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Matias, A.A., Serviente, C.F., Decker, S.T., Erol, M.E., Giuriato, G., Le Fur, Y., Nagarajan, R., Bendahan, D. and Layec, G. (2024) “Repeatability of alkaline inorganic phosphate quantification in the skeletal muscle using 31P-magnetic resonance spectroscopy at 3 T,” NMR in biomedicine, p. e5255. Available at: https://doi.org/10.1002/nbm.5255.
Michel, C.P., Messonnier, L.A., Giannesini, B., Vilmen, C., Sourdon, J., Le Fur, Y. and Bendahan, D. (2024) “Endurance training and hydroxyurea have synergistic effects on muscle function and energetics in sickle cell disease mice,” Blood Cells, Molecules & Diseases, 107, p. 102853. Available at: https://doi.org/10.1016/j.bcmd.2024.102853.
Salin, P., Melon, C., Chassain, C., Gubellini, P., Pages, G., Pereira, B., Le Fur, Y., Durif, F. and Kerkerian-Le Goff, L. (2024) “Interhemispheric reactivity of the subthalamic nucleus sustains progressive dopamine neuron loss in asymmetrical parkinsonism,” Neurobiology of Disease, 191, p. 106398. Available at: https://doi.org/10.1016/j.nbd.2023.106398.
Kober, F., Caus, T., Riberi, A., Le Fur, Y. and Bernard, M. (2024) “Time Course of High-Energy Phosphate Depletion During Cold Storage of Human Heart Grafts Using the Celsior Solution,” Transplant International: Official Journal of the European Society for Organ Transplantation, 37, p. 12994. Available at: https://doi.org/10.3389/ti.2024.12994.
Michel, C.P., Bendahan, D., Giannesini, B., Vilmen, C., Le Fur, Y. and Messonnier, L.A. (2023) “Effects of hydroxyurea on skeletal muscle energetics and force production in a sickle cell disease murine model,” Journal of Applied Physiology, 134(2), pp. 415–425. Available at: https://doi.org/10.1152/japplphysiol.00333.2022.
Nassar, J., Trabelsi, A., Amer, R., Le Fur, Y., Attarian, S., Radunsky, D., Blumenfeld-Katzir, T., Greenspan, H., Bendahan, D. and Ben-Eliezer, N. (2023) “Estimation of subvoxel fat infiltration in neurodegenerative muscle disorders using quantitative multi-T2 analysis,” NMR in Biomedicine, 36(9), p. e4947. Available at: https://doi.org/10.1002/nbm.4947.
Hostin, M.-A., Ogier, A.C., Michel, C.P., Le Fur, Y., Guye, M., Attarian, S., Fortanier, E., Bellemare, M.-E. and Bendahan, D. (2023) “The Impact of Fatty Infiltration on MRI Segmentation of Lower Limb Muscles in Neuromuscular Diseases: A Comparative Study of Deep Learning Approaches,” Journal of Magnetic Resonance Imaging, 58(6), pp. 1826–1835. Available at: https://doi.org/10.1002/jmri.28708.
Roussel, T., Le Fur, Y., Guye, M., Viout, P., Ranjeva, J.-P. and Callot, V. (2022) “Respiratory-triggered quantitative MR spectroscopy of the human cervical spinal cord at 7 T,” Magnetic Resonance in Medicine, 87(6), pp. 2600–2612. Available at: https://doi.org/10.1002/mrm.29182.
Michel, C.P., Messonnier, L.A., Giannesini, B., Chatel, B., Vilmen, C., Le Fur, Y. and Bendahan, D. (2022) “Effects of Hydroxyurea on Skeletal Muscle Energetics and Function in a Mildly Anemic Mouse Model,” Frontiers in Physiology, 13, p. 915640. Available at: https://doi.org/10.3389/fphys.2022.915640.
Viola, A., le Fur, Y., Viout, P. and Girard, N. (2021) “MR Spectroscopy of Normal and Impaired Fetal Brain,” in G. Roberts and A. Watts (eds.) Encyclopedia of Biophysics. Berlin, Heidelberg: Springer, pp. 1–8. Available at: https://doi.org/10.1007/978-3-642-35943-9_10099-1.
Berg, O.K., Kwon, O.S., Hureau, T.J., Clifton, H.L., Thurston, T.S., Le Fur, Y., Jeong, E.-K., Trinity, J.D., Richardson, R.S., Wang, E. and Layec, G. (2020) “Skeletal Muscle Mitochondrial Adaptations to Maximal Strength Training in Older Adults,” The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 75(12), pp. 2269–2277. Available at: https://doi.org/10.1093/gerona/glaa082.
Kammoun, M., Piquereau, J., Nadal-Desbarats, L., Même, S., Beuvin, M., Bonne, G., Veksler, V., Le Fur, Y., Pouletaut, P., Même, W., Szeremeta, F., Constans, J.-M., Bruinsma, E.S., Nelson Holte, M.H., Najafova, Z., Johnsen, S.A., Subramaniam, M., Hawse, J.R. and Bensamoun, S.F. (2019) “Novel Role of Tieg1 in Muscle Metabolism and Mitochondrial Oxidative Capacities,” Acta Physiologica (Oxford, England), p. e13394. Available at: https://doi.org/10.1111/apha.13394.
Donadieu, M., Le Fur, Y., Maarouf, A., Gherib, S., Ridley, B., Pini, L., Rapacchi, S., Confort-Gouny, S., Guye, M., Schad, L.R., Maudsley, A.A., Pelletier, J., Audoin, B., Zaaraoui, W. and Ranjeva, J.-P. (2019) “Metabolic counterparts of sodium accumulation in multiple sclerosis: A whole brain 23Na-MRI and fast 1H-MRSI study,” Multiple Sclerosis (Houndmills, Basingstoke, England), 25(1), pp. 39–47. Available at: https://doi.org/10.1177/1352458517736146.
Berg, O.K., Kwon, O.S., Hureau, T.J., Clifton, H.L., Thurston, T., Le Fur, Y., Jeong, E.-K., Amann, M., Richardson, R.S., Trinity, J.D., Wang, E. and Layec, G. (2018) “Maximal strength training increases muscle force generating capacity and the anaerobic ATP synthesis flux without altering the cost of contraction in elderly,” Experimental Gerontology, 111, pp. 154–161. Available at: https://doi.org/10.1016/j.exger.2018.07.013.
Hart, C.R., Layec, G., Trinity, J.D., Le Fur, Y., Gifford, J.R., Clifton, H.L. and Richardson, R.S. (2018) “Oxygen availability and skeletal muscle oxidative capacity in patients with peripheral artery disease: implications from in vivo and in vitro assessments,” American Journal of Physiology-Heart and Circulatory Physiology, 315(4), pp. H897–H909. Available at: https://doi.org/10.1152/ajpheart.00641.2017.
Diaz-Manera, J., Fernandez-Torron, R., LLauger, J., James, M.K., Mayhew, A., Smith, F.E., Moore, U.R., Blamire, A.M., Carlier, P.G., Rufibach, L., Mittal, P., Eagle, M., Jacobs, M., Hodgson, T., Wallace, D., Ward, L., Smith, M., Stramare, R., Rampado, A., Sato, N., Tamaru, T., Harwick, B., Rico Gala, S., Turk, S., Coppenrath, E.M., Foster, G., Bendahan, D., Le Fur, Y., Fricke, S.T., Otero, H., Foster, S.L., Peduto, A., Sawyer, A.M., Hilsden, H., Lochmuller, H., Grieben, U., Spuler, S., Tesi Rocha, C., Day, J.W., Jones, K.J., Bharucha-Goebel, D.X., Salort-Campana, E., Harms, M., Pestronk, A., Krause, S., Schreiber-Katz, O., Walter, M.C., Paradas, C., Hogrel, J.-Y., Stojkovic, T., Takeda, S., Mori-Yoshimura, M., Bravver, E., Sparks, S., Bello, L., Semplicini, C., Pegoraro, E., Mendell, J.R., Bushby, K., Straub, V. and Jain COS Consortium (2018) “Muscle MRI in patients with dysferlinopathy: pattern recognition and implications for clinical trials,” Journal of Neurology, Neurosurgery, and Psychiatry, 89(10), pp. 1071–1081. Available at: https://doi.org/10.1136/jnnp-2017-317488.
Layec, G., Trinity, J.D., Hart, C.R., Le Fur, Y., Zhao, J., Reese, V., Jeong, E.-K. and Richardson, R.S. (2018) “Impaired Muscle Efficiency but Preserved Peripheral Hemodynamics and Mitochondrial Function With Advancing Age: Evidence From Exercise in the Young, Old, and Oldest-Old,” The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 73(10), pp. 1303–1312. Available at: https://doi.org/10.1093/gerona/gly050.
Layec, G., Hart, C.R., Trinity, J.D., Kwon, O.-S., Rossman, M.J., Broxterman, R.M., Le Fur, Y., Jeong, E.-K. and Richardson, R.S. (2017) “Oxygen delivery and the restoration of the muscle energetic balance following exercise: implications for delayed muscle recovery in patients with COPD,” American Journal of Physiology-Endocrinology and Metabolism, 313(1), pp. E94–E104. Available at: https://doi.org/10.1152/ajpendo.00462.2016.
Chatel, B., Bendahan, D., Hourdé, C., Pellerin, L., Lengacher, S., Magistretti, P., Le Fur, Y., Vilmen, C., Bernard, M. and Messonnier, L.A. (2017) “Role of MCT1 and CAII in skeletal muscle pH homeostasis, energetics, and function: in vivo insights from MCT1 haploinsufficient mice,” FASEB journal: official publication of the Federation of American Societies for Experimental Biology, 31(6), pp. 2562–2575. Available at: https://doi.org/10.1096/fj.201601259R.
Chatel, B., Hourdé, C., Gondin, J., Fouré, A., Le Fur, Y., Vilmen, C., Bernard, M., Messonnier, L.A. and Bendahan, D. (2017) “Impaired muscle force production and higher fatigability in a mouse model of sickle cell disease,” Blood Cells, Molecules & Diseases, 63, pp. 37–44. Available at: https://doi.org/10.1016/j.bcmd.2017.01.004.
Layec, G., Trinity, J.D., Hart, C.R., Le Fur, Y., Sorensen, J.R., Jeong, E.-K. and Richardson, R.S. (2016) “Evidence of a metabolic reserve in the skeletal muscle of elderly people,” Aging, 9(1), pp. 52–67. Available at: https://doi.org/10.18632/aging.101079.
Béchir, N., Pecchi, E., Vilmen, C., Le Fur, Y., Amthor, H., Bernard, M., Bendahan, D. and Giannesini, B. (2016) “ActRIIB blockade increases force-generating capacity and preserves energy supply in exercising mdx mouse muscle in vivo,” FASEB journal: official publication of the Federation of American Societies for Experimental Biology, 30(10), pp. 3551–3562. Available at: https://doi.org/10.1096/fj.201600271RR.
Donadieu, M., Le Fur, Y., Lecocq, A., Maudsley, A.A., Gherib, S., Soulier, E., Confort-Gouny, S., Pariollaud, F., Ranjeva, M.-P., Pelletier, J., Guye, M., Zaaraoui, W., Audoin, B. and Ranjeva, J.-P. (2016) “Metabolic voxel-based analysis of the complete human brain using fast 3D-MRSI: Proof of concept in multiple sclerosis,” Journal of magnetic resonance imaging: JMRI, 44(2), pp. 411–419. Available at: https://doi.org/10.1002/jmri.25139.
Martin, A., Grosprêtre, S., Vilmen, C., Guye, M., Mattei, J.-P., LE Fur, Y., Bendahan, D. and Gondin, J. (2016) “The Etiology of Muscle Fatigue Differs between Two Electrical Stimulation Protocols,” Medicine and Science in Sports and Exercise, 48(8), pp. 1474–1484. Available at: https://doi.org/10.1249/MSS.0000000000000930.
Donadieu, M., Le Fur, Y., Confort-Gouny, S., Le Troter, A., Guye, M. and Ranjeva, J.-P. (2016) “Evidencing different neurochemical profiles between thalamic nuclei using high resolution 2D-PRESS semi-LASER (1)H-MRSI at 7 T,” Magma (New York, N.Y.), 29(3), pp. 491–501. Available at: https://doi.org/10.1007/s10334-016-0556-1.
Layec, G., Bringard, A., LE Fur, Y., Micallef, J.-P., Vilmen, C., Perrey, S., Cozzone, P.J. and Bendahan, D. (2016) “Mitochondrial Coupling and Contractile Efficiency in Humans with High and Low V˙O2peaks,” Medicine and Science in Sports and Exercise, 48(5), pp. 811–821. Available at: https://doi.org/10.1249/MSS.0000000000000858.
Béchir, N., Pecchi, É., Relizani, K., Vilmen, C., Le Fur, Y., Bernard, M., Amthor, H., Bendahan, D. and Giannesini, B. (2016) “Mitochondrial impairment induced by postnatal ActRIIB blockade does not alter function and energy status in exercising mouse glycolytic muscle in vivo,” American Journal of Physiology. Endocrinology and Metabolism, 310(7), pp. E539-549. Available at: https://doi.org/10.1152/ajpendo.00370.2015.
Sdika, M., Tonson, A., Le Fur, Y., Cozzone, P.J. and Bendahan, D. (2016) “Multi-atlas-based fully automatic segmentation of individual muscles in rat leg,” Magma (New York, N.Y.), 29(2), pp. 223–235. Available at: https://doi.org/10.1007/s10334-015-0511-6.
Fouré, A., Nosaka, K., Gastaldi, M., Mattei, J.-P., Boudinet, H., Guye, M., Vilmen, C., Le Fur, Y., Bendahan, D. and Gondin, J. (2016) “Effects of branched-chain amino acids supplementation on both plasma amino acids concentration and muscle energetics changes resulting from muscle damage: A randomized placebo controlled trial,” Clinical Nutrition (Edinburgh, Scotland), 35(1), pp. 83–94. Available at: https://doi.org/10.1016/j.clnu.2015.03.014.
Layec, G., Gifford, J.R., Trinity, J.D., Hart, C.R., Garten, R.S., Park, S.Y., Le Fur, Y., Jeong, E.-K. and Richardson, R.S. (2016) “Accuracy and precision of quantitative 31P-MRS measurements of human skeletal muscle mitochondrial function,” American Journal of Physiology. Endocrinology and Metabolism, 311(2), pp. E358-366. Available at: https://doi.org/10.1152/ajpendo.00028.2016.
Koob, M., Viola, A., Le Fur, Y., Viout, P., Ratiney, H., Confort-Gouny, S., Cozzone, P.J. and Girard, N. (2016) “Creatine, Glutamine plus Glutamate, and Macromolecules Are Decreased in the Central White Matter of Premature Neonates around Term,” PloS One, 11(8), p. e0160990. Available at: https://doi.org/10.1371/journal.pone.0160990.
Martel, D., Tse Ve Koon, K., Le Fur, Y. and Ratiney, H. (2015) “Localized 2D COSY sequences: Method and experimental evaluation for a whole metabolite quantification approach,” Journal of Magnetic Resonance (San Diego, Calif.: 1997), 260, pp. 98–108. Available at: https://doi.org/10.1016/j.jmr.2015.09.002.
Varoquaux, A., le Fur, Y., Imperiale, A., Reyre, A., Montava, M., Fakhry, N., Namer, I.-J., Moulin, G., Pacak, K., Guye, M. and Taïeb, D. (2015) “Magnetic resonance spectroscopy of paragangliomas: new insights into in vivo metabolomics,” Endocrine-Related Cancer, 22(4), pp. M1-8. Available at: https://doi.org/10.1530/ERC-15-0246.
Lecocq, A., Le Fur, Y., Maudsley, A.A., Le Troter, A., Sheriff, S., Sabati, M., Donadieu, M., Confort-Gouny, S., Cozzone, P.J., Guye, M. and Ranjeva, J.-P. (2015) “Whole-brain quantitative mapping of metabolites using short echo three-dimensional proton MRSI,” Journal of magnetic resonance imaging: JMRI, 42(2), pp. 280–289. Available at: https://doi.org/10.1002/jmri.24809.
Fouré, A., Wegrzyk, J., LE Fur, Y., Mattei, J.-P., Boudinet, H., Vilmen, C., Bendahan, D. and Gondin, J. (2015) “Impaired mitochondrial function and reduced energy cost as a result of muscle damage,” Medicine and Science in Sports and Exercise, 47(6), pp. 1135–1144. Available at: https://doi.org/10.1249/MSS.0000000000000523.
Jubeau, M., LE Fur, Y., Duhamel, G., Wegrzyk, J., Confort-Gouny, S., Vilmen, C., Cozzone, P.J., Mattei, J.P., Bendahan, D. and Gondin, J. (2015) “Localized metabolic and t2 changes induced by voluntary and evoked contractions,” Medicine and Science in Sports and Exercise, 47(5), pp. 921–930. Available at: https://doi.org/10.1249/MSS.0000000000000491.
Layec, G., Bringard, A., Le Fur, Y., Micallef, J.-P., Vilmen, C., Perrey, S., Cozzone, P.J. and Bendahan, D. (2015) “Opposite effects of hyperoxia on mitochondrial and contractile efficiency in human quadriceps muscles,” American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 308(8), pp. R724-733. Available at: https://doi.org/10.1152/ajpregu.00461.2014.
Lecocq, A., Le Fur, Y., Amadon, A., Vignaud, A., Cozzone, P.J., Guye, M. and Ranjeva, J.-P. (2015) “Fast water concentration mapping to normalize (1)H MR spectroscopic imaging,” Magma (New York, N.Y.), 28(1), pp. 87–100. Available at: https://doi.org/10.1007/s10334-014-0451-6.
Le Fur, Y. and Cozzone, P.J. (2015) “Hemi-spectrum substitution after water signal fitting (HESWAF): an improvement of the modulus post-processing of MR spectra,” Magma (New York, N.Y.), 28(1), pp. 67–85. Available at: https://doi.org/10.1007/s10334-014-0444-5.