Multiple Sclerosis

Research Works

Title: Multiple Sclerosis and Central Nervous System Demyelinating Diseases

Principal investigator(s): Jean Pelletier

Member List:
Bertrand Audoin, Adil Maarouf, Audrey Rico, Anthony Faivre, Clémence Boutière, Soraya Gherib, Marie Pierre Ranjeva, Françoise Reuter, Fanelly Parriollaud
Jean Philippe Ranjeva, Wafaa Zaaraoui, Virginie Callot, Guillaume Duhamel, Olivier Girard, Ludovic de Rochefort, Arnaud Le Troter

Short Description:

Multiple sclerosis (MS) is the most frequent demyelinating disease of the central nervous system (CNS) and represents the first cause of non-traumatic neurological disability among young adults. MS is characterized by focal and diffuse inflammation of the white matter (WM) and grey matter (GM), which leads to demyelination and neuronal injury. One of the crucial therapeutic challenges in MS is to identify new strategies to promote myelin regeneration and protect CNS. There is a strong clinical relevance to better understand the mechanisms involved in inflammation, demyelination, remyelination and irreversible neuronal damage to propose new therapeutic strategies, and to follow up their efficacy over time using in vivo monitoring tools.
The MS Research projects developed by the MS Team at CRMBM/CEMEREM for more than 15 years. aim at providing relevant innovative in vivo and non-invasive MR parameters for the better understanding of the pathophysiology and dysfunction accompanying MS impacting public health.
MR techniques have provided important clues for the better understanding of disease progression in MS, now considered to be underlined by progressive neurodegeneration related to focal and diffuse inflammation and demyelination of the CNS. At this time, one important topic is the definition of imaging markers evidencing demyelination and neurodegeneration, now highly supposed to be related to irreversible clinical deficit. In addition, using Ultra High Fields, the ability to detect focal microvascular component specifically related to inflammation and demyelination will be increased. Assessing the focal and diffuse damage of white and grey matter will help to perform in vivo phenotyping. Our new clinical trials and cohort following early stage MS patients include these new markers applied to brain and spinal cord.

Associated Keywords

  • Applied Mathematics
  • Artificial Intelligence
  • Brain Connectivity
  • Connectivity
  • Dynamic MRI/MRS
  • Heart Failure
  • Image Processing
  • Image Registration
  • Image Segmentation
  • Inhomogenous Magnetization Transfer (ihMT)
  • k-space Acquisition
  • Metabolism
  • Energy metabolism
  • Microstructure/architecture
  • MR Physics / MR Method developments
  • Multiple Sclerosis
  • Neuropsychology
  • New Contrasts
  • New MR Biomarkers
  • Parallel Transmit
  • Quantitative Brain Multimodal imaging
  • Quantitative MRI
  • Quantitative MRS
  • Sodium Homeostatis
  • Sodium MRI
  • Spinal Cord
  • Ultra-high field MRI
  • X-Nuclei