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PhD Student
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Key Words
- cardiac magnetic resonance (imaging and spectroscopy)

Current Research Interest and projects



Journal Article

  • Abdesselam, I, Dutour, A, Kober, F, Ancel, P, Bege, T, Darmon, P, Lesavre, N, Bernard, M & Gaborit, B 2016, “Time Course of Change in Ectopic Fat Stores After Bariatric Surgery”, Journal of the American College of Cardiology, vol. 67, no. 1, p. 117-119.

  • Galant, D, Gaborit, B, Desgrouas, C, Abdesselam, I, Bernard, M, Levy, N, Merono, F, Coirault, C, Roll, P, Lagarde, A, Bonello-Palot, N, Bourgeois, P, Dutour, A & Badens, C 2016, “A Heterozygous ZMPSTE24 Mutation Associated with Severe Metabolic Syndrome, Ectopic Fat Accumulation, and Dilated Cardiomyopathy”, Cells, vol. 5, no. 2.
    Résumé : ZMPSTE24 encodes the only metalloprotease, which transforms prelamin into mature lamin A. Up to now, mutations in ZMPSTE24 have been linked to Restrictive Dermopathy (RD), Progeria or Mandibulo-Acral Dysplasia (MAD). We report here the phenotype of a patient referred for severe metabolic syndrome and cardiomyopathy, carrying a mutation in ZMPSTE24. The patient presented with a partial lipodystrophic syndrome associating hypertriglyceridemia, early onset type 2 diabetes, and android obesity with truncal and abdominal fat accumulation but without subcutaneous lipoatrophy. Other clinical features included acanthosis nigricans, liver steatosis, dilated cardiomyopathy, and high myocardial and hepatic triglycerides content. Mutated fibroblasts from the patient showed increased nuclear shape abnormalities and premature senescence as demonstrated by a decreased Population Doubling Level, an increased beta-galactosidase activity and a decreased BrdU incorporation rate. Reduced prelamin A expression by siRNA targeted toward LMNA transcripts resulted in decreased nuclear anomalies. We show here that a central obesity without subcutaneous lipoatrophy is associated with a laminopathy due to a heterozygous missense mutation in ZMPSTE24. Given the high prevalence of metabolic syndrome and android obesity in the general population, and in the absence of familial study, the causative link between mutation and phenotype cannot be formally established. Nevertheless, altered lamina architecture observed in mutated fibroblasts are responsible for premature cellular senescence and could contribute to the phenotype observed in this patient.
    Mots-clés : cvs, laminopathy, metabolic syndrome, nuclear anomalies, premature senescence, ZMPSTE24.


Journal Article

  • Abdesselam, I, Pepino, P, Troalen, T, Macia, M, Ancel, P, Masi, B, Fourny, N, Gaborit, B, Giannesini, B, Kober, F, Dutour, A & Bernard, M 2015, “Time course of cardiometabolic alterations in a high fat high sucrose diet mice model and improvement after GLP-1 analog treatment using multimodal cardiovascular magnetic resonance”, Journal of Cardiovascular Magnetic Resonance, vol. 17, no. 1, p. 95, viewed 9November,2015, .
    Résumé : Cardiovascular complications of obesity and diabetes are major health problems. Assessing their development, their link with ectopic fat deposition and their flexibility with therapeutic intervention is essential. The aim of this study was to longitudinally investigate cardiac alterations and ectopic fat accumulation associated with diet-induced obesity using multimodal cardiovascular magnetic resonance (CMR) in mice. The second objective was to monitor cardiac response to exendin-4 (GLP-1 receptor agonist).
    Mots-clés : Cardiovascular magnetic resonance, crmbm, cvs, Diabetes, DIO mice model, Longitudinal study, Obesity, Proton-magnetic resonance spectroscopy.

  • Gaborit, B, Abdesselam, I, Kober, F, Jacquier, A, Ronsin, O, Emungania, O, Lesavre, N, Alessi, M-C, Martin, JC, Bernard, M & Dutour, A 2015, “Ectopic fat storage in the pancreas using 1H-MRS: importance of diabetic status and modulation with bariatric surgery-induced weight loss”, International Journal of Obesity (2005), vol. 39, no. 3, p. 480-487.
    Résumé : OBJECTIVES: Recent literature suggests that ectopic fat deposition in the pancreas may contribute to endocrine and exocrine organ dysfunction, such as type 2 diabetes (T2D), pancreatitis or pancreatic cancer. The aim of this study was to determine factors associated with pancreatic triglyceride content (PTGC), and to investigate the impact of bariatric surgery on ectopic fat pads, pancreatic fat (PTGC) and hepatic fat (HTGC). SUBJECTS: In all, 45 subjects (13 lean, 13 obese nondiabetics and 19 T2D, matched for age and gender) underwent 1H-magnetic resonance spectroscopy, computed tomography of the visceral abdominal fat, metabolic and lipidomic analysis, including insulin-resistance homeostasis model assessment (HOMA-IR), insulin-secretion homeostasis model assessment (HOMA-B) and plasma fatty-acid composition. Twenty obese subjects were reassessed 6 months after the bariatric surgery. RESULTS: PTGC was significantly higher in type 2 diabetic subjects (23.8±3.2%) compared with obese (14.0±3.3; P=0.03) and lean subjects (7.5±0.9%; P=0.0002). PTGC remained significantly associated with T2D after adjusting for age and sex (β=0.47; P=0.004) or even after adjusting for waist circumference, triglycerides and HOMA-IR (β=0.32; P=0.04). T2D, C18:1n-9 (oleic acid), uric acid, triglycerides and plasminogen activator inhibitor-1 were the five more important parameters involved in PTGC prediction (explained 80% of PTGC variance). Bariatric surgery induced a huge reduction of both HTGC (-51.2±7.9%) and PTGC (-43.8±7.0%) reaching lean levels, whereas body mass index remained greatly elevated. An improvement of insulin resistance HOMA-IR and no change in HOMA-B were observed after bariatric surgery. The PTGC or HTGC losses were not correlated, suggesting tissue-specific mobilization of these ectopic fat stores. CONCLUSION: Pancreatic fat increased with T2D and drastically decreased after the bariatric surgery. This suggests that decreased PTGC may contribute to improved beta cell function seen after the bariatric surgery. Further, long-term interventional studies are warranted to examine this hypothesis and to determine the degree to which ectopic fat mobilization may mediate the improvement in endocrine and exocrine pancreatic functions.
    Mots-clés : crmbm, cvs.


Conference Paper

  • Gaborit, B, Jacquier, A, Kober, F, Abdesselam, I, Cuisset, T, Boullu-Ciocca, S, Emungania, O, Alessi, MC, Clement, K, Bernard, M & Dutour, A 2012, “Effect of bariatric surgery on cardiac ectopic fat by IRM in 3T”, in, MASSON EDITEUR, ACTI, p. A13-A13, viewed no date, <://000302819400053>.
    Note Note
    The following values have no corresponding Zotero field:<br />Author Address: Unite Inserm U626, Marseille, France UMR CNRS 6612, CRMBM, Marseille, France Univ Aix Marseille 2, Marseille, France Serv Cardiol Timone, Marseille, France CHU Nord, Serv Chirurg Digest, Marseille, France INSERM U872, Paris, France Serv Endocrinol Malad Metab &amp; Nutr, Marseille, France<br />Original Publication: Diabetes &amp; Metabolism<br />C2 - Heart<br />
    Note Note
    <p>Sp. Iss. 2<br/>926GN<br/>Times Cited:0<br/>Cited References Count:0</p>
Journal Article
  • Gaborit, B, Jacquier, A, Kober, F, Abdesselam, I, Cuisset, T, Boullu-Ciocca, S, Emungania, O, Alessi, MC, Clement, K, Bernard, M & Dutour, A 2012, “Bariatric surgery induces an improvement of left ventricular function and differential effects on cardiac ectopic fat deposition”, Fundamental & Clinical Pharmacology, vol. 26, p. 3-4.

  • Gaborit, B, Jacquier, A, Kober, F, Abdesselam, I, Cuisset, T, Boullu-Ciocca, S, Emungania, O, Alessi, M-C, Clément, K, Bernard, M & Dutour, A 2012, “Effects of bariatric surgery on cardiac ectopic fat: lesser decrease in epicardial fat compared to visceral fat loss and no change in myocardial triglyceride content”, Journal of the American College of Cardiology, vol. 60, no. 15, p. 1381-1389.
    Résumé : OBJECTIVES: This study investigated the effect of bariatric surgery (BS)-induced weight loss on cardiac ectopic fat using 3T magnetic resonance imaging in morbid obesity. BACKGROUND: Heart disease is one of the leading causes of mortality and morbidity in obese patients. Deposition of cardiac ectopic fat has been related to increased heart risk. Whether sustained weight loss can modulate epicardial fat or myocardial fat is unknown. METHODS: Twenty-three morbidly obese patients underwent 1H-magnetic resonance spectroscopy to determine myocardial triglyceride content (MTGC), magnetic resonance imaging to assess epicardial fat volume (EFV), cardiac function, and computed tomography visceral abdominal fat (VAF) measurements at baseline and 6 months after BS. RESULTS: The BS reduced body mass index significantly, from 43.1±4.5 kg/m2 to 32.3±4.0 kg/m2, subcutaneous fat from 649±162 cm2 to 442±127 cm2, VAF from 190±83 cm2 to 107±44 cm2, and EFV from 137±37 ml to 98±25 ml (all p<0.0001). There was no significant change in MTGC: 1.03±0.2% versus 1.1±0.2% (p=0.85). A significant reduction in left ventricular mass (118±24 g vs. 101±18 g) and cardiac output (7.1±1.6 l/min vs. 5.4±1.0 l/min) was observed and was statistically associated with weight loss (p<0.05). The loss in EFV was limited (-27±11%) compared to VAF diminution (-40±19%). The EFV variation was not correlated with percentage of body mass index or VAF loss (p=0.007). The ratio of %EFV to %VAF loss decreased with sleep apnea syndrome (1.34±0.3 vs. 0.52±0.08, p<0.05). CONCLUSIONS: Six-month BS modulates differently cardiac ectopic fat deposition, with a significant decrease in epicardial fat and no change in myocardial fat. Epicardial fat volume loss was limited in patients with sleep apnea. (Impact of Bariatric Surgery on Epicardial Adipose Tissue and on Myocardial Function; NCT01284816).
    Mots-clés : Adult, Bariatric Surgery, Body Mass Index, crmbm, Female, Follow-Up Studies, Heart Diseases, Humans, Intra-Abdominal Fat, Lipid Metabolism, Magnetic Resonance Imaging, Cine, Magnetic Resonance Spectroscopy, Male, Myocardium, Obesity, Morbid, Pericardium, Retrospective Studies, Risk Factors, Tomography, X-Ray Computed, Triglycerides.
    Note Note
    <p>Gaborit, Benedicte<br />Jacquier, Alexis<br />Kober, Frank<br />Abdesselam, Ines<br />Cuisset, Thomas<br />Boullu-Ciocca, Sandrine<br />Emungania, Olivier<br />Alessi, Marie-Christine<br />Clement, Karine<br />Bernard, Monique<br />Dutour, Anne<br />Journal article<br />Journal of the American College of Cardiology<br />J Am Coll Cardiol. 2012 Oct 9;60(15):1381-1389. doi: 10.1016/j.jacc.2012.06.016. Epub 2012 Aug 29.</p>
    Note Note
    The following values have no corresponding Zotero field:<br/>Author Address: Department of Endocrinology, Metabolic Diseases and Nutrition, Centre Hospitalier Universitaire Nord, Marseille, France; Institut National de la Sante et de la Recherche Medicale, Unite Mixte de Recherche 1062 and Institut National de la Recherche Agronomique, Unite Mixte de Recherche 1260, Marseille, France; Centre de Resonance Magnetique Biologique et Medicale, Unite Mixte de Recherche Centre National de la Recherche Scientifique 6612, Marseille, France; Centre d'investigation Clinique, Hopital Nord, Marseille, France. Electronic address:<br/>Label: A<br/>DOI: ACL<br/>C2 - Heart<br/>ET - 2012/09/04<br/>
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