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PELLETIER Jean

MD PhD
Professor in Neurology (CNU 49.01)
Department of Neurology, Timone University Hospital (APHM)
Medical School of Marseille, Neurosciences (AMU)
jean.pelletier@ap-hm.fr
tel : +33 4 91 38 59 41
fax : +33 4 91 38 62 56
Key Words
- Multiple sclerosis
- CNS demyelinating diseases
- MRI, neuropsychology
- quality of life, neuroinflammation
- neurobiology, genetics

Current Research Interest and projects

I am heading the Department of Neurology of the Timone University Hospital and the team “multiple sclerosis and CNS demyelinating” diseases of the laboratory CRMBM. The activity of the team is focused on MS and CNS demyelinating diseases. We aim at characterizing clinical and functional consequences of MS progression from the very first stage (clinically isolated syndrome (CIS)) and along the disease courses, by using innovative in vivo and non-invasive MR parameters and others non invasive approaches (electrophysiology, experimental neuropsychology). Projects
- Morphological, structural, metabolic, functional, clinical, neuropsychological and quality of life status long term follow-up patients with clinically isolated syndromes suggestive of multiple sclerosis
- Evaluation of brain plasticity efficiency in cognitive and motor systems of patients with early multiple sclerosis using repetitive transcranial magnetic stimulation (rTMS) and fMRI
- In vivo study of axonal degeneration in multiple sclerosis using cerebral sodium (23Na) Magnetic Resonance Imaging
- Modulation of the effects of TWEAK on the blood brain barrier: a new therapeutic approach to multiple sclerosis

Publications

2017

Journal Article

  • FISSOLO N., PIGNOLET B., MATUTE-BLANCH C., TRIVIÑO J. C., MIRÓ B., MOTA M., PEREZ-HOYOS S., SANCHEZ A., VERMERSCH P., RUET A., DE SÈZE J., LABAUGE P., VUKUSIC S., PAPEIX C., ALMOYNA L., TOURBAH A., CLAVELOU P., MOREAU T., PELLETIER J., LEBRUN-FRENAY C., MONTALBAN X., BRASSAT D., COMABELLA M., BIONAT, BEST-MS AND SFSEP NETWORK. “MMP9 is decreased in natalizumab-treated MS patients at risk for PML.”. Annals of Neurology [En ligne]. 6 July 2017. Disponible sur : < http://dx.doi.org/10.1002/ana.24987 > (consulté le no date)
    Résumé : OBJECTIVE: To identify biomarkers associated with the development of progressive multifocal leukoencephalopathy (PML) in multiple sclerosis (MS) patients treated with natalizumab (NTZ). METHODS: Relapsing-remitting MS (RRMS) patients who developed PML under NTZ therapy (pre-PML) and non-PML natalizumab-treated patients (NTZ-ctr) were included in the study. Cryopreserved peripheral blood mononuclear cells (PBMC) and serum samples collected at baseline, at one- and two-year treated time points, and during PML were analyzed for gene expression by RNA-sequencing and for serum protein levels by LUMINEX and ELISA assays respectively. RESULTS: Among top differentially expressed genes in the RNA-sequencing between pre-PML and NTZ-ctr patients, pathway analysis revealed a high representation of genes belonging to the following categories: pro-angiogenic factors (MMP9, VEGFA), chemokines (CXCL1, CXCL5, IL8, CCL2), cytokines (IL1B, IFNG), and plasminogen- and coagulation-related molecules (SERPINB2, PLAU, PLAUR, TFPI, THBD). Serum protein levels for these candidates were measured in a two-step manner in a screening cohort and a validation cohort of pre-PML and NTZ-ctr patients. Only MMP9 was validated and, in pre-PML patients MMP9 protein levels were significantly reduced at baseline compared with NTZ-ctr patients and levels remained lower at later time points during NTZ treatment. INTERPRETATION: The results from this study suggest that the pro-angiogenic factor MMP9 may play a role as biomarker associated with the development of PML in MS patients treated with NTZ. This article is protected by copyright. All rights reserved.
    Mots-clés : snc.


  • MAAROUF A., AUDOIN B., PARIOLLAUD F., GHERIB S., RICO A., SOULIER E., CONFORT-GOUNY S., GUYE M., SCHAD L., PELLETIER J., RANJEVA J. - P., ZAARAOUI W. “Increased total sodium concentration in gray matter better explains cognition than atrophy in MS.”. Neurology [En ligne]. 17 January 2017. Vol. 88, n°3, p. 289-295. Disponible sur : < http://dx.doi.org/10.1212/WNL.0000000000003511 > (consulté le 18 August 2017)
    Résumé : Objective: To investigate whether brain total sodium accumulation assessed by 23Na MRI is associated with cognitive deficit in relapsing-remitting multiple sclerosis (RRMS). Methods: Eighty-nine participants were enrolled in the study (58 patients with RRMS with a disease duration ≤10 years and 31 matched healthy controls). Patients were classified as cognitively impaired if they failed at least 2 tasks on the Brief Repeatable Battery. MRI was performed at 3T using 23Na MRI to obtain total sodium concentration (TSC) in the different brain compartments (lesions, normal-appearing white matter [NAWM], gray matter [GM]) and 1H- magnetization-prepared rapid gradient echo to assess GM atrophy (GM fraction). Results: The mean disease duration was 3.1 years and the median Expanded Disability Status Scale score was 1 (range 0–4.5). Thirty-seven patients were classified as cognitively preserved and 21 as cognitively impaired. TSC was increased in GM and NAWM in cognitively impaired patients compared to cognitively preserved patients and healthy controls. Voxel-wise analysis demonstrated that sodium accumulation was mainly located in the neocortex in cognitively impaired patients. Regression analysis evidenced than the 2 best independent predictors of cognitive impairment were GM TSC and age. Receiver operating characteristic analyses demonstrated that sensitivity and specificity of the GM TSC to classify patients according to their cognitive status were 76% and 71%, respectively. Conclusions: This study provides 2 main findings. (1) In RRMS, total sodium accumulation in the GM is better associated with cognitive impairment than GM atrophy; and (2) total sodium accumulation in patients with cognitive impairment is mainly located in the neocortex.
    Mots-clés : crmbm, snc.

2016

Journal Article

  • BOUTIÈRE C., REY C., ZAARAOUI W., LE TROTER A., RICO A., CRESPY L., ACHARD S., REUTER F., PARIOLLAUD F., WIRSICH J., ASQUINAZI P., CONFORT-GOUNY S., SOULIER E., GUYE M., PELLETIER J., RANJEVA J. - P., AUDOIN B. “Improvement of spasticity following intermittent theta burst stimulation in multiple sclerosis is associated with modulation of resting-state functional connectivity of the primary motor cortices.”. Multiple Sclerosis (Houndmills, Basingstoke, England) [En ligne]. 1 August 2016. Disponible sur : < http://dx.doi.org/10.1177/1352458516661640 > (consulté le no date)
    Résumé : BACKGROUND: Intermittent theta burst stimulation (iTBS) of the primary motor cortex improves transiently lower limbs spasticity in multiple sclerosis (MS). However, the cerebral mechanisms underlying this effect have never been investigated. OBJECTIVE: To assess whether modulation of spasticity induced by iTBS is underlined by functional reorganization of the primary motor cortices. METHODS: A total of 17 patients with MS suffering from lower limbs spasticity were randomized to receive real iTBS or sham iTBS during the first half of a 5-week indoor rehabilitation programme. Spasticity was assessed using the Modified Ashworth Scale and the Visual Analogue Scale at baseline, after the stimulation session and at the end of the rehabilitation programme. Resting-state functional magnetic resonance imaging (fMRI) was performed at the three time points, and brain functional networks topology was analysed using graph-theoretical approach. RESULTS: At the end of stimulation, improvement of spasticity was greater in real iTBS group than in sham iTBS group (p = 0.026). iTBS had a significant effect on the balance of the connectivity degree between the stimulated and the homologous primary motor cortex (p = 0.005). Changes in inter-hemispheric balance were correlated with improvement of spasticity (rho = 0.56, p = 0.015). CONCLUSION: This longitudinal resting-state fMRI study evidences that functional reorganization of the primary motor cortices may underlie the effect of iTBS on spasticity in MS.
    Mots-clés : connectivity, crmbm, intermittent theta burst stimulation, Multiple Sclerosis, primary motor cortex, resting state fMRI, snc, spasticity.

  • COHEN J. A., KHATRI B., BARKHOF F., COMI G., HARTUNG H. - P., MONTALBAN X., PELLETIER J., STITES T., RITTER S., VON ROSENSTIEL P., TOMIC D., KAPPOS L., TRANSFORMS (TRIAL ASSESSING INJECTABLE INTERFERON VS. FTY720 ORAL IN RRMS) STUDY GROUP. “Long-term (up to 4.5 years) treatment with fingolimod in multiple sclerosis: results from the extension of the randomised TRANSFORMS study.”. Journal of Neurology, Neurosurgery, and Psychiatry [En ligne]. May 2016. Vol. 87, n°5, p. 468-475. Disponible sur : < http://dx.doi.org/10.1136/jnnp-2015-310597 > (consulté le no date)
    Résumé : OBJECTIVE: The 12-month (M), phase 3, double-blind, randomised TRANSFORMS study demonstrated significant benefits of fingolimod 0.5 or 1.25 mg over interferon β-1a (IFNβ-1a) in patients with relapsing-remitting multiple sclerosis. We report the results of long-term (up to 4.5 years) extension of TRANSFORMS. METHODS: Patients randomised to fingolimod (0.5/1.25 mg) in the core phase continued the same dose (continuous-fingolimod) in the extension, whereas those on IFNβ-1a were re-randomised (1:1) to fingolimod (IFN-switch; IFN: 0.5/1.25 mg). Outcomes included annualised relapse rate (ARR), confirmed disability progression and MRI measures. Results are presented here for the continuous-fingolimod 0.5 mg and pooled IFN-switch groups. RESULTS: Of the 1027 patients who entered the extension, 772 (75.2%) completed the study. From baseline to the end of the study (EOS), ARR in patients on continuous-fingolimod 0.5 mg was significantly lower than in the IFN-switch group (M0-EOS: 0.17 vs 0.27). After switching to fingolimod (M0-12 vs M13-EOS), patients initially treated with IFN had a 50% reduction in ARR (0.40 vs 0.20), reduced MRI activity and a lower rate of brain volume loss. In a post hoc analysis, the proportion of IFN-switch patients with no evidence of disease activity increased by approximately 50% in the first year after switching to fingolimod treatment (44.3% to 66.0%). The safety profile was consistent with that observed in the core phase. CONCLUSIONS: These results support a continued effect of long-term fingolimod therapy in maintaining a low rate of disease activity and sustained improved efficacy after switching from IFNβ-1a to fingolimod. CLINICAL TRIAL REGISTRATION NO: NCT00340834.
    Mots-clés : snc.

  • DOCHE E., LECOCQ A., MAAROUF A., DUHAMEL G., SOULIER E., CONFORT-GOUNY S., RICO A., GUYE M., AUDOIN B., PELLETIER J., RANJEVA J. - P., ZAARAOUI W. “Hypoperfusion of the thalamus is associated with disability in relapsing remitting multiple sclerosis.”. Journal of Neuroradiology. Journal De Neuroradiologie [En ligne]. 16 November 2016. Disponible sur : < http://dx.doi.org/10.1016/j.neurad.2016.10.001 > (consulté le no date)
    Résumé : BACKGROUND: While gray matter (GM) perfusion abnormalities have been evidenced in multiple sclerosis (MS) patients, the relationships with disability still remain unclear. Considering that atrophy is known to impact on perfusion, we aimed to assess perfusion abnormalities in GM of MS patients, outside atrophic regions and investigate relationships with disability. METHODS: Brain perfusion of 23 relapsing remitting MS patients and 16 matched healthy subjects were assessed at 3T using the pseudo-continuous arterial spin labeling magnetic resonance imaging technique. In order to locate potential GM perfusion abnormalities in regions spared by atrophy, we combined voxelwise comparisons of GM cerebral blood flow (CBF) maps (cortex and deep GM) (P<0.005, FWE-corrected) and voxel-based-morphometry analysis (P<0.005, FDR-corrected) to exclude atrophic regions. Disability was assessed using the Expanded Disability Status Scale (EDSS) and the Multiple Sclerosis Functional Composite score (MSFC). RESULTS: In patients, significant GM hypoperfusion outside atrophic regions was depicted only in bilateral thalami. No other cluster was found to be hypoperfused compared to controls. Perfusion of thalami was correlated to MSFC (P=0.011, rho=0.523). A trend of correlation was found between perfusion of thalami and EDSS (P=0.061, rho=-0.396). CONCLUSION: In relapsing remitting MS, perfusion abnormalities in thalamic regions contribute to disability. These findings suggest that functional impairments of thalami, representing a major brain hub, may disturb various cerebral functions even before structural damage.
    Mots-clés : Atrophy, crmbm, Disability, Multiple Sclerosis, perfusion, Pseudo-continuous arterial spin labeling, snc, Thalamus.

  • DONADIEU M., LE FUR Y., LECOCQ A., MAUDSLEY A. A., GHERIB S., SOULIER E., CONFORT-GOUNY S., PARIOLLAUD F., RANJEVA M. - P., PELLETIER J., GUYE M., ZAARAOUI W., AUDOIN B., RANJEVA J. - P. “Metabolic voxel-based analysis of the complete human brain using fast 3D-MRSI: Proof of concept in multiple sclerosis.”. Journal of magnetic resonance imaging: JMRI [En ligne]. August 2016. Vol. 44, n°2, p. 411-419. Disponible sur : < http://dx.doi.org/10.1002/jmri.25139 > (consulté le no date)
    Résumé : PURPOSE: To detect local metabolic abnormalities over the complete human brain in multiple sclerosis (MS) patients, we used optimized fast volumic echo planar spectroscopic imaging (3D-EPSI). MATERIALS AND METHODS: Weighted mean combination of two 3D-EPSI covering the whole brain acquired at 3T in AC-PC and AC-PC+15° axial planes was performed to obtain high-quality metabolite maps for five metabolites: N-acetyl aspartate (NAA), glutamate+glutamine (Glx), choline (Cho), myo-inositol (m-Ins), and creatine+phosphocreatine (tCr). After spatial normalization, maps from 19 patients suffering from relapsing-remitting MS were compared to 19 matched controls using statistical mapping analyses to determine the topography of metabolic abnormalities. Probabilistic white matter (WM) T2 lesion maps and gray matter (GM) atrophy maps were also generated. RESULTS: Two-group analysis of variance (ANOVA) (SPM8, P < 0.005, false discovery rate [FDR]-corrected P < 0.05 at the cluster level with age and sex as confounding covariates) comparing patients and controls matched for age and sex showed clusters of abnormal metabolite levels with 1) decreased NAA (around -15%) and Glx (around 20%) predominantly in GM within prefrontal cortices, motor cortices, bilateral thalami, and mesial temporal cortices in line with neuronal/neuro-astrocytic dysfunction; 2) increased m-Ins (around + 20%) inside WM T2 lesions and in the normal-appearing WM of temporal-occipital lobes, suggesting glial activation. CONCLUSION: We demonstrate the ability to noninvasively map over the complete brain-from vertex to cerebellum-with a validated sequence, the metabolic abnormalities associated with MS, for characterizing the topography of pathological processes affecting widespread areas of WM and GM and its functional impact. J. Magn. Reson. Imaging 2016;44:411-419.
    Mots-clés : crmbm, Inflammation, Multiple Sclerosis, neurodegeneration, proton magnetic resonance spectroscopic imaging, snc, statistical mapping analysis, whole brain.

  • FAIVRE A., ROBINET E., GUYE M., ROUSSEAU C., MAAROUF A., LE TROTER A., ZAARAOUI W., RICO A., CRESPY L., SOULIER E., CONFORT-GOUNY S., PELLETIER J., ACHARD S., RANJEVA J. - P., AUDOIN B. “Depletion of brain functional connectivity enhancement leads to disability progression in multiple sclerosis: A longitudinal resting-state fMRI study.”. Multiple Sclerosis (Houndmills, Basingstoke, England) [En ligne]. November 2016. Vol. 22, n°13, p. 1695-1708. Disponible sur : < http://dx.doi.org/10.1177/1352458516628657 > (consulté le no date)
    Résumé : BACKGROUND: The compensatory effect of brain functional connectivity enhancement in relapsing-remitting multiple sclerosis (RRMS) remains controversial. OBJECTIVE: To characterize the relationships between brain functional connectivity changes and disability progression in RRMS. METHODS: Long-range connectivity, short-range connectivity, and density of connections were assessed using graph theoretical analysis of resting-state functional magnetic resonance imaging (fMRI) data acquired in 38 RRMS patients (disease duration: 120 ± 32 months) and 24 controls. All subjects were explored at baseline and all patients and six controls 2 years later. RESULTS: At baseline, levels of long-range and short-range brain functional connectivity were higher in patients compared to controls. During the follow-up, decrease in connections' density was inversely correlated with disability progression. Post-hoc analysis evidenced differential evolution of brain functional connectivity metrics in patients according to their level of disability at baseline: while patients with lowest disability at baseline experienced an increase in all connectivity metrics during the follow-up, patients with higher disability at baseline showed a decrease in the connectivity metrics. In these patients, decrease in the connectivity metrics was associated with disability progression. CONCLUSION: The study provides two main findings: (1) brain functional connectivity enhancement decreases during the disease course after reaching a maximal level, and (2) decrease in brain functional connectivity enhancement participates in disability progression.
    Mots-clés : crmbm, cvs, Disability, Functional connectivity, Functional MRI, graph theory, Multiple Sclerosis.

  • MICHEL P., BAUMSTARCK K., GHATTAS B., PELLETIER J., LOUNDOU A., BOUCEKINE M., AUQUIER P., BOYER L. “A Multidimensional Computerized Adaptive Short-Form Quality of Life Questionnaire Developed and Validated for Multiple Sclerosis: The MusiQoL-MCAT.”. Medicine [En ligne]. April 2016. Vol. 95, n°14, p. e3068. Disponible sur : < http://dx.doi.org/10.1097/MD.0000000000003068 > (consulté le no date)
    Résumé : The aim was to develop a multidimensional computerized adaptive short-form questionnaire, the MusiQoL-MCAT, from a fixed-length QoL questionnaire for multiple sclerosis.A total of 1992 patients were enrolled in this international cross-sectional study. The development of the MusiQoL-MCAT was based on the assessment of between-items MIRT model fit followed by real-data simulations. The MCAT algorithm was based on Bayesian maximum a posteriori estimation of latent traits and Kullback-Leibler information item selection. We examined several simulations based on a fixed number of items. Accuracy was assessed using correlations (r) between initial IRT scores and MCAT scores. Precision was assessed using the standard error measurement (SEM) and the root mean square error (RMSE).The multidimensional graded response model was used to estimate item parameters and IRT scores. Among the MCAT simulations, the 16-item version of the MusiQoL-MCAT was selected because the accuracy and precision became stable with 16 items with satisfactory levels (r ≥ 0.9, SEM ≤ 0.55, and RMSE ≤ 0.3). External validity of the MusiQoL-MCAT was satisfactory.The MusiQoL-MCAT presents satisfactory properties and can individually tailor QoL assessment to each patient, making it less burdensome to patients and better adapted for use in clinical practice.
    Mots-clés : snc.

  • TOURBAH A., LEBRUN-FRENAY C., EDAN G., CLANET M., PAPEIX C., VUKUSIC S., DE SÈZE J., DEBOUVERIE M., GOUT O., CLAVELOU P., DEFER G., LAPLAUD D. - A., MOREAU T., LABAUGE P., BROCHET B., SEDEL F., PELLETIER J., MS-SPI STUDY GROUP. “MD1003 (high-dose biotin) for the treatment of progressive multiple sclerosis: A randomised, double-blind, placebo-controlled study.”. Multiple Sclerosis (Houndmills, Basingstoke, England) [En ligne]. November 2016. Vol. 22, n°13, p. 1719-1731. Disponible sur : < http://dx.doi.org/10.1177/1352458516667568 > (consulté le no date)
    Résumé : BACKGROUND: Treatment with MD1003 (high-dose biotin) showed promising results in progressive multiple sclerosis (MS) in a pilot open-label study. OBJECTIVE: To confirm the efficacy and safety of MD1003 in progressive MS in a double-blind, placebo-controlled study. METHODS: Patients (n = 154) with a baseline Expanded Disability Status Scale (EDSS) score of 4.5-7 and evidence of disease worsening within the previous 2 years were randomised to 12-month MD1003 (100 mg biotin) or placebo thrice daily, followed by 12-month MD1003 for all patients. The primary endpoint was the proportion of patients with disability reversal at month 9, confirmed at month 12, defined as an EDSS decrease of ⩾1 point (⩾0.5 for EDSS 6-7) or a ⩾20% decrease in timed 25-foot walk time compared with the best baseline among screening or randomisation visits. RESULTS: A total of 13 (12.6%) MD1003-treated patients achieved the primary endpoint versus none of the placebo-treated patients (p = 0.005). MD1003 treatment also reduced EDSS progression and improved clinical impression of change compared with placebo. Efficacy was maintained over follow-up, and the safety profile of MD1003 was similar to that of placebo. CONCLUSION: MD1003 achieves sustained reversal of MS-related disability in a subset of patients with progressive MS and is well tolerated.
    Mots-clés : clinical trial, disability progression, high-dose biotin, MD1003, Multiple Sclerosis, primary progressive multiple sclerosis, secondary progressive multiple sclerosis, snc.

2015

Journal Article
KUHLE J., DISANTO G., DOBSON R., ADIUTORI CALAB anIiondADA P., SIVA A., SAIARNOLB., Sing m.LCdaptivY GROUYKOdADA QUIER P., BOYER, SAIP ZHU Y.UP. DIGHZADE, PAPEH, TULAVELOYKIND., CADVANCElife inINVESTIGATORSents wegyl an i i iv c2-year longitudinal study.”. Multiple Sclerosis (Houndmills, Basingstokto aLclert.2015. Vol. 262, n°4, p. 979-Julonibl4 sur : <3ttp:/7dx.doi657-665.1016/j.neurol.2014.09.005 > (consulté le no daS1474-4422(14)70068-r
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CAUCHETEUX N., MAAROUF A., GENEVRAY M., LEPS R., CHAUN connectiofKapITANDINULAVERICOdADA SOULAARD S.,REUTVA TINTT SOULIERPIEROCHS ORT-GOUNYLOMBOCOiimagePivY GRR A., ZAAÉ JDptivRAH A. “Criteria brain functionSH., CONFORT-nts Ton associat patientsniium sciuh tatse tingsiple Sclver the 2010 revisedultiple Sclerosis (Houndmills, Basingstoke d in R8 RRMS paMare nelstingPrital. Nog-remi a doMive ine 262, n°4, p. 979-97. Disponibl4 sur : 27ttp:/1dx.doi53-62.1007/s00415-015-7668-9 > (consulté le 3 June 2010334-013-0396-1
ED36WBQaslass="resume">Résumé : BACKGROUND: Treatment with MD1003 (high-doObjhre Sniium sciuh tatse tiost-iole CSiD1n15. nwit.ujursea stat er anth the 2010 revised criterWenosis coulic) antsniium sciuh tatse tingsiple SclverMS, know . edu48.8 ± 3.1 mmol/lS ptptissuevioldx. and pro1d010 MT2r clini-iSC " /> edu50.9 ± 2.2 mmol/lS ptptissuevioldx. = po1d0cosed criterGM010 MWMsingss=154).anSociiod sacquipp er n boliie ltiple iSC g the fostingPPMS1S). METHOss="tncritermoto id tosion.os thrtylcoien elish eienntof t ien elishinic to eetabellumctiviSP: , iSC g the fostxiQoL and SF-36. CONCahe fst-iole er:tients wimoto ish emoto id tosion.os thrtylcoien el;sh eienntof, ing tateed tov usedlcoien el;sessilesions was associhalami,patienslefc to eetabellumctAntcoicrih eienntof to demoto icoien el iSC xiQoLcoir EDSS s CONCdthan 7.0.ropoor tposedSniium sciuh tatse tiosme to MSingsiple SclverMSorics was auv-ame Strictcriteria hmoto isysleftingPPMS1-montv-amwlas68-GSStingSP: D.,asacqatientsniium sciuh tatse tapme=tsa includtudydy tharkshedermonito iS). METHODS: T dple SclverMS-clés : crmbm, cvs, Disability, Functional connectAdionr Ag.”og-mdivsacqEnl.pecorvgotienotienaMapp erBOCnairCs=154)RS and tctCnedusur Applof i Lifand)c.
ivity, than 7.0.ROTemal) aGe gnmansur, Hess=heInfrst MRctctHentstctIments / Ring-remitt> d in R8 RRMS paI whole bMal) aoiddpatAg.”owithogy, Neurosciences, Nive FiDisioloyalTrDSS tting, niv> e Sclver the 2010 revised,dSniium,dSnlidnSociegPrital.u src="plugins/auto/zotspip_spip_v1/images/zotero/attachment-web-link.png" height="16" width="16" alt="Attachment"/> PubMed entry
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KUHLE J., DISANTO G., DOBSON R., ADIUTORI MICHrLG., RBAUMSTARCC J., BOYdaptiUNT LNANDEZ,BAH FLACHrNECKdapPDA QUIER P., BOYERtin)OUdADA GHATMASCBAUN cQUIdapPDA ON BEHALF OF THE MUSIQOLlife in patients D⩾0tng Q"htt-blindLifanLand Glto E sclers). RESULtIi (consulté le 3 Jun97/MLR.000000000000011r
RDR65RK4aslass="resume">Résumé : BACKGROUND: Treatment with MD1003 (high-dose biotin):: To.e sclerria huse . Aq"htt-blindlifan(QoL) error s ="tags">R, S). METHODS: TMS xiQoLcBACKtp://cF-36 (a hg sarchhe prtop-dow .tethodrela).ce,nt er F-36 (Un pscovtsegeBths wiToeeian patc.ce,nt er toeend pobuilt scoreia h9 ditaiposed 'psysa. At leMpipQoLtaipoowitgdiv>agew er n d toeenical tlin (prun er n d jo0tng).oll3- (hiuctss="aaHOss=slasrS ttaif physis: "reas," " andorte," n d "ysi"AQoLp and Gys). RESUL n d QoLpsing xiQoLcosed cribetwe50 t le3 c.ce,nt ye and sho”.toasel. A1361 S). METHODiQoL nts wit: 87 xiQoLcBACKtp://cDS: T"ysi," 11r3cDS: T" andorte," n d 101cDS: T"reas"AQoLp and Gys patc.ce,nt er ltiple sciiocohortylprometspe watnr tosis (Mme="an 7.0. ( scorebo"> PubMed entry
BibTeX | RDR65RK4f="http://crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=mods">MODS | Refer/BibIXRDR65RK4f="http://cr//crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=rdf_bibliontology">BibRDR65RK4f="http://cr/DF | Unqualified DuRDR65RK4f="http://cr/DFZotero RDFRDR65RK4f="http://cr/DFRIS (EndNote)RDR65RK4f="http://cr//crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=wikipedia">Wikipedia CRDR65RK4f="http://cr>
RDR65RK4ail4 class="h4">2015
Journal Article
  • AJH7QIVSass="liens">
    KUHLE J., DISANTO G., DOBSON R., ADIUTORI DURANTEptiUN., CONFORT-GORICOdADA C anPYptiUNWYBRECHT DAH FAIVREdADA REUTVA TINTMALIKOVAFRANCPOMMIdapGEROCHS ORT-GOUNYLOMBOCOiimagePivY GR brain functionSHQUIER P., BOYEBOUCRAUT BOYE connectints Intrats=" pr;ynts=i ofisheaiast ond byalTrDS36 (y 50t y on MRlverwith the 2010 revised ags and SF-36. CONCsubseonandoe SLatientroposedaccr"htultiple Sclerosis (Houndmills, Basingstoke, Englans) [En ligne]. November 2016. Vol. 22, n°13, p. 1719-17Maonibl2 sur : <8ttp:/5dx.doi587-591.1007/s00415-015-7668-9 > (consulté le 3 Jute)
  • AJH7QIVSaslass="resume">Résumé : BACKGROUND: Treatment with MD1003 (high-dose biotin): Ptivst 24s and t haverd be shortedl rit intrats=" pr;ynts=i R. Exm-In MRe taseeetabvisptalicfluidnd poscotp:/d Sofished le IS1-montnr tol smerror s elatn rats=" prIgM -monIgGr;ynts=i um-e sclets r clinic linicalTri1(. = po1d0a doDS: T>ccr"httaseatientroposede with lower physical scoicdr(. = po2)17Bystetter tn o sciQundoatientsub-clus niv>werd be shortedl rit t le and relatn rats=" prIgM ;ynts=i Rod be shortesl rit t le and relatn rats=" prIgM ;ynts=i ofisheai IS1ags and SF-36. CONCsubseonandoroposedaccr"hte with lower st on100FaseoSy toe de Siceermphase MsCt ig iole randomisIgM inlow-onao pst MRe -clés : crmbm, cvs, Disability, Functional connectAdionr otienCs=15a onedivav>ivity, byalTrDS36 (Dionnais,(Dionnai> e SclonROTemal) aFrMS pctHentstctImmunoglobum.unM, Ltyle: italicS and tct> d in R8 RRMS paI whole bMal) aoiddpatAg.”ogy, Neurosciences, Ptidiemvvn V /> a. Ai MRt, Severt-bl. AIlln antIndex, Tiin Fohortt, YQungtAdionu src="plugins/auto/zotspip_spip_v1/images/zotero/attachment-web-link.png" height="16" width="16" alt="Attachment"/> PubMed entry
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    Attachment PubMed entry BibTeX | AJH7QIVSf="http://crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=mods">MODS | Refer/BibIXAJH7QIVSf="http://cr//crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=rdf_bibliontology">BibAJH7QIVSf="http://cr/DF | Unqualified DuAJH7QIVSf="http://cr/DFZotero RDFAJH7QIVSf="http://cr/DFRIS (EndNote)AJH7QIVSf="http://cr//crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=wikipedia">Wikipedia CAJH7QIVSf="http://cr> AJH7QIVSailclass="zotspip_item" style="list-style-type:none; padding-left:20px; background:url(plugins/auto/zotspip_spip_v1/images/zotero/journalArticle.png) no-repeat 0 0px;"> UZMGG5Z4ass="liens">
    KUHLE J., DISANTO G., DOBSON R., ADIUTORI FAIVREdADA RICOdADA ., CONFORT-GOC anPYptiUNREUTVA TINTWYBRECHT DAH SOULAARD S.,MALIKOVAFRANCCHS ORT-GOUNYLOMBOCOiimagePivY GRA. “Criteria brain functionSH connectints Aburdenal atientconncemvvt-blatme St1agsp. The purahe anith ent00ura the 2010 revisedultiple Sclerosis (Houndmills, Basingstoke, Englans) [En ligne]. November 2016. Vol. 22, n°13, p. 1719-17SeplefDisponi2 sur : <8ttp:/9dx.doi1251-1258.1007/s00415-015-7668-9 > (consulté le 3 Jute)
    ZMGG5Z4aslass="resume">Résumé : BACKGROUND: Treatment with MD1003 (high-doety of MD: Thenme to MSldiagnaimpoould hrmTri1owere. RESUL iQunderzotstaseatiente St/zotsocieg d worksina leaniz rece iurafunctionalent00ura the 2010 revisedulti-regiontoe="heD1S). METHODS: T00ura2-year longitudinal study.”. xiQoL nr tol s confe St/zo sociegNJ').sho prM SLldiagnscotp:/d Sot 3ci. Ding xiQoL nts withF-36 ( (S). ULtIidamenI">cestingglobstrland Glelaconncemvvt-blelaebi. d works. Pwe50 pective sn moss=154).>xiQoL an and SF-36 (Mann-Whitney U-iionctivirics was ar EDSse ships. Pwe50 e. RESUL sing (ore lower than 7.0. Sociodemograpa doM, England) FJ').sho prCnedoitterS'psyc- MSFC)r10 MglobstrRSNaconncemvvt-blxiQoL an and SF-36 (Sme=tmtherank eoir EDSse ye and shorIidamenI"> edwere1n1gtivvnlyOssir EDSS s CONCg the fodivSNaconncemvvt-blx ofaipowerdorslicfenntod oietwit d work (r = -0.811dx. = po01),1owerr d 50trlicfenntod oietwit d work (r = - 0.587dx. = po45)aar to thh eiennto-ibbr art d work (r = -0.615dx. = po33)gy and relapI caliif;" >Rod be shortesl rit e St/zo socieg d worksina leaniz iif;"igh-iagostd SF-36. CONCdthan 7.0.lent00ura the 2010 revisedus pasamfino/zonty on MRl rit e St/zo sociegNJ').sho prM SLmara2-me to MScludtudydy t15-rogater arksheelationnai,burI">-clés : crmbm, cvs, Disability, Functional connectAdionr Aaboli atlonROTemal) aHentstct> d in R8 RRMS paI whole bMal) aooto iAemvvt-bogy, Neurosciences, v class="sRusitem"> Nive Nettting, psychoof fo pri MRt, Ptidiemvvn V /> a. Ai MRt, nnces, v ge Sclon Aaboli <, v st, SensciionROSevert-bl. AIlln antIndex, YQungtAdionu src="plugins/auto/zotspip_spip_v1/images/zotero/attachment-web-link.png" height="16" width="16" alt="Attachment"/> PubMed entry
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    Attachment PubMed entry BibTeX | ZMGG5Z4f="http://crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=mods">MODS | Refer/BibIX ZMGG5Z4f="http://cr//crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=rdf_bibliontology">Bib ZMGG5Z4f="http://cr/DF | Unqualified Du ZMGG5Z4f="http://cr/DFZotero RDF ZMGG5Z4f="http://cr/DFRIS (EndNote) ZMGG5Z4f="http://cr//crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=wikipedia">Wikipedia C ZMGG5Z4f="http://cr> ZMGG5Z4ailclass="zotspip_item" style="list-style-type:none; padding-left:20px; background:url(plugins/auto/zotspip_spip_v1/images/zotero/journalArticle.png) no-repeat 0 0px;"> an37QSQass="liens">
    KUHLE J., DISANTO G., DOBSON R., ADIUTORI WYBRECHT DAH REUTVA TINT., CONFORT-GOFAIVREdADA C anPYptiUNRICOdADA MALIKOVAFRANCCHS ORT-GOUNYLOMBOSOULAARD S.,COiimagePivY GRA. “Criteria brain functionSH connectints Voxelwionetaboli
    Ran37QSQaslass="resume">Résumé : BACKGROUND: Treatment with MD1003 (high-dose biotin): Thenon 7.0.lmiscon 50tsho pruired in 38 RRMS patients crRI)iwhiedidiemgsubseonandopritalUL sthan 7.0.ln mossgnimvvn d hrioth 'phlofisheaip. The puratsoEDSS ssyndr in (CIS)a Ro nr tol s381S). METHODS: T> IS. Ato nr tclonRO10routrela381S). METHOfulfisiQoLo thoni0 tivsfodiMcDho pd's ZSNre ne critwerdia nncesrwith the 2010 revised. Exe lower than 7.0. Sociodemograp(EDSS)ae" />atlonnd poscotp:/d SolinicalTri,c100 1 to100 5,ln mossgnimvvn e" />atlonn linicalTri1-mon100 5.aT(2)"At edoM SLd poscotp:/d SolinicalTri1-mon100 1erWenuss cvoxelwionetaboli a. Aroposede a awhiedidiemgNJtss="e. RESUL sthan 7.0.rclés : crmbm, cvs, Disability, Functional connectapi&am src="plugins/auto/zotspip_spip_v1/images/zotero/attachment-web-link.png" height="16" width="16" alt="Attachment"/> PubMed entry
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    BibTeX | Ran37QSQf="http://crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=mods">MODS | Refer/BibIXRan37QSQf="http://cr//crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=rdf_bibliontology">BibRan37QSQf="http://cr/DF | Unqualified DuRan37QSQf="http://cr/DFZotero RDFRan37QSQf="http://cr/DFRIS (EndNote)Ran37QSQf="http://cr//crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=wikipedia">Wikipedia CRan37QSQf="http://cr>
    Ran37QSQailclass="zotspip_item" style="list-style-type:none; padding-left:20px; background:url(plugins/auto/zotspip_spip_v1/images/zotero/journalArticle.png) no-repeat 0 0px;"> JRNT6NJ6ass="liens">
    KUHLE J., DISANTO G., DOBSON R., ADIUTORI ., CONFORT-GOKapITANDINULAVE connectiofNAGELIERPMiUNRICOdADA MALIKOVAFRANCSOULAARD S.,VIOUTionSHCHS ORT-GOUNYLOMBOCOiimagePivY GRA. “CriteriaÉ JDptivRAH brain functionnts DiStributRe taseatientsniium sciuh tatse teoir EDSSs weachdthan 7.0.lenth the 2010 revised:eaipviss-se).sho pr23Na M atients ;" >R.ltiple Sclerosis (Houndmills, BasingstokRing-remi, n°13, p. 1719-17SeplefDisponi2 sur : 264ttp:/3dx.doi859-867.1007/s00415-015-7668-9 > (consulté le 3 Jut48/ring-r.12112680
    JRNT6NJ6aslass="resume">Résumé : BACKGROUND: Treatment with MD1003 (high-doPURPOSE: To.="h>RoaaHOapmroe CSby t le oSUL iQmtudieegra eth sG,aar twrudie tintp:/d S 3.0-T p;ih enttwo( ntmise). METHODS: TRR MS-14ODS: T00uraRR MS (tionnai,moth 'phland 5n100)aar t12gDS: T>dvaionalRR MS (tionnai,moth 'phlagd 5n100)--mon15  154)isubjhres- Q"h>dvaionalRR MSctivirics was at-the fodiTSC iDslasfGMOaaHOssir EDSS s CONCdthan 7.0.l(aHOd hrmTri s CONCt iExe lower than 7.0. Sociodemograp[EDSS]p 'psy; P = .046,Ossir ctcrTo-monr clindloadSataT2"At edotients cP = .003,Ossir ctcrTobutinotO CONCdthnnai,moth 'phlcP = .089,Ossir ctcrTanSociiod sacquipp er n boliie ltiple ss="tncriiSC g the fostinslasfdex atienslef,neetabellumocar toisicotude dl CONCdthan 7.0.roBtientsniium M atients marahelptmonito ithena statuniv fptissuev.ujurse10 Mmogan 7.0.rclés : crmbm, cvs, Disability, Functional connectAdionr Ahe Ulowr Curvpctotienivity, than 7.0. E" />atlonROTemal) aHentstctI whe E sclerrovectI whe Ii d in R8 RRMS paI whole bMal) aoiddpatAg.”ogy, Neurosciences, v class="sRusitem"> v ge Sclon Aaboli <, Sniium,dSociiod ss, Nond o_setricm src="plugins/auto/zotspip_spip_v1/images/zotero/attachment-web-link.png" height="16" width="16" alt="Attachment"/> PubMed entry
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    Attachment PubMed entry BibTeX | JRNT6NJ6f="http://crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=mods">MODS | Refer/BibIXJRNT6NJ6f="http://cr//crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=rdf_bibliontology">BibJRNT6NJ6f="http://cr/DF | Unqualified DuJRNT6NJ6f="http://cr/DFZotero RDFJRNT6NJ6f="http://cr/DFRIS (EndNote)JRNT6NJ6f="http://cr//crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=wikipedia">Wikipedia CJRNT6NJ6f="http://cr> JRNT6NJ6ail4 class="h4">2015
    Journal Article
  • 6VTF6QITass="liens">
    KUHLE J., DISANTO G., DOBSON R., ADIUTORI C anPYptiUN., CONFORT-GOLEMAIREPMiUNRICOdADA FAIVREdADA REUTVA TINTMALIKOVAFRANCCHS ORT-GOUNYLOMBOCOiimagePivY GRA. “Criteria brain functionSH connectints Ptival)niv fpge gnmansuririchniv-ament00ura the 2010 revisedo an and Sbyruired iz trtstniv th 'p1tients .ltiple Sclerosis (Houndmills, BasingstokPloS ok=, n°13, p. 1719-17/h51 sur : 6ttp:/9dx.doie2496r.1007/s00415-015-7668-9 > (consulté le 3 Ju371/
    6VTF6QITaslass="resume">Résumé : BACKGROUND: Treatment with MD1003 (high-doThenosia. At ildiagnd pooulic) antt imtival)niv,itwerdiStributRe tar to thholoctgra dthan 7.0.l fpge gnmansuri(GM)irichniv-ament00ura the 2010 revised. E y-t dS). METHODS: T> p. The puratsoEDSS ssyndr in DS: T> reas risktdsis: T er the 2010 revisedoxiQoL nr tol s cot ildiagofFo y-finpohGSlthygss=154).> a(pand 0.05 FDR) criwcrmh"una positive dlc.ce,nt015-vie CSwheipined o36 (ybi.  154)iterihoLwhnie( 154)imop tatse . Uscoreia PubMed entry
    Attachment PubMed entry
    BibTeX | 6VTF6QITf="http://crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=mods">MODS | Refer/BibIX6VTF6QITf="http://cr//crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=rdf_bibliontology">Bib6VTF6QITf="http://cr/DF | Unqualified Du6VTF6QITf="http://cr/DFZotero RDF6VTF6QITf="http://cr/DFRIS (EndNote)6VTF6QITf="http://cr//crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=wikipedia">Wikipedia C6VTF6QITf="http://cr>
  • 6VTF6QITailclass="zotspip_item" style="list-style-type:none; padding-left:20px; background:url(plugins/auto/zotspip_spip_v1/images/zotero/journalArticle.png) no-repeat 0 0px;"> IU6EDTJXass="liens">
    KUHLE J., DISANTO G., DOBSON R., ADIUTORI REUTVA TINT., CONFORT-GOC anPYptiUNFAIVREdADA RICOdADA MALIKOVAFRANCCHS ORT-GOUNYLOMBOCOiimagePivY GR brain functionSHQUIER P., BOYE connectints Csgnimvvn holoirroved t t ionsetrwith the 2010 revised:ar EDSse shipstoOroposedlocatlonultiple Sclerosis (Houndmills, Basingstoke, Englans) [En ligne]. November 2016. Vol. 22, n°13, p. 1719-17June7/h51 sur : 17ttp:/6dx.doi755-758.1007/s00415-015-7668-9 > (consulté le 3 Jute)
    IU6EDTJXaslass="resume">Résumé : BACKGROUND: Treatment with MD1003 (high-doThenholoctgrisroposedlocatlonne teognimvvn NJ').shocoreaaHOaan and S conf mis97dS). METHODS: T> p. The puratsoEDSS ssyndr in.rUscoreia hBoief R8me="ans="Bansurgv>werfunctional rit 24%tmise). METHOltiple adoroa onori1-bnp://lriion,7/h% adoroa ontwo(-mon15% adoroa ontetae suerbstrlaarocorescotp:/a>cestxiQoL nverseiagostd SF-36. CONCme to c a. Aroposede coBroca'HOaGGS,s cot ir dNenntof lobe1-montn o thaSle">um whtlthaS). ULtlaarocorescotp:/a>cestxiQoL nverseiagssir EDSS sterihoLme to c a. Aroposede cot ideeppwhtter ansuranNoO and SF-ip_stxiQoLfunctional. Pwe50 aposedlocatlonn dozcotp:/a>ce . Atasks e loo36 (ansuntlonn doexecumvvn NJ').shosrclés : crmbm, cvs, Disability, Functional connectAdionr Ansuntlonr otienCnairCs=154)RS and tctCngnimvonROCngnimvon007/ordersv>ivity, byalTrDS36 (Dionnais,(Dioan 7.0. E" />atlonROExecumvvn FJ').shoROTemal) aFrMS pctHentstct> d in R8 RRMS paI whole bMal) aoemorbogy, Neurosciences, ing, psychoof fo pri MRt, Ptival)niv,iSptaliciv-d,suerbstrLaarocor, YQungtAdionu src="plugins/auto/zotspip_spip_v1/images/zotero/attachment-web-link.png" height="16" width="16" alt="Attachment"/> PubMed entry
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    Attachment PubMed entry BibTeX | IU6EDTJXf="http://crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=mods">MODS | Refer/BibIXIU6EDTJXf="http://cr//crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=rdf_bibliontology">BibIU6EDTJXf="http://cr/DF | Unqualified DuIU6EDTJXf="http://cr/DFZotero RDFIU6EDTJXf="http://cr/DFRIS (EndNote)IU6EDTJXf="http://cr//crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=wikipedia">Wikipedia CIU6EDTJXf="http://cr> IU6EDTJXailclass="zotspip_item" style="list-style-type:none; padding-left:20px; background:url(plugins/auto/zotspip_spip_v1/images/zotero/journalArticle.png) no-repeat 0 0px;"> A3C5HNB7ass="liens">
    KUHLE J., DISANTO G., DOBSON R., ADIUTORI REUTVA TINT., CONFORT-GOC anPYptiUNFAIVREdADA RICOdADA MALIKOVAFRANCSOULAARD S.,VIOUTionSH brain functionSHQUIER P., BOYE connectints Freonanc.lmiscognimvvn holoirroveddrat MRc purat the fost with lower st on5n100Fasestudy.”.
    A3C5HNB7aslass="resume">Résumé : BACKGROUND: Treatment with MD1003 (high-doPtivst 24s and t haverd be shortedl rit cognimvvn holoirrovededo lGGSSZnme to MSiD1S). METHOsuffheth lientsaip. The puratsoEDSS ssyndr in (CIS)ay on MRlverwith the 2010 revised crit. However, 1tffidedoknownn boutrt iepu. Blmiscognimvvn holoirrovedofished lea statuniv fp> IS. In orderrtoOihaoacteriicto th00uraevolutRe tasecognimvvn holoirrove,itwer alhorHOaan and S with la 5-100 physical scoicdrnf mis24i IS1S). METHODS: Treas risktelatsis: T er MS. Ltyle: italicnng, psychoof fo pr an anrandod poscotp:/d Solitwo(tiin poived cnicalTri1-mon100 5)SiD1S). METHOn moss=154).>cnicalTri1-mon100 1). Ato100 5,l54%tmise). METHOltiple cognimvvn holoirrovedogiensl 29%SolinicalTri.ogy, Neurrege Sclon unid Glltiple rit S). METHODS: T> reaserrT(2)oroposedloadSolinicalTri1hadT> reaserrssgnimvvn holoirroved t 100 5.aTa Roscotp:/d SaipCISse). METHOltiple rit t lefreonanc.lmiscognimvvn holoirrovedt the fost rat MRc pura with lower st on5n100F physith la IS1-mon rit t lecognimvvn sociode t 100 5od posdidiemans="byscon 50tsho prM SLd o_setersinacordedSolinicalTri-clés : crmbm, cvs, Disability, Functional connectAdionr otienCsgnimvon007/ordersv>ivity, byalTrDS36 (Dionnais,(Dioan 7.0. E" />atlonRODionnai> e SclonROTemal) aHentstctLtyle: italicS and tct> d in R8 RRMS paI whole bMal) aogy, Neurosciences, ing, psychoof fo pri MRt, O17oclho prB-mos, visktFohortt, Sptaliciv-du src="plugins/auto/zotspip_spip_v1/images/zotero/attachment-web-link.png" height="16" width="16" alt="Attachment"/> PubMed entry
    BibTeX | A3C5HNB7f="http://crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=mods">MODS | Refer/BibIXA3C5HNB7f="http://cr//crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=rdf_bibliontology">BibA3C5HNB7f="http://cr/DF | Unqualified DuA3C5HNB7f="http://cr/DFZotero RDFA3C5HNB7f="http://cr/DFRIS (EndNote)A3C5HNB7f="http://cr//crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=wikipedia">Wikipedia CA3C5HNB7f="http://cr>
    A3C5HNB7ailclass="zotspip_item" style="list-style-type:none; padding-left:20px; background:url(plugins/auto/zotspip_spip_v1/images/zotero/journalArticle.png) no-repeat 0 0px;"> C9P2DZE6ass="liens">
    KUHLE J., DISANTO G., DOBSON R., ADIUTORI RICOdADA ., CONFORT-GOFRANQUES BOYE TTARIANULAVEREUTVA TINTMALIKOVAFRANCCHS ORT-GOUNYLOMBOSOULAARD S.,POUGET BOYECOiimagePivY GRA. “Criteria brain functionSH connectints ooto icf="fo prna leaniz iifme to MScfisheaiscorrapancbikrwith the 2010 revised tsitoglmisco="foo-sptalicdysNJ').shoultiple Sclerosis (Houndmills, Basingstokeagma (New York, i.Y.2, n°13, p. 1719-17Aprilponi1 sur : 24ttp:/2dx.doi77-84.1007/s00415-015-7668-9 > (consulté le 3 Ju00 /s10334-ni0-0232-r
    C9P2DZE6aslass="resume">Résumé : BACKGROUND: Treatment with MD1003 (high-doety of: Whtltha statuniv fpmoto icf="fo prna leaniz h pobe50 e.00urad be shortedliD1S). METHODS: Th the 2010 revised crit, iededonotOyet e.00rwheowe:sia shollsfmoveroved . AthoLick-domtal MSh-montnduonalrecruitrandomisthoLnn hriot cth tate cf="hxa(BA32) usu purat iole CSiD1inedlexruoto imoveroved.aTa crmbm, cvs, Disability, Functional connectAdionr otienaMapp erBOivity, byalTrDS36 (Dionnais,(Eitkd SPosuntla). aooto ROTemal) aHentstct> d in R8 RRMS paI whole bMal) aoiddpatAg.”ooto iAemvvt-booto iCf="hx, ogy, Neurosciences, Pyramid prioacts, YQungtAdionu src="plugins/auto/zotspip_spip_v1/images/zotero/attachment-web-link.png" height="16" width="16" alt="Attachment"/> PubMed entry
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    Attachment PubMed entry BibTeX | C9P2DZE6f="http://crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=mods">MODS | Refer/BibIXC9P2DZE6f="http://cr//crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=rdf_bibliontology">BibC9P2DZE6f="http://cr/DF | Unqualified DuC9P2DZE6f="http://cr/DFZotero RDFC9P2DZE6f="http://cr/DFRIS (EndNote)C9P2DZE6f="http://cr//crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=wikipedia">Wikipedia CC9P2DZE6f="http://cr> C9P2DZE6ailclass="zotspip_item" style="list-style-type:none; padding-left:20px; background:url(plugins/auto/zotspip_spip_v1/images/zotero/journalArticle.png) no-repeat 0 0px;"> QD7G2BJ3ass="liens">
    KUHLE J., DISANTO G., DOBSON R., ADIUTORI ., CONFORT-GOC anPYptiUNRICOdADA FAIVREdADA SOULAARD S.,COS ORT-GOUNYLOMBOCOiimagePivY GRA. “Criteria brain functionSHKAPHAND S., connectints Iirvivo.="h>T" c Cultiple Sclerosis (Houndmills, Basingstokeo hr tarrgend inHOn momcriboackm, n°13, p. 1719-17June7/h51 sur : 103,Op:/2dx.doi138-141.1007/s00415-015-7668-9 > (consulté le 3 Ju016/<.ymgme.oni1 02.013
    QD7G2BJ3aslass="resume">Résumé : BACKGROUND: Treatment with MD1003 (high-doDsis: Trandomis15-rogatermarkersiedonec anarseoulic) antt imosuntla)r0fficac.lmisnewnowe:apeu inHO coNiemann-PickODionnai>T" c C (NP-C).tivityenme to MSldiagv>uired iz trtstniv th 'p1(MTR)1tients , a.="h>to.="h>Rod be shortest rit positive dlatient cjurser EDSS stere. RESUL seficitnve abdraan and S covivo. condion NP-CaF-36 (MTRltients . AlthougNCme liminargv>t onefinonngnty on MRl rit MTRltients marabdr="pllane dlc-moipi-i critwerdsis: TrandomisbiomarkerO coNP-Caclés : crmbm, cvs, Disability, Functional connectAdionr oioof fo prMarkersr otienaIcjuriosROTemal) aHentstct> d in R8 RRMS paI whole bMal) aoiddpatAg.”Niemann-PickODionnai,>T" c C, YQungtAdionu src="plugins/auto/zotspip_spip_v1/images/zotero/attachment-web-link.png" height="16" width="16" alt="Attachment"/> PubMed entry
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    Attachment PubMed entry BibTeX | QD7G2BJ3f="http://crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=mods">MODS | Refer/BibIXQD7G2BJ3f="http://cr//crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=rdf_bibliontology">BibQD7G2BJ3f="http://cr/DF | Unqualified DuQD7G2BJ3f="http://cr/DFZotero RDFQD7G2BJ3f="http://cr/DFRIS (EndNote)QD7G2BJ3f="http://cr//crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=wikipedia">Wikipedia CQD7G2BJ3f="http://cr> QD7G2BJ3ailclass="zotspip_item" style="list-style-type:none; padding-left:20px; background:url(plugins/auto/zotspip_spip_v1/images/zotero/journalArticle.png) no-repeat 0 0px;"> HGHTCEJUass="liens">
    KUHLE J., DISANTO G., DOBSON R., ADIUTORI ., CONFORT-GOREUTVA TINTRICOdADA FAIVREdADA C anPYptiUNMALIKOVAFRANCSOULAARD S.,VIOUTionSHLE FUR YANCCHS ORT-GOUNYLOMBOCOiimagePivY GRA. “Criteria brain functionSH connectints O statuniv fpn15. nwitdysNJ').shoh with lower st on5 100Fasestudy.”.
    HGHTCEJUaslass="resume">Résumé : BACKGROUND: Treatment with MD1003 (high-dootienan15. nwit cjurse snme to MSiD1S). METHOsuffheth lientsh the 2010 revised critiientsthoL00uie onwitgdrwittwerdiSnnai; however,ower J').sholiccoui RoaaHOoulic) antt imosuntla)rholoctgris00uran15. nwitdysNJ').shohnonectth lDhtter ansur (WM),pge gnmansuri(GM)ROo t ieetabellumte teognimvvn d hrioratlon -mo/o EDSSLp e Sclont with lower st on5n100FaseMS. Mired in 38 RRMS paspechigscopin (MRitiexamTrDS3e sn monng, psychoof fo pr an anrandMS patiscotp:/d SiD1231S). METHO nr tol sofished le st one. RESUL ancbikrwitMS a do24ohGSlthygss=154).anThenlamens, tocol d poscotp:/d SingS). METHOnfisheai physical wit5n100. Mcriboaccan15. nwitNJ').shohaaHOaan and S coWM (aSle">um misco=pusSo ploh M)ROGM (dorslicpos hriot cth tate cf="hx),tar to theetabellumtbraev />atlh lN-aceoidaspotsate (NAA) land G.crmeth liphysical, 39%tmise). METHOltiple cognimvvn d hrioratlon -mo 43%Oltiple a d hrioratlon ingthoi EDSS. P). METHODS: Tpognimvvn d hrioratlon hadT e aisheNAArland tredu).shos with lfphysical cot ieetabellum (p = po03)ia doWM (p = po2)Sined overtoOS). METHODS: outrcognimvvn d hrioratlonutiviuto/tlonROp). METHODS: Tpognimvvn d hrioratlon hadTreaserrp e Sclont. Ai2oroposedloadS(T2LL)t with lower physical scoicdrined overtoOS). METHODS: outrcognimvvn d hrioratlon (p = po3)anNoO(iffhe">ces . Pwe50 S). METHODS: T>ndODS: outrEDSSLp e Sclont cotermFaseNAArland deorrT2LL xiQoLsitive CanThenme to MSstyle: italic;" >Rofes/zoeunctionl rit,t with lower st on5n100FaseMS,rcognimvvn d hrioratlon edo and SF-36. CONCtyenme e Sclont. An15. nwitdysNJ').shohnr toissuev.ujurse1do an and SbyrMRio-monT2LL,fe Specttnd .rclés : crmbm, cvs, Disability, Functional connectAdionr Aszotspc AcidCsgnimvon007/ordersv>ivity, ionnai> e SclonROTemal) aHentstct> d in R8 RRMS paSpechigscopy bMal) aogy, Neurosciences, ing, ns, ing, psychoof fo pri MRt, YQungtAdionu src="plugins/auto/zotspip_spip_v1/images/zotero/attachment-web-link.png" height="16" width="16" alt="Attachment"/> PubMed entry
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    Attachment PubMed entry Attachment PubMed entry BibTeX | HGHTCEJUf="http://crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=mods">MODS | Refer/BibIXHGHTCEJUf="http://cr//crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=rdf_bibliontology">BibHGHTCEJUf="http://cr/DF | Unqualified DuHGHTCEJUf="http://cr/DFZotero RDFHGHTCEJUf="http://cr/DFRIS (EndNote)HGHTCEJUf="http://cr//crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=wikipedia">Wikipedia CHGHTCEJUf="http://cr> HGHTCEJUail4 class="h4">2015
    Journal Article
  • 7X74RAVMass="liens">
    KUHLE J., DISANTO G., DOBSON R., ADIUTORI connectiA ., CONFORT-GOREUTVA TINTRICOdADA MALIKOVAFRANCCHS ORT-GOUNYLOMBOCOiimagePivY GRA. “Criteria brain functionnts Ar/sphgnmainlyOnonectsfdex limbrmbsysleftar to thdeeppge gnmansurd t t i st onwitgdrwitstudy.”.
    7X74RAVMaslass="resume">Résumé : BACKGROUND: Treatment with MD1003 (high-dooACKGROUNDseT exlsonniv fpge gnmansuri(GM)iar/sphgnr dofished le st one. RESUL evo MSl on MRlverwith the 2010 revised crit"plmainsgss=154vers4al.oThenosia. At eif;" >RoaaHOoclaefv-amto MRansishrwheowe:sreg UL GM -r/sphgnedo lGGSSZnme to MSiD1thoL00uie onwitgdrwitMSh an anth lreg UL GM -r/sphgneconflargef misS). METH. ti-regionSixty-two1S). METHODS: T> p. The puratsoEDSS ssyndr in (CIS)axiQoLfxamTrS shohn 1.5 T MRltiene:sDS: eco6 mnnthsdofished lpip st one. RESUL evo Ms. A mis37 man clmohGSlthygss=154)isubjhresoxiQoL nts. nr tol s cot ildiagofAa optimislmovoxe., fodimosphome-ri (VBM)imcrho customislmo criMShaaHOapmlil shohvolume-rrmbT(1)"At l s .oThen J').sholicsociodemise). METHOaaHOaan and Suscoreia hhre lowerDioan 7.0. SociodeSSULn (EDSS)tar to thBoief R8me="ans="Bansurgye and shorVBM n boliie (pand 0.005, famTlywioneerro icf=rhrets) o0 S). METHOversusgss=154)isubjhresoltiple roLme to c a. A positive dlfoe p GM -r/sphgnecoS). METHO niolecoreia hn 7aishwit cbr a,eia hn 7aishwitorbitoNenntof cf="ices,eia hn 7aishwitii d in R8 RRMS paI whole bMal) aoiddpatAg.”ogy, Neurosciences, Sever.0.l fpIlln antIlowx, YQungtAdionu src="plugins/auto/zotspip_spip_v1/images/zotero/attachment-web-link.png" height="16" width="16" alt="Attachment"/> PubMed entry
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    Attachment PubMed entry Attachment PubMed entry BibTeX | 7X74RAVMf="http://crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=mods">MODS | Refer/BibIX7X74RAVMf="http://cr//crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=rdf_bibliontology">Bib7X74RAVMf="http://cr/DF | Unqualified Du7X74RAVMf="http://cr/DFZotero RDF7X74RAVMf="http://cr/DFRIS (EndNote)7X74RAVMf="http://cr//crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=wikipedia">Wikipedia C7X74RAVMf="http://cr>
  • 7X74RAVMailclass="zotspip_item" style="list-style-type:none; padding-left:20px; background:url(plugins/auto/zotspip_spip_v1/images/zotero/journalArticle.png) no-repeat 0 0px;"> STG8P37Cass="liens">
    KUHLE J., DISANTO G., DOBSON R., ADIUTORI JUREptiUN., CONFORT-GOROUSSEAU C-GOREUTVA TINTRICOdADA MALIKOVAFRANCCHS ORT-GOUNYLOMBOCOiimagePivY GRA. “Criteria brain function., connectints Ii, Did"htovoxe., fodin boliie aseatientuired iz trtstniv uipss })sT e aif" rian 7.0. fpgeagnmansuri cjurse cot i st onwitgdrwitstudy.”.
    STG8P37Caslass="resume">Résumé : BACKGROUND: Treatment with MD1003 (high-doInTh the 2010 revised crit, iedseems 1keura rit t le" rian 7.0. fptwerlizottermatthan 7.0.lm dbe/zotsura westerihoL" rian 7.0. fptwer00urageagnmansuri(GM)i cjurs.tivityenme to MSldiagv>wdraan and SihoL" rian 7.0. fpGMi cjurse co00uraMS,ruscoreaimcrho de posvertoOd hrmTrSntnd Did"htorichniv- sacqGMipansurns. E l50 S). METHOme to Mth lDS: T> p. The puratsoEDSS ssyndr in a do24ohGSlthygman clmoss=154)isubjhresoxiQoL nr tol s cot eif;" >R. P). METHODiQoLfxlood Suscoren 1.5 Tesc="MR10 annuri(> d om ViclontPlus; Sierovs). otienaMRns, tocol nr tol suired iz trtstniv th 'p1tients (MTR)anSociiod sacquipp er n bolieMS patiscotp:/d StoOined ovaebi. subjhre'sqGMiMTRluipss CONCt ose . Atwerwhnief misss=154)isubjhreso(SPM5)anThenlociiod sacqteta }ldoaaHOoak50 todbe/t imaximum Pf" /> s }) er una positive dlr ts hrrwheohnrygss=154)itnd Did"htoaaHOssed over CONCtwerwhniefss=154)ipopulatlonutGM -bnp://litieMS patisitive CSena83% . Atwere). METHv>rtsgth liD1size ients0.3 tod125 cm(3)anAbe gntwere). METHr CONCGM -bnp://litieM, 87%1hadT>bnp://litieMSlocatnal cot io crmbm, cvs, Disability, Functional connectAdniesc50t,tAdionr otienotienaMapp erBOCnairCs=154)RS and tctivity, iireood saI whole b ionnai> e SclonROTemal) aHentstctI whe c anth Csm9ARer-Aants hdct> d in R8 RRMS paI whole bMal) aoiddpatAg.”ogy, Neurosciences, Res, ducin 7.0. fpRebr cnu src="plugins/auto/zotspip_spip_v1/images/zotero/attachment-web-link.png" height="16" width="16" alt="Attachment"/> PubMed entry
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    BibTeX | STG8P37Cf="http://crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=mods">MODS | Refer/BibIXSTG8P37Cf="http://cr//crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=rdf_bibliontology">BibSTG8P37Cf="http://cr/DF | Unqualified DuSTG8P37Cf="http://cr/DFZotero RDFSTG8P37Cf="http://cr/DFRIS (EndNote)STG8P37Cf="http://cr//crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=wikipedia">Wikipedia CSTG8P37Cf="http://cr> STG8P37Cailclass="zotspip_item" style="list-style-type:none; padding-left:20px; background:url(plugins/auto/zotspip_spip_v1/images/zotero/journalArticle.png) no-repeat 0 0px;"> A5WI2KZ5ass="liens">
    KUHLE J., DISANTO G., DOBSON R., ADIUTORI ., CONFORT-GORICOdADA connectiA REUTVA TINTMALIKOVAFRANCSOULAARD S.,VIOUTionSHLE FUR YANCCHS ORT-GOUNYLOMBOCOiimagePivY GRA. “Criteria brain functionnts Unf}ldcoreia hlizottermarichnphysioof fo prp c aneF physith laohncARes cflam//corRod byalTrDS36 (roposedwitstudy.”. (consulté le 3 Ju016/<.mri.2n09.12.011
    A5WI2KZ5aslass="resume">Résumé : BACKGROUND: Treatment with MD1003 (high-dooACKGROUNDseAcARessymptot MRcs cflam//clon edo omain fe="urerwith the 2010 revised butarichnphysioof fo prp c aneFunI"rlycoreiotwitor/zotsplicrecovery> ovapooruraulderstood. ety ofIVE: ToOihaoacterizeS covivo.t onep c aneF="imo hr tar, structurlic-mo J').sholicland deuscoreh theuni prMRimcrhoH. ti-regionAAneg, tients 3-100 physical (Weeks 0, 3, 11, 29, 59c-mo 169)oaaHOssnduotd Soconf41-100-}ldoaot nOme to Mth lolinicalTri1DS: T> largefncAResd byalTrDS36 (roposedwitstudy.”. uired iz trtstniv tients , diffua "At l s ts , J').sholicM SL ndrmired in 38 RRMS paspechigscopyS patissnduotd Soli1.5 Tye and shorP). METOme to Mth lDS: TsubncAResspip my.giacrecovernals e Sclnd . (e elowertthan 7.0.lsociodesSULn 7 tod5.5)anThenMRifxloo d be shortedlstructurlic J').sholicn momcriboacc holoirrovesSolinicalTri.Debr tnerebtoo . Atwerbloodeatientbarriuri ctegrt-breas lactaResspnd depers4stlmo criseverhtoaeeks ssncomBasETs CONCglplicnemvv . Sysi> doz e Sclnd structurlic-mo mcriboacc rebtoo sha statud ientsnicalTri1todW169 (roposedvolume -64%;Oapmae">uired iz trtstniv th 'p1+14%v>chooTri1-51%, 1pids -78%,N-aceoidaspotsate +77%)Owhtlen J').sholi.0. fptweruoto isysleftrecovernaye and relaphorM theuni prMRI/MRiofunctionallizottermatyp_sinHOrecovery>p c aneF niolecoreiissueve d ir, glplicnemvv ,Orecovery>. An15. nwitNJ').shohnr t J').sholicsyslefd.aTa crmbm, cvs, Disability, Functional connectAcAResDionnai,>Adionr otienTemal) aHentstctIcflam//clonct> d in R8 RRMS paI whole bMa d in R8 RRMS paSpechigscopy bMgy, Neurosciencesu src="plugins/auto/zotspip_spip_v1/images/zotero/attachment-web-link.png" height="16" width="16" alt="Attachment"/> PubMed entry
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    Attachment PubMed entry Attachment PubMed entry Attachment PubMed entry BibTeX | A5WI2KZ5f="http://crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=mods">MODS | Refer/BibIXA5WI2KZ5f="http://cr//crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=rdf_bibliontology">BibA5WI2KZ5f="http://cr/DF | Unqualified DuA5WI2KZ5f="http://cr/DFZotero RDFA5WI2KZ5f="http://cr/DFRIS (EndNote)A5WI2KZ5f="http://cr//crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=wikipedia">Wikipedia CA5WI2KZ5f="http://cr> A5WI2KZ5ail4 class="h4">2015
    Journal Article
  • 795QK2WDass="liens"> KUHLE J., DISANTO G., DOBSON R., ADIUTORI A. “Criteria connectiA REUTVA TINT brain func“PSONticitse coMhorientsFJ').sholicIients wamuehan 7.0 ultiple Sclerosis (Houndmills, BasingstokIi
    795QK2WDaslass="resume">Résumé : BACKGROUND: Treatment with MD1003 (high-doOne . Atwermain ihaoacteris inHOwith the 2010 revised crit"is ower0xlsonniv fpa "p. The" nadioof fo prpaoadtspanThen;" ce d ncieMSsitive CS. Pwe50 t lec. RESUL ar tnadioof fo prfinonngntm dbe/zotsura="1ribu"ans="wamlbikrwitspecificitse. Atwertients mnnaur tctbuta nts.wam J').sholicna leaniz mechanismsha statth lolinoONCtweratientar tsptaliccord land G.cT onenng, pSONtic>p c aneFm dp uncteaimcanHOwitdeonCth lt ie. RESUL expe Sclont. As in J').sholicsymptotsusFJ').sholicM SL(fM S)imcrhosdp uncteaiusef stmcanHOwitde hrmTrth lDheowe:s J').sholicna leaniz mechanismsha At eifki mo QoL trwo.k. IMSh-srbe50 fMRansishd ,o crifxampl) a rit t lonenng, pSONtic>mechanismsha staSr dientsthoLMRatstaset lediSnnaiL ndrmiygss=15ibu"="wamredu)th lt iexpe Sclont. AthoLMymptotserebr cth lientsrichniv- sacqtissue,ma whe.aTa PubMed entry
    BibTeX | 795QK2WDf="http://crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=mods">MODS | Refer/BibIX795QK2WDf="http://cr//crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=rdf_bibliontology">Bib795QK2WDf="http://cr/DF | Unqualified Du795QK2WDf="http://cr/DFZotero RDF795QK2WDf="http://cr/DFRIS (EndNote)795QK2WDf="http://cr//crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=wikipedia">Wikipedia C795QK2WDf="http://cr>
  • 795QK2WDailclass="zotspip_item" style="list-style-type:none; padding-left:20px; background:url(plugins/auto/zotspip_spip_v1/images/zotero/journalArticle.png) no-repeat 0 0px;"> RMKU2SN9ass="liens">
    KUHLE J., DISANTO G., DOBSON R., ADIUTORI REUTVA TINT connectiA RICOdADA MALIKOVAFRANC brain function.,A. “Criterc“[Cognimvvn holoirrove]ultiple Sclerosis (Houndmills, BasingstokRevueAneg, iv-idet, n°13, p. 1719-17Mari. on09 sur : 165 Supml 4dx.doiS113-122.1007/s00415-015-7668-9 > (consulté le 3 Ju016/S0035-3787(09)72122-8
    RMKU2SN9aslass="resume">Résumé : BACKGROUND: Treatment with MD1003 (high-doCognimvvn holoirroveFiscommont coh the 2010 revised crit, a statth loli puawitgdstaset lediSnnai, evo d t t i00uie oct ndrve abdra majo isins/auelatthan 7.0., nd SFl holoirrovect ndri/lover.shd ="htttse. Attpe.oCognimvvn dysNJ').shoh ssnceptulicnaaip_ole bverb prf/> nc., nped Soist-tp://cshohp c anth ansun.shohnr texecumvvn NJ').sho. Mcnaur tSoist-tp://csho-p c anth nped Sopp00 todbe/t imost robusl ar tsaipomvvn markersimisssgnimvvn holoirroveFinaMSse). METH.oCognimvvn t MRlh liD1MSse). METHOiscom 20xt ndrvognimvvn screents wesesSo-amtime-t ndrvokgroavts weset cbtretails. A com rehaipove ar tsaipomvvn cognimvvn t MRhp c durer }uldabdradmTrts hrvertoOd hctrcognimvvn dysNJ').shoct ndrreco MSldiaiost be shortet rit pngl) ape domTrDnsuranped -r EDSS scognimvvn t MRs marabdrsuphriot oolextaipove ar ttime- nr tots diSnnaiLcinsai, f). guect ndrnonecttvlediSturb nce,rve aholoctgt idsgreerwitMS-r EDSS scognimvvn holoirrove.Debr tneweakgssir EDSshos CONCdiSnnaiLduratlon -mo physiSUL sthan 7.0.lsociod,gt idsgreerwitssgnimvvn holoirroveFinaMSsh-srbe50 r EDSS sterower0xtaitnasetoptp://crm puraspecificln15. nwittissue,ma whee-monross. NetagessSldiaiosthaverapmlil scvn 50tsho pr-mon="h>rwitMRI-vis415-0roposed dotsSnot NJpuraaccoui critwerdsgreerwitMS-r EDSS scognimvvn holoirrove.Nsncon 50tsho prM SLfinonngnty on MRl rer0xtaitnasesubts="wissue,ma wheeenanp://l-opp00th lDhtter-mongeegnmansuritoOinir EDSSCb MRl CONCtwersever.0.l fpssgnimvvn holoirroveFinaMSse). METH.oStructurlicM SL pp bi.eMShaverreco Msrabd50 fxtaidd Sbyr J').sholicM SLldiaiostscrumvnizcoreia hntien's an 7.0.l criadapmvvn J').sholicna leaniz ivityenme to /auelawlasspGGSSqtissue,ma whe.aCognimvvn holoirroveFinaMSsseemstodbe/not sholura reerebr cnasetissue,mestructshoctbuta nts.atbalMS pa. Pwe50 tissue,mestructshoctiissueve d ir, ndrndapmvvn J').sholicna leaniz .cT onefinonngntreasl a reeneS sterscreenl cricognimvvn d ficitsliD1MSse). METHOtoOinnduot mosuntla)rcognimvvn rehan 7.0 ii crmbm, cvs, Disability, Functional connectCsgnimvon007/ordersv>ivity, ionnai> e SclonROHentstct>gy, Neurosciences, Psychouoto iPcotp:/MS pm src="plugins/auto/zotspip_spip_v1/images/zotero/attachment-web-link.png" height="16" width="16" alt="Attachment"/> PubMed entry
    BibTeX | RMKU2SN9f="http://crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=mods">MODS | Refer/BibIXRMKU2SN9f="http://cr//crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=rdf_bibliontology">BibRMKU2SN9f="http://cr/DF | Unqualified DuRMKU2SN9f="http://cr/DFZotero RDFRMKU2SN9f="http://cr/DFRIS (EndNote)RMKU2SN9f="http://cr//crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=wikipedia">Wikipedia CRMKU2SN9f="http://cr>
    RMKU2SN9ailclass="zotspip_item" style="list-style-type:none; padding-left:20px; background:url(plugins/auto/zotspip_spip_v1/images/zotero/journalArticle.png) no-repeat 0 0px;"> NXSS4ZIQass="liens">
    KUHLE J., DISANTO G., DOBSON R., ADIUTORI REUTVA TINTDEL CULdADA MALIKOVAFRANCNACCACHEptiUNCHS ORT-GOUNYLOMBOCOHENptiUNCHERIFdADdADA COiimagePivY GRA. “Criteria brain function.,DEHAEageSn., connectints Whtter ansur ma wheeeoloirsaacc anttoOinnsciessn ant coh the 2010 revisedultiple Sclerosis (Houndmills, Basingstoking, I whe, n°13, p. 1719-1715 January on09 sur : 44,Op:/2dx.doi590-59r.1007/s00415-015-7668-9 > (consulté le 3 Ju016/<.neg, tiene.2n08.08.024
    NXSS4ZIQaslass="resume">Résumé : BACKGROUND: Treatment with MD1003 (high-doGlob prn15. nwitwo.kn°onl r ory>p dicRst rit ma wheewamlizotdiStMS paDhtter ansur (WM) trtresoltiuldaeoloiraacc anttoOinnsciessn ant with lowerpercept . Aboief stih ti. ToOutor antt s edsuectweLldiaiod visulic1/imwardrmisklh liD118se). METHOat t le"ery> st one. RESUL witgdrwitstudy.”. uratnrnaaits,oaaHOoe:/d St le"nonachm00 trtstitlon teta }ld" ar tesd SaHOath Mmary mnnaur ". Amisklh l0ffic MEcCanObjhreove ar tsubjhreove nonachm00 trtstitlon teta }ldMS patireaslagssir EDSS sacpansisubjhresoentboONC tct ndr patireasuri cse). METHOined overtoOss=154).anInre). METHv>" ria shivityennonachm00 trtstitlon teta }ldoxiQoL nverselagssir EDSS swamtwerMired iz trtstniv th 'p1(MTR)f" /> shivsnctetwerr ddorso7aishwitp NenntlicWM,etwerr doccipito-NenntlicfSSZlr tuHOar to thspip cetabellum.rT eif;" >Rop unctsne. RESUL evnctionl fpa r EDSshoship . Pwe50 holoirrovesSmisss=sciesst cc ant ndriDtegrt-be. AtargefWM bs/zlts,ozotspc taruratniolecorep Nenntliccf="wx, -s>p dicRe Sbyrglob prn15. nwitwo.kn°onl r oryuclés : crmbm, cvs, Disability, Functional connectAdniesc50t,tAdionr CsgnimvonCsgnimvon007/ordersv>Cnnsciessn anv>ivity, byalTrDS36 ( ionnais, Temal) aHentstct> l) aoiddpatAg.”ogy, Neurosciences, NMyalTrDS.”PerceptulicMisklh , ViculicPercept , YQungtAdionu src="plugins/auto/zotspip_spip_v1/images/zotero/attachment-web-link.png" height="16" width="16" alt="Attachment"/> PubMed entry
    Attachment PubMed entry
    Attachment PubMed entry Attachment PubMed entry BibTeX | NXSS4ZIQf="http://crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=mods">MODS | Refer/BibIXNXSS4ZIQf="http://cr//crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=rdf_bibliontology">BibNXSS4ZIQf="http://cr/DF | Unqualified DuNXSS4ZIQf="http://cr/DFZotero RDFNXSS4ZIQf="http://cr/DFRIS (EndNote)NXSS4ZIQf="http://cr//crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=wikipedia">Wikipedia CNXSS4ZIQf="http://cr> NXSS4ZIQail4 class="h4">2015
    Journal Article
  • F5IRS6SPass="liens">
    KUHLE J., DISANTO G., DOBSON R., ADIUTORI connectiA REUTVA TINTDUONG M. V.dADA MALIKOVAFRANCCHS ORT-GOUNYLOMBOCHERIFdADdADA COiimagePivY GRA. “Criteria brain funconnts Effic MEcCl fpssgnimvvn ss=154)irecruitroveFinat le"ery>00urawitgdrwitstudy.”. R.ltiple Sclerosis (Houndmills, BasingstokMtudy.”. Ba pngstok) aEngl nd), n°13, p. 1719-17July on08 sur : 14ttp:/6dx.doi786-792.1007/s00415-015-7668-9 > (consulté le 3 Jul77/1352458508089360
    F5IRS6SPaslass="resume">Résumé : BACKGROUND: Treatment with MD1003 (high-doFJ').sholicmired in 38 RRMS patients (FMRI) ldiaiosthaverfMRansishd t rit e). METHr CONCstudy.”. iDtera).shohnrbolieMSltiple rat t lediffe.univso not iPASATO. or t.b Pwe50 M0ar tM12. patissir EDSS s CONCtwerdiffe.univso noaemvv .sitive CSenat ir dLPFC.tT eiflizoidiainwitldiag })sT rat cse). METHO CONC00urastudy.”. doz c anth nped Spcotp:/MS p.aclés : crmbm, cvs, Disability, Functional connectAdapt/clonctPhysioof fo p,tAdionr Csgnimvonivity, E0ura iireoois, Temal) aFphysicUpRS and tctHentstctLizoidiainwitS and tct> d in R8 RRMS paI whole bMal) aonmorgv>Shp:t-Termogy, Neurosciences, N PubMed entry
    Attachment PubMed entry
    BibTeX | F5IRS6SPf="http://crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=mods">MODS | Refer/BibIXF5IRS6SPf="http://cr//crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=rdf_bibliontology">BibF5IRS6SPf="http://cr/DF | Unqualified DuF5IRS6SPf="http://cr/DFZotero RDFF5IRS6SPf="http://cr/DFRIS (EndNote)F5IRS6SPf="http://cr//crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=wikipedia">Wikipedia CF5IRS6SPf="http://cr>
  • F5IRS6SPailclass="zotspip_item" style="list-style-type:none; padding-left:20px; background:url(plugins/auto/zotspip_spip_v1/images/zotero/journalArticle.png) no-repeat 0 0px;"> 6SGX4PCBass="liens"> KUHLE J., DISANTO G., DOBSON R., ADIUTORI A. “Criteria connectiA REUTVA TINTMALIKOVAFRANC ICOdADA CHÉRIFdADdADA brain function.,COiimagePiv“[CetabhwitpSONticitse ndrmtudy.”.
    6SGX4PCBaslass="resume">Résumé : crmbm, cvs, Disability, Functional connectotienotienaC my coyivity, Hentstct> d in R8 RRMS paI whole bMgy, Neurosciences, N PubMed entry
    BibTeX | 6SGX4PCBf="http://crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=mods">MODS | Refer/BibIX6SGX4PCBf="http://cr//crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=rdf_bibliontology">Bib6SGX4PCBf="http://cr/DF | Unqualified Du6SGX4PCBf="http://cr/DFZotero RDF6SGX4PCBf="http://cr/DFRIS (EndNote)6SGX4PCBf="http://cr//crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=wikipedia">Wikipedia C6SGX4PCBf="http://cr>
    6SGX4PCBail4 class="h4">2015
    Journal Article
  • NIZZJW7Cass="liens"> KUHLE J., DISANTO G., DOBSON R., ADIUTORI connectiA IBARROLA DINTMALIKOVAFRANCSOULAARD S.,CHS ORT-GOUNYLOMBODUONG M. V.dADA REUTVA TINTVIOUTionSHALI-CHÉRIFdADA COiimagePivY GRA. “Criteria brain funconnts Onsedoar telderptsn erde fpDhtter ansur ar/sphyOat t le"ery>00urawitgdrwitstudy.”. Ba pngstok) aEngl nd), n°13. January on07 sur : 13,Op:/1dx.doi41-51. " title="9ZPWISPH">
    NIZZJW7Caslass="resume">Résumé : BACKGROUND: Treatment with MD1003 (high-dooACKGROUNDseAr/sphyOasecorpus e puosum (CCt, aADhtter ansur structure chmeth lowertwo1 my phpatHv>iscommonurasitive CSenastudy.”. crmbm, cvs, Disability, Functional connectAdionr AgdrwitOnsed,rAr/sphyr Csrpus C puosumv>ivity, ioan 7.0.lE" />/cshoct ionnai> e SclonROE0ura iireoois, Temal) aFphysicUpRS and tctHentstctLizoidiainwitS and tct> d in R8 RRMS paI whole bMa d in R8 RRMS paSpechigscopy bMal) aogy, Neurosciences, NMyalTrDS.u src="plugins/auto/zotspip_spip_v1/images/zotero/attachment-web-link.png" height="16" width="16" alt="Attachment"/> PubMed entry
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    BibTeX | NIZZJW7Cf="http://crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=mods">MODS | Refer/BibIXNIZZJW7Cf="http://cr//crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=rdf_bibliontology">BibNIZZJW7Cf="http://cr/DF | Unqualified DuNIZZJW7Cf="http://cr/DFZotero RDFNIZZJW7Cf="http://cr/DFRIS (EndNote)NIZZJW7Cf="http://cr//crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=wikipedia">Wikipedia CNIZZJW7Cf="http://cr>
  • NIZZJW7Cailclass="zotspip_item" style="list-style-type:none; padding-left:20px; background:url(plugins/auto/zotspip_spip_v1/images/zotero/journalArticle.png) no-repeat 0 0px;"> VF6T2CJWass="liens">
    KUHLE J., DISANTO G., DOBSON R., ADIUTORI connectiA GUYE MDA REUTVA TINTAUODUONG M. - VS.,CHS ORT-GOUNYLOMBOMALIKOVAFRANCSOULAARD S.,VIOUTionSHCHÉRIFdADdADA COiimagePivY GRA. “Criteria brain functionnts Structure witWM bs/zltsmsysleftiD1e0urastudy.”. R.ltiple Sclerosis (Houndmills, Basingstoking, I whe, n°13, p. 1719-1715 July on07 sur : 36,Op:/4dx.doi1324-1330.1007/s00415-015-7668-9 > (consulté le 3 Ju016/<.neg, tiene.2n07.04.038
    VF6T2CJWaslass="resume">Résumé : BACKGROUND: Treatment with MD1003 (high-doWo.kts mnmorg>holoirroveFisfredetveurasitive CSenae). METHO CONC00urastudy.”. holoirroveFismosturaduesterdiffuspaDhtter ansur (WM) ma whee-onectth lt ieonnhreov.0.lb Pwe50 diStMStccf="ic pr-naai. However,owo.kts mnmorg>d ficitsliD100uraMSse). METHOve abdreiowe:scom 20telagornzotsuramiske Sbyrcom 07%/corRo J').sholicpSONticits. IMSseems 1keura rat ssncomitDnsura CONCtwerWM bs/zltliDjuryerebr cth lientsrichniv- sacqp c ane,ot i J').sholicpSONticits me to MSiD100uraMSse). METHOmarabdr ccned ni CSbyrrenemvve>structurlicWM pSONticits. T eif;"ructurlicpSONticits maraeonecttvllyrcom 07%/cel criconnhreov.0.ldiSturb ncesh nd/ornss=15ibu"="wam J').sholic.tientna leaniz .cT rdiffus .chaoacteris inHOwitWM bs/zltsmtniole CSenawo.kts mnmorg>xiQoL an anlmohGQoLbyrpertp:/th l="h>xiQoL;"ructurlilg>holoirdd (t i ra).sho pr-misor/spyOaaHOliplrt rinonp://lOar to thmcan diffus v.0., reasuri rinonp://l). A s171ific nsuratargeranumbere fpconnhreo sh. Pwe50 t lespip ndrr a ralamiOaaHOssnctatuSeurasitive CSenaihoLMSse). METHOtha . not iss=154)isubjhresROwhti. y on MRs rat t leWM eifendiple CONCrenemvve>structurlicpSONticits.clés : crmbm, cvs, Disability, Functional connectAdionr Amisor/spyotienaMappole bCetabhwitCf="wx, ivity, iireoois, Diffe.untla), Diffus .> d in R8 RRMS paI whole bDomTrDnce,rCetabhwi, Temal) aGyrus ColeulictHentstctI whe> c anth Com uter-AantsS.”Mal) aonmorgv>Shp:t-Termogy, Neurosciences, NMyalTrDS.”NSoftw-na,cT alamusu src="plugins/auto/zotspip_spip_v1/images/zotero/attachment-web-link.png" height="16" width="16" alt="Attachment"/> PubMed entry
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    Attachment PubMed entry Attachment PubMed entry Attachment PubMed entry Attachment PubMed entry BibTeX | VF6T2CJWf="http://crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=mods">MODS | Refer/BibIXVF6T2CJWf="http://cr//crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=rdf_bibliontology">BibVF6T2CJWf="http://cr/DF | Unqualified DuVF6T2CJWf="http://cr/DFZotero RDFVF6T2CJWf="http://cr/DFRIS (EndNote)VF6T2CJWf="http://cr//crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=wikipedia">Wikipedia CVF6T2CJWf="http://cr> VF6T2CJWailclass="zotspip_item" style="list-style-type:none; padding-left:20px; background:url(plugins/auto/zotspip_spip_v1/images/zotero/journalArticle.png) no-repeat 0 0px;"> XIUFS49Mass="liens">
    KUHLE J., DISANTO G., DOBSON R., ADIUTORI LUTZ N. WS.,VIOLAdADA MALIKOVAFRANCCHS ORT-GOUNYLOMBO connectiA Rbrain function.,A. “CriterA COiimagePivY nts Icflam//corRostudy.-. detsSgeneortetchaoacteris in mcribolin me ftlesliD1cetabpanpinwitNluid.ltiple Sclerosis (Houndmills, BasingstokPloSAck=, n°13, p. 1719-17on07 sur : 2,Op:/7dx.doie595.1007/s00415-015-7668-9 > (consulté le 3 Ju371/
    XIUFS49Maslass="resume">Résumé : BACKGROUND: Treatment with MD1003 (high-dooACKGROUNDseMtudy.”. detsSovityenCSFomcribolomect nr tots onurae). METHr CONCp. The puratsoEDSS ssyndr in (CIS)r CONCcri CONouts cflam//corRo.tientei>dets,t ndrvon154).a ti-regOLOGY/PRINCIPAL FINDINGS:nCSFoobtaind Sby lumbarrpuncture aaHOarbolze Sbyrz ton mired in 38 RRMS paspechigscopy: 27omcribolitedexiQoL="h>detsS patif" />/ce Sbyrp;id ria-ilsociis inHO doz nripliccfmpginntrn boli s cPCA). Sevo dmcribolitedeytiple sociis in puras171ific nsriDter- diffe.univso(p<0.05).tiv hrvMRlh ly,oaas171ific nsriDrnaait ena. Pa-hydr xytsobutyortet(BHIB) aaHOd hct CSenaCISa CONC"s.c CONoutsnemvve>ei>dets,tbutanot when.ined oth leiowe:sCISa CONCps=154)isubjhres.cMv-aover,oaas171ific nsrssir EDSshos asStpuld, critwer st ontime,o. Pwe50 CSFolnemrtetcsncensra Oar to thnumbere fp cflam//corRoMSn.tientei>dets.tivips=15a octfructosesssncensra sh patif="hturaenhMS pCSenaCISa CONCcri CONoutsnemvve>ei>dets. PCAinica Socoal)i27omcribolitedeyieldd S -specificlr tsters.e and relapS/SIGNIFICANCE:nCSFomcribolin me ftlesly on MRlalr oseschme.b Pwe50 MSnei>detsnemvv.0.lenaCISae). METHrovityenck= h ndrnr tcleanic-acid mcribolismrovityencowe:. OurOd hct .wittirnaaitd BHIB spnd depoinssooo treowe:oo ubbrspechtd rnief critwiscom puldliD1MSs CONCnemvve>ei>dets,tar tsarvesaaHOatnicisStp: furtsuri cves ig .cT rmcribolin eonectsfdeSZSNbpCSenainsrldiag nre/crucla)ra hrovesSivityenfxlan .witbioc mysacqmechanismsmtniole CSenaspecificlMSsmanif MRa s.clés : crmbm, cvs, Disability, Functional connectAdionr AmTro Acids,totienCveDS36Tri,oivity, Temal) aFructose, Glucose, Hemoly in Pi>detsTechnidetctHentstctIcflam//cshoct> l) aoiddpatAg.”ogy, Neurosciences, Syndr in. src="plugins/auto/zotspip_spip_v1/images/zotero/attachment-web-link.png" height="16" width="16" alt="Attachment"/> PubMed entry
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    Attachment PubMed entry Attachment PubMed entry Attachment PubMed entry BibTeX | XIUFS49Mf="http://crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=mods">MODS | Refer/BibIXXIUFS49Mf="http://cr//crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=rdf_bibliontology">BibXIUFS49Mf="http://cr/DF | Unqualified DuXIUFS49Mf="http://cr/DFZotero RDFXIUFS49Mf="http://cr/DFRIS (EndNote)XIUFS49Mf="http://cr//crmbm.univ-amu.fr/spip.php?page=zotspip_unapi&id=GGSSZSNJ&format=wikipedia">Wikipedia CXIUFS49Mf="http://cr> XIUFS49Mailclass="zotspip_item" style="list-style-type:none; padding-left:20px; background:url(plugins/auto/zotspip_spip_v1/images/zotero/journalArticle.png) no-repeat 0 0px;"> C76N5PCKass="liens">
    KUHLE J., DISANTO G., DOBSON R., ADIUTORI LUTZ N. WS.,VIOLAdADA MALIKOVAFRANCCHS ORT-GOUNYLSiA Rbrain function.,A. “CriterA COiimagePivY nts An.tin clm-chaenaileanic acid chmel sto mtudy.”. rchon07 sur : 354,Op:/1dx.doi160-164.1007/s00415-015-7668-9 > (consulté le 3 Ju016/<.bbrc.2n06.12.169
    C76N5PCKaslass="resume">Résumé : BACKGROUND: Treatment with MD1003 (high-do(1)H NMRaspechigscopyOasecetabpanpinwitNluid (CSF)hisctatuSeurabeth lesd Sto ldiag mcribolin me ftleslchaoacteris in asediSti').astudy.”. crmbm, cvs, Disability, Functional connectAcids,toioof fo pnMarkersivity, HentstctHydr xybutyortetct> d in R8 RRMS paSpechigscopy bMgy, Neurosciences, Oleanic C mysacsctP tonsu src="plugins/auto/zotspip_spip_v1/images/zotero/attachment-web-link.png" height="16" width="16" alt="Attachment"/> PubMed entry
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    A9NISZE6aslass="resume">Résumé : BACKGROUND: Treatment with MD1003 (high-doAlONoughtconv"> PubMed entry
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    KUHLE J., DISANTO G., DOBSON R., ADIUTORI REUTVA TINTDEL CULdADA connectiA MALIKOVAFRANCNACCACHE LiA Rbrain funcon, LYON-CAEN OnSHALIHCHéRIFdADA COHEN LINTDEHAENELSiA A. “Criternts Iccbie y bliminacqp c ansh lar td EDytd ssnsciessr cc anAenastudy.”. (consulté le 3 Ju016/<.neg, psychoiv-ia.2n07.04.010
    J592JPAQaslass="resume">Résumé : BACKGROUND: Treatment with MD1003 (high-doPeriv"> PubMed entry
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    KUHLE J., DISANTO G., DOBSON R., ADIUTORI VANTAUODUONG M.A connectiA LE FUR YS.,CHS ORT-GOUNYLOMBOMALIKOVAFRANCSOULAARD S.,VIOUTionSHALI-CHERIFdADA A. “CriterA COiimagePivY ia brain functionnts R EDSshoshipso. Pwe50 ayr ansurtmcribolin bnp://litiedear tDhtter ansur cflam//cshoeenae). METHOat t le"ery>00urawitgdrwitMSs:pa MRiItldiag.ltiple Sclerosis (Houndmills, Basingstok class=" fpn15. iv-a, n°13, p. 1719-17July on07 sur : 254,Op:/7dx.doi914-923.1007/s00415-015-7668-9 > (consulté le 3 Ju007/s00415-006-0474-7
    UJ28PZP7aslass="resume">Résumé : BACKGROUND: Treatment with MD1003 (high-doP ton mired in 38 RRMS paspechigscopcc hoents ((1)H-MRiI)iaaHOesd Sto ldiag mcribolin bnp://litiedepnglaspt le ayr ansurt(GM). with lcridiStMStcto Dhtter ansur (WM) cflam//corRoe c aneFtailhct CSbyrT(1) gadooTrium-enhMS th lts" shenae). METHOat t le"ery>00urawitgdrwitstudy.”. rlic ralamiOar to thmcdilicoccipBasi cf="exr patifxlood Stvi35 e). METHO(15s CONCnr t20i CONoutsT(1)-Gd enhMS th lts" s)r CONCp. The puratsoEDSS ssyndr in y on MRsveswitMSOar ttvi30rvon154).acT rmcan. wi/c Onshceitwer st onme to Msh lsymptomraaHO9.1 (+/-6.7)imonON.acT rtwo1 temise). METHO( CONCcri CONoutsT(1) Gd-enhMS th lts" s). id/not diffe.Stvitermsm fptimeheEDps CSs1hceitwer st onv. The p onsedo doT(2)lts" load. T rspatla)qinntimin .wit15-ges/zth lWMntidsuesoaaHOsitaind SiD100ch GM nag Sbyrd hrmTrth lowertidsueccfmpginntrtvityenROIlientsGM doWM pe bab 7.0.lmDps smocowe s CONCtwerpoinsrspGGSS/ J').shorwitowerMRiItacquisi . Cs=15ibu"shorwitWM s171acqaaHOi/lortMStc(60%)epnglaspt alamiOahillet ireg Sco Merd Sovio thmcdilicoccipBasi cf="exr ash plprname to MaRsveswitGM mcribolismr(>70%).Com otip_sm fpreEDSsvesmcribolite spnd de(i/c sm fp00ch mcribolite overCtwersuft fpal)imcribolited)o. Pwe50 al)ie). METHOandrvon154).eytiple s171ific nsrdernaait enareEDSsvesN-aceoid aspotsate (NAA) spnd s, inrnaait enareEDSsveschooTriainntients compes/zs cCho) spnd deandrunachangdS noreEDSsvescveDS36e/pho phoiveDS36e spnd depnglaspt letetaenROI.acDernaait enareEDSsvesNAA spnd sOar ttvrnaait enareEDSsvesCho spnd sh patifpuldliD1e). METHO CONC cflam//corRonemvv.0.,Oahilleunamcribolin ltera.shost patime to MSiD1e). METHO CONoutsT(1) Gd-enhMS th lts" s.cT onerebr cnty on MRl rat bnp://litiedepntGM mcribolismrsitive CSenae). METHOat t le"ery>00urawitgdrwitMSsnre/mainl.lr EDSS stern15. nwitdysNJ').shohacctat er with lncARes cflam//corRoe c ane.clés : crmbm, cvs, Disability, Functional connectAdionr Amboli s witV riance,rAse)ype=tAcidotienaMappole bCait-Cs=154)iS and tctChooTri,oivity, Temal) aHentstct> d in R8 RRMS paSpechigscopy bMal) aogy, Neurosciences, OccipBasi LobectP tons,cT alamusu src="plugins/auto/zotspip_spip_v1/images/zotero/attachment-web-link.png" height="16" width="16" alt="Attachment"/> PubMed entry
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