Center for Magnetic Resonance in Biology and Medicine
CRMBM-CEMEREM UMR 7339

VILMEN Christophe

By arnaud le troter on 6 August 2018

VILMEN Christophe

christophe.vilmen@univ-amu.fr
Phone : +33491324816

CNS

MSK

Platform

Engineer

at CNRS

Infrastructure Manager

Engineer

Download my Resume (FR / EN)

Detailed Activities

1) Instrumentation engineering
Conception – Realization and exploitation of instrumental devices in MRI/MRS environment:
MRI probeheads small animal.
Several cradles for the strictly noninvasive functional investigation of the muscle of rat and mice.
Design of human ergometers (electronics, mechanics) @ 1,5T/ 3T and 7T.
Electronical devices

2) Maintenance
Ensuring device availiability and infracstructure requirements

3) New works
Planning and site follow-up

Keywords

  • Metabolism
  • Ultra-high field MRI
  • X-Nuclei
  • MRI / MRS probeheads
  • Instrumentation engineering
  • Electronical engineering
  • Skeletal muscle performance

General Information

Scientific collaborations:
– H2020 Project: Institut Fresnel and international consortium MCube integrating 8 international partners, led by AMU, related to the engineering for the application in MRI.
– Carnot Project (STAR Carnot Institute)
For theses 2 projects, conducting experiments for the development of MRI antennas for preclinical aspect and the complete construction of these for clinical applications.

Teaching

Supervision of students, Master and engineering schools involved in projects:
follow-up and help with the oral defense of the internship report.

Publications :

180164 VILMEN 1 harvard-cite-them-right-no-et-al 50 date desc year 2606 https://crmbm.univ-amu.fr/wp-content/plugins/zotpress/
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Michel, C.P., Messonnier, L.A., Giannesini, B., Vilmen, C., Sourdon, J., Le Fur, Y. and Bendahan, D. (2024) “Endurance training and hydroxyurea have synergistic effects on muscle function and energetics in sickle cell disease mice,” Blood Cells, Molecules & Diseases, 107, p. 102853. Available at: https://doi.org/10.1016/j.bcmd.2024.102853.
Michel, C.P., Bendahan, D., Giannesini, B., Vilmen, C., Le Fur, Y. and Messonnier, L.A. (2023) “Effects of hydroxyurea on skeletal muscle energetics and force production in a sickle cell disease murine model,” Journal of Applied Physiology, 134(2), pp. 415–425. Available at: https://doi.org/10.1152/japplphysiol.00333.2022.
Meimoun, L., Pecchi, É., Vilmen, C., Bendahan, D. and Giannesini, B. (2022) “Effect of citrulline malate supplementation on muscle function and bioenergetics during short-term repeated bouts of fatiguing exercise,” Journal of Sports Sciences, 40(17), pp. 1981–1990. Available at: https://doi.org/10.1080/02640414.2022.2123527.
Michel, C.P., Messonnier, L.A., Giannesini, B., Chatel, B., Vilmen, C., Le Fur, Y. and Bendahan, D. (2022) “Effects of Hydroxyurea on Skeletal Muscle Energetics and Function in a Mildly Anemic Mouse Model,” Frontiers in Physiology, 13, p. 915640. Available at: https://doi.org/10.3389/fphys.2022.915640.
Chatel, B., Bernit, E., Vilmen, C., Michel, C., Bendahan, D. and Messonnier, L.A. (2021) “In vivo muscle function and energetics in women with sickle cell anemia or trait: a 31P-magnetic resonance spectroscopy study,” Journal of Applied Physiology (Bethesda, Md.: 1985), 130(3), pp. 737–745. Available at: https://doi.org/10.1152/japplphysiol.00790.2020.
Hurshkainen, A., Dubois, M., Nikulin, A., Vilmen, C., Bendahan, D., Enoch, S., Glybovski, S. and Abdeddaim, R. (2020) “Radio Frequency Coil for Dual-Nuclei MR Muscle Energetics Investigation Based on Two Capacitively Coupled Periodic Wire Arrays,” IEEE Antennas and Wireless Propagation Letters, 19(5), pp. 721–725. Available at: https://doi.org/10.1109/LAWP.2019.2960610.
Chatel, B., Messonnier, L.A., Vilmen, C., Bernard, M., Pialoux, V. and Bendahan, D. (2019) “Ischaemia-induced muscle metabolic abnormalities are poorly alleviated by endurance training in a mouse model of sickle cell disease,” Experimental Physiology, 104(3), pp. 398–406. Available at: https://doi.org/10.1113/EP087430.
Béchir, N., Pecchi, É., Vilmen, C., Bernard, M., Bendahan, D. and Giannesini, B. (2018) “Activin type IIB receptor blockade does not limit adenosine triphosphate supply in mouse skeletal muscle in Vivo,” Muscle & Nerve, 58(6), pp. 834–842. Available at: https://doi.org/10.1002/mus.26306.
Chatel, B., Messonnier, L.A., Vilmen, C., Bernard, M., Pialoux, V. and Bendahan, D. (2018) “Exacerbated metabolic changes in skeletal muscle of sickle cell mice submitted to an acute ischemia-reperfusion paradigm,” Clinical Science (London, England: 1979), 132(19), pp. 2103–2115. Available at: https://doi.org/10.1042/CS20180268.
Messineo, A.M., Gineste, C., Sztal, T.E., McNamara, E.L., Vilmen, C., Ogier, A.C., Hahne, D., Bendahan, D., Laing, N.G., Bryson-Richardson, R.J., Gondin, J. and Nowak, K.J. (2018) “L-tyrosine supplementation does not ameliorate skeletal muscle dysfunction in zebrafish and mouse models of dominant skeletal muscle α-actin nemaline myopathy,” Scientific Reports, 8(1), p. 11490. Available at: https://doi.org/10.1038/s41598-018-29437-z.
Macia, M., Pecchi, E., Desrois, M., Lan, C., Vilmen, C., Portha, B., Bernard, M., Bendahan, D. and Giannesini, B. (2018) “Exercise training impacts exercise tolerance and bioenergetics in gastrocnemius muscle of non-obese type-2 diabetic Goto-Kakizaki rat in vivo,” Biochimie, 148, pp. 36–45. Available at: https://doi.org/10.1016/j.biochi.2018.02.014.
Chatel, B., Messonnier, L.A., Barge, Q., Vilmen, C., Noirez, P., Bernard, M., Pialoux, V. and Bendahan, D. (2018) “Endurance training reduces exercise-induced acidosis and improves muscle function in a mouse model of sickle cell disease,” Molecular Genetics and Metabolism, 123(3), pp. 400–410. Available at: https://doi.org/10.1016/j.ymgme.2017.11.010.
Fouré, A., Ogier, A.C., Le Troter, A., Vilmen, C., Feiweier, T., Guye, M., Gondin, J., Besson, P. and Bendahan, D. (2018) “Diffusion Properties and 3D Architecture of Human Lower Leg Muscles Assessed with Ultra-High-Field-Strength Diffusion-Tensor MR Imaging and Tractography: Reproducibility and Sensitivity to Sex Difference and Intramuscular Variability,” Radiology, 287(2), pp. 592–607. Available at: https://doi.org/10.1148/radiol.2017171330.
Wegrzyk, J., Ranjeva, J.-P., Fouré, A., Kavounoudias, A., Vilmen, C., Mattei, J.-P., Guye, M., Maffiuletti, N.A., Place, N., Bendahan, D. and Gondin, J. (2017) “Specific brain activation patterns associated with two neuromuscular electrical stimulation protocols,” Scientific Reports, 7(1), p. 2742. Available at: https://doi.org/10.1038/s41598-017-03188-9.
Chatel, B., Bendahan, D., Hourdé, C., Pellerin, L., Lengacher, S., Magistretti, P., Le Fur, Y., Vilmen, C., Bernard, M. and Messonnier, L.A. (2017) “Role of MCT1 and CAII in skeletal muscle pH homeostasis, energetics, and function: in vivo insights from MCT1 haploinsufficient mice,” FASEB journal: official publication of the Federation of American Societies for Experimental Biology, 31(6), pp. 2562–2575. Available at: https://doi.org/10.1096/fj.201601259R.
Chatel, B., Messonnier, L.A., Hourdé, C., Vilmen, C., Bernard, M. and Bendahan, D. (2017) “Moderate and intense muscular exercises induce marked intramyocellular metabolic acidosis in sickle cell disease mice,” Journal of Applied Physiology (Bethesda, Md.: 1985), 122(5), pp. 1362–1369. Available at: https://doi.org/10.1152/japplphysiol.01099.2016.
Fouré, A., Duhamel, G., Vilmen, C., Bendahan, D., Jubeau, M. and Gondin, J. (2017) “Fast measurement of the quadriceps femoris muscle transverse relaxation time at high magnetic field using segmented echo-planar imaging,” Journal of magnetic resonance imaging: JMRI, 45(2), pp. 356–368. Available at: https://doi.org/10.1002/jmri.25355.
Chatel, B., Hourdé, C., Gondin, J., Fouré, A., Le Fur, Y., Vilmen, C., Bernard, M., Messonnier, L.A. and Bendahan, D. (2017) “Impaired muscle force production and higher fatigability in a mouse model of sickle cell disease,” Blood Cells, Molecules & Diseases, 63, pp. 37–44. Available at: https://doi.org/10.1016/j.bcmd.2017.01.004.
Béchir, N., Pecchi, E., Vilmen, C., Le Fur, Y., Amthor, H., Bernard, M., Bendahan, D. and Giannesini, B. (2016) “ActRIIB blockade increases force-generating capacity and preserves energy supply in exercising mdx mouse muscle in vivo,” FASEB journal: official publication of the Federation of American Societies for Experimental Biology, 30(10), pp. 3551–3562. Available at: https://doi.org/10.1096/fj.201600271RR.
Martin, A., Grosprêtre, S., Vilmen, C., Guye, M., Mattei, J.-P., LE Fur, Y., Bendahan, D. and Gondin, J. (2016) “The Etiology of Muscle Fatigue Differs between Two Electrical Stimulation Protocols,” Medicine and Science in Sports and Exercise, 48(8), pp. 1474–1484. Available at: https://doi.org/10.1249/MSS.0000000000000930.
Layec, G., Bringard, A., LE Fur, Y., Micallef, J.-P., Vilmen, C., Perrey, S., Cozzone, P.J. and Bendahan, D. (2016) “Mitochondrial Coupling and Contractile Efficiency in Humans with High and Low V˙O2peaks,” Medicine and Science in Sports and Exercise, 48(5), pp. 811–821. Available at: https://doi.org/10.1249/MSS.0000000000000858.
Béchir, N., Pecchi, É., Relizani, K., Vilmen, C., Le Fur, Y., Bernard, M., Amthor, H., Bendahan, D. and Giannesini, B. (2016) “Mitochondrial impairment induced by postnatal ActRIIB blockade does not alter function and energy status in exercising mouse glycolytic muscle in vivo,” American Journal of Physiology. Endocrinology and Metabolism, 310(7), pp. E539-549. Available at: https://doi.org/10.1152/ajpendo.00370.2015.
Fouré, A., Nosaka, K., Gastaldi, M., Mattei, J.-P., Boudinet, H., Guye, M., Vilmen, C., Le Fur, Y., Bendahan, D. and Gondin, J. (2016) “Effects of branched-chain amino acids supplementation on both plasma amino acids concentration and muscle energetics changes resulting from muscle damage: A randomized placebo controlled trial,” Clinical Nutrition (Edinburgh, Scotland), 35(1), pp. 83–94. Available at: https://doi.org/10.1016/j.clnu.2015.03.014.
Wegrzyk, J., Foure, A., Vilmen, C., Ghattas, B., Maffiuletti, N.A., Mattei, J.-P., Place, N., Bendahan, D. and Gondin, J. (2015) “Extra Forces induced by wide-pulse, high-frequency electrical stimulation: Occurrence, magnitude, variability and underlying mechanisms,” Clinical Neurophysiology, 126(7), pp. 1400–1412. Available at: https://doi.org/10.1016/j.clinph.2014.10.001.
Fouré, A., Wegrzyk, J., LE Fur, Y., Mattei, J.-P., Boudinet, H., Vilmen, C., Bendahan, D. and Gondin, J. (2015) “Impaired mitochondrial function and reduced energy cost as a result of muscle damage,” Medicine and Science in Sports and Exercise, 47(6), pp. 1135–1144. Available at: https://doi.org/10.1249/MSS.0000000000000523.
Jubeau, M., LE Fur, Y., Duhamel, G., Wegrzyk, J., Confort-Gouny, S., Vilmen, C., Cozzone, P.J., Mattei, J.P., Bendahan, D. and Gondin, J. (2015) “Localized metabolic and t2 changes induced by voluntary and evoked contractions,” Medicine and Science in Sports and Exercise, 47(5), pp. 921–930. Available at: https://doi.org/10.1249/MSS.0000000000000491.
Layec, G., Bringard, A., Le Fur, Y., Micallef, J.-P., Vilmen, C., Perrey, S., Cozzone, P.J. and Bendahan, D. (2015) “Opposite effects of hyperoxia on mitochondrial and contractile efficiency in human quadriceps muscles,” American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 308(8), pp. R724-733. Available at: https://doi.org/10.1152/ajpregu.00461.2014.
Wegrzyk, J., Fouré, A., Le Fur, Y., Maffiuletti, N.A., Vilmen, C., Guye, M., Mattei, J.-P., Place, N., Bendahan, D. and Gondin, J. (2015) “Responders to Wide-Pulse, High-Frequency Neuromuscular Electrical Stimulation Show Reduced Metabolic Demand: A 31P-MRS Study in Humans,” PloS One, 10(11), p. e0143972. Available at: https://doi.org/10.1371/journal.pone.0143972.
Yashiro, K., Tonson, A., Pecchi, É., Vilmen, C., Le Fur, Y., Bernard, M., Bendahan, D. and Giannesini, B. (2015) “Capsiate Supplementation Reduces Oxidative Cost of Contraction in Exercising Mouse Skeletal Muscle In Vivo,” PloS One, 10(6), p. e0128016. Available at: https://doi.org/10.1371/journal.pone.0128016.
Macia, M., Pecchi, E., Vilmen, C., Desrois, M., Lan, C., Portha, B., Bernard, M., Bendahan, D. and Giannesini, B. (2015) “Insulin Resistance Is Not Associated with an Impaired Mitochondrial Function in Contracting Gastrocnemius Muscle of Goto-Kakizaki Diabetic Rats In Vivo,” PloS One, 10(6), p. e0129579. Available at: https://doi.org/10.1371/journal.pone.0129579.
Gondin, J., Vilmen, C., Cozzone, P.J., Bendahan, D. and Duhamel, G. (2014) “High-field (11.75T) multimodal MR imaging of exercising hindlimb mouse muscles using a non-invasive combined stimulation and force measurement device,” NMR in biomedicine, 27(8), pp. 870–879. Available at: https://doi.org/10.1002/nbm.3122.
Kazuya, Y., Tonson, A., Pecchi, E., Dalmasso, C., Vilmen, C., Fur, Y.L., Bernard, M., Bendahan, D. and Giannesini, B. (2014) “A single intake of capsiate improves mechanical performance and bioenergetics efficiency in contracting mouse skeletal muscle,” American Journal of Physiology. Endocrinology and Metabolism, 306(10), pp. E1110-1119. Available at: https://doi.org/10.1152/ajpendo.00520.2013.
Gineste, C., Ottenheijm, C., Le Fur, Y., Banzet, S., Pecchi, E., Vilmen, C., Cozzone, P.J., Koulmann, N., Hardeman, E.C., Bendahan, D. and Gondin, J. (2014) “Alterations at the cross-bridge level are associated with a paradoxical gain of muscle function in vivo in a mouse model of nemaline myopathy,” PloS One, 9(9), p. e109066. Available at: https://doi.org/10.1371/journal.pone.0109066.
Fouré, A., Nosaka, K., Wegrzyk, J., Duhamel, G., Le Troter, A., Boudinet, H., Mattei, J.-P., Vilmen, C., Jubeau, M., Bendahan, D. and Gondin, J. (2014) “Time course of central and peripheral alterations after isometric neuromuscular electrical stimulation-induced muscle damage,” PloS One, 9(9), p. e107298. Available at: https://doi.org/10.1371/journal.pone.0107298.
Giannesini, B., Vilmen, C., Amthor, H., Bernard, M. and Bendahan, D. (2013) “Lack of myostatin impairs mechanical performance and ATP cost of contraction in exercising mouse gastrocnemius muscle in vivo,” American journal of physiology. Endocrinology and metabolism, 305(1), pp. E33-40. Available at: https://doi.org/10.1152/ajpendo.00651.2012.
Gineste, C., De Winter, J.M., Kohl, C., Witt, C.C., Giannesini, B., Brohm, K., Le Fur, Y., Gretz, N., Vilmen, C., Pecchi, E., Jubeau, M., Cozzone, P.J., Stienen, G.J.M., Granzier, H., Labeit, S., Ottenheijm, C.A.C., Bendahan, D. and Gondin, J. (2013) “In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype,” Neuromuscular disorders: NMD, 23(4), pp. 357–369. Available at: https://doi.org/10.1016/j.nmd.2012.12.011.
Gineste, C., Le Fur, Y., Vilmen, C., Le Troter, A., Pecchi, E., Cozzone, P.J., Hardeman, E.C., Bendahan, D. and Gondin, J. (2013) “Combined MRI and (31)P-MRS Investigations of the ACTA1(H40Y) Mouse Model of Nemaline Myopathy Show Impaired Muscle Function and Altered Energy Metabolism,” PloS one, 8(4), p. e61517. Available at: https://doi.org/10.1371/journal.pone.0061517.
Gineste, C., Duhamel, G., Le Fur, Y., Vilmen, C., Cozzone, P.J., Nowak, K.J., Bendahan, D. and Gondin, J. (2013) “Multimodal MRI and (31)P-MRS Investigations of the ACTA1(Asp286Gly) Mouse Model of Nemaline Myopathy Provide Evidence of Impaired In Vivo Muscle Function, Altered Muscle Structure and Disturbed Energy Metabolism,” PloS one, 8(8), p. e72294. Available at: https://doi.org/10.1371/journal.pone.0072294.
Layec, G., Bringard, A., Yashiro, K., Le Fur, Y., Vilmen, C., Micallef, J.-P., Perrey, S., Cozzone, P.J. and Bendahan, D. (2012) “The slow components of phosphocreatine and pulmonary oxygen uptake can be dissociated during heavy exercise according to training status,” Experimental physiology, 97(8), pp. 955–969. Available at: https://doi.org/10.1113/expphysiol.2011.062927.
Chiche, J., Le Fur, Y., Vilmen, C., Frassineti, F., Daniel, L., Halestrap, A.P., Cozzone, P.J., Pouysségur, J. and Lutz, N.W. (2012) “In vivo pH in metabolic-defective Ras-transformed fibroblast tumors: key role of the monocarboxylate transporter, MCT4, for inducing an alkaline intracellular pH,” International journal of cancer. Journal international du cancer, 130(7), pp. 1511–1520. Available at: https://doi.org/10.1002/ijc.26125.
Gondin, J., Giannesini, B., Vilmen, C., Le Fur, Y., Cozzone, P.J. and Bendahan, D. (2011) “Effects of a single bout of isometric neuromuscular electrical stimulation on rat gastrocnemius muscle: a combined functional, biochemical and MRI investigation,” Journal of electromyography and kinesiology: official journal of the International Society of Electrophysiological Kinesiology, 21(3), pp. 525–532. Available at: https://doi.org/10.1016/j.jelekin.2011.01.006.
Layec, G., Bringard, A., Le Fur, Y., Vilmen, C., Micallef, J.-P., Perrey, S., Cozzone, P.J. and Bendahan, D. (2011) “Comparative determination of energy production rates and mitochondrial function using different 31P MRS quantitative methods in sedentary and trained subjects,” NMR in biomedicine, 24(4), pp. 425–438. Available at: https://doi.org/10.1002/nbm.1607.
Tonson, A., Ratel, S., Le Fur, Y., Vilmen, C., Cozzone, P.J. and Bendahan, D. (2010) “Muscle energetics changes throughout maturation: a quantitative 31P-MRS analysis,” Journal of applied physiology (Bethesda, Md.: 1985), 109(6), pp. 1769–1778. Available at: https://doi.org/10.1152/japplphysiol.01423.2009.
Giannesini, B., Vilmen, C., Le Fur, Y., Dalmasso, C., Cozzone, P.J. and Bendahan, D. (2010) “A strictly noninvasive MR setup dedicated to longitudinal studies of mechanical performance, bioenergetics, anatomy, and muscle recruitment in contracting mouse skeletal muscle,” Magnetic resonance in medicine: official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 64(1), pp. 262–270. Available at: https://doi.org/10.1002/mrm.22386.
Gondin, J., Giannesini, B., Vilmen, C., Dalmasso, C., le Fur, Y., Cozzone, P.J. and Bendahan, D. (2010) “Effects of stimulation frequency and pulse duration on fatigue and metabolic cost during a single bout of neuromuscular electrical stimulation,” Muscle & nerve, 41(5), pp. 667–678. Available at: https://doi.org/10.1002/mus.21572.
Layec, G., Bringard, A., Le Fur, Y., Vilmen, C., Micallef, J.-P., Perrey, S., Cozzone, P.J. and Bendahan, D. (2009) “Reproducibility assessment of metabolic variables characterizing muscle energetics in vivo: A 31P-MRS study,” Magnetic resonance in medicine: official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 62(4), pp. 840–854. Available at: https://doi.org/10.1002/mrm.22085.
Layec, G., Bringard, A., Le Fur, Y., Vilmen, C., Micallef, J.-P., Perrey, S., Cozzone, P.J. and Bendahan, D. (2009) “Effects of a prior high-intensity knee-extension exercise on muscle recruitment and energy cost: a combined local and global investigation in humans,” Experimental physiology, 94(6), pp. 704–719. Available at: https://doi.org/10.1113/expphysiol.2008.044651.
Layec, G., Bringard, A., Vilmen, C., Micallef, J.-P., Le Fur, Y., Perrey, S., Cozzone, P.J. and Bendahan, D. (2009) “Does oxidative capacity affect energy cost? An in vivo MR investigation of skeletal muscle energetics,” European journal of applied physiology, 106(2), pp. 229–242. Available at: https://doi.org/10.1007/s00421-009-1012-y.
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