DESROIS Martine

Research Associate (PhD)

at CNRS

CNRS researcher in the team Cardiovascular System.

Research Associate (PhD)

Detailed Activities

My work concerns cardiovascular diseases associated with vascular endothelial dysfunction. The endothelium is an important regulator of coronary vascular tone due to its ability to release potent vasoactive substances such as the vasodilators nitric oxide (NO), endothelium-derived hyperpolarizing factor (EDHF), prostacyclin (PGI2) and the potent vasoconstrictor endothelin. Endothelial dysfunction has been associated with a number of cardiovascular diseases such as atherosclerosis, hypertension, diabetes mellitus, congestive heart failure and graft vasculopathy. A disturbance of endothelial function may also contribute to the adverse effects that ischaemia and reperfusion exerts on the coronary vasculature. Endothelial dysfunction is mainly caracterized by an impaired endothelium-dependent vasodilator responses to some agonists (ACh, ADP, …) and by a reduced release of nitric oxide (NO).

My current research interests is to study endothelial dysfunction involved in ischemia related to cardiac transplantation, in type 2 diabetic heart and heart failure. Pathological heart is assessed by a metabolic study using P-31 magnetic resonance spectroscopy combined to a functional evaluation and a measure of cellular integrity (biochemical assays, High Performance Liquid Chromatography (HPLC) and Western Blotting in cardiac tissues and effluents). In addition, magnetic resonance methods (spectrometry (MRS) and imaging (MRI)) combined to biochemical and molecular biology assays furnish morphological, physiological, functional and metabolic informations to characterize the pathological heart. Studies initially performed on the isolated perfused rat heart are extent to the in situ heart in animal and then, to the pathological human heart.

I am involved in collective tasks (Gaz, animal housing facility, students training, quality management).

Keywords

  • Energy metabolism
  • Heart
  • Quantitative MRS
  • Long-term heart preservation, Heart failure
  • Endothelial dysfunction
  • Ischaemia-reperfusion injury
  • Nitric oxide (NO) pathway
  • Type 2 diabetic heart

General Information

Collaborations :
-Université Paris-Diderot, CNRS EAC 4413, Laboratoire de Biologie et Pathologie du Pancréas Endocrine (B2PE), Unité BFA, Pr J. Movassat/ Pr B. Portha.
-Université d’Avignon et des Pays de Vaucluse, Laboratoire Physiologie des adaptations cardiovasculaires à l’exercice, Dr C. Reboul.
-UNIVERSITE DE MONTPELLIER : INSERM U1046- CNRS UMR 9214, PHYMEDEXP, DR O. CAZORLA.
-University Laboratory of Physiology, Cardiac Metabolism Research Group, Oxford (UK) : Pr. K. Clarke.
-Aix-Marseille Université, UMR1062 NORT Nutrition, Obésité et Risque Thrombotique, dr E. Sérée.
-CHU d’Amiens, Département de Chirurgie Cardiaque, Pr. T. Caus.

Teaching

In parallel to my scientific activity, I am also involved in teaching (Master 1 of Pathologies Humaines (Marseille) ; students training (Masters, pHD…), college students.

Grant Supports

-Programmes D’Actions Intégrées Alliance.
-ANR COFLORES ‘IMAGERIE DE LA RESERVE CORONAIRE SANS TRAÇEURS » 2014-2017 (participant).

Publications :