Center for Magnetic Resonance in Biology and Medicine
CRMBM-CEMEREM UMR 7339

HAAST Roy

By Stanislas Rapacchi on 14 January 2022

HAAST Roy

roy.HAAST@univ-amu.fr

CNS

Post-doctoral Fellow (PhD)

at AMU

Detailed Activities

My research interests are centred around in vivo characterization of neurobiological changes in clinical populations by development, optimization, and standardization of 7T MRI imaging and analysis tools. My current and previous research have directed my interests towards the intersection of (1) medical biology, and (2) novel neuroimaging and (3) imaging data analysis technologies. I believe that this ‘triad’ of research interests will significantly impact the diagnosis of disease and patient’s well-being by combining the advantages that come with state-of-the-art MRI technologies with novel analysis methods. This allows robust and precise detection of structural and functional changes towards precision medicine.

At CRMBM and as part of the epilepsy research group headed by Maxime Guye, I am exploring subcortical correlates of focal epilepsy by establishing a high-resolution MRI analytical framework involving connectomic and quantitative brain mapping methods. I anticipate that characterizing the subcortical changes within, as well as differences between epileptic patients will (1) help understand disease heterogeneity and the variable treatment efficacy, and (2) facilitate more personalized treatment. I am supported by a Marie Skłodowska-Curie Individual Fellowship (January 2023 – December 2024).

Keywords

  • Epilepsy
  • Quantitative MRI
  • Ultra-high field MRI
  • Image Processing
  • Clinical Neuroscience
  • Personalized Medicine

General Information

International collaborators:
I have on-going (inter)national collaborations with researchers in Canada (Ali Khan, Kamil Uludag) and Netherlands (Benedikt Poser, Jaap Jansen) as well as though the international Thalamus Nuclei Neuroimaging Group (https://thalamicsegmentation.github.io/)

Publications:
Please see my Google Scholar profile for an up-to-date list of my publications (https://scholar.google.com/citations?hl=en&user=ggP5dsIAAAAJ)

Research Projects

Publications :

180164 HAAST 1 harvard-cite-them-right-no-et-al 50 date desc year 5021 https://crmbm.univ-amu.fr/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22IRDNCDL2%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Gauer%20et%20al.%22%2C%22parsedDate%22%3A%222025-11-05%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BGauer%2C%20L.%2C%20Haast%2C%20R.A.M.%2C%20Azilinon%2C%20M.%2C%20El%20Mendili%2C%20M.M.%2C%20Makhalova%2C%20J.%2C%20Dary%2C%20H.%2C%20Dinkelacker%2C%20V.%2C%20Ridley%2C%20B.%2C%20Ranjeva%2C%20J.-P.%2C%20Zaaraoui%2C%20W.%2C%20Bartolomei%2C%20F.%20and%20Guye%2C%20M.%20%282025%29%20%26%23x201C%3BInvestigating%20sodium%20homeostasis%20of%20structural%20brain%20hubs%20in%20focal%20epilepsy%20using%207%20T%20MRI%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BBrain%3A%20A%20Journal%20of%20Neurology%26lt%3B%5C%2Fi%26gt%3B%2C%20p.%20awaf409.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fbrain%5C%2Fawaf409%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fbrain%5C%2Fawaf409%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Investigating%20sodium%20homeostasis%20of%20structural%20brain%20hubs%20in%20focal%20epilepsy%20using%207%20T%20MRI%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lucas%22%2C%22lastName%22%3A%22Gauer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Roy%20A.%20M.%22%2C%22lastName%22%3A%22Haast%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mikhael%22%2C%22lastName%22%3A%22Azilinon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mohamed%20Mounir%22%2C%22lastName%22%3A%22El%20Mendili%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Makhalova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hugo%22%2C%22lastName%22%3A%22Dary%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vera%22%2C%22lastName%22%3A%22Dinkelacker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ben%22%2C%22lastName%22%3A%22Ridley%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Philippe%22%2C%22lastName%22%3A%22Ranjeva%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wafaa%22%2C%22lastName%22%3A%22Zaaraoui%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabrice%22%2C%22lastName%22%3A%22Bartolomei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maxime%22%2C%22lastName%22%3A%22Guye%22%7D%5D%2C%22abstractNote%22%3A%22Besides%20their%20crucial%20role%20in%20cerebral%20connectivity%2C%20brain%20hubs%20are%20regions%20vulnerable%20to%20the%20energy%20deficit%20associated%20with%20various%20brain%20disorders.%20Changes%20in%20sodium%20homeostasis%20of%20cortical%20regions%20have%20been%20observed%20in%20focal%20epilepsy%20and%20may%20reflect%20energy%20failure.%20We%20investigated%20whether%20nodal%20structural%20connectivity%20is%20differently%20affected%20within%20the%20hub%20and%20non-hub%20regions%20by%20ionic%20perturbations%20associated%20with%20focal%20epilepsy.%20Our%20hypothesis%20was%20that%20the%20metabolic%20demands%20of%20hub%20regions%20may%20be%20associated%20with%20a%20distinct%20ionic%20profile%20detectable%20by%20sodium%20MRI%20and%20that%20this%20profile%20is%20altered%20in%20focal%20epilepsy.%20We%20included%2039%20patients%20with%20drug-resistant%20focal%20epilepsy%20and%2021%20age-%20and%20gender-matched%20healthy%20controls.%20Anatomical%2C%20diffusion-weighted%2C%20and%20sodium%20imaging%20was%20performed%20using%20a%207%20Tesla%20MRI%20scanner.%20Patients%20underwent%20pre-surgical%20work-up%2C%20including%20stereo-electroencephalographic%20recordings%20for%20defining%20the%20epileptogenic%20regions.%20Anatomical%20parcellation%20and%20multimodal%20coregistration%20allowed%20the%20use%20of%20parcels%20as%20nodes%20of%20whole-brain%20structural%20connectomes%2C%20linking%20structural%20connectivity%20measures%20to%20epileptogenicity%20and%20sodium%20parameters.%20Sodium%20parameters%20in%20patients%20were%20z-scored%20concerning%20homologous%20parcels%20in%20controls%20to%20allow%20comparison%20across%20regions%20of%20interest.%20Hub%20regions%20had%20higher%20total%20sodium%20concentration%20%28TSC%29%20than%20non-hub%20regions%20in%20both%20patients%20and%20controls%2C%20and%20this%20difference%20was%20not%20observed%20for%20sodium%20signal%20fraction%20%28f%2C%20a%20proxy%20of%20intracellular%20sodium%20homeostasis%29.%20Compared%20to%20controls%2C%20patients%20showed%20increased%20TSC%20in%20both%20epileptogenic%20and%20non-epileptogenic%20zones%2C%20and%20this%20increase%20in%20TSC%20was%20consistent%20in%20both%20hub%20and%20non-hub%20regions.%20On%20the%20contrary%2C%20f%20was%20increased%20only%20within%20the%20epileptogenic%20zones%20and%20was%20not%20affected%20by%20the%20hubness%20of%20a%20region.%20Our%20results%20also%20confirm%20the%20whole%20brain%20increase%20in%20TSC%20and%20the%20local%20increase%20of%20the%20f%20value%20within%20epileptogenic%20zones%20previously%20observed%20in%20focal%20epilepsy%20patients.%20Therefore%2C%20we%20propose%20that%20sodium%20imaging%20can%20probe%20distinct%20tissue%20properties%3A%20TSC%20appears%20sensitive%20to%20microstructural%20alterations%2C%20while%20f%20could%20reflect%20homeostatic%20disruptions%20specific%20to%20epileptogenic%20regions.%22%2C%22date%22%3A%222025-11-05%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1093%5C%2Fbrain%5C%2Fawaf409%22%2C%22ISSN%22%3A%221460-2156%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22KJQH9V8M%22%2C%22UP3H3ICX%22%2C%22HVJZKIZG%22%2C%22P66W67T8%22%2C%22F2AGIUQU%22%2C%22XTA6KS7L%22%2C%22FBQIKF54%22%2C%229RMECNPE%22%5D%2C%22dateModified%22%3A%222025-11-12T13%3A35%3A34Z%22%7D%7D%2C%7B%22key%22%3A%22R632UBY8%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22K%5Cu00fcstner%20et%20al.%22%2C%22parsedDate%22%3A%222025-06-14%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BK%26%23xFC%3Bstner%2C%20T.%2C%20Haast%2C%20R.%2C%20Priovoulos%2C%20N.%2C%20Clement%2C%20P.%20and%20Dos%20Santos%2C%20D.P.%20%282025%29%20%26%23x201C%3BESMRMB%202025%20focus%20topic%3A%20cycle%20of%20quality-from%20concept%20to%20clinical%20and%20scientific%20impact%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BMagma%20%28New%20York%2C%20N.Y.%29%26lt%3B%5C%2Fi%26gt%3B%20%5BPreprint%5D.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs10334-025-01272-0%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs10334-025-01272-0%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22ESMRMB%202025%20focus%20topic%3A%20cycle%20of%20quality-from%20concept%20to%20clinical%20and%20scientific%20impact%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22K%5Cu00fcstner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Roy%22%2C%22lastName%22%3A%22Haast%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nikos%22%2C%22lastName%22%3A%22Priovoulos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Patricia%22%2C%22lastName%22%3A%22Clement%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniel%20Pinto%22%2C%22lastName%22%3A%22Dos%20Santos%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222025-06-14%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1007%5C%2Fs10334-025-01272-0%22%2C%22ISSN%22%3A%221352-8661%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22FBQIKF54%22%5D%2C%22dateModified%22%3A%222025-06-16T08%3A00%3A34Z%22%7D%7D%2C%7B%22key%22%3A%22WIPJYKQS%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Uher%20et%20al.%22%2C%22parsedDate%22%3A%222025-06%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BUher%2C%20D.%2C%20Drenthen%2C%20G.S.%2C%20Hoeberigs%2C%20C.M.%2C%20van%20Lanen%2C%20R.H.G.J.%2C%20Colon%2C%20A.J.%2C%20Haast%2C%20R.A.M.%2C%20van%20Kranen-Mastenbroek%2C%20V.H.J.M.%2C%20Widman%2C%20G.%2C%20Hofman%2C%20P.A.M.%2C%20Wagner%2C%20L.G.%2C%20Beckervordersandforth%2C%20J.C.%2C%20Jansen%2C%20J.F.A.%2C%20Schijns%2C%20O.E.M.G.%2C%20Backes%2C%20W.H.%20and%20ACE%20study%20group%20%282025%29%20%26%23x201C%3BThe%20role%20of%20ultra-high%20field%20MRI%20and%20image%20processing%20in%20the%20presurgical%20workup%20in%20MRI-negative%20focal%20epilepsy%3A%20A%20validated%207T%20MRI%20case%20study%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BEpilepsy%20%26amp%3B%20Behavior%20Reports%26lt%3B%5C%2Fi%26gt%3B%2C%2030%2C%20p.%20100761.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.ebr.2025.100761%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.ebr.2025.100761%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22The%20role%20of%20ultra-high%20field%20MRI%20and%20image%20processing%20in%20the%20presurgical%20workup%20in%20MRI-negative%20focal%20epilepsy%3A%20A%20validated%207T%20MRI%20case%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniel%22%2C%22lastName%22%3A%22Uher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gerhard%20S.%22%2C%22lastName%22%3A%22Drenthen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christianne%20M.%22%2C%22lastName%22%3A%22Hoeberigs%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rick%20H.%20G.%20J.%22%2C%22lastName%22%3A%22van%20Lanen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Albert%20J.%22%2C%22lastName%22%3A%22Colon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Roy%20A.%20M.%22%2C%22lastName%22%3A%22Haast%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vivianne%20H.%20J.%20M.%22%2C%22lastName%22%3A%22van%20Kranen-Mastenbroek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guido%22%2C%22lastName%22%3A%22Widman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Paul%20A.%20M.%22%2C%22lastName%22%3A%22Hofman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Louis%20G.%22%2C%22lastName%22%3A%22Wagner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jan%20C.%22%2C%22lastName%22%3A%22Beckervordersandforth%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jacobus%20F.%20A.%22%2C%22lastName%22%3A%22Jansen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Olaf%20E.%20M.%20G.%22%2C%22lastName%22%3A%22Schijns%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Walter%20H.%22%2C%22lastName%22%3A%22Backes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22ACE%20study%20group%22%7D%5D%2C%22abstractNote%22%3A%22This%20case%20study%20demonstrates%20the%20value%20of%20combined%207%5Cu00a0T%20structural%20and%20functional%20MRI%20in%20the%20presurgical%20workup%20of%20a%2024-year-old%20male%20with%20drug-resistant%20focal%20epilepsy%20who%20was%20initially%20considered%20MRI-negative%20on%20clinical%203%5Cu00a0T%20MRI.%20The%20patient%20underwent%20extensive%20presurgical%20workup%20with%207%5Cu00a0T%20MRI%2C%20magnetoencephalography%2C%20stereo-electroencephalography%2C%20and%20resection%20of%20the%20suspected%20right%20frontal%20epileptogenic%20zone.%20Histopathology%20showed%20focal%20cortical%20dysplasia%20%28FCD%29%20type%20IIb.%20The%20patient%20remained%2011%5Cu00a0months%20after%20surgery%20seizure-free.%20Retrospective%20analysis%20revealed%20that%20both%20structural%20and%20functional%207%5Cu00a0T%20MRI%20showed%20abnormalities%20within%20the%20resected%20area.%20Morphometric%20Analysis%20Program%20%28MAP18%29%20detected%20abnormalities%20on%20both%203%5Cu00a0T%20and%207%5Cu00a0T%20images.%20However%2C%20abnormalities%20were%20more%20conspicuous%20on%207%5Cu00a0T.%20Resting-state%20functional%20MRI%20metrics%2C%20particularly%20regional%20homogeneity%20and%20fractional%20amplitude%20of%20low-frequency%20fluctuations%2C%20demonstrated%20significantly%20increased%20values%20in%20both%20a%20MAP18-defined%20region%20of%20interest%20and%20the%20entire%20resected%20area%20compared%20to%20a%20healthy%20control%20group%20%28p%5Cu00a0%26lt%3B%5Cu00a00.05%29.%20However%2C%20extensive%20unspecific%20abnormalities%20were%20also%20observed%20outside%20the%20resected%20region%2C%20highlighting%20the%20importance%20of%20a%20multimodal%20approach.%20This%20case%20study%20illustrates%20that%20advanced%20image%20processing%20of%20ultra-high%20field%20structural%20and%20resting-state%20functional%20MRI%20scans%20may%20enhance%20the%20detection%20of%20subtle%20epileptogenic%20lesions%20in%20presurgical%20evaluation%2C%20potentially%20improving%20post-operative%20seizure%20outcome%20and%20associated%20quality%20of%20life.%22%2C%22date%22%3A%222025-06%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.ebr.2025.100761%22%2C%22ISSN%22%3A%222589-9864%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22FBQIKF54%22%5D%2C%22dateModified%22%3A%222025-04-03T15%3A09%3A13Z%22%7D%7D%2C%7B%22key%22%3A%22DNR3BIPC%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Mourre%20et%20al.%22%2C%22parsedDate%22%3A%222025-05-19%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BMourre%2C%20H.%2C%20Makhalova%2C%20J.%2C%20Soncin%2C%20L.%2C%20Garnier%2C%20E.%2C%20Dary%2C%20H.%2C%20Le%20Troter%2C%20A.%2C%20Haast%2C%20R.A.M.%2C%20Testud%2C%20B.%2C%20Arthuis%2C%20M.%2C%20Villalon%2C%20S.M.%2C%20Lagarde%2C%20S.%2C%20Pizzo%2C%20F.%2C%20B%26%23xE9%3Bnar%2C%20C.%2C%20Ranjeva%2C%20J.-P.%2C%20Guye%2C%20M.%20and%20Bartolomei%2C%20F.%20%282025%29%20%26%23x201C%3BNuclei-Specific%20Amygdala%20Enlargement%20Is%20Linked%20to%20Psychiatric%20Comorbidities%20in%20Drug-Resistant%20Focal%20Epilepsy%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BAnnals%20of%20Clinical%20and%20Translational%20Neurology%26lt%3B%5C%2Fi%26gt%3B%20%5BPreprint%5D.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Facn3.70071%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Facn3.70071%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Nuclei-Specific%20Amygdala%20Enlargement%20Is%20Linked%20to%20Psychiatric%20Comorbidities%20in%20Drug-Resistant%20Focal%20Epilepsy%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22H%5Cu00e9l%5Cu00e8ne%22%2C%22lastName%22%3A%22Mourre%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Makhalova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lisa%22%2C%22lastName%22%3A%22Soncin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elodie%22%2C%22lastName%22%3A%22Garnier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hugo%22%2C%22lastName%22%3A%22Dary%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Arnaud%22%2C%22lastName%22%3A%22Le%20Troter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Roy%20A.%20M.%22%2C%22lastName%22%3A%22Haast%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benoit%22%2C%22lastName%22%3A%22Testud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marie%22%2C%22lastName%22%3A%22Arthuis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Samuel%20Medina%22%2C%22lastName%22%3A%22Villalon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stanislas%22%2C%22lastName%22%3A%22Lagarde%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Francesca%22%2C%22lastName%22%3A%22Pizzo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christian%22%2C%22lastName%22%3A%22B%5Cu00e9nar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Philippe%22%2C%22lastName%22%3A%22Ranjeva%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maxime%22%2C%22lastName%22%3A%22Guye%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabrice%22%2C%22lastName%22%3A%22Bartolomei%22%7D%5D%2C%22abstractNote%22%3A%22OBJECTIVE%3A%20Amygdala%20enlargement%20has%20been%20the%20subject%20of%20controversial%20studies%20regarding%20its%20significance%20in%20terms%20of%20pathogenicity%20both%20in%20epilepsy%20and%20in%20psychiatric%20comorbidities%20such%20as%20anxiety%2C%20depression%2C%20and%20post-traumatic%20stress%20disorder.%20However%2C%20no%20causal%20link%20has%20been%20established%20in%20either%20direction%2C%20and%20the%20role%20of%20distinct%20amygdala%20nuclei%20remains%20unknown.%20We%20investigated%20volumetric%20changes%20of%20the%20amygdala%20and%20its%20nine%20main%20nuclei%20and%20their%20associations%20with%20psychiatric%20comorbidities%20in%20patients%20with%20drug-resistant%20focal%20epilepsy.%5CnMETHODS%3A%20Eighty-seven%20adult%20patients%20with%20drug-resistant%20focal%20epilepsy%2C%20available%207%5Cu2009T%20MRI%2C%20and%20completed%20standardized%20psychiatric%20assessments%20were%20included.%20Whole%20amygdala%20and%20nuclei%20volumes%20were%20quantified%20and%20compared%20to%20healthy%20controls.%20Correlations%20between%20the%20amygdala%20or%20nuclei%20volumes%20and%20psychiatric%20scores%20were%20analyzed%2C%20as%20well%20as%20the%20prevalence%20and%20severity%20of%20each%20comorbidity%20depending%20on%20the%20presence%20of%20enlargement.%5CnRESULTS%3A%20Amygdala%20enlargement%20was%20present%20in%2041%25%20of%20patients%2C%20with%20bilateral%20enlargement%20observed%20in%2030%25%20of%20these%20cases%2C%20while%20atrophy%20was%20noted%20in%202%25.%20Bilateral%20enlargement%20correlated%20with%20higher%20posttraumatic%20stress%20disorder%20and%20depression%20scores.%20Central%20nucleus%20enlargement%20was%20associated%20with%20a%20greater%20prevalence%20of%20depression%20and%20more%20severe%20anxiety.%20Bilateral%20enlargement%20of%20distinct%20nuclei%20in%20the%20basolateral%20group%20was%20linked%20to%20more%20severe%20depression%20or%20posttraumatic%20stress%20disorder.%5CnINTERPRETATION%3A%20These%20findings%20suggest%20that%20bilateral%20amygdala%20enlargement%2C%20particularly%20in%20specific%20nuclei%2C%20may%20serve%20as%20a%20morphological%20marker%20of%20psychiatric%20comorbidities%20in%20epilepsy.%20Further%20research%20is%20needed%20to%20explore%20the%20specific%20roles%20of%20amygdala%20nuclei%20in%20psycho-epileptogenesis.%22%2C%22date%22%3A%222025-05-19%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1002%5C%2Facn3.70071%22%2C%22ISSN%22%3A%222328-9503%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22UP3H3ICX%22%2C%225P5FWCR9%22%2C%22XTA6KS7L%22%2C%22FBQIKF54%22%5D%2C%22dateModified%22%3A%222025-05-27T08%3A14%3A24Z%22%7D%7D%2C%7B%22key%22%3A%22BP6HP22F%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Segobin%20et%20al.%22%2C%22parsedDate%22%3A%222024-12%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BSegobin%2C%20S.%2C%20Haast%2C%20R.A.M.%2C%20Kumar%2C%20V.J.%2C%20Lella%2C%20A.%2C%20Alkemade%2C%20A.%2C%20Bach%20Cuadra%2C%20M.%2C%20Barbeau%2C%20E.J.%2C%20Felician%2C%20O.%2C%20Pergola%2C%20G.%2C%20Pitel%2C%20A.-L.%2C%20Saranathan%2C%20M.%2C%20Tourdias%2C%20T.%20and%20Hornberger%2C%20M.%20%282024%29%20%26%23x201C%3BA%20roadmap%20towards%20standardized%20neuroimaging%20approaches%20for%20human%20thalamic%20nuclei%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BNature%20Reviews%20Neuroscience%26lt%3B%5C%2Fi%26gt%3B%2C%2025%2812%29%2C%20pp.%20792%26%23x2013%3B808.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41583-024-00867-1%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41583-024-00867-1%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22A%20roadmap%20towards%20standardized%20neuroimaging%20approaches%20for%20human%20thalamic%20nuclei%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shailendra%22%2C%22lastName%22%3A%22Segobin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Roy%20A.%20M.%22%2C%22lastName%22%3A%22Haast%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vinod%20Jangir%22%2C%22lastName%22%3A%22Kumar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annalisa%22%2C%22lastName%22%3A%22Lella%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anneke%22%2C%22lastName%22%3A%22Alkemade%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Meritxell%22%2C%22lastName%22%3A%22Bach%20Cuadra%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuel%20J.%22%2C%22lastName%22%3A%22Barbeau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Olivier%22%2C%22lastName%22%3A%22Felician%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Giulio%22%2C%22lastName%22%3A%22Pergola%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne-Lise%22%2C%22lastName%22%3A%22Pitel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Manojkumar%22%2C%22lastName%22%3A%22Saranathan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Tourdias%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Hornberger%22%7D%5D%2C%22abstractNote%22%3A%22The%20thalamus%20has%20a%20key%20role%20in%20mediating%20cortical%5Cu2013subcortical%20interactions%20but%20is%20often%20neglected%20in%20neuroimaging%20studies%2C%20which%20mostly%20focus%20on%20changes%20in%20cortical%20structure%20and%20activity.%20One%20of%20the%20main%20reasons%20for%20the%20thalamus%20being%20overlooked%20is%20that%20the%20delineation%20of%20individual%20thalamic%20nuclei%20via%20neuroimaging%20remains%20controversial.%20Indeed%2C%20neuroimaging%20atlases%20vary%20substantially%20regarding%20which%20thalamic%20nuclei%20are%20included%20and%20how%20their%20delineations%20were%20established.%20Here%2C%20we%20review%20current%20and%20emerging%20methods%20for%20thalamic%20nuclei%20segmentation%20in%20neuroimaging%20data%20and%20consider%20the%20limitations%20of%20existing%20techniques%20in%20terms%20of%20their%20research%20and%20clinical%20applicability.%20We%20address%20these%20challenges%20by%20proposing%20a%20roadmap%20to%20improve%20thalamic%20nuclei%20segmentation%20in%20human%20neuroimaging%20and%2C%20in%20turn%2C%20harmonize%20research%20approaches%20and%20advance%20clinical%20applications.%20We%20believe%20that%20a%20collective%20effort%20is%20required%20to%20achieve%20this.%20We%20hope%20that%20this%20will%20ultimately%20lead%20to%20the%20thalamic%20nuclei%20being%20regarded%20as%20key%20brain%20regions%20in%20their%20own%20right%20and%20not%20%28as%20often%20currently%20assumed%29%20as%20simply%20a%20gateway%20between%20cortical%20and%20subcortical%20regions.%22%2C%22date%22%3A%222024-12%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41583-024-00867-1%22%2C%22ISSN%22%3A%221471-0048%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41583-024-00867-1%22%2C%22collections%22%3A%5B%22FBQIKF54%22%5D%2C%22dateModified%22%3A%222025-09-12T07%3A58%3A58Z%22%7D%7D%2C%7B%22key%22%3A%22GV2CMIC2%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Chakraborty%20et%20al.%22%2C%22parsedDate%22%3A%222024-10-18%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BChakraborty%2C%20S.%2C%20Haast%2C%20R.A.M.%2C%20Onuska%2C%20K.M.%2C%20Kanel%2C%20P.%2C%20Prado%2C%20M.A.M.%2C%20Prado%2C%20V.F.%2C%20Khan%2C%20A.R.%20and%20Schmitz%2C%20T.W.%20%282024%29%20%26%23x201C%3BMultimodal%20gradients%20of%20basal%20forebrain%20connectivity%20across%20the%20neocortex%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BNature%20Communications%26lt%3B%5C%2Fi%26gt%3B%2C%2015%281%29%2C%20p.%208990.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41467-024-53148-x%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41467-024-53148-x%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Multimodal%20gradients%20of%20basal%20forebrain%20connectivity%20across%20the%20neocortex%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sudesna%22%2C%22lastName%22%3A%22Chakraborty%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Roy%20A.%20M.%22%2C%22lastName%22%3A%22Haast%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kate%20M.%22%2C%22lastName%22%3A%22Onuska%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Prabesh%22%2C%22lastName%22%3A%22Kanel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marco%20A.%20M.%22%2C%22lastName%22%3A%22Prado%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vania%20F.%22%2C%22lastName%22%3A%22Prado%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ali%20R.%22%2C%22lastName%22%3A%22Khan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Taylor%20W.%22%2C%22lastName%22%3A%22Schmitz%22%7D%5D%2C%22abstractNote%22%3A%22Cortical%20cholinergic%20projections%20originate%20from%20subregions%20of%20the%20basal%20forebrain%20%28BF%29.%20To%20examine%20its%20organization%20in%20humans%2C%20we%20computed%20multimodal%20gradients%20of%20BF%20connectivity%20by%20combining%207%5Cu2009T%20diffusion%20and%20resting%20state%20functional%20MRI.%20Moving%20from%20anteromedial%20to%20posterolateral%20BF%2C%20we%20observe%20reduced%20tethering%20between%20structural%20and%20functional%20connectivity%20gradients%2C%20with%20the%20lowest%20tethering%20in%20the%20nucleus%20basalis%20of%20Meynert.%20In%20the%20neocortex%2C%20this%20gradient%20is%20expressed%20by%20progressively%20reduced%20tethering%20from%20unimodal%20sensory%20to%20transmodal%20cortex%2C%20with%20the%20lowest%20tethering%20in%20the%20midcingulo-insular%20network%2C%20and%20is%20also%20spatially%20correlated%20with%20the%20molecular%20concentration%20of%20VAChT%2C%20measured%20by%20%5B18F%5Dfluoroethoxy-benzovesamicol%20%28FEOBV%29%20PET.%20In%20mice%2C%20viral%20tracing%20of%20BF%20cholinergic%20projections%20and%20%5B18F%5DFEOBV%20PET%20confirm%20a%20gradient%20of%20axonal%20arborization.%20Altogether%2C%20our%20findings%20reveal%20that%20BF%20cholinergic%20neurons%20vary%20in%20their%20branch%20complexity%2C%20with%20certain%20subpopulations%20exhibiting%20greater%20modularity%20and%20others%20greater%20diffusivity%20in%20the%20functional%20integration%20with%20their%20cortical%20targets.%22%2C%22date%22%3A%222024-10-18%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41467-024-53148-x%22%2C%22ISSN%22%3A%222041-1723%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22B4EWFM7E%22%2C%22FBQIKF54%22%5D%2C%22dateModified%22%3A%222025-09-12T07%3A59%3A44Z%22%7D%7D%2C%7B%22key%22%3A%22DWGHA69D%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Pinto%20et%20al.%22%2C%22parsedDate%22%3A%222024-07-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BPinto%2C%20J.%2C%20McGee%2C%20A.%2C%20Mattern%2C%20H.%2C%20Markenroth%20Bloch%2C%20K.%2C%20Haast%2C%20R.A.M.%2C%20K%26%23xFC%3Bstner%2C%20T.%20and%20Vannesjo%2C%20S.J.%20%282024%29%20%26%23x201C%3BESMRMB%202024%20focus%20topic%20%26%23x2018%3BMR%20Beyond%20Structures%3A%26%23xA0%3BThe%20dynamic%20body%20at%20different%20scales%2C%26%23x2019%3B%26%23x201D%3B%20%26lt%3Bi%26gt%3BMagnetic%20Resonance%20Materials%20in%20Physics%2C%20Biology%20and%20Medicine%26lt%3B%5C%2Fi%26gt%3B%2C%2037%283%29%2C%20pp.%20319%26%23x2013%3B319.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs10334-024-01175-6%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs10334-024-01175-6%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22ESMRMB%202024%20focus%20topic%20%5Cu201cMR%20Beyond%20Structures%3A%5Cu00a0The%20dynamic%20body%20at%20different%20scales%5Cu201d%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joana%22%2C%22lastName%22%3A%22Pinto%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Allison%22%2C%22lastName%22%3A%22McGee%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hendrik%22%2C%22lastName%22%3A%22Mattern%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%22%2C%22lastName%22%3A%22Markenroth%20Bloch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Roy%20A.%20M.%22%2C%22lastName%22%3A%22Haast%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22K%5Cu00fcstner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%20Johanna%22%2C%22lastName%22%3A%22Vannesjo%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222024-07-01%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1007%5C%2Fs10334-024-01175-6%22%2C%22ISSN%22%3A%221352-8661%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs10334-024-01175-6%22%2C%22collections%22%3A%5B%22FBQIKF54%22%5D%2C%22dateModified%22%3A%222025-09-12T07%3A59%3A45Z%22%7D%7D%2C%7B%22key%22%3A%22LWVY9B6Y%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Chakraborty%20et%20al.%22%2C%22parsedDate%22%3A%222024%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BChakraborty%2C%20S.%2C%20Lee%2C%20S.K.%2C%20Arnold%2C%20S.M.%2C%20Haast%2C%20R.A.M.%2C%20Khan%2C%20A.R.%20and%20Schmitz%2C%20T.W.%20%282024%29%20%26%23x201C%3BFocal%20acetylcholinergic%20modulation%20of%20the%20human%20midcingulo-insular%20network%20during%20attention%3A%20Meta-analytic%20neuroimaging%20and%20behavioral%20evidence%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BJournal%20of%20Neurochemistry%26lt%3B%5C%2Fi%26gt%3B%2C%20168%284%29%2C%20pp.%20397%26%23x2013%3B413.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fjnc.15990%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fjnc.15990%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Focal%20acetylcholinergic%20modulation%20of%20the%20human%20midcingulo-insular%20network%20during%20attention%3A%20Meta-analytic%20neuroimaging%20and%20behavioral%20evidence%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sudesna%22%2C%22lastName%22%3A%22Chakraborty%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sun%20Kyun%22%2C%22lastName%22%3A%22Lee%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sarah%20M.%22%2C%22lastName%22%3A%22Arnold%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Roy%20A.%20M.%22%2C%22lastName%22%3A%22Haast%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ali%20R.%22%2C%22lastName%22%3A%22Khan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Taylor%20W.%22%2C%22lastName%22%3A%22Schmitz%22%7D%5D%2C%22abstractNote%22%3A%22The%20basal%20forebrain%20cholinergic%20neurons%20provide%20acetylcholine%20to%20the%20cortex%20via%20large%20projections.%20Recent%20molecular%20imaging%20work%20in%20humans%20indicates%20that%20the%20cortical%20cholinergic%20innervation%20is%20not%20uniformly%20distributed%2C%20but%20rather%20may%20disproportionately%20innervate%20cortical%20areas%20relevant%20to%20supervisory%20attention.%20In%20this%20study%2C%20we%20therefore%20reexamined%20the%20spatial%20relationship%20between%20acetylcholinergic%20modulation%20and%20attention%20in%20the%20human%20cortex%20using%20meta-analytic%20strategies%20targeting%20both%20pharmacological%20and%20non-pharmacological%20neuroimaging%20studies.%20We%20found%20that%20pharmaco-modulation%20of%20acetylcholine%20evoked%20both%20increased%20activity%20in%20the%20anterior%20cingulate%20and%20decreased%20activity%20in%20the%20opercular%20and%20insular%20cortex.%20In%20large%20independent%20meta-analyses%20of%20non-pharmacological%20neuroimaging%20research%2C%20we%20demonstrate%20that%20during%20attentional%20engagement%20these%20cortical%20areas%20exhibit%20%281%29%20task-related%20co-activation%20with%20the%20basal%20forebrain%2C%20%282%29%20task-related%20co-activation%20with%20one%20another%2C%20and%20%283%29%20spatial%20overlap%20with%20dense%20cholinergic%20innervations%20originating%20from%20the%20basal%20forebrain%2C%20as%20estimated%20by%20multimodal%20positron%20emission%20tomography%20and%20magnetic%20resonance%20imaging.%20Finally%2C%20we%20provide%20meta-analytic%20evidence%20that%20pharmaco-modulation%20of%20acetylcholine%20also%20induces%20a%20speeding%20of%20responses%20to%20targets%20with%20no%20apparent%20tradeoff%20in%20accuracy.%20In%20sum%2C%20we%20demonstrate%20in%20humans%20that%20acetylcholinergic%20modulation%20of%20midcingulo-insular%20hubs%20of%20the%20ventral%20attention%5C%2Fsalience%20network%20via%20basal%20forebrain%20afferents%20may%20coordinate%20selection%20of%20task%20relevant%20information%2C%20thereby%20facilitating%20cognition%20and%20behavior.%22%2C%22date%22%3A%222024%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1111%5C%2Fjnc.15990%22%2C%22ISSN%22%3A%221471-4159%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fonlinelibrary.wiley.com%5C%2Fdoi%5C%2Fabs%5C%2F10.1111%5C%2Fjnc.15990%22%2C%22collections%22%3A%5B%22FBQIKF54%22%5D%2C%22dateModified%22%3A%222025-09-12T07%3A59%3A45Z%22%7D%7D%2C%7B%22key%22%3A%22GRXQFTBW%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Haast%20et%20al.%22%2C%22parsedDate%22%3A%222023%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BHaast%2C%20R.A.M.%2C%20Testud%2C%20B.%2C%20Makhalova%2C%20J.%2C%20Dary%2C%20H.%2C%20Cabane%2C%20A.%2C%20Le%20Troter%2C%20A.%2C%20Ranjeva%2C%20J.-P.%2C%20Bartolomei%2C%20F.%20and%20Guye%2C%20M.%20%282023%29%20%26%23x201C%3BMulti-scale%20structural%20alterations%20of%20the%20thalamus%20and%20basal%20ganglia%20in%20focal%20epilepsy%20using%207T%20MRI%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BHuman%20Brain%20Mapping%26lt%3B%5C%2Fi%26gt%3B%2C%2044%2813%29%2C%20pp.%204754%26%23x2013%3B4771.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fhbm.26414%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fhbm.26414%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Multi-scale%20structural%20alterations%20of%20the%20thalamus%20and%20basal%20ganglia%20in%20focal%20epilepsy%20using%207T%20MRI%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Roy%20A.%20M.%22%2C%22lastName%22%3A%22Haast%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benoit%22%2C%22lastName%22%3A%22Testud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Makhalova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hugo%22%2C%22lastName%22%3A%22Dary%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandre%22%2C%22lastName%22%3A%22Cabane%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Arnaud%22%2C%22lastName%22%3A%22Le%20Troter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Philippe%22%2C%22lastName%22%3A%22Ranjeva%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabrice%22%2C%22lastName%22%3A%22Bartolomei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maxime%22%2C%22lastName%22%3A%22Guye%22%7D%5D%2C%22abstractNote%22%3A%22Focal%20epilepsy%20is%20characterized%20by%20repeated%20spontaneous%20seizures%20that%20originate%20from%20cortical%20epileptogenic%20zone%20networks%20%28EZN%29.%20Analysis%20of%20intracerebral%20recordings%20showed%20that%20subcortical%20structures%2C%20and%20in%20particular%20the%20thalamus%2C%20play%20an%20important%20role%20in%20seizure%20dynamics%20as%20well%2C%20supporting%20their%20structural%20alterations%20reported%20in%20the%20neuroimaging%20literature.%20Nonetheless%2C%20between-patient%20differences%20in%20EZN%20localization%20%28e.g.%2C%20temporal%20vs.%20non-temporal%20lobe%20epilepsy%29%20as%20well%20as%20extension%20%28i.e.%2C%20number%20of%20epileptogenic%20regions%29%20might%20impact%20the%20magnitude%20as%20well%20as%20spatial%20distribution%20of%20subcortical%20structural%20changes.%20Here%20we%20used%207%20Tesla%20MRI%20T1%20data%20to%20provide%20an%20unprecedented%20description%20of%20subcortical%20morphological%20%28volume%2C%20tissue%20deformation%2C%20and%20shape%29%20and%20longitudinal%20relaxation%20%28T1%29%20changes%20in%20focal%20epilepsy%20patients%20and%20evaluate%20the%20impact%20of%20the%20EZN%20and%20other%20patient-specific%20clinical%20features.%20Our%20results%20showed%20variable%20levels%20of%20atrophy%20across%20thalamic%20nuclei%20that%20appeared%20most%20prominent%20in%20the%20temporal%20lobe%20epilepsy%20group%20and%20the%20side%20ipsilateral%20to%20the%20EZN%2C%20while%20shortening%20of%20T1%20was%20especially%20observed%20for%20the%20lateral%20thalamus.%20Multivariate%20analyses%20across%20thalamic%20nuclei%20and%20basal%20ganglia%20showed%20that%20volume%20acted%20as%20the%20dominant%20discriminator%20between%20patients%20and%20controls%2C%20while%20%28posterolateral%29%20thalamic%20T1%20measures%20looked%20promising%20to%20further%20differentiate%20patients%20based%20on%20EZN%20localization.%20In%20particular%2C%20the%20observed%20differences%20in%20T1%20changes%20between%20thalamic%20nuclei%20indicated%20differential%20involvement%20based%20on%20EZN%20localization.%20Finally%2C%20EZN%20extension%20was%20found%20to%20best%20explain%20the%20observed%20variability%20between%20patients.%20To%20conclude%2C%20this%20work%20revealed%20multi-scale%20subcortical%20alterations%20in%20focal%20epilepsy%20as%20well%20as%20their%20dependence%20on%20several%20clinical%20characteristics.%22%2C%22date%22%3A%222023%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1002%5C%2Fhbm.26414%22%2C%22ISSN%22%3A%221097-0193%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fonlinelibrary.wiley.com%5C%2Fdoi%5C%2Fabs%5C%2F10.1002%5C%2Fhbm.26414%22%2C%22collections%22%3A%5B%22UP3H3ICX%22%2C%225P5FWCR9%22%2C%22XTA6KS7L%22%2C%22FBQIKF54%22%2C%22PCMV2W5C%22%2C%229RMECNPE%22%5D%2C%22dateModified%22%3A%222025-09-19T07%3A46%3A00Z%22%7D%7D%2C%7B%22key%22%3A%229Y6H4YSN%22%2C%22library%22%3A%7B%22id%22%3A180164%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Kai%20et%20al.%22%2C%22parsedDate%22%3A%222022-11-15%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BKai%2C%20J.%2C%20Khan%2C%20A.R.%2C%20Haast%2C%20R.A.%20and%20Lau%2C%20J.C.%20%282022%29%20%26%23x201C%3BMapping%20the%20subcortical%20connectome%20using%20in%20vivo%20diffusion%20MRI%3A%20Feasibility%20and%20reliability%2C%26%23x201D%3B%20%26lt%3Bi%26gt%3BNeuroImage%26lt%3B%5C%2Fi%26gt%3B%2C%20262%2C%20p.%20119553.%20Available%20at%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.neuroimage.2022.119553%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.neuroimage.2022.119553%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Mapping%20the%20subcortical%20connectome%20using%20in%20vivo%20diffusion%20MRI%3A%20Feasibility%20and%20reliability%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jason%22%2C%22lastName%22%3A%22Kai%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ali%20R%22%2C%22lastName%22%3A%22Khan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Roy%20AM%22%2C%22lastName%22%3A%22Haast%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jonathan%20C%22%2C%22lastName%22%3A%22Lau%22%7D%5D%2C%22abstractNote%22%3A%22Tractography%20combined%20with%20regions%20of%20interest%20%28ROIs%29%20has%20been%20used%20to%20non-invasively%20study%20the%20structural%20connectivity%20of%20the%20cortex%20as%20well%20as%20to%20assess%20the%20reliability%20of%20these%20connections.%20However%2C%20the%20subcortical%20connectome%20%28subcortex%20to%20subcortex%29%20has%20not%20been%20comprehensively%20examined%2C%20in%20part%20due%20to%20the%20difficulty%20of%20performing%20tractography%20in%20this%20complex%20and%20compact%20region.%20In%20this%20study%2C%20we%20performed%20an%20in%20vivo%20investigation%20using%20tractography%20to%20assess%20the%20feasibility%20and%20reliability%20of%20mapping%20known%20connections%20between%20structures%20of%20the%20subcortex%20using%20the%20test-retest%20dataset%20from%20the%20Human%20Connectome%20Project%20%28HCP%29.%20We%20further%20validated%20our%20observations%20using%20a%20separate%20unrelated%20subjects%20dataset%20from%20the%20HCP.%20Quantitative%20assessment%20was%20performed%20by%20computing%20tract%20densities%20and%20spatial%20overlap%20of%20identified%20connections%20between%20subcortical%20ROIs.%20Further%2C%20known%20connections%20between%20structures%20of%20the%20basal%20ganglia%20and%20thalamus%20were%20identified%20and%20visually%20inspected%2C%20comparing%20tractography%20reconstructed%20trajectories%20with%20descriptions%20from%20tract-tracing%20studies.%20Our%20observations%20demonstrate%20both%20the%20feasibility%20and%20reliability%20of%20using%20a%20data-driven%20tractography-based%20approach%20to%20map%20the%20subcortical%20connectome%20in%20vivo.%22%2C%22date%22%3A%222022-11-15%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.neuroimage.2022.119553%22%2C%22ISSN%22%3A%221053-8119%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.sciencedirect.com%5C%2Fscience%5C%2Farticle%5C%2Fpii%5C%2FS1053811922006681%22%2C%22collections%22%3A%5B%22FBQIKF54%22%5D%2C%22dateModified%22%3A%222024-07-26T08%3A16%3A14Z%22%7D%7D%5D%7D
Gauer, L., Haast, R.A.M., Azilinon, M., El Mendili, M.M., Makhalova, J., Dary, H., Dinkelacker, V., Ridley, B., Ranjeva, J.-P., Zaaraoui, W., Bartolomei, F. and Guye, M. (2025) “Investigating sodium homeostasis of structural brain hubs in focal epilepsy using 7 T MRI,” Brain: A Journal of Neurology, p. awaf409. Available at: https://doi.org/10.1093/brain/awaf409.
Küstner, T., Haast, R., Priovoulos, N., Clement, P. and Dos Santos, D.P. (2025) “ESMRMB 2025 focus topic: cycle of quality-from concept to clinical and scientific impact,” Magma (New York, N.Y.) [Preprint]. Available at: https://doi.org/10.1007/s10334-025-01272-0.
Uher, D., Drenthen, G.S., Hoeberigs, C.M., van Lanen, R.H.G.J., Colon, A.J., Haast, R.A.M., van Kranen-Mastenbroek, V.H.J.M., Widman, G., Hofman, P.A.M., Wagner, L.G., Beckervordersandforth, J.C., Jansen, J.F.A., Schijns, O.E.M.G., Backes, W.H. and ACE study group (2025) “The role of ultra-high field MRI and image processing in the presurgical workup in MRI-negative focal epilepsy: A validated 7T MRI case study,” Epilepsy & Behavior Reports, 30, p. 100761. Available at: https://doi.org/10.1016/j.ebr.2025.100761.
Mourre, H., Makhalova, J., Soncin, L., Garnier, E., Dary, H., Le Troter, A., Haast, R.A.M., Testud, B., Arthuis, M., Villalon, S.M., Lagarde, S., Pizzo, F., Bénar, C., Ranjeva, J.-P., Guye, M. and Bartolomei, F. (2025) “Nuclei-Specific Amygdala Enlargement Is Linked to Psychiatric Comorbidities in Drug-Resistant Focal Epilepsy,” Annals of Clinical and Translational Neurology [Preprint]. Available at: https://doi.org/10.1002/acn3.70071.
Segobin, S., Haast, R.A.M., Kumar, V.J., Lella, A., Alkemade, A., Bach Cuadra, M., Barbeau, E.J., Felician, O., Pergola, G., Pitel, A.-L., Saranathan, M., Tourdias, T. and Hornberger, M. (2024) “A roadmap towards standardized neuroimaging approaches for human thalamic nuclei,” Nature Reviews Neuroscience, 25(12), pp. 792–808. Available at: https://doi.org/10.1038/s41583-024-00867-1.
Chakraborty, S., Haast, R.A.M., Onuska, K.M., Kanel, P., Prado, M.A.M., Prado, V.F., Khan, A.R. and Schmitz, T.W. (2024) “Multimodal gradients of basal forebrain connectivity across the neocortex,” Nature Communications, 15(1), p. 8990. Available at: https://doi.org/10.1038/s41467-024-53148-x.
Pinto, J., McGee, A., Mattern, H., Markenroth Bloch, K., Haast, R.A.M., Küstner, T. and Vannesjo, S.J. (2024) “ESMRMB 2024 focus topic ‘MR Beyond Structures: The dynamic body at different scales,’” Magnetic Resonance Materials in Physics, Biology and Medicine, 37(3), pp. 319–319. Available at: https://doi.org/10.1007/s10334-024-01175-6.
Chakraborty, S., Lee, S.K., Arnold, S.M., Haast, R.A.M., Khan, A.R. and Schmitz, T.W. (2024) “Focal acetylcholinergic modulation of the human midcingulo-insular network during attention: Meta-analytic neuroimaging and behavioral evidence,” Journal of Neurochemistry, 168(4), pp. 397–413. Available at: https://doi.org/10.1111/jnc.15990.
Haast, R.A.M., Testud, B., Makhalova, J., Dary, H., Cabane, A., Le Troter, A., Ranjeva, J.-P., Bartolomei, F. and Guye, M. (2023) “Multi-scale structural alterations of the thalamus and basal ganglia in focal epilepsy using 7T MRI,” Human Brain Mapping, 44(13), pp. 4754–4771. Available at: https://doi.org/10.1002/hbm.26414.
Kai, J., Khan, A.R., Haast, R.A. and Lau, J.C. (2022) “Mapping the subcortical connectome using in vivo diffusion MRI: Feasibility and reliability,” NeuroImage, 262, p. 119553. Available at: https://doi.org/10.1016/j.neuroimage.2022.119553.
Related Posts