Inhomogeneous Magnetization Transfer – ihMT


Research Works

 

The research interests of the ihMT team are focused on characterizing a new endogenous MR contrast, the inhomogeneous Magnetization Transfer (ihMT).
We aim at understanding the fundamental physical mechanisms underlying the ihMT signal but also at investigating its potential for myelin imaging in preclinical (animal model) and clinical (MS patients and other neurodegenerative diseases) contexts.

Our research is conducted within three main projects
Physical mechanisms of ihMT,
ihMT MR developments,
Applications of ihMT,

 

ihMTeam members
Guillaume Duhamel, PhD
Olivier Girard, PhD
Lucas Soustelle, PhD, post-doctoral fellow
Andreea Hertanu, PhD student

 

Collaborations
MR Physics: Radiology Dpt, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
Solid-state NMR of molecular assemblies: Institut Européen en Chimie et Biologie, Université Bordeaux, France

Neurobiology of myelin regeneration: Institut de Biologie et du développement de Marseille, Aix Marseille Université, France
Neurology: Neurology Dpt, La Timone Hospital, APHM, Marseille, France

 

Alumni
Victor Carvalho (PhD student, 2016-2020)
Samira Mchinda (PhD student, 2015-2019)
Valentin Prévost (PhD student, 2014-2018)

 

Selected Publications

2020:
Gopal Varma, Fanny Munsch, Brian Burns, Guillaume Duhamel, Olivier Girard, et al.. Three‐dimensional inhomogeneous magnetization transfer with rapid gradient‐echo (3D ihMTRAGE) imaging. Magnetic Resonance in Medicine, Wiley, 2020, ⟨10.1002/mrm.28324⟩ ⟨hal-02904183⟩

Victor N.D. Carvalho, Andreea Hertanu, Axelle Grélard, Samira Mchinda, Lucas Soustelle, et al.. MRI assessment of multiple dipolar relaxation time (T1D) components in biological tissues interpreted with a generalized inhomogeneous magnetization transfer (ihMT) model. Journal of Magnetic Resonance, Elsevier, 2020, 311, pp.106668. ⟨10.1016/j.jmr.2019.106668⟩ ⟨hal-02456394⟩

H. Rasoanandrianina, S. Demortière, A. Trabelsi, J.P. Ranjeva, O. Girard, et al.. Sensitivity of the Inhomogeneous Magnetization Transfer Imaging Technique to Spinal Cord Damage in Multiple Sclerosis. American Journal of Neuroradiology, American Society of Neuroradiology, 2020, 41 (5), pp.929-937. ⟨10.3174/ajnr.A6554⟩ ⟨hal-02869168⟩

2019:
G. Duhamel, V.H. Prevost, M. Cayre, A. Hertanu, S. Mchinda, et al.. Validating the sensitivity of inhomogeneous magnetization transfer (ihMT) MRI to myelin with fluorescence microscopy. NeuroImage, Elsevier, 2019, 199, pp.289-303. ⟨10.1016/j.neuroimage.2019.05.061⟩ ⟨hal-02156603⟩

2018:
G. Varma, O.M. Girard, S. Mchinda, V.H. Prevost, A.K. Grant, et al.. Low duty-cycle pulsed irradiation reduces magnetization transfer and increases the inhomogeneous magnetization transfer effect. Journal of Magnetic Resonance, Elsevier, 2018, 296, pp.60-71. ⟨10.1016/j.jmr.2018.08.004⟩ ⟨hal-02059549⟩

E. van Obberghen, S. Mchinda, A. Le Troter, V.H. Prevost, P. Viout, et al.. Evaluation of the Sensitivity of Inhomogeneous Magnetization Transfer (ihMT) MRI for Multiple Sclerosis. American Journal of Neuroradiology, American Society of Neuroradiology, 2018, 39 (4), pp.634-641. ⟨10.3174/ajnr.a5563⟩ ⟨hal-02156650⟩

2017:
Samira Mchinda, Gopal Varma, Valentin H. Prevost, Arnaud Le Troter, Stanislas Rapacchi, et al.. Whole brain inhomogeneous magnetization transfer (ihMT) imaging: Sensitivity enhancement within a steady-state gradient echo sequence. Magnetic Resonance in Medicine, Wiley, 2017, ⟨10.1002/mrm.26907⟩ ⟨hal-01657938⟩

V. H. Prevost, O. M. Girard, S. Mchinda, G. Varma, D. C. Alsop, et al.. Optimization of inhomogeneous magnetization transfer (ihMT) MRI contrast for preclinical studies using dipolar relaxation time (T1D) filtering. NMR in Biomedicine, Wiley, 2017, 30 (6), ⟨10.1002/nbm.3706⟩ ⟨hal-01657969⟩

Henitsoa Rasoanandrianina, Aude-Marie Grapperon, Manuel Taso, Olivier M. Girard, Guillaume Duhamel, et al.. Region-specific impairment of the cervical spinal cord (SC) in amyotrophic lateral sclerosis: A preliminary study using SC templates and quantitative MRI (diffusion tensor imaging/inhomogeneous magnetization transfer). NMR in Biomedicine, Wiley, 2017, 30 (12), pp.e3801. ⟨10.1002/nbm.3801⟩ ⟨hal-01657945⟩

2016:
Gopal Varma, Olivier M. Girard, Valentin H. Prevost, Aaron K. Grant, Guillaume Duhamel, et al.. In vivo measurement of a new source of contrast, the dipolar relaxation time, T1D , using a modified inhomogeneous magnetization transfer (ihMT) sequence. Magnetic Resonance in Medicine, Wiley, 2016, ⟨10.1002/mrm.26523⟩ ⟨hal-01425505⟩

Olivier M. Girard, Virginie Callot, Valentin H. Prevost, Benjamin Robert, Manuel Taso, et al.. Magnetization transfer from inhomogeneously broadened lines (ihMT): Improved imaging strategy for spinal cord applications. Magnetic Resonance in Medicine, Wiley, 2016, pp.n/a–n/a. ⟨10.1002/mrm.26134⟩ ⟨hal-01425518⟩

Valentin H. Prevost, Olivier M. Girard, Gopal Varma, David C. Alsop, Guillaume Duhamel. Minimizing the effects of magnetization transfer asymmetry on inhomogeneous magnetization transfer (ihMT) at ultra-high magnetic field (11.75 T). Magma (New York, N.Y.), 2016, 29 (4), pp.699–709. ⟨10.1007/s10334-015-0523-2⟩ ⟨hal-01425510⟩

Manuel Taso, Olivier M. Girard, Guillaume Duhamel, Arnaud Le Troter, Thorsten Feiweier, et al.. Tract-specific and age-related variations of the spinal cord microstructure: a multi-parametric MRI study using diffusion tensor imaging (DTI) and inhomogeneous magnetization transfer (ihMT). NMR in Biomedicine, Wiley, 2016, 29 (6), pp.817–832. ⟨10.1002/nbm.3530⟩ ⟨hal-01425521⟩

2015:
G. Varma, Olivier Girard, Valentin Prevost, A. K. Grant, Guillaume Duhamel, et al.. Interpretation of magnetization transfer from inhomogeneously broadened lines (ihMT) in tissues as a dipolar order effect within motion restricted molecules. Journal of Magnetic Resonance (San Diego, Calif.: 1997), 2015, 260, pp.67–76. ⟨10.1016/j.jmr.2015.08.024⟩ ⟨hal-01414326⟩

Olivier M. Girard, Valentin H. Prevost, Gopal Varma, Patrick J. Cozzone, David C. Alsop, et al.. Magnetization transfer from inhomogeneously broadened lines (ihMT): Experimental optimization of saturation parameters for human brain imaging at 1.5 Tesla. Magnetic Resonance in Medicine, Wiley, 2015, 73 (6), pp.2111–2121. ⟨10.1002/mrm.25330⟩ ⟨hal-01414354⟩

Gopal Varma, Guillaume Duhamel, Cedric Bazelaire, David C. Alsop. Magnetization transfer from inhomogeneously broadened lines: A potential marker for myelin. Magnetic Resonance in Medicine, Wiley, 2015, 73 (2), pp.614–622. ⟨10.1002/mrm.25174⟩ ⟨hal-01414328⟩

Associated Keywords

  • Inhomogenous Magnetization Transfer (ihMT)
  • MR Physics / MR Method developments
  • New Contrasts

Projects