Mchinda Samira

CNS

Post-doctoral fellow / AMU

Post-doctoral Fellow (PhD)

Detailed Activities

My work consists in post-processing multiparametric MRI data obtained from healthy subjects and subjects with demyelinating diseases (ALS, MS, NMO).

Keywords

Image Processing
Multiple Sclerosis
Quantitative MRI

Spinal cord MRI
Multiple Sclerosis
Amyotrophic Lateral Sclerosis
Neuromyelitis Optica

Research Projects

Publications :

180164 Mchinda 1 harvard-cite-them-right-no-et-al 50 date desc year 4801 https://crmbm.univ-amu.fr/wp-content/plugins/zotpress/

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Farah, K., Mchinda, S., Pini, L., Baucher, G., Roche, P.-H., Fuentes, S. and Callot, V. (2025) “T1 mapping using MP2RAGE in degenerative cervical myelopathy: a longitudinal study,” European Spine Journal [Preprint]. Available at: https://doi.org/10.1007/s00586-025-08652-z.

Soustelle, L., Mchinda, S., Hertanu, A., Gherib, S., Pini, L., Guye, M., Ranjeva, J.-P., Varma, G., Alsop, D.C., Pelletier, J., Girard, O.M. and Duhamel, G. (2024) “Inhomogeneous magnetization transfer (ihMT) imaging reveals variable recovery profiles of active MS lesions according to size and localization,” Imaging Neuroscience (Cambridge, Mass.), 2, p. imag–2–00235. Available at: https://doi.org/10.1162/imag_a_00235.

Testud, B., Fabiani, N., Demortière, S., Mchinda, S., Medina, N.L., Pelletier, J., Guye, M., Audoin, B., Stellmann, J.P. and Callot, V. (2023) “Contribution of the MP2RAGE 7T Sequence in MS Lesions of the Cervical Spinal Cord,” AJNR. American journal of neuroradiology, 44(9), pp. 1101–1107. Available at: https://doi.org/10.3174/ajnr.A7964.

Soustelle, L., Troalen, T., Hertanu, A., Mchinda, S., Ranjeva, J.-P., Guye, M., Varma, G., Alsop, D.C., Duhamel, G. and Girard, O.M. (2022) “A strategy to reduce the sensitivity of inhomogeneous magnetization transfer (ihMT) imaging to radiofrequency transmit field variations at 3 T,” Magnetic Resonance in Medicine, 87(3), pp. 1346–1359. Available at: https://doi.org/10.1002/mrm.29055.

Carvalho, V.N.D., Hertanu, A., Grélard, A., Mchinda, S., Soustelle, L., Loquet, A., Dufourc, E.J., Varma, G., Alsop, D.C., Thureau, P., Girard, O.M. and Duhamel, G. (2020) “MRI assessment of multiple dipolar relaxation time (T1D) components in biological tissues interpreted with a generalized inhomogeneous magnetization transfer (ihMT) model,” Journal of Magnetic Resonance (San Diego, Calif.: 1997), 311, p. 106668. Available at: https://doi.org/10.1016/j.jmr.2019.106668.

Duhamel, G., Prevost, V.H., Cayre, M., Hertanu, A., Mchinda, S., Carvalho, V.N., Varma, G., Durbec, P., Alsop, D.C. and Girard, O.M. (2019) “Validating the sensitivity of inhomogeneous magnetization transfer (ihMT) MRI to myelin with fluorescence microscopy,” NeuroImage, 199, pp. 289–303. Available at: https://doi.org/10.1016/j.neuroimage.2019.05.061.

Varma, G., Girard, O.M., Mchinda, S., Prevost, V.H., Grant, A.K., Duhamel, G. and Alsop, D.C. (2018) “Low duty-cycle pulsed irradiation reduces magnetization transfer and increases the inhomogeneous magnetization transfer effect,” Journal of Magnetic Resonance (San Diego, Calif.: 1997), 296, pp. 60–71. Available at: https://doi.org/10.1016/j.jmr.2018.08.004.

Mchinda, S., Varma, G., Prevost, V.H., Le Troter, A., Rapacchi, S., Guye, M., Pelletier, J., Ranjeva, J.-P., Alsop, D.C., Duhamel, G. and Girard, O.M. (2018) “Whole brain inhomogeneous magnetization transfer (ihMT) imaging: Sensitivity enhancement within a steady-state gradient echo sequence,” Magnetic Resonance in Medicine, 79(5), pp. 2607–2619. Available at: https://doi.org/10.1002/mrm.26907.

Van Obberghen, E., Mchinda, S., le Troter, A., Prevost, V.H., Viout, P., Guye, M., Varma, G., Alsop, D.C., Ranjeva, J.-P., Pelletier, J., Girard, O. and Duhamel, G. (2018) “Evaluation of the Sensitivity of Inhomogeneous Magnetization Transfer (ihMT) MRI for Multiple Sclerosis,” AJNR. American journal of neuroradiology, 39(4), pp. 634–641. Available at: https://doi.org/10.3174/ajnr.A5563.

Prevost, V.H., Girard, O.M., Mchinda, S., Varma, G., Alsop, D.C. and Duhamel, G. (2017) “Optimization of inhomogeneous magnetization transfer (ihMT) MRI contrast for preclinical studies using dipolar relaxation time (T1D) filtering,” NMR in Biomedicine, 30(6). Available at: https://doi.org/10.1002/nbm.3706.

MCHINDA Samira