc.
    Mots-clés : Diffusion MRI, eeg, Functional connectivity, network dynamics, resting brain, snc, spherical-deconvolution, structural connectivity, surgery, temporal-lobe epilepsy, tractography.


  • LEPORQ B., TROTER A. L., FUR Y. L., SALORT-CAMPANA E., GUYE M., BEUF O., ATTARIAN S., BENDAHAN D. “Combined quantification of fatty infiltration, T1-relaxation times and T2*-relaxation times in normal-appearing skeletal muscle of controls and dystrophic patients.”. Magnetic Resonance Materials in Physics, Biology and Medicine [En ligne]. 1 August 2017. Vol. 30, n°4, p. 407-415. Disponible sur : < http://dx.doi.org/10.1007/s10334-017-0616-1 > (consulté le 18 August 2017)
    Résumé : ObjectivesTo evaluate the combination of a fat–water separation method with an automated segmentation algorithm to quantify the intermuscular fatty-infiltrated fraction, the relaxation times, and the microscopic fatty infiltration in the normal-appearing muscle.Materials and methodsMR acquisitions were performed at 1.5T in seven patients with facio-scapulo-humeral dystrophy and eight controls. Disease severity was assessed using commonly used scales for the upper and lower limbs. The fat–water separation method provided proton density fat fraction (PDFF) and relaxation times maps (T2* and T1). The segmentation algorithm distinguished adipose tissue and normal-appearing muscle from the T2* map and combined active contours, a clustering analysis, and a morphological closing process to calculate the index of fatty infiltration (IFI) in the muscle compartment defined as the relative amount of pixels with the ratio between the number of pixels within IMAT and the total number of pixels (IMAT + normal appearing muscle).ResultsIn patients, relaxation times were longer and a larger fatty infiltration has been quantified in the normal-appearing muscle. T2* and PDFF distributions were broader. The relaxation times were correlated to the Vignos scale whereas the microscopic fatty infiltration was linked to the Medwin-Gardner-Walton scale. The IFI was linked to a composite clinical severity scale gathering the whole set of scales.ConclusionThe MRI indices quantified within the normal-appearing muscle could be considered as potential biomarkers of dystrophies and quantitatively illustrate tissue alterations such as inflammation and fatty infiltration.
    Mots-clés : crmbm, Magnetic Resonance Imaging, msk, Muscle dystrophies, Segmentation.


  • MAAROUF A., AUDOIN B., PARIOLLAUD F., GHERIB S., RICO A., SOULIER E., CONFORT-GOUNY S., GUYE M., SCHAD L., PELLETIER J., RANJEVA J. - P., ZAARAOUI W. “Increased total sodium concentration in gray matter better explains cognition than atrophy in MS.”. Neurology [En ligne]. 17 January 2017. Vol. 88, n°3, p. 289-295. Disponible sur : < http://dx.doi.org/10.1212/WNL.0000000000003511 > (consulté le 18 August 2017)
    Résumé : Objective: To investigate whether brain total sodium accumulation assessed by 23Na MRI is associated with cognitive deficit in relapsing-remitting multiple sclerosis (RRMS). Methods: Eighty-nine participants were enrolled in the study (58 patients with RRMS with a disease duration ≤10 years and 31 matched healthy controls). Patients were classified as cognitively impaired if they failed at least 2 tasks on the Brief Repeatable Battery. MRI was performed at 3T using 23Na MRI to obtain total sodium concentration (TSC) in the different brain compartments (lesions, normal-appearing white matter [NAWM], gray matter [GM]) and 1H- magnetization-prepared rapid gradient echo to assess GM atrophy (GM fraction). Results: The mean disease duration was 3.1 years and the median Expanded Disability Status Scale score was 1 (range 0–4.5). Thirty-seven patients were classified as cognitively preserved and 21 as cognitively impaired. TSC was increased in GM and NAWM in cognitively impaired patients compared to cognitively preserved patients and healthy controls. Voxel-wise analysis demonstrated that sodium accumulation was mainly located in the neocortex in cognitively impaired patients. Regression analysis evidenced than the 2 best independent predictors of cognitive impairment were GM TSC and age. Receiver operating characteristic analyses demonstrated that sensitivity and specificity of the GM TSC to classify patients according to their cognitive status were 76% and 71%, respectively. Conclusions: This study provides 2 main findings. (1) In RRMS, total sodium accumulation in the GM is better associated with cognitive impairment than GM atrophy; and (2) total sodium accumulation in patients with cognitive impairment is mainly located in the neocortex.
    Mots-clés : crmbm, snc.

  • PROIX T., BARTOLOMEI F., GUYE M., JIRSA V. K. “Individual brain structure and modelling predict seizure propagation.”. Brain: A Journal of Neurology [En ligne]. 1 March 2017. Vol. 140, n°3, p. 641-654. Disponible sur : < http://dx.doi.org/10.1093/brain/awx004 > (consulté le no date)
    Résumé : See Lytton (doi:10.1093/awx018) for a scientific commentary on this article.Neural network oscillations are a fundamental mechanism for cognition, perception and consciousness. Consequently, perturbations of network activity play an important role in the pathophysiology of brain disorders. When structural information from non-invasive brain imaging is merged with mathematical modelling, then generative brain network models constitute personalized in silico platforms for the exploration of causal mechanisms of brain function and clinical hypothesis testing. We here demonstrate with the example of drug-resistant epilepsy that patient-specific virtual brain models derived from diffusion magnetic resonance imaging have sufficient predictive power to improve diagnosis and surgery outcome. In partial epilepsy, seizures originate in a local network, the so-called epileptogenic zone, before recruiting other close or distant brain regions. We create personalized large-scale brain networks for 15 patients and simulate the individual seizure propagation patterns. Model validation is performed against the presurgical stereotactic electroencephalography data and the standard-of-care clinical evaluation. We demonstrate that the individual brain models account for the patient seizure propagation patterns, explain the variability in postsurgical success, but do not reliably augment with the use of patient-specific connectivity. Our results show that connectome-based brain network models have the capacity to explain changes in the organization of brain activity as observed in some brain disorders, thus opening up avenues towards discovery of novel clinical interventions.
    Mots-clés : brain network models, connectomes, epilepsy, individualized medicine, seizure propagation, snc.

  • RIDLEY B., MARCHI A., WIRSICH J., SOULIER E., CONFORT-GOUNY S., SCHAD L., BARTOLOMEI F., RANJEVA J. - P., GUYE M., ZAARAOUI W. “Brain sodium MRI in human epilepsy: Disturbances of ionic homeostasis reflect the organization of pathological regions.”. NeuroImage [En ligne]. 7 June 2017. Vol. 157, p. 173-183. Disponible sur : < http://dx.doi.org/10.1016/j.neuroimage.2017.06.011 > (consulté le no date)
    Résumé : In light of technical advancements supporting exploration of MR signals other than (1)H, sodium ((23)Na) has received attention as a marker of ionic homeostasis and cell viability. Here, we evaluate for the first time the possibility that (23)Na-MRI is sensitive to pathological processes occurring in human epilepsy. A normative sample of 27 controls was used to normalize regions of interest (ROIs) from 1424 unique brain locales on quantitative (23)Na-MRI and high-resolution (1)H-MPRAGE images. ROIs were based on intracerebral electrodes in ten patients undergoing epileptic network mapping. The stereo-EEG gold standard was used to define regions as belonging to primarily epileptogenic, secondarily irritative and to non-involved regions. Estimates of total sodium concentration (TSC) on (23)Na-MRI and cerebrospinal fluid (CSF) on (1)H imaging were extracted for each patient ROI, and normalized against the same region in controls. ROIs with disproportionate CSF contributions (ZCSF≥1.96) were excluded. TSC levels were found to be elevated in patients relative to controls except in one patient, who suffered non-convulsive seizures during the scan, in whom we found reduced TSC levels. In the remaining patients, an ANOVA (F1100= 12.37, p<0.0001) revealed a highly significant effect of clinically-defined zones (F1100= 11.13, p<0.0001), with higher normalized TSC in the epileptogenic zone relative to both secondarily irritative (F1100= 11, p=0.0009) and non-involved regions (F1100= 17.8, p<0.0001). We provide the first non-invasive, in vivo evidence of a chronic TSC elevation alongside ZCSF levels within the normative range, associated with the epileptogenic region even during the interictal period in human epilepsy, and the possibility of reduced TSC levels due to seizure. In line with modified homeostatic mechanisms in epilepsy - including altered mechanisms underlying ionic gating, clearance and exchange - we provide the first indication of (23)Na-MRI as an assay of altered sodium concentrations occurring in epilepsy associated with the organization of clinically relevant divisions of pathological cortex.
    Mots-clés : Cortical localisation, crmbm, epilepsy, Epilepsy surgery, Intracranial EEG, Ionic imaging, snc, Sodium MRI.

  • RIDLEY B., WIRSICH J., BETTUS G., RODIONOV R., MURTA T., CHAUDHARY U., CARMICHAEL D., THORNTON R., VULLIEMOZ S., MCEVOY A., WENDLING F., BARTOLOMEI F., RANJEVA J. - P., LEMIEUX L., GUYE M. “Simultaneous Intracranial EEG-fMRI Shows Inter-Modality Correlation in Time-Resolved Connectivity Within Normal Areas but Not Within Epileptic Regions.”. Brain Topography [En ligne]. 13 February 2017. Disponible sur : < http://dx.doi.org/10.1007/s10548-017-0551-5 > (consulté le no date)
    Résumé : For the first time in research in humans, we used simultaneous icEEG-fMRI to examine the link between connectivity in haemodynamic signals during the resting-state (rs) and connectivity derived from electrophysiological activity in terms of the inter-modal connectivity correlation (IMCC). We quantified IMCC in nine patients with drug-resistant epilepsy (i) within brain networks in 'healthy' non-involved cortical zones (NIZ) and (ii) within brain networks involved in generating seizures and interictal spikes (IZ1) or solely spikes (IZ2). Functional connectivity (h (2) ) estimates for 10 min of resting-state data were obtained between each pair of electrodes within each clinical zone for both icEEG and fMRI. A sliding window approach allowed us to quantify the variability over time of h (2) (vh (2)) as an indicator of connectivity dynamics. We observe significant positive IMCC for h (2) and vh (2), for multiple bands in the NIZ only, with the strongest effect in the lower icEEG frequencies. Similarly, intra-modal h (2) and vh (2) were found to be differently modified as a function of different epileptic processes: compared to NIZ, [Formula: see text] was higher in IZ1, but lower in IZ2, while [Formula: see text] showed the inverse pattern. This corroborates previous observations of inter-modal connectivity discrepancies in pathological cortices, while providing the first direct invasive and simultaneous comparison in humans. We also studied time-resolved FC variability multimodally for the first time, finding that IZ1 shows both elevated internal [Formula: see text] and less rich dynamical variability, suggesting that its chronic role in epileptogenesis may be linked to greater homogeneity in self-sustaining pathological oscillatory states.
    Mots-clés : connectivity, crmbm, Dynamic connectivity, Focal epilepsy, Multimodal imaging, Resting-state, snc.

  • WEGRZYK J., RANJEVA J. - P., FOURÉ A., KAVOUNOUDIAS A., VILMEN C., MATTEI J. - P., GUYE M., MAFFIULETTI N. A., PLACE N., BENDAHAN D., GONDIN J. “Specific brain activation patterns associated with two neuromuscular electrical stimulation protocols.”. Scientific Reports [En ligne]. 2 June 2017. Vol. 7, n°1, p. 2742. Disponible sur : < http://dx.doi.org/10.1038/s41598-017-03188-9 > (consulté le no date)
    Résumé : The influence of neuromuscular electrical stimulation (NMES) parameters on brain activation has been scarcely investigated. We aimed at comparing two frequently used NMES protocols - designed to vary in the extent of sensory input. Whole-brain functional magnetic resonance imaging was performed in sixteen healthy subjects during wide-pulse high-frequency (WPHF, 100 Hz-1 ms) and conventional (CONV, 25 Hz-0.05 ms) NMES applied over the triceps surae. Each protocol included 20 isometric contractions performed at 10% of maximal force. Voluntary plantar flexions (VOL) were performed as control trial. Mean force was not different among the three protocols, however, total current charge was higher for WPHF than for CONV. All protocols elicited significant activations of the sensorimotor network, cerebellum and thalamus. WPHF resulted in lower deactivation in the secondary somatosensory cortex and precuneus. Bilateral thalami and caudate nuclei were hyperactivated for CONV. The modulation of the NMES parameters resulted in differently activated/deactivated regions related to total current charge of the stimulation but not to mean force. By targeting different cerebral brain regions, the two NMES protocols might allow for individually-designed rehabilitation training in patients who can no longer execute voluntary movements.
    Mots-clés : crmbm, msk.

2016

Journal Article

  • BOUTIÈRE C., REY C., ZAARAOUI W., LE TROTER A., RICO A., CRESPY L., ACHARD S., REUTER F., PARIOLLAUD F., WIRSICH J., ASQUINAZI P., CONFORT-GOUNY S., SOULIER E., GUYE M., PELLETIER J., RANJEVA J. - P., AUDOIN B. “Improvement of spasticity following intermittent theta burst stimulation in multiple sclerosis is associated with modulation of resting-state functional connectivity of the primary motor cortices.”. Multiple Sclerosis (Houndmills, Basingstoke, England) [En ligne]. 1 August 2016. Disponible sur : < http://dx.doi.org/10.1177/1352458516661640 > (consulté le no date)
    Résumé : BACKGROUND: Intermittent theta burst stimulation (iTBS) of the primary motor cortex improves transiently lower limbs spasticity in multiple sclerosis (MS). However, the cerebral mechanisms underlying this effect have never been investigated. OBJECTIVE: To assess whether modulation of spasticity induced by iTBS is underlined by functional reorganization of the primary motor cortices. METHODS: A total of 17 patients with MS suffering from lower limbs spasticity were randomized to receive real iTBS or sham iTBS during the first half of a 5-week indoor rehabilitation programme. Spasticity was assessed using the Modified Ashworth Scale and the Visual Analogue Scale at baseline, after the stimulation session and at the end of the rehabilitation programme. Resting-state functional magnetic resonance imaging (fMRI) was performed at the three time points, and brain functional networks topology was analysed using graph-theoretical approach. RESULTS: At the end of stimulation, improvement of spasticity was greater in real iTBS group than in sham iTBS group (p = 0.026). iTBS had a significant effect on the balance of the connectivity degree between the stimulated and the homologous primary motor cortex (p = 0.005). Changes in inter-hemispheric balance were correlated with improvement of spasticity (rho = 0.56, p = 0.015). CONCLUSION: This longitudinal resting-state fMRI study evidences that functional reorganization of the primary motor cortices may underlie the effect of iTBS on spasticity in MS.
    Mots-clés : connectivity, crmbm, intermittent theta burst stimulation, Multiple Sclerosis, primary motor cortex, resting state fMRI, snc, spasticity.

  • BRICQ S., FRANDON J., BERNARD M., GUYE M., FINAS M., MARCADET L., MIQUEROL L., KOBER F., HABIB G., FAGRET D., JACQUIER A., LALANDE A. “Semiautomatic detection of myocardial contours in order to investigate normal values of the left ventricular trabeculated mass using MRI.”. Journal of magnetic resonance imaging: JMRI [En ligne]. June 2016. Vol. 43, n°6, p. 1398-1406. Disponible sur : < http://dx.doi.org/10.1002/jmri.25113 > (consulté le no date)
    Résumé : PURPOSE: To propose, assess, and validate a semiautomatic method allowing rapid and reproducible measurement of trabeculated and compacted left ventricular (LV) masses from cardiac magnetic resonance imaging (MRI). MATERIALS AND METHODS: We developed a method to automatically detect noncompacted, endocardial, and epicardial contours. Papillary muscles were segmented using semiautomatic thresholding and were included in the compacted mass. Blood was removed from trabeculae using the same threshold tool. Trabeculated, compacted masses and ratio of noncompacted to compacted (NC:C) masses were computed. Preclinical validation was performed on four transgenic mice with hypertrabeculation of the LV (high-resolution cine imaging, 11.75T). Then analysis was performed on normal cine-MRI examinations (steady-state free precession [SSFP] sequences, 1.5T or 3T) obtained from 60 healthy participants (mean age 49 ± 16 years) with 10 men and 10 women for each of the following age groups: [20,39], [40,59], and [60,79]. Interobserver and interexamination segmentation reproducibility was assessed by using Bland-Altman analysis and by computing the correlation coefficient. RESULTS: In normal participants, noncompacted and compacted masses were 6.29 ± 2.03 g/m(2) and 62.17 ± 11.32 g/m(2) , respectively. The NC:C mass ratio was 10.26 ± 3.27%. Correlation between the two observers was from 0.85 for NC:C ratio to 0.99 for end-diastolic volume (P < 10(-5) ). The bias between the two observers was -1.06 ± 1.02 g/m(2) for trabeculated mass, -1.41 ± 2.78 g/m(2) for compacted mass, and -1.51 ± 1.77% for NC:C ratio. CONCLUSION: We propose a semiautomatic method based on region growing, active contours, and thresholding to calculate the NC:C mass ratio. This method is highly reproducible and might help in the diagnosis of LV noncompaction cardiomyopathy. J. Magn. Reson. Imaging 2016;43:1398-1406.
    Mots-clés : cardiovascular magnetic resonance imaging, crmbm, cvs, left ventricle, noncompaction, papillary muscles, trabeculae.

  • DOCHE E., LECOCQ A., MAAROUF A., DUHAMEL G., SOULIER E., CONFORT-GOUNY S., RICO A., GUYE M., AUDOIN B., PELLETIER J., RANJEVA J. - P., ZAARAOUI W. “Hypoperfusion of the thalamus is associated with disability in relapsing remitting multiple sclerosis.”. Journal of Neuroradiology. Journal De Neuroradiologie [En ligne]. 16 November 2016. Disponible sur : < http://dx.doi.org/10.1016/j.neurad.2016.10.001 > (consulté le no date)
    Résumé : BACKGROUND: While gray matter (GM) perfusion abnormalities have been evidenced in multiple sclerosis (MS) patients, the relationships with disability still remain unclear. Considering that atrophy is known to impact on perfusion, we aimed to assess perfusion abnormalities in GM of MS patients, outside atrophic regions and investigate relationships with disability. METHODS: Brain perfusion of 23 relapsing remitting MS patients and 16 matched healthy subjects were assessed at 3T using the pseudo-continuous arterial spin labeling magnetic resonance imaging technique. In order to locate potential GM perfusion abnormalities in regions spared by atrophy, we combined voxelwise comparisons of GM cerebral blood flow (CBF) maps (cortex and deep GM) (P<0.005, FWE-corrected) and voxel-based-morphometry analysis (P<0.005, FDR-corrected) to exclude atrophic regions. Disability was assessed using the Expanded Disability Status Scale (EDSS) and the Multiple Sclerosis Functional Composite score (MSFC). RESULTS: In patients, significant GM hypoperfusion outside atrophic regions was depicted only in bilateral thalami. No other cluster was found to be hypoperfused compared to controls. Perfusion of thalami was correlated to MSFC (P=0.011, rho=0.523). A trend of correlation was found between perfusion of thalami and EDSS (P=0.061, rho=-0.396). CONCLUSION: In relapsing remitting MS, perfusion abnormalities in thalamic regions contribute to disability. These findings suggest that functional impairments of thalami, representing a major brain hub, may disturb various cerebral functions even before structural damage.
    Mots-clés : Atrophy, crmbm, Disability, Multiple Sclerosis, perfusion, Pseudo-continuous arterial spin labeling, snc, Thalamus.

  • DONADIEU M., LE FUR Y., CONFORT-GOUNY S., LE TROTER A., GUYE M., RANJEVA J. - P. “Evidencing different neurochemical profiles between thalamic nuclei using high resolution 2D-PRESS semi-LASER (1)H-MRSI at 7 T.”. Magma (New York, N.Y.) [En ligne]. 8 April 2016. Disponible sur : < http://dx.doi.org/10.1007/s10334-016-0556-1 > (consulté le no date)
    Résumé : OBJECTIVE: To demonstrate that high resolution (1)H semi-LASER MRSI acquired at 7 T permits discrimination of metabolic patterns of different thalamic nuclei. MATERIALS AND METHODS: Thirteen right-handed healthy volunteers were explored at 7 T using a high-resolution 2D-semi-LASER (1)H-MRSI sequence to determine the relative levels of N-Acetyl Aspartate (NAA), choline (Cho) and creatine-phosphocreatine (Cr) in eight VOIs (volume <0.3 ml) centered on four different thalamic nuclei located on the Oxford thalamic connectivity atlas. Post-processing was done using the CSIAPO software. Chemical shift displacement of metabolites was evaluated on a phantom and correction factors were applied to in vivo data. RESULTS: The global assessment (ANOVA p < 0.05) of the neurochemical profiles (NAA, Cho and Cr levels) with thalamic nuclei and hemispheres as factors showed a significant global effect (F = 11.98, p < 0.0001), with significant effect of nucleus type (p < 0.0001) and hemisphere (p < 0.0001). Post hoc analyses showed differences in neurochemical profiles between the left and the right hemisphere (p < 0.05), and differences in neurochemical profiles between nuclei within each hemisphere (p < 0.05). CONCLUSION: For the first time, using high resolution 2D-PRESS semi-LASER (1)H-MRSI acquired at 7 T, we demonstrated that the neurochemical profiles were different between thalamic nuclei, and that these profiles were dependent on the brain hemisphere.
    Mots-clés : 1H-MRSI, Connectivity atlas, crmbm, Neurochemical profiles, snc, Thalamic nuclei, Ultra high field.

  • DONADIEU M., LE FUR Y., LECOCQ A., MAUDSLEY A. A., GHERIB S., SOULIER E., CONFORT-GOUNY S., PARIOLLAUD F., RANJEVA M. - P., PELLETIER J., GUYE M., ZAARAOUI W., AUDOIN B., RANJEVA J. - P. “Metabolic voxel-based analysis of the complete human brain using fast 3D-MRSI: Proof of concept in multiple sclerosis.”. Journal of magnetic resonance imaging: JMRI [En ligne]. August 2016. Vol. 44, n°2, p. 411-419. Disponible sur : < http://dx.doi.org/10.1002/jmri.25139 > (consulté le no date)
    Résumé : PURPOSE: To detect local metabolic abnormalities over the complete human brain in multiple sclerosis (MS) patients, we used optimized fast volumic echo planar spectroscopic imaging (3D-EPSI). MATERIALS AND METHODS: Weighted mean combination of two 3D-EPSI covering the whole brain acquired at 3T in AC-PC and AC-PC+15° axial planes was performed to obtain high-quality metabolite maps for five metabolites: N-acetyl aspartate (NAA), glutamate+glutamine (Glx), choline (Cho), myo-inositol (m-Ins), and creatine+phosphocreatine (tCr). After spatial normalization, maps from 19 patients suffering from relapsing-remitting MS were compared to 19 matched controls using statistical mapping analyses to determine the topography of metabolic abnormalities. Probabilistic white matter (WM) T2 lesion maps and gray matter (GM) atrophy maps were also generated. RESULTS: Two-group analysis of variance (ANOVA) (SPM8, P < 0.005, false discovery rate [FDR]-corrected P < 0.05 at the cluster level with age and sex as confounding covariates) comparing patients and controls matched for age and sex showed clusters of abnormal metabolite levels with 1) decreased NAA (around -15%) and Glx (around 20%) predominantly in GM within prefrontal cortices, motor cortices, bilateral thalami, and mesial temporal cortices in line with neuronal/neuro-astrocytic dysfunction; 2) increased m-Ins (around + 20%) inside WM T2 lesions and in the normal-appearing WM of temporal-occipital lobes, suggesting glial activation. CONCLUSION: We demonstrate the ability to noninvasively map over the complete brain-from vertex to cerebellum-with a validated sequence, the metabolic abnormalities associated with MS, for characterizing the topography of pathological processes affecting widespread areas of WM and GM and its functional impact. J. Magn. Reson. Imaging 2016;44:411-419.
    Mots-clés : crmbm, Inflammation, Multiple Sclerosis, neurodegeneration, proton magnetic resonance spectroscopic imaging, snc, statistical mapping analysis, whole brain.

  • FAIVRE A., ROBINET E., GUYE M., ROUSSEAU C., MAAROUF A., LE TROTER A., ZAARAOUI W., RICO A., CRESPY L., SOULIER E., CONFORT-GOUNY S., PELLETIER J., ACHARD S., RANJEVA J. - P., AUDOIN B. “Depletion of brain functional connectivity enhancement leads to disability progression in multiple sclerosis: A longitudinal resting-state fMRI study.”. Multiple Sclerosis (Houndmills, Basingstoke, England) [En ligne]. November 2016. Vol. 22, n°13, p. 1695-1708. Disponible sur : < http://dx.doi.org/10.1177/1352458516628657 > (consulté le no date)
    Résumé : BACKGROUND: The compensatory effect of brain functional connectivity enhancement in relapsing-remitting multiple sclerosis (RRMS) remains controversial. OBJECTIVE: To characterize the relationships between brain functional connectivity changes and disability progression in RRMS. METHODS: Long-range connectivity, short-range connectivity, and density of connections were assessed using graph theoretical analysis of resting-state functional magnetic resonance imaging (fMRI) data acquired in 38 RRMS patients (disease duration: 120 ± 32 months) and 24 controls. All subjects were explored at baseline and all patients and six controls 2 years later. RESULTS: At baseline, levels of long-range and short-range brain functional connectivity were higher in patients compared to controls. During the follow-up, decrease in connections' density was inversely correlated with disability progression. Post-hoc analysis evidenced differential evolution of brain functional connectivity metrics in patients according to their level of disability at baseline: while patients with lowest disability at baseline experienced an increase in all connectivity metrics during the follow-up, patients with higher disability at baseline showed a decrease in the connectivity metrics. In these patients, decrease in the connectivity metrics was associated with disability progression. CONCLUSION: The study provides two main findings: (1) brain functional connectivity enhancement decreases during the disease course after reaching a maximal level, and (2) decrease in brain functional connectivity enhancement participates in disability progression.
    Mots-clés : crmbm, cvs, Disability, Functional connectivity, Functional MRI, graph theory, Multiple Sclerosis.

  • FOURé A., NOSAKA K., GASTALDI M., MATTEI J. - P., BOUDINET H., GUYE M., VILMEN C., LE FUR Y., BENDAHAN D., GONDIN J. “Effects of branched-chain amino acids supplementation on both plasma amino acids concentration and muscle energetics changes resulting from muscle damage: A randomized placebo controlled trial.”. Clinical Nutrition (Edinburgh, Scotland) [En ligne]. February 2016. Vol. 35, n°1, p. 83-94. Disponible sur : < http://dx.doi.org/10.1016/j.clnu.2015.03.014 > (consulté le no date)
    Résumé : BACKGROUND & AIMS: Branched-chain amino acids promote muscle-protein synthesis, reduce protein oxidation and have positive effects on mitochondrial biogenesis and reactive oxygen species scavenging. The purpose of the study was to determine the potential benefits of branched-chain amino acids supplementation on changes in force capacities, plasma amino acids concentration and muscle metabolic alterations after exercise-induced muscle damage. METHODS: (31)P magnetic resonance spectroscopy and biochemical analyses were used to follow the changes after such damage. Twenty six young healthy men were randomly assigned to supplemented branched-chain amino acids or placebo group. Knee extensors maximal voluntary isometric force was assessed before and on four days following exercise-induced muscle damage. Concentrations in phosphocreatine [PCr], inorganic phosphate [Pi] and pH were measured during a standardized rest-exercise-recovery protocol before, two (D2) and four (D4) days after exercise-induced muscle damage. RESULTS: No significant difference between groups was found for changes in maximal voluntary isometric force (-24% at D2 and -21% at D4). Plasma alanine concentration significantly increased immediately after exercise-induced muscle damage (+25%) in both groups while concentrations in glycine, histidine, phenylalanine and tyrosine decreased. No difference between groups was found in the increased resting [Pi] (+42% at D2 and +34% at D4), decreased resting pH (-0.04 at D2 and -0.03 at D4) and the slower PCr recovery rate (-18% at D2 and -24% at D4). CONCLUSIONS: The damaged muscle was not able to get benefits out of the increased plasma branched-chain amino acids availability to attenuate changes in indirect markers of muscle damage and muscle metabolic alterations following exercise-induced muscle damage.
    Mots-clés : crmbm, Double blind randomized placebo controlled trial, Exercise induced-muscle damage, Magnetic Resonance Spectroscopy, msk.

  • LE TROTER A., FOURÉ A., GUYE M., CONFORT-GOUNY S., MATTEI J. - P., GONDIN J., SALORT-CAMPANA E., BENDAHAN D. “Volume measurements of individual muscles in human quadriceps femoris using atlas-based segmentation approaches.”. Magma (New York, N.Y.) [En ligne]. April 2016. Vol. 29, n°2, p. 245-257. Disponible sur : < http://dx.doi.org/10.1007/s10334-016-0535-6 > (consulté le no date)
    Résumé : OBJECTIVES: Atlas-based segmentation is a powerful method for automatic structural segmentation of several sub-structures in many organs. However, such an approach has been very scarcely used in the context of muscle segmentation, and so far no study has assessed such a method for the automatic delineation of individual muscles of the quadriceps femoris (QF). In the present study, we have evaluated a fully automated multi-atlas method and a semi-automated single-atlas method for the segmentation and volume quantification of the four muscles of the QF and for the QF as a whole. SUBJECTS AND METHODS: The study was conducted in 32 young healthy males, using high-resolution magnetic resonance images (MRI) of the thigh. The multi-atlas-based segmentation method was conducted in 25 subjects. Different non-linear registration approaches based on free-form deformable (FFD) and symmetric diffeomorphic normalization algorithms (SyN) were assessed. Optimal parameters of two fusion methods, i.e., STAPLE and STEPS, were determined on the basis of the highest Dice similarity index (DSI) considering manual segmentation (MSeg) as the ground truth. Validation and reproducibility of this pipeline were determined using another MRI dataset recorded in seven healthy male subjects on the basis of additional metrics such as the muscle volume similarity values, intraclass coefficient, and coefficient of variation. Both non-linear registration methods (FFD and SyN) were also evaluated as part of a single-atlas strategy in order to assess longitudinal muscle volume measurements. The multi- and the single-atlas approaches were compared for the segmentation and the volume quantification of the four muscles of the QF and for the QF as a whole. RESULTS: Considering each muscle of the QF, the DSI of the multi-atlas-based approach was high 0.87 ± 0.11 and the best results were obtained with the combination of two deformation fields resulting from the SyN registration method and the STEPS fusion algorithm. The optimal variables for FFD and SyN registration methods were four templates and a kernel standard deviation ranging between 5 and 8. The segmentation process using a single-atlas-based method was more robust with DSI values higher than 0.9. From the vantage of muscle volume measurements, the multi-atlas-based strategy provided acceptable results regarding the QF muscle as a whole but highly variable results regarding individual muscle. On the contrary, the performance of the single-atlas-based pipeline for individual muscles was highly comparable to the MSeg, thereby indicating that this method would be adequate for longitudinal tracking of muscle volume changes in healthy subjects. CONCLUSION: In the present study, we demonstrated that both multi-atlas and single-atlas approaches were relevant for the segmentation of individual muscles of the QF in healthy subjects. Considering muscle volume measurements, the single-atlas method provided promising perspectives regarding longitudinal quantification of individual muscle volumes.
    Mots-clés : crmbm, Fusion, Individual muscle volume measurements, MRI, msk, Multi-atlas-based segmentation, Non-linear registration, Quadriceps femoris muscle.

  • MARSOT A., BOUCHERIE Q., KHELOUFI F., RIFF C., BRAUNSTEIN D., DUPOUEY J., GUILHAUMOU R., ZENDJIDJIAN X., BONIN-GUILLAUME S., FAKRA E., GUYE M., JIRSA V., AZORIN J. - M., BELZEAUX R., ADIDA M., MICALLEF J., BLIN O. “[What can we expect from clinical trials in psychiatry?].”. L'Encephale [En ligne]. December 2016. Vol. 42, n°6S, p. S2-S6. Disponible sur : < http://dx.doi.org/10.1016/S0013-7006(17)30046-5 > (consulté le no date)
    Résumé : Clinical trials in psychiatry allow to build the regulatory dossiers for market authorization but also to document the mechanism of action of new drugs, to build pharmacodynamics models, evaluate the treatment effects, propose prognosis, efficacy or tolerability biomarkers and altogether to assess the impact of drugs for patient, caregiver and society. However, clinical trials have shown some limitations. Number of recent dossiers failed to convince the regulators. The clinical and biological heterogeneity of psychiatric disorders, the pharmacokinetic and pharmacodynamics properties of the compounds, the lack of translatable biomarkers possibly explain these difficulties. Several breakthrough options are now available: quantitative system pharmacology analysis of drug effects variability, pharmacometry and pharmacoepidemiology, Big Data analysis, brain modelling. In addition to more classical approaches, these opportunities lead to a paradigm change for clinical trials in psychiatry.
    Mots-clés : Cerveau virtuel, Clinical trials, Essais cliniques, Pharmacoépidémiologie, Pharmacoepidemiology, Pharmacogenetics, Pharmacogenétique, Pharmacologie quantitative des systèmes, Quantitative system pharmacologie, snc, Virtual brain.

  • MARTIN A., GROSPRÊTRE S., VILMEN C., GUYE M., MATTEI J. - P., LE FUR Y., BENDAHAN D., GONDIN J. “The Etiology of Muscle Fatigue Differs between Two Electrical Stimulation Protocols.”. Medicine and Science in Sports and Exercise [En ligne]. August 2016. Vol. 48, n°8, p. 1474-1484. Disponible sur : < http://dx.doi.org/10.1249/MSS.0000000000000930 > (consulté le no date)
    Résumé : PURPOSE: This study aimed at investigating the mechanisms involved in the force reduction induced by two electrical stimulation (ES) protocols that were designed to activate motor units differently. METHODS: The triceps surae of 11 healthy subjects (8 men; age, ~28 yr) was activated using ES applied over the tibial nerve. Two ES protocols (conventional [CONV]: 20 Hz, 0.05 ms vs wide-pulse high-frequency [WPHF]: 80 Hz, 1 ms) were performed and involved 40 trains (6 s on-6 s off) delivered at an intensity (IES) evoking 20% of maximal voluntary contraction. To analyze the mechanical properties of the motor units activated at IES, force-frequency relation was evoked before and after each protocol. H-reflex and M-wave responses evoked by the last stimulation pulse were also assessed during each ES protocol. Electromyographic responses (∑EMG) were recorded after each train to analyze the behavior of the motor units activated at IES. Metabolic variables, including relative concentrations of phosphocreatine and inorganic phosphate as well as intracellular pH, were assessed using P-MR spectroscopy during each protocol. RESULTS: Larger H-reflex amplitudes were observed during WPHF as compared with CONV, whereas opposite findings were observed for M-wave amplitudes. Despite this difference, both the force reduction (-26%) and metabolic changes were similar between the two protocols. The CONV protocol induced a rightward shift of the force-frequency relation, whereas a significant reduction of the ∑EMG evoked at IES was observed only for the WPHF. CONCLUSIONS: These results suggest that a decreased number of active motor units mainly contributed to WPHF-induced force decrease, whereas intracellular processes were most likely involved in the force reduction occurring during CONV stimulation.
    Mots-clés : crmbm, msk.

  • MASSIRE A., TASO M., BESSON P., GUYE M., RANJEVA J. - P., CALLOT V. “High-resolution multi-parametric quantitative magnetic resonance imaging of the human cervical spinal cord at 7T.”. NeuroImage [En ligne]. 26 August 2016. Vol. 143, p. 58-69. Disponible sur : < http://dx.doi.org/10.1016/j.neuroimage.2016.08.055 > (consulté le no date)
    Résumé : Quantitative MRI techniques have the potential to characterize spinal cord tissue impairments occurring in various pathologies, from both microstructural and functional perspectives. By enabling very high image resolution and enhanced tissue contrast, ultra-high field imaging may offer further opportunities for such characterization. In this study, a multi-parametric high-resolution quantitative MRI protocol is proposed to characterize in vivo the human cervical spinal cord at 7T. Multi-parametric quantitative MRI acquizitions including T1, T2(*) relaxometry mapping and axial diffusion MRI were performed on ten healthy volunteers with a whole-body 7T system using a commercial prototype coil-array dedicated to cervical spinal cord imaging. Automatic cord segmentation and multi-parametric data registration to spinal cord templates enabled robust regional studies within atlas-based WM tracts and GM horns at the C3 cervical level. T1 value, cross-sectional area and GM/WM ratio evolutions along the cervical cord were also reported. An original correction method for B1(+)-biased T1 mapping sequence was additionally proposed and validated on phantom. As a result, relaxometry and diffusion parameters derived from high-resolution quantitative MRI acquizitions were reported at 7T for the first time. Obtained images, with unmatched resolutions compared to lower field investigations, provided exquisite anatomical details and clear delineation of the spinal cord substructures within an acquisition time of 30min, compatible with clinical investigations. Regional statistically significant differences were highlighted between WM and GM based on T1 and T2* maps (p<10(-3)), as well as between sensory and motor tracts based on diffusion tensor imaging maps (p<0.05). The proposed protocol demonstrates that ultra-high field spinal cord high-resolution quantitative MRI is feasible and lays the groundwork for future clinical investigations of degenerative spinal cord pathologies.
    Mots-clés : crmbm, diffusion tensor imaging, Quantitative MRI, Relaxometry mapping, snc, Spinal Cord, Template-based segmentation, Ultra-high field.

  • RIDLEY B., BELTRAMONE M., WIRSICH J., LE TROTER A., TRAMONI E., AUBERT S., ACHARD S., RANJEVA J. - P., GUYE M., FELICIAN O. “Alien Hand, Restless Brain: Salience Network and Interhemispheric Connectivity Disruption Parallel Emergence and Extinction of Diagonistic Dyspraxia.”. Frontiers in Human Neuroscience [En ligne]. 2016. Vol. 10, p. 307. Disponible sur : < http://dx.doi.org/10.3389/fnhum.2016.00307 > (consulté le no date)
    Résumé : Diagonistic dyspraxia (DD) is by far the most spectacular manifestation reported by sufferers of acute corpus callosum (CC) injury (so-called "split-brain"). In this form of alien hand syndrome, one hand acts at cross purposes with the other "against the patient's will". Although recent models view DD as a disorder of motor control, there is still little information regarding its neural underpinnings, due to widespread connectivity changes produced by CC insult, and the obstacle that non-volitional movements represent for task-based functional neuroimaging studies. Here, we studied patient AM, the first report of DD in patient with complete developmental CC agenesis. This unique case also offers the opportunity to study the resting-state connectomics of DD in the absence of diffuse changes subsequent to CC injury or surgery. AM developed DD following status epilepticus (SE) which resolved over a 2-year period. Whole brain functional connectivity (FC) was compared (Crawford-Howell [CH]) to 16 controls during the period of acute DD symptoms (Time 1) and after remission (Time 2). Whole brain graph theoretical models were also constructed and topological efficiency examined. At Time 1, disrupted FC was observed in inter-hemispheric and intra-hemispheric right edges, involving frontal superior and midline structures. Graph analysis indicated disruption of the efficiency of salience and right frontoparietal (FP) networks. At Time 2, after remission of diagnostic dyspraxia symptoms, FC and salience network changes had resolved. In sum, longitudinal analysis of connectivity in AM indicates that DD behaviors could result from disruption of systems that support the experience and control of volitional movements and the ability to generate appropriate behavioral responses to salient stimuli. This also raises the possibility that changes to large-scale functional architecture revealed by resting-state functional magnetic resonance imaging (fMRI) (rs-fMRI) may provide relevant information on the evolution of behavioral syndromes in addition to that provided by structural and task-based functional imaging.
    Mots-clés : alien hand, callosal agenesis, crmbm, disconnection syndrome, epilepsy, Functional connectivity, graph theory, Resting-state, snc.

  • TASO M., GIRARD O. M., DUHAMEL G., LE TROTER A., FEIWEIER T., GUYE M., RANJEVA J. - P., CALLOT V. “Tract-specific and age-related variations of the spinal cord microstructure: a multi-parametric MRI study using diffusion tensor imaging (DTI) and inhomogeneous magnetization transfer (ihMT).”. NMR in biomedicine [En ligne]. June 2016. Vol. 29, n°6, p. 817-832. Disponible sur : < http://dx.doi.org/10.1002/nbm.3530 > (consulté le no date)
    Résumé : Being able to finely characterize the spinal cord (SC) microstructure and its alterations is a key point when investigating neural damage mechanisms encountered in different central nervous system (CNS) pathologies, such as multiple sclerosis, amyotrophic lateral sclerosis or myelopathy. Based on novel methods, including inhomogeneous magnetization transfer (ihMT) and dedicated SC probabilistic atlas post-processing, the present study focuses on the in vivo characterization of the healthy SC tissue in terms of regional microstructure differences between (i) upper and lower cervical vertebral levels and (ii) sensory and motor tracts, as well as differences attributed to normal aging. Forty-eight healthy volunteers aged from 20 to 70 years old were included in the study and scanned at 3 T using axial high-resolution T2 *-w imaging, diffusion tensor imaging (DTI) and ihMT, at two vertebral levels (C2 and C5). A processing pipeline with minimal user intervention, SC segmentation and spatial normalization into a reference space was implemented in order to assess quantitative morphological and structural parameters (cross-sectional areas, scalar DTI and MT/ihMT metrics) in specific white and gray matter regions of interest. The multi-parametric MRI metrics collected allowed upper and lower cervical levels to be distinguished, with higher ihMT ratio (ihMTR), higher axial diffusivity (λ∥ ) and lower radial diffusivity (λ⊥ ) at C2 compared with C5. Significant differences were also observed between white matter fascicles, with higher ihMTR and lower λ∥ in motor tracts compared with posterior sensory tracts. Finally, aging was found to be associated with significant metric alterations (decreased ihMTR and λ∥ ). The methodology proposed here, which can be easily transferred to the clinic, provides new insights for SC characterization. It bears great potential to study focal and diffuse SC damage in neurodegenerative and demyelinating diseases. Copyright © 2016 John Wiley & Sons, Ltd.
    Mots-clés : Aging, crmbm, diffusion tensor imaging (DTI), ihMT, inhomogeneous magnetization transfer (ihMT), microstructure, multi-parametric MRI, snc, Spinal Cord.


  • WIRSICH J., PERRY A., RIDLEY B., PROIX T., GOLOS M., BÉNAR C., RANJEVA J. - P., BARTOLOMEI F., BREAKSPEAR M., JIRSA V., GUYE M. “Whole-brain analytic measures of network communication reveal increased structure-function correlation in right temporal lobe epilepsy.”. NeuroImage: Clinical [En ligne]. 2016. Vol. 11, p. 707-718. Disponible sur : < http://dx.doi.org/10.1016/j.nicl.2016.05.010 > (consulté le 7 June 2016)
    Résumé : The in vivo structure-function relationship is key to understanding brain network reorganization due to pathologies. This relationship is likely to be particularly complex in brain network diseases such as temporal lobe epilepsy, in which disturbed large-scale systems are involved in both transient electrical events and long-lasting functional and structural impairments. Herein, we estimated this relationship by analyzing the correlation between structural connectivity and functional connectivity in terms of analytical network communication parameters. As such, we targeted the gradual topological structure-function reorganization caused by the pathology not only at the whole brain scale but also both in core and peripheral regions of the brain. We acquired diffusion (dMRI) and resting-state fMRI (rsfMRI) data in seven right-lateralized TLE (rTLE) patients and fourteen healthy controls and analyzed the structure-function relationship by using analytical network communication metrics derived from the structural connectome. In rTLE patients, we found a widespread hypercorrelated functional network. Network communication analysis revealed greater unspecific branching of the shortest path (search information) in the structural connectome and a higher global correlation between the structural and functional connectivity for the patient group. We also found evidence for a preserved structural rich-club in the patient group. In sum, global augmentation of structure-function correlation might be linked to a smaller functional repertoire in rTLE patients, while sparing the central core of the brain which may represent a pathway that facilitates the spread of seizures.
    Mots-clés : crmbm, Functional connectivity, Network based statistics, Network communication, rich club, snc, structural connectivity, Temporal lobe epilepsy.

2015

Journal Article

  • FAGET-AGIUS C., CATHERINE F. - A., BOYER L., WIRSICH J., JONATHAN W., RANJEVA J. - P., JEAN-PHILIPPE R., RICHIERI R., RAPHAELLE R., SOULIER E., ELISABETH S., CONFORT-GOUNY S., SYLVIANE C. - G., AUQUIER P., PASCAL A., GUYE M., MAXIME G., LANÇON C., CHRISTOPHE L. “Neural substrate of quality of life in patients with schizophrenia: a magnetisation transfer imaging study.”. Scientific Reports [En ligne]. 3 December 2015. Vol. 5, p. 17650. Disponible sur : < http://dx.doi.org/10.1038/srep17650 > (consulté le no date)
    Résumé : The aim of this study was to investigate the neural substrate underlying quality of life (QoL) and to demonstrate the microstructural abnormalities associated with impaired QoL in a large sample of patients with schizophrenia, using magnetisation transfer imaging. A total of 81 right-handed men with a diagnosis of schizophrenia and 25 age- and sex-similar healthy controls were included and underwent a 3T MRI with magnetization transfer ratio (MTR) to detect microstructural abnormalities. Compared with healthy controls, patients with schizophrenia had grey matter (GM) decreased MTR values in the temporal lobe (BA21, BA37 and BA38), the bilateral insula, the occipital lobe (BA17, BA18 and BA19) and the cerebellum. Patients with impaired QoL had lower GM MTR values relative to patients with preserved QoL in the bilateral temporal pole (BA38), the bilateral insula, the secondary visual cortex (BA18), the vermis and the cerebellum. Significant correlations between MTR values and QoL scores (p < 0.005) were observed in the GM of patients in the right temporal pole (BA38), the bilateral insula, the vermis and the right cerebellum. Our study shows that QoL impairment in patients with schizophrenia is related to the microstructural changes in an extensive network, suggesting that QoL is a bio-psychosocial marker.
    Mots-clés : Adolescent, Adult, Brain, Cerebral Cortex, crmbm, Gray matter, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Neurons, Quality of Life, Radiography, Schizophrenia, snc, Surveys and Questionnaires, Temporal Lobe.

  • FOURÉ A., LE TROTER A., GUYE M., MATTEI J. - P., BENDAHAN D., GONDIN J. “Localization and quantification of intramuscular damage using statistical parametric mapping and skeletal muscle parcellation.”. Scientific Reports [En ligne]. 2015. Vol. 5, p. 18580. Disponible sur : < http://dx.doi.org/10.1038/srep18580 > (consulté le no date)
    Résumé : In the present study, we proposed an original and robust methodology which combines the spatial normalization of skeletal muscle images, the statistical parametric mapping (SPM) analysis and the use of a specific parcellation in order to accurately localize and quantify the extent of skeletal muscle damage within the four heads of the quadriceps femoris. T2 maps of thigh muscles were characterized before, two (D2) and four (D4) days after 40 maximal isometric electrically-evoked contractions in 25 healthy young males. On the basis of SPM analysis of coregistrated T2 maps, the alterations were similarly detected at D2 and D4 in the superficial and distal regions of the vastus medialis (VM) whereas the proportion of altered muscle was higher in deep muscle regions of the vastus lateralis at D4 (deep: 35 ± 25%, superficial: 23 ± 15%) as compared to D2 (deep: 18 ± 13%, superficial: 17 ± 13%). The present methodology used for the first time on skeletal muscle would be of utmost interest to detect subtle intramuscular alterations not only for the diagnosis of muscular diseases but also for assessing the efficacy of potential therapeutic interventions and clinical treatment strategies.
    Mots-clés : crmbm, msk.

  • LECOCQ A., LE FUR Y., AMADON A., VIGNAUD A., COZZONE P. J., GUYE M., RANJEVA J. - P. “Fast water concentration mapping d to normize (Gimages-Rectacucienopinteing. A . SciMagma (New Y, sugN.Y.)pan> [En ligne]. 201Febru vis5. Vol. 5, 28°6, p. 70787-7%2Disponible sur : < http://dx.doi.org/10.1002/n7/334-014-0451-6" t(consulté le no date)
    Résumé : In OBJECT: Tooposed a ascictd robust metuisition tim peri-processing, tpeline witt QoLof e on-patible with clinical invortloions nottbsert analotocoleep ns (λρay pped forasreference spa asshodabolmappinrmalization ofhis also l thaer-hemtlej sub intra-hemup. Impared is of thenetic resonance imactacucienopinteing. A (MRSdata in long-ladinal analowing- Im such. Asur :ej sus. MATERIALS AND METHMots-clés : crmbm, msk.

  • LECOCQ A., LE FUR Y., AMAMAUDS B.,A., LE TROTER A., GUYSINE FF, SYLVABATI, DUHAONADIEU, DUHFORT-GOUNY S., SYLZONE P. J., GUYE M., RANJEVA J. - P. “Fasle-brain anantitative morping andthenodabolmmasing stattest echo tf="e-dim ns l contocoleeMRSd . Scirnal Artthenetic resonance imaeing. A: JMRIpan> [En ligne]. 201Aug met5. Vol. 5, 42°6, 2. 707280-289Disponible sur : < http://dx.doi.org/10.1002/nbmjmri.24809(consulté le no date)
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Résumé : In BACKGRY SD: Tooimvideee extent of s a 2ch comle brain scantitative mortf="e-dim ns l con(3D)enetic resonance imactacucienopinteing. A (MRSdatpins nbe easerned ima clieasu to chaortloiiain scanodabolmsm a larpopr dn oftthelthy volunteers ag. METHMots-clés : crmbm, msk.

  • LECMAARY F, FEIWER A.,- P. CHRZAARAOUI, RANTROTER A., GUYBANN E., ELIBY A.,IGUYE M., RANP E.OT, WIRBARIT V. CPERRYLLET E., GUYTOURBAH, GUYEDAN, AUQUI">SciMiple sclSrosis or (Hd:urmil patBag mastokeUYEng:nnd)pan> [En ligne]. 2019 Octo 2015. Volponible sur : < http://dx.doi.org/10.100217F/1352458515607649(consulté le no date)
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  • Résumé : In BACKGRY SD: Machic s/zoe invoral t correralns andintraflam=bi tracessingwera ltiple sclerosis, amyclos locaed to a smxl miclosf, BA1nbe now parerved in theo strng magultio-ller perficametretic resirof txsprl(USPIO). the present stu1-rs ong-ladinal anady, we proaimto chaect red. r presenue=e was the useairmct nov ue in tejurytthenechic s/ztrafiltion mappatients witer 40 first timnical invov of sketiple sclerosis, a. METHMots-clés : crmbical inlytiutid witdrome, ermbm, Granechic s/z,I, sncMiple sclSrosis ornc, SurUSPIOdiv>

  • LECLEY B., P G., AMAROUSSEAU CPERSICH J., JONTROTER A., GUYSIER E., ELIFORT-GOUNY S., SYLTOLOMEI F., BREJEVA J. - P., JEAACHARD, SYLE M. “WhoNodand ppromenrealed scferencesl to airmct nf eralized TLEfrcmiclepsy.< assDOIhuborganization ca. NeuroImage: Cpan> [En ligne]. 201Septer 2015. Vol. 5, 118. 70739-4 Disponible sur : < http://dx.doi.org/10.1016/j.niclons,ges/z.5. Vo010 9t(consulté le no date)
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  • Résumé : In Tuseairmct nfe dialtmlayeas p ff suoy theairment in pats">atf thework diseases shoss onlfunlyterstandooAt Tmostat as s">atf,Efrcmiclepsy.< assacharacterized by therecurr straures. bi tracarmc, T ween strlepsy.< assasdiaction cornfe diaeralizedof Lifuures.s inoing-stuish ween strup. IsurFurrapem, twotiple sclrics dericatc the matelepsy.< assh theaerencesllocaralized TLElepsy.gmapwork disgadifhiymric elethe GMde burtifgmetftional conin whiwork dis;th impa:20 lepsy.
    Mots-clés : crmbm, msklepsy, in ctional connectivity, Netphic s st tNetHtmlayeasmapoiymric Network bass">atl. A, Ring-state fMsk.

  • LECTASO, RANTROTER A., GUYSDIKA, DUHFOHEN-ADAD, JONARNOUX “-, GUYE M., RANJEVA J. - P. ATHET V. VWhoAnatiio wittial nolytwrmize (GdstlatesSciroImage: Cpan> [En ligne]. 20115nAug met5. Vol. 5, 1 BA170720-28Disponible sur : < http://dx.doi.org/10.1016/j.niclons,ges/z.5. Vo010 34(consulté le no date)
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  • Résumé : In Recesllo,diaT2*-e t="1Gdstlates-oalscessids o the inar dn magDICEfilar hedof reicacyce/tetween MTRs, uaugmskeo/zoed thiWM/GMfquekHet C m, phtical strferences werween strng mal funillyingrlthy volunteers agp as p ss qu A ng magthampleege;"nk.pearactal normalization of ske superej sus'I wita smamunionftlates
    Mots-clés : crmbm, msk.

  • LECVAROQUAUX, LE FUR Y., AMAIMPERIALE, LE REYRE, LE MONTAVA, DUHFAKHRY NDUHNAMER I-, GUYMIER N, AUQPACAK KGUYE M., RANTAïEB DWhoMetic resonance imactacucienopf potearag sAsramas:iwow /aut="1s ilogrtheo strhodabolcs os . SciNotopt>">-Re dne hCe imrpan> [En ligne]. 201Aug met5. Vol. 5, 22°6, 4A1707M1-8Disponible sur : < http://dx.doi.org/10.1016530/ERC-15-024t(consulté le no date)
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  • Résumé : In Parag sAsramas (PGLs) nbe easociated with impmutons nottheeeneosnfe diacallyr" nylmapociit(TCA) ny.png S acs onbsdehydrleens sh(SDHx)pmutons notacha prese on exaex iosnfeeenetl inlytect red. y TCA ny.pntecf susrh a diratmr dn oftthes acs onbg S acs onb,2ch comasusrhigmfgmecohodabolmma, nbe easected at theexeo strhodabolcs osd ppromen HetTuseaim a ss study focwposbe nue=ua te perintial to r brapoteocoleeketic resonance ima(MR)actacucienopf (mage-MRS)r sucitifiero theSDHx-re dne hPGLsrtheo str skenan mcri mo a. Et temients andprrroposctacu mo a nue=ua theh a dh. Asurvoxel mage-MRS.s-Rectacucn m theht="1 tumsesr(r (D4SDHx-re dne hPGLs,mpwoatioradresPGLs,m hanimrvl invdchwannama,s ske hanimrvl invlons,fib thaere obsuisitrima clira-heprene hlifieive mo aompared to D2 orape tumseswoais acs onbsonance imat 0kcwposected at y fortheSDHx-re dne htumsemients ang Stacucn lifieiocwpossultsprre hgoon the Gre/ nbses,shodium the wo nbses,spoor the wo nbses,s cliv-aa-hepreno witthe GM ler, Hfnbseg Sler les ds nothadter GM stacucn lifieiocpared to D2 largles ds no. Jugr disPGLsro fororhibine higpoorGM stacucn lifieiocpared to D2 orape ercmts no. mage-MRSnhasrelw aftbeifgnher lng thetert rendintrttuhniquecregiosition HetTualsosmov ofphoeesruif the dianue=ua oftthelthma clinbox tumses. Hr Gver, mage-MRSnmt="1 easoddto D2 cents="rl invMRelence waso asshodabolcs opracterization of tfsPGLs. theo strected oftthes acs onbnmt="1 gunce eenetl uhnng-st,aracterized beSDHxbiatio andintunknownenificant mima(the absebse wasthescrilo wittumsemsaex i), BA1ov ofgpe od boaisct_re maptheipprose a te pehicl Heiv>
    Mots-clés : crmAdé , AgedUHFees. , Hns, s,sMs. , Modabolcs os, MiddwitAgedUHMR-ctacucienopf, Parag sAsrama, Perieg> -Eiue Temptrlehic f, PocoleeMetic resRnance imaStacucienopf, , SurS acs onbsDehydrleens sANTumsemBurtifdiv>

  • LECWEGRZYK, GUYFOU A., LE FUR Y., AMAMAFFIULETTI N., VIGNALMEN CPERE M., RANMATTEI - P. ATPLACE NDUHBENDAHAN DPEREONDIN - P“RSciPloStolCpan> [En ligne]. 2015. Vol. 5, 10°6, pp. 707e0143972Disponible sur : < http://dx.doi.org/10.1016371/inalArt.alns.0143972(consulté le no date)
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  • Résumé : In Cultions amar(CONV)vlons,muscr diset_rerl invse or dn oft(NMES)a(t.ePERttest pul a duron Te,tl);efrence wl Hn thed bsdiaher in rategc resonaibliifhigpared to D2 unteer vistrolsions is (VOL). thetrolsist,eespr-pul a, her -frence wy (WPHF) NMESnmt="1 ek="it-0 0leictdteretrie :ej susg(t.ePERrMots-clés : crmbm, mskmskdiv>
    divul>2014

    href="http://dx.onk.pelibr vi.wiley.par/.or.1002/nbmhuni22379/abslsionitle="IdeLs"> vtanrressource àimg src="plugins/auto/zotspip_spip_v1/images/zotero/go.(plg" alt="">
    iv>
    LECGOUR NDUHFELICIAN ODUHAIDIC, RANKORIC,LPERE ERIV. CPERCHANOINE VELIFORT-GOUNY S., SYLE M., RANCECCALDI, RANJEVA J. - P“Fasctional connectivity, Ncnges in aerencspatlaingruBA1esSciHns, Bn whiMing anpan> [En ligne]. 2011 Jungr2014ol. 5, 35°6, BA17072978-2994Disponible sur : < http://dx.doi.org/10.1002/nbmhuni22379(consulté le no 29 Octo 2015. 4div>
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    Résumé : In Atrefilar heasts/z,Iients andp thelaingrtifet Alzghtmer's dases sndNOAD) havedgtmenwM neocoral par alsl quahodipartlatorsupe (Bseysction cor BA1ithic ysthbe diaeral-tifet mat=dthe predases sndLOAD).sWherape tstrtnization casthewouioormerk dissa foraerencsnhasrnGvertbeifgestigate thAt T study focaimf ateracterized magbasconftional connectivity, Nc(FC) yer, HnndintNOADr BA1LOAD the wo up. Isdthe14Iients and=bir/mdr a pdases snduron Ted skelGver, Netative to pats/z-=bir/mdrtrols, p. Ar perej susgerstaw inr0ntent oi movlons,psychtical stroci qut).r. Metic resonance imaeing. A higu to chantificay1ithic ys sketing-state fMRFCsfrcng magmet:e predefaé ss">aiwork dis(DMN),cituclirirmenGdspatlain la hy fiwerSn AD,s the usesnior sentlatorsupwork dis(ATN)tuBA1dorso-aralizessenntal supwork dis(DLPFN),cr bi tramengesismHetTuuf,ulargl-s steewouioormerk dirnges in an NOADr BA1LOAD endorse p in ctnionffmens of skeferences we,rirl ably re dne htodiagnng mctagnngribun castheienhticalcincnges in.rHns Bn whiMing 35:2978–2994,r2014ol©r2013 Wiley Por satc phiI
    iv class="tags">Mots-clés : crmAgastheOifet, AgedUHAlzghtmerspones sANAthic y, Bn whiMing anANCs s-Crols, nSy fiwe,rCbral incCer lxrmbm, Gralaingrtifet Alzghtmerpdases s, Execue to ctional UHFees. , Hns, s,sge: C Pocsing anANCuter-Ar-Asted, d, esatf,EroImaicalcin,Erorto Net, wouioormerk dis,EroImapsychtical strTings, Oxyge UHSistics, NdhigTopi/div>

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    iv>
    LECGRAPPERON A P. RANVERSCHUEREN, VIGDUCLOS, AMAFORT-GOUNY S., SYLSIER E., ELILY SDOU A PDSYLE M., RANCOZZONEP“ GUYPOUGET GUYJEVA J. - P., JEAATTARIAN SWhoAsiated corween structural abnoskeftional connecle.otii conestol it in patamyothic Ontaralizeserosis, ad ci qu A byefereu tipeiveorI wit the re sclee or dn ofthniqueque . SciMierosep;forErortopan> [En ligne]. 2011 Aprilr2014ol. 5, 49°6, 4A1707551-557Disponible sur : < http://dx.doi.org/10.1002/nbmmus.23957(consulté le no 29 Octo 2015. 4div>
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    Résumé : In Iols,duon co:talsestigate thA altftional con skelctural abncovegr, T the prenecle.otii conlsiont(CST) ng magfereu tipeiveorIeing. A (DTI)s the use re sclee or dn ofthniqueque (TST) patients with a dimyothic Ontaralizeserosis, ad(ALS). Meth">M: Fce t strients with a dALS,e13 lthy voltrols, p (HCs), BA16rients with a dar GM mcolrilons,n (LMN)tdrome, egerstaw inrDTI BA1TST.sonaé s:tTusenobe fereu veiocwposher in an ALSrients witthbe HCs (P ; 0. 0.01)etTuseTSTcio (MTwposar GM an ALSrients witpared to h theHCs (P ; 0. 0.001)t clira LMNrients witpared to h theHCs (P ; 0. 0.05)etTuseraased Mrthe usenobe fereu veiocwposnecti dne hh the othecased Mrthe useTSTcio (MT(P ; 0. 0.01)etpas lu tis:tSificant metnecti dns notex-strween str useDTI BA1TSTssoué s,ricatc t magb in uctural abnoskeftional conestol it in the preCST patients with a dALS. Mieroserorto 49:551–557,r2014iv>
    Mots-clés : crmAdé , AgedUHimyothic Ontaralizeserosis, a,nin whi, sncDereu tipMetic resRnance imaIing. A, fereu tipeiveorIeing. AUHFees. , Hns, s,sMs. , MiddwitAgedUHPyramidparTsionshe r, scr, iparnetic resee or dn of,e re sclee or dn ofthniqueque iv>

  • href="http://dx.k.pngspg ther.par/acle.pn.1002%27/s10334-013-0396-1itle="IdeLs"> vtanrressource àimg src="plugins/auto/zotspip_spip_v1/images/zotero/go.(plg" alt="">
    iv>
    LECMAAROUF, VIGAU">SciMetic resRnance imaMraliid scpatPty os, Bigy RDFoske enicilCpan> [En ligne]. 2011HFebru vis2014ol. 5, 27°6, pA170753-62Disponible sur : < http://dx.doi.org/10.1016%27/s10334-013-0396-1(consulté le no 30 Octo 2015. 4div>
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    Résumé : In Oej su Sodium iratmr dn oftps estol in thelons,nconesjuvisorate thetermiple sclerosis, a (MS). Wseaime htodici quisodium iratmr dn oftpatirgehing to MS, knownetodsurencsm thelGvereelons,nconesjuvi.aMraliid sc motoeth">M 3D-23Na- witwposerned imaTed 3T-MR-cnbe iM an 20tirgehing to MStients wit[11ese o vi-irgehing to (PPMS)r sken witsesuld vi-irgehing to (SPMS)]d fou15ntrols, p. Tl supsodium cas wntions not(TSC) hin theehiatter, Hf(GM),rmaliza-apt 0 thehe matter, Hf(WM)r ske ds note inc/jaterizAt Sistics, parneng andaesis iosnfeT C bmalizat( asse obsu foupiciali A.sonaé s Prgehing to MStients wittr qs wimaher in GM–T C ues and(48.8 ± 3.1 mmol/lse tasue in untA1 ; 0. 0.001)t cliT2 ds no-T C ues and(50.9 ± 2.2 mmol/lse tasue in untA1 = 0.01) pared to D2 GMfoperWM Lifplols, p. Sistics, parneng andaesis stud(); y TSCeraased MscpatPPMSrients witpanfd imaD2 mcolri skeloed osiveoryenecle.we,rirnntal supnecle.we,ri notaBA1nbralellum. theSPMS, TSCeraased Msc as p ssated with impas theestol an:ese o vi mcolr,rirnmcolri skeloed osiveoryenecle.we;rirnntal su, c-stues
    Mots-clés : crmAdé , AgedUHBighodicmicEng teer ma, Bn wh, Bn whiMing anANCs s-Crols, nSy fiwe,rCuter-Ar, ppl.ira Life Syce/awe,rbm, GraDlaabiedofUHFees. , Ghiatter, HetHthy v thmat=bi os, Hns, s,sge: and/ Radigy RD, Metic resRnance imaIing. A, Ms. , MiddwitAgedUHMRIUHMiple sclSrosis, a,nrorto Fibtan,(Myels onbd,EroIma s,sPrgehing to miple sclerosis, a, Sodium, Solid SistetPty os iv>

  • iv>
    LECPEDREIRA CPERVAUDANO, G, ELITHORNTON R. CPERCHAUDHARY U GUYVULLIEMOZ, SYLLAUFS HGUYJODIONOV RGUYCARMICHAEL DWSYLLHATOO SDSYLE M., RANQUIAN QUIROGA RGUYLEMIEUX,LP “Cs="rlatcon castheEEG bmalizat( asspatierl to epilepsyeh a dh.miplaneite EEG-f witrenerd-lea . SciroImage: Cpan> [En ligne]. 2011HOcto 2015. 4ol. 5, 99A1707461-476Disponible sur : < http://dx.doi.org/10.1016%16/i.lons,ges/z.2014o05.009(consulté le no date)
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    Résumé : In ScalpeEEG renerd-leas the usecs="rlatcon castheaa-heictto epilepierat=dplaract in (IED) patients with a depilepsyeprovnce ue=ua witthmat=bi oftaboals strepilepileenOntmerk di,tierl cr dily byefefin magthambd:urarieosnfe dia"irreive mo z;">" (IZ), BA1he wasachahelpful dug thepre- : al strnue=ua ofttheients with a dlGvereernntaci traepilepsi HetTuseate s wtected oftaBA1ns="rlatcon castheepilepierat=dnifid sc qu al toly re grtigortert obsortorHetTualsosma vtayeprovnces pt:s, par sketilia witthmat=bi oftre dne htod diaIZeercmition casbeyothe use hanprovnceA byepealiite ppromen HetWseappl DubWave_ lu,gae s/zoed ma p_vkon Drn magalgot:shm,r the firns="rlatcon castheIEDrvisusu a etifier ldsm thepre- : al strh.miplaneite Et_reroe waphalaphim-ftional conMetic resRnance imaIing. . A (EEG-f wi) renerd-leaspat8eients witiched at thernntaci traierl to epilepsyecsur e)M wposgoon,nprovnc magadful d=bir/stheEEG yer, Hnndan 2 nbses,s ng-n TemicEEG thmat=bi oftan 2 orape nbsess sk,ttheeenersu, cover magEEG yer, Hnndnfe dias="ipas thehigortert ns="rlatcon casthe7dnfe dia8 nbses. Mhstg onably,rnue=ua oftthe althodh">eh a dEEG-f wite)ye="ma mapstre dne htod diamajor, T theIEDrns="rin eatr qs w thetmprovwitcicialie imsthbe diavisusupIEDrns="rlatcon ca-ed on aesis stu(72% vtante 50%).sFurrapem, two diaIED-re dne hBOLDrnges in r Attachment Exporter la référence : BibTeX | MODS | Refer/BibIX | Bibliographic Ontology RDF | Zotero RDF | Wikipedia Citation Templates

  • iv>
    LECTASO, RANLEETER A., G, SDIKA, RANJEVA J. - P., JEAE M., RANBERNARD, RANCALLOT VP “Cultctura maptheinrtheo strhns, tii connerd ats="ned on novher -onanlun casMR ges/zo atermrvl inv the uotacOntals ts:eseilimi cryssoué s . SciMetma (Now Y di,tN.Y.)pan> [En ligne]. 201Juhan2014ol. 5, 27°6, 3A1707257-267Disponible sur : < http://dx.doi.org/10.1002/n7/s10334-013-0403-6(consulté le no date)
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    Résumé : In OBJECT: O: atl mae MA A.IALSrAND, ETHatnrngusu a ed on novposi-mer lmesemgenermapdata.sFurrapesk dirwillssultsprr covegrmn casthtodines/zoed in C egt).rd met_v1els eeiv>

  • href="http://www.ncbsyce/awdenGct.par/syce/aw/acle.pn.pii/S1053811914004601itle="IdeLs"> vtanrressource àimg src="plugins/auto/zotspip_spip_v1/images/zotero/go.(plg" alt="">
    iv>
    LECWIRSICH GUYBÉNAR CPERJEVA J. - P., JEADESCOINS, RANSIER E., ELILEETER A., G, FORT-GOUNY S., SYLLIÉGEOIS-CHAUVEL CPERE M., R “S-letypeiid tEEG-thmat=e hf witrSciroImage: Cpan> [En ligne]. 20115HOcto 2015. 4ol. 5, 100A1707325-336Disponible sur : < http://dx.doi.org/10.1016%16/i.lons,ges/z.2014o05.075(consulté le no 4 August15. 4div>
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    Résumé : In S.miplaneite EEG-f withasrot n Annprwow avenuassfsemtmprov mag firsiento-tlatorsuponanlun castheftional conin whisy fiwe. Hr Gver, s stuoeth">engusu a surencssm theposemEEG lifieofUHinr0nsis stu(ICA).aFthe altfirst t ondttrusas aps eh. ImICAtD2 /jateridlGversupthdat ntife1nomp;">intu(IC)scuctiniblc magtod dia ence we theionsvd metandsu to s-letypeiid tt 0ks asrs">r dn oftierarictanrpatadgenerconk.pearin">at (GLM)sthef wite)r dn of,clftuinerde imap the str ureirs ac qu morIC-ERPsnprovnc magan unpreneds wimasiento-tlatorsupracterized bi oftnhe altwholirtrgnie morircsing asrfefinat theBOLDrnifid rs">r dn of. Bheng mag fie ppromen,i strcer, HnftheEEG-thmat=e hBOLDrs">r dn oftirovnceA tmprovwitracterized bi oftnhe altmerk direstol in thbe strf wi-onngrunsis stuthe altrce à reneltctura mapthe str ureirERPs; diaera la hniquequetud(); magme a ow natgs notin ctnionfercmitie hra firoraiplic;pe (Beiv>
    Mots-clés : crmbm, GraEvok AnPot al tos, Face renegnie on,tICA, S.miplaneite EEG-f wi, Vwntiolavisusupienhway iv>
  • divul>2013JnalArt icle.pn

    iv>
    LECBARTOLOMEI, BREBETTUS GRANSTAM C GUYE M., R “Ia-heictto merk dirsecper( asspatmesipartlatorsupe (Bsepilepsy: A phic fi RDs, pardy focm theintiocbral increnerd-lea . SciCliuecreglons,pty gy RD:uoreic to rnalArtpthe strIa-henanal conFedsrbi oftnheCliuecregNons,pty gy RDpan> [En ligne]. 201Denem 2015. 3ol. 5, 124°6, p2A17072345-2353Disponible sur : < http://dx.doi.org/10.1016%16/i.cliuph.2013.06.003(consulté le no date)
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    Résumé : In OBJECTIVE: Ghic fi RDs, parunsis stutfeftional connectivity, Nce) d bi oftlikelihood (SL)cwposnalcu dne hween struct_ree hpa-iocbral incet_reroces pal scttuD2 erned SLb-lt="1in phic s. Me, malizatie h lute thetedlxrmaversgtrcerhs dngtheaskelmall k dl htedlx See obscalcu dne hD2 nacterized ltmerk dir/10a d bi of. RESULTS:tBroadbaskeSLeues ande obsher in an tuseMTLE eh. I. Althoughd small-k dl hcer, Hnfwposfd:ur an tuseow neh. Is, malizatie h lute thetedlxv the oea l qu r /jaeBA1iversgtrcerhs dngthee obsher in an tuseMTLE eh. I. CONCLUSIONS:talsfemeltctst Ad trethe owardga mhoeetituesr (l qu r thom)tpanfdgurbi oftnheaa-heictto epilepileenOntmerk din. the ng-n Te Setedlxvwposfd:ur D2 nucti dneth a depilepsyedurbi of. SIGNIFICANCE:tTusstr opgy R, parulterons notmt="1ieasar : roe thao vkeranhehns, fo.to epilepsa skeplarloiifs, egnges in over t oneiv> Attachment Exporter la référence : BibTeX | MODS | Refer/BibIX | Bibliographic Ontology RDF | Zotero RDF | Wikipedia Citation Templates

  • href="http://www.ncbsyhgwe-rnalArt.par/acle.pn.S0920996413005707/abslsionitle="IdeLs"> vtanrressource àimg src="plugins/auto/zotspip_spip_v1/images/zotero/go.(plg" alt="">
    iv>
    LECFAGET-AGIUS CPERBOYER,LPERLANçON CPERJICHIERI RGUYFASSIO, ELISIER E., ELICHANOINE VVIGAUQU E.,PPERJEVA J. - PPPERE M., R “Sctural abnoskeftional conre/10a d bi ofanhek di andoemeryisystla dug thetusefirst depasonwhischizophgwnia. A cross-seonal condy fo . SciSchizophgwniasRnaearchpan> [En ligne]. 2011HDenem 2015. 3ol. 5, 151°6, pA170748-60Disponible sur : < http://dx.doi.org/10.1016%16/i.schgwe.2013.100023(consulté le no 29 Octo 2015. 4div>
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    Résumé : In Iols,duon co Prgehing to athic isoratesspatin whiatgs notintol in the altw di andoemeryimerk diralomag firschizophgwnia's patese, bun h thoalsieralletrnunlun casthew di andoemeryiimpairt).r.talsestigate thA altftional con/10a d bi ofaintspretualsderk dirat feree s wtsts/zo the strplaed M. Meth">M Tw iny-ht="1eients with a dlchizophgwnias(16th a darmagfeaed Medurbi of (>60 melths) ske12th a dlher gfeaed Medurbi of (<60 melths)) skeeals n lthy voltrols, p erstaw inructural abnoskeftional con witeug the, m-kgro task D2 ectermehanathic is BA1ionsvd metyer, Hnn. onaé s Atrilar heam-kgro cicialie imsr sketilve mo pat/her gfeaed Medurbi of ients wi,tarmagfeaed Medurbi of ients witionsvd eotooreental suptlatorsupparie sup perntal supderk direug the0-kgro ske1-kgro taskscr ai trarolirdug thetusefirst t n y 0 srtheschizophgwnia.iv>
    Mots-clés : crmbm, GraDeaed Medurbi ofUYFtional con wiLISchizophgwnia, snc, W di andoemery iv>
    Attachment href="http://wwwbm.univ-amu.fr/spip.php?page=zotspip_unafilep;id=9G_zm"> =BVREJ94M">Si-i/het> | (href="http://www.ncbsyhgwe-rnalArt.par/acle.pn.S0920-9964(13)00570-7/abslsioni>rce à> | )

  • iv>
    LECKORIC,LPERJEVA J. - P., JEAFELICIAN OJEAE M., RANDE ANNA, BRESIER E., ELIDIDIC, RANCECCALDI, R “Cueketiainlenob : ittr dicttuDfirprgehing casthephiatter, Hfathic istheients with a damnesecemildgtrgnie morimpairt).r.. SciDit inia skeeliidc eletrgnie morfeaerderspan> [En ligne]. 2015. 3ol. 5, 36°6, 3-4A1707197-210Disponible sur : < http://dx.doi.org/10.1016159/000351667(consulté le no date)
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    Résumé : In Amnesecemildgtrgnie morimpairt).r (aMCI)sosma hcterleeneite syndr, egthbticoullieassubatvnce hpa-orfeatiionglons,psychgy R, pariatioinp. T2 aatigate thatilve ulthipshween str strwol ,psychgy R, parprgfilestheoemeryiimpairt).rrat ed olehanandr strwol ,ie: andcer, Hnftheehiatter, Hf(GM) losn over 18 melths,2cresiciali An0scessiacu mosunluric elein whisy fgrtig31 aMCI ients witindr29d=bir/e h lols, p. Anles ej susoe obs
  • divul>2012JnalArt icle.pn

    iv>
    LECJONAS GUYDESCOINS, RANKOESSLER,LPERCOLNAT-COULBO(En SYLSAUVÉ., RANE M., RANVIGNAL - P., JEAVESPIGNANI HGUYJOSSION BGUYMAILLARD,LP “Fo.to et_rer, parpa-iocbral incgatmr dn ofttheopface-s"> ie moras t cau Mso ra> i).rtcessoe=znosia . SciroImasyce/awpan> [En ligne]. 20111HOcto 2015. 2ol. 5, 222A1707281-288Disponible sur : < http://dx.doi.org/10.1016%16/i.lons,syce/aw.2012.07.021(consulté le no date)
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    Résumé : In Face pe àpt ofattudubaeBAat thea largl fet ofpas thethe usehns, vwntiolaoraiplio-tlatorsuprer lx. Hr Gver, s earolirthe stsipas thehndr stiemtmper e ima theface renegnie onurem whilarglngrtioloaietHegbdttreater ganid Mrthe ra> i).rtsct_re mosimpairt).rrtheface renegnie onu(cessoe=znosia) paducat thefo.to et_rer, parpa-iocbral incgatmr dn oftthe pat e="1einfor senoraiplic;pgyruHetTualsas t tr qs with a de=", parface-s"> ie meioc sgevnce imt theftional conwol ,ie: and e="1eoraiplic;pface as t (OFA).aApface-s"> ie morpa-iocbral incN170vwposa fourenerde hpattualsas t,uduppDrn magiwit lolsibun casposatrce à nhe altwell-knowncN170vnomp;">inre=", paly renerde hnov firscalp. Altogerape,e stsipobsortons notlfdtconegthbtiface renegnie onucanieassct_re molydimpairldstheercmigfearupn ofttheops-letypface-s"> ie moras t nhe altmerk dirdubaeBA mag fie ftional ,e pat e="1eOFA.iv>

  • iv>
    LECTREBUCHON ARANE M., RANTCHERNIACK VVIGTRAMONI ELIBRUDER NGUYMETELLUS PP “[Ia-heeststheEEG renerd-lerdug thedenGct et_rer, pargatmr dn oftfsembn wh heng andction(){nwhis: aevi] . SciAnArtassfra>çai Msod'anesthè i) et defèani=bi ofpan> [En ligne]. 201Juhan2012ol. 5, 31°6, 6A1707e87-90Disponible sur : < http://dx.doi.org/10.1016%16/i.annfaie2012.04.010(consulté le no date)
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    Résumé : In Bn wh tumthe : aevisosmatt esk whens ds notarroercm in theelonce ttas thetTusera-heicatvncuparinatcso-ftional coniatiobiedof nhe altcwntiolanortite systla ifootMso pateen whis: aevish ththeelonce ttatgs notmay paducanwol ,y R, par encelae. Bn wh heng andng magpa-iocperae morfenGct et_rer, pargatmr dn oftlftuwakeeients withastbeifgfsemarmague=idst Ad sg first mdarda theftional conin whiheng an.sponGct et_rer, pargatmr dn oftlfduoimagaeercmig ra> i).rtet_rer, paroskeftional confeaer0a d bi ofatsssultsprr Anpo ie morphe str ask siciali Anbyi strceri).rtisgfeaturbedetTusein whi s t gatmr dnin tsg finssultsprr An sgess al tor the firction(){n ief nhe altgatmr dn oftduo pat usehcterleeneief nheexclicbiedof urew()llior feree s wtnecle.to s th) thefalsanpo ie mor(ate ).rtspdy(f,era-heatgs npargifid riecpagae onureniblne sur theremro/ ereects,ech commakeefere cr tetusera-hetr rd mestheio ie morthewogae morbehav ol abnereects)tpansns(umat limitdn oftthe ptsg niqueque. T2 amprovwd dia e> ie meioc skeliac fecief nhe atsg niqueque,dttrusay inret_reronecle.aphic Ontrenerd-lersystla all); magessomig ondvisusud bi oftnhe altercmi.talsirovnce usincevnce imsthbtefenGct necle.to gatmr dn oftcombinat h a det_reronecle.aphic Ontrenerd-lercoullieasu tful D2 ectecteremro/ af la plarhargl the oeadjust1gatmr dn oftierarictan. the ng-n Te stsg niquequeaorencsnwow pncsiacu mosD2 ber, Hfaci qunnectivity, NcLifpbral incmerk din.iv>
    Mots-clés : crmBn wh, Bn wh Meng anUYBn wh Neoy:nsms, Et_rerece atmr dn of, Et_reroe waphalaphiphfUHHns, s, roImas: aevi, roImas: ae.to Prcsidl we, Peecperae morCagb,2Wakefulning.iv>
  • divul>2011JnalArt icle.pn
    .0020071itle="Identifier la ressource à partir de son DOI">
    iv>
    LECBETTUS GRANJEVA J. - P., JEAWENDLING, BREBÉNAR CP GRANFORT-GOUNY S., SYLRÉGIS GUYCHAUVEL PRANFOZZONE PP JELILEMIEUX,LPERBARTOLOMEI, BREE M., R “Ia-heictto ftional connectivity, Ncnhehns, epilepiOntmerk dinraci queA byiaa-iocbral incEEG theBOLDrnifid rfluralons no . SciPloS ;">pan> [En ligne]. 2015. 1ol. 5, 6°6, 5A1707e20071Disponible sur : < http://dx.doi.org/10.1016371/inalArt.p;">.0020071(consulté le no date)
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    Résumé : In Ie stsgsy fg,dttraime h oefemeltctst wherapesnibllaneite fluralons noethe useblood oxygens dve tdat ntift (BOLD)rnifid rdheivldsm omssoun magstst ftional conmetic resrnance imaie: and(f wi)srnft_resnibllaneite wol , con vity, Nctheienhgy R, parbn whiatgs notastwell thetheatgs notsed to byiepilepiOmat= plarharglHetTualsosma cruc to issu p snnehe s wtfluralons noethef witnifid shween strremro/ in whi s totarronowdth=lngrtse h oefefina ftional connectivity, Nctheity gy RD thetheienhgity gy RD.talsliffier ldsmtional connectivity, Ncng mage;"-k.pearinob : ioethecross-cucti dn Temween struifid sherned imam theintiocbral incEEG (iEEG)r sketiun ma-stst ftional con wit(f wi)sthe5eients witsurenc andc theintiocta surtlatorsupe (Bsepilepsy (TLE).aFtional connectivity, Ncwposliffier ldsh a dboa dmodfieo asspat s totexhibit thederee s wtet_reroity gy Re.to gasMots-clés : crmbm, GraEt_reroe waphalaphiphfUH

  • iv>
    LECGOUR NGUYJEVA J. - P., JEACECCALDI, RANFORT-GOUNY S., SYLBARBEAU, ELISIER E., ELIE M., RANDIDIC, RANFELICIAN OJ “Bassupftional connectivity, Nch ththe use tior sentlatorsupmerk diresp ssated with impcicialie imrtigdass=rve mo oemery tasks . SciroImaIingwpan> [En ligne]. 20115 Sepiem 2015. 1ol. 5, 58°6, 2A1707687-697Disponible sur : < http://dx.doi.org/10.1016%16/i.lons,ges/z.5. 1o05.090(consulté le no date)
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    Résumé : In Sibllaneite fluralons noethe useblood oxygenbi oftldve -dat ntift (BOLD)rnifid ,casrsob : imatheftional conmetic resrnance imaie: and(f wi)satt est,texhibitd tlatorsulynnehe s wt vity, Ncthoughtspatrnft_resftional coly reldv metwork din. Atioro-mesipartlatorsupuctural wetarro dia ieehtheeaingrcerhgy R, parnges inetheAlzghtmer'sgfeaed MeaskehamorbestruhowncD2 be pt:le.to thedass=rve mo oemery O: inrAnsis stutnetiun ma-stst f wiLIweaextioct An0sreldv metutior sentlatorsupmerk dir(ATN)rnomp;se hnhe altpor rhthto aske>inorhthto rer lx, firhippoc;foto hy(f,e use mygdalanandr stresltmerk dir BA1intexecue mo- lols, tmerk dire obsa fouuct_ree hpat/erv p snneols, tmerk dis.talsfirst pared to bassupftional connectivity, Ncnhe altATN ween strients witindrneols, ts ej sus. Rilve mo pat lols, p,2ients witexhibitednsifi fec melydiaased ldsmtional connectivity, Ncthe useATN dug thetiun. Siac feccoly, voxe -basay insis sturdveal y inrtaased lch ththe useinfor senaskesupor sentlatorsupgyruHnandr strtiouHetthe strceri).rteh. I,eio ie morcucti dn Tesoween striversgtdnnectivity, Ncues andnheATN askeiicialie imrtigutioraphider sketitraphideroej su-basay oemery tasksre obsobsorte ,mch le2norcucti dn Tefwposfd:ur h a dorapeseues dne htrgnie mornob : io.tTusstrcucti dn Tesoe obsliac fecetat useATN,casrnorcucti dn Tefween striicialie imrtigoemery tasksrandr strorapesuct_ree hmerk dinrwposfd:ur.tTakstr ogerape,e stsipfilc massirovnce evnce imsthbtebassupnectivity, NcintspretuseATN merk dirhposatftional conrolirtheoej su-ti dne ,t lol/ja-m eeeoemery.aTusysa fouuugglHtsthbteiaased ldsnectivity, Ncatt estch ththe useATN coullirnft_respare"> ai tramengesismso pateorate theatniblno pateaingrcerhgy R, parilté .iv>
    Mots-clés : crmAge ,tAlzghtmeraDeaed M,mbm, GraD)inrAnsis st, Psychgmoi t Picialie im,mplatorsupLo 2, Visusu Picàpt of.iv>

  • iv>
    LECGUEDJ ELIBETTUS GRANBARBEAU, E JELILIÉGEOIS-CHAUVEL CRANFORT-GOUNY S., SYLBARTOLOMEI, BRECHAUVEL PRANFOZZONE PP JELIJEVA J. - P., JEAE M., R “Hyperaonsvd mettheiarahippoc;foto atgs nroskeftsOmat= gyruHnassated with impsucsiquful e od magpaamedipartlatorsupe (Bsepilepsy . SciEpilepsiapan> [En ligne]. 201Juhan2011ol. 5, 52°6, 6A17071100-1109Disponible sur : < http://dx.doi.org/10.1016111/i.1528-1167.5. 1o03052.x(consulté le no date)
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    Résumé : In PURPOSE: Picialie im theataegnie onuoemery deree Hnamoandcerts with a dmedipartlatorsupe (Bsepilepsy (MTLE).aWtraime h oefetermehanifrfeatiiongataegnie onucicialie imsr(malizahvs.dimpairld)rcoullieasti dne h oefeatiiongyer, Hnn Lifbn whi onsvd metdug thee od ma. METH Ieea onsvd mesrwhibies Ieea onsvd mesrwhiarntal su/oimau dneoaskeierie supmerk di.sRiaegnie onuiicialie imrw snnecti dne hio ie molyspatbies ai Tefw ththebies
    Mots-clés : crmAdolesc).r, Adé , bm, GraEpilepsa, platorsupLo 2, Fem le, Hns, s, Metic resRnance imaIing. nUYM le, MiddsurAge ,tParahippoc;foto GyruH, Pessiacu mosStudiet, Psychgmoi t Picialie im,mRiaegnie onu(Psychgy Ry), Yd:ug Adé .iv>

  • iv>
    LECHEWETT RELIE M., RANGAVARET, RANBARTOLOMEI, B “Benignrtlatoro-ierie o-oraiplic;pjtion(){nepilepsy e impviun buesr featurbe im:einr:urheataegnizod thmstheepilepsy?. SciEpilepsy p;forrbehav or: Ep;forBpan> [En ligne]. 201August12011ol. 5, 21°6, 4A1707412-416Disponible sur : < http://dx.doi.org/10.1016%16/i.yebeh.5. 1o05.017(consulté le no date)
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    Résumé : In We soipt:bat ser asstheadolesc).rsoaskeadé suwho sharro diaet_reron Co, parngeioct r sle.ssthearwon ds nto, pgeimacorMsiblnevBsepilepsy ie ifoun magassiromehantpviun buesr featurbe ims,uuugglHt magestlatoro-ierie o-oraiplic;p(TPO)pjtion(){noris/a.aWtrtitrasiacu moly review An0se)R to tat uBsepilepsy n Co, over a 10-yeheacicioith imprMsi_restat uBsfoll); magpt:l/rip:eatate ).rtepisocesttheiaroxysizahviun buesr symptoss,mmalizah wiLI theth-heictto EEG nges ineover firposior senatgs no. Fce t strients wite obsfi coly uct_ree h(10 m les,m4 fem les). MeuBrugl t ultetrw sn26.5 (res i: 12-59)etTuse Ciznosisstheepilepsyrw snususulysde:noe hufiel af la card gy RD th/senonorhtholcrynggy RD k diupetTusep toomeh metf 0 : ioetneth-heictto scalp EEGsoe obsabmalizato assover firposior senas thetAluppants witersibldednwell D2 ffieepilepiOntmedicanal .talsirop;seo patehy vough fe tapesngeioct r bi ofatssneedto tatlabel itd syndrome, utss:urhe Ciznosod thmstheepilepsytmeriwiteraegnie on.iv>
    Mots-clés : crmAdolesc).r, Adé , AgMrtheOltet, Bn wh Meng anUYChilm, Et_reroe waphalaphiphfUHEpilepsiet, Pir dto,

  • iv>
    LECTHORNTON RELIVULLIEMOZ, SYLRODIONOV RELICARMICHAEL D.taBRECHAUDHARY UP JELIDIEHL BGUYLAUFS HGUYVOLLMAR CP, MCEVOY A.taBREWALKER, R CPERBARTOLOMEI, BREE M., RRECHAUVEL PRANDUNCAN - PSELILEMIEUX,LP “EpilepiOntmerk dinrthefrcmigplcle.to fyay:nsiaurdveal y ng maget_reroe waphalaphiphf-ftional conmetic resrnance imaie: an . SciAnArtssthewol ,y Rypan> [En ligne]. 201Novem 2015. 1ol. 5, 70°6, 5A1707822-837Disponible sur : < http://dx.doi.org/10.1016%02/ana.22535(consulté le no date)
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    Résumé : In OBJECTIVE: S: ae.to tdy(tt).rrnhefo.to epilepsyteheients with a dfrcmigplcle.to fyay:nsiau(FCD)atssmost1gucsiquful ifgelupepilepileenOnttissu psturds_ree .aTstsgmay dat be evnce t ulpuctural conmetic resrnance imaie: and( wi),n Deintiocraniabnet_reroe waphalaphiphf (icEEG)rtssneedto tatdek.peatwd dia eizuobsoltetrz;"> (SOZ). EEG-ftional con wit(f wi)scanirdvealeth-heictto plarhargl (IED)-ti dne ehemrdye="Ontnges inethe useirrtion verz;"> (IZ).aWtraci queA useue="PstheEEG-f witeheients with a dFCD-assated witfo.to epilepsytbyiex="On thetuseti dn Teship been strIED-ti dne ehemrdye="Ontnges in, icEEGpfilc masLI theposicperae moroutcome. METHlle ,t sketiué suw obsoverlai hnovcorMg-st) to T1b-lt="1to witncane ftswith impcompu-ho tamaphiphf ncane s(); magtheeintiocraniabnet_rerodlHettED-ti dne ehemrdye="Ontnges inoe obscured to h imptheeSOZetnetcEEG theposicperae moroutcomet0 01 yehe. RESULTa: TwslvMrthe23eients withadttEDs dug thetinerd-le,t ske11rthe12thadtsifi fec mettED-ti dne ehemrdye="Ontnges inetTusef wittiué suw obssulnerd meth imptheeSOZethe5ethe11ecerts wi,talupthewhomthadtan DlincrysSOZetnetcEEG. Fce pthe5thadt>50%ttiduon(){nwhiseizuobsfrencencysfoll); magrds_re mors: aevietTuserem wh mag6ethe11ecerts withadtth=lspdy(fecrdplarerd metatgs notthetED-ti dne ef witnifid tnges i.aFivMrthe6thadteirapesaepothe : ae.to outcomet(<50%ttiduon(){nwhiseizuobsfrencency) theth=lspdy(feSOZepdy lud ands: aevie INTERPRETATION: Compd i DOItheEEG-f with a dicEEG sugglHtse pateEEG-f witmay irovnce u tful ng-n Tealethmat=bi oftaboutptheeSOZetheFCD.aWh=lngrfeatribu-ho plarerd metatgs notthetED-ti dne ehemrdye="Ontnges i appeheaD2 be assated with impaeth=lspdy(feSOZe thepotheposi : ae.to outcome.iv>
    Mots-clés : crmAdé , Bn wh, Et_reroe waphalaphiphfUHEpilepsiet, Pir dto, Fem le, Foll);-UpsStudiet, Hns, s, Metic resRnance imaIing. nUYM le, Malmat=bi ofottheClcle.to Ddve opt).r, MiddsurAge ,troImto Perhways, Perts wsponrhargl, Posicperae morPicioi, Peecperae morPicioi, Tdy(tt).rrOutcome.iv> Attachment Attachment Exporter la référence : BibTeX | MODS | Refer/BibIX | Bibliographic Ontology RDF | Zotero RDF | Wikipedia Citation Templates

  • iv>
    LECTRAMONI ELIFELICIAN OJANBARBEAU, E JELIGUEDJ ELIE M., RREBARTOLOMEI, BRECECCALDI, R “L> -termesulto=idst metthedass=rve mo oemery:cints="1em thetlatorsupe (Bsepilepsy . SciBn wh:paernalArtsthewol ,y Rypan> [En ligne]. 201March15. 1ol. 5, 134°6, P 03A1707816-831Disponible sur : < http://dx.doi.org/10.1016%93/bn wh/awr002(consulté le no date)
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    Résumé : In Sev/rparorticims witcarr Duboutph impaesubtetrthecerts with a dtlatorsupe (Bsepilepsy hamorfemeltctst drmalizahoemery iicialie imran snaldcrdsde:nootthedy alup(i.i.aminu Ieeade:noot(i.i.adnoottheteeks),uuugglHt magelterekel> -termesulto=idst metmengesisms.tTusstrmengesismsoe obsliac fecsulysinviun gst drwhiareh. Imthef mo adé -oltetrpgeimaco- e> ie me ients with a dtlatorsupe (Bsepilepsy,texhibit thesls retepisocOntmemeryicuateaintitfep_vtenmalizahiicialie imran snaldcrdizod memeryiaci qums wetthe sfirst orticims w, usemetiitudMrtheo/zobraphic Onzahoemery losnrwposeues dne hng magtitraphiderpncsl conmemery tasksrbasay mets rbto askevisusu culHettheboa dneldi mes,rrnaé suu();edninr:uususu U-shapedhcer, Hnfthecncsl conmemery impairt).r, e ompaqu andoost1nhe altpents wi'gnefl, sed andl);evpe,eciciois1nhe altchilmhooi, eaingradé hooioaskeiest1gev/rparteeks.aTstsgyrgfilerwposuugglHt vMrtheael> -termesulto=idst metimpairt).rrnhecncsl conepisoces,radeq dnelynnelto=idstay mver 'u()rt-term'ade:nootbun phidusulysialgor, ng firnaf la.tTusrnf RD,rwhiarsubtencent orticims w, ients wite obssubmitne h oeagyrgtoc, tsiac fecsulysdevise h oeinviun gst u()rtoaskel> -termesulto=idst metthesult/jausulydy":ur orticie imsr(episocOntmemery)tindrneol/ja-m eeethmat=bi oft(semffiec knowledgerandrsin(40-m" ss)etthe stru()rtoterme(1 h),hiicialie imran boa dnelt/jausulydm eeeindrneol/jausulydy":ur oemery tasksrethethtacwetAf la a 6-teekade:no,dl);evpe,eneol/jausulydy":ur oemery iicialie imrw snimpairldsch le2nelt/jausulydm eeeoemery iicialie imrrem whedhcrds_rte .aTstsgereectrethethdet ntift nhe ask dereicé yrandr strmodfieoytthedytcievc;p(dy alup sketiaegnie on)etNons,ges/ magstudieturdveal y tusep tse we tfnmildgmilsbo=intnges inoe ththemedipartlatorsupe (Bsuctural we.tTakstr ogerape,e stsiprnaé suu();t uBsex-st).we tfnderee s wtsulto=idst metsystlanoe ththedass=rve mo oemery.aTusysuugglHtsthbtemildgmidipartlatorsupe (Bsdysction(){scaniimpepretusebuild magendrstcbiedzst mettheepisocOntmemerietubun leamosel> -termesemffiec andrsin(40-m" ss mnemelOnttiocbhethtacweiv>
    Mots-clés : crmAdé , Ansis stutf Vd e im,mBn wh, Epilepsa, platorsupLo 2, Fem le, Fluorodloxygluc;seoF18, Hns, s, Metic resRnance imaSiactrascopyUYM le, MemeryaDeaerders,sMel sumRiaalu, MiddsurAge ,troImapsychgy R, parT/ate, Po ieg> -Emiss Tempamaphiphf,mRiaegnie onu(Psychgy Ry), Tims Facworg.iv>

  • iv>
    LECZANIN ELIJEVA J. - P., JEACORT-GOUNY S., SYLE M., RANDEN(EnDRANFOZZONE PP JELIGIRARD NR “Whvtenmer, Hnmerurons n nhemalizahhns, fe supbn wh. Atrwhivivondereus Temt).ssentioctaphiphf ny fg . SciBn wh skebehav orpan> [En ligne]. 201Novem 2015. 1ol. 5, 1°6, 2A170795-108Disponible sur : < http://dx.doi.org/10.1016%02/brb3.17(consulté le no date)
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    Résumé : In Worfemeltctst the uBsfirst one use biedofh oefetermehanihivivon theth uo RDF usetra> ie Tesoween str usemewhistagestthewhvtenmer, Hn(WM)nmerurons n whimalizahhns, fe useshng magmetic resrnance imadereus Temt).ssenie: and(DTI)ntioctaphiphf. Biophfs, parngeioct r sle.ssthewa, Hnmoi oftare u tdgassinrtadirectrpr (Bspateues dnerpr gsours n nhe usetissu pmerrix /10an bi ofatngplcle.o-p_vnto tdasuso(CSTs),uopiOntra Cie Teso(OR),eindrnerpuitcalloé o(CC)mes 17imalizahhns, fe useshortlogeA been str23eindr38rteeks nheglHtbi oft(GW)tindruct_ree hatricelydmetminiizahooi oftarierasus. Nonk.peahepolynomipar(thirfecrder) curv pfitt massnhemalizaizod l> itudthto askera Cilewa, Hndereus vto ass(Z-scorMs) posatftional rtheaganitifieryr sree deree s wtphd Mg tfnmerurons n h impsiac fecedye="Ons theemen WM b:urno e="c.tTusstrphd Mg may nectisibldh oefeatiiongcelluesr ls n suuuen posaxl con/10an bi of, myek.pons n ggra st, askemyek.pons n,ep tv ously reter lmatheorapeseh. Ismtneposi-mer lm fe useshng magimmunosi wh magmeth">M. Acnerd-lestat uBsDTIriarame, Hndye="OnsLIweauugglHtsthbtemyek.pons n (phd M 3) appehes eaingrthe useCSTs,sfoll);lmathe useOR skebhe useCC,prMsi_re moly.sDTIrtioctaphiphf irovnceosacsiquh oeagbee, Hn:urhesnald magthefe supWM merurons neiv>
  • divul>2010JnalArtsicle.pn

    iv>
    LECBETTUS GRANBARTOLOMEI, BRECORT-GOUNY S., SYLE EDJ ELICHAUVEL PRANFOZZONE PP JELIJEVA J. - P., JEAE M., R “RoleethedyHt magstst ftional connectivity, Nc witeheiume" ae.to inviun gstal rthemesipartlatorsupe (Bsepilepsy . SciJnalArtsthewol ,y Ry,ewol ,s: aeviLI thepsychia n> [En ligne]. 201Octa 2015. 0ol. 5, 81°6, 10A17071147-1154Disponible sur : < http://dx.doi.org/10.1016136/innp.2009.191460(consulté le no date)
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    Résumé : In OBJECTIVE: Tuseo/zho Hnaime h oefetermehan use biedofhthedyHt ma-stst ftional connectivity, Nc wit(fc wi)statla eheients witp tse t magh a dmesipartlatorsupe (Bsepilepsy (MTLE)ran theein clidusus dvel. METH It ie mdofhthe64%oaskeapsiac fecdofhthe91%e(p<0.001)etTuseoost1frencentngrfeanectivitdgased ne obs useennorhthmigplclexrandr stranior senhippoc;fousrthe useepilepiOnte (B,sch le2neltsaesRe t sulyshippoc;fousraskeamygdaes. CORCLUSIONa: Tstsgny fgrfemeltctst se patetusep tse we tfnBFCcthased lsningtheewon-epilepiOnttspreetheiaradoxecsulystuseoost1siac fecemark201theepilepileenOntz;"> lo.toisons n,eindruugglHtse patearsin(40edyHt ma-stst fc wircoullieasu tful ingtheeiume" ae.to aci qums wrtheMTLEt0 0inrtadilidusus dvel.iv>
    Mots-clés : crmAdé , bm, GraEpilepsa, platorsupLo 2, Fem le, Ftional conLalls, Anstomic, roImto Perhways, roImapsychgy R, parT/ate, Se> ie mdofhindrSiac fecdof, platorsupLo 2iiv>

  • iv>
    LECE EDJ ELIBARBEAU, E JELILIÉGEOIS-CHAUVEL CBRECORT-GOUNY S., SYLBARTOLOMEI, BRECHAUVEL PRANFOZZONE PP JELIJEVA J. - PPRANMUNDLER OJANE M., R “Picialie im theataegnie onuoemery isnnecti dne hh a dennorhthmi/cicirhthmigth-heictto milsbo=ism ingtlatorsupe (Bsepilepsy . SciEpilepsy p;forrbehav or: Ep;forBpan> [En ligne]. 201Decem 2015. 0ol. 5, 19°6, 4A1707612-617Disponible sur : < http://dx.doi.org/10.1016%16/i.yebeh.5. 0.09.027(consulté le no date)
    Afficher/masquer les détails
    Résumé : In the ng-n Testat uBshippoc;fous,s useennorhthmi/cicirhthmigplcle.lsn obsof, nginvolve hehetlatorsupe (Bsepilepsy (TLE). It has weensirop;sede patetusstranior seniarahippoc;foto uctural we y:no a key roleetheataegnie onuoemery.aWtrstudieA useuoxe -basay PET cucti dn Te ween strnum 201thecucticelydataegnizod targltsrwhiarneweataegnie onuoemery iaradigmI theth-heictto cerebrto milsbo=intrat thegluc;se,rwhi15 ients with a dTLEth a dhippoc;foto u.pnra stetthecured i DOIpatlthy vols ej sus,ecerts withadtdeased ld ataegnie onunhe argltsr(P<0.001)I thetpsies). Picialie im necti dne hh a dth-heictto milsbo=ism thetpsiesRe t suginvolvems wrtheennorhthmi/cicirhthmigplcle.lsntheataegnie onuoemery iheients with a dTLE, andruugglHte pateataegnie onuoemery iaradigmg may easu tful ingaci qu magenior seniarahippoc;foto ftional conststusrtheTLE.iv>
    Mots-clés : crmAdé , bm, GraEnnorhthmigClclex, Epilepsa, platorsupLo 2, Fem le, Fluorodloxygluc;seoF18, hippoc;fous,sHns, s, Mele, MemeryaDeaerders,sroImapsychgy R, parT/ate, Po ieg> -Emiss Tempamaphiphf,mRiaegnie onu(Psychgy Ry), Sion sle.sstheTopic, Sion sle.s, Noniarame,ric, Yd:ug Adé .iv>
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