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DONADIEU Maxime

Master of Science, PhD Student

maxime.donadieu@etu.univ-amu.fr
tel : +33 4 91 38 62 62
Key Words
- MR Spectroscopy Imaging
- Multiple Sclerosis
- Molecular Neurosciences
- Axonal Mechanisms

Current Research Interest and projects

PhD Project (2015-2018): MR Spectroscopy Imaging at high (3 Tesla) and ultra high (7 Tesla) field : Methodological development and clinical application on neurodegenerative diseases (PhD supervisor : Jean-Philippe Ranjeva )

- Development of MR spectroscopy Imaging (MRSI) techniques at high and ultra high field (3 and 7 Tesla) in order to quantify neuronal and glial metabolism in cortical and subcortical areas like pre-frontal cortex, thalamus (Fig.1) or hippocampus of healthy subjects (in collaboration with doctor Yann Le Fur)

- Study the topography of metabolic disorders of one of the most important neurodegenerative disease affecting the young adult : the Multiple Sclerosis (MS) using MRSI techniques previously developed in the CRMBM or resulting from collaboration with other group (Fig.2) (University of Florida, Miami with Andrew Maudsley, see Lecocq et al. 2015, jMRI / University of Minnesota, Minneapolis).

- Establish a longitudinal follow up of our MS patients in order to study temporal evolution of metabolic disorders and their links with the evolution of clinical scores or others pathological processes like atrophy or sodium accumulation.

Picture gallery:

  • Fig. 1 : Example of two spectra obtained for two intra-thalamic voxels (respectively : the right pulvinar and the left anterior) at 7 Tesla [high resolution 2D-semi-LASER sequence (C2P from CMRR Minneapolis)] . See Donadieu et al. 2016, MAGMA .


  • Fig. 2 : Whole-brain topography of NAA decrease (blue) in Relapsing-Remitting MS patients compared to healthy controls (overlaid with atrophy mask (green) and WM lesions mask (purple)). See Donadieu et al. 2016, jMRI [in collaboration with the University of Florida] .

Works presented in National and International congress:

-  French Society for Magnetic Resonance in Biology and Medicine (SFRMBM) Grenoble 2015 (National congress):

Cartographies statistiques d’imagerie spectroscopique 3D multi-métabolites de l’ensemble du cerveau appliquées à la sclérose en plaques (Oral communication)

-  International Society for Magnetic Resonance in Medicine (ISMRM) Toronto 2015 (International congress):

Whole brain multi-metabolite statistical mapping analysis to characterize metabolic disorders in multiple sclerosis using combination of two tilted 3D-EPSI acquisitions (E-poster communication)

- European Committee for Treatment and Research In Multiple Sclerosis (ECTRIMS) Barcelona 2015 (International congress):

Topography of metabolic abnormalities over the entire brain using voxel-wise statistical mapping of fast 3D-MRSI Proof of concept on Multiple Sclerosis (Poster communication)

-  Workshop ARSEP Paris 2016 (International congress):

Metabolic voxel-based analysis of the complete human brain using fast 3D-MRSI: Proof of concept on Multiple Sclerosis (Oral communication)

-  International Society for Magnetic Resonance in Medicine (ISMRM) Singapour 2016 (International congress):

Evidencing different neurochemical profiles between thalamic nuclei using high resolution 2D-PRESS semi-LASER 1H-MRSI at 7T (Oral communication)

Awards:

- Cartographies statistiques d’imagerie spectroscopique 3D multi-métabolites de l’ensemble du cerveau appliquées à la sclérose en plaques.
Maxime Donadieu, Yann Le Fur, Angèle Lecocq, Andrew A Maudsley, Elisabeth Soulier, Soraya Gherib, Fanelly Pariollaud, Marie-Pierre Ranjeva, Sylviane Confort-Gouny, Wafaa Zaaraoui, Maxime Guye, Jean Pelletier, Bertrand Audoin and Jean-Philippe Ranjeva
Best scientific oral presentation (SFRMBM Grenoble 2015, National congress)

- Whole brain multi-metabolite statistical mapping analysis to characterize metabolic disorders in multiple sclerosis using combination of two tilted 3D-EPSI acquisitions.
Maxime Donadieu, Yann Le Fur, Angèle Lecocq, Andrew A Maudsley, Elisabeth Soulier, Soraya Gherib, Fanelly Pariollaud, Marie-Pierre Ranjeva, Sylviane Confort-Gouny, Wafaa Zaaraoui, Maxime Guye, Jean Pelletier, Bertrand Audoin and Jean-Philippe Ranjeva
Third price of the White Matter Study Group (ISMRM Toronto 2015, International congress)

- Topography of metabolic abnormalities over the entire brain using voxel-wise statistical mapping of fast 3D-MRSI Proof of concept on Multiple Sclerosis.
Maxime Donadieu, Yann Le Fur, Angèle Lecocq, Andrew A Maudsley, Elisabeth Soulier, Soraya Gherib, Fanelly Pariollaud, Marie-Pierre Ranjeva, Sylviane Confort-Gouny, Wafaa Zaaraoui, Maxime Guye, Jean Pelletier, Bertrand Audoin and Jean-Philippe Ranjeva
ECTRIMS merit grant (ECTRIMS Barcelona 2015, International congress)

Grants:

- PhD Grant (CIFRE) supported by Siemens France and the French ‘Association Nationale Recherche et Technologie’ (ANRT).

Publications

2016

Journal Article

  • DONADIEU M., LE FUR Y., CONFORT-GOUNY S., LE TROTER A., GUYE M., RANJEVA J. - P. “Evidencing different neurochemical profiles between thalamic nuclei using high resolution 2D-PRESS semi-LASER (1)H-MRSI at 7 T.”. Magma (New York, N.Y.) [En ligne]. 2016. Disponible sur : < http://dx.doi.org/10.1007/s10334-016-0556-1 > (consulté le no date)
    Résumé : OBJECTIVE: To demonstrate that high resolution (1)H semi-LASER MRSI acquired at 7 T permits discrimination of metabolic patterns of different thalamic nuclei. MATERIALS AND METHODS: Thirteen right-handed healthy volunteers were explored at 7 T using a high-resolution 2D-semi-LASER (1)H-MRSI sequence to determine the relative levels of N-Acetyl Aspartate (NAA), choline (Cho) and creatine-phosphocreatine (Cr) in eight VOIs (volume <0.3 ml) centered on four different thalamic nuclei located on the Oxford thalamic connectivity atlas. Post-processing was done using the CSIAPO software. Chemical shift displacement of metabolites was evaluated on a phantom and correction factors were applied to in vivo data. RESULTS: The global assessment (ANOVA p < 0.05) of the neurochemical profiles (NAA, Cho and Cr levels) with thalamic nuclei and hemispheres as factors showed a significant global effect (F = 11.98, p < 0.0001), with significant effect of nucleus type (p < 0.0001) and hemisphere (p < 0.0001). Post hoc analyses showed differences in neurochemical profiles between the left and the right hemisphere (p < 0.05), and differences in neurochemical profiles between nuclei within each hemisphere (p < 0.05). CONCLUSION: For the first time, using high resolution 2D-PRESS semi-LASER (1)H-MRSI acquired at 7 T, we demonstrated that the neurochemical profiles were different between thalamic nuclei, and that these profiles were dependent on the brain hemisphere.
    Mots-clés : 1H-MRSI, Connectivity atlas, crmbm, Neurochemical profiles, Thalamic nuclei, Ultra high field.

  • DONADIEU M., LE FUR Y., LECOCQ A., MAUDSLEY A. A., GHERIB S., SOULIER E., CONFORT-GOUNY S., PARIOLLAUD F., RANJEVA M. - P., PELLETIER J., GUYE M., ZAARAOUI W., AUDOIN B., RANJEVA J. - P. “Metabolic voxel-based analysis of the complete human brain using fast 3D-MRSI: Proof of concept in multiple sclerosis.”. Journal of magnetic resonance imaging: JMRI [En ligne]. 2016. Vol. 44, n°2, p. 411-419. Disponible sur : < http://dx.doi.org/10.1002/jmri.25139 > (consulté le no date)
    Résumé : PURPOSE: To detect local metabolic abnormalities over the complete human brain in multiple sclerosis (MS) patients, we used optimized fast volumic echo planar spectroscopic imaging (3D-EPSI). MATERIALS AND METHODS: Weighted mean combination of two 3D-EPSI covering the whole brain acquired at 3T in AC-PC and AC-PC+15° axial planes was performed to obtain high-quality metabolite maps for five metabolites: N-acetyl aspartate (NAA), glutamate+glutamine (Glx), choline (Cho), myo-inositol (m-Ins), and creatine+phosphocreatine (tCr). After spatial normalization, maps from 19 patients suffering from relapsing-remitting MS were compared to 19 matched controls using statistical mapping analyses to determine the topography of metabolic abnormalities. Probabilistic white matter (WM) T2 lesion maps and gray matter (GM) atrophy maps were also generated. RESULTS: Two-group analysis of variance (ANOVA) (SPM8, P < 0.005, false discovery rate [FDR]-corrected P < 0.05 at the cluster level with age and sex as confounding covariates) comparing patients and controls matched for age and sex showed clusters of abnormal metabolite levels with 1) decreased NAA (around -15%) and Glx (around 20%) predominantly in GM within prefrontal cortices, motor cortices, bilateral thalami, and mesial temporal cortices in line with neuronal/neuro-astrocytic dysfunction; 2) increased m-Ins (around + 20%) inside WM T2 lesions and in the normal-appearing WM of temporal-occipital lobes, suggesting glial activation. CONCLUSION: We demonstrate the ability to noninvasively map over the complete brain-from vertex to cerebellum-with a validated sequence, the metabolic abnormalities associated with MS, for characterizing the topography of pathological processes affecting widespread areas of WM and GM and its functional impact. J. Magn. Reson. Imaging 2016;44:411-419.
    Mots-clés : crmbm, Inflammation, Multiple Sclerosis, neurodegeneration, proton magnetic resonance spectroscopic imaging, statistical mapping analysis, whole brain.

2015

Journal Article


  • COULL J. T., CHARRAS P., DONADIEU M., DROIT-VOLET S., VIDAL F. “SMA Selectively Codes the Active Accumulation of Temporal, Not Spatial, Magnitude.”. Journal of Cognitive Neuroscience [En ligne]. 2015. Vol. 27, n°11, p. 2281-2298. Disponible sur : < http://dx.doi.org/10.1162/jocn_a_00854 >

  • LECOCQ A., LE FUR Y., MAUDSLEY A. A., LE TROTER A., SHERIFF S., SABATI M., DONADIEU M., CONFORT-GOUNY S., COZZONE P. J., GUYE M., RANJEVA J. - P. “Whole-brain quantitative mapping of metabolites using short echo three-dimensional proton MRSI.”. Journal of magnetic resonance imaging: JMRI [En ligne]. 2015. Vol. 42, n°2, p. 280-289. Disponible sur : < http://dx.doi.org/10.1002/jmri.24809 > (consulté le no date)
    Résumé : BACKGROUND: To improve the extent over which whole brain quantitative three-dimensional (3D) magnetic resonance spectroscopic imaging (MRSI) maps can be obtained and be used to explore brain metabolism in a population of healthy volunteers. METHODS: Two short echo time (20 ms) acquisitions of 3D echo planar spectroscopic imaging at two orientations, one in the anterior commissure-posterior commissure (AC-PC) plane and the second tilted in the AC-PC +15° plane were obtained at 3 Tesla in a group of 10 healthy volunteers. B1 (+) , B1 (-) , and B0 correction procedures and normalization of metabolite signals with quantitative water proton density measurements were performed. A combination of the two spatially normalized 3D-MRSI, using a weighted mean based on the pixel wise standard deviation metabolic maps of each orientation obtained from the whole group, provided metabolite maps for each subject allowing regional metabolic profiles of all parcels of the automated anatomical labeling (AAL) atlas to be obtained. RESULTS: The combined metabolite maps derived from the two acquisitions reduced the regional intersubject variance. The numbers of AAL regions showing N-acetyl aspartate (NAA) SD/Mean ratios lower than 30% increased from 17 in the AC-PC orientation and 41 in the AC-PC+15° orientation, to a value of 76 regions of 116 for the combined NAA maps. Quantitatively, regional differences in absolute metabolite concentrations (mM) over the whole brain were depicted such as in the GM of frontal lobes (cNAA  = 10.03 + 1.71; cCho  = 1.78 ± 0.55; cCr  = 7.29 ± 1.69; cmIns  = 5.30 ± 2.67) and in cerebellum (cNAA  = 5.28 ± 1.77; cCho  = 1.60 ± 0.41; cCr  = 6.95 ± 2.15; cmIns  = 3.60 ± 0.74). CONCLUSION: A double-angulation acquisition enables improved metabolic characterization over a wide volume of the brain. J. Magn. Reson. Imaging 2015;42:280-289.
    Mots-clés : crmbm.
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