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Développement de méthodes

responsable : Frank Kober

Organizational chart

The team is coordinated by Frank Kober (cardiac MRI, MRS, ASL on heart and brain). Permanent members are Yann Le Fur (MRS and post-processing), Guilaume Duhamel (ASL on brain, spine and kidney, MT), Olivier Girard (ASL on spine, SWI, UTE, MT) and Jean-Philippe Ranjéva (Sodium MRI, brain fMRI). We currently host 2 Ph.D. Students (Thomas Troalen, Angèle Lecoq) and 3 Master’s students (Julien Pugnaire, Christian Kenmoe, Valentin Prevost).

Mission statement

CRMBM’s MR methods group focuses on the development of tailored MRI and MRS techniques for small animal and human MR studies. Current main topics
  • Arterial Spin Labeling perfusion MRI (ASL) on brain, spine and heart
  • Quantitative MR spectroscopy and post-processing for imaging and spectroscopy on brain, spine, skeletal muscle and heart
  • Magnetization Transfer (MT) MRI
  • Other functional and parametric imaging techniques

We aim at developing original dedicated state-of-the art MRI methods. The developed techniques integrate with CRMBM’s application research topics and aim at assessing organ microcirculation and metabolism as key parameters for the diagnosis of many pathologies and non-invasive treatment monitoring. The methods group also provides a scientific interface to MR manufacturers.

Main topics

Sequence Development

CRMBM’s MR method research has a strong focus on Arterial Spin Labeling Perfusion MRI, Diffusion Tensor MRI, Magnetization transfer imaging, BOLD MRI, and quantitative MR Spectroscopy. Original MR sequences are established and used within multimodal MRI/MRS protocols.

The MR methods group develops sequences under both Siemens IDEA and Bruker Paravision development environments. Dedicated post-processing is mostly developed under Interactive Data Language and Matlab, but also using BrainVisa and FSL tools.

Steady-pulsed cine-ASL as a new arterial spin labeling technique for non-invasive highly time-resolved assessment of myocardial perfusion in vivo. T. Troalen, T. Capron, F. Kober.

Pulsed ASL (FAIR-QUIPSSII) and pseudocontinuous (ubpCASL) sequences in comparison for mouse brain perfusion MRI at 11.75T. G. Duhamel Renal perfusion at 11.75T using pseudocontinuous ASL. V. Prevost, G. Duhamel. T2-weighted anatomical image of a mouse brain and a corresponding absolute CBF map obtained with a Look-Locker Arterial Spin Labeling (ASL) gradient-echo sequence at 4.7T. MF. Penet, A. Viola, F. Kober.
Dedicated Cerebral Spinal Fluid suppression module for ASL of human spinal cord (left) and overlay images (right) of control images and color-coded FAIR Tag/Control signal difference maps at different TI values evidencing measurable spinal cord blood flow in humans. O. Girard, G. Duhamel.

Post-processing development

Human cardiac phosphorus MRS with optimized weighted CSI, realtime voxel-shift FFT and metabolite map calculation. The developed MRS post-processing allows for grid-free voxel positioning, visualization of true voxel sizes and profiles, and it interfaces with AMARES time-domain spectral fitting. Y. Le Fur. F. Kober.