VIOLA Angèle
Keywords
- preclinical MRI and MRS
- infectious diseases
- inflammation
- brain metabolism
- metabolic maturation of the brain
Research Projects
- Development of AI-based murine brain segmentation tools
- Metabolic maturation of the brain
- MRI and MRS of experimental cerebral malaria
- MRI of Blood Brain Barrier Disruption
- Structural and functional connectome: Impact of the circadian rhythm, biological sex, and age
- Validation of gadolinated and fluorinated theragnostic agents for cancer
Publications :
180164
VIOLA
1
harvard-cite-them-right-no-et-al
50
date
desc
year
2592
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Liu, X., Dhumal, D., Santofimia-Castaño, P., Liu, J., Casanova, M., Garcia-Muñoz, A.C., Perles-Barbacaru, T.-A., Elkihel, A., Zhang, W., Roussel, T., Galanakou, C., Wu, J., Zerva, E., Dusetti, N., Xia, Y., Liang, X.-J., Viola, A., Iovanna, J.L. and Peng, L. (2025) “Self-assembling dendrimer nanodrug formulations for decreased hERG-related toxicity and enhanced therapeutic efficacy,” Science Advances, 11(26), p. eadu9948. Available at: https://doi.org/10.1126/sciadv.adu9948.
Comino Garcia Muñoz, A., Marfouk, O., Michel, C.P., Varlet, I., Royer, E., Perles-Barbacaru, T.-A. and Viola, A. (2025) “Characterization of experimental cerebral malaria by volumetric MRI A comparative study across the sexes,” PloS One, 20(8), p. e0328693. Available at: https://doi.org/10.1371/journal.pone.0328693.
Comino Garcia-Munoz, A., Varlet, I., Grau, G.E., Perles-Barbacaru, T.-A. and Viola, A. (2024) “Contribution of Magnetic Resonance Imaging Studies to the Understanding of Cerebral Malaria Pathogenesis,” Pathogens (Basel, Switzerland), 13(12), p. 1042. Available at: https://doi.org/10.3390/pathogens13121042.
Lyu, Z., Ralahy, B., Perles-Barbacaru, T.-A., Ding, L., Jiang, Y., Lian, B., Roussel, T., Liu, Xi, Galanakou, C., Laurini, E., Tintaru, A., Giorgio, S., Pricl, S., Liu, Xiaoxuan, Bernard, M., Iovanna, J., Viola, A. and Peng, L. (2024) “Self-assembling dendrimer nanosystems for specific fluorine magnetic resonance imaging and effective theranostic treatment of tumors,” Proceedings of the National Academy of Sciences of the United States of America, 121(25), p. e2322403121. Available at: https://doi.org/10.1073/pnas.2322403121.
Lokossou, H.A., Rabuffo, G., Bernard, M., Bernard, C., Viola, A. and Perles-Barbacaru, T.-A. (2024) “Impact of the day/night cycle on functional connectome in ageing male and female mice,” NeuroImage, p. 120576. Available at: https://doi.org/10.1016/j.neuroimage.2024.120576.
Tessier, A., Ruze, A.J., Varlet, I., Laïb, E.M.H., Royer, E., Bernard, M., Viola, A. and Perles-Barbacaru, T.-A. (2024) “Quantitative MRI of Gd-DOTA Accumulation in the Mouse Brain After Intraperitoneal Administration: Validation by Mass Spectrometry,” Journal of Magnetic Resonance Imaging, 60(1), pp. 316–324. Available at: https://doi.org/10.1002/jmri.29034.
Ding, L., Lyu, Z., Perles-Barbacaru, T.-A., Huang, A.Y.-T., Lian, B., Jiang, Y., Roussel, T., Galanakou, C., Giorgio, S., Kao, C.-L., Liu, X., Iovanna, J., Bernard, M., Viola, A. and Peng, L. (2023) “Modular Self-Assembling Dendrimer Nanosystems for Magnetic Resonance And Multimodality Imaging of Tumors,” Advanced Materials (Deerfield Beach, Fla.), p. e2308262. Available at: https://doi.org/10.1002/adma.202308262.
Wachsmuth, L., Mensen, A., Barca, C., Wiart, M., Tristão-Pereira, C., Busato, A., Waiczies, S., Himmelreich, U., Millward, J.M., Reimann, H.M., Jelescu, I., Marzola, P., Pradier, B., Viola, A. and Faber, C. (2021) “Contribution of preclinical MRI to responsible animal research: living up to the 3R principle,” Magnetic Resonance Materials in Physics, Biology and Medicine, 34(4), pp. 469–474. Available at: https://doi.org/10.1007/s10334-021-00929-w.
Perles-Barbacaru, teodora-A., Viola, A., Helbich, T. and Ehret, V. (2021) “Nuclear magnetic resonance spectroscopy and imaging,” in Imaging Modalities for Biological and Preclinical Research: A Compendium, Volume 2, Parts II–IV: preclinical imaging, multimodality imaging and outlook, p. II.7.a-1-II.7.a-14. Available at: https://doi.org/10.1088/978-0-7503-3747-2 (Accessed: January 26, 2022).
Viola, A., le Fur, Y., Viout, P. and Girard, N. (2021) “MR Spectroscopy of Normal and Impaired Fetal Brain,” in G. Roberts and A. Watts (eds.) Encyclopedia of Biophysics. Berlin, Heidelberg: Springer, pp. 1–8. Available at: https://doi.org/10.1007/978-3-642-35943-9_10099-1.
Masi, B., Perles-Barbacaru, T.-A., Bernard, M. and Viola, A. (2020) “Clinical and Preclinical Imaging of Hepatosplenic Schistosomiasis,” Trends in Parasitology, 36(2), pp. 206–226. Available at: https://doi.org/10.1016/j.pt.2019.11.007.
Girard, N., Viout, P., Hak, J.-F., Confort-Gouny, S., LeFur, Y. and Viola, A. (2019) “Spectroscopie de la maturation cérébrale et de ses anomalies.,” Encyclopédie Médico-Chirurgicale EMC, 0(0), pp. 1–22.
Tournebize, R., Viola, A., Chapon, C. and Legrand, R. (2017) “L’imagerie in vivo en infectiologie,” BIOFUTUR le mensuel européen des biotechnologies, 386, pp. 42–43.
Laroche, M., Almeras, L., Pecchi, E., Bechah, Y., Raoult, D., Viola, A. and Parola, P. (2017) “MALDI-TOF MS as an innovative tool for detection of Plasmodium parasites in Anopheles mosquitoes,” Malaria Journal, 16(1), p. 5. Available at: https://doi.org/10.1186/s12936-016-1657-z.
Koob, M., Viola, A., Le Fur, Y., Viout, P., Ratiney, H., Confort-Gouny, S., Cozzone, P.J. and Girard, N. (2016) “Creatine, Glutamine plus Glutamate, and Macromolecules Are Decreased in the Central White Matter of Premature Neonates around Term,” PloS One, 11(8), p. e0160990. Available at: https://doi.org/10.1371/journal.pone.0160990.
Collignon, A., Perles-Barbacaru, A.T., Robert, S., Silvy, F., Martinez, E., Crenon, I., Germain, S., Garcia, S., Viola, A., Lombardo, D., Mas, E. and Béraud, E. (2015) “A pancreatic tumor-specific biomarker characterized in humans and mice as an immunogenic onco-glycoprotein is efficient in dendritic cell vaccination,” Oncotarget, 6(27), pp. 23462–23479.
Masi, B., Perles-Barbacaru, T.-A., Laprie, C., Dessein, H., Bernard, M., Dessein, A. and Viola, A. (2015) “In Vivo MRI Assessment of Hepatic and Splenic Disease in a Murine Model of Schistosomiasis [corrected],” PLoS neglected tropical diseases, 9(9), p. e0004036. Available at: https://doi.org/10.1371/journal.pntd.0004036.
Conductier, G., Viola, A., le Troter, A., Nahon, J.-L. and Guyon, A. (2013) “[Beating frequency of motile cilia lining the third cerebral ventricle is finely tuned by the hypothalamic peptide MCH],” Médecine sciences: M/S, 29(11), pp. 943–945. Available at: https://doi.org/10.1051/medsci/20132911004.
Conductier, G., Brau, F., Viola, A., Langlet, F., Ramkumar, N., Dehouck, B., Lemaire, T., Chapot, R., Lucas, L., Rovère, C., Maitre, P., Hosseiny, S., Petit-Paitel, A., Adamantidis, A., Lakaye, B., Risold, P.-Y., Prévot, V., Meste, O., Nahon, J.-L. and Guyon, A. (2013) “Melanin-concentrating hormone regulates beat frequency of ependymal cilia and ventricular volume,” Nature Neuroscience, 16(7), pp. 845–847. Available at: https://doi.org/10.1038/nn.3401.
Magalon, K., Zimmer, C., Cayre, M., Khaldi, J., Bourbon, C., Robles, I., Tardif, G., Viola, A., Pruss, R.M., Bordet, T. and Durbec, P. (2012) “Olesoxime accelerates myelination and promotes repair in models of demyelination,” Annals of neurology, 71(2), pp. 213–226. Available at: https://doi.org/10.1002/ana.22593.
Girard, N.-J., Dory-Lautrec, P., Anca Dediu, M., Chaumoitre, K., Confort-Gouny, S., Le Fur, Y. and Viola, A. (2012) “Spectroscopie de la maturation cérébrale et de ses anomalies,” EMC - Radiologie et imagerie médicale - Musculosquelettique - Neurologique - Maxillofaciale, 7(4), pp. 1–17. Available at: https://doi.org/10.1016/S1879-8551(12)50528-2.
Laigle, C., Confort-Gouny, S., Le Fur, Y., Cozzone, P.J. and Viola, A. (2012) “Deletion of TRAAK potassium channel affects brain metabolism and protects against ischemia,” PloS one, 7(12), p. e53266. Available at: https://doi.org/10.1371/journal.pone.0053266.
Saggu, R., Faille, D., Grau, G.E., Cozzone, P.J. and Viola, A. (2011) “In the eye of experimental cerebral malaria,” The American journal of pathology, 179(3), pp. 1104–1109. Available at: https://doi.org/10.1016/j.ajpath.2011.05.044.
Viola, A., Confort-Gouny, S., Schneider, J.F., Le Fur, Y., Viout, P., Chapon, F., Pineau, S., Cozzone, P.J. and Girard, N. (2011) “Is brain maturation comparable in fetuses and premature neonates at term equivalent age?,” AJNR. American journal of neuroradiology, 32(8), pp. 1451–1458. Available at: https://doi.org/10.3174/ajnr.A2555.
Girard, N., Confort−Gouny, S., Viola, A., Chapon, F., Ranjeva, J.-P., Pineau, S., Le Fur, Y. and Cozzone (2010) “Imagerie structurelle,” in Neurologie pédiatrique. 3e éd. Paris: Médecine-Sciences Flammarion (Pédiatrie).
Viola, A., Le Fur, Y., Laigle, C., Viout, P., Chabrol, B., Girard, N., Cozzone, P. and Confort-Gouny, S. (2010) “Exploration in vivo du neurométabolisme par spectroscopie de résonance magnétique,” in Neurologie Pédiatrique. 3e éd. Paris: Médecine-Sciences Flammarion (Pédiatrie).
Girard, N., Confort-Gouny, S., Schneider, J., Barberet, M., Chapon, F., Viola, A., Pineau, S., Combaz, X. and Cozzone, P. (2007) “MR imaging of brain maturation,” Journal of Neuroradiology. Journal De Neuroradiologie, 34(5), pp. 290–310. Available at: https://doi.org/10.1016/j.neurad.2007.07.007.
Schneider, J.F., Confort-Gouny, S., Viola, A., Le Fur, Y., Viout, P., Bennathan, M., Chapon, F., Figarella-Branger, D., Cozzone, P. and Girard, N. (2007) “Multiparametric differentiation of posterior fossa tumors in children using diffusion-weighted imaging and short echo-time 1H-MR spectroscopy,” Journal of magnetic resonance imaging: JMRI, 26(6), pp. 1390–1398. Available at: https://doi.org/10.1002/jmri.21185.
Girard, N., Confort-Gouny, S., Schneider, J., Chapon, F., Viola, A., Pineau, S., Combaz, X. and Cozzone, P. (2007) “Neuroimaging of neonatal encephalopathies,” Journal of Neuroradiology. Journal De Neuroradiologie, 34(3), pp. 167–182. Available at: https://doi.org/10.1016/j.neurad.2007.04.003.
Penet, M.-F., Kober, F., Confort-Gouny, S., Le Fur, Y., Dalmasso, C., Coltel, N., Liprandi, A., Gulian, J.-M., Grau, G.E., Cozzone, P.J. and Viola, A. (2007) “Magnetic resonance spectroscopy reveals an impaired brain metabolic profile in mice resistant to cerebral malaria infected with Plasmodium berghei ANKA,” The Journal of Biological Chemistry, 282(19), pp. 14505–14514. Available at: https://doi.org/10.1074/jbc.M608035200.
Lutz, N.W., Viola, A., Malikova, I., Confort-Gouny, S., Ranjeva, J.-P., Pelletier, J. and Cozzone, P.J. (2007) “A branched-chain organic acid linked to multiple sclerosis: first identification by NMR spectroscopy of CSF,” Biochemical and biophysical research communications, 354(1), pp. 160–164. Available at: https://doi.org/10.1016/j.bbrc.2006.12.169.
Schneider, J.F., Viola, A., Confort-Gouny, S., Ayunts, K., Le Fur, Y., Viout, P., Bennathan, M., Chapon, F., Figarella-Branger, D., Cozzone, P. and Girard, N. (2007) “Infratentorial pediatric brain tumors: the value of new imaging modalities,” Journal of neuroradiology. Journal de neuroradiologie, 34(1), pp. 49–58. Available at: https://doi.org/10.1016/j.neurad.2007.01.010.
Galanaud, D., Nicoli, F., Confort-Gouny, S., Le Fur, Y., Ranjeva, J.P., Viola, A., Girard, N. and Cozzone, P.J. (2007) “[Indications for cerebral MR proton spectroscopy in 2007],” Revue neurologique, 163(3), pp. 287–303.
Lutz, N.W., Viola, A., Malikova, I., Confort-Gouny, S., Audoin, B., Ranjeva, J.-P., Pelletier, J. and Cozzone, P.J. (2007) “Inflammatory multiple-sclerosis plaques generate characteristic metabolic profiles in cerebrospinal fluid,” PloS one, 2(7), p. e595. Available at: https://doi.org/10.1371/journal.pone.0000595.
Viola, A., Saywell, V., Villard, L., Cozzone, P.J. and Lutz, N.W. (2007) “Metabolic fingerprints of altered brain growth, osmoregulation and neurotransmission in a Rett syndrome model,” PloS one, 2(1), p. e157. Available at: https://doi.org/10.1371/journal.pone.0000157.
Beraud, E., Viola, A., Regaya, I., Confort-Gouny, S., Siaud, P., Ibarrola, D., Le Fur, Y., Barbaria, J., Pellissier, J.-F., Sabatier, J.-M., Medina, I. and Cozzone, P.J. (2006) “Block of neural Kv1.1 potassium channels for neuroinflammatory disease therapy,” Annals of neurology, 60(5), pp. 586–596. Available at: https://doi.org/10.1002/ana.21007.
Girard, N., Gouny, S.C., Viola, A., Le Fur, Y., Viout, P., Chaumoitre, K., D’Ercole, C., Gire, C., Figarella-Branger, D. and Cozzone, P.J. (2006) “Assessment of normal fetal brain maturation in utero by proton magnetic resonance spectroscopy,” Magnetic resonance in medicine: official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 56(4), pp. 768–775. Available at: https://doi.org/10.1002/mrm.21017.
Penet, M.-F., Laigle, C., Fur, Y.L., Confort-Gouny, S., Heurteaux, C., Cozzone, P.J. and Viola, A. (2006) “In vivo characterization of brain morphometric and metabolic endophenotypes in three inbred strains of mice using magnetic resonance techniques,” Behavior genetics, 36(5), pp. 732–744. Available at: https://doi.org/10.1007/s10519-006-9077-4.
Girard, N., Chaumoitre, K., Confort-Gouny, S., Viola, A. and Levrier, O. (2006) “Magnetic resonance imaging and the detection of fetal brain anomalies, injury, and physiologic adaptations,” Current opinion in obstetrics & gynecology, 18(2), pp. 164–176. Available at: https://doi.org/10.1097/01.gco.0000193002.58158.07.
Saywell, V., Viola, A., Confort-Gouny, S., Le Fur, Y., Villard, L. and Cozzone, P.J. (2006) “Brain magnetic resonance study of Mecp2 deletion effects on anatomy and metabolism,” Biochemical and biophysical research communications, 340(3), pp. 776–783. Available at: https://doi.org/10.1016/j.bbrc.2005.12.080.
Girard, N., Fogliarini, C., Viola, A., Confort-Gouny, S., Fur, Y.L., Viout, P., Chapon, F., Levrier, O. and Cozzone, P. (2006) “MRS of normal and impaired fetal brain development,” European journal of radiology, 57(2), pp. 217–225. Available at: https://doi.org/10.1016/j.ejrad.2005.11.021.
Penet, M.-F., Viola, A., Confort-Gouny, S., Le Fur, Y., Duhamel, G., Kober, F., Ibarrola, D., Izquierdo, M., Coltel, N., Gharib, B., Grau, G.E. and Cozzone, P.J. (2005) “Imaging experimental cerebral malaria in vivo: significant role of ischemic brain edema,” The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 25(32), pp. 7352–7358. Available at: https://doi.org/10.1523/JNEUROSCI.1002-05.2005.
Viola, A., Nicoli, F., Denis, B., Confort-Gouny, S., Le Fur, Y., Ranjeva, J.-P., Viout, P. and Cozzone, P.J. (2004) “High cerebral scyllo-inositol: a new marker of brain metabolism disturbances induced by chronic alcoholism,” Magma (New York, N.Y.), 17(1), pp. 47–61. Available at: https://doi.org/10.1007/s10334-004-0044-x.
Brunel, H., Girard, N., Confort-Gouny, S., Viola, A., Chaumoitre, K., D’ercole, C., Figarella-Branger, D., Raybaud, C., Cozzone, P. and Panuel, M. (2004) “Fetal brain injury,” Journal of Neuroradiology. Journal De Neuroradiologie, 31(2), pp. 123–137.
Viola, A., Chabrol, B., Nicoli, F., Confort-Gouny, S., Viout, P. and Cozzone, P.J. (2002) “Magnetic resonance spectroscopy study of glycine pathways in nonketotic hyperglycinemia,” Pediatric research, 52(2), pp. 292–300. Available at: https://doi.org/10.1203/00006450-200208000-00024.
Viola, A., Confort-Gouny, S., Ranjeva, J.-P., Chabrol, B., Raybaud, C., Vintila, F. and Cozzone, P.J. (2002) “MR imaging and MR spectroscopy in rhizomelic chondrodysplasia punctata,” AJNR. American journal of neuroradiology, 23(3), pp. 480–483.
Viola, A., Nicoli, F., Confort-Gouny, S., Le Fur, Y., Ranjeva, J.P. and Cozzone, P.J. (2001) “[Applications of magnetic resonance spectrometry (MRS) in the study of metabolic disturbances affecting the brain in alcoholism],” Pathologie-biologie, 49(9), pp. 718–725.
Viola, A., Nicoli, F., Confort-Gouny, S., Le Fur, Y., Ranjeva, J.-P. and Cozzone, P.J. (2001) “Applications de la spectrométrie de résonance magnétique (SRM) à l’étude des perturbations métaboliques affectant le cerveau au cours de l’alcoolisme,” Pathologie Biologie, 49(9), pp. 718–725. Available at: https://doi.org/10.1016/S0369-8114(01)00233-4.